Food Science and Human Wellness最新文献

{"title":"Procyanidin B2 improves insulin resistance by regulating the IRS1/PI3K/AKT-Nrf2-GSK3&amp;beta; based on computational biology, molecular evidence and direct binding proof","authors":"Wenli Yang, Shiyun Chen, Rong Tong, Yuhang Yi, Dongsheng Wang, Fangfang Yan, Tao Li, Chenghao Lv, Si Qin","doi":"10.26599/fshw.2026.9250965","DOIUrl":"https://doi.org/10.26599/fshw.2026.9250965","url":null,"abstract":"Procyanidin B2 (PB2), a dimer of oligomeric procyanidins, has been reported to ameliorate abnormal glucose metabolism; however, its efficacy in regulating redox-related insulin resistance (IR) and underlying mechanism has not yet been studied. Currently, antioxidant activity and digestive enzyme inhibitory tests were applied to screen the preliminary chemopreventive effect of PB2 on glucose metabolism dysfunction, further computational biology and molecular verification to elucidate its mechanism on improving IR. The results indicated that PB2 had limited antioxidant property against ROS and inhibitory property on digestive enzyme. Network pharmacology analysis implied that PI3K/AKT and FoxO pathways were the main targeted by PB2 to combating IR. Further molecular data demonstrated that PB2 promoted glycogen synthesis by activation of PI3K/AKT-Nrf2 signaling pathway via promoting posttranscriptional protein stability, nuclear translocation of Nrf2 and ARE binding ability, and inhibited gluconeogenesis by stimulating FoxO1 phosphorylation to reduce the expression of downstream G6Pase. Innovatively, molecular docking coupled with different Pull-Down assays revealed that PB2 could directly bind with AKT, Nrf2 and GSK3β, suggesting PB2 may improve IR via regulation of PI3K/AKT-Nrf2-GSK3β signaling, more than FoxO1 signaling pathway; subsequently, Nrf2 could directly bind with GSK3β, reinforcing evidence for PB2-Nrf2-GSK3β complex formation. Besides, co-treatment with PI3K/AKT and Nrf2 inhibitors or siRNAs highlighted the essential role of Nrf2 activation in PB2-contributed IR improvement. Moreover, PB2 has also been validated to exert its effect via regulation of PI3K/AKT-Nrf2-GSK3β signaling pathway <em>in vivo</em>. Therefore, these findings suggest that PB2 is a potent and promising compound to ameliorate glucose metabolism by targeting IR.","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147381471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Honey as a natural absorption enhancer: Mechanisms underlying the improved oral bioavailability and bioactivity of\u0000 <em>Astragalus</em>\u0000 flavonoids","authors":"Weiye Zhang, Xiao Su, Guangmin Liu, Yanjun Yang, Zhubin Zhang, Xiaobin Jia, Liang Feng, Bing Yang","doi":"10.26599/fshw.2026.9250943","DOIUrl":"https://doi.org/10.26599/fshw.2026.9250943","url":null,"abstract":"","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147381511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tea polyphenol-fortified parboiled rice as a functional food for obesity prevention via gut microbiota regulation","authors":"Kai Du, Qiqi Xie, Zhaoxie He, Xuefei Yang, Zhi Zheng, Xianfeng Du","doi":"10.26599/fshw.2025.9250904","DOIUrl":"https://doi.org/10.26599/fshw.2025.9250904","url":null,"abstract":"<p class=\"0000\" style=\"margin-top: 6.0pt;\"><span lang=\"EN-US\">Digestive properties of starch can be significantly modified by its interaction with polyphenols. This study focused on the modulatory effect of tea polyphenol-fortified parboiled rice (TP) on high-fat diet (HFD)-induced obesity in mice through the regulation of gut microbiota. TP was prepared with parboiled rice (PR) by soaking with tea polyphenols (TPs). The results showed that average body weight of mice fed with an HFD containing parboiled rice (PR-H) or tea polyphenol-fortified parboiled rice (TP-H) decreased by 24.5% and 48.7% compared with the group of an HFD containing white rice (WR-H), respectively. The levels of total triglyceride and total cholesterol were ranked as WR-H &gt; PR-H &gt; TP-H. Histological sections of the liver and epididymal adipose tissue showed that TP reduced lipid accumulation in mice fed with an HFD. Additionally, TP enhanced the liver antioxidant capacity and reduced oxidative damage in mice, thereby ameliorating liver oxidative stress caused by the HFD. Besides, TP modified the microbial community of mice by improving the gut microbiota diversity with the abundance of <em>Akkermansiaceae</em>,<em> Muribaculaceae</em>,<em> and Bacteroidaceae</em> increased. These findings suggested that TP can improve the intestinal microecological environment of mice, regulate lipid metabolism levels, and thereby exert a certain anti-obesity effect.</span>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147381854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<em>In silico</em> identification and biological evaluation of CXCR2 inhibitor naringin to suppress breast cancer premetastatic niche formation and metastasis","authors":"Bo Pan, Shengqi Wang, Yifeng Zheng, Neng Wang, Yingqi She, Shang Xu, Shicui Hong, Cheng Peng, Zhiyu Wang","doi":"10.26599/fshw.2025.9250911","DOIUrl":"https://doi.org/10.26599/fshw.2025.9250911","url":null,"abstract":"Distant metastasis greatly threatens the overall survival of breast cancer patients. C-X-C chemokine receptor 2 (CXCR2) expressed on myeloid-derived suppressor cells (MDSCs) has been proven to be an essential modulator for the formation of premetastatic niche (PMN), which facilitates cancer cell seeding and later metastasis. However, current CXCR2 inhibitors are challenged by serious side effects and toxicities, thus, increasing attention has been paid to discovering CXCR2 antagonists from dietary compounds. Herein, <em>in silico </em>CXCR2<em> </em>pharmacophore models were established and subsequently identified 9'''-methyl lithospermate B<strong>,&nbsp;</strong>thiostrepton, rhoifolin and naringin (NAR) as potential CXCR2 antagonists from the L6020 database of traditional Chinese medicine (TCM) compounds. NAR was further validated to possess the admirable target affinity with CXCR2 by BLI analysis, and DARTS detection also validated CXCR2 as the direct binding target of NAR. Further investigation revealed that NAR could suppress the metastasis of MDSC and reverse its immunosuppressive effects on CD8⁺T cells <em>via</em> CXCR2 inhibition. Subsequent investigations utilizing the zebrafish xenotransplantation model revealed that NAR inhibited the mobilization of MDSCs and the generation of PMNs by targeting CXCR2, ultimately resulting in diminished growth and metastasis of breast cancer. Meanwhile, the mouse breast cancer orthotopic model also validated that NAR could suppress breast cancer PMN formation, growth and metastasis by inhibiting CXCR2. This suppression is evidenced by a reduction in the population of MDSCs in the lung, tumor, and blood, as well as a decrease in CXCR2 phosphorylation within splenic MDSCs.&nbsp; Taken together, our study identifies NAR as a natural CXCR2 antagonist, and sheds novel light on utilizing NAR to prevent PMN formation and breast cancer metastasis <em>via</em> inhibiting MDSC recruitment.","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/local/article_pdf/10.26599/FSHW.2025.9250911.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147381698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fucoidan attenuated diabetic kidney disease through liver-kidney crosstalk based on CXCL1","authors":"S. Jiang, Li‐Ping Jiang, Chenyu Lu, Yuanyuan Tan, Lisa X. Xu, Tao Yan, Zhaoyi Zhong, Yangting Zhang, Wenyan Yu, Tonghui Zhang, Xin Gao, Qi Yan, Qiuzhen Wang","doi":"10.26599/fshw.2025.9250856","DOIUrl":"https://doi.org/10.26599/fshw.2025.9250856","url":null,"abstract":"As a major microvascular complication of diabetes, the incidence of diabetic kidney disease (DKD) is increasing progressively, especially in the elderly. Early intervention is essential for the prevention and treatment of DKD. Organ crosstalk has a strong association in the progression of DKD, while C-X-C motif chemokine ligand 1 (CXCL1), a chemokine plays a critical role in the liver-kidney axis. Our previous studies found that fucoidan interventions prevented the progression of long-term high-fat diet-induced DKD, while also improving liver damage. However, the precise mechanisms through which fucoidan influences CXCL1 associated with liver-kidney crosstalk in DKD are not yet fully understood. The purpose of this study was to investigate the possible mechanism of fucoidan on the high-fat diet-induced DKD. Sixty male C57BL/6J mice were randomly divided into control, DKD, metformin (MET), low dose fucoidan (LFC, 50 mg/kg/d), middle dose fucoidan (MFC, 100 mg/kg/d), and high dose fucoidan (HFC, 200 mg/kg/d) groups for 24 weeks. Compared to the DKD group, HFC significantly reduced the urine creatinine ((555.06 ± 87.67) μg/L vs. (429.62 ± 33.29) μg/L; <em>P &lt; </em>0.05) and glomerular hypertrophy ((61.46 ± 4.54) mmol/L vs. 54.86±2.66 mmol/L; <em>P &lt; </em>0.05). Moreover, HFC treatment significantly reduced the CXCL1 level in the liver ((37.51 ± 6.70) pg/ng prot vs. (63.64 ± 7.15) pg/ng prot; <em>P &lt; </em>0.05) and kidney ((38.77 ± 8.55) pg/ng prot vs. (56.76 ± 7.50) pg/ng prot; <em>P &lt; </em>0.05) compared to the DKD group. Fucoidan treatment inhibited macrophage recruitment (<em>P &lt; </em>0.05) and modulated the expression of IL-6 and TNF-α in the kidney of DKD mice. Moreover, the expression of cyclic GMP-AMP synthase, stimulator of interferon genes, and nuclear factor kappa-B in the HFC group was significantly lower compared with the DKD group. Collectively, these findings suggest that fucoidan exerts a protective effect against DKD induced by a high-fat diet through the crosstalk between the liver and kidney, based on CXCL1.","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/article_pdf/10.26599/FSHW.2025.9250856.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147333179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical Proteomics-Based Reactive Metabolites and Protein Adducts: The New Perspective on the Metabolism of Food Furanocoumarins","authors":"Zhendong Wang, Shan Han, Xiaoyan Cai, Meng Li, Jiaming Qian, Qiyao Jiang, Xiqing Bian, Jian‐Lin Wu, Zhuo Yue","doi":"10.26599/fshw.2025.9250900","DOIUrl":"https://doi.org/10.26599/fshw.2025.9250900","url":null,"abstract":"Furanocoumarins are widely found in various foods and exhibit a range of biological activities. However, due to the structural characteristics of their furan ring, they are susceptible to being metabolized by cytochrome P450 enzymes, thereby forming reactive metabolites (RMs), leading to a dual effect: firstly, the inhibition of CYP enzyme activity, which may result in food-drug interactions affecting drug absorption; and secondly, the formation of covalent bonds between RMs and proteins, potentially disrupting protein function and causing toxicity. Consequently, understanding the metabolic metabolism of furanocoumarins in biological systems is essential for ensuring food safety. This study employed chemical proteomics-based RMs and protein adducts analytical approach to investigate mechanisms of psoralen (PRN), a representative simple-structured furanocoumarin. Initially, dose-dependent hepatotoxicity was confirmed in mice treated with excessive PRN exposure. Subsequently, an LC-MS strategy was developed to identify PRN RM-protein adducts both <em>in vitro</em> (liver microsomes) and <em>in vivo</em> (mouse liver). The abundance of PRN RM-protein adducts was positively correlated with the severity of liver injury. Further analysis identified CYP2C6, CYP3A1, CYP2E1, and CYP2A3 as the primary enzymes facilitating the formation of PRN RM-protein adducts. Finally, label-free quantitative proteomics, integrated with network pharmacology, indicated that disruption of glutathione metabolism may be a potential hepatotoxic pathway activated by PRN RM-protein adducts. This study provides new insights into the dual role of furanocoumarin-induced food-drug interactions and hepatotoxicity, establishes a methodological framework for assessing food safety, and offers critical insights for their judicious application.","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/local/article_pdf/10.26599/FSHW.2025.9250900.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147333998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The improvement in stability and coloration effect of gallic acid acylation of anthocyanins and their quantum chemical mechanism","authors":"Lei Yan, Pingping Wang, 福住 一雄, Chun Chen","doi":"10.1016/j.foodw.2025.100034","DOIUrl":"https://doi.org/10.1016/j.foodw.2025.100034","url":null,"abstract":"To address the limitations in functionality and stability of current anthocyanin-based smart packaging indicators, this study developed an innovative enzymatic acylation strategy. Through lipase-catalyzed grafting of gallic acid (acylation degree: 9.16%), acylated anthocyanins with excellent thermal stability (1.5-fold extended half-life), photostability (32% higher retention after 48-hour UV irradiation), and pH sensitivity (pH 4-8) were successfully prepared. By combining characterization techniques including Fourier transform infrared spectroscopy, high-performance liquid chromatography, and ultraviolet-visible spectroscopy with density functional theory calculations, it was discovered that diacylation synergistically enhanced molecular rigidity through π-π conjugation and hydrogen bonding networks (electrostatic potential energy reduced by 1295 kJ/mol). Notably, despite the reduction in phenolic hydroxyl groups, the acylated products retained strong antioxidant activity (verified by DPPH assay) due to residual galloyl moieties. This research not only elucidated the intrinsic mechanisms of structure-property relationships but also provided novel insights for developing high-performance natural smart packaging indicators, offering important guidance for food freshness monitoring and the design of stabilized anthocyanin functional materials.","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"2 1","pages":"100034-100034"},"PeriodicalIF":0.0,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147332535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary supplements of algal polysaccharides promote ellagic acid biotransformation targeted on gut bacteria","authors":"Zhao‐Rong Li, Rui‐Bo Jia, Weipei Li, G.J. Shang, Donghui Luo, Lianzhu Lin, Mouming Zhao","doi":"10.26599/fshw.2025.9250820","DOIUrl":"https://doi.org/10.26599/fshw.2025.9250820","url":null,"abstract":"Ellagic acid (EA) could be converted into urolithins to exert health-promoting effects by intestinal flora, but the biotransformation capacity varied among individuals. Strategies targeted on gut microflora modulation could be a novel method to obtain more urolithins beyond the inter-individual variability. The study aimed at investigating the impacts of four algal polysaccharides (APs) supplements on EA biotransformation. Results showed that simple APs supplements would increase certain urolithin productions, and APs-EA solid dispersions supplement improved urolithins contents from 4.25 μmol to 6.16-6.79 μmol. The enhancement was related to the proliferation of the EA-metabolic-related bacteria like <em>Gordonibacter</em>, <em>Faecalibacterium</em>, <em>Sutterella</em>, <em>Dialister</em>, <em>Enterocloster</em> and etc. and increasing the bioaccessibility of EA to the bacteria. Furthermore, mono-/co-culture fermentation further verified that <em>Gordonibacter urolithinfaciens</em> was greatly proliferated by simple APs and EA solid dispersions supplements. EA/UPP 1-1 showed the best performances in urolithins productions, and the total urolithins contents increased by 3.78 times compared to control EA group. These results showed dietary supplements could improve biotransformation ability by influencing the EA-metabolic-related bacteria and the access to substrates.&nbsp;","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/article_pdf/10.26599/FSHW.2025.9250820.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147333432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ergothioneine Alleviates Motor Dysfunction in Parkinson&amp;rsquo;s Disease Mouse Model by Restoring Neural Oscillations","authors":"Xinyu Zhu, Wentai Zhang, Xinyue Sheng, Yixin Feng, Ningning Lin, Longfei Li, Chi Man KOON, Fan Hu","doi":"10.26599/fshw.2025.9250721","DOIUrl":"https://doi.org/10.26599/fshw.2025.9250721","url":null,"abstract":"Ergothioneine (EGT), an active compound in many edible mushrooms, has considerable potential for therapeutic intervention in neurodegenerative diseases. However, whether EGT can safely alleviate symptoms of Parkinson’s disease (PD) and its neurophysiological mechanisms remain unclear. In this study, 6-hydroxydopamine (6-OHDA) mouse model of PD was chosen to mimic the pathological progression observed in the early stages of PD patients. After four weeks of EGT treatment (8 mg/kg/d), there was a significant improvement in motor impairments of 6-OHDA mice with a reduction in dopaminergic neuronal loss in the substantia nigra pars compacta (SNc). Using <em>in vivo </em>multi-electrophysiological recordings, we found that EGT treatment increased the firing rates of neurons in the primary motor cortex (M1) of 6-OHDA mice. In addition, EGT treatment notably reduced pathological beta oscillations (β, 13-30 Hz) and beta-gamma phase-amplitude coupling (β-γ PAC) in both the M1 and the subthalamic nucleus (STN) of 6-OHDA mice. These physiological recoveries after EGT treatment were accompanied by increased spine density of pyramidal neurons and upregulated expression of glutamate receptors in the M1. Our findings suggest that EGT is a promising natural neuroprotective agent for slowing or preventing PD progression.","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/article_pdf/1978374092723064834.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147333174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An antibody-aptamer sandwich-based isothermal amplification fluorescence biosensor for the detection of <em>Salmonella</em> Typhimurium","authors":"Kai Dong, Zaihui Du, Yongxia Yu, Wentao Xu, Xiaohong Wang","doi":"10.26599/fshw.2025.9250798","DOIUrl":"https://doi.org/10.26599/fshw.2025.9250798","url":null,"abstract":"<em>Salmonella </em>Typhimurium (<em>S. </em>Typhimurium) is an important foodborne pathogen, its harm is mainly reflected in high pathogenicity, clinical manifestations, and drug resistance. The detection technology for this pathogen is gradually shifting from traditional methods to rapid and highly sensitive molecular biological methods. In order to solve the sensitivity and specificity of Salmonella detection, we built a fluorescent biosensor with an antibody-target-aptamer sandwich structure based on immune recognition and aptamer technology for quantitative detection of<em> S. </em>Typhimurium<em>.</em> By integrating the heterogeneous recognition mode composed of antibody and aptamer with isothermal hybridization chain reaction (HCR), this approach enables highly specific detection of <em>Salmonella</em> while significantly enhancing detection sensitivity through signal amplification. In the HCR hairpin structure, site-specific labeling of the fluorophore and quencher enables fluorescence signal generation via fluorescence resonance energy transfer (FRET), thereby achieving efficient optical signal output. The results show that the proposed enzyme-free heterogeneous recognition mode sensor has a detection limit of 9 CFU/mL and a 10-10⁴ CFU/mL detection range under optimized conditions. It also has good detection performance in milk and drinking water, which are common sources of <em>S. </em>Typhimurium contamination.","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/article_pdf/1981188860198637570.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147334218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}