Presence of antimicrobial residues in edible pig tissues after exposure to cross-contaminated feed: a case study with sulphadimethoxine/trimethoprim.

IF 2.3 3区 农林科学 Q2 CHEMISTRY, APPLIED
Cristina Santos-Santórum Suárez, Pascal Sanders, Agnès Perrin-Guyomard, Michel Laurentie, Jean-François Taillandier, Marie-Pierre Lagrée, Murielle Gaugain, Alexis Viel
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Abstract

When manufacturing oral premixes, cross-contamination may occur between medicated and non-medicated feed leading to the exposure of food-producing animals to low concentrations that may result in antimicrobial residues in edible products. This project was designed to assess the level of antibiotic residues in edible pig tissues, faeces and plasma after exposure for 12 days to feed contaminated with sulphadimethoxine/trimethoprim (2% of the therapeutic dosage). Our results show that sulphadimethoxine concentrations can significantly exceed the maximum residue limits (MRL) in liver (618 ± 96 µg/kg) and kidneys (510 ± 73 µg/kg), and that putative metabolites can also be detected in the liver. Based on tissue and plasma data, a pharmacokinetic model was developed to assess which contamination rates would not result in residue concentrations above the MRL. Our simulations show that the contamination rate should remain below 0.2% of the therapeutic dose, i.e. far lower of the tolerated contamination rate.

暴露于交叉污染饲料后可食用猪组织中存在抗菌残留物:磺胺二甲氧嘧啶/甲氧苄啶的案例研究。
在生产口服预混料时,药物饲料和非药物饲料之间可能发生交叉污染,导致食用动物暴露于低浓度的抗生素中,从而可能导致食用产品中的抗菌残留物。本项目旨在评估被磺胺二甲氧嘧啶/甲氧苄啶(治疗剂量的2%)污染的饲料暴露12天后可食用猪组织、粪便和血浆中的抗生素残留水平。我们的研究结果表明,磺胺二甲氧嘧啶在肝脏(618±96µg/kg)和肾脏(510±73µg/kg)中的浓度可以显著超过最大残留限量(MRL),并且在肝脏中也可以检测到假定的代谢物。基于组织和血浆数据,开发了一个药代动力学模型,以评估哪种污染率不会导致残留浓度超过MRL。我们的模拟表明,污染率应保持在治疗剂量的0.2%以下,即远低于耐受污染率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.40
自引率
6.90%
发文量
136
审稿时长
3 months
期刊介绍: Food Additives & Contaminants: Part A publishes original research papers and critical reviews covering analytical methodology, occurrence, persistence, safety evaluation, detoxification and regulatory control of natural and man-made additives and contaminants in the food and animal feed chain. Papers are published in the areas of food additives including flavourings, pesticide and veterinary drug residues, environmental contaminants, plant toxins, mycotoxins, marine biotoxins, trace elements, migration from food packaging, food process contaminants, adulteration, authenticity and allergenicity of foods. Papers are published on animal feed where residues and contaminants can give rise to food safety concerns. Contributions cover chemistry, biochemistry and bioavailability of these substances, factors affecting levels during production, processing, packaging and storage; the development of novel foods and processes; exposure and risk assessment.
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