Fertility and sterility最新文献

{"title":"Pulsatile gonadotropin-releasing hormone therapy: does one size fit all?","authors":"Luce A. Kassi M.D., Jennifer L. Eaton M.D., M.S.C.I.","doi":"10.1016/j.fertnstert.2024.11.026","DOIUrl":"10.1016/j.fertnstert.2024.11.026","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 2","pages":"Pages 243-244"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142762993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hormone-free vs. follicle-stimulating hormone–primed infertility treatment of women with polycystic ovary syndrome using biphasic in vitro maturation: a randomized controlled trial","authors":"Lan N. Vuong M.D., Ph.D. , Vu N.A. Ho M.D. , Anh H. Le MS.c. , Nam T. Nguyen M.D. , Toan D. Pham MS.c. , Minh H.N. Nguyen M.Sc. , Ho L. Le M.D. , Tien K. Le M.D. , Anh N. Ha M.D. , Xuyen T.H. Le M.D. , Huy H. Pham M.Sc. , Cam T. Tran MS.c. , Bao G. Huynh Ph.D. , Johan E.J. Smitz M.D., Ph.D. , Robert B. Gilchrist D.Sc.Agr. , Tuong M. Ho M.D.","doi":"10.1016/j.fertnstert.2024.09.010","DOIUrl":"10.1016/j.fertnstert.2024.09.010","url":null,"abstract":"<div><h3>Objective</h3><div>To compare oocyte maturation rates and pregnancy outcomes in women with polycystic ovary syndrome (PCOS) undergoing biphasic in vitro maturation (capacitation in vitro maturation [CAPA-IVM]) with vs. without follicle-stimulating hormone (FSH) priming.</div></div><div><h3>Design</h3><div>Randomized, controlled, assessor-blinded trial.</div></div><div><h3>Subjects</h3><div>Women aged 18–37 years with PCOS and an indication for CAPA-IVM.</div></div><div><h3>Intervention(s)</h3><div>Participants were randomized (1:1) to undergo CAPA-IVM with or without FSH priming. The FSH priming group had 2 days of FSH injections before oocyte pickup; no FSH was given in the non-FSH group. After CAPA-IVM, day-5 embryos were vitrified for transfer in a subsequent cycle.</div></div><div><h3>Main Outcome Measure(s)</h3><div>The primary endpoint was number of matured oocytes. Secondary outcomes included rates of live birth, implantation, clinical pregnancy, ongoing pregnancy, pregnancy complications, obstetric and perinatal complications, and neonatal complications.</div></div><div><h3>Result(s)</h3><div>The number (interquartile range) of matured oocytes did not differ significantly in the non-FSH vs. FSH group (13 [9–18] vs. 14 [7–18]; absolute difference –1 [95% confidence interval –5 to 4]); other oocyte and embryology outcomes did not differ between groups. Rates of ongoing pregnancy and live birth were 38.3% in the non-FSH group and 31.7% in the FSH group (risk ratio for both outcomes: 1.21, 95% confidence interval 0.74–1.98). Maternal complications were infrequent and occurred at a similar rate in the two groups; there were no preterm deliveries before 32 weeks gestation.</div></div><div><h3>Conclusion(s)</h3><div>These findings open the possibility of a new, hormone-free approach to infertility treatment of women with PCOS.</div></div><div><h3>Clinical Trail Registration Number</h3><div>NCT05600972.</div></div><div><div>Tratamiento de infertilidad sin uso de hormonas vs. preparado de hormona folículo estimulante en mujeres con síndrome de ovario poliquístico sometidas a maduración in vitro bifásica: un ensayo controlado aleatorizado</div></div><div><h3>Objetivo</h3><div>Comparar las tasas de maduración de ovocitos y los resultados del embarazo en mujeres con síndrome de ovario poliquístico (SOP) sometidas a maduración in vitro bifásica (maduración in vitro de capacitación [CAPA-IVM]) con y sin preparado de hormona folículo estimulante (FSH).</div></div><div><h3>Diseño</h3><div>Ensayo aleatorizado, controlado, con evaluador ciego.</div></div><div><h3>Contexto</h3><div>Hospital privado.</div></div><div><h3>Pacientes</h3><div>Mujeres de 18 a 37 años con SOP e indicación de CAPA-IVM.</div></div><div><h3>Intervención</h3><div>Las participantes fueron asignadas al azar (1:1) para someterse a CAPA-IVM con o sin preparado de FSH. El grupo con FSH recibió 2 días de inyecciones de FSH antes de la recolección de ovocitos; no se administró FSH e","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 2","pages":"Pages 253-261"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the hormonal impact of high-fat diets: gaps in gonadotropin and adrenocorticotropic hormone responses and the need for detailed fat composition analysis","authors":"Meihua Zheng Ph.D. , Juan Tang Ph.D.","doi":"10.1016/j.fertnstert.2024.09.037","DOIUrl":"10.1016/j.fertnstert.2024.09.037","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 2","pages":"Page 377"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generation of epithelial-stromal assembloids as an advanced in vitro model of impaired adenomyosis-related endometrial receptivity","authors":"Christina Anna Stratopoulou Ph.D. , Margherita Rossi M.S. , Chloé Beaussart M.D. , Margherita Zipponi M.S. , Alessandra Camboni M.D., Ph.D. , Jacques Donnez M.D., Ph.D. , Marie-Madeleine Dolmans M.D., Ph.D.","doi":"10.1016/j.fertnstert.2024.08.339","DOIUrl":"10.1016/j.fertnstert.2024.08.339","url":null,"abstract":"<div><h3>Objective</h3><div>To create a novel, more advanced in vitro model of human endometrium, using so-called assembloids, looking to explore endometrial receptivity in adenomyosis.</div></div><div><h3>Design</h3><div>Evaluation of assembloid responsiveness to hormonal stimulation by immunohistochemistry, enzyme-linked immunosorbent assay, and scanning electron microscopy.</div></div><div><h3>Subjects</h3><div>Twelve women, six of whom were affected by adenomyosis.</div></div><div><h3>Exposure</h3><div>Organoids (in the form of glandular fragments) and stromal fibroblasts were collected from endometrial biopsies. The two populations were combined inside an extracellular matrix to create 3D assembloids, which were then exposed to hormonal stimulation (β-estradiol for 48 hours, followed by β-estradiol/progesterone/cyclic adenosine monophosphate for 72 hours) to mimic the window of implantation.</div></div><div><h3>Main Outcome Measure(s)</h3><div>Glycodelin, leukemia inhibitory factor (LIF), and homeobox A10 (HOXA10) expression, prolactin secretion, and pinopode development.</div></div><div><h3>Result(s)</h3><div>Endometrial organoids and stromal cells were successfully isolated from women with and without adenomyosis and combined to generate the assembloid model. On stimulation, assembloids from both groups acquired a more secretory phase-like phenotype, as demonstrated by histology, and were shown to be positive for glycodelin, LIF, and HOXA10 by immunohistochemistry. Adenomyotic assembloids expressed significantly lower levels of LIF and HOXA10 within the stromal compartment after stimulation than did healthy assembloids in the same condition. Enzyme-linked immunosorbent assay revealed prolactin secretion in vitro, showing an upward trend in hormonally treated assembloids from both healthy and affected women. By scanning electron microscopy, fully formed pinopodes were discerned on the epithelial surface of healthy assembloids after stimulation, but they were absent in case of adenomyosis.</div></div><div><h3>Conclusion(s)</h3><div>Primary assembloids can be generated from endometrial biopsies from both healthy subjects and women affected by adenomyosis. These assembloids are amenable to hormonal stimulation and mimic secretory phase-specific characteristics of endometrial tissue in vivo, including glycodelin, LIF, and HOXA10 expression, and pinopode formation. Assembloids from adenomyosis appear to be less sensitive to hormonal treatment, showing reduced expression of LIF and HOXA10 in the stromal compartment and failing to form pinopodes. All in all, endometrial assembloids may serve as an advanced preclinical model of adenomyosis-related impaired endometrial receptivity, opening up new horizons in understanding and treating the condition.</div></div><div><h3>Título</h3><div>Generación de asembloides epiteliales-estromales como modelo avanzado in vitro de receptividad endometrial alterada relacionada con adenomiosis</div></div><div><h3>Obj","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 2","pages":"Pages 350-360"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142092587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polycystic ovarian morphology: the number of chocolate chips is more important than the size of the cookie","authors":"Alexander M. Quaas M.D., Ph.D.","doi":"10.1016/j.fertnstert.2024.11.028","DOIUrl":"10.1016/j.fertnstert.2024.11.028","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 2","pages":"Pages 247-248"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should physicians be facilitating gestational carrier arrangements in the absence of medical indication?","authors":"Brian Levine M.D., M.S. , Alexis L. Cirel Esq. , Kate D. Schoyer M.D. , Arthur R. Derse M.D., J.D. , Robert T. Rydze M.D. , Eve C. Feinberg M.D.","doi":"10.1016/j.fertnstert.2024.11.013","DOIUrl":"10.1016/j.fertnstert.2024.11.013","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 2","pages":"Pages 201-207"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Target trial emulation of preconception serum vitamin D status on fertility outcomes: a couples-based approach","authors":"Julia D. DiTosto M.S. , Ellen C. Caniglia Sc,.D. , Stefanie N. Hinkle Ph.D. , Naria Sealy B.A. , Enrique F. Schisterman Ph.D. , Erica Johnstone M.D. , Pauline Mendola Ph.D. , James Mills M.D. , Jim Hotaling M.D. , Ginny Ryan M.D. , Sunni L. Mumford Ph.D.","doi":"10.1016/j.fertnstert.2024.08.332","DOIUrl":"10.1016/j.fertnstert.2024.08.332","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate associations between preconception 25-hydroxyvitamin D (25(OH)D) levels and biomarkers in female and male partners on live birth (LB), pregnancy loss, and semen quality.</div></div><div><h3>Design</h3><div>Secondary analysis using the folic acid and zinc supplementation trial of couples seeking infertility treatment at four US centers (2013–2017). A target trial emulation framework was applied to estimate associations. Couples were observed for 9 months or through pregnancy.</div></div><div><h3>Subjects</h3><div>Couples seeking infertility treatment.</div></div><div><h3>Intervention(s)</h3><div>Preconception concentrations of 25(OH)D (primary) and associated biomarkers: vitamin D binding protein, calcium, free vitamin D, bioavailable vitamin D.</div></div><div><h3>Main Outcome Measure(s)</h3><div>Live birth and pregnancy loss were ascertained via self-report and medical records. Semen quality was ascertained 6 months after enrollment. Log-binomial regression estimated risk ratios and 95% confidence intervals (CIs). Individual and joint models and effect measure modification by preconception body mass index were considered.</div></div><div><h3>Result(s)</h3><div>Among 2,370 couples, 19.5% of females and 29.9% of males were 25(OH)D deficient. Females with sufficient status had a 28%-higher likelihood of LB than deficient females (95% CI, 1.05–1.56). Female and male 25(OH)D status were associated with LB among those with normal body mass index (sufficient vs. deficient: female adjusted risk ratio [aRR], 1.39; 95% CI, 1.00–1.99; male aRR, 1.51; 95% CI, 1.01–2.25) and among obese female partners (sufficient vs. deficient: aRR, 1.33; 95% CI, 0.95–1.85). Couples whose both partners had higher 25(OH)D status had increased likelihood of LB (both not deficient vs. both deficient aRR, 1.26; 95% CI, 1.00–1.58). No associations were observed with pregnancy loss or semen quality. Similar results were found for all biomarkers except calcium.</div></div><div><h3>Conclusion(s)</h3><div>Preconception vitamin D status and bioavailability impact fertility among couples seeking infertility therapy, likely unrelated to semen quality. Body mass index stratified analyses demonstrated heterogeneous associations.</div></div><div><h3>Clinical Trial Registration Number</h3><div>NCT01857310.</div></div><div><div>Emulación de ensayos clínicos sobre el estado de vitamina D en suero preconcepcional y sus efectos sobre los resultados en la fertilidad: un enfoque basado en parejas.</div></div><div><h3>Objetivo</h3><div>Evaluar la asociación entre los niveles preconcepcionales de 25-hidroxivitamina D (25(OH)D) y los biomarcadores en mujeres y sus parejas varones con respecto al nacido vivo (LB), a la pérdida gestacional y a la calidad del semen.</div></div><div><h3>Diseño</h3><div>Análisis secundario del ensayo de suplementación con ácido fólico y zinc en parejas que buscaban tratamiento de infertilidad en cuatro centros de EE.UU. (2013-2017","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 2","pages":"Pages 300-312"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Criteria for the fellowship match: are we using the right parameters?","authors":"Ruben Alvero M.D. , Ruth B. Lathi M.D.","doi":"10.1016/j.fertnstert.2024.12.001","DOIUrl":"10.1016/j.fertnstert.2024.12.001","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 2","pages":"Pages 249-250"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estrogen-progestins and endometriosis-associated depression: of causation, bias, and confounding.","authors":"Noemi Salmeri, Sonia Cipriani, Paolo Vercellini","doi":"10.1016/j.fertnstert.2025.01.026","DOIUrl":"10.1016/j.fertnstert.2025.01.026","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to monitor the efficacy of ovarian stimulation for assisted reproductive technology?","authors":"Paul Pirtea, Jean Marc Ayoubi, Baris Ata","doi":"10.1016/j.fertnstert.2025.01.027","DOIUrl":"10.1016/j.fertnstert.2025.01.027","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}