Epigenetic Implications of Socioeconomic Status and Education on Sperm DNA Methylation Patterns.

IF 6.6 1区医学 Q1 OBSTETRICS & GYNECOLOGY

Fertility and sterility Pub Date : 2024-10-16 DOI:10.1016/j.fertnstert.2024.10.010

Kelaney Stalker, Chad Pollard, Neil J Perkins, Elizabeth A DeVilbiss, Tim Jenkins

{"title":"Epigenetic Implications of Socioeconomic Status and Education on Sperm DNA Methylation Patterns.","authors":"Kelaney Stalker, Chad Pollard, Neil J Perkins, Elizabeth A DeVilbiss, Tim Jenkins","doi":"10.1016/j.fertnstert.2024.10.010","DOIUrl":null,"url":null,"abstract":"Objective: To identify differentially methylated regions (DMRs) and assess epigenetic age and instability scores within each cohort of differing income level and educational attainment.Design: Retrospective analysis of epigenetic data.Subjects: 1429 semen samples from participants in the FAZST trial.Exposure: Socio-economic status, approximated by self-reported income, and education level.Main outcome measures: Differential sperm DNA methylation, epigenetic age, epigenetic stability RESULTS: There were four significant DMRs associated with the income cohorts and seven associated with the education cohorts, suggesting epigenetic patterns vary with socio-economic status. Adjusted epigenetic age (GLAD values) did not differ significantly in either cohort; however, a higher number of unstable promoters were observed in the lowest education cohort (p-value of 0.006), indicating dysregulation in the epigenome.Conclusion: These findings suggest a biological link between income and education level in sperm epigenetic patterns, which may influence reproductive health. The increase in unstable promoters in the lower education cohorts may contribute to health disparities associated with educational attainment; however, it is important to consider lifestyle factors and environmental exposures as potential underlying causes. Further research is needed to fully elucidate the implications of these epigenetic changes and their relationship to health outcomes.","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6000,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fertility and sterility","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.fertnstert.2024.10.010","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: To identify differentially methylated regions (DMRs) and assess epigenetic age and instability scores within each cohort of differing income level and educational attainment.

Design: Retrospective analysis of epigenetic data.

Subjects: 1429 semen samples from participants in the FAZST trial.

Exposure: Socio-economic status, approximated by self-reported income, and education level.

Main outcome measures: Differential sperm DNA methylation, epigenetic age, epigenetic stability RESULTS: There were four significant DMRs associated with the income cohorts and seven associated with the education cohorts, suggesting epigenetic patterns vary with socio-economic status. Adjusted epigenetic age (GLAD values) did not differ significantly in either cohort; however, a higher number of unstable promoters were observed in the lowest education cohort (p-value of 0.006), indicating dysregulation in the epigenome.

Conclusion: These findings suggest a biological link between income and education level in sperm epigenetic patterns, which may influence reproductive health. The increase in unstable promoters in the lower education cohorts may contribute to health disparities associated with educational attainment; however, it is important to consider lifestyle factors and environmental exposures as potential underlying causes. Further research is needed to fully elucidate the implications of these epigenetic changes and their relationship to health outcomes.

查看原文本刊更多论文

社会经济地位和教育对精子 DNA 甲基化模式的表观遗传学影响

摘要确定不同甲基化区域（DMRs），评估不同收入水平和教育程度人群的表观遗传年龄和不稳定性得分：设计：对表观遗传学数据进行回顾性分析：暴露：社会经济地位，近似于自我报告的收入和教育水平：结果：有4个显著的DMRs与收入组群相关，7个与教育组群相关，表明表观遗传模式随社会经济地位而变化。调整后的表观遗传年龄（GLAD 值）在两个队列中没有显著差异；然而，在教育程度最低的队列中观察到较多的不稳定启动子（p 值为 0.006），表明表观遗传组中存在失调：这些研究结果表明，在精子表观遗传模式中，收入和教育水平之间存在生物学联系，这可能会影响生殖健康。教育程度较低的人群中不稳定促进因子的增加可能会导致与教育程度相关的健康差异；然而，重要的是要将生活方式因素和环境暴露作为潜在的根本原因。要充分阐明这些表观遗传变化的影响及其与健康结果的关系，还需要进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Fertility and sterility 医学-妇产科学

CiteScore

11.30

自引率

6.00%

发文量

1446

审稿时长

31 days

期刊介绍： Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.