Fertility and sterility最新文献

{"title":"Increasing Endometrial Thickness up to 12mm Is Associated with Increased Odds of Live Birth Among Fresh and Frozen-Thawed Autologous Transfers with or without PGT.","authors":"Julian A Gingold,Haotian Wu,Harry Lieman,Manvinder Singh,Sangita Jindal","doi":"10.1016/j.fertnstert.2025.04.032","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.04.032","url":null,"abstract":"OBJECTIVETo evaluate the impact of endometrial thickness on live birth among autologous assisted reproduction cycles.DESIGNRetrospective cohort SUBJECTS: All women undergoing autologous cycles with transfers in 2016-2018 reported to the Society for Assisted Reproductive Technology.EXPOSUREEndometrial thickness on the day of ovulation trigger in fresh cycles and closest to embryo transfer in frozen-thawed cycles MAIN OUTCOME MEASURES: Relative risk of live birth across endometrial thicknesses was compared with an 8-11.9mm reference range. Estimates were adjusted for age, BMI, smoking, infertility etiology, AMH and FSH with log-binomial regression by generalized estimating equations. Fresh transfers, frozen-thawed transfers without preimplantation genetic testing and frozen-thawed transfers with preimplantation genetic testing were analyzed separately.RESULTS182,784 patients underwent 261,266 combined retrieval and transfer cycles. Patients with endometrium <8mm were slightly older, with lower BMI, higher rates of prior pregnancy loss, diminished ovarian reserve and ovulation disorders besides polycystic ovarian syndrome but lower rates of male or unexplained infertility. When all fresh and frozen-thawed transfers were combined, live birth rate increased with endometrial thickness from 31.2% (<6mm) to 34.4% (6-6.9mm) to 40.8% (7-7.9mm) to 45.0% (8-11.9mm) to 46.4% (12-14.9mm) to 46.2% (≥15mm). For fresh cycles without preimplantation genetic testing, thinner endometrium was associated with reduced live birth rate compared with the 8-11.9mm reference range (adjusted relative risk 0.59 (95% CI 0.48-0.72), 0.66 (0.58-0.74), 0.79 (0.74-0.84) for thickness <6mm, 6-6.9mm and 7-7.9mm), while 12-14.9mm and ≥15mm thickness were associated with increased live birth rate (adjusted relative risk 1.12 (1.09-1.15) and 1.16 (1.12-1.22)). Similar but less dramatic effects were noted for frozen-thawed cycles without preimplantation genetic testing (adjusted relative risk 0.87 (0.77-0.99), 0.79 (0.73-0.85), 0.94 (0.91-0.97), 1.06 (1.03-1.08) and 1.04 (0.98-1.1) for thickness <6mm, 6-6.9mm, 7-7.9mm, 12-14.9mm, and ≥15mm) and frozen-thawed cycles with preimplantation genetic testing (adjusted relative risk 0.67 (0.59-0.77), 0.80 (0.76-0.85), 0.89 (0.87-0.92), 1.07 (1.05-1.1), and 1.06 (1-1.11) for thickness <6mm, 6-6.9mm, 7-7.9mm, and 12-14.9mm and ≥15mm).CONCLUSIONIncreasing endometrial thickness from 5 to 8mm is associated with clear increases in live birth rate, but improvements are still seen until approximately 12mm, including frozen-thawed cycles with preimplantation genetic testing.","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"93 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply of the author to \"A Critical Appraisal of Obstetric Outcomes Post-Myomectomy: Addressing Methodological Gaps\".","authors":"Perrine Ginod,Ahmad Badeghiesh,Haitham Baglaf,Michael H Dahan","doi":"10.1016/j.fertnstert.2025.04.030","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.04.030","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"24 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143893410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Special considerations in assisted reproductive technology for patients with hematologic disease.","authors":"Joshua A Ewy,Suneeta Senapati,Nadia D Ali,Clarisa R Gracia","doi":"10.1016/j.fertnstert.2025.04.029","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.04.029","url":null,"abstract":"Populations with hematologic disorders seeking fertility care often present with a complex clinical picture, including disease-specific sequelae and comorbid conditions. Limited literature exists to help guide fertility clinics on the management of these patients, many of whom require multidisciplinary care coordination centered on patient-specific fertility goals. Thanks to advancements in life-prolonging therapies for hematologic disorders, growing numbers of affected individuals are seeking assisted reproductive technologies (ART) for family building. Thus, it is important to be aware of the unique considerations and risks of ART for these populations and develop evidence-based care guidelines to optimize outcomes.","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"42 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Risk analysis of torsion and malignancy for adnexal masses during pregnancy\" (Fertil Steril 2009;91:1895-902).","authors":"Chih-Feng Yen,Shu-Ling Lin,William Murk,Chin-Jung Wang,Chyi-Long Lee,Yung-Kuei Soong,Aydin Arici","doi":"10.1016/j.fertnstert.2025.03.020","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.03.020","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"35 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Addition of Operative Hysteroscopy to Vacuum Aspiration for the Management of Early Pregnancy Loss After In Vitro Fertilization\": [Fertil Steril 2024;122:1134-43.].","authors":"Kai-Lun Hu,Jie Zhao,Mingmei Lin,Xiaoye Wang,Linjing Qi,Huan Liu,Dan Mo,Zhonghong Zeng,Ben W Mol,Rong Li","doi":"10.1016/j.fertnstert.2025.03.029","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.03.029","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"35 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143872067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The number of autologous, vitrified mature oocytes needed to obtain three euploid blastocysts increases with age.","authors":"Amalia Namath,Kerry Flannagan,Paul Pirtea,James P Toner,Kate Devine","doi":"10.1016/j.fertnstert.2025.04.023","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.04.023","url":null,"abstract":"OBJECTIVETo determine the number of mature oocytes required to make at least three euploid blastocysts DESIGN: Retrospective cohort study SUBJECTS: All patients at a multi-center assisted reproductive technology (ART) practice that warmed vitrified autologous oocytes for IVF from 2011 to October 2023 EXPOSURE: Warming oocytes.MAIN OUTCOME MEASURE(S)Number of mature (MII) oocytes to achieve at least three euploid blastocysts.RESULTS1,041 thaw cycles from 986 patients were analyzed. Patients were stratified by age at vitrification. Measures of ovarian reserve decreased with advancing age, as expected. Number of mature oocytes (MII) banked and euploid blastocysts available decreased as age at vitrification increased. Patients aged 35-40 used preimplantation genetic testing more than those older than 40 or younger than 35. To optimize the chance of a potential live birth by banking at least three euploid blastocysts, patients less than 35 at vitrification needed a mean of 15 MIIs. This number doubled in patients 38 or older and tripled for patients older than 40. We also analyzed potential live birth per number of MII banked, which also increased with age, with 0.13 expected live births per thawed MII oocyte at less than 35, and 0.04 expected live births if older than 40 at time of oocyte vitrification. Age at vitrification was more influential than indication for vitrification for expected outcome of live birth.CONCLUSIONFrom previously published literature, 3 euploid blastocysts provided a 93% chance of a child. From our analysis, patients required an average of 15 mature oocytes to yield at least 3 euploid blastocysts if they were less than 35 at time of vitrification. The required number of MII doubled in patients aged 38 and older, and tripled in those 40 and older, to achieve the same goal. Given our results, we should encourage egg freeze patients to cryopreserve before age 38. We should also counsel patients that multiple vitrification cycles will likely be required to achieve a high probability of live birth from future oocyte thaws for women aged 38 or older.","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"15 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143884992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shifting the Focus for Fertility and Reproductive Health to Medical Students: A Survey Study Building on Lessons from Surgical Trainees.","authors":"Sylvie Bowden,Maitri Panchal,Angela Pochakom,Selphee Tang,Amy Metcalfe,Shu Foong","doi":"10.1016/j.fertnstert.2025.04.021","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.04.021","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"7 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do young patients with male factor benefit from preimplantation genetic testing for aneuploidy? Insights from a secondary analysis.","authors":"Molly Kornfield,Sanjana Kulkarni","doi":"10.1016/j.fertnstert.2025.04.025","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.04.025","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"35 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistence of hypertension after pregnancy-related hypertensive disorders in women with polycystic ovary syndrome.","authors":"Stefano Palomba,Flavia Costanzi,Rossella Cannarella,Raffaella Votino,Aldo E Calogero,Fabrizio Signore,Donatella Caserta","doi":"10.1016/j.fertnstert.2025.04.026","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.04.026","url":null,"abstract":"OBJECTIVEThis study aims to assess whether polycystic ovary syndrome (PCOS) increases the risk of persistent hypertension in women with a history of pregnancy-induced hypertensive disorder (PHD).DESIGNA single-center, prospective cohort study.SUBJECTSA total of 124 patients with PHD were enrolled. PHD was diagnosed based on the presence of pregnancy-induced hypertension (PIH) or preeclampsia (PE). All PHD patients were screened for PCOS diagnosis, which was confirmed or excluded based on patient history and clinical reports. Sixty-two patients diagnosed with PCOS (n=62, cases) were included as the study group. After one-to-one matching process based on age-, body mass index-, and infertility treatment, 62 control patients without PCOS were also included.EXPOSUREPCOS diagnosis according to National and International criteria.MAIN OUTCOME MEASURESThe primary outcome was the persistence of hypertension 12 months after delivery. Secondary outcomes included persistence of hypertension at 3 and 6 months from delivery, pregnancy complications and data on antihypertensive treatment.RESULTSAfter 12 months from delivery, the risk of persistent hypertension was significantly higher in PHD patients with PCOS compared to controls (adjusted odds ratio [aOR] 4.51, 95% confidence interval [CI] 1.43-14.19, p=0.010). At 6 months, that risk was also significantly higher (aOR 5.01, 95% CI 1.63-15.94, p=0.005). Additionally, pregnant PCOS patients had an earlier onset of PHD (30.0 vs. 31.1 weeks, p=0.013), required a higher dose of nifedipine (37.5 mg vs. 30 mg, p=0.001), and were more likely to receive antihypertensive therapy with multiple drugs (24.2% vs. 9.7%, p=0.032) compared to controls. The incidence of fetal growth restriction (19.4% vs. 6.5%, p=0.033), abnormal Doppler velocimetry (16.1% vs. 4.8%, p=0.041), and cesarean delivery (35.5% vs. 19.4%, p=0.019) was also significantly higher in the PCOS group compared to controls.CONCLUSIONPCOS is associated with an increased risk of persistent hypertension in patients with a history of PHD. Preventive interventions before pregnancy, specific pregnancy surveillance, and long-term follow-up should be recommended for women with PCOS.","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"8 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cumulative pre-trigger progesterone levels are not superior to single-day levels for predicting a failed cycle in fresh embryo transfer cycles.","authors":"Meghan Yamasaki,Kerry Flannagan,David Boedeker,Shelley Dolitsky,Nicole Banks,Alan Decherney,Eduardo Hariton,Benjamin S Harris,Anthony Imudia,Caleb Kallen,Jessica Kanter,Michael Levy,Phillip Romanski,Meike Uhler,Kate Devine,Micah Hill","doi":"10.1016/j.fertnstert.2025.04.024","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.04.024","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"45 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}