Fertility and sterility最新文献

{"title":"Effect of tamoxifen on the size of existing leiomyomas in postmenopausal women with breast cancer.","authors":"Dong-Yun Lee,Sung Eun Kim,DooSeok Choi","doi":"10.1016/j.fertnstert.2025.10.008","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.10.008","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"11 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145277304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Good science and engineering: Unravelling the black box of implantation.","authors":"Ruben Alvero","doi":"10.1016/j.fertnstert.2025.10.010","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.10.010","url":null,"abstract":"Human implantation has historically been difficult to characterize because of ethical and practical issues. Animal models have been helpful but are often species-specific and not reflective of human implantation. Collaboration between engineers and physician-scientists has resulted in novel in vitro models that can be helpful for direct observation of normal and abnormal human processes.","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"57 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145277303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of no zona pellucida on reproductive outcomes in vitrified-warmed euploid blastocyst transfer cycles.","authors":"Junshun Fang,Linjun Chen,Weihua Jiang,Xiaoping Ye,Qiaoyun Huang,Ningyuan Zhang,Lihua Zhu,Haixiang Sun,Shanshan Wang","doi":"10.1016/j.fertnstert.2025.10.003","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.10.003","url":null,"abstract":"OBJECTIVETo evaluate the impact of the absence of the zona pellucida on clinical, obstetric, and perinatal outcomes in vitrified-warmed euploid blastocyst transfer cycles.DESIGNRetrospective cohort study.SUBJECTSThis retrospective study included data from 1,024 preimplantation genetic testing-frozen embryo transfer cycles, conducted at a tertiary academic medical center between March 2016 and December 2021.EXPOSUREVitrified-warmed single euploid blastocyst transfers were classified into zona pellucida-intact (unexposed; n=761) and zona pellucida-free (exposed; n=263) groups. Frozen embryo transfer cycles in the zona pellucida-free group were matched with those in the zona pellucida-intact group at a 1:1 ratio using propensity score matching.MAIN OUTCOME MEASURESThe primary outcome was live birth. Secondary outcomes were clinical pregnancy, miscarriage, obstetric outcomes including cesarean delivery and gestational age, as well as perinatal outcomes including birth weight and birth defects.RESULTSBefore propensity score matching, the zona pellucida-free group exhibited significantly lower rates of clinical pregnancy (51.71% vs. 63.73%, P=0.001) and live birth (44.11% vs. 56.64%, P<0.001), as well as a higher rate of cesarean delivery (81.03% vs. 70.30%, P=0.018). However, these differences were no longer statistically significant (clinical pregnancy, 53.52% vs. 54.46%, P>0.05; live births, 45.54% vs. 49.77%, P>0.05; cesarean delivery, 80.41% vs. 74.53%, P>0.05) after matching. Multivariate analysis revealed that the embryo development stage (day 6 vs. day 5: odds ratio=0.70, P=0.029) and blastocyst quality (poor vs. good: odds ratio=0.47, P<0.001) were significant predictors of live birth. Furthermore, maternal age (odds ratio=1.09, P=0.003) and endometrial thickness (odds ratio=0.83, P=0.015) were significantly associated with the likelihood of a cesarean delivery.CONCLUSIONThe absence of the zona pellucida did not independently affect clinical, obstetric, or perinatal outcomes in vitrified-warmed single euploid blastocyst transfers. Criteria for embryo selection, particularly developmental stage and quality, were critical determinants of successful pregnancy outcomes.","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"52 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145261621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reproductive Potential of Abnormal Embryos with Whole Chromosome and Segmental Aneuploidies Diagnosed by NGS based PGT-A.","authors":"Mitko Madjunkov,Rina Abramov,Prati Sharma,Ari Baratz,Karen Glass,Svetlana Madjunkova,Clifford Librach","doi":"10.1016/j.fertnstert.2025.10.007","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.10.007","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"105 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145261623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interobserver Agreement of the FIGO Classification for uterine fibroids.","authors":"Cibele Luna,Yamile Blain,Julieta Aristizabal,Haleh Amirian,Patrizio Pasquale,Jose Carugno,Prasoon Mohan,Francesco Alessandrino","doi":"10.1016/j.fertnstert.2025.09.037","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.09.037","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"15 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145261625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minipuberty as a Window into the Reproductive Future for Girls with Turner Syndrome: Is the Image Clear?","authors":"Kathryn Blew,Kelly Acharya,Tara Streich-Tilles","doi":"10.1016/j.fertnstert.2025.09.039","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.09.039","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"102 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145261646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of endometriosis, adenomyosis and related symptoms among female offspring according to conception by assisted reproductive technologies.","authors":"Maria C Magnus,Dena Treider Alavi,Sunniva Nydal,Abigail Fraser,Deborah A Lawlor,Kim Christian Danielsson,Siri E Håberg,Hans Ivar Hanevik","doi":"10.1016/j.fertnstert.2025.10.002","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.10.002","url":null,"abstract":"OBJECTIVETo study the relationship between conception by ART and risk of endometriosis/adenomyosis in female offspring.DESIGNNational registry-based cohort study.SUBJECTSWe studied 449,611 female offspring born in Norway between 1991 and 2006 who were still alive and residing in Norway when they were 15 years of age using a national registry linkage.EXPOSUREConception by ART.MAIN OUTCOME MEASURESThe risk of endometriosis/adenomyosis and related symptoms (menstrual pains, pain during intercourse, and heavy menstrual bleedings) in female offspring conceived by ART compared with those not conceived by ART, was studied using a Cox-regression, adjusting for maternal characteristics, including age, parity, history of endometriosis/adenomyosis and country of birth.RESULTSFemale offspring conceived by ART had a higher risk of endometriosis/adenomyosis compared to those not conceived by ART (adjusted HR 1.49; 95% CI: 1.14 to 1.94). We also observed an increased risk of seeking healthcare for menstrual pains (adjusted HR 1.11; 95% CI: 1.02 to 1.21), pains during intercourse (adjusted HR 1.36; 95% CI: 1.12 to 1.65), and heavy menstrual bleedings (adjusted HR 1.31; 95% CI: 1.14 to 1.51) among female offspring conceived by ART. When we compared offspring not themselves conceived by ART to mothers with a history of using ART and offspring not conceived by ART to mothers with no history of use of ART, we observed no difference in the risk of endometriosis/adenomyosis or related symptoms.CONCLUSIONFemale offspring conceived by ART have an increased risk of endometriosis/adenomyosis and related symptoms. Additional studies are needed to replicate our findings and to further explore potential underlying mechanisms.","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"24 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145261647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low return to care rates amongst women who underwent oocyte cryopreservation for oncological indications: A SART data analysis.","authors":"Alison J Meyers,Yuval Fouks,Pietro Bortoletto,Alan S Penzias,Denny Sakkas,Denis A Vaughan","doi":"10.1016/j.fertnstert.2025.09.038","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.09.038","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"154 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145261620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy resulting from IVF/ICSI does not affect the ability of IgG transplacental transfer.","authors":"Caiyi Huang,Nijie Li,Jie Li,Dongli Huang,Huiyuan Liu,Jiaxin Wu,Chun Ma,Qiuxia Chen,Meiqiong Fan,Yu Gao,Xiaoyan Liang","doi":"10.1016/j.fertnstert.2025.10.001","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.10.001","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"8 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145261622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D Binding Protein and Reproductive Outcomes.","authors":"Iris Tien-Lynn Lee,Andrew N Hoofnagle,Richard S Legro,Michael P Diamond,Nathanael Koelper,Stephen A Krawetz,Samantha F Butts","doi":"10.1016/j.fertnstert.2025.09.036","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.09.036","url":null,"abstract":"OBJECTIVELittle is known about whether D binding protein (DBP) plays a role in reproductive outcomes. The few existing studies have largely presumed that any effects of DBP are due to its modulation of vitamin D bioavailability per the \"free hormone theory\" despite its many vitamin D-independent functions. This study therefore aimed to comprehensively evaluate the association between DBP concentration/haplotype and reproductive outcomes in patients with polycystic ovary syndrome (PCOS) or unexplained infertility undergoing ovarian stimulation.DESIGNRetrospective cohort study, secondary analysis of randomized controlled trials Pregnancy in Polycystic Ovary Syndrome II (PPCOS II) and Assessment of Multiple Intrauterine Gestations from Ovarian Stimulation (AMIGOS).SUBJECTS376 participants with PCOS (PPCOS II), 505 participants with unexplained infertility (AMIGOS).INTERVENTION OR EXPOSUREDBP concentration; DBP Gc1f, Gc1s, Gc2 haplotypes.MAIN OUTCOME MEASURESPrimary: live birth. Secondary: early pregnancy loss; composite of preterm delivery, preeclampsia, and fetal growth restriction.RESULTS881 participants were included. There was no association between DBP concentration, Gc1s, or Gc2 and live birth. When adjusting for age, race, BMI, 25(OH)D concentration, and treatment arm, the Gc1f haplotype was associated with increased odds of live birth (adjusted odds ratio [aOR] 1.49, 95% CI 1.06-2.09, p=0.02) and decreased odds of early pregnancy loss (aOR 0.46, 95% CI 0.25-0.86, p=0.02). There was no association with obstetric complications (aOR 0.76, 95% CI 0.39-1.47, p=0.42).CONCLUSIONSThe Gc1f haplotype of DBP was associated with increased odds of live birth and decreased odds of early pregnancy loss independent of 25(OH)D and DBP concentration. As Gc1f results in the DBP variant with the greatest binding affinity for vitamin D, these findings challenge the current narrative that associations between DBP and reproductive outcomes are primarily due to modulation of vitamin D bioavailability. Additional studies are needed to investigate other mechanisms for the role of DBP in reproductive outcomes.","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"39 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145235552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}