Controlled coupling and characterization of oyster (Crassostrea gigas) ferritin with gold nanostars

IF 5.6 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Food Science and Human Wellness Pub Date : 2024-11-01 DOI:10.26599/FSHW.2023.9250007

Han Li , Xiaoyu Xia , Shuzhen Cheng , Jiachen Zang , Zhenyu Wang , Xianbing Xu , Ming Du

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引用次数: 0

Abstract

Ferritin has good thermal stability, resistance to certain acids and bases, and targeting, and has broad application prospects in the synthesis of gold nanostars (AuNS). In this study, we screened monodisperse AuNS with uniform particle size and morphology through a one-step synthesis method and coupled the synthesized AuNS with oyster ferritin (GF1). The results showed that the surface plasmon resonance (SPR) peaks of the coupled GF1@AuNS changed significantly, and the changes in infrared spectra and potential confirmed the success of the synthesis, while the microscopic morphology showed an increase in particle size and surface peak coverage. Furthermore, GF1@AuNS does not induce cell death in the 100 µmol/L range, is highly stable in physiological environments, and exhibits good X-ray attenuation in micro-computed tomography. Due to the unique functional activity of ferritin and AuNS, GF1@AuNS has potential applications in food detection and drug development in the future.

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牡蛎（Crassostrea Gigas）铁蛋白与金纳米柱的可控耦合与表征

铁蛋白具有良好的热稳定性、耐某些酸碱、靶向性，在金纳米恒星（AuNS）的合成中具有广阔的应用前景。在本研究中，我们通过一步合成的方法筛选了粒径和形貌均匀的单分散AuNS，并将合成的AuNS与牡蛎铁蛋白（GF1）偶联。结果表明，偶联GF1@AuNS的表面等离子体共振（SPR）峰发生了明显变化，红外光谱和电位的变化证实了合成的成功，而微观形貌则显示出粒径和表面峰覆盖率的增加。此外，GF1@AuNS在100µmol/L范围内不会诱导细胞死亡，在生理环境中高度稳定，并且在微计算机断层扫描中表现出良好的x射线衰减。由于铁蛋白和AuNS具有独特的功能活性，GF1@AuNS在未来的食品检测和药物开发中具有潜在的应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Food Science and Human Wellness Agricultural and Biological Sciences-Food Science

CiteScore

8.30

自引率

5.70%

发文量

审稿时长

28 days

期刊介绍： Food Science and Human Wellness is an international peer-reviewed journal that provides a forum for the dissemination of the latest scientific results in food science, nutriology, immunology and cross-field research. Articles must present information that is novel, has high impact and interest, and is of high scientific quality. By their effort, it has been developed to promote the public awareness on diet, advocate healthy diet, reduce the harm caused by unreasonable dietary habit, and directs healthy food development for food industrial producers.