Fertility and sterility最新文献

{"title":"Assisted hatching decreases pregnancy outcomes in vitrified donor oocytes.","authors":"Amalia Namath, Jonathan M Konel, Jing Wu, Adina Schwartz, Wayne Caswell, Jeanne E O'Brien, Stephanie Beall","doi":"10.1016/j.fertnstert.2025.03.005","DOIUrl":"10.1016/j.fertnstert.2025.03.005","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the impact of assisted hatching on implantation and pregnancy rates among fresh embryo transfers using vitrified donor oocytes.</p><p><strong>Design: </strong>Retrospective cohort study.</p><p><strong>Subjects: </strong>Oocyte donor recipients.</p><p><strong>Exposure: </strong>Assisted hatching.</p><p><strong>Main outcome measures: </strong>Rates of implantation, clinical pregnancy, spontaneous abortion, and ongoing pregnancy.</p><p><strong>Results: </strong>Among the 2,617 embryos, 1,668 (64%) underwent assisted hatching. The biochemical pregnancy rate per transfer and clinical pregnancy rate per transfer were significantly lower for the assisted hatching group vs. non-assisted hatching group (72% vs. 76%; adjusted risk ratio (aRR), 0.94; 95% confidence interval [CI], 0.9-0.99 and 61% vs. 66%; aRR, 0.92; 95% CI, 0.86-0.97). The assisted hatching group also had a lower ongoing/sustained pregnancy rate (57% vs. 62%; aRR, 0.91; 95% CI, 0.78-0.91) compared with the non-assisted hatching group. Spontaneous abortion may be higher for the assisted hatching group compared with the non-assisted hatching group, although not statistically significant (13% vs. 11%).</p><p><strong>Conclusion: </strong>Assisted hatching may be associated with decreased clinical and ongoing pregnancy rates in donor oocyte cycles.</p>","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To rescue or not to rescue immature oocytes: Prospects and challenges.","authors":"Giovanni Coticchio, Danilo Cimadomo, Michel De Vos, Thomas Ebner, Marga Esbert, Maria Jose Escriba, Robert B Gilchrist, Laura Rienzi","doi":"10.1016/j.fertnstert.2025.02.039","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.02.039","url":null,"abstract":"<p><p>In vitro maturation (IVM) of immature oocytes has been explored for research and clinical purposes since the dawn of assisted reproduction technologies. Oocyte maturation is a highly specific process, based on complex mutual relationships between the germ and somatic cell compartments. The complexity of this relationship has made the quest for achieving oocyte maturation in vitro arduous. In its classical form, in which intact cumulus enclosed oocytes are collected without or with very mild ovarian stimulation, oocyte IVM is non-experimental and has been proposed as a more friendly treatment for PCO/PCOS patients. By contrast, rescue IVM, which is the maturation in vitro if immature oocytes collected in standard ovarian stimulation cycles, is an experimental procedure, proposed to mitigate the impact of low oocyte maturation rates in certain patients. Achieving effective rescue IVM has turned out to be an even more daunting task, as oocytes are cultured only after cumulus cell removal and therefore without the crucial somatic metabolic and regulative support. Immatures oocyte arrested at the germinal vesicle or metaphase I stage require different management for their maturation in vitro and exhibit different developmental and chromosomal competence. Therefore, their possible use for treatment suggests a personalized approach. Overall, rescue IVM has limited clinical efficacy due to suboptimal maturation and developmental competence of immature oocytes. This raises a cost/benefit question: i.e., the definition of appropriate clinical indications. Rescue IVM is probably irrelevant to treatment cycles in which the absolute number of mature oocytes is high. Conversely, specific poor prognosis cases, involving low maturation rates, low oocyte yield and/or low oocyte quality, could benefit from the contribution of even a single embryo generated from an in vitro matured oocyte. Future progress in this field will depend on our ability to mimic in vitro the support provided by cumulus cells to oocyte nuclear and cytoplasmic maturation.</p>","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to comments.","authors":"Nan Zhang, Tian Tian, Rui Yang","doi":"10.1016/j.fertnstert.2025.03.001","DOIUrl":"10.1016/j.fertnstert.2025.03.001","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing PCOS Research: Addressing Key Limitations and Future Directions.","authors":"Qian Dai, Huanyu Jiang, Jian Luo","doi":"10.1016/j.fertnstert.2025.02.038","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.02.038","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing the Endometriosis Gap and Promoting Equal Access to Care for Black Women with Endometriosis.","authors":"Janelle Jackman, Jasmine Eliwa, Gloria Richard-Davis, Kim Thornton, Zaraq Khan, Rebecca Flyckt","doi":"10.1016/j.fertnstert.2025.02.040","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.02.040","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transfer of embryos affected by monogenic conditions: an Ethics Committee Opinion.","authors":"","doi":"10.1016/j.fertnstert.2025.02.001","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.02.001","url":null,"abstract":"<p><p>Patient requests for transfer of embryos affected by monogenic conditions linked to serious health-affecting disorders detected in preimplantation testing are rare but do exist. This opinion sets out the possible rationales for a physician's decision to assist or decline to assist in such transfers. The Committee concludes that in most clinical cases, it is ethically permissible to assist or refuse to assist in transferring such embryos. However, in circumstances in which a child is highly likely to be born with a life-threatening condition that causes severe and early debility with no possibility of reasonable function, the transfer of such embryos is ethically problematic and highly discouraged.</p>","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to 'Prospective solutions to ovarian reserve damage during the ovarian tissue cryopreservation and transplantation procedure' [Fertility and Sterility 122 (2024) 565-573].","authors":"Abigail Mercier, Joshua Johnson, Amanda N Kallen","doi":"10.1016/j.fertnstert.2024.12.021","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2024.12.021","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Losing our edge: how the decline of surgery is reshaping the specialty of reproductive endocrinology and infertility.","authors":"Divya K Shah, Marcelle I Cedars, Clarisa R Gracia","doi":"10.1016/j.fertnstert.2025.02.037","DOIUrl":"10.1016/j.fertnstert.2025.02.037","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Premature ovarian insufficiency and the risk of breast cancer.","authors":"Herjan Jt Coelingh Bennink, Jan Fm Egberts, Frank Z Stanczyk","doi":"10.1016/j.fertnstert.2025.02.036","DOIUrl":"10.1016/j.fertnstert.2025.02.036","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short and long-term risks of assisted reproductive technology remain nebulous.","authors":"Amalia Namath, Kate Devine","doi":"10.1016/j.fertnstert.2025.02.034","DOIUrl":"10.1016/j.fertnstert.2025.02.034","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}