Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment最新文献

{"title":"Refined intake assessment of seven sweeteners via foods and beverages by the Dutch population using branded data.","authors":"Corinne Sprong, Nanette Vrijenhoek, Jan Dirk Te Biesebeek, Maryse Niekerk, Nynke Koopman, Matthijs Sam, Ivon Milder","doi":"10.1080/19440049.2025.2479865","DOIUrl":"10.1080/19440049.2025.2479865","url":null,"abstract":"<p><p>The intake of seven sweeteners (acesulfame K, aspartame, cyclamates, saccharins, steviol glycosides, sucralose (all chronic intake) and erythritol (acute intake)) <i>via</i> foods and beverages by the Dutch population was assessed in a refined assessment using branded data (product labels, use levels and consumption shares of brands) and scenarios for brand-loyalty. In general, the intake of these sweeteners was below their respective health-based guidance values (HBGVs). Only for toddlers high intakes of acesulfame K, cyclamates and erythritol were around or slightly above the HBGV in the most conservative scenario ('full brand-loyalty, consumers only'). However, intake of all sweeteners was likely overestimated due to conservative assumptions when data on the presence of sweeteners were absent. Improved information, particularly on products with a high contribution to the sweetener intake in toddlers, is needed to further refine the intake assessment. In conclusion, the intake of all sweeteners <i>via</i> foods and beverages is most likely of no concern for the Dutch population.</p>","PeriodicalId":12295,"journal":{"name":"Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment","volume":" ","pages":"539-561"},"PeriodicalIF":2.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congener-specific transfer modelling of dioxins and dioxin-like PCBs in free-ranging cattle grazing in the Dutch floodplains.","authors":"Jordi Minnema, Sylvia Notenboom, Joost Westerhout, Ron L A P Hoogenboom, Suzanne Jeurissen","doi":"10.1080/19440049.2025.2478076","DOIUrl":"10.1080/19440049.2025.2478076","url":null,"abstract":"<p><p>Cattle grazing in the Dutch floodplains are exposed to polychlorinated dibenzo-p-dioxins and dibenzofurans (dioxins) and dioxin-like PCBs (dl-PCBs) through the consumption of grass and adhering soil. This can lead to elevated dioxin and dl-PCB levels in meat fat. To manage this contamination issue, the kinetics of these compounds in cattle need to be better understood. This study describes the development and application of a physiologically based kinetic (PBK) model to predict dioxin and dl-PCB levels in muscle fat of 'Rode Geus' cattle based on measured levels in grass and soil. Calibration of the model was performed separately for each congener, using measured dioxin and dl-PCB levels in various tissues of 14 animals. Model validation performed using dioxin and dl-PCB samples of 14 other cattle, showed that PBK model predictions were on average a factor 2.4 higher than the measured dioxin and dl-PCB TEQ levels in fat. Despite this difference, the model may still be particularly useful to better understand the relation between environmental dioxin and dl-PCB levels and those in cattle. The model is publicly available with a user-friendly interface on www.feedfoodtransfer.nl and may provide relevant insights for risk assessment and risk management.</p>","PeriodicalId":12295,"journal":{"name":"Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment","volume":" ","pages":"603-620"},"PeriodicalIF":2.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bio-preservative potential of marjoram and fennel essential oil nano-emulsions against toxigenic fungi in citrus: integrating <i>in-vitro</i>, <i>in</i>-<i>vivo</i>, and <i>in</i>-<i>silico</i> approaches.","authors":"Merihane Gharzouli, Abdel Hakim Aouf, Shimaa Moawad, Hatem Ali, Tawfiq Alsulami, Amr Farouk, Karolina Hoppe, Ahmed Noah Badr","doi":"10.1080/19440049.2025.2473551","DOIUrl":"10.1080/19440049.2025.2473551","url":null,"abstract":"<p><p>Citrus fruits, known for their vibrant flavours and health benefits, are susceptible to fungal attacks, particularly from toxigenic <i>Penicillium</i> fungi, which pose a significant pre- and post-harvest hazard. However, aromatic oils and their nanoparticles may effectively address this issue. Marjoram and fennel oils, alongside their nanoparticles, were extracted, and their aromatic constituents and antimicrobial activities were evaluated. A simulated medium with fungal spores was used to assess anti-toxigenic activity, and a simulated infection experiment was conducted with orange and lemon fruits. The capacity and mechanisms of aromatic constituents were analysed through molecular docking assays targeting enzymes involved in fungal growth and mycotoxin production. The nanoparticles exhibited good stability (89.17%-92.41%) and compact formulation (density of 0.92-0.96 g/mL). Results demonstrated substantial effectiveness of nano-emulsions against toxigenic fungi, with major aromatic compounds identified as terpinene-4-ol (18%) and <i>γ</i>-terpinene (11%) in marjoram and estragole (38%) and anethole (29%) in fennel oil. Diffusion assays revealed significant anti-pathogen effects (8.33-11 mm) and antifungal activity (33.33 ± 2.88-89.33 ± 1.15 mm) of marjoram and fennel nano-emulsions. Results regarding simulated infected fruit reflect spoilage delay without impacting fruit quality or sensory. The interactions between oil or nano-emulsions and fungal enzymes showed strong binding-free energy values, with significant docking scores (-6.6 to -7.0 kcal/mol) for aromatic constituents. In conclusion, aromatic antifungals offer a promising strategy for controlling <i>Penicillium</i>, enhancing the safety and quality of oranges and lemons, with oil nanoparticles improving antifungal efficacy by significantly reducing mycelium weight and spore germination.</p>","PeriodicalId":12295,"journal":{"name":"Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment","volume":" ","pages":"632-650"},"PeriodicalIF":2.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distribution of phthalic acid esters in propolis ethanolic extract and capsuled propolis.","authors":"Rifat Nowshin Raka, Haitao Xu, Meichao Bu, Lin Zhang, Xiaofeng Xue","doi":"10.1080/19440049.2025.2487500","DOIUrl":"10.1080/19440049.2025.2487500","url":null,"abstract":"<p><p>Phthalate esters (PAEs), commonly used in food packaging materials, pose a potential health risk due to their migration into food matrices. Propolis, a resinous bee product widely consumed for its health benefits, is often packaged in plastics, raising concerns about PAE contamination. However, the occurrence of PAEs within propolis has been scarcely investigated. This study quantified PAE contamination profiles in propolis ethanolic extracts (PE) and propolis capsules (PCs) from China. The GC-MS/MS analysis of 20 PAEs demonstrated high linearity, indicating the reliability of the method. The limits of quantification (LOQ) ranged from 1.3 to 26.2 µg/kg, and the limits of detection (LOD) ranged from 0.4 to 8.6 µg/kg. Matrix effects ranged between 9% and 33%. Five PAEs were detected in PE samples: dimethyl phthalate (DMP), diethyl phthalate (DEP), diisobutyl phthalate (DiBP), dibutyl phthalate (DBP) and bis(2-ethylhexyl)phthalate (DEHP). Seventeen PAEs were detected in PC samples, with 15 consistently present in all samples (100% positivity). Diallyl phthalate (DAP), dipropyl phthalate (DPrP) and di-n-octyl phthalate (DNOP) were not detected in any sample. The total mean concentration of the 17 detected PAEs (∑17 PAEs) in the capsules ranged from 0.87 mg/kg to 23.71 mg/kg. This study found that PE and PC had the highest DBP (0.24 mg/kg) and di-heptyl phthalate (DHP: 2.29 mg/kg) levels on average, respectively. While PC showed higher PAE levels than PE. Therefore, this study provides insight into PAE contamination of raw propolis extract and encapsulated propolis.</p>","PeriodicalId":12295,"journal":{"name":"Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment","volume":" ","pages":"621-631"},"PeriodicalIF":2.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143784396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safe consumption of marine invaders: a snapshot of <i>Diadema setosum</i> contamination levels in the frame of European novel food standards.","authors":"Tamara Tavoloni, Simone Bacchiocchi, Arianna Stramenga, Melania Siracusa, Martina Ciriaci, Francesco Griffoni, Ernesto Azzurro, Arianna Piersanti","doi":"10.1080/19440049.2025.2494215","DOIUrl":"https://doi.org/10.1080/19440049.2025.2494215","url":null,"abstract":"<p><p>Consuming marine invaders is increasingly recognized as an effective strategy for controlling their populations. Following European legislation (Regulation (EU) 2015/2283 on novel foods), it is crucial to ensure that these invasive species are safe for consumption. This study presents the first screening of potential contaminants in gonad samples of <i>Diadema setosum</i>, an invasive sea urchin species, offering a snapshot of contamination levels. The study analyzed Perfluoroalkyl substances (PFASs), Polychlorinated biphenyls (PCBs), Marine biotoxins (MBs), and a broad spectrum of inorganic elements, including heavy metals. The results showed that all analyzed contaminants were significantly below the maximum limits set for regulated fishery products in Europe, though some concerns arose from the levels of cadmium (Cd) and perfluorooctanoic acid (PFOA) detected in certain specimens. These preliminary findings underscore the need for more extensive investigations into <i>D. setosum</i> contaminant levels to ensure the safety of potential consumption.</p>","PeriodicalId":12295,"journal":{"name":"Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment","volume":" ","pages":"1-12"},"PeriodicalIF":2.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the application period on glyphosate residue contamination in coffee beans.","authors":"Ana Carolina Pereira Paiva, Vanessa Lopes de Freitas, Leonardo d'Antonino, Maria Eliana Lopes Ribeiro de Queiroz, Antonio Alberto da Silva","doi":"10.1080/19440049.2025.2496282","DOIUrl":"https://doi.org/10.1080/19440049.2025.2496282","url":null,"abstract":"<p><p>The impairment of productivity and harvest of coffee beans by weeds is more accentuated when the infestation occurs between the flowering and fruiting periods of the coffee plant. However, controlling these plants with herbicides, such as glyphosate, can result in crop contamination and accumulation of the herbicide in coffee beans through the drift during application. In this sense, this work sought to determine the stage of development of the coffee crop at which the application of the herbicide glyphosate does not result in the contamination of coffee beans. Glyphosate was applied in lower doses in 5 different stages of the coffee plant, from bean formation to maturation (cherry beans), with one application per plant for each stage evaluated, in addition to the controls, which did not receive herbicide application. After complete maturation, the grains were harvested, pulped, dried, and analyzed by LC-MS/MS to determine the concentration of glyphosate. Herbicide residues were detected in four of the five selected stages, at concentrations lower than the LOQ (0.5 mg kg^-1), but were not detected in the cherry maturation stage. These results indicate the translocation of the herbicide and accumulation in the grains, compromising the quality of the commercialized grains.</p>","PeriodicalId":12295,"journal":{"name":"Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment","volume":" ","pages":"1-6"},"PeriodicalIF":2.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occurrence of quinolizidine alkaloids and phomopsin A in lupin-containing foods: a two-year survey of the Belgian market.","authors":"Sofie Schryvers, Bram Miserez, Jet Van De Steene, Mia Eeckhout, Liesbeth Jacxsens","doi":"10.1080/19440049.2025.2494729","DOIUrl":"https://doi.org/10.1080/19440049.2025.2494729","url":null,"abstract":"<p><p>Lupin is a pulse crop valued for its protein content and potential as functional ingredient, e.g. in gluten-free foods. The presence of quinolizidine alkaloids (QAs) and phomopsins (PHO) has raised concerns, yet information regarding their occurrence remains limited. A two-year screening of QAs and PHO A in lupin-containing foods available on the Belgian market was conducted, based on a market study and risk-based sampling plan (<i>n</i> = 339). A UHPLC-MS/MS method was validated for the simultaneous quantification of seven QAs (i.e. sparteine, lupanine, lupinine, 13α-OH-lupanine, angustifoline, multiflorine and albine) and phomopsin A in relevant matrices. PHO A was not detected in any of the samples (<LOD of 1.5-3.6 µg/kg). In contrast, high total QA levels (sum of seven QAs) were measured in 'Lupins (dry) and similar' (446 ± 343 mg/kg, <i>n</i> = 17), 'Lupin-based protein powder' (234 ± 135 mg/kg, <i>n</i> = 6), 'Lupin-based egg alternatives' (177 ± 195 mg/kg, <i>n</i> = 17) and 'Lupin-based coffee surrogates' (428 ± 368 mg/kg, <i>n</i> = 6). Given lupin's potential in plant-based diets, attention to QA presence is crucial, and a safe-by-design approach is recommended. A risk assessment, that considers the consumption of lupins, should indicate whether risk management measures are warranted.</p>","PeriodicalId":12295,"journal":{"name":"Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment","volume":" ","pages":"1-16"},"PeriodicalIF":2.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation into the presence of alkaloids in <i>Areca catechu-based</i> single-use food-contact articles (FCA).","authors":"J Brad Mangrum, Lowri DeJager, Tim Begley","doi":"10.1080/19440049.2025.2469271","DOIUrl":"10.1080/19440049.2025.2469271","url":null,"abstract":"<p><p>In this work, we have developed a method to investigate the presence of four alkaloids and their migration potential from single-use, biodegradable <i>Areca catechu-</i>derived dinnerware. The seeds of <i>Areca catechu</i> palm, commonly referred to as the betel nut, are known to contain high concentrations of four alkaloids: arecoline, guvacoline, areciadine, and guvacine. Migration of these alkaloids into a food simulant was determined using a single-sided migration cell. The results indicate that carboxylic acid alkaloids, arecaidine, and guvacine, preferentially migrate under the experimental conditions which mimic the conditions of use for dinnerware.</p>","PeriodicalId":12295,"journal":{"name":"Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment","volume":" ","pages":"526-538"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polybrominated diphenyl ethers (PBDEs) in US meat, poultry, and siluriformes: 2018-19 levels, trends, and estimated consumer exposures.","authors":"Sara J Lupton","doi":"10.1080/19440049.2025.2457947","DOIUrl":"10.1080/19440049.2025.2457947","url":null,"abstract":"<p><p>Human exposure to polybrominated diphenyl ethers (PBDEs), a class of brominated flame retardants, can occur through consumption of contaminated foods. Since 2007, U.S. meat and poultry samples (beef, pork, chicken, turkey) have been collected every 5 years to assess PBDE levels and consumer exposure to seven PBDEs. Mean ∑PBDE concentrations from beef, pork, chickens, turkeys, dairy cows, and siluriformes (catfish) were 0.19, 0.48, 0.11, 0.60, 0.28 ng/g lipid weight (lw), and 2.5 ng/g wet weight (ww). The ΣPBDEs for all meat classes ranged from 0.005 to 17.7 ng/g lw. Comparison of the 2018-19 survey to the 2007-08 and 2012-13 surveys revealed an overall decrease in the median ΣPBDE residue for all four meat classes with significant reductions in the medians, at 40 - 45%, for pork, chicken, and turkey. As in the previous surveys, BDEs 47 and 99 had higher percentage contributions to the ΣPBDE concentrations than other PBDE congeners, which indicated the penta-BDE formulation was a likely exposure source for animals. An estimate of U.S. consumer daily intake of PBDEs from meat and poultry was 5.0 ng/day which is a decrease from the 2012-13 survey of 6.4 ng/day.</p>","PeriodicalId":12295,"journal":{"name":"Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment","volume":" ","pages":"452-464"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time dependence of the pre-chromatographic oxidation method for bivalves contaminated with paralytic shellfish poisoning toxins.","authors":"Paulo Vale","doi":"10.1080/19440049.2025.2472360","DOIUrl":"10.1080/19440049.2025.2472360","url":null,"abstract":"<p><p>The neurotoxins of the saxitoxin family can be the origin of the human neurological syndrome of paralytic shellfish poisoning via contaminated marine bivalve vectors. A pre-chromatographic oxidation method is the official testing method in the EU, also known as the 'Lawrence method'. It involves several steps, including toxin extraction, solid-phase clean-up, and oxidation to produce fluorescent derivatives. Despite the manual peroxide oxidation involving four pipetting steps, high coefficients of determination were commonly obtained for the calibration curves of the respective toxin oxidation products. However, the 11-hydroxysulphate toxins dcGTX2 + 3, C1 + 2 and GTX2 + 3, often had slightly lower coefficients of determination (i.e. <i>R</i>² < 0.998) than their non-11-hydroxysulphate counterparts dcSTX, GTX5 and STX (i.e. <i>R</i>² > 0.998). Deviations of ±10 s from the respective standard reaction times, caused significant alterations in fluorescent yield for toxins quantified with peroxide but not for those quantified with periodate. The oxidation is an endothermal reaction, and its reaction rate is toxin-specific, with the N11-hydroxysulphate toxins having a slower reaction rate. This was confirmed by incubating GTX2 + 3 and STX at different reaction times. The incubation of toxins in a bivalve matrix also slows down the reaction in comparison with oxidation in dilute acetic acid, giving lower recoveries, as studied here in detail for dcGTX2 + 3. Circumventing the matrix effect by dilution is not possible, as 10% of matrix is enough to cause a reduction to half of the fluorescence yield of dcGTX2 + 3. When heating the N1-H toxins with peroxide, the increase in fluorescence yield is inversely proportional to the recovery values commonly found for each toxin.</p>","PeriodicalId":12295,"journal":{"name":"Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment","volume":" ","pages":"479-490"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}