Fertility and sterility最新文献

{"title":"Persistence of hypertension after pregnancy-related hypertensive disorders in women with polycystic ovary syndrome.","authors":"Stefano Palomba,Flavia Costanzi,Rossella Cannarella,Raffaella Votino,Aldo E Calogero,Fabrizio Signore,Donatella Caserta","doi":"10.1016/j.fertnstert.2025.04.026","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.04.026","url":null,"abstract":"OBJECTIVEThis study aims to assess whether polycystic ovary syndrome (PCOS) increases the risk of persistent hypertension in women with a history of pregnancy-induced hypertensive disorder (PHD).DESIGNA single-center, prospective cohort study.SUBJECTSA total of 124 patients with PHD were enrolled. PHD was diagnosed based on the presence of pregnancy-induced hypertension (PIH) or preeclampsia (PE). All PHD patients were screened for PCOS diagnosis, which was confirmed or excluded based on patient history and clinical reports. Sixty-two patients diagnosed with PCOS (n=62, cases) were included as the study group. After one-to-one matching process based on age-, body mass index-, and infertility treatment, 62 control patients without PCOS were also included.EXPOSUREPCOS diagnosis according to National and International criteria.MAIN OUTCOME MEASURESThe primary outcome was the persistence of hypertension 12 months after delivery. Secondary outcomes included persistence of hypertension at 3 and 6 months from delivery, pregnancy complications and data on antihypertensive treatment.RESULTSAfter 12 months from delivery, the risk of persistent hypertension was significantly higher in PHD patients with PCOS compared to controls (adjusted odds ratio [aOR] 4.51, 95% confidence interval [CI] 1.43-14.19, p=0.010). At 6 months, that risk was also significantly higher (aOR 5.01, 95% CI 1.63-15.94, p=0.005). Additionally, pregnant PCOS patients had an earlier onset of PHD (30.0 vs. 31.1 weeks, p=0.013), required a higher dose of nifedipine (37.5 mg vs. 30 mg, p=0.001), and were more likely to receive antihypertensive therapy with multiple drugs (24.2% vs. 9.7%, p=0.032) compared to controls. The incidence of fetal growth restriction (19.4% vs. 6.5%, p=0.033), abnormal Doppler velocimetry (16.1% vs. 4.8%, p=0.041), and cesarean delivery (35.5% vs. 19.4%, p=0.019) was also significantly higher in the PCOS group compared to controls.CONCLUSIONPCOS is associated with an increased risk of persistent hypertension in patients with a history of PHD. Preventive interventions before pregnancy, specific pregnancy surveillance, and long-term follow-up should be recommended for women with PCOS.","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"8 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cumulative pre-trigger progesterone levels are not superior to single-day levels for predicting a failed cycle in fresh embryo transfer cycles.","authors":"Meghan Yamasaki,Kerry Flannagan,David Boedeker,Shelley Dolitsky,Nicole Banks,Alan Decherney,Eduardo Hariton,Benjamin S Harris,Anthony Imudia,Caleb Kallen,Jessica Kanter,Michael Levy,Phillip Romanski,Meike Uhler,Kate Devine,Micah Hill","doi":"10.1016/j.fertnstert.2025.04.024","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.04.024","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"45 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Milestone to Mainstream: The Case for Uterus Transplantation.","authors":"Elliott G Richards","doi":"10.1016/j.fertnstert.2025.04.020","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.04.020","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"10 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hysteroscopic visualization and resection of embryo in biochemical pregnancy loss.","authors":"Xiaoyan Guo,Ziyu Zhou,Chichi Xie,Honghong Zhang,Yiqi Yu,Weihai Xu,Jing Shu,Yanpeng Wang","doi":"10.1016/j.fertnstert.2025.04.013","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.04.013","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"10 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Between Scylla and Charybdis: Academic Ob-Gyn Departments Need to Choose!","authors":"Steven Young,Ruben Alvero","doi":"10.1016/j.fertnstert.2025.04.022","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.04.022","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"3 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PGT-A and Cumulative Pregnancy Rates: A Closer Look at the Evidence.","authors":"Ramazan Mercan","doi":"10.1016/j.fertnstert.2025.04.016","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.04.016","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"24 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients with a body mass index ≥45 kg/m2 can safely undergo oocyte retrievals and anticipate similar assisted reproductive technology outcomes.","authors":"Marissa Luck,Elizabeth Rubin,Bharti Garg,Stephanie Powell,Thomas O'Leary,Paula Amato,Diana Wu,David Lee,Lynn Bentley Davis,Sacha Krieg","doi":"10.1016/j.fertnstert.2025.04.014","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.04.014","url":null,"abstract":"OBJECTIVETo compare anesthesia and assisted reproductive technology (ART) outcomes in patients with a body mass index (BMI) of 40-44.9kg/m2 to those with a BMI ≥45kg/m2 as these patients are often excluded from care.DESIGNRetrospective cohort study SUBJECTS: All patients with a BMI ≥40kg/m2 undergoing oocyte retrieval for ART from January 2018-2023 from one academic fertility clinic and one private fertility clinic.EXPOSUREBMI ≥45kg/m2 compared to a BMI of 40-44.9kg/m2.MAIN OUTCOME MEASURESThe primary outcome was anesthesia complications at the time of retrieval. Demographic data, cycle specific information, medical comorbidities, BMI at retrieval, length of oocyte retrieval, ART and anesthesia complications, laboratory data, and pregnancy rates were recorded.RESULTSA total of 98 patients with a BMI ≥40kg/m2 undergoing oocyte retrieval were identified for the study, 56 patients with a BMI from 40-44.9kg/m2 and 42 patients with a BMI ≥45kg/m2. Demographics were not statistically different between both groups, except more patients with a BMI 40-44.9 kg/m2 identified as White (73% vs 60%) or Black (9% vs 0%), p=0.03. All patients were successfully managed with intravenous sedation and did not require higher level of sedation or care. Mean surgical duration was longer for patients with a BMI ≥45 kg/m2 than in those with a with a BMI 40-44.9 kg/m2 (26.8min, SD 13min vs. 22.3min, SD 8.4min, p=0.04). Most patients (93%) did not experience any anesthesia complication. The only adverse anesthesia complication in both groups was oxygen desaturation <90%, which did not differ by cohort even when adjusting for age. There was no difference in the number of mature oocytes retrieved, day 5/6 blastocysts, the number of euploid embryos, clinical pregnancy, miscarriage or live birth rates.CONCLUSIONBMI is commonly used as a threshold for access to ART. When using intravenous sedation, patients with BMI ≥45 kg/m2 have similar ART outcomes with few anesthesia or ART complications in comparison to patients with a BMI of 40-44.9 kg/m2. With appropriate counseling and preoperative preparation, patients with a BMI ≥45 kg/m2 can safely undergo oocyte retrieval.","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"31 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143866442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DO YOU REQUIRE ANY ASSISTANCE? - ASSISTED HATCHING MAY HAVE NEGATIVE IMPACT ON CYCLES USING VITRIFIED/WARMED DONOR OOCYTES.","authors":"Zachary Walker","doi":"10.1016/j.fertnstert.2025.04.018","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.04.018","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"21 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143866443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INTRATESTICULAR AUTOLOGOUS PLATELET RICH PLASMA INJECTION IN COUPLES WITH NON-OBSTRUCTIVE AZOOSPERMIA: A NARRATIVE REVIEW.","authors":"Yigit Cakiroglu,Tansu Gudelci,Bulent Tiras","doi":"10.1016/j.fertnstert.2025.04.011","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.04.011","url":null,"abstract":"Azoospermia is the most severe form of male infertility presenting around 1% of the male population and 5%-10% of infertile men. Azoospermia is classified into two categories: obstructive azoospermia (OA) and non-obstructive azoospermia (NOA). Currently, micro Testicular Sperm Extraction (mTESE) is still the primary approach especially for cases with NOA. However, there are still some NOA patients in whom sperm can not be yielded even after repeated mTESE attempts. Besides, no definitive alternative treatments exist, prompting ongoing research into new approaches for restoring spermatogenesis in NOA patients. This review focuses on the current literature regarding the possible role of intratesticular autologous platelet rich plasma injection in couples with non-obstructive azoospermia. First, we give an overview of the pathophysiology of azoospermia and the sperm retrieval techniques in azoospermia. Subsequently, we give information about platelet rich plasma (PRP), and briefly discuss the role of PRP on ovaries and endometrium in the light of literature. Finally, we review the current literature on the testicular administration of PRP on animal models and on human. As a conclusion, the findings of the present review suggests that autologous PRP therapy shows promise as a novel approach in male infertility, especially for NOA patients. Nevertheless, additional investigation through randomized controlled trials is necessary to refine the technique and determine its effectiveness to answer the question of whether PRP could significantly improve the second attempt retrieval rate after a failed previous mTESE procedure.","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"52 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143866444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strengthening Systematic Review Methods: Reflections on GRADE, Risk of Bias, and Clinical Relevance.","authors":"Alessandro Conforti,Sandro C Esteves,Carlo Alviggi","doi":"10.1016/j.fertnstert.2025.04.012","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.04.012","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"28 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}