Ricardo P. Bertolla Ph.D., H.C.L.D./A.B.B. , J. Richard Pilsner Ph.D., M.P.H.
{"title":"All too often overlooked: a growing case for routine male clinical fertility examination","authors":"Ricardo P. Bertolla Ph.D., H.C.L.D./A.B.B. , J. Richard Pilsner Ph.D., M.P.H.","doi":"10.1016/j.fertnstert.2024.12.030","DOIUrl":"10.1016/j.fertnstert.2024.12.030","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 3","pages":"Pages 394-395"},"PeriodicalIF":6.6,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142925978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jacques Donnez, Christian M Becker, Mandy Mangler, Maciej Paszkowski, Tomasz Paszkowski, Julien St-Pierre, Raluca Ionescu-Ittu, Mitra Boolell, Elke Bestel, Satoshi Hori, Felice Petraglia
{"title":"Linzagolix rapidly reduces heavy menstrual bleeding in women with uterine fibroids: an analysis of the PRIMROSE 1 and 2 trials.","authors":"Jacques Donnez, Christian M Becker, Mandy Mangler, Maciej Paszkowski, Tomasz Paszkowski, Julien St-Pierre, Raluca Ionescu-Ittu, Mitra Boolell, Elke Bestel, Satoshi Hori, Felice Petraglia","doi":"10.1016/j.fertnstert.2024.12.031","DOIUrl":"10.1016/j.fertnstert.2024.12.031","url":null,"abstract":"<p><strong>Objective: </strong>To study the timing of the effect of linzagolix, an oral gonadotropin-releasing hormone receptor antagonist, on significant reduction in heavy menstrual bleeding (HMB) in women with uterine fibroids.</p><p><strong>Design: </strong>The study used pooled data from PRIMROSE 1 and PRIMROSE 2, two double-blind, similar placebo-controlled trials of linzagolix in the United States and Europe, respectively. Eligible participants were randomized equally across four treatment arms (linzagolix 100 mg and 200 mg, with and without concomitant hormonal add-back therapy [ABT] consisting of 1-mg estradiol and 0.5-mg norethisterone acetate) and one placebo arm. The cumulative incidence of achieving clinically significant HMB reduction and maintaining it to week 24 was compared between the linzagolix arms and the placebo arm using the Kaplan-Meier plots adjusted for confounding by race and study (PRIMROSE 1 vs. PRIMROSE 2).</p><p><strong>Subjects: </strong>The PRIMROSE trials randomized 1,012 women aged ≥18 years with ultrasound-confirmed uterine fibroids and HMB.</p><p><strong>Intervention: </strong>Linzagolix (100 mg and 200 mg, with and without hormonal ABT) vs. placebo.</p><p><strong>Main outcome measures: </strong>The main outcome of this analysis was the time to achievement of clinically significant HMB reduction and its maintenance up to week 24.</p><p><strong>Results: </strong>The onset of action in achieving and maintaining clinically significant HMB reduction was significantly more rapid for the linzagolix treatment arms than for the placebo arm, with a median time of <4 weeks for most linzagolix doses (except 100 mg alone). The fastest onset was seen with linzagolix 200 mg with or without ABT doses, with a median time of only 3 days. The cumulative incidence of achieving clinically significant HMB reduction by week 4 and maintaining it to week 24 was also significantly higher for the linzagolix treatment arms than for the placebo arm. Specifically, across four linzagolix treatment arms, 23.2%-68.1% achieved clinically significant HMB reduction by week 4 and maintained it to week 24 vs. 7.8% for the placebo arm.</p><p><strong>Conclusion: </strong>Linzagolix was associated with a quick effect on reducing clinically significant HMB compared with placebo. Linzagolix, thus, offers a novel noninvasive treatment approach for the rapid management of HMB symptoms in patients with uterine fibroids.</p>","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142926531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Questioning accepted knowledge, can it help reduce unintended pregnancy?","authors":"Anita L. Nelson M.D.","doi":"10.1016/j.fertnstert.2025.01.001","DOIUrl":"10.1016/j.fertnstert.2025.01.001","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 3","pages":"Page 403"},"PeriodicalIF":6.6,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kathryn Schmiech, Mengmeng Li, Lucy X Chen, Mark P Dow, Valerie L Baker
{"title":"Association of endometrial thickness with live birth rate: a study using the Society for Assisted Reproductive Technology Clinic Outcome Reporting System.","authors":"Kathryn Schmiech, Mengmeng Li, Lucy X Chen, Mark P Dow, Valerie L Baker","doi":"10.1016/j.fertnstert.2024.12.032","DOIUrl":"10.1016/j.fertnstert.2024.12.032","url":null,"abstract":"<p><strong>Objective: </strong>To assess the relationship between endometrial thickness (EMT) and live birth rates (LBRs) in fresh embryo transfer and frozen embryo transfer (FET) with and without preimplantation genetic testing (PGT).</p><p><strong>Design: </strong>Retrospective cohort study using the Society for Assisted Reproductive Technology Clinic Outcome Reporting System.</p><p><strong>Subjects: </strong>Autologous in vitro fertilization fresh embryo transfer and FET cycles initiated in 2019-2020.</p><p><strong>Exposure: </strong>Endometrial thickness measured in millimeters.</p><p><strong>Main outcome measures: </strong>Live birth rate.</p><p><strong>Results: </strong>A total of 244,001 embryo transfer cycles met the inclusion criteria (100,419 FET cycles with PGT, 96,249 FET cycles without PGT, and 47,333 fresh embryo transfer cycles). An increase in EMT was associated with an increase in LBR among all cycle types until a threshold of 9 mm, after which there was minimal increase in LBR. Before 9 mm, each 1-mm increase in EMT was associated with a relative increase in the odds of live birth by 19% for FET with PGT (adjusted odds ratio [aOR], 1.19; 95% confidence interval [CI], 1.66-1.22), 13% for FET without PGT (aOR, 1.13; 95% CI, 1.09-1.16), and 15% for fresh embryo transfer (aOR, 1.15; 95% CI, 1.09-1.20).</p><p><strong>Conclusion: </strong>The LBR increased with an increase in EMT for fresh and frozen transfers with or without PGT until a threshold of 9 mm, beyond which the LBR plateaued. There was no thickness above 9 mm associated with a decrease in LBR.</p>","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142925979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Renan Orellana-Walden Ph.D. , Manuel E. Cortés Ph.D.
{"title":"A nonhormonal target for endometriosis to explore","authors":"Renan Orellana-Walden Ph.D. , Manuel E. Cortés Ph.D.","doi":"10.1016/j.fertnstert.2024.08.352","DOIUrl":"10.1016/j.fertnstert.2024.08.352","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 1","pages":"Page 197"},"PeriodicalIF":6.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amelie Stenqvist M.D., Ph.D. , Mona Bungum Ph.D. , Anja Bisgaard Pinborg D.M.Sci. , Jeanette Bogstad M.D. , Anne Lis Englund D.M.Sci. , Marie Louise Grøndahl D.M.Sci. , Anne Zedeler Ph.D. , Stefan R. Hansson M.D., Ph.D. , Aleksander Giwercman M.D., Ph.D.
{"title":"High sperm deoxyribonucleic acid fragmentation index is associated with an increased risk of preeclampsia following assisted reproduction treatment","authors":"Amelie Stenqvist M.D., Ph.D. , Mona Bungum Ph.D. , Anja Bisgaard Pinborg D.M.Sci. , Jeanette Bogstad M.D. , Anne Lis Englund D.M.Sci. , Marie Louise Grøndahl D.M.Sci. , Anne Zedeler Ph.D. , Stefan R. Hansson M.D., Ph.D. , Aleksander Giwercman M.D., Ph.D.","doi":"10.1016/j.fertnstert.2024.08.316","DOIUrl":"10.1016/j.fertnstert.2024.08.316","url":null,"abstract":"<div><h3>Objective</h3><div>To study the association between sperm deoxyribonucleic acid fragmentation index (DFI) and the odds of preeclampsia and other adverse perinatal outcomes after in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) treatment.</div></div><div><h3>Design</h3><div>A prospective cohort study including infertile couples undergoing conventional IVF or ICSI treatment and their children. Data regarding preeclampsia and perinatal outcomes were derived from the Swedish National Birth Register.</div></div><div><h3>Patient(s)</h3><div>A total of 1,594 infertile couples undergoing IVF or ICSI treatment and their 1,660 children conceived by assisted reproduction.</div></div><div><h3>Exposure</h3><div>Sperm DFI measured by Sperm Chromatin Structure Assay.</div></div><div><h3>Main Outcome Measure(s)</h3><div>The primary outcome was preeclampsia. The secondary outcomes were preterm birth (PTB), low birth weight, low Apgar score, and small for gestational age.</div></div><div><h3>Result(s)</h3><div>With a DFI level of <20% as a reference, the odds ratio (OR) of preeclampsia statistically significantly increased in the group with a DFI level of ≥20% when IVF was used as the fertilization method (OR, 2.2; 95% confidence interval, 1.1–4.4). Already at the DFI levels of ≥10%, in IVF pregnancies, the OR of preeclampsia increased in a dose-response manner, from a prevalence of 3.1% in the reference group to >10% among those with a DFI level of ≥30%. The DFI was not associated with the OR of preeclampsia in the ICSI group. In the entire cohort, a DFI level of ≥20% was associated with an increased OR of PTB (OR, 1.4; 95% confidence interval, 1.0–2.0).</div></div><div><h3>Conclusion(s)</h3><div>High DFI level was associated with increased odds of PTB and, in IVF pregnancies, also increased odds of preeclampsia.</div></div><div><div>Un alto índice de fragmentación del ácido desoxirribonucleico espermático se asocia con un mayor riesgo de preeclampsia después de un tratamiento de reproducción asistida.</div></div><div><h3>Objetivo</h3><div>Estudiar la asociación entre el índice de fragmentación del ácido desoxirribonucleico (DFI) de los espermatozoides y las probabilidades de preeclampsia y otros resultados perinatales adversos después de un tratamiento de Fertilización In Vitro (FIV) e Inyección Intra Citoplasmática de Espermatozoides (ICSI).</div></div><div><h3>Diseño</h3><div>Estudio de cohorte prospectivo incluyendo parejas infértiles sometidas a un tratamiento convencional de FIV o ICSI y sus hijos. Los datos sobre preeclampsia y resultados perinatales se obtuvieron del Registro Nacional de Nacimientos de Suecia.</div></div><div><h3>Entorno</h3><div>Clínica de fertilidad afiliada a la universidad.</div></div><div><h3>Paciente(s)</h3><div>Un total de 1594 parejas infértiles sometidas a tratamiento de FIV o ICSI y sus 1660 hijos concebidos por reproducción asistida.</div></div><div><h3>Intervención(es)</h3><div>DFI de esp","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 1","pages":"Pages 97-104"},"PeriodicalIF":6.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Preovulation body mass index and pregnancy after first frozen embryo transfer in patients with polycystic ovary syndrome and insulin resistance","authors":"Hao Liang M.D., Ning Li M.D., Rong Li M.D.","doi":"10.1016/j.fertnstert.2024.08.328","DOIUrl":"10.1016/j.fertnstert.2024.08.328","url":null,"abstract":"<div><h3>Objective</h3><div>To examine the association between preovulation body mass index and pregnancy outcomes after frozen embryo transfer in patients with polycystic ovary syndrome with insulin resistance.</div></div><div><h3>Design</h3><div>This was a single-center, retrospective cohort study.</div></div><div><h3>Patient(s)</h3><div>Women with infertility, diagnosed with polycystic ovary syndrome and insulin resistance, and treated at the Reproductive Medicine Center, Second People’s Hospital of Nanning, China, between January 2020 and August 2023, were included.</div></div><div><h3>Exposure</h3><div>Patients were divided into four groups according to their body mass index (BMI): slim (<18.5 kg/m<sup>2</sup>), normal (18.5≤ BMI <24 kg/m<sup>2</sup>), overweight (24≤ BMI <28 kg/m<sup>2</sup>), or obese (≥28 kg/m<sup>2</sup>).</div></div><div><h3>Main Outcome Measure(s)</h3><div>The main pregnancy outcomes included rates of embryo implantation, biochemical pregnancy, clinical pregnancy, and ongoing pregnancy.</div></div><div><h3>Result(s)</h3><div>In total, 282 eligible patients were included. A linear association was observed between the BMI and clinical pregnancy outcomes of the first frozen embryo transfer. After accounting for all potential variables, each 1 kg/m<sup>2</sup> increase in BMI was linked to a 2% decrease in the embryo implantation rate, 11% decrease in the frequency of biochemical pregnancy, and 9% decrease in the both clinical and ongoing pregnancy rates.</div></div><div><h3>Conclusion(s)</h3><div>In patients with polycystic ovary syndrome and insulin resistance, a higher BMI was associated with lower rates of embryo implantation, biochemical pregnancy, clinical pregnancy, and ongoing pregnancy.</div></div><div><div>Indice de masa corporal preovulatorio y embarazo tras la primera transferencia transferencia de embriones congelados ovario poliquístico y resistencia a la insulina</div></div><div><h3>Objetivo</h3><div>Examinar la asociación entre el índice de masa corporal preovulatorio y los resultados del embarazo tras la transferencia de embriones congelados en pacientes con síndrome de ovario poliquístico con resistencia a la insulina.</div></div><div><h3>Diseño</h3><div>Se trata de un estudio de cohortes retrospectivo de un solo centro.</div></div><div><h3>Entorno</h3><div>No aplicable.</div></div><div><h3>Paciente(s)</h3><div>Mujeres con infertilidad, diagnosticadas con síndrome de ovario poliquístico y resistencia a la insulina, y tratadas en el Centro de Medicina Reproductiva del Segundo Hospital Popular de Nanning, China, entre enero de 2020 y agosto de 2023.</div></div><div><h3>Intervención(es)</h3><div>Las pacientes se dividieron en cuatro grupos según su índice de masa corporal (IMC): delgada (<18,5 kg/m2), normal (18,5IMC <24 kg/m2), sobrepeso (24% IMC <28 kg/m2), u obesidad (R28 kg/m2).</div></div><div><h3>Medida(s) principal(es) de desenlace</h3><div>Los principales desenlaces de embarazo incl","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 1","pages":"Pages 105-114"},"PeriodicalIF":6.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141999680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endometriosis and risk of adverse pregnancy outcomes: a retrospective multicenter cohort study","authors":"Françoise Vendittelli M.D., Ph.D , Chloé Barasinski Ph.D , Olivier Rivière , Nicolas Bourdel M.D., Ph.D. , Xavier Fritel M.D., Ph.D.","doi":"10.1016/j.fertnstert.2024.07.037","DOIUrl":"10.1016/j.fertnstert.2024.07.037","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate first, the association between endometriosis and preterm birth; second, the associations between endometriosis and preeclampsia, placenta previa, postpartum hemorrhage, stillbirth, and small-for-gestational-age infants (assessed by birthweight); and third, the risk of these adverse pregnancy outcomes with and without the use of medically assisted reproduction.</div></div><div><h3>Design</h3><div>Multicenter retrospective cohort study.</div></div><div><h3>Patients</h3><div>Deliveries by 368,935 women (377,338 infants) from 1999 through 2016.</div></div><div><h3>Exposure</h3><div>Endometriosis, defined as a single disease entity (endometriosis and/or ademyosis)</div></div><div><h3>Main Outcomes Measures</h3><div>The main outcome was the preterm birth rate (both <37 and <33 weeks). The secondary outcomes were rates of preeclampsia, placenta previa, postpartum hemorrhage, stillbirth, and small-for-gestational-age neonates.</div></div><div><h3>Results</h3><div>Women in the endometriosis group had more frequent histories of infertility before the included pregnancy (34.7 vs. 5.0%), more hospitalizations during the pregnancy (27.4 vs. 19.8%), and more planned cesarean sections (14.0 vs. 8.7); they more often were nulliparous (51.7 vs. 43.4%). The prevalence of preterm birth at <37 weeks was 11.1% in the endometriosis group and 7.7% in the unexposed group, and for <33 weeks, it was 3.1% and 2.2%, respectively. The adjusted relative risk for confounding factors was higher in the endometriosis than the unexposed group for preterm delivery <37 weeks (1.40, 95% confidence interval, 1.18–1.67) or <33 weeks (1.53, 95% confidence interval, 1.08–2.16). For the secondary outcomes, the adjusted risk ratios for preeclampsia, placenta previa, postpartum hemorrhage, and small-for-gestational-age status of <10th and <5th percentiles were higher in the endometriosis group. The adjusted risk ratios for stillbirth and small-for-gestational-age status of <3rd percentile did not differ between the two groups, and those after stratification by medically assisted reproduction for preterm birth at <37 and <33 weeks did not differ statistically significantly between them, for the secondary outcomes, only the risk of placenta previa was higher in the medically assisted reproduction and non–medically assisted reproduction subgroups.</div></div><div><h3>Conclusion</h3><div>Pregnant women with endometriosis had higher risks of preterm birth and other poor pregnancy outcomes than women without endometriosis.</div></div><div><div>Endometriosis y riesgo de resultados adversos en el embarazo: un estudio de cohorte multicéntrico retrospectivo</div></div><div><h3>Objetivo</h3><div>Investigar, en primer lugar, la asociación entre la endometriosis y el parto prematuro; en segundo lugar, las asociaciones entre la endometriosis y la pre-eclampsia, la placenta previa, la hemorragia posparto, la muerte fetal y los rec","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 1","pages":"Pages 137-147"},"PeriodicalIF":6.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141874589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Madeline G. Kroeger M.D. , Jessica D. Kresowik M.D.
{"title":"Should we rescue clubbed fallopian tubes? A commentary on “Laparoscopic salpingostomy for two types of hydrosalpinx: a step-by-step video tutorial”","authors":"Madeline G. Kroeger M.D. , Jessica D. Kresowik M.D.","doi":"10.1016/j.fertnstert.2024.10.039","DOIUrl":"10.1016/j.fertnstert.2024.10.039","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 1","pages":"Page 74"},"PeriodicalIF":6.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}