Fertility and sterility最新文献

{"title":"Racial and ethnic differences in gestational carriers: Assessment of obstetric characteristics and outcomes.","authors":"Aaron D Masjedi, Zachary S Anderson, Laurel S Aberle, Katherine V Erickson, Jennifer A Yao, Shinya Matsuzaki, Rachel S Mandelbaum, Joseph G Ouzounian, Richard J Paulson, Koji Matsuo","doi":"10.1016/j.fertnstert.2025.03.015","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.03.015","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of medically assisted reproduction and the risk of multiple live birth across sexual orientation groups-results from a national longitudinal cohort.","authors":"Brent Monseur, Tabor Hoatson, Kodiak R S Soled, Colleen A Reynolds, S Bryn Austin, Sebastien Haneuse, Ruth B Lathi, Juno Obedin-Maliver, Brittany M Charlton","doi":"10.1016/j.fertnstert.2025.03.012","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.03.012","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibition of ovulation and pharmacologic mechanism of action of relugolix combination therapy.","authors":"I J M Duijkers, C Klipping, C Draeger, B S Schug, R-S Wedemeyer, Y Li, J C Arjona Ferreira, E M Migoya","doi":"10.1016/j.fertnstert.2025.03.011","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.03.011","url":null,"abstract":"<p><strong>Objective: </strong>To assess the effects of relugolix combination therapy on ovarian function in healthy, ovulatory, premenopausal women.</p><p><strong>Design: </strong>This was an open-label, single-cohort, pharmacodynamic, safety and tolerability study consisting of five study periods: a Pre-Treatment Period to confirm ovulatory status, three 28-day treatment periods, and a Post-Treatment Period to assess duration of time required to return to ovulation following treatment discontinuation. Ovarian function was assessed by transvaginal ultrasonography and serum hormone concentrations.</p><p><strong>Subjects: </strong>Healthy, premenopausal female participants, 18-35 years of age.</p><p><strong>Intervention/exposure: </strong>Relugolix combination therapy (relugolix 40 mg, with estradiol 1 mg and norethindrone acetate 0.5 mg) was taken orally once daily for 84 days.</p><p><strong>Main outcome measures: </strong>The primary endpoint was the proportion of women in whom ovulation was inhibited during the entire 84-day treatment period. Secondary endpoints included proportion of women in whom ovulation was inhibited within each treatment period, number of women who fulfilled the Landgren criterion; characterization of follicular diameter, hormone concentrations, and endometrial thickness; time to return to ovulation following treatment discontinuation; proportion of women who returned to ovulation within 36 days following treatment discontinuation; safety and tolerability.</p><p><strong>Results: </strong>Seventy women were enrolled in the study, 67 of whom completed treatment. Treatment with relugolix combination therapy inhibited ovulation in 100% of women who completed treatment (95% confidence interval: 94.6, 100.0). Systemic concentrations of luteinizing hormone and follicle-stimulating hormone were suppressed and maintained at low concentrations during treatment, with an absence of a preovulatory luteinizing hormone surge. Median estradiol concentrations across all women were consistently maintained between 36.8 and 39.1 pg/mL (range: 12.1-121.1 pg/mL) during treatment. All individual progesterone concentrations during treatment remained below 1.57 ng/mL (5 nmol/L). Following treatment discontinuation, all women ovulated or initiated menses. The mean time to return to ovulation was 23.5 days. Treatment was generally well tolerated with no safety or tolerability issues identified.</p><p><strong>Conclusion: </strong>Relugolix combination therapy inhibits ovulation, which, in the context of this study, was achieved within the first cycle following treatment initiation. The rapid and predictable return of ovarian activity and ovulation following treatment discontinuation is advantageous for patients who wish to conceive thereafter.</p>","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Nationwide Analysis of the Trends in Permanent Contraception Utilization Before and After the Dobbs Ruling.","authors":"John Wahlstedt, Eric Wahlstedt, Joemy Ramsay, Alexandra Woodcock, Jessica Sanders, Misha Pangasa, David Turok, Kelli Gross, James Hotaling, Jessica Schardein","doi":"10.1016/j.fertnstert.2025.03.013","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.03.013","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fertility under fire: navigating patient counseling in a Post-Dobbs world.","authors":"Alexandra Minnihan, Allison Bosch, Mindy S Christianson","doi":"10.1016/j.fertnstert.2025.02.035","DOIUrl":"10.1016/j.fertnstert.2025.02.035","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal Follicle Size for hCG Trigger in Mono-Follicular Growth during Letrozole-Induced IUI Cycles: Findings from a Large Retrospective Study.","authors":"Krista Cameron, Basim Abu-Rafea, Angelos Vilos, Jackie Hollett-Caines, Maggie Rebel, Matthew Van Oirschot, Ali Mourad","doi":"10.1016/j.fertnstert.2025.03.010","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.03.010","url":null,"abstract":"<p><strong>Objective: </strong>To determine the optimal lead follicle size for hCG trigger in letrozole intrauterine insemination (IUI) cycles, focusing on pregnancy outcomes.</p><p><strong>Design: </strong>Retrospective cohort study.</p><p><strong>Subjects: </strong>724 letrozole-IUI cycles conducted at Omega Fertility Clinic between January 1, 2018, and September 30, 2023.</p><p><strong>Exposure: </strong>Patients received letrozole for ovulation induction from cycle days 3-7, with follicle development monitored via transvaginal ultrasound. hCG was administered when a lead follicle reached the desired size, followed by IUI.</p><p><strong>Main outcome measures: </strong>The primary outcome was clinical pregnancy rate. Lead follicle sizes were categorized (≤18 mm, 19-23 mm, ≥24 mm) and dichotomized using thresholds from the ROC curve and Youden's index.</p><p><strong>Results: </strong>Among 724 cycles, 92 resulted in clinical pregnancy. Clinical pregnancy rates were 8.45% for follicles ≤17 mm, 8.89% for 18 mm, and increased from 12.92% (19 mm) to 18.52% (22 mm) before declining to 11.43% for follicles ≥24 mm. Biochemical pregnancy rates followed a similar trend. Logistic regression revealed significantly higher odds of clinical pregnancy for follicles 19-23 mm (adjusted OR = 1.71, 95% CI: 1.01-3.03) compared to ≤18 mm. Follicles ≥24 mm had an adjusted OR of 1.80 (95% CI: 0.98-3.31), narrowly crossing the null, suggesting a possible effect despite not reaching statistical significance. The optimal threshold for follicle size was 19 mm, based on ROC curve analysis. Dichotomized analysis confirmed higher odds of clinical pregnancy for follicles ≥19 mm (adjusted OR = 1.74, 95% CI: 1.01-3.01).</p><p><strong>Conclusion: </strong>The optimal lead follicle size for hCG trigger in letrozole-IUI cycles is 19-23 mm, significantly improving clinical pregnancy rates. Follicles ≥24 mm may also yield positive outcomes and warrant further investigation. These findings provide evidence-based guidance for optimizing letrozole-IUI treatments.</p>","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fertility and Sterility top videos from 2022.","authors":"Joseph Findley, Zaraq Khan, John Preston Parry, Kira Eickman, Steven R Lindheim","doi":"10.1016/j.fertnstert.2025.03.002","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.03.002","url":null,"abstract":"<p><strong>Objective: </strong>To objectively grade all video publications in Fertility & Sterility during the year 2022 and compile a list of the top 10 surgical videos.</p><p><strong>Design: </strong>Descriptive presentation of the 10 highest scoring video publications from Fertility & Sterility in the year 2022.</p><p><strong>Subjects: </strong>Not applicable EXPOSURE: JF, ZK, JPP, and SRL acted as independent reviewers of all video publications. A standardized scoring method was used to score all videos.</p><p><strong>Main outcome measures: </strong>Up to 5 points were awarded for each of the following categories: Scientific merit or clinical relevance of the topic; clarity of video; use of innovative surgical technique; and video editing or use of marking tools on the video to highlight important features or surgical landmarks. This allowed a maximum score of 20 for each video. The number of YouTube views and likes were used as a tiebreaker if ≥2 videos scored similarly. The interclass coefficient from a 2-way random effects model was calculated to assess for agreement between the 4 independent reviewers.</p><p><strong>Result(s): </strong>A total of 32 videos were published in Fertility and Sterility during the year 2022. After averaging scores from all 4 reviewers, a top-10 list was created. The overall interclass correlation coefficient for the 4 reviews was 0.71 (95% confidence interval, 0.48-0.85).</p><p><strong>Conclusion(s): </strong>An overall substantial agreement was noted between the 4 reviewers. 10 videos stood out from a list of very competitive publications that had already undergone the peer review process. The subject matter of these videos ranged from complex surgical procedures, including uterine transplantation, to common gynecologic ultrasound procedures.</p>","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The strength of certainty and the power of words.","authors":"Demián Glujovsky, Agustin Ciapponi","doi":"10.1016/j.fertnstert.2025.03.008","DOIUrl":"10.1016/j.fertnstert.2025.03.008","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Y chromosome: male reproduction and beyond.","authors":"Csilla Krausz, Chiara Abrardo","doi":"10.1016/j.fertnstert.2025.03.006","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.03.006","url":null,"abstract":"<p><p>The crucial role of Y chromosome genes in male gonadal determination and reproductive fitness has been recognized for decades. Y chromosome microdeletions are the most common molecular genetic causes of azoospermia and severe spermatogenic impairment. Since the late 1990s, screening for these microdeletions has become a routine part of the diagnostic work-up of severe male factor infertility. In this article, we provide a concise overview of the Y chromosome's structure and gene content. We describe its clinically relevant alterations, detectable through karyotyping or molecular genetic tools, with a focus on their phenotypic impact and significance for genetic counselling. Finally, we discuss the broader implications of Y chromosome variations on health conditions beyond male infertility.</p>","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variable adoption of polycystic ovary syndrome-related infertility guidelines in the United States: a retrospective cohort and survey study.","authors":"Anne E Kim, Jeremy Applebaum, Iris T Lee, Edward K Kim, Minyoung Jang, Anuja Dokras, Divya K Shah","doi":"10.1016/j.fertnstert.2025.03.003","DOIUrl":"10.1016/j.fertnstert.2025.03.003","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}