Fertility and sterility最新文献

{"title":"(Exploration of relevant factors related to the relationship between polycystic ovary syndrome and sexual response.).","authors":"Di Xiao, Jun Li, Yaling Li","doi":"10.1016/j.fertnstert.2025.03.023","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.03.023","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Premature Ovarian Insufficiency and the Risk of Breast Cancer: Author Reply.","authors":"","doi":"10.1016/j.fertnstert.2025.03.019","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.03.019","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Special considerations in assisted reproductive technology for patients with cardiovascular disease.","authors":"Sarah C Cromack, Vanessa Kalinowska, Christina E Boots, Marla A Mendelson","doi":"10.1016/j.fertnstert.2025.03.021","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.03.021","url":null,"abstract":"<p><p>Many individuals with cardiovascular disease can benefit from the availability of assisted reproductive technologies (ART) for family building. Its use for this population may be due to underlying infertility, a need for fertility preservation prior to disease worsening or heart transplant, a genetic cardiac condition they hope to avoid passing to offspring, or the need to utilize a gestational surrogate in the setting of cardiovascular contraindications to pregnancy. Cardiovascular disease exists on a spectrum, from mild and common diseases that pose minimal threat to maternal health during pregnancy, to severe and rare diseases with a high risk of morbidity and maternal mortality if ART or pregnancy are pursued. In this review, we will characterize the varying cardiovascular diseases from the lens of the reproductive-aged patient undergoing ART. We will classify the necessary steps in the pre-ART evaluation from the multi-disciplinary team, discuss risk stratification prior to ART treatment and possible subsequent pregnancy, and offer specific evidence-based guidance on the care of these patients during the in vitro fertilization and embryo transfer cycles.</p>","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetics of Male Infertility: Where have we been and where are we going?","authors":"Michael L Eisenberg","doi":"10.1016/j.fertnstert.2025.03.016","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.03.016","url":null,"abstract":"<p><p>This month's Views and Reviews provides a detailed review of the genetics of male infertility including tests that are currently utilized and their origins as well as newer tests that can improve care for our patients. Krausz et al examines the structure and function of the Y chromosome from the first links to spermatogenesis to implications today for reproduction and health. Dr. Lamb reviews the male karyotype and the myriad of numerical or structure anomalies reported and best practices for patient management. Hwang et al reviews data on several genetic syndromes with a male reproductive phenotype and examines diagnostic and management challenges and options. Finally, Held et al examines the emerging genetics of male genital development and the implications for male fertility. All providers caring for an infertile couple will benefit from a deeper understanding of the genetic testing of the male partner.</p>","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"If a little is great and a lot is better, then way too much is just about right.","authors":"Pietro Bortoletto, Phillip Romanski","doi":"10.1016/j.fertnstert.2025.03.017","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.03.017","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy outcomes are compromised in obese women with PCOS after transfer of a single frozen-thawed euploid embryo.","authors":"Satu Kuokkanen, Sebastian Geraci, Meredith Akerman, Lubna Pal","doi":"10.1016/j.fertnstert.2025.03.018","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.03.018","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Syndromes Leading to Male Infertility: A Systematic Review.","authors":"Lucille G Cheng, Sherry L Huang, Kathleen Hwang","doi":"10.1016/j.fertnstert.2025.03.014","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.03.014","url":null,"abstract":"<p><p>Male-factor infertility is a multifactorial, complex, and increasingly common condition, of which genetic factors have more frequently been implicated in. Not only are the causal relationships between genetic variation and male infertility phenotypes understudied, but also the differences in frequency of disease-causing genetic alterations within different geographic and ethnic groups. Guidelines remain inconsistent as to recommended genomic testing during the male infertility workup. Our current fund of knowledge limits our diagnostic capability where the etiology of male infertility remains idiopathic in about 40% of patients, despite advances in genomic sequencing and testing.</p>","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Racial and ethnic differences in gestational carriers: Assessment of obstetric characteristics and outcomes.","authors":"Aaron D Masjedi, Zachary S Anderson, Laurel S Aberle, Katherine V Erickson, Jennifer A Yao, Shinya Matsuzaki, Rachel S Mandelbaum, Joseph G Ouzounian, Richard J Paulson, Koji Matsuo","doi":"10.1016/j.fertnstert.2025.03.015","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.03.015","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of medically assisted reproduction and the risk of multiple live birth across sexual orientation groups-results from a national longitudinal cohort.","authors":"Brent Monseur, Tabor Hoatson, Kodiak R S Soled, Colleen A Reynolds, S Bryn Austin, Sebastien Haneuse, Ruth B Lathi, Juno Obedin-Maliver, Brittany M Charlton","doi":"10.1016/j.fertnstert.2025.03.012","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.03.012","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibition of ovulation and pharmacologic mechanism of action of relugolix combination therapy.","authors":"I J M Duijkers, C Klipping, C Draeger, B S Schug, R-S Wedemeyer, Y Li, J C Arjona Ferreira, E M Migoya","doi":"10.1016/j.fertnstert.2025.03.011","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.03.011","url":null,"abstract":"<p><strong>Objective: </strong>To assess the effects of relugolix combination therapy on ovarian function in healthy, ovulatory, premenopausal women.</p><p><strong>Design: </strong>This was an open-label, single-cohort, pharmacodynamic, safety and tolerability study consisting of five study periods: a Pre-Treatment Period to confirm ovulatory status, three 28-day treatment periods, and a Post-Treatment Period to assess duration of time required to return to ovulation following treatment discontinuation. Ovarian function was assessed by transvaginal ultrasonography and serum hormone concentrations.</p><p><strong>Subjects: </strong>Healthy, premenopausal female participants, 18-35 years of age.</p><p><strong>Intervention/exposure: </strong>Relugolix combination therapy (relugolix 40 mg, with estradiol 1 mg and norethindrone acetate 0.5 mg) was taken orally once daily for 84 days.</p><p><strong>Main outcome measures: </strong>The primary endpoint was the proportion of women in whom ovulation was inhibited during the entire 84-day treatment period. Secondary endpoints included proportion of women in whom ovulation was inhibited within each treatment period, number of women who fulfilled the Landgren criterion; characterization of follicular diameter, hormone concentrations, and endometrial thickness; time to return to ovulation following treatment discontinuation; proportion of women who returned to ovulation within 36 days following treatment discontinuation; safety and tolerability.</p><p><strong>Results: </strong>Seventy women were enrolled in the study, 67 of whom completed treatment. Treatment with relugolix combination therapy inhibited ovulation in 100% of women who completed treatment (95% confidence interval: 94.6, 100.0). Systemic concentrations of luteinizing hormone and follicle-stimulating hormone were suppressed and maintained at low concentrations during treatment, with an absence of a preovulatory luteinizing hormone surge. Median estradiol concentrations across all women were consistently maintained between 36.8 and 39.1 pg/mL (range: 12.1-121.1 pg/mL) during treatment. All individual progesterone concentrations during treatment remained below 1.57 ng/mL (5 nmol/L). Following treatment discontinuation, all women ovulated or initiated menses. The mean time to return to ovulation was 23.5 days. Treatment was generally well tolerated with no safety or tolerability issues identified.</p><p><strong>Conclusion: </strong>Relugolix combination therapy inhibits ovulation, which, in the context of this study, was achieved within the first cycle following treatment initiation. The rapid and predictable return of ovarian activity and ovulation following treatment discontinuation is advantageous for patients who wish to conceive thereafter.</p>","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}