Foodborne pathogens and disease最新文献

{"title":"The Effects of Baitouweng Decoction on <i>Salmonella</i> Typhimurium Infection and Its Underlying Mechanisms Evaluated by <i>In Vivo</i> and <i>In Vitro</i> Experiments, Network Pharmacology Analysis, and Molecular Docking Technology.","authors":"Cui Xinhua, Wang Yang, Shi Jinyang, Xu Hongyue, Yu Wanlu, Zhu Mingmei, Qiu Jiazhang, Yu Lu","doi":"10.1089/fpd.2023.0169","DOIUrl":"10.1089/fpd.2023.0169","url":null,"abstract":"<p><p><i>Salmonella</i> Typhimurium is a foodborne pathogen threatening livestock and human health. It is highly resistant to commonly used clinical antibiotics, and it is urgently needed to explore new anti-<i>Salmonella</i> treatment schemes. In this study, first, our <i>in vivo</i> mouse experiments showed that Baitouweng decoction (BTW), a classical Traditional Chinese Medicine (TCM) prescription, had good efficacy against <i>Salmonella</i> Typhimurium infection: mitigating weight loss of mice; lowering the bacterial load of liver, spleen, and colon; reducing the production of serum inflammatory factors (interleukin-1β and tumor necrosis factor-α); and decreasing histological index scores than that in the <i>Salmonella</i> Typhimurium infection group. Furthermore, we explored the potential active components and molecular mechanism of BTW in the treatment of <i>Salmonella</i> Typhimurium infection. A total of 465 compounds of BTW were retrieved from herb website and 227 bioactive compounds were identified, 911 potential BTW-related targets and 1,602 disease targets of <i>Salmonella</i> Typhimurium infection were acquired by ten public analytical databases, among them, 188 genes were overlay targets of BTW-<i>Salmonella</i> Typhimurium; String, Metascape, and Cytoscape plug-in Molecular Complex Detection and ClueGo analysis pointed that BTW exerted an anti-<i>Salmonella</i> effect through a multicomponent, multitarget, and multipathway manner, including 10 hub targets (TNF, AKT CASP3, ALB, EGFR, JUN, MAPK, STAT3, VEGFA, and TP53) and 94 pathways such as cell apoptosis, inflammation, and metabolism. Finally, AutoDock Vina showed that the hub target AKT1 with menispermine and quercetin had good binding energy, which was confirmed by the <i>in vitro</i> cellular thermal shift assay and drug affinity responsive target stability assay. This study laid the foundation for further study of BTW mechanism and for further development of BTW anti-<i>Salmonella</i>.</p>","PeriodicalId":12333,"journal":{"name":"Foodborne pathogens and disease","volume":" ","pages":"140-158"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flagella Phenotypic Variations of ST34 Type <i>Salmonella</i> Typhimurium and Variants.","authors":"Xin Wu, Fanan Suksawat, Patchara Phuektes, Supatcharee Siriwong, Hongmei Liu, Wengui Li, Sunpetch Angkititrakul","doi":"10.1089/fpd.2023.0091","DOIUrl":"10.1089/fpd.2023.0091","url":null,"abstract":"<p><p><i>Salmonella enterica</i> serovar Typhimurium and its variants are the most common serotypes of human salmonellosis cases. Serotyping <i>Salmonella</i> Typhimurium and its variants has always been challenging. Our previous work found that among 14 <i>Salmonella</i> Typhimurium and variant strains, some different antigenic formulas had 100% pulsed-field gel electrophoresis (PFGE) similarity. The 14 strains were sorted into 3 groups; in each group, the different antigenic formulas had the same PFGE patterns. This phenomenon suggested that different antigenic formula identification might originate from a common ancestor subtyped by PFGE. To assess whether the serotyping method on <i>Salmonella</i> Typhimurium and variant strains reflected the genetic relationship, we improved the discrimination for the phylogenetic relationship among the 14 <i>Salmonella</i> Typhimurium and variant strains using Fourier-transform infrared spectroscopy (FTIR) and whole-genome multilocus sequence typing (wgMLST). We compared the wgMLST assay of 14 <i>Salmonella</i> Typhimurium and variant strains from this study with 50 public ST34 strain data of <i>Salmonella</i> Typhimurium and variant strains. We also compared flagella (H antigen)-related genes based on the whole genome of 14 strains and the other 293 ST34 public database for further understanding of this question. The phylogenetic results (PFGE) showed no regularity between the antigenic formulas and genotypes. The results of the higher discrimination power assays (FTIR and whole-genome multilocus sequence typing) also showed no regularity between the antigenic formulas and genotypes (or phenotypes). The 58 flagella encoding genes of different antigenic formulas were sorted into 13 patterns. However, a similar phenomenon was found: the same flagella encoding gene patterns could express different antigenic formulas. In conclusion, there is no consistency between the antigenic formulas and phylogenetic relationships among ST34 <i>Salmonella</i> Typhimurium and variant strains, even in flagella antigenic formula and flagella encoding genes.</p>","PeriodicalId":12333,"journal":{"name":"Foodborne pathogens and disease","volume":" ","pages":"159-166"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140101405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial Resistance Profiles of <i>Campylobacter</i> spp. Recovered from Chicken Farms in Two Districts of Bangladesh.","authors":"Mehedi Hasan, Sudipta Talukder, Amit Kumar Mandal, Syeda Tanjina Tasmim, Sonia Parvin, Yamin Ali, Mahmudul Hasan Sikder, Thomas J Callaghan, Ricardo J Soares Magalhães, Taohidul Islam","doi":"10.1089/fpd.2023.0079","DOIUrl":"10.1089/fpd.2023.0079","url":null,"abstract":"<p><p>The rapid emergence of antimicrobial resistance (AMR) in <i>Campylobacter</i> has reinforced its status as a foodborne pathogen of significant public health concern. Resistant <i>Campylobacter</i> is typically transferred to humans via the consumption of contaminated animal products, particularly poultry. The genes associated with antimicrobial resistance in <i>Campylobacter</i> spp. are poorly understood. To address this knowledge gap, we conducted a prevalence survey of AMR <i>Campylobacter</i> across 84 chicken farms in two districts of Bangladesh. Pooled cloacal swabs were collected from chickens and underwent bacteriological testing for <i>Campylobacter</i> spp. with PCR confirmation. Antimicrobial susceptibility was tested against 14 antibiotics by disk diffusion method, and 12 resistance genes were screened in <i>Campylobacter</i>-positive isolates using multiplex PCR. A total of 34 (40.5%) farms were <i>Campylobacter</i>-positive of which 73.5% of isolates were resistant to at least 10 antibiotics. The antimicrobial susceptibility results indicate a high level of resistance against streptomycin (97.1%), clindamycin (97.1%), ampicillin (94.1%), tetracycline (94.1%), erythromycin (91.2%), ciprofloxacin (88.2%), nalidixic acid (85.3%), and imipenem (82.4%), and comparatively a low frequency of resistance to chloramphenicol (47.1%), ceftazidime (44.1%), and colistin (35.3%). Multidrug-resistant (MDR) and extensively drug-resistant <i>Campylobacter</i> were identified in 97.1%, and 50% of isolates, respectively. Ten resistance genes were identified including <i>bla</i>_TEM (in 97.1% of isolates), <i>strA</i>-<i>strB</i> (85.9%), <i>tetA</i> (70.6%), <i>tetB</i> (32.4%), <i>qnrS</i> (23.5%), <i>bla</i>_CTX-M-1 (20.6%), <i>qnrB</i> (20.6%), <i>bla</i>_SHV (8.8%), <i>aadB</i> (5.9%), and <i>qnrA</i> (2.9%). Our findings demonstrate that resistance to ampicillin, tetracycline, and ceftazidime in <i>Campylobacter</i> isolates was significantly (<i>p</i> ≤ 0.05) associated with the presence of <i>bla</i>_TEM, <i>tetA</i>, and <i>bla</i>_SHV genes, respectively. The high rates of AMR in <i>Campylobacter</i> isolates from our study are not surprising given the liberal use of antimicrobials and incomplete biosecurity provisions on farms. Of particular concern are resistance rates to those classes of antibiotics that should be reserved for human use (azithromycin, ciprofloxacin, and colistin). AMR was more prevalent in chicken farms that used multiple antibiotics, engaged in prophylactic treatment of the birds, and improperly disposed of antibiotic packages. The high prevalence of MDR in chicken-derived <i>Campylobacter</i> isolates from the different regions of our study reinforces the need for more prudent use of antimicrobial compounds in Bangladeshi chicken farms.</p>","PeriodicalId":12333,"journal":{"name":"Foodborne pathogens and disease","volume":" ","pages":"118-130"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140335255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial Resistance Characteristics of Fecal <i>Escherichia coli</i> and <i>Enterococcus</i> Species in U.S. Goats: 2019 National Animal Health Monitoring System Enteric Study.","authors":"Catherine A Gensler, Stephanie C Hempstead, Shivaramu Keelara, Paula J Fedorka-Cray, Natalie J Urie, Alyson M Wiedenheft, Keira Stuart, Katherine L Marshall, Megan E Jacob","doi":"10.1089/fpd.2023.0089","DOIUrl":"10.1089/fpd.2023.0089","url":null,"abstract":"<p><p><i>Escherichia coli</i> and <i>Enterococcus</i> species are normal bacteria of the gastrointestinal tract and serve as indicator organisms for the epidemiology and emergence of antimicrobial resistance in their hosts and the environment. Some <i>E. coli</i> serovars, including <i>E. coli</i> O157:H7, are important human pathogens, although reservoir species such as goats remain asymptomatic. We describe the prevalence and antimicrobial resistance of generic <i>E. coli</i>, <i>E. coli</i> O157:H7, and <i>Enterococcus</i> species collected from a national surveillance study of goat feces as part of the National Animal Health Monitoring System (NAHMS) Goat 2019 study. Fecal samples were collected from 4918 goats on 332 operations across the United States. Expectedly, a high prevalence of <i>E. coli</i> (98.7%, 4850/4915) and <i>Enterococcus</i> species (94.8%, 4662/4918) was found. <i>E. coli</i> O157:H7 prevalence was low (0.2%; 10/4918). <i>E. coli</i> isolates, up to three per operation, were evaluated for antimicrobial susceptibility and 84.7% (571/674) were pansusceptible. Multidrug resistance (MDR; ≥3 classes) was uncommon among <i>E. coli</i>, occurring in 8.2% of isolates (55/674). Resistance toward seven antimicrobial classes was observed in a single isolate. Resistance to tetracycline alone (13.6%, 92/674) or to tetracycline, streptomycin, and sulfisoxazole (7.0% 47/674) was the most common pattern. All <i>E. coli</i> O157:H7 isolates were pansusceptible. <i>Enterococcus</i> isolates, up to four per operation, were prioritized by public health importance, including <i>Enterococcus faecium</i> and <i>Enterococcus faecalis</i> and evaluated. Resistance to lincomycin (93.8%, 1232/1313) was most common, with MDR detected in 29.5% (388/1313) of isolates. The combination of ciprofloxacin, lincomycin, and quinupristin resistance (27.1%, 105/388) was the most common pattern detected. Distribution and characteristics of antimicrobial resistance in <i>E. coli</i> and <i>Enterococcus</i> in the U.S. goat population from this study can inform stewardship considerations and public health efforts surrounding goats and their products.</p>","PeriodicalId":12333,"journal":{"name":"Foodborne pathogens and disease","volume":" ","pages":"97-108"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140174097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prevalence of <i>Brucella</i> spp. in Dairy Products in Iran: A Systematic Review and Meta-Analysis.","authors":"Narges Shahbazpour, Elahesadat Hosseini, Seyed Ehsan Beladian Behbahan, Fatemeh Esfarjani, Seyed Amir Mohamad Mortazavian, Abdol-Samad Abedi, Slim Smaoui","doi":"10.1089/fpd.2024.0093","DOIUrl":"10.1089/fpd.2024.0093","url":null,"abstract":"<p><p>Brucellosis, a significant zoonotic disease, threatens food safety substantially, particularly in developing nations such as the Middle East. This study aimed to comprehensively assess the prevalence of <i>Brucella</i> spp. in Iranian milk and dairy products through a systematic review and meta-analysis. A thorough search of international and domestic databases from January 2008 to October 2023 identified 38 relevant studies encompassing 11,130 samples for meta-analysis. The overall prevalence of <i>Brucella</i> spp. in Iranian dairy products was 22% (95% CI: 16-28%). The highest and lowest overall prevalence of <i>Brucella</i> spp. in milk were found in raw goat milk 27% (95% CI: 11-42%) and raw camel milk 15% (95% CI: -0.42 to 72%), respectively. The overall prevalence of traditional cheese, ice cream, and cream is estimated to be 9% (95% CI: -16 to 35%), 2% (95% CI: -2.78 to 2.82%), and 9% (95% CI: -0.94 to 1.12%). Geographical disparities were evident, with Zanjan province reporting the highest contamination rate, 53%, while Razavi Khorasan province had the lowest, 1%. However, the prevalence of <i>Brucella</i> spp. in Iranian dairy products has fluctuated over time, with a significant association between the study year and sample size. Comprehensive planning, robust policy implementation, and rigorous monitoring are imperative to mitigate and ultimately eliminate <i>Brucella</i> contamination in dairy products effectively. Further research is essential to refine prevalence estimates and develop targeted prevention strategies to safeguard public health.</p>","PeriodicalId":12333,"journal":{"name":"Foodborne pathogens and disease","volume":" ","pages":"71-85"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial Resistance Profiles of <i>Escherichia coli</i> Isolated from Food Animal Carcasses During 2010-2023 in South Korea.","authors":"Yu-Jeong Hwang, Bo-Youn Moon, Ji-In Kim, Md Sekendar Ali, Hyun-Ju Song, Yeon-Hee Lee, Ji-Hyun Choi, Hee-Seung Kang, Hyeon-Jung Park, Jae-Myung Kim, Suk-Kyung Lim","doi":"10.1089/fpd.2024.0168","DOIUrl":"10.1089/fpd.2024.0168","url":null,"abstract":"<p><p>Antimicrobial-resistant bacterial contamination of meat poses a significant global public health risk. We aimed to determine antimicrobial resistance profiles and trends of <i>Escherichia coli</i> recovered from carcasses of healthy food-producing animals in South Korea during 2010-2023. In total, 4748 <i>E. coli</i> isolates obtained from cattle (<i>n</i> = 1582), pigs (<i>n</i> = 1572), and chickens (<i>n</i> = 1594) were assessed for susceptibility to 12 antimicrobials. Antimicrobial resistance was different among samples. Overall, antimicrobial resistance was high in pigs and chicken carcasses. More than about 80% of isolates from pigs and chickens exhibited resistance to one or more antimicrobials. Among the tested antimicrobials, resistance to ampicillin, chloramphenicol, streptomycin, and tetracycline was significantly higher in pigs and chickens compared with cattle (<i>p</i> < 0.05). Moreover, chicken isolates showed much higher resistance to nalidixic acid and ciprofloxacin than other samples. Resistance to critically important antimicrobials, colistin, remained less than about 1%, while resistance to ceftiofur showed increased trends in pig and chicken samples. Higher multidrug-resistant (MDR) isolates were identified in chickens and pigs compared with cattle (<i>p</i> < 0.05). Furthermore, most MDR patterns include streptomycin and tetracycline resistance. MDR <i>E. coli</i> contaminating meat during slaughter can be transmitted to humans via the food chain. Thus, prudent use of antimicrobials and proper hygienic practices are urgently needed to reduce the risk of transmission.</p>","PeriodicalId":12333,"journal":{"name":"Foodborne pathogens and disease","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Characterization of Whole Genome Sequencing of <i>Salmonella</i> spp. in Shapingba District, Chongqing, China, 2016-2023.","authors":"Fei Chen, Xin Zhang, Jie Zheng, Yu Tang, Xiaoxia Fan, Yulan Huang, Haihong Jia, Xiaorong Yang","doi":"10.1089/fpd.2024.0138","DOIUrl":"https://doi.org/10.1089/fpd.2024.0138","url":null,"abstract":"<p><p>In recent years, <i>Salmonella</i> infection is a major global public health concern, particularly in food safety. This study analyzed the genomes of 102 <i>Salmonella</i> strains isolated between 2016 and 2023 from food, foodborne disease patients, and food poisoning incidents, focusing on their molecular characteristics, antibiotic resistance genes (ARGs), and virulence genes. <i>S. enterica</i> serovar Enteritidis (37.3%) and <i>S. enterica</i> serovar Typhimurium (21.6%, including its monophasic variant 1,4,[5],12:i:-) were the main strains among 22 serotypes. Multilocus sequence typing revealed 23 sequence types (STs), with ST11, ST19, and ST34 as the most prevalent. All strains carried at least 24 ARGs. Detection rates for <i>aac(6')-Iy</i>, <i>bla</i>_TEM-1, and <i>sul2</i> ranged from 44.1% to 63.7%, mainly in <i>S.</i> Enteritidis and <i>S.</i> Typhimurium. Rates for <i>qnrS1</i>, <i>sul1</i>, and <i>aadA</i> were 12.8% to 16.7%, while <i>mcr-1</i> appeared in one ST34 <i>S.</i> Typhimurium strain. All strains contained at least 98 virulence genes. The genes <i>pefABCD</i>, <i>mig-5</i>, and <i>spvBCD</i> were in 48.0% of strains, while <i>rck</i> was found in 36.3%, mainly linked to <i>S.</i> Enteritidis and <i>S.</i> Typhimurium. The <i>tssM</i> gene was found in 37.3% of the strains, exclusively in <i>S.</i> Enteritidis. Core genome single nucleotide polymorphisms (cgSNPs) analysis grouped the strains into nine clusters, with 75.5% belonging to three major groups. Food poisoning event 1 was correlated with cluster 3, while events 2 and 3 were linked to cluster 1. Across events, SNP differences among strains were ≤6. Strains with SNP differences ≤10 were also found in other clusters. This method is promising for tracking sporadic cases and identifying potential foodborne safety incidents. <i>Salmonella</i> strains in the region exhibit substantial genetic diversity, demonstrating the efficacy of cgSNPs analysis for source tracking. Ongoing surveillance is essential given the prevalence of ARGs and virulence genes. This study provides a data foundation for local <i>Salmonella</i> epidemiology.</p>","PeriodicalId":12333,"journal":{"name":"Foodborne pathogens and disease","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143003059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food Safety Concerns in Pakistan: Monitoring of Antimicrobial-Resistant Bacteria and Residue Contamination in Commercially Available Fish and Poultry Meat Samples.","authors":"Muhammad Usman Qamar, Kaneez Fizza, Muhammad Ismail Chughtai, Muhammad Shafique, Bibigul Seytkhanova, Ayaz Yktiyarov, Aatika, Zikria Saleem, Sana Mustafa, Zainab Tufail, Mahnoor Chaudhry, Tawaf Ali Shah, Ahmad Mohammad Salamatullah, Mohammed Bourhia","doi":"10.1089/fpd.2024.0117","DOIUrl":"https://doi.org/10.1089/fpd.2024.0117","url":null,"abstract":"<p><p>Food safety is a critical issue in the 21st century due to antibiotic-resistant bacteria causing harmful foodborne diseases. This comprehensive study meticulously examined the presence of bacterial isolates, quinolone residue, and antimicrobial resistance genes in samples of broiler and fish meat. Forty samples were collected from various locations in the Faisalabad metropolis. The samples underwent culture on various types of agar, and the Vitek 2 compact system was used to confirm the isolates along with determining the minimum inhibitory concentration of antibiotics. Additionally, polymerase chain reaction was used to identify antimicrobial-resistant genes, and an enzyme-linked immunosorbent assay (ELISA) kit was employed to detect quinolone residue in each sample. Out of 40 fish samples, 66 polymicrobials were identified with <i>Escherichia coli</i> being the most prevalent (26.6%), followed by <i>Klebsiella pneumoniae</i> (16.6%) and <i>Acinetobacter baumannii</i> (15%). Furthermore, 70 polymicrobial were identified in the broiler samples, with 41.6% <i>E. coli</i> and 15% <i>K. pneumoniae</i>. In fish isolates, 14 (21%) <i>qnr</i> gene, 18 (27.2%) <i>bla</i>_CTX-M, and 11 (16.6%) <i>bla</i>_NDM-1, and in broiler samples, 19 (27.1%) <i>qnr</i> gene, 19 (27.1%) <i>bla</i>_TEM and 22 (31.4%) <i>bla</i>_CTX-M, and 5 (7.1%) <i>bla</i>_NDM-1 were found. Eighteen (45%) broiler and 7 (17.5%) fish samples with more than 100 µg per kg (ppb) for quinolone residues. The study concluded that the increased prevalence of multidrug-resistant bacteria and quinolone residue poses a significant threat to consumer health.</p>","PeriodicalId":12333,"journal":{"name":"Foodborne pathogens and disease","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143003058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experience and Perspectives on Antibacterial Therapy for Listeriosis in a Tertiary Teaching Hospital in China: A Retrospective Study and Health Care Provider Survey.","authors":"Naiju Zhang, Zhenjie Wang, Zhijun Li, Yongzhong Xie, Jinchun Liu, Chunming Gao, Chuanmiao Liu, Tianping Chen","doi":"10.1089/fpd.2024.0079","DOIUrl":"https://doi.org/10.1089/fpd.2024.0079","url":null,"abstract":"<p><p>Listeriosis is a rare, life-threatening bacterial infection. Prompt, appropriate antibiotic treatment is essential to save lives. We aimed to investigate antibiotic selection and listeriosis knowledge among health care providers. We first performed a retrospective study on patients with listeriosis who were treated in a hospital in China from January 2013 to March 2023. Patient characteristics and antibiotic selections were recorded. Antibiotics were classified as effective or ineffective based on the efficacy classifications listed in <i>The Sanford Guide to Antimicrobial Therapy</i> (50^th edition). We then conducted a questionnaire survey of health care providers to investigate their listeriosis knowledge and practices between April 2023 to May 2023. Fifteen listeriosis patients were identified, with a case fatality rate of 26.7% (4/15). Empirical treatments assessed as effective antibiotics or ineffective antibiotics were given to 33.3% (5/15) and 66.7% (10/15) of the patients, respectively. After <i>Listeria monocytogenes</i> was identified, 40% (6/15) of the patients received an adjustment to their antibiotics, although 50% (3/6) patients still received ineffective antibiotics. The questionnaire survey of 77 participating health care providers showed that 32.9% (24/73) of the clinicians were unaware of the appropriate antibiotics for listeriosis. Most participants (83.1%, 64/77) would read the drug sensitivity report before selecting the antibiotics. The selection of effective antibiotics differed between the infectious diseases department and other departments (<i>p</i> < 0.001), but did not differ between junior title and other titles (<i>p</i> = 0.088). Most patients with listeriosis did not receive appropriate antibiotics, which might have accounted for the high fatality rate, and may have resulted from inadequate listeriosis knowledge. More education and correct reporting of drug sensitivity results are urgently needed.</p>","PeriodicalId":12333,"journal":{"name":"Foodborne pathogens and disease","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142947051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Listeriosis Case Associated with Ice Cream Consumption in China in 2019.","authors":"Xiaoyuan Zhang, Yanlin Niu, Yuzhu Liu, Penghang Zhang, Xiaochen Ma","doi":"10.1089/fpd.2024.0009","DOIUrl":"https://doi.org/10.1089/fpd.2024.0009","url":null,"abstract":"<p><p>During the 2019 Chinese National Microbiological Food Safety Surveillance program, <i>Listeria monocytogenes</i> was detected in ice cream samples produced by Manufacturer A. By comparing the sequences of isolates derived from the ice cream with those of isolates derived from humans, we identified one human-derived isolate that was genetically indistinguishable from one ice cream-derived isolates. The patient was hospitalized with listeriosis in Beijing, China in March 2019. Food history obtained from the patient indicated that he had consumed ice cream produced by Manufacturer A during the 30-day period before the onset of illness. No cases of listeriosis were detected after the ice cream produced by Manufacturer A was removed from the shelves. Overall, this report presents the first case of <i>L. monocytogenes</i> infection associated with ice cream in China.</p>","PeriodicalId":12333,"journal":{"name":"Foodborne pathogens and disease","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}