Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment最新文献

{"title":"The effect of breed on ivermectin residues in the edible tissues of cattle and the estimated withdrawal period.","authors":"Marina Pinheiro Lima Rosa, André Tadeu Gotardo, Ana Rita Oprimi Maramarque, Giselle Kindlein, Caroline Andrade Tomaszewski, Daniel Rodrigo Hillesheim, Graciane Fabiela da Silva, Lucas Sucheki Barnet, Renata Batista Rau, Tamara Dos Santos Castilhos, Fabiano Barreto, Silvana Lima Górniak","doi":"10.1080/19440049.2024.2423199","DOIUrl":"https://doi.org/10.1080/19440049.2024.2423199","url":null,"abstract":"<p><p>This study analyzed the residue depletion kinetics of ivermectin (IVM) in Nelore and crossbred (Nelore x Angus) cattle aiming to compare the profiles between the breeds and evaluate the residue levels at the injection site. IVM 1%, at a dose of 0.2 mg/kg, was administered <i>via</i> the subcutaneous route, and tissue samples were collected on different days post administration for analysis by LC-MS/MS. The results revealed that the detection of the marker residue in conventional matrices such as the liver, perirenal fat, and trapezius muscle (injection site) had relatively high residue concentrations. The maximum residue limit (MRL) was exceeded at the injection site at 21- and 35-days post administration in crossbred and Nelore animals, respectively, with significant variations between animals. This study highlighted significant challenges in accurately determining the pharmacokinetic profile and withdrawal periods of IVM in cattle due to high variability in tissue residue data, particularly at injection sites. The comparison of IVM concentrations between cattle breeds was hindered by high standard errors, emphasizing the need for more rigorous sampling protocols. The results suggest that current guidelines may not adequately account for the erratic depletion kinetics of injectable formulations like IVM, especially at injection sites. Therefore, improving sampling techniques and revising guidelines are essential for accurate residue monitoring and withdrawal period determination.</p>","PeriodicalId":12295,"journal":{"name":"Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment","volume":" ","pages":"1-11"},"PeriodicalIF":2.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142562703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of bisphenol S (BPS) in packaged fish, meat, cheese, and price labels on their corresponding packages.","authors":"Xu-Liang Cao, Wen-Hsuan Fu, Svetlana Popovic","doi":"10.1080/19440049.2024.2394170","DOIUrl":"10.1080/19440049.2024.2394170","url":null,"abstract":"<p><p>As an alternative to bisphenol A (BPA), bisphenol S (BPS) has been used as an ink developer in thermal paper products including price labels on food packaging which have been suggested as the sources of BPS found at high levels in packaged fish samples. BPS in the printed price labels glued onto the outside of plastic film could migrate indirectly from the printed surface through the paper, adhesive and film into the food. In order to investigate if price labels could also be the sources of BPS detected in the meat samples in our previous studies, meat and other food samples packaged under different conditions were collected, and BPS in these samples together with the price labels on the corresponding packaging were extracted with solvent followed by solid phase extraction and stable isotope dilution LC-MS/MS analysis. BPS was detected at very high levels (161.7-222.4 µg/cm²) in all the five sticker type of price labels, indicating BPS being the dominant if not the sole ink developer. BPS was also detected in all the 26 continuous roll type of price labels but at very low levels (0.017-18 ng/cm²), indicating that the dominant ink developer is likely one of the other alternatives, rather than BPS. Despite BPS being detected in all price labels on packaging of fish, meat, and cheese samples, BPS was not detected or detected in only a few fish, meat, and cheese samples at levels considerably lower than the current EU specific migration limit (SML) of 50 ng/g food for BPS authorised under Regulation (EU) 10/2011.</p>","PeriodicalId":12295,"journal":{"name":"Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment","volume":" ","pages":"1509-1515"},"PeriodicalIF":2.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contaminants and residues have varied distributions in large volumes of wheat.","authors":"Sheryl A Tittlemier, Richard Blagden, Jason Chan, Dainna Drul, Don Gaba, Mei Huang, Anja Richter, Mike Roscoe, Maria Serda, Valentina Timofeiev, Michael Tran","doi":"10.1080/19440049.2024.2417394","DOIUrl":"https://doi.org/10.1080/19440049.2024.2417394","url":null,"abstract":"<p><p>Analysis of bulk wheat consignments for naturally-occurring contaminants and residues from plant protection products is common, and helps manage potential health risks to consumers. The heterogeneous distribution of some mycotoxins in wheat has been described, however the distribution of other contaminants and residues has not yet been reported. This study characterized distributions of deoxynivalenol, ochratoxin A, ergot alkaloids, cadmium, and glyphosate in nine large consignments of wheat by analysing composite samples representing sub-lots prepared from increments obtained during the entire loading process. The widest span of concentrations within a consignment occurred for ochratoxin A (<0.5-22.9 µg/kg) and ergot alkaloids (0.009-0.486 mg/kg), followed by deoxynivalenol (<0.05-0.76 mg/kg) and glyphosate (<0.3-5.01 mg/kg), and then cadmium (0.022-0.102 mg/kg). Experimental semivariograms were plotted to model the spatio-temporal correlation of analytes within consignments during loading. Analyses demonstrated that distributions of contaminants and residues within a particular consignment differed, and that distributions of a particular contaminant or residue differed among consignments. The results indicate that sampling during only a portion of a loading or unloading process can result in a composite sample that is not representative of the consignment and thus increase the risk of misclassifying a consignment as compliant.</p>","PeriodicalId":12295,"journal":{"name":"Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment","volume":" ","pages":"1-11"},"PeriodicalIF":2.3,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-occurrence and correlation of arsenic, cadmium, and lead in processed foods intended for infants and young children: evaluation of two statistical approaches adapted to censored data and their implications for risk management.","authors":"Sarah I Murphy, Régis Pouillot, Marc Boyer, Sherri Dennis, Eileen Abt, Patrick Gray, Dwayne Jarman, Edward Nyambok, Jane M Van Doren","doi":"10.1080/19440049.2024.2414956","DOIUrl":"10.1080/19440049.2024.2414956","url":null,"abstract":"<p><p>We evaluated the co-occurrence of arsenic (As), cadmium (Cd), and lead (Pb) in 10 categories of processed foods intended for infants and young children (<2 years old) and adapted methodology to characterise and evaluate the impact of correlations on toxic element (TE) concentrations in these foods. Co-occurrence was assessed by calculating the frequency of samples having concentrations above the limit of detection (LOD) among TE sets (i.e. As-Cd, As-Pb, Cd-Pb, and As-Cd-Pb). Pairwise correlations were evaluated using two statistical approaches adapted to censored data: (i) non-parametric Kendall's tau and (ii) parametric Bayesian modelling. Nonparametric and parametric correlation analyses showed similar results. We found positive correlations among one or more pairs of the TEs (As, Pb, and Cd) in 9 of the 10 categories of foods intended for infants and young children and a negative correlation for one TE pair for a single food category. Where positive correlations are observed, removing samples with high concentrations of a given TE reduces the mean of the other TEs in that food. We also explored the impact of correlations among TEs on the fraction of the supply below maximum levels. Positive correlations among TEs have the potential to reduce the impact on the supply when setting multiple maximum levels.</p>","PeriodicalId":12295,"journal":{"name":"Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment","volume":" ","pages":"1-18"},"PeriodicalIF":2.3,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissipation and dietary risk assessment of fluoxapiprolin (and its metabolites) residues in cucumber and tomato samples under field conditions.","authors":"Nitesh S Litoriya, Ravi L Kalasariya, Kaushik D Parmar, Jignesh H Patel, Sunny H Patel, Nidhi N Chaudhary, Nirmal R Chauhan, Suchi Chawla, Paresh G Shah","doi":"10.1080/19440049.2024.2380918","DOIUrl":"10.1080/19440049.2024.2380918","url":null,"abstract":"<p><p>The present study was undertaken to understand the dissipation behaviour/kinetics of fluoxapiprolin and its metabolites in cucumber and tomato under field conditions. A QuEChERS based extraction method followed by liquid chromatography coupled to mass spectrometry (LC-MS/MS) analysis showed that all method validation parameters were within the acceptable range as per international standards with a limit of quantitation (LOQ) of 0.01 mg kg^-1 for all analytes. As significant matrix effects were observed with a few metabolites, matrix matched standards were used for the whole study. Residues of fluoxapiprolin in cucumber at standard dose were steady from 0 to 3 day after application and were below LOQ on the 5^th day after application. In cucumber fruit at double dose and in tomato at both the doses the residues followed second-order kinetics and were respectively ≤ LOQ from days 7 and 14 onwards. Pre-harvest intervals (PHI) of 5 days and 14 days are proposed for cucumber and tomato fruits respectively. All the metabolites were ≤ LOQ from day 0 in all the matrices. The consumer risk, assessed as Hazard Quotient (HQ), showed that HQ was ≤1 in all the cases. The results of the present study and earlier studies on other similar fungicides suggest that the use of fluoxapiprolin in cucumber and tomato fruits may not pose health or environmental hazards provided that good agricultural practices are followed and the proposed waiting period is observed. The data from the present study can be used by regulatory bodies in establishing maximum residue limits.</p>","PeriodicalId":12295,"journal":{"name":"Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment","volume":" ","pages":"1275-1287"},"PeriodicalIF":2.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141747854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aflatoxin M₁ levels in urine and breast milk of lactating mothers in Kuala Lumpur, Malaysia.","authors":"Alyaa Izzati Aminuddin, Rosita Jamaluddin, Mohd Redzwan Sabran, Nurul Husna Mohd Shukri","doi":"10.1080/19440049.2024.2386462","DOIUrl":"10.1080/19440049.2024.2386462","url":null,"abstract":"<p><p>Aflatoxins are carcinogens that can contaminate food and affect various body organs especially liver and kidney. When consumed, aflatoxin B₁ (AFB₁) is partially metabolised into aflatoxin M₁ (AFM₁), which is excreted in the urine. Breast milk may also contain AFM₁ due to maternal dietary intake from contaminated food. This cross-sectional study aimed to determine the levels of AFM₁ in both urine and breast milk among breastfeeding mothers (<i>n</i> = 256). The mother's demographic information was collected during recruitment. Mothers were then scheduled for an appointment to provide a morning urine sample along with five to ten mL samples of breast milk. AFM₁ levels in both samples were analysed using an enzyme-linked immunosorbent assay (ELISA). Spearman's rho and Chi-square were used to determine the associations between mean levels of AFM₁ in urine and breast milk. Findings show 68.0% of urine samples were contaminated with AFM1 (mean levels = 0.08 ± 0.04 ng/mL), while 14.8% of breast milk samples had AFM₁ (mean levels = 5.94 ± 1.81 ng/kg). Urine AFM₁ levels were not significantly associated with AFM₁ levels in breast milk (<i>p</i> > 0.05). This study can act as a baseline for future research examining long-term aflatoxin exposure among both mothers and infants.</p>","PeriodicalId":12295,"journal":{"name":"Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment","volume":" ","pages":"1360-1367"},"PeriodicalIF":2.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141874590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissipation kinetics and risk assessment of residues of combination product of two fungicides, fluxapyroxad, and pyraclostrobin in cumin.","authors":"Kaushikkumar D Parmar, Nidhi N Chaudhary, Ravi L Kalasariya, Suchi Chawla, Saurabh C Thakor, Chirag J Patel, Dasharathlal S Patel, Laljibhai F Akbari, Girdhari Lal Kumawat","doi":"10.1080/19440049.2024.2387194","DOIUrl":"10.1080/19440049.2024.2387194","url":null,"abstract":"<p><p>Supervised field trial studies were conducted to understand dissipation kinetics and harvest time residues of a combination product of fluxapyroxad and pyraclostrobin in cumin plant/leaves and seeds at different locations in India. The results showed initial accumulation of fluxapyroxad at the levels of 15.4 and 20.2 mg kg^-1 and pyraclostrobin at the level of 21.2 and 33.4 mg kg^-1 in cumin leaves/plant in Anand, Gujarat. Fluxapyroxad and pyraclostrobin followed zero-order and first-order dissipation kinetics in cumin plant/leaves samples respectively. The residues translocated to cumin seeds. As the hazard quotient (HQ) was <1 in all cases consumer health risk may be negligible.</p>","PeriodicalId":12295,"journal":{"name":"Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment","volume":" ","pages":"1288-1301"},"PeriodicalIF":2.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The occurrence and biological control of zearalenone in cereals and cereal-based feedstuffs: a review.","authors":"Hongmin Zhen, Yumeng Hu, Ke Xiong, Mengmeng Li, Wen Jin","doi":"10.1080/19440049.2024.2385713","DOIUrl":"10.1080/19440049.2024.2385713","url":null,"abstract":"<p><p>Zearalenone, a prominent mycotoxin produced by <i>Fusarium</i> spp., ubiquitously contaminates cereal grains and animal feedstuffs. The thermal stability of zearalenone creates serious obstacles for traditional removal methods, which may introduce new safety issues, or reducing nutritional quality. In contrast, biological technologies provide appealing benefits such as easy to apply and effective, with low toxicity byproducts. Thus, this review aims to describe the occurrence of zearalenone in cereals and cereal-based feedstuffs in the recent 5 years, outline the rules and regulations regarding zearalenone in the major countries, and discuss the recent developments of biological methods for controlling zearalenone in cereals and cereal-based feedstuffs. In addition, this article also reviews the application and the development trend of biological strategies for removal zearalenone in cereals and cereal-based feedstuffs.</p>","PeriodicalId":12295,"journal":{"name":"Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment","volume":" ","pages":"1344-1359"},"PeriodicalIF":2.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polychlorinated dibenzo-<i>p</i>-dioxin and dibenzofuran contamination of free-range eggs: estimation of the laying hen's soil ingestion based on a toxicokinetic model, and human consumption recommendations.","authors":"Christelle Oltramare, Markus Zennegg, Mélanie Graille, Sylvain Lerch, Aurélie Berthet, David Vernez","doi":"10.1080/19440049.2024.2384416","DOIUrl":"10.1080/19440049.2024.2384416","url":null,"abstract":"<p><p>Polychlorinated dibenzo-<i>p</i>-dioxins and dibenzofurans (PCDD/Fs) are ubiquitous in the environment. The main route of human exposure is through food consumption. Soil contamination can be problematic for sanitary safety depending on the usage of the soil, such as farming. In case of environmental soil contamination with PCDD/Fs, hen's eggs may be contaminated due to soil ingestion by hens. For this reason, it is important to understand the parameters that influence eggs' contamination when hens are raised in contaminated areas. After the discovery of a contaminated area in Lausanne (Switzerland), we collected hens' eggs from ten domestic-produced eggs and one farm. Based on PCDD/F measurements of eggs and soil, and a toxicokinetic model, we estimated individual hen's soil intake levels and highlighted appropriate parameters to predict the dose ingested. Recommended weekly consumption for home-produced eggs was calculated based on the tolerable weekly intake proposed by EFSA in 2018. The most important parameter to assess the soil ingestion does not seem to be the soil coverage by vegetation but rather the hen's pecking behaviour, the latter being difficult to estimate objectively. For this reason, we recommend using a realistic soil ingestion interval to assess the distribution of egg PCDD/F concentration from free-range hens reared on contaminated soil. The addition of soil contamination in the toxicokinetic model can then be used to recommend to the general population weekly consumption of eggs. The consumption by adults of free-range eggs produced on land with soil containing >90 ng toxic-equivalent (TEQ)/kg dry soil should be avoided. Even with a low level of soil contamination (1-5 ng TEQ/kg dry soil), we would recommend consuming not more than 5 eggs per week for adults and no more than 2 eggs for children below 4 years old.</p>","PeriodicalId":12295,"journal":{"name":"Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment","volume":" ","pages":"1302-1314"},"PeriodicalIF":2.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in acrylamide content in selected potato/sweet potato products on the Canadian market.","authors":"Zakir Hossain, Tony Zhao, Adam Becalski, Jakob Schneider, Sherry Yu Feng, Dorothea F K Rawn","doi":"10.1080/19440049.2024.2379388","DOIUrl":"10.1080/19440049.2024.2379388","url":null,"abstract":"<p><p>Processed plant-based foods, particularly high carbohydrate-containing foods, are among the greatest contributors to dietary acrylamide, a probable human carcinogen, uptake. Between 2009 and 2020, five surveys were conducted to determine acrylamide in high carbohydrate-containing foods in Canada. These surveys included sampling of potato and sweet potato chips, French fries, and frozen potato/sweet potato products, as a follow-up to our earlier surveys from 2002 - 2008. Samples were analyzed using isotope dilution (¹³C₃-acrylamide) with LC-MS/MS. The highest mean acrylamide levels were found in sweet potato chips. Among potato chips (57 to 4660 ng g^-1), one brand consistently showed the highest concentrations with wide variability. Acrylamide concentrations decreased over time in ready-to-eat French fries (from 480 to 358 ng g^-1), and one brand showed a clear reduction temporally. Wide variations were observed among brands, among lots/outlets of same brands, and among different food chains. Acrylamide levels in potato chips decreased between 2009 and 2016 (504.3 ng g^-1) relative to the period 2002 - 2008 (1096.9 ng g^-1). The acrylamide trends observed in the products measured in the latest study indicate that food producers may have adopted mitigation strategies.</p>","PeriodicalId":12295,"journal":{"name":"Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment","volume":" ","pages":"1232-1241"},"PeriodicalIF":2.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}