Fertility and sterility最新文献

{"title":"Intrapatient variability in the number of retrieved oocytes","authors":"Raoul Orvieto M.D., M.M.Sc.","doi":"10.1016/j.fertnstert.2026.06.039","DOIUrl":"10.1016/j.fertnstert.2026.06.039","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"126 4","pages":"Page 753"},"PeriodicalIF":8.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149059650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deconstructing triglyceride glucose–body mass index in normal-weight women with polyendocrine metabolic ovarian syndrome","authors":"Daniel A. Dumesic M.D., Tristan R. Grogan M.S., Michelle M. Song B.S., Vibha Singhal M.P.H, M.B.B.S.","doi":"10.1016/j.fertnstert.2026.06.013","DOIUrl":"10.1016/j.fertnstert.2026.06.013","url":null,"abstract":"<div><h3>Objective</h3><div>To study the biological pathways underlying the triglyceride glucose–body mass index (TyG-BMI), calculated as natural logarithm (plasma triglyceride [mg/dL] × fasting blood glucose [mg/dL]/2) × body mass index (BMI), in normal-weight women with polyendocrine metabolic ovarian syndrome (PMOS) and age-/BMI-matched normoandrogenic ovulatory (control) women, and to determine whether the TyG-BMI in such women is a useful clinical predictor of reduced in vitro fertilization (IVF) pregnancy outcome.</div></div><div>To study the biological pathways underlying the triglyceride glucose–body mass index (TyG-BMI), calculated as natural logarithm (plasma triglyceride [mg/dL] × fasting blood glucose [mg/dL]/2) × body mass index (BMI), in normal-weight women with polyendocrine metabolic ovarian syndrome (PMOS) and age-/BMI-matched normoandrogenic ovulatory (control) women, and to determine whether the TyG-BMI in such women is a useful clinical predictor of reduced in vitro fertilization (IVF) pregnancy outcome.</div><div><h3>Design</h3><div>Retrospective cohort study</div></div><div>Retrospective cohort study</div><div><h3>Subjects</h3><div>Twenty-one normal-weight women with PMOS and 19 age- and BMI-matched controls.</div></div><div>Twenty-one normal-weight women with PMOS and 19 age- and BMI-matched controls.</div><div><h3>Exposure</h3><div>All women underwent fasting circulating metabolic/androgenic determinations.</div></div><div>All women underwent fasting circulating metabolic/androgenic determinations.</div><div><h3>Main Outcome Measures</h3><div>The TyG-BMI was compared between women with PMOS and age-/BMI-matched controls and correlated with metabolic/androgenic outcomes.</div></div><div>The TyG-BMI was compared between women with PMOS and age-/BMI-matched controls and correlated with metabolic/androgenic outcomes.</div><div><h3>Results</h3><div>Serum luteinizing hormone/androgen levels and fasting serum triglyceride/insulin levels were significantly greater in women with PMOS than controls. Adipose insulin resistance (adipose-IR) was also increased in women with PMOS vs. controls. The TyG-BMI and homeostasis model assessment of insulin resistance, however, were not significantly different by female type. In multivariable linear regression, TyG-BMI was unassociated with PMOS, serum free testosterone or fasting serum insulin levels. Instead, in all women combined, higher TyG-BMI levels were associated with greater adipose-IR, higher serum non-high-density lipoprotein cholesterol, and lower serum high-density lipoprotein cholesterol levels.</div></div><div>Serum luteinizing hormone/androgen levels and fasting serum triglyceride/insulin levels were significantly greater in women with PMOS than controls. Adipose insulin resistance (adipose-IR) was also increased in women with PMOS vs. controls. The TyG-BMI and homeostasis model assessment of insulin resistance, however, were not significantly different by female type. In multiva","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"126 4","pages":"Pages 722-729"},"PeriodicalIF":8.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148204685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Maternal Polyendocrine Metabolic Ovarian Syndrome with Offspring Ovarian Activity in Minipuberty","authors":"Lív Fossdal Guttesen,Gylli Mola,Hanne Frederiksen,Karin Sundberg,Hanne Kristine Hegaard,Anders Juul,Casper P. Hagen,Margit Bistrup Fischer","doi":"10.1016/j.fertnstert.2026.09.015","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2026.09.015","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"4 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between embryologist-related variability in blastocyst vitrification/warming and reproductive outcomes: a single-center retrospective study with external confirmation analysis","authors":"Federico Cirillo EFRM-ESHRE/EBCOG, Daria Marzanati C.E., Camilla Ronchetti M.D., Luca Pagliardini Ph.D., Greta Chiara Cermisoni C.E., Alessandra Alteri Ph.D., Emanuela Morenghi Ph.D., Ozgur Bulbul C.E., Martina Zoppetti M.D., Elena Albani C.E., Alessandro Bartolacci C.E., Enrico Papaleo M.D., Paolo Emanuele Levi-Setti","doi":"10.1016/j.fertnstert.2026.05.157","DOIUrl":"10.1016/j.fertnstert.2026.05.157","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"126 4","pages":"Pages 735-737"},"PeriodicalIF":8.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148053633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenic variants in GALNT3, GALNT8, and GALNTL5 are associated with distinct sperm defects in human asthenoteratozoospermia","authors":"Mohan Liu,Gan Shen,Tingting Lin,Chunyan Lu,Erpo Tian,Li Duan,Guicheng Zhao,Xiang Wang,Yanting Yang,Chanjuan Zhao,Xue Ren,Xun Zhou,Yunchuan Tian,Yingteng Zhang,Xiaohui Jiang,Yihong Yang,Ying Shen","doi":"10.1016/j.fertnstert.2026.10.009","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2026.10.009","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"11 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149208761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"True pelvic congenital arteriovenous malformation in a patient seeking pregnancy","authors":"Marisol Doglioli M.D., Sara Tolentino M.D., Sabato De Cicco M.D., Lucia De Meis M.D., Francesco Modestino M.D., Paolo Casadio M.D., Renato Seracchioli M.D., Ph.D., Alessandro Arena M.D., Ph.D.","doi":"10.1016/j.fertnstert.2026.07.017","DOIUrl":"10.1016/j.fertnstert.2026.07.017","url":null,"abstract":"<div><h3>Objective</h3><div>To describe the diagnostic challenges and management options of a rare case with congenital pelvic arteriovenous malformation (AVM) desiring pregnancy. AVMs are rare vascular anomalies which must be distinguished from acquired lesions associated with pregnancy-related events or uterine instrumentation. These malformations result from abnormal vessel development during embryogenesis, leading to direct arteriovenous connections without an interconnecting capillary bed. Their preoperative diagnosis is complex, particularly in women of reproductive age desiring fertility preservation, and can range from asymptomatic incidental findings to life-threatening hemorrhage. A delayed or missed diagnosis poses serious risks to patient survival and reproductive potential; therefore, it is important to recognize them and reserve individualized, multidisciplinary management, including advanced imaging, embolization, and potentially surgical intervention, if necessary.</div></div><div>To describe the diagnostic challenges and management options of a rare case with congenital pelvic arteriovenous malformation (AVM) desiring pregnancy. AVMs are rare vascular anomalies which must be distinguished from acquired lesions associated with pregnancy-related events or uterine instrumentation. These malformations result from abnormal vessel development during embryogenesis, leading to direct arteriovenous connections without an interconnecting capillary bed. Their preoperative diagnosis is complex, particularly in women of reproductive age desiring fertility preservation, and can range from asymptomatic incidental findings to life-threatening hemorrhage. A delayed or missed diagnosis poses serious risks to patient survival and reproductive potential; therefore, it is important to recognize them and reserve individualized, multidisciplinary management, including advanced imaging, embolization, and potentially surgical intervention, if necessary.</div><div><h3>Design</h3><div>A step-by-step narrated video of a rare clinical case and description of the diagnostic and management process.</div></div><div>A step-by-step narrated video of a rare clinical case and description of the diagnostic and management process.</div><div><h3>Subjects</h3><div>A 25-year-old nulligravid woman with congenital pelvic AVM presenting to the emergency department with abnormal uterine bleeding and subsequent desire for pregnancy.</div></div><div>A 25-year-old nulligravid woman with congenital pelvic AVM presenting to the emergency department with abnormal uterine bleeding and subsequent desire for pregnancy.</div><div><h3>Exposure</h3><div>Initial expectant management with counseling regarding pregnancy risks. Serial transvaginal ultrasound surveillance throughout pregnancy. Prophylactic uterine artery embolization performed immediately prior to planned cesarean delivery to minimize hemorrhagic risk.</div></div><div>Initial expectant management with counseling regarding p","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"126 4","pages":"Pages 751-752"},"PeriodicalIF":8.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148600861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uterus-sparing laparoscopic reversal of complete nonpuerperal uterine inversion: a rare case and challenging procedure","authors":"Athanasios Protopapas Ph.D., Nikolaos Kathopoulis Ph.D., Athanasios Douligeris M.D., Kyveli Aggelou M.D., Ioannis Chatzipapas Ph.D., Konstantinos Kypriotis M.D.","doi":"10.1016/j.fertnstert.2026.06.030","DOIUrl":"10.1016/j.fertnstert.2026.06.030","url":null,"abstract":"<div><h3>Objective</h3><div>To present а rare case of complete uterine inversion in a nonpregnant young woman who was managed successfully laparoscopically.</div></div><div>To present а rare case of complete uterine inversion in a nonpregnant young woman who was managed successfully laparoscopically.</div><div><h3>Design</h3><div>Video article with intraoperative narration and key surgical highlights.</div></div><div>Video article with intraoperative narration and key surgical highlights.</div><div><h3>Subjects</h3><div>A 24-year-old patient with a history of laparotomic staging for a granulosa-cell ovarian tumor was admitted as an emergency to the gynecological oncology department of our hospital, with sudden onset of intractable uterine bleeding, caused by a necrotic, hemorrhagic mass, protruding from the vagina.</div></div><div>A 24-year-old patient with a history of laparotomic staging for a granulosa-cell ovarian tumor was admitted as an emergency to the gynecological oncology department of our hospital, with sudden onset of intractable uterine bleeding, caused by a necrotic, hemorrhagic mass, protruding from the vagina.</div><div><h3>Exposure</h3><div>Transvaginal excision of the lesion was attempted under laparoscopic control. At laparoscopy, complete uterine inversion was found. Μaneuvers to correct the inversion were unsuccessful. Hemostatic sutures were placed, and the patient was referred to our unit for further management. Histopathology suggested uterine adenomyoma. The uterine inversion was successfully reversed with a combination of laparoscopic and vaginal maneuvers after vertical anterior and posterior uterine incisions to divide the cervical constriction ring. The uterine cavity was opened, previous sutures were removed, and the uterus was reconstructed with resuturing in two layers. A prophylactic cervical cerclage tape was placed laparoscopically.</div></div><div>Transvaginal excision of the lesion was attempted under laparoscopic control. At laparoscopy, complete uterine inversion was found. Μaneuvers to correct the inversion were unsuccessful. Hemostatic sutures were placed, and the patient was referred to our unit for further management. Histopathology suggested uterine adenomyoma. The uterine inversion was successfully reversed with a combination of laparoscopic and vaginal maneuvers after vertical anterior and posterior uterine incisions to divide the cervical constriction ring. The uterine cavity was opened, previous sutures were removed, and the uterus was reconstructed with resuturing in two layers. A prophylactic cervical cerclage tape was placed laparoscopically.</div><div><h3>Main Outcome Measures</h3><div>Anatomical restoration of the uterus.</div></div><div>Anatomical restoration of the uterus.</div><div><h3>Results</h3><div>At the six-month follow-up, the patient reported irregular cycles, without menorrhagia, and had a fairly normal-shaped uterus.</div></div><div>At the six-month follow-up, the patient reported ","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"126 4","pages":"Page 750"},"PeriodicalIF":8.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148365366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Office Hysteroscopic Removal of an IUD-Myoma Composite Using an 18.5 Fr Hysteroscope and Blue Laser in a Postmenopausal Woman with Cervical Atrophy: A No-Anesthesia Approach","authors":"Congqing Li,Fei Song,Liwei Zhang,Yingmei Sun","doi":"10.1016/j.fertnstert.2026.09.014","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2026.09.014","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"203 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarker or bystander? Triglyceride glucose–body mass index in patients with polyendocrine metabolic ovarian syndrome","authors":"Cecilia Rosenbaum M.D., M. Blake Evans D.O.","doi":"10.1016/j.fertnstert.2026.07.001","DOIUrl":"10.1016/j.fertnstert.2026.07.001","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"126 4","pages":"Page 730"},"PeriodicalIF":8.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148385145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are at-home and mail-in sperm tests reliable?","authors":"Sevann Helo,Dolores J. Lamb,Nahid Punjani,Michael L. Eisenberg","doi":"10.1016/j.fertnstert.2026.08.1128","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2026.08.1128","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"68 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}