Fertility and sterility最新文献

{"title":"Polycystic ovarian morphology: the number of chocolate chips is more important than the size of the cookie","authors":"Alexander M. Quaas M.D., Ph.D.","doi":"10.1016/j.fertnstert.2024.11.028","DOIUrl":"10.1016/j.fertnstert.2024.11.028","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 2","pages":"Pages 247-248"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should physicians be facilitating gestational carrier arrangements in the absence of medical indication?","authors":"Brian Levine M.D., M.S. , Alexis L. Cirel Esq. , Kate D. Schoyer M.D. , Arthur R. Derse M.D., J.D. , Robert T. Rydze M.D. , Eve C. Feinberg M.D.","doi":"10.1016/j.fertnstert.2024.11.013","DOIUrl":"10.1016/j.fertnstert.2024.11.013","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 2","pages":"Pages 201-207"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Target trial emulation of preconception serum vitamin D status on fertility outcomes: a couples-based approach","authors":"Julia D. DiTosto M.S. , Ellen C. Caniglia Sc,.D. , Stefanie N. Hinkle Ph.D. , Naria Sealy B.A. , Enrique F. Schisterman Ph.D. , Erica Johnstone M.D. , Pauline Mendola Ph.D. , James Mills M.D. , Jim Hotaling M.D. , Ginny Ryan M.D. , Sunni L. Mumford Ph.D.","doi":"10.1016/j.fertnstert.2024.08.332","DOIUrl":"10.1016/j.fertnstert.2024.08.332","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate associations between preconception 25-hydroxyvitamin D (25(OH)D) levels and biomarkers in female and male partners on live birth (LB), pregnancy loss, and semen quality.</div></div><div><h3>Design</h3><div>Secondary analysis using the folic acid and zinc supplementation trial of couples seeking infertility treatment at four US centers (2013–2017). A target trial emulation framework was applied to estimate associations. Couples were observed for 9 months or through pregnancy.</div></div><div><h3>Subjects</h3><div>Couples seeking infertility treatment.</div></div><div><h3>Intervention(s)</h3><div>Preconception concentrations of 25(OH)D (primary) and associated biomarkers: vitamin D binding protein, calcium, free vitamin D, bioavailable vitamin D.</div></div><div><h3>Main Outcome Measure(s)</h3><div>Live birth and pregnancy loss were ascertained via self-report and medical records. Semen quality was ascertained 6 months after enrollment. Log-binomial regression estimated risk ratios and 95% confidence intervals (CIs). Individual and joint models and effect measure modification by preconception body mass index were considered.</div></div><div><h3>Result(s)</h3><div>Among 2,370 couples, 19.5% of females and 29.9% of males were 25(OH)D deficient. Females with sufficient status had a 28%-higher likelihood of LB than deficient females (95% CI, 1.05–1.56). Female and male 25(OH)D status were associated with LB among those with normal body mass index (sufficient vs. deficient: female adjusted risk ratio [aRR], 1.39; 95% CI, 1.00–1.99; male aRR, 1.51; 95% CI, 1.01–2.25) and among obese female partners (sufficient vs. deficient: aRR, 1.33; 95% CI, 0.95–1.85). Couples whose both partners had higher 25(OH)D status had increased likelihood of LB (both not deficient vs. both deficient aRR, 1.26; 95% CI, 1.00–1.58). No associations were observed with pregnancy loss or semen quality. Similar results were found for all biomarkers except calcium.</div></div><div><h3>Conclusion(s)</h3><div>Preconception vitamin D status and bioavailability impact fertility among couples seeking infertility therapy, likely unrelated to semen quality. Body mass index stratified analyses demonstrated heterogeneous associations.</div></div><div><h3>Clinical Trial Registration Number</h3><div>NCT01857310.</div></div><div><div>Emulación de ensayos clínicos sobre el estado de vitamina D en suero preconcepcional y sus efectos sobre los resultados en la fertilidad: un enfoque basado en parejas.</div></div><div><h3>Objetivo</h3><div>Evaluar la asociación entre los niveles preconcepcionales de 25-hidroxivitamina D (25(OH)D) y los biomarcadores en mujeres y sus parejas varones con respecto al nacido vivo (LB), a la pérdida gestacional y a la calidad del semen.</div></div><div><h3>Diseño</h3><div>Análisis secundario del ensayo de suplementación con ácido fólico y zinc en parejas que buscaban tratamiento de infertilidad en cuatro centros de EE.UU. (2013-2017","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 2","pages":"Pages 300-312"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Criteria for the fellowship match: are we using the right parameters?","authors":"Ruben Alvero M.D. , Ruth B. Lathi M.D.","doi":"10.1016/j.fertnstert.2024.12.001","DOIUrl":"10.1016/j.fertnstert.2024.12.001","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 2","pages":"Pages 249-250"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estrogen-progestins and endometriosis-associated depression: of causation, bias, and confounding.","authors":"Noemi Salmeri, Sonia Cipriani, Paolo Vercellini","doi":"10.1016/j.fertnstert.2025.01.026","DOIUrl":"10.1016/j.fertnstert.2025.01.026","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to monitor the efficacy of ovarian stimulation for assisted reproductive technology?","authors":"Paul Pirtea, Jean Marc Ayoubi, Baris Ata","doi":"10.1016/j.fertnstert.2025.01.027","DOIUrl":"10.1016/j.fertnstert.2025.01.027","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adding short duration GnRH antagonist and gonadotropin to natural cycle frozen embryo transfer allowed scheduling of transfer day without compromising live birth.","authors":"Ali Borazjani, Kerry S J Flannagan, Jeanne E O'Brien, Phillip A Romanski, Micah Hill, Kate Devine","doi":"10.1016/j.fertnstert.2025.01.022","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.01.022","url":null,"abstract":"<p><strong>Objective: </strong>To determine if there is an association between the type of natural cycle frozen embryo transfer (natural cycle FET) [scheduled vs. traditional] and live birth outcomes.</p><p><strong>Design: </strong>Retrospective cohort of all natural cycle FETs across a single network of fertility clinics in the United States SUBJECTS: All natural cycle FETs performed in ovulatory patients between January 2019 and April 2022 EXPOSURE: Scheduled natural cycle FET cycles received a short-duration of GnRH antagonist (1 amp per day) with low dose gonadotropins (75 IU/day) to delay ovulation to enable more flexible scheduling of the FET were compared with cycles without delay (natural cycle FET group).</p><p><strong>Main outcome measure(s): </strong>Live birth RESULTS: There were a total of 1,087 natural cycle FETs that met inclusion criteria. The scheduled natural cycle FET protocol was utilized in 114 (10.5%) of these cycles. The mean age was 35 (interquartile range, IQR, 33-38). PGT-A was used in 76.3% (n=87) of scheduled natural cycle and 68.9% (n=670) of natural cycle FET cycles (p=0.11). The scheduled natural cycle FET group had a significantly higher estradiol level (318 vs. 249 pg/mL; p=0.0002) and a lower LH level (5.7 vs. 13.4 mIU/mL) at ovulatory trigger but a comparable peak endometrial thickness (9.4 vs. 9.7 mm) compared to the natural cycle FET group. Overall, there was a significant increase in positive hCG (scheduled natural cycle 81.6% vs natural cycle 64.3%; RR 1.26 (1.15-1.38)) and clinical pregnancy (scheduled natural cycle 68.4% vs natural cycle 57.1%; RR 1.21 (1.06-1.38)) in the scheduled natural cycle group. There was a higher proportion of live births in the scheduled natural cycle group, but this did not reach statistical significance (scheduled natural cycle 57.0% vs natural cycle 49.4%; RR 1.15 (0.97-1.36)). A sub-analysis of PGT-A cycles yielded similar results.</p><p><strong>Conclusions: </strong>A scheduled natural cycle FET protocol using a short duration of GnRH antagonist along with low dose gonadotropin add-back did not reduce live birth compared to traditional natural cycle FET cycles. These results suggest that this is an alternative FET protocol that may serve as a viable strategy to provide flexibility in scheduling the day of FET while still allowing a patient to undergo a natural cycle protocol. This protocol modification may enable more clinics to offer natural cycle FET.</p>","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To trigger or surge: equal outcomes in modified and true natural frozen embryo transfer (FET) cycles.","authors":"Blake Vessa, Thomas A Molinaro","doi":"10.1016/j.fertnstert.2025.01.018","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.01.018","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Will indocyanine green shed light on accessory cavitated uterine malformations?","authors":"Christopher K Arkfeld, Alexandra Huttler, Victoria Fitz","doi":"10.1016/j.fertnstert.2025.01.020","DOIUrl":"10.1016/j.fertnstert.2025.01.020","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Universal karyotyping for oocyte donors: necessary safeguard or unnecessary expense?","authors":"Daniela Diego, Heather S Hipp","doi":"10.1016/j.fertnstert.2025.01.021","DOIUrl":"10.1016/j.fertnstert.2025.01.021","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}