Fertility and sterility最新文献

{"title":"\"The Birds, The Bees and The Blastocysts\".","authors":"Thomas A Molinaro,Maria Costantini-Ferrando","doi":"10.1016/j.fertnstert.2025.04.010","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.04.010","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"47 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of unicornuate uterus with pathological rudimentary horn: settling the associated adenomyosis with fertility preservation.","authors":"Chenxuan Wei,Jing Ouyang,Ruoer Yu,Siqin Yang,Hong Xu","doi":"10.1016/j.fertnstert.2025.04.004","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.04.004","url":null,"abstract":"OBJECTIVETo report a rare case of unicornuate uterus, whose rudimentary horn has finally developed into a diffuse adenomyosis foci, and to demonstrate a fertile preserved approach for the treatment of such a condition.DESIGNstep by step video of a rare case report SUBJECTS: A 29-year-old nulliparous patient presented with severe dysmenorrhea, menorrhagia and an infertility history for nearly 10 years. Her dysmenorrhea has been worsening in recent two years, and she has a strong desire of giving birth. The study was approved by the local ethics committee of Shanghai Jiao Tong University School of Medicine Affiliated International Peace Maternal and Child Health Hospital. The patient included in this video gave consent for publication of the video and posting of the video online including social media, the journal website, scientific literature websites (such as PubMed, ScienceDirect, Scopus, etc.) and other applicable sites.EXPOSURETransvaginal ultrasonography, magnetic resonance imaging, and laparoscopic resection of rudimentary horn with adenomyosis, endometrioma and superficial endometriosis. Chromopertubation was also performed to assess tubal competency. Laparoscopic resection was performed to relief pain and preserve fertility.MAIN OUTCOME MEASURE(S)Symptomatic relief, restoration of normal anatomy, and fertile reservation.RESULT(S)During the follow up, her dysmenorrhea resolved. Her ovarian reserve remained at 2.04 after the surgery. She was considering embryo transfer.CONCLUSION(S)We reported a rare case of unicornuate uterus with adenomyosis in the rudimentary horn, with superficial endometriosis lesions and ovarian endometrioma. While endometriosis is commonly seen in patients with uterine malformation, the development of adenomyosis is rare. The long term periodic bleeding inside the obstructive rudimentary horn with functional endometrium may help the development of adenomyosis, indicating an advanced stage of this uterine malformation. Early diagnosis of such a uterine malformation is quite necessary to prevent such severe complications. The existence of adenomyosis should be considered in infertile women with uterine malformations. The laparoscopic resection of the pathological rudimentary horn is possible after careful adhesiolysis without cutting the uterine artery to relief clinical symptoms, restore normal pelvic anatomy, and preserve future fertility.","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"14 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143851077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preimplantation Genetic Testing and Carrier Status Detection in Patients with Balanced Chromosomal Rearrangements: A Real-World Multicenter Retrospective Study.","authors":"Hao Shi,Wenbin Niu,Haiyan Bai,Li Wu,Xiao Bao,Shanjun Dai,Hui He,Yifan Zhou,Yaxin Yao,Jing Wang,Yidong Liu,Yangyun Zou,Sijia Lu,Lei Jin,Juan-Zi Shi,Yingpu Sun","doi":"10.1016/j.fertnstert.2025.04.008","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.04.008","url":null,"abstract":"OBJECTIVETo investigate the euploid rate of blastocysts in couples with balanced chromosomal rearrangements and to evaluate the accuracy of the mapping allele with resolved carrier status (MaReCs) technique in discriminating between non-carrier and carrier embryos.DESIGNMulticenter, retrospective, cohort study.SUBJECTSWe involved 2,002 couples with various types of balanced chromosomal rearrangements (reciprocal translocations, Robertsonian translocations, and inversions), who underwent in vitro fertilization (IVF) treatment between January 2017 and September 2023.EXPOSUREBlastocyst euploidy was assessed using preimplantation genetic testing for structural rearrangements (PGT-SR), and the carrier status of euploid embryos was determined using MaReCs. For the transferred euploid embryos, amniocentesis was performed at 16-20 weeks of gestation to examine fetal chromosomes. The amniocentesis results were used as the gold standard to evaluate the accuracy of the MaReCs technique.MAIN OUTCOME MEASURESThe euploid rate of blastocysts in couples with balanced chromosomal rearrangements and the accuracy of the MaReCs technique.RESULTSIn total, 13,730 embryos from 2,629 PGT-SR cycles among 2002 couples were analyzed. 64.3% (1287/2002) of couples obtained euploid embryos in the first controlled ovarian hyperstimulation (COH) cycle and the percentage was 63.5% (1,670/2,629) of all cycles. The total euploid rate of blastocysts was 24.2% (3,324/13,730). 332 couples in 360 cycles requested to distinguish the euploid embryos. A total of 1021 blastocysts were discriminated, in which 49.4% (505/1021) were non-carrier. 78.3% of patients (260/332) obtained non-carrier embryos in the first COH cycle. Follow-up data showed that among the 122 patients undergoing amniocentesis, the consistency between MaReCs and amniocentesis was 99.2% (121/122).CONCLUSIONMaReCs is a simple and precise method for distinguishing the carrier status of euploid embryos, providing a reliable solution for patients with balanced chromosomal rearrangements to stop the passing on of chromosome rearrangement to the next generation.","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"31 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143849556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Glucagon-Like Peptide 1 Agonist Medications on Weight Loss in Patients with and Without Polycystic Ovary Syndrome.","authors":"Emily Gleason,Lindsay Levine,Iris T Lee,Nathanael Koelper,Anastassia Amaro,Anuja Dokras","doi":"10.1016/j.fertnstert.2025.04.009","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.04.009","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"28 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Not All Mosaic Embryos Are the Same: Time to Refine How We Report Mosaicism in PGT.","authors":"Mili Thakur","doi":"10.1016/j.fertnstert.2025.04.007","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.04.007","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"136 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Clomiphene Citrate on Multiple Gestation Births and Perinatal Outcomes: A Nationwide Cohort Study.","authors":"Mathilde Bourdon,Pietro Santulli,Nathanaël Beeker,Mathis Collier,Jean-Marc Treluyer,Vassilis Tsatsaris,Pierre Pinson,Laurent Chouchana","doi":"10.1016/j.fertnstert.2025.04.005","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.04.005","url":null,"abstract":"OBJECTIVETo evaluate the occurrence of multiple gestation birth and perinatal adverse outcomes in pregnancies resulting from clomiphene citrate (CC) treatment compared to non-exposed pregnancies.DESIGNNationwide cohort study in an university hospital-based research center.SUBJECTSPregnancies lasting more than 22 weeks of gestation, in women aged between 18-43 years between 2013 to 2019, recorded in the French health data warehouse (SNDS).EXPOSURE(S)Pregnancies exposed to CC were assigned to a 1:5 unexposed control cohort based on maternal age, calendar year of childbirth, French social deprivation index, history of hypertension and diabetes. Exclusion criteria were IVF/ICSI treatment or gonadotrophins within 12 months before pregnancy and pregnancies occurring in women with the dispensing of CC between 12 to 2 months, and/or less 11days before the beginning of the pregnancy.MAIN OUTCOME MEASURE(S)Multiple gestation birth rate and perinatal outcomes RESULTS: Of 3,173,013 pregnancies, 32,010 (1%) occurred in women exposed to CC, of which 31,934 were assigned to 159,670 unexposed control pregnancies. The multiple pregnancy rate was significantly higher in CC-exposed pregnancies (5.2% versus 1.4%; odds ratio (OR) 3.9, 95% CI [3.7-4.1]) such as twin pregnancies ( 5.1% versus 1.4%; OR 3.9, 95% CI [3.7-4.1]) and triple or more pregnancies (0.13% versus 0.03%; OR 4.3, 95% CI [2.9-6.5]) compared to the unexposed control cohort. Women exposed to CC presented significantly more adverse obstetrical and perinatal outcomes, including stillbirths, premature delivery threats, premature rupture of membranes, gestational diabetes, placenta previa, gravid hypertension, pre-eclampsia, preterm birth, small for gestational age (SGA) and C-section rate. After stratification on multiple pregnancy and adjustment on confounders (history of psychiatric disease, obesity and embryo reduction during pregnancy), exposure to CC remains associated with adverse outcomes in both singleton and multiple pregnancies.CONCLUSIONA four-fold risk of multiple gestation births was found in pregnancies exposed to CC, along with perinatal adverse events, even in singletons. Although it remains uncertain whether these adverse events are due to the medication itself or to the treated medical condition, these findings should provide awareness of practitioners and patients about its use. It also underscores the importance of attentively monitoring follicular growth during the treatment process to avoid multiple pregnancies.","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"108 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of PGT-A on time to live birth in IVF.","authors":"Yael Eliner,Bridget Foley,Steven R Bayer,Kim L Thornton,Alan S Penzias,Denny Sakkas,Denis A Vaughan","doi":"10.1016/j.fertnstert.2025.04.006","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.04.006","url":null,"abstract":"OBJECTIVETo determine if utilizing pre-implantation genetic testing for aneuploidy (PGT-A) impacts time to pregnancy resulting in a live birth.DESIGNRetrospective cohort study.SETTINGSingle, large, university-affiliated fertility center in the United States.SUBJECTSPatients who underwent their first oocyte retrieval between January 1st, 2014, and December 31st, 2022, were included. Patients were categorized into a PGT-A group and a non-PGT-A group based on the use of PGT-A at the time of the first oocyte retrieval. Patients were then stratified by age: women <38 years old and women ≥38 years old at the time of the first retrieval. Propensity score matching was performed using nine criteria, matching 2,158 PGT-A patients to 2,158 non-PGT-A patients in the younger age group, and 1,343 PGT-A patients to 1,343 non-PGT-A patients in the older age group.EXPOSUREUse of PGT-A.MAIN OUTCOME MEASURESThe positive pregnancy rate leading to a live birth over a one-year period following the initial egg retrieval. This was used as an indicator of time to successful pregnancy.RESULTSFollowing the matching process, there were no statistically significant differences in the examined characteristics between PGT-A and non-PGT-A patients. The Kaplan-Meier curves showed that there was no significant difference in the probability of having a live birth in the younger group, with a live birth hazard ratio for the full year of 0.97 (95% CI 0.90-1.04), but was significantly shorter for PGT-A patients, with a live birth hazard ratio of 1.46 (95% CI 1.30-1.64) in the older group. Patients in the ≥38 age group who used PGT-A had a higher live birth rate over a one-year period, compared to non-PGT-A patients (51.2% versus 36.4%). In contrast, PGT-A and non-PGT-A patients in the <38 age group had similar cumulative one-year live birth rates (69.5% versus 67.1%). In both age groups, miscarriage rates and mean number of transfers were lower for PGT-A patients.CONCLUSIONPGT-A is associated with a shorter time to pregnancy resulting in a live birth for patients who are at least 38 years old but does not affect time to successful pregnancy in younger patients over a one-year period.","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"40 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reproductive Treatment in Restrictive Times: Utilization of Pre-Implantation Genetic Testing After Dobbs.","authors":"Alexandra Herweck,Heather S Hipp","doi":"10.1016/j.fertnstert.2025.04.002","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.04.002","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"33 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of stress in male infertility.","authors":"Peter N Schlegel","doi":"10.1016/j.fertnstert.2025.04.003","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.04.003","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"27 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cesarean sections: too much of a good thing?","authors":"Dominique de Ziegler, Anuja Dokras","doi":"10.1016/j.fertnstert.2025.03.004","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.03.004","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}