{"title":"Vitamin D levels in couples undergoing in vitro fertilization treatment: lack of association with embryo quality or pregnancy rates","authors":"","doi":"10.1016/j.fertnstert.2024.06.023","DOIUrl":"10.1016/j.fertnstert.2024.06.023","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the potential impact of vitamin D (VD) serum levels on couples going through in vitro fertilization treatment in terms of embryo quality and pregnancy rates.</div></div><div><h3>Design</h3><div>A retrospective cohort study.</div></div><div><h3>Setting</h3><div>A private human reproduction center.</div></div><div><h3>Patient(s)</h3><div>A total of 267 couples underwent intracytoplasmic sperm injections between January 2017 and March 2019.</div></div><div><h3>Intervention(s)</h3><div>The couples were categorized into four groups on the basis of 25-hydroxy VD (25OHD) levels measured at the beginning of the stimulation protocol: group 1 with 25OHD levels <strong>≥</strong>30 ng/mL for both women and men; group 2 with 25OHD levels <30 ng/mL for both; group 3 women with 25OHD levels <30 ng/mL and men with 25OHD levels ≥30 ng/mL; and group 4 with women with 25OHD level <strong>≥</strong>30 ng/mL and men with 25OHD level <30 ng/mL.</div></div><div><h3>Main Outcome Measure(s)</h3><div>We consider the quantity and quality of embryos during the cleavage as well as blastocyst stages as primary outcomes. Correspondingly, the clinical pregnancy rate (CPR) was regarded as a secondary outcome.</div></div><div><h3>Result(s)</h3><div>Our findings revealed no significant correlations between the studied VD groups and the evaluated outcomes. This includes the quantity and quality of embryos during the cleavage and blastocyst stages, as well as the CPR. Primary analysis revealed a small but statistically significant difference in the duration of controlled ovarian stimulation between group 1 and group 2 (95% confidence interval, 0.07–3.04) and between group 1 and group 3 (95% confidence interval, 0.05–3.23).</div></div><div><h3>Conclusion(s)</h3><div>The present study found no correlation between the studied VD levels and the quantity as well as quality of cleavage or blastocyst stage embryos, nor did it show any impact on CPRs. Further well-designed, prospective studies are warranted to determine whether and how vitamin D affects reproductive outcomes.</div></div><div><div>Niveles de vitamina D en parejas sometidas a tratamiento de fecundación in vitro: falta de asociación con la calidad del embrión o las tasas de embarazo</div></div><div><h3>Objetivo</h3><div>Investigar el impacto potencial de los niveles séricos de vitamina D (VD) en parejas que se someten a un tratamiento de fertilización in vitro en términos de calidad embrionaria y tasas de embarazo.</div></div><div><h3>Diseño</h3><div>Estudio de cohorte retrospectivo.</div></div><div><h3>Lugar</h3><div>Centro privado de reproducción humana.</div></div><div><h3>Paciente(s)</h3><div>Un total de 267 parejas se sometieron a inyecciones intracitoplasmáticas de espermatozoides entre enero de 2017 y marzo de 2019.</div></div><div><h3>Intervención(es)</h3><div>Las parejas se clasificaron en cuatro grupos en función de los niveles de 25-hidroxi VD (25OHD) medidos al i","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141534102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gamete and embryo donation guidance","authors":"","doi":"10.1016/j.fertnstert.2024.06.004","DOIUrl":"10.1016/j.fertnstert.2024.06.004","url":null,"abstract":"<div><div>This document provides the latest recommendations for the evaluation of potential sperm, oocyte, and embryo donors, as well as their recipients, incorporating recent information about optimal screening and testing for sexually transmitted infections, genetic diseases, and psychological assessments. This revised document incorporates recent information from the US Centers for Disease Control and Prevention, the US Food and Drug Administration, and the American Association of Tissue Banks, with which all programs offering gamete<span> and embryo donation services must be thoroughly familiar, and replaces the document titled ”Recommendations for gamete and embryo donation: a committee opinion,” last published in 2013.</span></div></div><div><div>Guía para la donación de gametos y embriones</div><div>Este documento proporciona las recomendaciones más recientes para el estudio de candidatos a donación de semen, de ovocitos y de embriones, así como de sus receptores, incorporando información actualizada sobre el cribado y las pruebas óptimas para enfermedades de transmisión sexual, genéticas y evaluaciones psicológicas. Este documento revisado incluye información reciente de los Centros para el Control y la Prevención de Enfermedades de EE. UU., la Administración de Alimentos y Medicamentos de EE. UU. y la Asociación Americana de Bancos de Tejidos, con la cual todos los programas que ofrezcan servicios de donación de gametos y embriones deben estar completamente familiarizados. Este documento reemplaza al titulado \"Recomendaciones para la donación de gametos y embriones: una opinión del comité\", publicado por última vez en 2013.</div></div>","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141544678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intraoperative transvaginal ultrasound to standardize bowel endometriosis shaving","authors":"","doi":"10.1016/j.fertnstert.2024.07.496","DOIUrl":"10.1016/j.fertnstert.2024.07.496","url":null,"abstract":"<div><h3>Objective</h3><div>To study the use of intraoperative transvaginal ultrasound after bowel endometriosis shaving.</div></div><div><h3>Design</h3><div>Stepwise demonstration with a narrated video footage of preoperative and intraoperative ultrasound to evaluate the extent of an endometriotic rectal nodule.</div></div><div><h3>Setting</h3><div>Lausanne University Hospital and Geneva University Hospital.</div></div><div><h3>Patient(s)</h3><div>Two women with symptomatic endometriosis rectal lesion.</div></div><div><h3>Intervention(s)</h3><div>Preoperative transvaginal ultrasound was performed to measure the rectal nodule. After completing bowel shaving, the surgeon conducted both clinical and sonographic evaluations of the rectal wall. Clinically, this was performed using laparoscopic grasping forceps and sonographically with a transvaginal probe after filling the pelvis with saline solution.</div></div><div><h3>Main Outcome Measure(s)</h3><div>Assessment of the rectal wall for residual disease after bowel shaving and evaluation of the necessity for additional bowel resection.</div></div><div><h3>Result(s)</h3><div>After sonographic evaluation of the rectal wall, the surgeon decided in both patients to perform a discoid resection because of the presence of a residual rectal disease despite thorough bowel shaving.</div></div><div><h3>Conclusion(s)</h3><div>Intraoperative transvaginal ultrasound after bowel endometriosis shaving is a promising technique that is safe, reproducible, and efficient. It aids surgeons in accurately assessing the extent of excision of deep rectosigmoid infiltrating endometriosis and determining the necessity of additional bowel resection to reduce recurrence risk. Moreover, intraoperative ultrasound provides precise measurements of residual nodules, enabling differentiation between persistent, recurrent, or new lesions during follow-up.</div></div><div><div>Uso del Ultrasonido transvaginal intraoperatorio para estandarizar la resección de la endometriosis intestinal</div></div><div><h3>Objetivo</h3><div>Estudiar el uso del ultrasonido transvaginal intraoperatorio después de la resección de la endometriosis intestinal.</div></div><div><h3>Diseño</h3><div>Demostración paso a paso con un video narrado del uso preoperatorio e intraoperatorio del ultrasonido transvaginal en la evaluación de la extensión de un nódulo rectal endometriósico.</div></div><div><h3>Lugar</h3><div>Hospital Universitario de Lausana y Hospital Universitario de Ginebra.</div></div><div><h3>Paciente(s)</h3><div>Dos pacientes con endometriosis intomática rectal.</div></div><div><h3>Intervención(es)</h3><div>Se realizó ecografía transvaginal preoperatoria para medir el nódulo rectal. Después de completar la resección intestinal, el cirujano realizó evaluaciones clínicas y ecográficas de la pared rectal. Clínicamente, esto se realizó usando fórceps de agarre laparoscópico y ecográficamente con una sonda transvaginal después de llenar la pelvis con soluc","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A survey study evaluating donor gamete utilization rates, patient satisfaction, and fertility treatment outcomes according to desired race and ethnicity","authors":"","doi":"10.1016/j.fertnstert.2024.06.017","DOIUrl":"10.1016/j.fertnstert.2024.06.017","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate donor gamete utilization, patient satisfaction, and fertility treatment outcomes of patients pursuing treatment with donor gametes stratified by the desired race as well as ethnicity of the gamete donor.</div></div><div><h3>Design</h3><div>Survey study.</div></div><div><h3>Setting</h3><div>Clinic.</div></div><div><h3>Patient(s)</h3><div>Patients planning to undergo treatment using donor sperm and/or donor oocytes at a single academic fertility clinic in the Southeastern United States between 2015 and 2020.</div></div><div><h3>Intervention(s)</h3><div>None.</div></div><div><h3>Main Outcome Measure(s)</h3><div>Utilization rates of donor gametes, satisfaction with donor gamete selection, and fertility treatment outcomes stratified by race and ethnicity of patient, as well as that of their gamete donor.</div></div><div><h3>Result(s)</h3><div>Four hundred fifty patients were eligible for inclusion and 170 (38%) responded to the survey. Among the respondents, 59% desired a non-Hispanic White gamete donor and 20% desired a non-Hispanic Black gamete donor. Patients seeking a non-Hispanic Black gamete donor had lower odds of using donor gametes (Odds ratio [OR], 0.13; 95% confidence interval [CI], 0.04–0.40) compared with individuals seeking a non-Hispanic White gamete donor. When evaluating satisfaction with donor gamete selection, patients seeking a non-Hispanic Black gamete donor reported lower satisfaction compared with individuals seeking a non-Hispanic White gamete donor (OR, 0.19; 95% CI, 0.09–0.43). When evaluating fertility outcomes, Non-Hispanic Black patients and those using non-Hispaninc Black gamete donors were found to have lower odds of successful conception compared with non-Hispanic White patients (OR, 0.18; 95% CI, 0.07–0.46) and individuals seeking non-Hispanic White gamete donors (OR, 0.26; 95% CI, 0.09–0.75), respectively.</div></div><div><h3>Conclusion(s)</h3><div>Patients seeking non-Hispanic Black donor gametes have lower utilization rates, less satisfaction with gamete donor selection, and lower odds of conception when compared with those seeking non-Hispanic White gamete donors. These findings highlight the need for more racial diversity within donor gamete banks, as well as within the donor pools available through agencies and fertility clinics.</div></div><div><div>Un estudio de encuesta evaluando tasas de utilización de gametos donados, satisfacción del paciente, y resultados de tratamientos de fertilidad de acuerdo a la raza y etnicidad deseada</div></div><div><h3>Objetivo</h3><div>Evaluar la utilización de los gametos donados, satisfacción del paciente, y los resultados de pacientes que siguen un tratamiento con donantes de gametos estratificados por la raza deseada así como la etnicidad del donante de gametos.</div></div><div><h3>Diseño</h3><div>Estudio de encuesta.</div></div><div><h3>Lugar</h3><div>Clínica.</div></div><div><h3>Paciente (s)</h3><div>Pacientes planeando seguir un trat","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141467276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Confirmation and pathogenicity of small copy number variations incidentally detected via a targeted next-generation sequencing–based preimplantation genetic testing for aneuploidy platform","authors":"","doi":"10.1016/j.fertnstert.2024.07.008","DOIUrl":"10.1016/j.fertnstert.2024.07.008","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the technical accuracy, inheritance, and pathogenicity of small copy number variants (CNVs) detected by a targeted next-generation sequencing–based preimplantation genetic testing for aneuploidy (PGT-A) platform.</div></div><div><h3>Design</h3><div>Retrospective observational study performed between 2020 and 2022.</div></div><div><h3>Setting</h3><div>Clinic.</div></div><div><h3>Patient(s)</h3><div>A total of 12,157 patients who underwent clinical PGT-A performed by targeted next-generation sequencing for whole chromosome and large segmental aneuploidies.</div></div><div><h3>Intervention(s)</h3><div>An incidental finding was reported when a CNV gain/loss of at least 3 consecutive amplicons appeared in at least 2 embryos from the same in vitro fertilization cycle.</div></div><div><h3>Main Outcome Measure(s)</h3><div>The primary outcome measures were the specificity, incidence, inheritance, and pathogenicity of small CNVs detected by the PGT-A platform. Accuracy of the PGT-A platform CNV calls was assessed via concordance with the CNV calls (size and genomic location) on chromosomal microarray of the gamete provider(s). Parental origin of the CNV and pathogenicity classifications were also reported.</div></div><div><h3>Result(s)</h3><div>An incidental finding that met reporting criteria was identified in 75 (0.62%; 95% confidence interval, 0.5%–0.8%) of 12,157 unique PGT-A patients. Chromosomal microarray follow-up was requested for all cases, and results were received for 1 or both members of 65 reproductive couples. In all cases, 1 of the gamete providers was confirmed to have the CNV identified in the embryos (100.0%, N = 65/65; 95% confidence interval, 94.5–100). The identified CNV was of maternal origin in 34 cases (52.3%) and of paternal origin in 31 cases (47.7%). A significant correlation was identified between PGT-A–predicted CNV sizes and chromosomal microarray detected sizes (r = 0.81) and genomic coordinates on parental deoxyribonucleic acid. Twenty-six (40%) of the CNVs were classified as benign/likely benign, 30 (46.2%) as a variant of uncertain significance, and 9 (13.8%) as pathogenic/likely pathogenic.</div></div><div><h3>Conclusion(s)</h3><div>Certain PGT-A platforms may enable the detection of inherited, small CNVs with extremely high specificity without prior knowledge of parental status. Most CNVs in this data set were confirmed to be benign/likely benign or a variant of uncertain significance. Pathogenic/likely pathogenic CNVs associated with a broad range of phenotypic features may also be detected, although a reliable negative predictive value for small CNVs with current PGT-A technologies is unknown because of the many technical challenges.</div></div><div><div>Confirmación y patogenicidad de pequeñas variaciones en el número de copias detectadas incidentalmente mediante una plataforma de pruebas genéticas preimplantacionales para aneuploidía basada en secuenciación de próxima generaci","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141598914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A commentary on: “Association of serum uric acid with women’s ovarian reserve: observational study and Mendelian randomization analyses”","authors":"","doi":"10.1016/j.fertnstert.2024.07.022","DOIUrl":"10.1016/j.fertnstert.2024.07.022","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141758025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Donor incentives revisited.","authors":"Eric A Widra","doi":"10.1016/j.fertnstert.2024.10.002","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2024.10.002","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"When should assisted reproductive technology workups be performed: following a tiered approach or all on day 1?","authors":"","doi":"10.1016/j.fertnstert.2024.04.035","DOIUrl":"10.1016/j.fertnstert.2024.04.035","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140851661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Seminal plasma exposure in in vitro fertilization cycles: “Dripping water hollows out stone, not through force but through persistence”","authors":"","doi":"10.1016/j.fertnstert.2024.07.016","DOIUrl":"10.1016/j.fertnstert.2024.07.016","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141747808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}