Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment最新文献

{"title":"Presence of antimicrobial residues in edible pig tissues after exposure to cross-contaminated feed: a case study with sulphadimethoxine/trimethoprim.","authors":"Cristina Santos-Santórum Suárez, Pascal Sanders, Agnès Perrin-Guyomard, Michel Laurentie, Jean-François Taillandier, Marie-Pierre Lagrée, Murielle Gaugain, Alexis Viel","doi":"10.1080/19440049.2025.2467627","DOIUrl":"10.1080/19440049.2025.2467627","url":null,"abstract":"<p><p>When manufacturing oral premixes, cross-contamination may occur between medicated and non-medicated feed leading to the exposure of food-producing animals to low concentrations that may result in antimicrobial residues in edible products. This project was designed to assess the level of antibiotic residues in edible pig tissues, faeces and plasma after exposure for 12 days to feed contaminated with sulphadimethoxine/trimethoprim (2% of the therapeutic dosage). Our results show that sulphadimethoxine concentrations can significantly exceed the maximum residue limits (MRL) in liver (618 ± 96 µg/kg) and kidneys (510 ± 73 µg/kg), and that putative metabolites can also be detected in the liver. Based on tissue and plasma data, a pharmacokinetic model was developed to assess which contamination rates would not result in residue concentrations above the MRL. Our simulations show that the contamination rate should remain below 0.2% of the therapeutic dose, i.e. far lower of the tolerated contamination rate.</p>","PeriodicalId":12295,"journal":{"name":"Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment","volume":" ","pages":"418-433"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural occurrence of semicarbazide in heather honey.","authors":"Linn Fenna Groeneveld, Oksana Bekkevold, Trond Bergskås, Martin Linkogel, Cord Luellmann, Marit Almvik","doi":"10.1080/19440049.2025.2469840","DOIUrl":"10.1080/19440049.2025.2469840","url":null,"abstract":"<p><p>Regulatory bodies aim to protect consumers from harmful substances. The use of certain antibiotics is prohibited in food-producing animals in the EU due to their potential detrimental effects on humans. Among these are nitrofuran antibiotics, which degrade rapidly so that their metabolites are used as markers in screening for their illegal use. The use of one metabolite, semicarbazide (SEM), as a marker for detecting the antibiotic nitrofurazone, has been criticized due to the many pathways it can be formed by and its natural occurrence in some food items. A recent change in the reference point of action (RPA) for SEM, as stated in Commission Regulation (EU) 2019/1871, due to a reassessment of sensitivity of the analyses, poses a problem for the export of heather honey in Norway. Norwegian heather honey seems to exceed the lowered RPA in numerous cases. Here we show that Norwegian heather honey samples, but not polyfloral 'summer' honey samples from the same hives, contain SEM. The simplest explanation for the demonstrated pattern is a natural source of SEM in heather honey, not the use of a banned antibiotic. Based on our results, we propose that an exception to the EU regulation should be added, exempting heather honey derived from <i>Calluna vulgaris</i> unless other nitrofurans or their metabolites are found together with SEM.</p>","PeriodicalId":12295,"journal":{"name":"Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment","volume":" ","pages":"434-441"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143575602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Label-free fluorescence displacement sensors based on split aptamers and Thioflavin T for the rapid and sensitive detection of kanamycin in milk.","authors":"Xinyue Yin, Qi Pu, Chumeng Wang, Yuhong Xiang, Nengsheng Ye","doi":"10.1080/19440049.2025.2459219","DOIUrl":"10.1080/19440049.2025.2459219","url":null,"abstract":"<p><p>Kanamycin (KANA) plays a key role in the treatment of bacterial infections and has been widely used in animal husbandry. However, its overuse causes antibiotic residues in animal-derived foods. Determination methods for KANA are urgently needed for food safety. Most of the developed fluorescent aptamer sensors for detecting KANA use parental aptamer (kana-Apt) as recognition unit. However, excessive bases tend to form secondary structures and lead to high background or nonspecific signals. In this study, two fluorescent sensors based on one (kana1-Apt) and two (kana1/kana2-Apt) split fragments were developed for KANA detection. The LODs of the kana1-Apt/ThT system and kana1/kana2-Apt/ThT systems were 4.88 nM and 4.53 nM, respectively. In addition, satisfactory recoveries of the kana1-Apt/ThT system and kana1/kana2-Apt/ThT system were obtained in the detection of KANA in milk, which were 97.6%-104.5% and 98.4%-105.9%, respectively. Moreover, the results indicated that the kana1-Apt fragment plays a critical role in recognition. In conclusion, the results of the present study provide a novel strategy for molecular detection based on split aptamers.</p>","PeriodicalId":12295,"journal":{"name":"Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment","volume":" ","pages":"405-417"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous determination of fumonisin B₁ and B₂ in maize using a facile online pre-column derivatization HPLC method.","authors":"Nan Li, Haodong Liu, Xinyue Hu, Lingmei Niu, Yijing Zhai, Xiangdong Xu","doi":"10.1080/19440049.2025.2468793","DOIUrl":"10.1080/19440049.2025.2468793","url":null,"abstract":"<p><p>A rapid, sensitive and reliable analytical method for the simultaneous determination of fumonisin B₁ (FB₁) and fumonisin B₂ (FB₂) was developed and optimised using high performance liquid chromatography and fluorescence detection (HPLC-FLD) coupled with online pre-column derivatization using o-phthalaldehyde (OPA) and 2-mercaptoethanol (2-ME). This study focused on the optimisation of the online pre-column derivatization procedure, HPLC parameters, and sample pre-treatment. FB₁ and FB₂ in maize were extracted and purified using immunoaffinity column (IAC) and derived with OPA at room temperature. The OPA reagent was stable for 7 days, and OPA-derivatised products for 15 min. The excitation and emission wavelengths were 335 nm and 440 nm, respectively. Chromatography was performed using a C18 column and gradient elution at 1.0 mL min^-1 with acetonitrile and 0.1% acetic acid at pH 3.21. The LOD values of FB₁ and FB₂ were 0.10 and 0.26 mg kg^-1, respectively, comparable with or lower than those in other reports. The recoveries of FB₁ and FB₂ were between 85.6%-119.2%. The presented method is time-saving and robust, and successfully applied in determining FB₁ and FB₂ in maize.</p>","PeriodicalId":12295,"journal":{"name":"Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment","volume":" ","pages":"517-525"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of temperature, relative humidity, and storage time conditions on ochratoxin a production by <i>Aspergillus niger</i> fungi in dry parchment coffee.","authors":"Isabel Cristina Restrepo Salazar, Gustavo Antonio Peñuela Mesa","doi":"10.1080/19440049.2025.2459211","DOIUrl":"10.1080/19440049.2025.2459211","url":null,"abstract":"<p><p>The influence of temperature, relative humidity, and storage time on the production of Ochratoxin A by the fungus <i>Aspergillus niger</i> in dry parchment coffee was determined under controlled laboratory conditions. Additionally, the roasting curve that would achieve maximum reduction of OTA concentration in roasted coffee was evaluated. The objective was to establish strategies to reduce the risk of product contamination by this mycotoxin in coffee farms and its presence in coffee ready for consumption. For the analysis of the influence of temperature, relative humidity, and storage times on OTA production, sterilized coffee samples incubated with the <i>A. niger</i> strain were used. To obtain the roasting curves, coffee samples stored for 15 days at a temperature of 23 °C and relative humidity of 60% were employed. The OTA concentration of each study samples was quantified by ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS). The results obtained enabled: (1) The understanding of the conditions of temperature, relative humidity, and storage time that favor the production of the toxin by <i>A. niger,</i> thus allowing the development of coffee storage protocols that reduce grain contamination by this toxin, as it was found that increases in storage time and decreases in temperature and relative humidity to certain values are associated with increases in OTA concentration in the DPC. (2) Identifying the roasting curve whereby the coffee was subjected to temperatures from 180 °C to 208.8 °C for 11.23 min, achieving an OTA degradation of 76.4%. This curve serves as a guide for the adjustment of the temperatures and roasting times around the variables present in the process, achieving different roasting profiles, a significant reduction of OTA without affecting the quality of the coffee, and facilitating different chemical, physical, and organoleptic characteristics that can accommodate consumers' tastes and ensure a safe beverage.</p>","PeriodicalId":12295,"journal":{"name":"Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment","volume":" ","pages":"491-502"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Naturally occurring indole-3-acetic acid in foods: a need for review of the current risk management measures in the EU.","authors":"Nicolas Christinat, Thomas Stroheker, Flavia Badoud, Marion Ernest, Thierry Delatour, Birgit Christall, Alejandro Rodarte, Rebeca Fernandez, Olga Kuchma, Richard H Stadler","doi":"10.1080/19440049.2025.2459222","DOIUrl":"10.1080/19440049.2025.2459222","url":null,"abstract":"<p><p>Indole-3-acetic acid (IAA) is a natural plant hormone which can also be used as a plant growth regulator. However, its usage on crops is not permitted in the EU, with a maximum residue limit (MRL) currently set at 0.1 mg kg^-1 for all food commodities. As available data on the occurrence of IAA in food commodities are limited, this work aims at evaluating the amount of IAA in important food commodities such as coffee and cereals, but also selected processed ingredients such as cocoa and malt. In total, 133 samples representing 18 different food commodities were analysed for the occurrence of free IAA using a liquid chromatography high resolution mass spectrometry method. IAA was detected in all samples except malt powders and tomatoes. The analysed crops were either grown under conventional, organic, or strictly controlled (i.e. excluding the use of IAA as pesticide/plant growth regulator) farming conditions. No significant differences in the amounts of IAA were found in crops grown under the three different farming conditions. A high percentage of the samples (63%) showed levels of free IAA above the EU MRL. We therefore conclude that the natural abundance of IAA was not properly assessed prior to the establishment of some current EU MRLs. Based on the natural occurrence of IAA in a wide range of foods; we question the need for an MRL for IAA in plant-based foods.</p>","PeriodicalId":12295,"journal":{"name":"Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment","volume":" ","pages":"442-451"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection and screening of organophosphate esters in infant formula from Shanghai, China: distribution characteristics and risk evaluation.","authors":"Ruiqi Du, Jing Zhou, Shenping Zhang, Yuanyuan Chen, Bingli Lei, Xiaolan Zhang","doi":"10.1080/19440049.2025.2459218","DOIUrl":"10.1080/19440049.2025.2459218","url":null,"abstract":"<p><p>Organophosphate esters (OPEs) have raised great concerns in recent years. However, information regarding their occurrence in infant formula remains limited. Thus, thirty-two OPEs were measured in infant formula sold in Shanghai, China in 2023. The results showed that OPE occurrence in infant formula was widespread. The median concentrations of organophosphate diesters, organophosphate triesters, and total OPEs were 2.28, 5.20, and 8.63 ng/g, respectively. Tris(2-chloroisopropyl) phosphate (TCPP) showed the highest median concentration (1.95 ng/g), followed by triethyl phosphate, bis(1-chloro-2-propyl) phosphate (BCPP), tri-isobutyl phosphate, and triphenyl phosphate (0.532-0.581 ng/g). The dominant chloro-OPEs (TCPP and BCPP) were regional-specific. Compared to corresponding triesters, the diester concentrations were often lower, except for bis(2-butoxyethyl) phosphate and tributoxyethyl phosphate. Additionally, five novel OPEs with phenyl groups were identified, showing high detection frequencies and comparable concentrations to TCPP. Raw materials and food processing methods might affect individual OPEs. The estimated daily intakes (EDIs) ranged from 62.3 to 355 ng/kg bw/day. The highest EDI occurred in infants of 0-6 months of age but posed no obvious health risk for infants and toddlers. Further studies are still needed to evaluate the possible health implications arising from the novel OPEs and their metabolites, as well as the potentially synergistic effects.</p>","PeriodicalId":12295,"journal":{"name":"Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment","volume":" ","pages":"465-478"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the <i>in vitro</i> efficiency in adsorbing mycotoxins of a tri-octahedral bentonite with potential application in aquaculture feed.","authors":"Xenia Pascari, Irene Teixido-Orries, Francisco Molino, Sonia Marin, Antonio J Ramos","doi":"10.1080/19440049.2025.2459234","DOIUrl":"10.1080/19440049.2025.2459234","url":null,"abstract":"<p><p>The use of mycotoxin binders in feed products is currently the most efficient method to mitigate the harmful effects of mycotoxins. The unprecedented growth of aquaculture in recent years has led to an increased use of plant-based ingredients in fish feeds, thereby raising the risk of mycotoxin exposure. This study investigates the <i>in vitro</i> adsorption efficiency of a tri-octahedral bentonite against aflatoxin B₁ (AFB1), zearalenone (ZEN), and fumonisin B₁ (FB1) in simulated gastric (pH = 1.2) and intestinal (pH = 6.8) fluids at 25 °C, the usual body temperature in aquaculture fish species. The binder was highly effective, removing over 98% of AFB1 from both media. FB1 was completely adsorbed at pH = 1.2, while its adsorption at pH = 6.8 reached a maximum of 46.3%. ZEN binding was consistent across both pH levels, ranging from 56.1% to 69.7%. Nine equilibrium isotherm functions were fitted to the experimental data to elucidate the adsorption mechanisms. A Sips model isotherm best characterized AFB1 adsorption in simulated gastric fluid, whereas that of ZEN was best described by the Freundlich model. In simulated intestinal fluid (pH = 6.8), monolayer adsorption described by the Langmuir model provided the best fit for all three mycotoxins.</p>","PeriodicalId":12295,"journal":{"name":"Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment","volume":" ","pages":"503-516"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tiered intake assessment for propylene glycol in beverages.","authors":"Nga L Tran, Maribeth M Anderson, Maia M Jack","doi":"10.1080/19440049.2025.2449820","DOIUrl":"10.1080/19440049.2025.2449820","url":null,"abstract":"<p><p>A tiered intake assessment approach is presented and applied to derive estimates of maximum potential global propylene glycol (PG) intake from beverage sources. The US and UK markets served as surrogates for the world and the EU region, respectively, to determine the maximum potential exposure for PG in various subpopulations, including brand-loyal consumers. Conservative intake estimates for PG used in non-alcoholic beverages were calculated for toddlers less than 3 years (y), young children 3-9 y, adolescents 10-17 y, adults 18-64 y, elderly 65-74 y, very elderly 75+ y, based on assumed uses in high beverage consumption markets, leveraging either the 2-day food consumption data from the 2013-2016 US National Health and Nutrition Examination Survey or the 4-day food consumption data from the 2008-2017 UK National Diet and Nutrition Survey Rolling Programme. This study shows that safety of PG in beverages at proposed use levels up to 3,000 mg kg^-1 can be supported for any geography, based not only on a refined budget method approach but also on a refined deterministic approach when applying the proposed safe intake (pADI) of 62.5 mg kg bw^-1day^-1. In all refined assessments, intake estimates across all age groups fell close to or well below the pADI even among high consumers at the 95^th percentile.</p>","PeriodicalId":12295,"journal":{"name":"Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment","volume":" ","pages":"317-325"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geographical differentiation between South Korean and Chinese onions using stable isotope ratios and mineral content analysis.","authors":"Ayoung Lee, Jeongeun Kwon, Su-Jin Ahn, Jaesin Lee, Hyung Joo Kim","doi":"10.1080/19440049.2025.2451629","DOIUrl":"10.1080/19440049.2025.2451629","url":null,"abstract":"<p><p>Geographical origin authentication of onions has become significant owing to origin labelling fraud in South Korea. Various analytical techniques based on stable isotope ratios, organic and inorganic constituents, or their combinations, can distinguish agricultural products geographically. However, studies on the geographical classification of South Korean and Chinese onions using stable isotopes and minerals remain scarce. This study aimed to discriminate geographically between South Korean and Chinese onions using stable isotope ratios (δ¹³C, δ¹⁵N, and δ³⁴S) and mineral contents (K, Ca, Mg, Na, P, Fe, Zn, Mn, Cu, and Sr) combined with multivariate statistical analysis. Fifty-eight onion samples cultivated in South Korea and China were collected in 2023. The two stable isotope ratios (δ¹⁵N and δ³⁴S) and six minerals (K, Ca, Na, Fe, Zn, and Sr) significantly differed between these onions. These variables were applied in orthogonal partial least squares discriminant analysis to classify the onion samples regionally. The predictive ability and goodness-of-fit parameters (<i>R</i>²<i>X</i> and <i>R</i>²<i>Y</i>) were 0.671, 0.383, and 0.677, respectively. K, Sr, δ³⁴S, and Na served as potential markers contributing to the classification. Therefore, stable isotopes and mineral elements may serve as effective indicators for the geographical discrimination of South Korean and Chinese onion samples using multivariate analyses.</p>","PeriodicalId":12295,"journal":{"name":"Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment","volume":" ","pages":"281-292"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}