Fertility and sterility最新文献

{"title":"The power of peer review and the wonderful partnership between the Centers for Disease Control and Prevention and Society for Assisted Reproductive Technology: we must keep them together","authors":"Louisa Drake D.O., Daniel Grow M.D.","doi":"10.1016/j.fertnstert.2025.07.012","DOIUrl":"10.1016/j.fertnstert.2025.07.012","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"124 4","pages":"Pages 653-654"},"PeriodicalIF":7.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Denosumab and the continuing search for novel treatments in male infertility","authors":"Corey A. Able M.D. , Taylor P. Kohn M.D., M.Phil.","doi":"10.1016/j.fertnstert.2025.07.009","DOIUrl":"10.1016/j.fertnstert.2025.07.009","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"124 4","pages":"Page 647"},"PeriodicalIF":7.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144612817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uterine peristalsis: a dynamic dilemma","authors":"Jose Carugno M.D. , Luis Alonso Pacheco M.D. , Nash Moawad M.D., M.S.","doi":"10.1016/j.fertnstert.2025.06.040","DOIUrl":"10.1016/j.fertnstert.2025.06.040","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"124 4","pages":"Pages 655-656"},"PeriodicalIF":7.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced maternal age was associated with an annual decline in reproductive success despite use of donor oocytes: a retrospective study","authors":"Patricia Sebastian-Leon Ph.D. , Francisco Jose Sanz Ph.D. , Pietro Molinaro M.D. , Antonio Pellicer M.D., Ph.D. , Patricia Diaz-Gimeno Ph.D.","doi":"10.1016/j.fertnstert.2025.05.150","DOIUrl":"10.1016/j.fertnstert.2025.05.150","url":null,"abstract":"<div><h3>Objective</h3><div>To study if there is an increasing risk of poor reproductive outcomes associated with age in in vitro fertilization (IVF) patients using donor oocytes, and when it becomes clinically relevant.</div></div><div><h3>Design</h3><div>Multicenter, retrospective cohort study.</div></div><div><h3>Subjects</h3><div>IVF patients ≥35 years at 19 private fertility clinics in Spain.</div></div><div><h3>Exposure</h3><div>A single day 5 embryo from a donor oocyte (<35 years) was transferred to the IVF patient undergoing hormone replacement therapy, between February 2000 and September 2022.</div></div><div><h3>Main Outcome Measures</h3><div>Live birth, implantation failure, and pregnancy loss rates were analyzed using a continuous scale of women’s ages to determine the gradual effect of age that is clinically relevant. The relative risks (RRs) of pregnancy loss and implantation failure after 40 years of age were calculated, adjusting for body mass index, IVF cycle parameters, and the embryo’s developmental stage and euploidy.</div></div><div><h3>Results</h3><div>Analysis of 33,141 good-quality, single embryo transfers identified the maternal age at which reproductive rates worsened as 39, 40 and 43 years for implantation failure, live birth, and pregnancy loss rates, respectively. Before live birth rates drastically decreased, there was no significant increment in the RR for negative outcomes. Nevertheless, after the age of 40, the RR of implantation failure increased by 4.2% per year (RR = 1.042, 95% Confidence interval [CI]: 1.028–1.056) whereas that of pregnancy loss increased by 3.2% per year (RR = 1.032, 95% CI: 1.013–1.051).</div></div><div><h3>Conclusion</h3><div>Challenging traditional paradigms that embryo factors drive the detrimental effect of age on reproductive outcomes, this study reveals that uterine age may also play a significant role in age-related detrimental effects. Given that embryo factors were controlled for, these findings suggest that the worsening of reproductive outcomes is associated with the effects of age in the uterus. In addition, this study design identified the specific age at which the live birth rate decreases, and the implantation failure rate and pregnancy loss rate increase. Our results encourage further study of how uterine age annually impacts pregnancy rates and support the uterus becoming a potential target for antiaging therapies aiming to improve outcomes of assisted reproductive technologies.</div></div><div><div>La edad materna avanzada se asoció con una disminución anual en el éxito reproductivo a pesar del uso de ovocitos donados: un estudio retrospectivo</div></div><div><h3>Objetivo</h3><div>Estudiar si existe un riesgo aumentado de resultados reproductivos desfavorables asociados con la edad en pacientes de fertilización in vitro (FIV) que utilizan ovocitos donados, y cuándo este riesgo se vuelve clínicamente relevante.</div></div><div><h3>Diseño</h3><div>Estudio de cohorte retros","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"124 4","pages":"Pages 635-644"},"PeriodicalIF":7.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative ultrasound measurement of uterine contractility in septate uterus vs. normal uteri: a multicenter prospective study","authors":"Brunella Zizolfi M.D., Ph.D. , Connie Odette Rees M.D., Ph.D. , Mariateresa Musone M.D. , Fabiola Nardelli M.D. , Virginia Foreste M.D. , Yizhou Huang Ph.D. , Anyi Cheng M.Sc. , Massimo Mischi Ph.D. , Benedictus Christiaan Schoot M.D., Ph.D. , Attilio Di Spiezio Sardo M.D., Ph.D.","doi":"10.1016/j.fertnstert.2025.05.159","DOIUrl":"10.1016/j.fertnstert.2025.05.159","url":null,"abstract":"<div><h3>Objective</h3><div>To study the differences in uterine contractility in women with septate uterus compared with those with a normal uterus throughout the menstrual cycle using a quantitative two-dimensional transvaginal ultrasound speckle tracking method.</div></div><div><h3>Design</h3><div>A multicenter prospective observational study was performed from February 2023 to July 2024.</div></div><div><h3>Subjects</h3><div>Fifty-seven patients with a diagnosis of septate uterus and seventy-one patients with a normal uterus, all of reproductive age, were enrolled at the Gynecology Departments of the University of Naples Federico II (Italy) and the Catharina Hospital in Eindhoven (Netherlands).</div></div><div><h3>Exposure</h3><div>A four-minute two-dimensional transvaginal ultrasound video in a median sagittal section of the uterus was performed throughout the various phases of the menstrual cycle to evaluate uterine contractility features, using a speckle tracking algorithm.</div></div><div><h3>Main Outcome Measures</h3><div>Uterine contractility features were analyzed in all patients diagnosed with a septate uterus, including contraction frequency (in contractions per minute), amplitude, direction, median velocity (mm/sec), and coordination measured in mean squared error.</div></div><div><h3>Results</h3><div>Regardless of the cycle phase, patients with a septate uterus exhibited statistically significant trends of decreased contraction frequency, velocity, and amplitude, along with poorer contraction coordination, compared with patients with normal uterus. In the luteal phase, when contractions are typically quiescent to facilitate embryo implantation, an increase in contraction frequency (1.27 ± 0.21 vs. 1.10 ± 0.12), contraction velocity in posterior wall from cervix to fundus (0.90 ± 0.23 vs. 0.70 ± 0.09), contraction velocity in posterior wall from fundus to cervix (0.91 ± 0.23 vs. 0.71 ± 0.08) and a decrease in contraction coordination (0.41 ± 0.16 vs. 0.20 ± 0.08) were reported in septate uteri. Furthermore, when considering two subgroups–partial and complete septate uteri compared with normal uteri–data indicated a greater impairment of uterine contractility in partial septate uteri when compared with normal uteri.</div></div><div><h3>Conclusion</h3><div>The presence of uterine pathologies, such as a septate uterus, may alter uterine peristalsis. A deeper understanding of uterine peristalsis in congenital anomalies could illuminate the link between the septate uterus and infertility.</div></div><div><h3>Trial registration</h3><div>number NL52466.100.15.</div></div><div><div>Medición ecográfica cuantitativa de la contractilidad uterina en útero tabicado vs. útero normal: un estudio prospectivo multicéntrico.</div></div><div><h3>Objetivo</h3><div>Estudiar las diferencias en la contractilidad uterina en mujeres con útero tabicado en comparación con aquellas con útero normal a lo largo del ciclo menstrual, utilizando un método cuantitati","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"124 4","pages":"Pages 728-736"},"PeriodicalIF":7.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incorporating embryoscopy into the treatment and evaluation of first-trimester pregnancy loss: is it ready for prime time?","authors":"Archana Ayyar M.D., Joseph Findley M.D.","doi":"10.1016/j.fertnstert.2025.07.011","DOIUrl":"10.1016/j.fertnstert.2025.07.011","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"124 4","pages":"Pages 664-665"},"PeriodicalIF":7.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Male obesity impairs early embryonic development and increases miscarriage risk in oocyte donation cycles.","authors":"Andreu Quintana-Vehí,Irene Miguel-Escalada,Debora Scaraboto,Filippo Zambelli,Daniel Mataró,Maria Jose Zamora,Maria Oliver-Bonet,Aïda Pujol,Amelia Rodriguez-Aranda,Mina Popovic","doi":"10.1016/j.fertnstert.2025.09.035","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.09.035","url":null,"abstract":"OBJECTIVETo evaluate the impact of male body mass index (BMI) on preimplantation development and clinical outcomes in oocyte donation cycles.DESIGNRetrospective cohort study.SUBJECTSA total of 7,846 embryos from 1,398 oocyte donation ICSI cycles were analyzed. Cycles utilized fresh (n = 904) or cryopreserved (n = 494), partner (n = 1,133) or donor sperm (n = 265). Cycles involving severe male factor or preimplantation genetic testing were excluded.EXPOSUREMale body mass index (BMI, kg/m2) at cycle start, categorized as normal weight (BMI < 24.9, n = 699), overweight (BMI = 25.0-29.9, n = 561), or obese (BMI ≥ 30, n = 138).MAIN OUTCOME MEASURESThe primary outcome focused on the timing of preimplantation developmental milestones assessed through morphokinetics. Secondary outcomes included embryo quality, fertilization, blastocyst, implantation, miscarriage, and live birth rates. Outcomes of the first fresh (n = 1,136) or frozen (n = 200), cleavage (n = 422) or blastocyst stage (n = 914) transfer were included, comprising 1,097 single and 239 double embryo transfers. Univariate analyses and logistic regression were used to evaluate associations between BMI, embryo morphokinetics and clinical outcomes.RESULTSEmbryos from obese males showed delayed cleavage-stage development (t2, t3, t4, and t5) and reduced odds of a good-quality inner cell mass in blastocysts, compared to those from normal weight males (OR = 0.80; 95% CI = 0.64-0.99; p = 0.04). Fertilization (normal weight: 75.1%, overweight: 74.6%, obese: 73.1%) and blastocyst rates (normal weight: 65.1%, overweight: 63.6%, obese: 63.8%) were comparable among the BMI groups. Implantation (normal weight: 64.8%, overweight: 64.3%, obese: 58.7%) and clinical pregnancy rates (normal weight: 60.0%, overweight: 58.9%, obese: 52.9%) were also similar. However, miscarriage rates were significantly higher among couples with obese males (13.5%) compared to those with normal weight males (9.5%) (OR = 1.67; 95% CI = 1.27-2.19; p = 0.0002). While not statistically significant, live birth rates followed a similar trend (normal weight: 46.7%, overweight: 43.7%, obese: 36.5%).CONCLUSIONMale obesity impairs early embryonic development and increases miscarriage rates, identifying male BMI as a potential risk factor in oocyte donation cycles.","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"20 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of antibiotic treatment on pregnancy outcomes in patients with mild chronic endometritis undergoing in vitro fertilization","authors":"Yiyao Xu M.Sc. ,&nbsp;Pik Ying Kwan M.Sc. ,&nbsp;Wenjun Chen M.Sc. ,&nbsp;Qingyan Zhang M.D., Ph.D. ,&nbsp;Canquan Zhou M.D., Ph.D. ,&nbsp;Ben W. Mol M.D., Ph.D. ,&nbsp;Yanwen Xu M.D., Ph.D. ,&nbsp;Fang Gu M.D., Ph.D.","doi":"10.1016/j.fertnstert.2025.05.172","DOIUrl":"10.1016/j.fertnstert.2025.05.172","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;&lt;span&gt;To study whether antibiotic&lt;span&gt; treatment improves the pregnancy outcomes of frozen-thawed embryo transfer (FET) in infertile patients diagnosed with mild chronic &lt;/span&gt;&lt;/span&gt;endometritis (CE).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Design&lt;/h3&gt;&lt;div&gt;Propensity score-matched cohort study.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Subjects&lt;/h3&gt;&lt;div&gt;&lt;span&gt;Women undergoing hysteroscopy with &lt;/span&gt;endometrial biopsy&lt;span&gt;&lt;span&gt; for previous failures of embryo transfer, history of recurrent pregnancy loss (RPL), abnormal &lt;/span&gt;uterine bleeding&lt;span&gt; or suspicious of endometrial lesions (i.e., polyps, uterine adhesion) seen on transvaginal ultrasound. Mild CE was defined as 1–4 CD138+ endometrial stromal plasmacytes (ESPCs) per high-power field (HPF).&lt;/span&gt;&lt;/span&gt;&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Exposure&lt;/h3&gt;&lt;div&gt;&lt;span&gt;Patients with mild CE received 14 days of empirical antibiotic therapy (doxycycline, 100 mg, twice daily or levofloxacin&lt;span&gt; lactate, 500 mg, once daily plus metronidazole, 200 mg, 3 times daily) or no treatment before single &lt;/span&gt;&lt;/span&gt;blastocyst FET.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Main Outcome Measures&lt;/h3&gt;&lt;div&gt;The primary outcome was live birth. Secondary outcomes included other fertility outcomes such as clinical pregnancy and early pregnancy loss, as well as perinatal outcomes.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;A total of 681 patients were diagnosed with mild CE, of whom 303 received antibiotics and 378 did not receive antibiotics. After propensity score matching, 303 pairs of patients were generated for comparative analysis. Live birth rate (LBR) between the antibiotics and untreated group was not significantly different (47.5% vs. 51.8%, relative risk [RR] 0.92, 95% confidence interval [CI] 0.78–1.08). All other reproductive, pregnancy and perinatal outcomes were also comparable. No significant differences were observed in fertility outcomes between the antibiotics and untreated cohorts across a range of cut-off values for the CD138 categories (from 1 ESPCs/HPF to ≤4 ESPCs/HPF), although severity of infection had no impact on the prognosis.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;In this cohort study, we did not find an indication that antibiotic treatment improves pregnancy outcomes in patients with mild CE. Additionally, a higher CD138 category did not affect the prognosis.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;div&gt;Efecto del tratamiento antibiótico en los resultados del embarazo en pacientes con endometritis crónica leve sometidas a fertilización in vitro.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objetivo&lt;/h3&gt;&lt;div&gt;Estudiar si el tratamiento con antibióticos mejora los resultados del embarazo tras la transferencia de embriones congelados-descongelados (TEC) en pacientes infértiles con diagnóstico de endometritis crónica (EC) leve.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Diseño&lt;/h3&gt;&lt;div&gt;Estudio de cohorte con emparejamiento por puntaje de propensión.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Sujetos&lt;/h3&gt;&lt;div&gt;Mujeres sometidas a histeroscopía con biopsia endometrial por fracasos previos de transferencia de embriones, antecedentes","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"124 4","pages":"Pages 711-719"},"PeriodicalIF":7.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blastocysts derived from 0-pronuclear and 1-pronuclear zygotes represent an untapped pool of usable embryos","authors":"Arielle S. Yeshua M.D. ,&nbsp;Kerry Flannagan Ph.D. ,&nbsp;Joseph Lee B.A. ,&nbsp;Benjamin S. Harris M.D., M.P.H. ,&nbsp;Teresa Cacchione M.S., C.G.C. ,&nbsp;Kate Devine M.D. ,&nbsp;Eugene Toh B.S., M.Sc. ,&nbsp;Amy Jordan M.S. ,&nbsp;Cengiz Cinnioglu Ph.D. ,&nbsp;Phillip Romanski M.D., M.Sc.","doi":"10.1016/j.fertnstert.2025.04.041","DOIUrl":"10.1016/j.fertnstert.2025.04.041","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"124 4","pages":"Pages 775-777"},"PeriodicalIF":7.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143921010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preimplantation genetic testing for aneuploidy—the three wise monkeys","authors":"Raoul Orvieto M.D., M.M.Sc.","doi":"10.1016/j.fertnstert.2025.04.049","DOIUrl":"10.1016/j.fertnstert.2025.04.049","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"124 4","pages":"Pages 787-788"},"PeriodicalIF":7.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}