Food Science and Human Wellness最新文献_第2页

Molecular mechanisms of bitterness and astringency in the oral cavity induced by soyasaponin 大豆皂苷诱导口腔苦味和涩味的分子机制

IF 5.6 1区农林科学

Food Science and Human Wellness Pub Date : 2024-11-01 DOI: 10.26599/FSHW.2023.9250027

Lijie Zhu , Yueying Pan , Yingyan Li , Yingjie Zhou , He Liu , Xiuying Liu

{"title":"Molecular mechanisms of bitterness and astringency in the oral cavity induced by soyasaponin","authors":"Lijie Zhu , Yueying Pan , Yingyan Li , Yingjie Zhou , He Liu , Xiuying Liu","doi":"10.26599/FSHW.2023.9250027","DOIUrl":"10.26599/FSHW.2023.9250027","url":null,"abstract":"<div><div>The interaction mechanism between soyasaponin (Ssa) and bitter receptors/mucin, as well as the saliva interface behavior of Ssa, were investigated to explore the presentation mechanism of Ssa bitterness and astringency (BA). Strong bitterness arising from high Ssa concentrations (0.5–1.5 mg/mL) had a masking effect on astringency. At Ssa concentrations of 1.0–1.5 mg/mL, Ssa micelles altered the structure of mucin, exposing its internal tryptophan to a more polar environment. At Ssa concentrations of 0.05–1.50 mg/mL, its reaction with mucin increased the aggregation of particles in artificial saliva, which reduced the frictional lubricating properties of oral saliva. Ssa-mucin interactions affected the salivary interfacial adsorption layer, and their complexes synergistically reduced the interfacial tension. Ssa monomers and soyasapogenols bind to bitter receptors/mucin via hydrogen bonding and hydrophobic interactions. Class A Ssa binds more strongly than class B Ssa, and thus likely presents a higher BA. In conclusion, Ssa interacts with bitter receptors/mucin causing conformational changes and aggregation of salivary mucin, resulting in diminished frictional lubricating properties of oral saliva. This, in turn, affects taste perception and gustatory transmission.</div></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 6","pages":"Pages 3424-3433"},"PeriodicalIF":5.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140466505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary (poly)phenol intake is associated with cardiometabolic health parameters in adolescents 膳食（多）酚摄入量与青少年心脏代谢健康参数有关

IF 5.6 1区农林科学

Food Science and Human Wellness Pub Date : 2024-11-01 DOI: 10.26599/FSHW.2023.9250023

Emily P. Laveriano-Santos , Sara Castro-Barquero , Camila Arancibia-Riveros , Ana María Ruiz-León , Rosa Casas , Ramón Estruch , Patricia Bodega , Mercedes de Miguel , Amaya de Cos-Gandoy , Jesús Martínez-Gómez , Gloria Santos-Beneit , Juan M. Fernández-Alvira , Rodrigo Fernández-Jiménez , Rosa M. Lamuela-Raventós , Anna Tresserra-Rimbau

{"title":"Dietary (poly)phenol intake is associated with cardiometabolic health parameters in adolescents","authors":"Emily P. Laveriano-Santos , Sara Castro-Barquero , Camila Arancibia-Riveros , Ana María Ruiz-León , Rosa Casas , Ramón Estruch , Patricia Bodega , Mercedes de Miguel , Amaya de Cos-Gandoy , Jesús Martínez-Gómez , Gloria Santos-Beneit , Juan M. Fernández-Alvira , Rodrigo Fernández-Jiménez , Rosa M. Lamuela-Raventós , Anna Tresserra-Rimbau","doi":"10.26599/FSHW.2023.9250023","DOIUrl":"10.26599/FSHW.2023.9250023","url":null,"abstract":"<div><div>The protective role of (poly)phenols against metabolic disorders has been extensively studied in adults but not in adolescents. To assess associations of dietary (poly)phenols and their subclasses with cardiometabolic health parameters in adolescents. A cross-sectional study was conducted in 944 individuals aged 11–14 years enrolled in the SI! Program for Secondary Schools trial (NCT03504059). (Poly)phenol intake was assessed using semi-quantitative food frequency questionnaires and the Phenol-Explorer database. The measured cardiometabolic parameters were waist circumference (WC) age-sex <em>Z</em>-score, blood pressure (BP) age-sex <em>Z</em>-score, blood glucose (BG), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-c). Multilevel mixed-effect linear regression models were applied to examine the association between (poly)phenol quintiles and cardiometabolic health parameters. Compared to the lowest quintile, adolescents in the highest quintile of total (poly)phenol intake had lower WC <em>Z</em>-scores, mean arterial pressure <em>Z</em>-scores, and HDL-c after multivariable adjustment. The WC <em>Z</em>-scores and HDL-c were lower in the highest quintile of flavonoid intake compared to the lowest quintile. The highest quintile of phenolic acid intake was associated with a lower WC <em>Z</em>-score and TG levels, and the highest quintile of stilbene intake with lower BG and TG, and with higher HDL-c compared to the lowest quintile. A higher intake of (poly)phenols, especially flavonoids, phenolic acids, and stilbenes, was associated with better cardiometabolic parameters in adolescents.</div></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 6","pages":"Pages 3381-3390"},"PeriodicalIF":5.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140469005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbial metabolic interaction in fermentation ecosystem and cooperation in flavor compounds formation of Chinese cereal vinegar 发酵生态系统中的微生物代谢作用与中国谷物醋风味化合物形成的协同作用

IF 5.6 1区农林科学

Food Science and Human Wellness Pub Date : 2024-11-01 DOI: 10.26599/FSHW.2023.9250031

Yanfang Wu , Jing Liu , Dantong Liu , Menglei Xia , Jia Song , Kai Liang , Chaochun Li , Yu Zheng , Min Wang

{"title":"Microbial metabolic interaction in fermentation ecosystem and cooperation in flavor compounds formation of Chinese cereal vinegar","authors":"Yanfang Wu , Jing Liu , Dantong Liu , Menglei Xia , Jia Song , Kai Liang , Chaochun Li , Yu Zheng , Min Wang","doi":"10.26599/FSHW.2023.9250031","DOIUrl":"10.26599/FSHW.2023.9250031","url":null,"abstract":"<div><div>Shanxi aged vinegar (SAV) is a famous cereal vinegar in China, which is produced through a solid-state fermentation where diverse microbes spontaneously and complex interactions occur. Here, combined with the metatranscriptomics, the microbial co-occurrence network was constructed, indicating that <em>Lactobacillus</em>, <em>Acetobacter</em> and <em>Pediococcus</em> are the most critical genera to maintain the fermentation stability. Based on an extensive collection of 264 relevant literatures, a transport network containing 2271 reactions between microorganisms and compounds was constructed, showing that glucose (84 % of all species), fructose (67 %) and maltose (67 %) are the most frequently utilized substrates while lactic acid (64 %), acetic acid (45 %) are the most frequently occurring metabolites. Specifically, the metabolic influence of species pairs was calculated using a mathematical calculation model and the metabolic influence network was constructed. The topology properties analysis found that <em>Lactobacillus</em> was the key role with robust metabolic control of vinegar fermentation ecosystem and acetic acid and lactic acid were the main metabolites with feedback regulation in microbial metabolism of SAV. Furthermore, systematic coordination of positive and negative impacts was proved to be inevitable to form flavor compounds and maintain a natural microbial ecosystem. This study provides a new perspective for understanding microbial interactions in fermented food.</div></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 6","pages":"Pages 3472-3481"},"PeriodicalIF":5.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140469337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Krill oil ameliorates benign prostatic hyperplasia by regulating G1-phase cell cycle arrest and altering signaling pathways and benign prostatic hyperplasia-associated markers 磷虾油通过调节 G 1 期细胞周期停滞、改变信号通路和良性前列腺增生相关标记物来改善良性前列腺增生症

IF 5.6 1区农林科学

Food Science and Human Wellness Pub Date : 2024-11-01 DOI: 10.26599/FSHW.2023.9250017

Hoon Kim , Jongyeob Kim , Byungdoo Hwang , Sang Yong Park , Ji-Yeon Shin , Eun Byeol Go , Jae Sil Kim , Youngjin Roh , Soon Chul Myung , Seok-Joong Yun , Yung Hyun Choi , Wun-Jae Kim , Sung-Kwon Moon

{"title":"Krill oil ameliorates benign prostatic hyperplasia by regulating G1-phase cell cycle arrest and altering signaling pathways and benign prostatic hyperplasia-associated markers","authors":"Hoon Kim , Jongyeob Kim , Byungdoo Hwang , Sang Yong Park , Ji-Yeon Shin , Eun Byeol Go , Jae Sil Kim , Youngjin Roh , Soon Chul Myung , Seok-Joong Yun , Yung Hyun Choi , Wun-Jae Kim , Sung-Kwon Moon","doi":"10.26599/FSHW.2023.9250017","DOIUrl":"10.26599/FSHW.2023.9250017","url":null,"abstract":"<div><div>Krill oil (KO) exhibits various biological activities, such as anti-inflammatory and antitumor effects. However, the inhibitory effects of benign prostatic hyperplasia (BPH) <em>in vitro</em> and <em>in vivo</em> have not yet been studied. This study investigated the anti-BPH effects of KO extracted by an enzymatic hydrolysis method. KO treatment inhibited the proliferation of WMPY-1 and BPH-1 cells by induction of G<sub>0</sub>/G<sub>1</sub> phase arrest through the modulation of positive and negative regulators in both prostate cell types. KO treatment stimulated phosphorylation of c-Jun N-terminal kinase (JNK) and p38 signaling. In addition, KO changed the expression of BPH-related markers (5<em>α</em>-reductase, androgen receptor, FGF, Bcl-2, and Bax) and the activity of the proliferation-mediated NF-κB binding motif. KO-induced levels of proliferation-mediated molecules of prostate cells were attenuated in the presence of siRNA-specific p-38 (si-p38) and JNK (si-JNK). Furthermore, the administration of KO alleviated prostate size and weight and the cell layer thickness of prostate glands in a testosterone enanthate-induced BPH rat model. KO treatment altered the level of dihydrotestosterone in serum and the expression levels of BPH-related markers in prostate tissues. Finally, KO-mediated inhibition of prostatic growth was validated by histological analysis. These results suggest that KO has an inhibitory effect on BPH in prostate cells <em>in vitro</em> and <em>in vivo</em>. Thus, KO might be a potential prophylactic or therapeutic agent for patients with BPH.</div></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 6","pages":"Pages 3311-3324"},"PeriodicalIF":5.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140469400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Citrus aurantium L. extract alleviate depression by inhibiting gut microbiota-mediated inflammation in mice 枳实提取物通过抑制肠道微生物群介导的小鼠炎症缓解抑郁症

IF 5.6 1区农林科学

Food Science and Human Wellness Pub Date : 2024-11-01 DOI: 10.26599/FSHW.2023.9250025

Tao Li , Guirong Zeng , Lingfeng Zhu , Yanyang Wu , Qun Zhang , Fuhua Fu , Donglin Su , Gaoyang Li , Qili Li , Yang Shan

{"title":"Citrus aurantium L. extract alleviate depression by inhibiting gut microbiota-mediated inflammation in mice","authors":"Tao Li , Guirong Zeng , Lingfeng Zhu , Yanyang Wu , Qun Zhang , Fuhua Fu , Donglin Su , Gaoyang Li , Qili Li , Yang Shan","doi":"10.26599/FSHW.2023.9250025","DOIUrl":"10.26599/FSHW.2023.9250025","url":null,"abstract":"<div><div>Gut microbiota plays a crucial role in the pathophysiology of depression. This study aimed to explore the antidepressant effect of mature whole <em>Citrus aurantium</em> fruit extract (FEMC) in the chronic unpredictable mild stress (CUMS) model. The behavioral tests were applied to assess antidepressant effect and 16S rRNA sequencing was used to analyze the changes of gut microbiota. The results showed that the major components of FEMC were naringin and neohesperidin and significantly increased the sucrose preference index of the mice. FEMC also could reduce the feeding latency in an open field test and the rest time in a novelty suppressed feeding test. In addition, FEMC could increase CUMS-induced reduction in the levels of BDNF, PSD95, and SYN in the hippocampus. Moreover, FEMC intervention slightly decreased the ratio of Firmicutes to Bacteroidota. Meanwhile, FEMC reduced the abundance of the Prevotellaceae_Ga6A1_group, [<em>Ruminococcus</em>]_<em>torques</em>_group, which have been reported to be closely related to inflammation. Bioinformatics analysis revealed that mitogen-activated protein kinase (MAPK) signaling pathway and lipopolysaccharide biosynthesis were involved in the anti-inflammatory effect of FEMC in the CUMS animal model. Finally, the ELISA results showed that FEMC could significantly reduce the expression of pro-inflammatory cytokines IL-6 and TNF-α in the serum of depressive mice. Our results suggest FEMC can ameliorate depressive behavior by inhibiting gut microbiota-mediated inflammation in mice.</div></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 6","pages":"Pages 3403-3414"},"PeriodicalIF":5.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140469503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bakuchiol ameliorates glycolipid homeostasis by reducing inflammation

IF 5.6 1区农林科学

Food Science and Human Wellness Pub Date : 2024-11-01 DOI: 10.26599/FSHW.2023.9250052

Zhenhua Liu , Xiaoqing Xu , Zhenhua Liang , Yixiao Chen , Qiuyi Wang , Wenyi Kang , Yan Zhang , Bin Cong

{"title":"Bakuchiol ameliorates glycolipid homeostasis by reducing inflammation","authors":"Zhenhua Liu , Xiaoqing Xu , Zhenhua Liang , Yixiao Chen , Qiuyi Wang , Wenyi Kang , Yan Zhang , Bin Cong","doi":"10.26599/FSHW.2023.9250052","DOIUrl":"10.26599/FSHW.2023.9250052","url":null,"abstract":"<div><div>Inflammatory stimulation plays a significant role in the development and worsening of insulin-resistant diabetes. Therefore, it is crucial to identify therapeutic agents that can alleviate insulin resistance by targeting inflammation. Here, we present evidence that Bakuchiol (BL), a monoterpene phenolic compound first discovered from <em>Psoralea corylifolia</em> L. as traditional Chinese medicine, can effectively improve insulin resistance in diabetic mice through anti-inflammation. Our findings demonstrate that BL alleviates inflammation by inhibiting the toll-like receptor 4/nuclear factor κB/mitogen-activated protein kinase axis, consequently enhancing insulin receptor signaling through the c-Jun N-terminal kinase/suppressors of cytokine signaling 3/insulin receptor substrate1 pathway and improving glucolipid homeostasis. Furthermore, the insulin recovery achieved with BL (60 mg/kg) was comparable to that of metformin (200 mg/kg). These results provide further support for considering BL as a potential treatment option for insulin-resistant diabetes mellitus.</div></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 6","pages":"Pages 3159-3170"},"PeriodicalIF":5.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silver carp muscle hydrolysate ameliorated atherosclerosis and liver injury in apoE-/- mice: the modulator effects on enterohepatic cholesterol metabolism 鲤鱼肌水解物改善载脂蛋白E -/-小鼠的动脉粥样硬化和肝损伤：对肠肝胆固醇代谢的调节作用

IF 5.6 1区农林科学

Food Science and Human Wellness Pub Date : 2024-11-01 DOI: 10.26599/FSHW.2023.9250018

Kai Wang , Zixin Fu , Yuqing Tan , Hui Hong , Jianping Wu , Yongkang Luo

{"title":"Silver carp muscle hydrolysate ameliorated atherosclerosis and liver injury in apoE-/- mice: the modulator effects on enterohepatic cholesterol metabolism","authors":"Kai Wang , Zixin Fu , Yuqing Tan , Hui Hong , Jianping Wu , Yongkang Luo","doi":"10.26599/FSHW.2023.9250018","DOIUrl":"10.26599/FSHW.2023.9250018","url":null,"abstract":"<div><div>Atherosclerosis (AS) is a major cause of cardiovascular diseases (CVDs) and a strong link with hepatic steatosis. Silver carp muscle hydrolysate (SCH) possess various beneficial activities but its effect on AS and hepatic steatosis is yet unknown. This study aimed to investigate the effects of SCH on AS lesions and hepatic steatosis using apoE<sup>-/-</sup> mice. Results showed that SCH significantly reduced the vascular AS plaques and alleviated hepatic steatosis lesions in apoE<sup>-/-</sup> mice. Consistent with this, the lipid levels both in circulation and liver were lowered by SCH. The mechanism analysis showed SCH down-regulated the expression of genes involved in lipoproteins production while up-regulated the expression of genes related to reverse cholesterol transport (RCT) in liver. Meanwhile, SCH remarkably promoted transintestinal cholesterol excretion (TICE) process in intestine, partly contributing to the reduction of blood lipids. The peptide profile data indicated LYF, HWPW, FPK, and YPR are the main peptides in SCH that play a vital role in alleviating AS lesions and hepatic steatosis. Our findings provided new knowledge for the application of SCH in ameliorating CVDs and liver diseases.</div></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 6","pages":"Pages 3325-3338"},"PeriodicalIF":5.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140463012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-fatigue activity and mechanism of crocetin loaded nanoliposome in acute exercise-treated mice 纳米脂质体载体藏红花素在急性运动小鼠体内的抗疲劳活性及其机制

IF 5.6 1区农林科学

Food Science and Human Wellness Pub Date : 2024-11-01 DOI: 10.26599/FSHW.2023.9250021

Jian Nan , Jinglei Li , Haishan Wu , Haoran Cheng , Hyun Jin Park , Qingsheng Zhao , Liu Yang

{"title":"Anti-fatigue activity and mechanism of crocetin loaded nanoliposome in acute exercise-treated mice","authors":"Jian Nan , Jinglei Li , Haishan Wu , Haoran Cheng , Hyun Jin Park , Qingsheng Zhao , Liu Yang","doi":"10.26599/FSHW.2023.9250021","DOIUrl":"10.26599/FSHW.2023.9250021","url":null,"abstract":"<div><div>Crocetin displays strong antioxidant, anti-inflammatory and anti-depression activity which is promising to relieve symptoms of fatigue. As a carotenoid, crocetin is difficult to dissolve in water and highly unstable against many environmental factors. Nanoliposome is used to encapsulate crocetin to improve its water dispersion. In the present study, the antifatigue activities and potential mechanism of crocetin loaded nanoliposome (CLN) was extensively investigated. The potential antifatigue pathway of CLN was analyzed. Furthermore, impact of CLN on the gut microbiota structure was examined which contributes to its antifatigue functions. CLN significantly increases exhaustive swimming time of fatigue mice, decreases the blood contents of lactic, blood urea nitrogen (BUN) and malondialdehyde (MDA). At the same time, CLN improves the activity of glutathione peroxidase (GSH-Px) and succinate dehydrogenase (SDH) enzyme, attenuates the oxidant stress in mice. CLN activates the Activated adenosine monophosphate-activated kinase (AMPK)/peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) signaling pathway of fatigue mice, increases the mRNA expression of ATP synthase. It also increases mRNA expression of mitochondrial transcription factor A (TFAM) which promotes mitochondrial biogenesis. Additionally, CLN ameliorates the gut microbiota structure by increasing the abundance of genus such as <em>Lactobacillus</em> in fatigue mice. In summary, CLN exerts strong anti-fatigue properties by decreasing the oxidant stress and the contents of harmful metabolites, augmenting the production of ATP, and potentially ameliorating the gut microbiota structure.</div></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 6","pages":"Pages 3361-3370"},"PeriodicalIF":5.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140463092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbial phenolic metabolites are associated with better frontal lobe cognition 微生物酚类代谢物与改善额叶认知能力有关

IF 5.6 1区农林科学

Food Science and Human Wellness Pub Date : 2024-11-01 DOI: 10.26599/FSHW.2023.9250013

Inés Domínguez-López , Isabella Parilli-Moser , Anna Vallverdú-Queralt , Anna Tresserra-Rimbau , Cinta Valls-Pedret , Zenaida Vázquez-Ruiz , Olga Castañer , Ramon Estruch , Emili Ros , Rosa M. Lamuela-Raventós

{"title":"Microbial phenolic metabolites are associated with better frontal lobe cognition","authors":"Inés Domínguez-López , Isabella Parilli-Moser , Anna Vallverdú-Queralt , Anna Tresserra-Rimbau , Cinta Valls-Pedret , Zenaida Vázquez-Ruiz , Olga Castañer , Ramon Estruch , Emili Ros , Rosa M. Lamuela-Raventós","doi":"10.26599/FSHW.2023.9250013","DOIUrl":"10.26599/FSHW.2023.9250013","url":null,"abstract":"<div><div>With increasing life expectancy, neurodegenerative diseases have become one of the leading causes of ill-health in the elderly. Preventive strategies include following healthy diets, such as the Mediterranean diet, which is particularly rich in polyphenols, bioactive compounds with neuroprotective properties. The aim of this study was to assess the association of microbial phenolic metabolites (MPM) with cognition. This cross-sectional analysis was performed with 200 participants of the PREDIMED trial (Barcelona-Clinic recruitment center). A novel method based on liquid chromatography coupled to mass spectrometry was used to identify urinary MPM (protocatechuic acid, enterodiol glucuronide, enterolactone glucuronide, urolithin B glucuronide, and vanillic acid glucuronide), and cognitive function was evaluated with neuropsychological tests. Multivariable-adjusted ordinary least squares regression was used to assess the associations between cognitive function and MPM, and a score was calculated as the weighted sum of MPM. A higher MPM score was associated with better frontal lobe function. Among individual metabolites, vanillic acid glucuronide was correlated with frontal cognitive performance. Participants with higher concentrations of vanillic acid glucuronide and urolithin B glucuronide obtained better scores in the Color Trail Test part 2. A higher score for urinary multi-MPM was associated with better frontal cognitive performance in an older Mediterranean population.</div></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 6","pages":"Pages 3266-3272"},"PeriodicalIF":5.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140464725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effects of Bifidobacterium breve on imiquimod-induced psoriasis in mice through secondary bile acid production and FXR-TLR4/NF-κB pathway 双歧杆菌通过次级胆汁酸生成和 FXR-TLR4/NF-κB 通路对 IMQ 诱导的小鼠银屑病的保护作用

IF 5.6 1区农林科学

Food Science and Human Wellness Pub Date : 2024-11-01 DOI: 10.26599/FSHW.2023.9250029

Xinqi Chen , Yang Chen , Catherine Stanton , R. Paul Ross , Jianxin Zhao , Bo Yang , Wei Chen

{"title":"Protective effects of Bifidobacterium breve on imiquimod-induced psoriasis in mice through secondary bile acid production and FXR-TLR4/NF-κB pathway","authors":"Xinqi Chen , Yang Chen , Catherine Stanton , R. Paul Ross , Jianxin Zhao , Bo Yang , Wei Chen","doi":"10.26599/FSHW.2023.9250029","DOIUrl":"10.26599/FSHW.2023.9250029","url":null,"abstract":"<div><div>This study aimed to evaluate the effects of <em>Bifidobacterium breve</em> CCFM683 on psoriasis and to investigate the underlying mechanisms. <em>B. breve</em> CCFM683 significantly ameliorated psoriasis in mice as well as elevated the deoxycholic acid (DCA) and lithocholic acid (LCA) in the colon compared with those of the imiquimod (IMQ)-treated mice. Meanwhile, <em>B. breve</em> CCFM683 increased the relative abundance of DCA-producing <em>Lachnoclostridium</em> and diminished the harmful <em>Desulfovibrio</em> and Prevotellaceae UCG001. Additionally, the farnesoid X receptor (FXR) in the skin was activated and the expression of the Toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) pathway was inhibited, and the downstream interleukin (IL)-17 and tumor necrosis factor (TNF)-α were downregulated whereas IL-10 was up-regulated. Moreover, the subsequent hyperproliferation of keratinocytes and the dysfunction of the epidermal barrier were improved. In conclusion, CCFM683 administration ameliorated IMQ-induced psoriasis via modulating gut microbiota, promoting the DCA production, regulating the FXR-TLR4/NF-κB pathway, diminishing proinflammatory cytokines, and regulating keratinocytes and epidermal barrier. These findings may be conducive to elucidating the mechanism for probiotics to ameliorate psoriasis and to promote its clinical trials in skin disease.</div></div>","PeriodicalId":12406,"journal":{"name":"Food Science and Human Wellness","volume":"13 6","pages":"Pages 3447-3460"},"PeriodicalIF":5.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140466773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0