Food Science and Human Wellness最新文献

{"title":"Heat-treating FM with Clamshell Powder Ameliorate Postmenopausal Osteoporosis by Regulating Bone-Fat Metabolism.","authors":"Hui Yu, Shengliang Yuan, Yuxiang Feng, Yudan Mei, Hengjun Du, Samad Tavakoli, Jiayi Shen, Menghua Wu, Kefeng Wu, Hang Xiao, Hui Luo","doi":"10.26599/fshw.2026.9251234","DOIUrl":"https://doi.org/10.26599/fshw.2026.9251234","url":null,"abstract":"Abstract Postmenopausal osteoporosis is characterized by a disruptive bone‑fat imbalance, yet effective therapies remain limited. Here, for the first time, we link the traditional use of fish maw heat‑treated with clam shell powder (CPFM) to the restoration of bone‑fat balance. Using INFOGEST simulated digestion followed by LC‑MS/MS analysis, we found that CPFM peptides were predominantly low‑molecular‑weight species (84.6% below 1 kDa), with heptapeptides as the most abundant fraction (20%). In ovariectomized mice, CPFM peptides reduced bone marrow fat accumulation and improved bone microstructure (increased BV/TV and BMD). In bone marrow stromal cells (BMSCs), they concurrently inhibited adipogenic differentiation (reduced Oil Red O‑positive area) and promoted osteogenesis (enhanced ALP activity and mineralization). From CPFM digests, we systematically screened and identified an absorbable tetrapeptide, FLLL, based on its high relative abundance (37.8%), predicted bioactivity (PeptideRanker >0.5), cell‑penetrating ability (CPPpred >0.33), and favorable ADMET properties. In cultured BMSCs, FLLL recapitulated the dual effects of CPFM, promoting osteogenesis while suppressing adipogenesis. Mechanistically, both CPFM and FLLL downregulated adipogenic factors (PPARγ, FABP4, FASN) and upregulated osteogenic markers (RUNX2, COL1α2, BGLAP). Surface plasmon resonance confirmed direct binding of FLLL to RUNX2 (KD = 32.5 μM), and rescue experiments indicated that FLLL regulates the bone‑fat balance in association with the PPARγ/RUNX2 axis. Collectively, this study establishes a chain of evidence spanning peptide profiling, in vivo efficacy, active component identification, and mechanistic insight. These findings support CPFM as a promising dietary candidate and identify FLLL with well-defined in vitro bioactivity.","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/local/article_pdf/10.26599/FSHW.2026.9251234.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148861302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep enhancement mechanism of GABA-Producing lactic acid bacteria XBMU-SN-23 fermentation broth in a p-chlorophenylalanine-induced insomnia mouse model","authors":"Dandan Gao, Chenchen Wang, Yushuang Fan, Jiwen Wang, Xuankang Yang, Jinpu Ma, Shangyun Kang, Jinyong Ma, Ping Li","doi":"10.26599/fshw.2026.9251168","DOIUrl":"https://doi.org/10.26599/fshw.2026.9251168","url":null,"abstract":"Abstract γ-Aminobutyric acid (GABA) is an important neurotransmitter found abundantly in animals, plants, and microorganisms. Lactobacilli recognized as natural GABA producers, have garnered significant attention due to their safety and functionality. In our study, we aimed to isolate a high GABA-producing Lactobacillus strain from traditional fermented foods and investigate its growth characteristics, acid-producing capacity, and stress tolerance. Subsequently, a p-chlorophenylalanine (PCPA)-induced insomnia mouse model was established to evaluate the sleep-enhancing effects and underlying mechanisms of the strain's fermentation broth. We isolated six strains of GABA-producing lactic acid bacteria, among which strain XBMU-SN-23 exhibited the highest GABA production (2.150 g/L) as determined by high-performance liquid chromatography (HPLC) and was identified as Lactiplantibacillus plantarum via 16S rDNA sequencing. Treatment with XBMU-SN-23 fermentation broth significantly improved the quiet state of PCPA-induced insomniac mice. It mitigated PCPA-induced damage to hypothalamic neuronal cells, increased the levels of GABA, serotonin (5-HT), interleukin-1 (IL-1), and melatonin (MT), while simultaneously reducing glutamate (Glu) and dopamine (DA) in the serum and hypothalamus of the mice, thereby contributing to the restoration of neurotransmitter balance. Additionally, the treatment led to an increase in the expression of 5-HT1A, GABAARα1, and GABAARγ2 receptor proteins, which play a crucial role in the regulation of molecular pathways and collectively enhance sleep quality. These findings support the sedative-hypnotic benefits of XBMU-SN-23 fermentation broth and provide a theoretical foundation for the future development of functional GABA-producing probiotic products.","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/local/article_pdf/10.26599/FSHW.2026.9251168.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148672229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baohuoside I from Epimedii Folium Exhibits Anti-Triple-Negative Breast Cancer Effects by arresting Cell Cycle Progression","authors":"Qi Tao, Lingli Zhang, Fei Wang, Lei Yu, Di Lei, Chong Yuan, Liuling Pei, Yifei Liu","doi":"10.26599/fshw.2026.9251152","DOIUrl":"https://doi.org/10.26599/fshw.2026.9251152","url":null,"abstract":"Abstract Epimedii Folium has long been used in China as a water-decocted or alcohol-macerated preparation to nourish bodily functions. In 2002, it was officially approved by China’s Ministry of Health as a medicinal herb permitted for use in health food products. Baohuoside I (BHS), a characteristic component of Epimedii Folium, exhibits a broad spectrum of anti-cancer activities. This study aims to explore the therapeutic effects and underlying mechanistic basis of BHS against triple-negative breast cancer (TNBC) using integrated pharmacological and bioinformatics approaches. In vitro experiments demonstrated that BHS dose-dependently inhibited TNBC cell viability (IC50: MDA-MB-468 = 20.02 ± 3.46 µM; MDA-MB-231 = 41.76 ± 1.77 µM), with also significant suppressing cell proliferation and migration (P < 0.05). In vivo, BHS exhibited a favorable safety profile in both healthy and TNBC xenograft model mice (P > 0.05), and also effectively suppressed TNBC xenograft growth (P < 0.05). Transcriptomic analysis combined with machine learning-based bioinformatic analysis identified ten core cell cycle regulatory genes (MCM2, MCM3, MCM5, EXO1, PARP1, CDC45, POLE2, RFC3, PCNA, and CCNE2), whose expression was substantially downregulated by BHS, as validated through molecular biological assays. Cellular thermal shift assay and drug affinity responsive target stability assay identified PMS2 as a putative direct binding target of BHS, with molecular docking validating a high-affinity interaction (binding energy: -8 kcal/mol). Collectively, these results support BHS as a promising safe and effective therapeutic candidate for TNBC, with its anti-tumor activity predominantly associated with the regulation of cell cycle progression.","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/local/article_pdf/10.26599/FSHW.2026.9251152.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148672230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fucoidan from <em>Saccharina japonica</em> attenuates hyperuricemia in mice via modulation of gut microbiota and uric acid metabolism","authors":"Wenya Meng, 张静 Jing ZHANG, Yiming Chen, Xue Zhao, Long Yu, Ping Dong","doi":"10.26599/fshw.2026.9250990","DOIUrl":"https://doi.org/10.26599/fshw.2026.9250990","url":null,"abstract":"Abstract Hyperuricemia (HUA) is a metabolic disease caused by the disorder of uric acid (UA) metabolism. In recent years, it has been found that fucoidan (FC) has anti-HUA effect, but the mechanism is still lack of systematic research. The aim of this study was to investigate the mechanism of FC on HUA through UA metabolism and intestinal homeostasis. Based on PMP-derived ultra performance liquid chromatography analysis, FC was identified as a sulfated polysaccharide composed of galactose, mannose, trace amounts of mannuronic acid, and xylose. The HUA mouse model was induced by a high-purine diet and potassium oxonate. We found that FC significantly ameliorated renal inflammation and injury and reduce serum UA level in HUA mice. Furthermore, FC intervention modulated UA metabolism by regulating purine metabolic enzyme activity and the expression of UA transporters in the kidney and intestine. It also protected the intestinal tract from damage by upregulating the expression of gut barrier-associated genes, including ZO-1, Claudin, Occludin, and MUC2. 16S rRNA sequencing and targeted metabolomics analysis further revealed that FC administration altered the composition of the gut microbiota, increasing the abundance of beneficial bacteria such as Muribaculum, Alloprevotella, Clostridia_UCG-014, and Rikenella, while decreasing the abundance of harmful bacteria such as Parabacteroides, Enterorhabdus, and Muribaculaceae. Meanwhile, FC reversed the reduction in short-chain fatty acid levels caused by HUA. In sum, FC is a natural UA-lowering active substance with multiple targets and pathways. This study provides new evidence supporting the potential of FC as a dietary supplement for patients with HUA.","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/local/article_pdf/10.26599/FSHW.2026.9250990.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148401715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<em>Lactobacillus plantarum</em> Lp2 alleviates the splenic and intestinal injury in cyclophosphamide-induced mice","authors":"Sitong Liu, Yuxuan Ma, Wei-Ke Ji, Feng Yin, Guangquan Ren, Xiujuan Wang, Xia Li, Y Wang, Bo Nan, Y Wang","doi":"10.26599/fshw.2026.9251082","DOIUrl":"https://doi.org/10.26599/fshw.2026.9251082","url":null,"abstract":"Abstract As a frontline chemotherapeutic agent, cyclophosphamide (CTX) frequently induces severe treatment-related adverse effects. Probiotics have emerged as promising dietary adjuvants to alleviate chemotherapy-induced toxicity. This study aimed to explore the alleviate mechanism of Lactobacillus plantarum Lp2 isolated from a traditional fermented food on CTX-induced splenic and intestinal injuries. In CTX-induced mice, oral Lp2 concurrently activated the TLR2/NF-κB/NLRP3 and Nrf2/HO-1 signaling pathways in the spleen, thereby enhancing the levels of cytokines (IL-2, IL-6, IL-1β, TNF-α, and IFN-γ) and the activity of antioxidant enzymes (CAT, SOD, and GSH), protecting splenic architecture and function. Intestinal NLRP3 inflammasome activation by Lp2 modulated similar cytokine profiles (IL-2, IL-6, IL-1β, TNF-α, IFN-γ), demonstrating its gut- immunoregulatory capacity in CTX-induced mice. Furthermore, Lp2 enhanced short-chain fatty acid (SCFA) metabolism and intestinal barrier by modulating the gut microbiota composition through specific bacterial populations, including Clostridium, Duncaniella, Alistipes, Muribaculum, among others, thereby sustaining intestinal physiological homeostasis. These findings established Lp2 as a multifunctional probiotic capable of mitigating CTX chemotherapy-associated side effects, providing a theoretical basis for the development of probiotic dietary supplements.","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/local/article_pdf/10.26599/FSHW.2026.9251082.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148394223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rational Design and Development of a Label-free Fluorescent Biosensor for the Simultaneous and Rapid Detection of Five Fluoroquinolones in Food","authors":"Pingkang Xu, Guosheng Wang, Chi Xu, Yaning Song, Jie Tang, Xianggui Chen, Yukun Huang, Dejian Huang","doi":"10.26599/fshw.2026.9251055","DOIUrl":"https://doi.org/10.26599/fshw.2026.9251055","url":null,"abstract":"Fluoroquinolones (FQs) are veterinary drug residues in the food chain that threaten global food safety and human health and there is a great need for a rapid, sensitive and reliable monitoring method to better safeguard our food systems. In this study, we developed a high-performance aptamer via a recognition-mechanism-oriented truncation strategy, enabling rapid and sensitive detection of multiple FQs. The recognition mechanism between the aptamer and FQs were studied by the combination of computer-aided molecular simulation and experimental verifications. It was revealed that hydrophobicity of FQs critically governs aptamer-target interactions. Guided by these insights, the original sequence was truncated to a 40-nt aptamer, named as W-G1, which preserved key binding sites and structural stability. W-G1 with the characteristic G-quadruplex (G4) conformation demonstrated excellent affinity and stability for FQs. Exploiting the function of this conformation, a label-free fluorescent G4/thioflavine T biosensor was fabricated to detect FQs in chicken ham sausage within 30 minutes. The results showed that detection limits ranged from 1.32 ng/kg to 17.30 ng/kg that are lower than food safety regulation defined limits of 1.0 μg/kg (the lowest LOD of standard method for lomefloxacin), with recoveries of 81.17~115.94%. This mechanism-driven strategy enhances aptamer-based detection of FQs, offering improved performance, design flexibility, and reduced cost.","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/local/article_pdf/10.26599/FSHW.2026.9251055.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147967102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural characterization and protective effects of an <em>Apostichopus japonicus</em> -derived fucoidan against lipopolysaccharide-induced acute lung inflammation","authors":"Yang Hu, Chaonan Ma, Qin-Bing Xue, Xue Wang, Shi-Lin Song, Nuo Shen, Fengyu Liu, Shoudong Guo","doi":"10.26599/fshw.2026.9251033","DOIUrl":"https://doi.org/10.26599/fshw.2026.9251033","url":null,"abstract":"Acute lung inflammation (ALI) poses a significant global health challenge. Conventional synthetic anti-inflammatory drugs often show limited efficacy against ALI and may cause side effects. Natural fucoidans exhibit promising anti-inflammatory properties, but their specific effects and mechanisms in ALI remain unclear. In this study, we characterized the structural features of&nbsp;<em>Apostichopus japonicus</em>-derived fucoidan&nbsp;<strong>AJ2-I</strong>&nbsp;using methylation analysis, 1D/2D nuclear magnetic resonance, and chemical assays. We then evaluated its anti-ALI effects in lipopolysaccharide-challenged C57BL/6J mice and human A549 cells. Structural analysis revealed that&nbsp;<strong>AJ2-I</strong>&nbsp;primarily consists of [→3)-Fucp-(1→] residues with C4 branching, while sulfate groups were predominantly substituted at C2 and C4 positions. Notably, this fucoidan contains unique glycosyls—→4)-β-D-GalpA-6-O-Et-(1→ and →4)-β-D-GalpA-6-OMe-(1→—distinguishing it from previously reported&nbsp;<em>A. japonicus</em>&nbsp;polysaccharides. Functionally,&nbsp;<strong>AJ2-I</strong><strong>&nbsp;</strong>significantly suppressed pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) in both&nbsp;<em>in vivo</em>&nbsp;and&nbsp;<em>in vitro</em>&nbsp;models. Mechanistically, it inhibited <strong>Toll-like receptor 2/4</strong> to suppress<strong>&nbsp;mitogen-activated protein kinase</strong> and<strong>&nbsp;phosphoinositide-3 kinase/protein kinase B&nbsp;</strong>signaling pathways, thereby blocking the activation of key transcription factors, including&nbsp;<strong>nuclear factor kappa-B</strong><strong>&nbsp;</strong>and<strong>&nbsp;c-Jun/activator protein-1</strong>. These findings elucidate the protective role of&nbsp;<em>A. japonicus</em>-derived fucoidan <strong>AJ2-I</strong> in ALI and uncover its underlying molecular mechanisms, supporting the potential use of fucoidans in treating lung inflammation.","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/local/article_pdf/10.26599/FSHW.2026.9251033.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147879632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects of <em>Coreopsis tinctoria</em> flower extract on high-fat and high-fructose diet-induced cognitive deficit: Insight into gut microbiota-derived tryptophan metabolism","authors":"Le Sun, Jingxian Huang, Wenjie Wang, Ming Chao, Yaya Chen, Pei Ma, Lijia Xu, Pei‐Gen Xiao","doi":"10.26599/fshw.2026.9251066","DOIUrl":"https://doi.org/10.26599/fshw.2026.9251066","url":null,"abstract":"The long-term high-fat and high-fructose diet (HFFD) exacerbates cognitive decline and gut microbiota disorder. <em>Coreopsis tinctoria </em>flower (CTF), grown at high altitudes, has been revered as a popular health-enhancing tea modulating glycolipid metabolism in Chinese. However, the neuroprotective effects of CTF against HFFD-induced cognitive decline remain to be elucidated. The present study investigated the hypothesis that the neuroprotective benefits of CTF are mediated by tryptophan metabolism derived from gut microbiota. The phytochemical characterization of CTF was performed by LC-MS/MS-assisted feature-based molecular networking method. Behavioral, neurophysiological and metabolic evaluations demonstrated CTF improved glycolipid metabolic disorders and cognitive decline in HFFD-fed mice. Integrative 16S rRNA sequencing and metabolomics analysis revealed CTF modulated the abundance of specific gut microbial genera (e.g., <em>Colidextribacter</em>) and enhanced gut bacteria-dependent tryptophan metabolites (especially indole-3-lactic acid and indole-3-carboxylic acid) levels in the hippocampus. Notably, antibiotic-induced depletion of microbiota abolished these metabolite changes and the neuroprotective effects of CTF, confirming the crucial role of the intestinal microbiota. Additionally, the protective effects of ICA and ILA on D-glucose induced synaptic damage in SH-SY5Y cells have been identified directly. These findings highlight the importance of microbiota-regulated tryptophan metabolism as a key mechanism behind the cognitive benefits of CTF, demonstrating its potential for managing metabolic disorder–related neurodegenerative conditions.","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/local/article_pdf/10.26599/FSHW.2026.9251066.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147878494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fructooligosaccharide modulates the intestinal exosomal miRNAs to reshape the gut microbiota","authors":"Lu Wang, Chennan Wang, Yuhang Hao, Lili Hu, Runguang Zhang, Xingbin Yang, Yueyue Liu, Ting Li","doi":"10.26599/fshw.2026.9251027","DOIUrl":"https://doi.org/10.26599/fshw.2026.9251027","url":null,"abstract":"Fructooligosaccharide (FOS), a well-recognized prebiotic, is generally considered non-absorbable in the upper gastrointestinal tract, allowing it to reach the colon and exert its prebiotic effects. In this study, we uncovered a novel function of FOS: it directly modulates the expression profile of miRNAs in exosomes derived from intestinal epithelial cells (IECs) and in the feces of antibiotic-induced pseudo-germ-free (PGF) mice, indicating that FOS-mediated regulation of intestinal exosomal miRNAs is independent of its prebiotic role. Furthermore, these miRNAs modified by FOS in turn reconstruct the gut microbial structure, notably elevating the relative abundance of <em>Eubacterium</em>, a component of the core human gut microbiome that is beneficial to gut health. Specifically, supplementation with FOS at 0.6 and 1.2 g/kg/d significantly reduced fecal miR-690 expression in PGF mice by 4.3-fold (from 768.3 ± 92.0 to 177.0 ± 87.5) and 7.8-fold (to 98.7 ± 12.4), respectively (<em>P &lt; </em>0.05). Subsequent<em> in vitro</em> co-culture experiments demonstrated that synthetic miR-690 mimics (2.5 nM) selectively inhibited the growth of <em>Eubacterium limosum</em>. Our findings provide new insights into a novel molecular mechanism by which FOS reshapes the gut microbiome through the regulation of exosomal miRNA expression in IECs.","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/local/article_pdf/10.26599/FSHW.2026.9251027.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147880285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential mechanism of casein phosphopeptide-quercetin covalent/non-covalent complex on gastrointestinal response behavior","authors":"Danjun Guo, Ouyan Han, Mingfei Song, Yan Yang, Zhongjiang Wang, Hongxun Wang, Yi Yang, Wei Xu","doi":"10.26599/fshw.2026.9251067","DOIUrl":"https://doi.org/10.26599/fshw.2026.9251067","url":null,"abstract":"","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147967046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}