Fertility and sterility最新文献

{"title":"From breast cancer to fertility outcomes: increasing understanding of urgent fertility preservation","authors":"Shunshun Cao M.Sc. , Yangyang Hu M.Sc.","doi":"10.1016/j.fertnstert.2024.09.026","DOIUrl":"10.1016/j.fertnstert.2024.09.026","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 2","pages":"Page 375"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomized, controlled, proof-of-concept trial of gefapixant for endometriosis-related pain","authors":"Felipe Arbelaez M.D. , Hee-Koung Joeng Ph.D. , Azher Hussain Ph.D. , Sheila Sunga Ph.D. , Yanfen Guan M.S. , Akshita Chawla Ph.D. , Francisco Carmona M.D. , Christopher Lines Ph.D. , Geraldine Mendizabal M.D.","doi":"10.1016/j.fertnstert.2024.09.013","DOIUrl":"10.1016/j.fertnstert.2024.09.013","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the P2X3 receptor antagonist, gefapixant, for treating moderate-to-severe endometriosis-related pain.</div></div><div><h3>Design</h3><div>Randomized, double-blind, phase 2, and proof-of-concept trial.</div></div><div><h3>Subjects</h3><div>Premenopausal women age 18–49 years with moderate-to-severe endometriosis-related pain who were not using hormonal treatment.</div></div><div><h3>Intervention(s)</h3><div>Gefapixant (45-mg twice daily) or placebo over two menstrual cycles.</div></div><div><h3>Main outcome measure(s)</h3><div>Participants rated peak pelvic pain severity daily on a 0 (no pain) – 10 (extremely severe pain) scale. The primary endpoint was change from baseline in average daily peak pelvic pain severity during treatment cycle 2.</div></div><div><h3>Result(s)</h3><div>All 187 participants randomized (gefapixant, N = 94; placebo, N = 93) took ≥1 dose of investigational treatment and all but six in each treatment group completed the trial. The model-based least-squares mean reduction from baseline in average daily peak pelvic pain severity during treatment cycle 2 was –2.2 for gefapixant and –1.7 for placebo (difference, –0.5; 95% confidence interval, –1.01 to 0.03). In secondary analyses, the difference between gefapixant and placebo in peak pelvic pain severity reduction from baseline on menstrual days was –0.6 (95% confidence interval, –1.18 to –0.06) and –0.5 (95% confidence interval, –1.04 to 0.03) on nonmenstrual days. Taste-related adverse events were reported in 31.9% of participants for gefapixant vs. 4.3% for placebo. Pharmacokinetic assessments at months 1 and 2 clinic visits indicated that of the 94 participants in the gefapixant group, 39 had detectable levels of gefapixant in the blood for both assessments although 38 had no detectable levels for ≥1 assessment.</div></div><div><h3>Conclusion(s)</h3><div>Gefapixant (45-mg twice daily) was not shown to be superior to placebo in reducing endometriosis-related pain, although the results directionally favored gefapixant. This trial result should be considered inconclusive given possible issues with treatment compliance.</div></div><div><h3>Clinical Trial Registration Number</h3><div>NCT03654326.</div></div><div><div>Ensayo Aleatorizado, controlado, prueba de concepto de gefapixant para el dolor relacionado con la endometriosis</div></div><div><h3>Objetivo</h3><div>Evaluar el receptor antagonista del P2X3, gefapixant, para el tratamiento del dolor moderado a severo relacionado con la endometriosis.</div></div><div><h3>Diseño</h3><div>ensayo aleatorizado, doble ciego, de fase 2 y de prueba de concepto.</div></div><div><h3>Ámbito</h3><div>Pacientes ambulatorios en hospitales, centros médicos o sitios de investigación clínica.</div></div><div><h3>Paciente(s)</h3><div>Mujeres premenopáusicas de 18 a 49 años con dolor relacionado con la endometriosis de moderado a severo que no estaban usando tratamiento hormonal.</div></div><div><h3>Intervenció","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 2","pages":"Pages 280-288"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The additional value of ultrasound markers in the diagnosis of polycystic ovary syndrome","authors":"Kim van der Ham M.D. , Federica Barbagallo M.D. , Emiliya van Schilfgaarde B.Sc. , Marla E. Lujan Ph.D. , Joop S.E. Laven Ph.D. , Yvonne V. Louwers Ph.D.","doi":"10.1016/j.fertnstert.2024.08.342","DOIUrl":"10.1016/j.fertnstert.2024.08.342","url":null,"abstract":"<div><h3>Objective</h3><div>To study the value of current definitions for follicle number per ovary and ovarian volume in the diagnosis of polycystic ovary syndrome (PCOS).</div></div><div><h3>Design</h3><div>Cross-sectional study.</div></div><div><h3>Subjects</h3><div>Women diagnosed with PCOS after standardized screening were eligible for inclusion in the PCOS group. Women without PCOS who underwent the same screening, had regular menstrual cycles, normal hormonal values, and no other endocrine pathology were eligible for inclusion.</div></div><div><h3>Exposure</h3><div>Not applicable.</div></div><div><h3>Main Outcome Measure(s)</h3><div>Follicle number per ovary and ovarian volume in women with PCOS, stratified by age. Linear regression models to investigate the influence of body mass index (BMI) on follicle number per ovary and ovarian volume. Differences in follicle number per ovary and ovarian volume between the PCOS phenotypes and the additional value of ovarian volume compared with follicle number per ovary.</div></div><div><h3>Result(s)</h3><div>A total of 2,492 women (16–50 years) with PCOS and 152 women without PCOS were included. Most women with PCOS up to age of 35 exhibit a follicle number per ovary ≥20 (87.8%–100%) (using an ultrasound transducer ≥8 MHz) or ≥12 (95.1%–98.6%) (using a transducer <8 MHz), followed by a decline in follicle number per ovary >35 years. Median ovarian volume was below the 10 mL cutoff in every age group, for both ultrasound transducers. Follicle number per ovary and ovarian volume were higher in women with PCOS compared with women without PCOS in every age category. In our cohort, 13/2,297 women with PCOS (0.6%) would not have received the diagnosis if ovarian volume was not considered a marker for polycystic ovarian morphology. For both ultrasound transducers, women with phenotype A (ovulatory dysfunction + hyperandrogenism + polycystic ovarian morphology) exhibited the highest follicle number per ovary and ovarian volume, followed by phenotype D (ovulatory dysfunction + polycystic ovarian morphology), then phenotype C (hyperandrogenism + polycystic ovarian morphology), and then phenotype B (ovulatory dysfunction + hyperandrogenism). No clinically significant correlation between BMI and follicle number per ovary or ovarian volume was observed.</div></div><div><h3>Conclusion(s)</h3><div>Criteria to define follicle number per ovary should be established per age category, as follicle number per ovary decreases with age. Ovarian volume shows a less clear decline with age and has a lower discriminative power, and therefore could be excluded from the diagnostic criteria. Follicle number per ovary does not need to be stratified by BMI.</div></div><div><div>El valor adicional de los marcadores ecográficos en el diagnóstico del síndrome de ovario poliquístico</div></div><div><h3>Objetivo</h3><div>Estudiar el valor de las definiciones actuales del número de folículos por ovario y el volumen ovárico en el di","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 2","pages":"Pages 342-349"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A long road ahead: medical management for endometriosis-related pain. Just keep looking","authors":"Jose Carugno M.D. , Amira Quevedo M.D. , Nash S. Moawad M.D., M.S.","doi":"10.1016/j.fertnstert.2024.11.015","DOIUrl":"10.1016/j.fertnstert.2024.11.015","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 2","pages":"Pages 237-238"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the burden of hypoestrogenism","authors":"Seifeldin Sadek M.D. , Amanda M. Ryan M.D. , Amr S. El Haraki M.D.","doi":"10.1016/j.fertnstert.2024.11.023","DOIUrl":"10.1016/j.fertnstert.2024.11.023","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 2","pages":"Pages 241-242"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highlighting the importance of identity formation and the implications for psychological well-being among donor conceived individuals","authors":"Mary P. Riddle Ph.D.","doi":"10.1016/j.fertnstert.2024.11.027","DOIUrl":"10.1016/j.fertnstert.2024.11.027","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 2","pages":"Pages 245-246"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply of the authors","authors":"Scott M. Nelson Ph.D. , Karema Alrashid Ph.D. , Martin Shaw Ph.D. , Richard A. Anderson Ph.D.","doi":"10.1016/j.fertnstert.2024.09.019","DOIUrl":"10.1016/j.fertnstert.2024.09.019","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 2","pages":"Page 374"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increase in open-identity sperm donation in the United States since 1996","authors":"Austin Valido B.A. , Victoria Harbour M.S. , Joanna E. Scheib Ph.D.","doi":"10.1016/j.fertnstert.2024.09.012","DOIUrl":"10.1016/j.fertnstert.2024.09.012","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 2","pages":"Pages 361-363"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply of the authors: evaluating the hormonal impact of high-fat diets: gaps in gonadotropin and adrenocorticotropic hormone responses and the need for detailed fat composition analysis","authors":"Andrew P. Bradford Ph.D., Thy Nguyen B.A., Katherine Kuhn M.S., Nanette Santoro M.D.","doi":"10.1016/j.fertnstert.2024.10.005","DOIUrl":"10.1016/j.fertnstert.2024.10.005","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 2","pages":"Page 378"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Embryofetoscopy followed by hysteroscopic evacuation of a first trimester missed abortion in a woman with septate uterus","authors":"Maria Chiara De Angelis M.D. , Danilo Borrelli M.D. , Brunella Zizolfi M.D. , Alessandra Gallo M.D. , Sardo Attilio Di Spiezio M.D., Ph.D. , Jose Carugno M.D.","doi":"10.1016/j.fertnstert.2024.10.050","DOIUrl":"10.1016/j.fertnstert.2024.10.050","url":null,"abstract":"<div><h3>Objective</h3><div>To describe the technique of embryofetoscopy performed with 5Fr instruments with targeted evacuation of the gestational sac followed by a visual dilatation and curettage (D&C) using the hysteroscopic tissue removal system for the management of first trimester missed abortion in a patient with uterine septum.</div></div><div><h3>Design</h3><div>Video case-report.</div></div><div><h3>Subjects</h3><div>A 32-year-old nulliparous (G3P0020) woman with septate uterus and a 7-week missed abortion. Written informed consent was obtained from the patient.</div></div><div><h3>Exposure</h3><div>Transvaginal pelvic ultrasound revealed a 7-week missed abortion. A 3D-ultrasound confirmed the presence of a partial uterine septum. Operative hysteroscopy under spinal anesthesia was performed using a vaginoscopic approach. A partial septum was observed, and a dysmorphic gestational sac was visualized in the left hemicavity.A small incision was made in the amniotic sac using a 5Fr-bipolar electrode allowing direct visualization of the embryo. The entire embryo was removed, and selective biopsies of the chorionic villi using the hysteroscopic “grasp biopsy” technique were obtained. The residual gestational sac was removed using a 6.25 mm tissue retrieval system. No cervical dilation was required.The patient was discharged on the same day of the procedure. No intraoperative bleeding was encountered. The overall operation time was 21 minutes. A postprocedure ultrasound confirmed the presence of an empty cavity. It was determined that further evaluation of the septum was needed before proceeding with hysteroscopic metroplasty.</div></div><div><h3>Main Outcome Measure(s)</h3><div>Step-by-step demonstration of the technique and some tips and tricks for bleeding management.</div></div><div><h3>Result(s)</h3><div>Complete evacuation of the uterine cavity under direct visualization.</div></div><div><h3>Conclusion(s)</h3><div>Embryofetoscopy with miniaturized instruments allows selective targeting of trophoblastic and fetal tissues, avoiding the risk of maternal tissue contamination of the specimen. As reported in the literature, the visual D&C using tissue retrieval system could be a safe and innovative alternative for the treatment of early pregnancy loss. Compared with the use of hysteroscopic resection, tissue removal devices offer the advantage of not requiring cervical dilation and do not involve the use of electrosurgery, thus reducing damage to the uterine cavity. The combination of embryofetoscopy with visual D&C offers several advantages, especially in patients with congenital uterine anomalies, in which performing a blind D&C has a higher risk of complications.</div></div><div><div>Embrioscopia fetal seguida de evacuación por histeroscópica de un aborto retenido en el primer trimestre en una mujer con útero septado.</div></div><div><h3>Objetivo</h3><div>Describir la técnica de embrioscopia fetal realizada con instrumentos ","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 2","pages":"Pages 367-369"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}