Fertility and sterility最新文献

{"title":"Tips and Tricks for Robotic Management of Diffuse Adenomyosis.","authors":"Gaby Moawad, Anis Feki, Jean Marc Ayoubi, Antoine Naem, Youssef Youssef","doi":"10.1016/j.fertnstert.2024.11.024","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2024.11.024","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the burden of hypoestrogenism.","authors":"Seifeldin Sadek, Amanda M Ryan, Amr S El Haraki","doi":"10.1016/j.fertnstert.2024.11.023","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2024.11.023","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"10.1016/j.fertnstert.2024.10.044","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2024.10.044","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142727064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimüllerian hormone and antral follicle count thresholds for hyperresponse risk assessment in in vitro fertilization: a Hyperresponse Risk Assessment consensus study.","authors":"Alyssa Hochberg, Sandro C Esteves, Hakan Yarali, Lan N Vuong, Michael H Dahan","doi":"10.1016/j.fertnstert.2024.11.021","DOIUrl":"10.1016/j.fertnstert.2024.11.021","url":null,"abstract":"<p><strong>Objective: </strong>To determine the serum antimüllerian hormone (AMH) and antral follicle count (AFC) thresholds indicating an increased risk of hyperresponse to ovarian stimulation (OS) during in vitro fertilization, as defined by the Hyperresponse Risk Assessment (HERA) Delphi Consensus.</p><p><strong>Design: </strong>A retrospective multicenter cohort study.</p><p><strong>Setting: </strong>Three fertility centers.</p><p><strong>Patient(s): </strong>Women with normal ovarian reserve markers according to the POSEIDON criteria (AMH level of ≥1.2 ng/mL and AFC of ≥5) undergoing their first in vitro fertilization/ intracytoplasmic sperm injection cycle with conventional OS (follicle-stimulating hormone [FSH] level of ≥150 IU/d) using the gonadotropin-releasing hormone antagonist protocol (2015-2017) were included.</p><p><strong>Intervention(s): </strong>Hyperresponse was defined as ≥15 retrieved oocytes, on the basis of the HERA definition, compared with non-HERA hyperresponders, defined as patients with ovarian reserve markers within the normal range per the POSEIDON criteria and with <15 oocytes retrieved.</p><p><strong>Main outcome measure(s): </strong>The primary outcome was the AMH and AFC threshold values, indicating an increased risk of a hyperresponse, using receiver operator characteristic curves. Outcomes were further stratified by patients' age (<35 and ≥35 years). Multivariable logistic regression explored factors associated with an HERA hyperresponse.</p><p><strong>Result(s): </strong>A total of 4,220 patients were included, of whom 2,132 (50.5%) were hyperresponders. Receiver operator characteristic curves revealed the following thresholds for a hyperresponse: AMH level of ≥4.38 ng/mL (area under the curve [AUC], 0.71) and AFC of ≥16 (AUC, 0.80) for the entire cohort; AMH level of ≥4.95 ng/mL (AUC, 0.68) and AFC of ≥18 (AUC, 0.76) for women aged <35 years (N = 3,056); and AMH level of ≥4.33 ng/mL (AUC, 0.77) and AFC of ≥15 (AUC, 0.86) for women aged ≥35 years (N = 1,164). Older women received higher median daily and total FSH doses than younger women. The AMH, AFC, female age, daily/total gonadotropin dose, type of gonadotropin, and trigger strategy were significant predictors for hyperresponse.</p><p><strong>Conclusion(s): </strong>The AMH and AFC values at and above these thresholds warrant increased caution when planning gonadotropin dosing, regimen, and trigger strategies before OS. These thresholds were lower in older women, potentially due to higher FSH dosing in this population.</p>","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reproductive outcome after fertility treatment in women with von Willebrand disease: a retrospective cohort study.","authors":"Lennert Haack, Bjarne Dasenbrook, Paula Steiner, Beate Krammer-Steiner, Michael Steiner, Johannes Stubert","doi":"10.1016/j.fertnstert.2024.11.020","DOIUrl":"10.1016/j.fertnstert.2024.11.020","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of ultrasound-based endometriosis staging system in anticipating complexity of laparoscopic surgery.","authors":"Mahbod Ebrahimi, Sholeh Naghdi, Fatemeh Davari-Tanha, Behnaz Moradi, Elham Feizabad, Kiana Majidi","doi":"10.1016/j.fertnstert.2024.11.018","DOIUrl":"10.1016/j.fertnstert.2024.11.018","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effectiveness of the preoperative ultrasound-based endometriosis staging system (UBESS) in anticipating the complexity of laparoscopic surgery for optimal patient counseling and treatment.</p><p><strong>Design: </strong>A prospective observational cohort study.</p><p><strong>Setting: </strong>A tertiary teaching hospital.</p><p><strong>Patient(s): </strong>A total of 157 women presenting with chronic pelvic pain and/or a history of endometriosis underwent laparoscopic surgery between June 2019 and May 2023.</p><p><strong>Intervention(s): </strong>Eligible women underwent transvaginal ultrasound before laparoscopic surgery.</p><p><strong>Main outcome measure(s): </strong>The UBESS staging was conducted based on ultrasound results. Subsequently, the necessary surgical skill levels were assessed, during the laparoscopic procedure, using the Royal Australian and New Zealand College of Obstetricians and Gynecologists/Australasian Gynecological Endoscopy and Surgery (RANZCOG/AGES) system. The study aimed to evaluate the correlation between the three UBESS stages and the six RANZCOG/AGES laparoscopic skill levels. The primary objective was how accurately the UBESS predicts the complexity of endometriosis laparoscopic surgery.</p><p><strong>Result(s): </strong>The UBESS staging system classified nine patients (5.9%) as UBESS I, 61 patients (40.1%) as UBESS II, and 82 patients (53.9%) as UBESS III. The accuracy, sensitivity, specificity, positive and negative predictive values, and positive and negative likelihood ratios of the UBESS I for anticipating RANZCOG/AGES levels 1/2 were: 99.3%, 90%, 100%, 100%, 99.3%, not applicable, and 0.1%. For UBESS II to anticipate RANZCOG/AGES levels 3/4 were 96.7%, 95.1%, 97.7%, 96.7%, 96.7%, 0.92, and 0.04, and for UBESS III to anticipate RANZCOG/AGES level 6 were 97.3%, 98.7%, 95.8%, 96.3%, 98.5%, 0.94, and 0.01, respectively. Ultrasound-based endometriosis staging system was highly accurate in anticipating the complexity of laparoscopic surgery based on RANZCOG/AGES laparoscopic skill levels, with an overall accuracy of 96.7% and a Cohen's kappa value of 0.94, which implies an approximately complete level of agreement. Considering the significant number of UBESS II and UBESS III patients and their high accuracy, sensitivity, and specificity, this staging system is an effective tool for predicting moderate-to-severe endometriosis.</p><p><strong>Conclusion(s): </strong>The study indicated that UBESS could serve as an efficient, noninvasive, accessible, and cost-effective tool for estimating the severity of endometriosis and predicting the complexity level of laparoscopic surgery based on the RANZCOG/AGES surgical skill levels.</p>","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of prednisone on vasectomy reversal outcomes (iPRED study): results from a randomized, controlled clinical trial.","authors":"Landon Trost, Sevann Helo, Klinton Brearton, Riley Warner, Matthew Ziegelmann, Tobias Kohler, Joshua Savage","doi":"10.1016/j.fertnstert.2024.11.019","DOIUrl":"10.1016/j.fertnstert.2024.11.019","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the safety and efficacy of prednisone on pregnancy rates and semen concentrations at 1 year after vasectomy reversal.</p><p><strong>Design: </strong>Randomized, controlled trial (NCT04788823).</p><p><strong>Setting: </strong>Single medical center specializing in vasectomy reversals.</p><p><strong>Patient(s): </strong>Men undergoing vasectomy reversal.</p><p><strong>Intervention(s): </strong>Participants were randomly assigned 1:1:1:1 to Control (no prednisone), Pred High (20 mg prednisone taper, every other month × 3 months), Pred PRN (20 mg prednisone taper × 3 courses maximum if sperm counts were declining or 0), and Pred Low (5 mg/d, every other week × 6 months). Note that Pred High and Pred PRN were stopped prematurely due to interim findings demonstrating lower pregnancy rates.</p><p><strong>Main outcome measure(s): </strong>Pregnancy rates, semen concentrations, and adverse events. The current study reports outcomes at 1 year.</p><p><strong>Result(s): </strong>A total of 75 men were enrolled, with 1-year data available in 73 (Control, n = 25; Pred High, n = 14; Pred PRN, n = 11; and Pred Low, n = 23). Baseline factors were similar among cohorts. Pregnancy rates at 12 months were higher in Controls (65%) and Pred Low (67%) compared with Pred High (17%) and Pred PRN (38%). Overall patency at 12 months (sperm at any point) was 99%, with no statistically significant differences noted between groups for patency, median concentrations by month (range, 3-42), or overall median concentrations (median of medians range, 5-16).</p><p><strong>Conclusion(s): </strong>High-dose (20 mg) prednisone results in decreased pregnancy rates after vasectomy reversal, an effect which is independent of sperm concentration, dose dependent, and persists for months after discontinuation. Prednisone doses (ranging from 5 to 20 mg) do not impact sperm concentrations.</p><p><strong>Clinical trial registration number: </strong>NCT04788823 (https://clinicaltrials.gov/study/NCT04788823?term=NCT04788823&rank=1).</p>","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"The role of assisted hatching in in vitro fertilization: a guideline\" (Fertil Steril 2022;117:1177-82).","authors":"","doi":"10.1016/j.fertnstert.2024.10.034","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2024.10.034","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ovarian tissue allografts: the next frontier of reproductive transplantation?","authors":"Kathryn Coyne, Isabelle Mason, Rebecca Flyckt","doi":"10.1016/j.fertnstert.2024.11.017","DOIUrl":"10.1016/j.fertnstert.2024.11.017","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Endometriosis and mental health disorders: identification and treatment as part of a multimodal approach.","authors":"Maria I Zervou, George N Goulielmos","doi":"10.1016/j.fertnstert.2024.11.014","DOIUrl":"10.1016/j.fertnstert.2024.11.014","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}