Fertility and sterility最新文献

{"title":"Corrigendum to \"Minimum number of mature oocytes needed to obtain at least one euploid blastocyst according to female age in in vitro fertilization treatment cycles\" (Fertil Steril 2024;122:658-66).","authors":"Cristina Rodríguez-Varela,Juan Manuel Mascarós,Elena Labarta,Noelia Silla,Ernesto Bosch","doi":"10.1016/j.fertnstert.2025.04.017","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.04.017","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"14 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refining GLP-1RA Therapy in PCOS: Addressing Phenotypic, Racial, and Pharmacologic Heterogeneity.","authors":"Shengyue Jin","doi":"10.1016/j.fertnstert.2025.05.160","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.05.160","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"34 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to \"Use of ethinyl estradiol to reverse the antiestrogenic effects of clomiphene citrate in patients undergoing intrauterine insemination: a comparative, randomized study\" (Fertil Steril 2020;73: 85-89).","authors":"","doi":"10.1016/j.fertnstert.2025.05.144","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.05.144","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"45 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clarifying Chaotic Embryos: Emerging Evidence.","authors":"Jessica R Zolton","doi":"10.1016/j.fertnstert.2025.05.162","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.05.162","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"QUANTITATIVE ULTRASOUND MEASUREMENT OF UTERINE CONTRACTILITY IN SEPTATE UTERUS VERSUS NORMAL UTERI: A MULTICENTER PROSPECTIVE STUDY.","authors":"Brunella Zizolfi, Connie Odette Rees, Mariateresa Musone, Fabiola Nardelli, Virginia Foreste, Yizhou Huang, Anyi Cheng, Massimo Mischi, Benedictus Christiaan Schoot, Attilio Di Spiezio Sardo","doi":"10.1016/j.fertnstert.2025.05.159","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.05.159","url":null,"abstract":"<p><strong>Objective: </strong>To study the differences in uterine contractility in women with septate uterus compared to women with normal uterus throughout the menstrual cycle using a quantitative two-dimensional transvaginal ultrasound (TVUS) speckle tracking method.</p><p><strong>Design: </strong>A multicenter prospective observational study was carried out from February 2023 to July 2024.</p><p><strong>Subjects: </strong>Fifty-seven patients with a diagnosis of septate uterus and seventy-one patients with a normal uterus, all of reproductive age, were enrolled at the Gynecology Departments of the University of Naples Federico II (Italy) and the Catharina Hospital in Eindhoven (Netherlands).</p><p><strong>Exposure: </strong>A four-minute two-dimensional transvaginal ultrasound video in a median sagittal section of the uterus was performed throughout the various phases of the menstrual cycle to evaluate uterine contractility features, using a speckle tracking algorithm.</p><p><strong>Main outcome measure(s): </strong>Uterine contractility features were analyzed in all patients diagnosed with a septate uterus, including contraction frequency (in contractions per minute), amplitude, direction, median velocity (mm/sec), and coordination measured in Mean Squared Error (MSE).</p><p><strong>Result(s): </strong>Regardless of the cycle phase, patients with a septate uterus exhibited statistically significant trends of decreased contraction frequency, velocity, and amplitude, along with poorer contraction coordination, compared to patients with normal uterus. In the luteal phase, when contractions are typically quiescent to facilitate embryo implantation, an increase in contraction frequency (1.27 ± 0.21 vs. 1.10 ± 0.12, p=0.040), contraction velocity in posterior wall from cervix to fundus (0.90 ± 0.23 vs. 0.70 ± 0.09, p=0.027), contraction velocity in posterior wall from fundus to cervix (0.91± 0.23 vs 0.71 ± 0.08, p=0.012) and a decrease in contraction coordination (0.41 ± 0.16 vs 0.20 ± 0.08, p=0.006) were reported in septate uteri. Furthermore, when considering two subgroups - partial and complete septate uterus compared to normal uteri - data indicated a greater impairment of uterine contractility in partial septate uteri when compared to normal uteri.</p><p><strong>Conclusion(s): </strong>The presence of uterine pathologies such as a septate uterus may alter uterine peristalsis. A deeper understanding of uterine peristalsis in congenital anomalies could illuminate the link between the septate uterus and infertility.</p>","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Live Birth Rate Outcomes Following a Change in Endometrial Preparation After a Failed Frozen Embryo Transfer Cycle.","authors":"Maren Bettermann,Rachel Mejia,Karen Summers,Amy Sparks","doi":"10.1016/j.fertnstert.2025.05.157","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.05.157","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"4 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Five Miscarriages with Transcervical Embryoscopy.","authors":"Pinar Calis,Gurkan Bozdag,Mehmet Erdem,Ahmet Erdem,Deniz Karcaaltincaba","doi":"10.1016/j.fertnstert.2025.05.156","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.05.156","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"15 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144130749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endometriosis: one name, many presentations.","authors":"Ceana H Nezhat, Adam Pyrzak","doi":"10.1016/j.fertnstert.2025.05.155","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.05.155","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orally active GnRH antagonists: Are we witnessing a revolution in oral contraception?","authors":"Richard J Paulson","doi":"10.1016/j.fertnstert.2025.05.153","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.05.153","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"137 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced maternal age was associated with an annual decline in reproductive success despite use of donor oocytes: A retrospective study.","authors":"Patricia Sebastian-Leon,Francisco Jose Sanz,Pietro Molinaro,Antonio Pellicer,Patricia Diaz-Gimeno","doi":"10.1016/j.fertnstert.2025.05.150","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.05.150","url":null,"abstract":"OBJECTIVETo study if there is an increasing risk of poor reproductive outcomes associated with age in IVF patients using donor oocytes and when it becomes clinically relevant.DESIGNMulticenter, retrospective cohort study SUBJECTS: IVF patients ≥35 years at 19 private fertility clinics in Spain.EXPOSUREA single day 5 embryo from a donor oocyte (<35 years) transferred to the IVF patient undergoing a hormone replacement therapy, between February 2000 and September 2022.MAIN OUTCOME MEASURESLive birth, implantation failure, and pregnancy loss rates were analyzed using a continuous scale of women's ages to determine the gradual effect of age that is clinically relevant. The relative risks of pregnancy loss and implantation failure after 40 years of age were calculated adjusting for body mass index, IVF cycle parameters, and the embryo's developmental stage and euploidy.RESULTSAnalysis of 33,141 good-quality, single embryo transfers identified the maternal age where reproductive rates worsened as 39, 40 and 43 years for implantation failure, live birth, and pregnancy loss rates, respectively. Before live birth rates drastically decreased, there was no significant increment in the relative risk for negative outcomes (p-value>0.05). Nevertheless, after the age of 40, the relative risk of implantation failure increased by 4.2% per year (RR = 1.042, 95% CI: 1.028-1.056; p-value <0.0001) while that of pregnancy loss increased by 3.2% per year (RR = 1.032, 95% CI: 1.013-1.051; p-value = 0.0007).CONCLUSIONChallenging traditional paradigms that embryo factors drive the detrimental effect of age on reproductive outcomes, this study reveals that uterine age may also play a significant role in age-related detrimental effects. Given that embryo factors were controlled for, these findings suggest that the worsening of reproductive outcomes associated to the effects of age in the uterus. In addition, this study design identified the specific age at which the live birth rate decreases, and implantation failure rate and pregnancy loss rate increases. Our results encourage further study of how uterine age annually impacts pregnancy rates and support the uterus becoming a potential target for antiaging therapies aiming to improve outcomes of assisted reproductive technologies.","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"45 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}