Fertility and sterility最新文献

{"title":"Unveiling the burden of hypoestrogenism","authors":"Seifeldin Sadek M.D. , Amanda M. Ryan M.D. , Amr S. El Haraki M.D.","doi":"10.1016/j.fertnstert.2024.11.023","DOIUrl":"10.1016/j.fertnstert.2024.11.023","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 2","pages":"Pages 241-242"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highlighting the importance of identity formation and the implications for psychological well-being among donor conceived individuals","authors":"Mary P. Riddle Ph.D.","doi":"10.1016/j.fertnstert.2024.11.027","DOIUrl":"10.1016/j.fertnstert.2024.11.027","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 2","pages":"Pages 245-246"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply of the authors","authors":"Scott M. Nelson Ph.D. , Karema Alrashid Ph.D. , Martin Shaw Ph.D. , Richard A. Anderson Ph.D.","doi":"10.1016/j.fertnstert.2024.09.019","DOIUrl":"10.1016/j.fertnstert.2024.09.019","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 2","pages":"Page 374"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increase in open-identity sperm donation in the United States since 1996","authors":"Austin Valido B.A. , Victoria Harbour M.S. , Joanna E. Scheib Ph.D.","doi":"10.1016/j.fertnstert.2024.09.012","DOIUrl":"10.1016/j.fertnstert.2024.09.012","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 2","pages":"Pages 361-363"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply of the authors: evaluating the hormonal impact of high-fat diets: gaps in gonadotropin and adrenocorticotropic hormone responses and the need for detailed fat composition analysis","authors":"Andrew P. Bradford Ph.D., Thy Nguyen B.A., Katherine Kuhn M.S., Nanette Santoro M.D.","doi":"10.1016/j.fertnstert.2024.10.005","DOIUrl":"10.1016/j.fertnstert.2024.10.005","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 2","pages":"Page 378"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Embryofetoscopy followed by hysteroscopic evacuation of a first trimester missed abortion in a woman with septate uterus","authors":"Maria Chiara De Angelis M.D. , Danilo Borrelli M.D. , Brunella Zizolfi M.D. , Alessandra Gallo M.D. , Sardo Attilio Di Spiezio M.D., Ph.D. , Jose Carugno M.D.","doi":"10.1016/j.fertnstert.2024.10.050","DOIUrl":"10.1016/j.fertnstert.2024.10.050","url":null,"abstract":"<div><h3>Objective</h3><div>To describe the technique of embryofetoscopy performed with 5Fr instruments with targeted evacuation of the gestational sac followed by a visual dilatation and curettage (D&C) using the hysteroscopic tissue removal system for the management of first trimester missed abortion in a patient with uterine septum.</div></div><div><h3>Design</h3><div>Video case-report.</div></div><div><h3>Subjects</h3><div>A 32-year-old nulliparous (G3P0020) woman with septate uterus and a 7-week missed abortion. Written informed consent was obtained from the patient.</div></div><div><h3>Exposure</h3><div>Transvaginal pelvic ultrasound revealed a 7-week missed abortion. A 3D-ultrasound confirmed the presence of a partial uterine septum. Operative hysteroscopy under spinal anesthesia was performed using a vaginoscopic approach. A partial septum was observed, and a dysmorphic gestational sac was visualized in the left hemicavity.A small incision was made in the amniotic sac using a 5Fr-bipolar electrode allowing direct visualization of the embryo. The entire embryo was removed, and selective biopsies of the chorionic villi using the hysteroscopic “grasp biopsy” technique were obtained. The residual gestational sac was removed using a 6.25 mm tissue retrieval system. No cervical dilation was required.The patient was discharged on the same day of the procedure. No intraoperative bleeding was encountered. The overall operation time was 21 minutes. A postprocedure ultrasound confirmed the presence of an empty cavity. It was determined that further evaluation of the septum was needed before proceeding with hysteroscopic metroplasty.</div></div><div><h3>Main Outcome Measure(s)</h3><div>Step-by-step demonstration of the technique and some tips and tricks for bleeding management.</div></div><div><h3>Result(s)</h3><div>Complete evacuation of the uterine cavity under direct visualization.</div></div><div><h3>Conclusion(s)</h3><div>Embryofetoscopy with miniaturized instruments allows selective targeting of trophoblastic and fetal tissues, avoiding the risk of maternal tissue contamination of the specimen. As reported in the literature, the visual D&C using tissue retrieval system could be a safe and innovative alternative for the treatment of early pregnancy loss. Compared with the use of hysteroscopic resection, tissue removal devices offer the advantage of not requiring cervical dilation and do not involve the use of electrosurgery, thus reducing damage to the uterine cavity. The combination of embryofetoscopy with visual D&C offers several advantages, especially in patients with congenital uterine anomalies, in which performing a blind D&C has a higher risk of complications.</div></div><div><div>Embrioscopia fetal seguida de evacuación por histeroscópica de un aborto retenido en el primer trimestre en una mujer con útero septado.</div></div><div><h3>Objetivo</h3><div>Describir la técnica de embrioscopia fetal realizada con instrumentos ","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 2","pages":"Pages 367-369"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulsatile gonadotropin-releasing hormone therapy: does one size fit all?","authors":"Luce A. Kassi M.D., Jennifer L. Eaton M.D., M.S.C.I.","doi":"10.1016/j.fertnstert.2024.11.026","DOIUrl":"10.1016/j.fertnstert.2024.11.026","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 2","pages":"Pages 243-244"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142762993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hormone-free vs. follicle-stimulating hormone–primed infertility treatment of women with polycystic ovary syndrome using biphasic in vitro maturation: a randomized controlled trial","authors":"Lan N. Vuong M.D., Ph.D. , Vu N.A. Ho M.D. , Anh H. Le MS.c. , Nam T. Nguyen M.D. , Toan D. Pham MS.c. , Minh H.N. Nguyen M.Sc. , Ho L. Le M.D. , Tien K. Le M.D. , Anh N. Ha M.D. , Xuyen T.H. Le M.D. , Huy H. Pham M.Sc. , Cam T. Tran MS.c. , Bao G. Huynh Ph.D. , Johan E.J. Smitz M.D., Ph.D. , Robert B. Gilchrist D.Sc.Agr. , Tuong M. Ho M.D.","doi":"10.1016/j.fertnstert.2024.09.010","DOIUrl":"10.1016/j.fertnstert.2024.09.010","url":null,"abstract":"<div><h3>Objective</h3><div>To compare oocyte maturation rates and pregnancy outcomes in women with polycystic ovary syndrome (PCOS) undergoing biphasic in vitro maturation (capacitation in vitro maturation [CAPA-IVM]) with vs. without follicle-stimulating hormone (FSH) priming.</div></div><div><h3>Design</h3><div>Randomized, controlled, assessor-blinded trial.</div></div><div><h3>Subjects</h3><div>Women aged 18–37 years with PCOS and an indication for CAPA-IVM.</div></div><div><h3>Intervention(s)</h3><div>Participants were randomized (1:1) to undergo CAPA-IVM with or without FSH priming. The FSH priming group had 2 days of FSH injections before oocyte pickup; no FSH was given in the non-FSH group. After CAPA-IVM, day-5 embryos were vitrified for transfer in a subsequent cycle.</div></div><div><h3>Main Outcome Measure(s)</h3><div>The primary endpoint was number of matured oocytes. Secondary outcomes included rates of live birth, implantation, clinical pregnancy, ongoing pregnancy, pregnancy complications, obstetric and perinatal complications, and neonatal complications.</div></div><div><h3>Result(s)</h3><div>The number (interquartile range) of matured oocytes did not differ significantly in the non-FSH vs. FSH group (13 [9–18] vs. 14 [7–18]; absolute difference –1 [95% confidence interval –5 to 4]); other oocyte and embryology outcomes did not differ between groups. Rates of ongoing pregnancy and live birth were 38.3% in the non-FSH group and 31.7% in the FSH group (risk ratio for both outcomes: 1.21, 95% confidence interval 0.74–1.98). Maternal complications were infrequent and occurred at a similar rate in the two groups; there were no preterm deliveries before 32 weeks gestation.</div></div><div><h3>Conclusion(s)</h3><div>These findings open the possibility of a new, hormone-free approach to infertility treatment of women with PCOS.</div></div><div><h3>Clinical Trail Registration Number</h3><div>NCT05600972.</div></div><div><div>Tratamiento de infertilidad sin uso de hormonas vs. preparado de hormona folículo estimulante en mujeres con síndrome de ovario poliquístico sometidas a maduración in vitro bifásica: un ensayo controlado aleatorizado</div></div><div><h3>Objetivo</h3><div>Comparar las tasas de maduración de ovocitos y los resultados del embarazo en mujeres con síndrome de ovario poliquístico (SOP) sometidas a maduración in vitro bifásica (maduración in vitro de capacitación [CAPA-IVM]) con y sin preparado de hormona folículo estimulante (FSH).</div></div><div><h3>Diseño</h3><div>Ensayo aleatorizado, controlado, con evaluador ciego.</div></div><div><h3>Contexto</h3><div>Hospital privado.</div></div><div><h3>Pacientes</h3><div>Mujeres de 18 a 37 años con SOP e indicación de CAPA-IVM.</div></div><div><h3>Intervención</h3><div>Las participantes fueron asignadas al azar (1:1) para someterse a CAPA-IVM con o sin preparado de FSH. El grupo con FSH recibió 2 días de inyecciones de FSH antes de la recolección de ovocitos; no se administró FSH e","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 2","pages":"Pages 253-261"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the hormonal impact of high-fat diets: gaps in gonadotropin and adrenocorticotropic hormone responses and the need for detailed fat composition analysis","authors":"Meihua Zheng Ph.D. , Juan Tang Ph.D.","doi":"10.1016/j.fertnstert.2024.09.037","DOIUrl":"10.1016/j.fertnstert.2024.09.037","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 2","pages":"Page 377"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generation of epithelial-stromal assembloids as an advanced in vitro model of impaired adenomyosis-related endometrial receptivity","authors":"Christina Anna Stratopoulou Ph.D. , Margherita Rossi M.S. , Chloé Beaussart M.D. , Margherita Zipponi M.S. , Alessandra Camboni M.D., Ph.D. , Jacques Donnez M.D., Ph.D. , Marie-Madeleine Dolmans M.D., Ph.D.","doi":"10.1016/j.fertnstert.2024.08.339","DOIUrl":"10.1016/j.fertnstert.2024.08.339","url":null,"abstract":"<div><h3>Objective</h3><div>To create a novel, more advanced in vitro model of human endometrium, using so-called assembloids, looking to explore endometrial receptivity in adenomyosis.</div></div><div><h3>Design</h3><div>Evaluation of assembloid responsiveness to hormonal stimulation by immunohistochemistry, enzyme-linked immunosorbent assay, and scanning electron microscopy.</div></div><div><h3>Subjects</h3><div>Twelve women, six of whom were affected by adenomyosis.</div></div><div><h3>Exposure</h3><div>Organoids (in the form of glandular fragments) and stromal fibroblasts were collected from endometrial biopsies. The two populations were combined inside an extracellular matrix to create 3D assembloids, which were then exposed to hormonal stimulation (β-estradiol for 48 hours, followed by β-estradiol/progesterone/cyclic adenosine monophosphate for 72 hours) to mimic the window of implantation.</div></div><div><h3>Main Outcome Measure(s)</h3><div>Glycodelin, leukemia inhibitory factor (LIF), and homeobox A10 (HOXA10) expression, prolactin secretion, and pinopode development.</div></div><div><h3>Result(s)</h3><div>Endometrial organoids and stromal cells were successfully isolated from women with and without adenomyosis and combined to generate the assembloid model. On stimulation, assembloids from both groups acquired a more secretory phase-like phenotype, as demonstrated by histology, and were shown to be positive for glycodelin, LIF, and HOXA10 by immunohistochemistry. Adenomyotic assembloids expressed significantly lower levels of LIF and HOXA10 within the stromal compartment after stimulation than did healthy assembloids in the same condition. Enzyme-linked immunosorbent assay revealed prolactin secretion in vitro, showing an upward trend in hormonally treated assembloids from both healthy and affected women. By scanning electron microscopy, fully formed pinopodes were discerned on the epithelial surface of healthy assembloids after stimulation, but they were absent in case of adenomyosis.</div></div><div><h3>Conclusion(s)</h3><div>Primary assembloids can be generated from endometrial biopsies from both healthy subjects and women affected by adenomyosis. These assembloids are amenable to hormonal stimulation and mimic secretory phase-specific characteristics of endometrial tissue in vivo, including glycodelin, LIF, and HOXA10 expression, and pinopode formation. Assembloids from adenomyosis appear to be less sensitive to hormonal treatment, showing reduced expression of LIF and HOXA10 in the stromal compartment and failing to form pinopodes. All in all, endometrial assembloids may serve as an advanced preclinical model of adenomyosis-related impaired endometrial receptivity, opening up new horizons in understanding and treating the condition.</div></div><div><h3>Título</h3><div>Generación de asembloides epiteliales-estromales como modelo avanzado in vitro de receptividad endometrial alterada relacionada con adenomiosis</div></div><div><h3>Obj","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 2","pages":"Pages 350-360"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142092587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}