Fertility and sterility最新文献

{"title":"A cost analysis of clomiphene citrate, letrozole, and gonadotropin with intrauterine insemination using outcome data from the AMIGOS trial","authors":"Eden R. Cardozo M.D. , Ruben Alvero M.D. , Michael P. Diamond M.D. , Nanette Santoro M.D. , Brindha Bavan M.D.","doi":"10.1016/j.fertnstert.2024.10.032","DOIUrl":"10.1016/j.fertnstert.2024.10.032","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 4","pages":"Pages 721-723"},"PeriodicalIF":6.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal restoration of spermatogenesis after testosterone therapy using human chorionic gonadotropin and follicle-stimulating hormone","authors":"Blair T. Stocks M.D., Ph.D. , Amelia G. Oppenheimer B.S. , Kevin J. Campbell M.D. , John P. Lindsey M.D. , Taylor P. Kohn M.D. , Juliet M. Alexander B.S. , Jason B. Huang M.D. , Larry I. Lipshultz M.D.","doi":"10.1016/j.fertnstert.2024.10.019","DOIUrl":"10.1016/j.fertnstert.2024.10.019","url":null,"abstract":"<div><h3>Objective</h3><div>To study improvements in spermatogenesis in men with a history of testosterone therapy using a novel fertility treatment regimen.</div></div><div><h3>Design</h3><div>A single-center retrospective cohort analysis.</div></div><div><h3>Subjects</h3><div>Seventy-seven men with previous testosterone use seeking fertility treatment from January 2020 to March 2024.</div></div><div><h3>Exposure</h3><div>A treatment regimen of 3,000 IU of human chorionic gonadotropin (hCG) and 75 IU of follicle-stimulating hormone (FSH) three times a week was used.</div></div><div><h3>Main Outcome Measures</h3><div>The primary outcome measured was change in sperm concentration during hCG/FSH therapy. The secondary outcome measured was whether concurrent testosterone therapy during hCG/FSH therapy affected recovery of spermatogenesis.</div></div><div><h3>Results</h3><div>Within the entire cohort (n = 77), 74% of men demonstrated improvements in their sperm concentrations. There was not a significant difference in recovery of sperm concentration in men who stayed on testosterone therapy during hCG/FSH reboot (no testosterone therapy [n = 50], 74% improved, vs. concurrent testosterone therapy [n = 27], 74% improved).</div></div><div><h3>Conclusion</h3><div>We report optimal recovery of spermatogenesis with hCG/FSH therapy in men with infertility with a history of testosterone use. Concurrent testosterone therapy does not impede hCG/FSH-mediated spermatogenic recovery.</div></div><div><div>Restauración óptima de la espermatogénesis después del tratamiento con testosterona usando gonadotropina coriónica humana y hormona folículo estimulante</div></div><div><h3>Objetivo</h3><div>Estudiar las mejoras en la espermatogénesis en hombres con antecedentes de tratamiento con testosterona utilizando un nuevo régimen de tratamiento de fertilidad.</div></div><div><h3>Diseño</h3><div>Análisis de cohorte retrospectivo de un solo centro.</div></div><div><h3>Sujetos</h3><div>Setenta y siete hombres con uso previo de testosterona que buscaron tratamiento de fertilidad desde enero de 2020 hasta marzo de 2024.</div></div><div><h3>Exposición</h3><div>Se utilizó un régimen de tratamiento de 3000 UI de gonadotropina coriónica humana (hCG) y 75 UI de hormona folículo estimulante (FSH) tres veces por semana.</div></div><div><h3>Principales medidas de resultados</h3><div>El resultado primario medido fue el cambio en la concentración de espermatozoides durante el tratamiento con hCG/FSH. El resultado secundario medido fue si el tratamiento con testosterona concurrente durante la terapia con hCG/FSH afectó la recuperación de la espermatogénesis.</div></div><div><h3>Resultados</h3><div>En toda la cohorte (n = 77), el 74 % de los hombres demostraron mejoras en sus concentraciones de esperma. No hubo una diferencia significativa en la recuperación de la concentración de esperma en los hombres que continuaron con el tratamiento con testosterona durante el reinicio de hCG/FSH (si","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 4","pages":"Pages 607-615"},"PeriodicalIF":6.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to ‘Prevention of moderate and severe ovarian hyperstimulation syndrome: a guideline.” [Fertil Steril 2024;121:230-45]","authors":"Practice Committee of the American Society for Reproductive Medicine","doi":"10.1016/j.fertnstert.2024.10.012","DOIUrl":"10.1016/j.fertnstert.2024.10.012","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 4","pages":"Page 741"},"PeriodicalIF":6.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the back-of-the-envelope: elevating cost discourse in fertility care","authors":"Jessica R. Walter M.D., M.S.C.E","doi":"10.1016/j.fertnstert.2025.01.007","DOIUrl":"10.1016/j.fertnstert.2025.01.007","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 4","pages":"Pages 604-605"},"PeriodicalIF":6.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Key standards and principles for developing evidence-based clinical guidelines: balancing health professional, patient, funder, and government needs","authors":"Chau Thien Tay Ph.D. ,&nbsp;Anju E. Joham Ph.D. ,&nbsp;Helena J. Teede Ph.D.","doi":"10.1016/j.fertnstert.2025.01.023","DOIUrl":"10.1016/j.fertnstert.2025.01.023","url":null,"abstract":"<div><div>Clinical practice guidelines are critical tools to inform healthcare decision-making, yet development faces significant challenges in ensuring rigorous, reliable, and globally applicable recommendations. This review examines the essential standards and evolving approaches for creating high-quality, evidence-based guidelines that can effectively support clinical practice across diverse healthcare settings. Key standards for high-quality clinical practice guideline development emerge from leading global health organizations, emphasizing several critical components—establishing a multidisciplinary development group, defining a clear and relevant scope, conducting systematic evidence reviews and meta-analyses, and ensuring transparency throughout the development process. Innovative principles address emerging challenges such as research integrity assessment, incorporation of patient-centered methodologies, promotion of global collaborative approaches, and development of strategic implementation strategies. These evolving principles recognize the complex landscape of modern healthcare, where guidelines should adhere to rigorous standards to genuinely improve patient outcomes and encourage best practice care across diverse healthcare settings.</div></div>","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 4","pages":"Pages 561-568"},"PeriodicalIF":6.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing research on maternal stress and pubertal development: a call for broader considerations and interventions","authors":"Yu Feng Ph.D. ,&nbsp;Yifan Hao Ph.D. ,&nbsp;Hui Gu Ph.D.","doi":"10.1016/j.fertnstert.2024.10.022","DOIUrl":"10.1016/j.fertnstert.2024.10.022","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 4","pages":"Page 739"},"PeriodicalIF":6.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of utilization of infertility services by race and ethnicity in a state with a comprehensive infertility mandate","authors":"Ann Korkidakis M.D., M.P.H. ,&nbsp;Veronica Wang M.S. ,&nbsp;Riwa Sabbagh M.D. ,&nbsp;Quetrell Heyward M.D., M.B.A. ,&nbsp;Michele R. Hacker Sc.D., M.S.P.H. ,&nbsp;Kim L. Thornton M.D. ,&nbsp;Alan S. Penzias M.D.","doi":"10.1016/j.fertnstert.2024.10.036","DOIUrl":"10.1016/j.fertnstert.2024.10.036","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;To examine the association between sociodemographic factors and utilization of infertility services by race and ethnicity in a state with a comprehensive infertility mandate.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Design&lt;/h3&gt;&lt;div&gt;Retrospective cohort.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Exposure&lt;/h3&gt;&lt;div&gt;Initial infertility evaluation and treatment utilization.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Main Outcome Measures&lt;/h3&gt;&lt;div&gt;The prevalence of reproductive-aged women who reside in Massachusetts presenting for initial consult vs. census-based estimates was calculated for each racial and ethnic group. Age at initial consult, insurance coverage, drive time to nearest affiliated center, and neighborhood deprivation as measured by Area Deprivation Index (ADI) were considered determinants of treatment utilization in regression analysis.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;A total of 16,160 women presenting for an infertility consult from 2010–2021 met inclusion criteria. Compared with census estimates, Non-Hispanic (NH) Asian and NH White individuals were overrepresented in initial consults, whereas the NH Black and Hispanic populations were underrepresented throughout the study period. Mean age at presentation was higher in NH Black women compared with the NH Asian reference group (35.7 ± 5.1 vs. 34.6 ± 4.4 years old). A lower proportion of Hispanic and NH Black women had private insurance (78% and 79%, respectively) compared with 86% of NH Asian women. Over a fifth of Hispanic and NH Black women lived in the most disadvantaged ADI quintile (23% and 21%, respectively) compared with 6% of the reference population. Overall, the absence of private insurance, greater neighborhood disadvantage, and increased driving distance were associated with lower treatment utilization (odds ratio [OR]: 0.79 [95% confidence interval 0.71–0.87], for other vs. private insurance; OR: 0.62 [0.53–0.72], for ADI quintile 5 vs. 1, OR: 0.84 [0.72–0.97] for drive time 15–30 vs. &lt;15 minutes), whereas age was not (OR: 0.96 [0.93–1.00] for each 5-year increase).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;Relative to their numbers in the broader population of reproductive-aged women in Massachusetts, the NH Black and Hispanic populations were the most underrepresented racial and ethnic groups seen for infertility evaluation at our center. These individuals were less likely to have private insurance coverage and more likely to live in disadvantaged neighborhoods, which are variables that negatively impact infertility treatment utilization.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;div&gt;Determinantes de la utilización de servicios de infertilidad por raza y etnicidad en un estado con un mandato integral de infertilidad.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objetivo&lt;/h3&gt;&lt;div&gt;Examinar la asociación entre los factores sociodemográficos y la utilización de los servicios de infertilidad por raza y etnia en un estado con un mandato integral de infertilidad.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Diseño&lt;/h3&gt;&lt;div&gt;Cohorte retrospectiva.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Exposición&lt;/h3&gt;&lt;","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 4","pages":"Pages 709-717"},"PeriodicalIF":6.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To trigger or surge: equal outcomes in modified and true natural frozen embryo transfer cycles","authors":"Blake Vessa M.D.,&nbsp;Thomas A. Molinaro M.D., M.S.C.E.","doi":"10.1016/j.fertnstert.2025.01.018","DOIUrl":"10.1016/j.fertnstert.2025.01.018","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 4","pages":"Pages 602-603"},"PeriodicalIF":6.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracytoplasmic sperm injection alone is the most efficacious, effective, and efficient treatment for couples with male factor infertility","authors":"Marisa Gigg M.D. ,&nbsp;Richard J. Paulson M.D., M.S. ,&nbsp;Jacob A. Brems M.D. ,&nbsp;R. Matthew Coward M.D., F.A.C.S. ,&nbsp;Peter N. Schlegel M.D.","doi":"10.1016/j.fertnstert.2025.02.005","DOIUrl":"10.1016/j.fertnstert.2025.02.005","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 4","pages":"Pages 574-580"},"PeriodicalIF":6.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood adversity and risk of endometriosis, fibroids, and polycystic ovary syndrome: a systematic review","authors":"Sara L. Berndt M.Biostat.,&nbsp;Leticia Watanabe Ribeiro M.P.H.,&nbsp;Ingrid Rowlands Ph.D,&nbsp;Jenny Doust B.M.N.S., Ph.D.,&nbsp;Gita D. Mishra Ph.D.","doi":"10.1016/j.fertnstert.2024.10.048","DOIUrl":"10.1016/j.fertnstert.2024.10.048","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Importance&lt;/h3&gt;&lt;div&gt;Although childhood adversity has been extensively studied in relation to various health outcomes, investigation of its association with gynecological conditions remains limited.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;To systematically review studies examining the effect of childhood adversity on the prevalence of three gynecological conditions: endometriosis; fibroids; and polycystic ovary syndrome (PCOS) in the population.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Evidence review&lt;/h3&gt;&lt;div&gt;Six databases were searched from inception to March 12, 2024. Observational studies of women with exposure to adversity before the age of 18 and an outcome of endometriosis, fibroids, and/or PCOS were eligible for inclusion. Studies were summarized through a qualitative synthesis. We evaluated the risk of bias using the Newcastle-Ottawa Scale.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Findings&lt;/h3&gt;&lt;div&gt;Seven studies that reported on the association between a form of childhood adversity and endometriosis, fibroids, and or PCOS were selected for review. All seven studies received a moderate risk of bias score. Cumulative exposure to childhood adversity was associated with an increased risk of endometriosis and fibroids. Childhood exposure to sexual abuse was associated with an increased risk of endometriosis and fibroids. Exposure to physical abuse in childhood was associated with a greater risk of fibroids.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion and relevance&lt;/h3&gt;&lt;div&gt;A small number of studies have shown an association between childhood adversity and the development of endometriosis and fibroids in later life. These initial findings warrant further investigation in larger studies using standardized measures.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;div&gt;Adversidades infantiles y riesgo de endometriosis, fibromas y síndrome de ovario poliquístico: una revisión sistemática.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Importancia&lt;/h3&gt;&lt;div&gt;Aunque la adversidad infantil se ha estudiado ampliamente en relación con diversos resultados de salud, la investigación de su asociación con afecciones ginecológicas sigue siendo limitada.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objetivo&lt;/h3&gt;&lt;div&gt;Revisar sistemáticamente los estudios que examinan el efecto de la adversidad infantil sobre la prevalencia de tres afecciones ginecológicas: endometriosis, fibromas y síndrome de ovario poliquístico (SOP) en la población.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Revisión de la evidencia&lt;/h3&gt;&lt;div&gt;Se realizaron búsquedas en seis bases de datos desde el inicio hasta el 12 de marzo de 2024. Se incluyeron estudios observacionales de mujeres expuestas a adversidades antes de los 18 años y el resultado de endometriosis, fibromas y/o síndrome de ovario poliquístico. Los estudios se resumieron mediante una síntesis cualitativa. Evaluamos el riesgo de sesgo utilizando la escala de Newcastle-Ottawa.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Hallazgos&lt;/h3&gt;&lt;div&gt;Se seleccionaron para su revisión siete estudios que informaban sobre la asociación entre una forma de adversidad infantil y endometriosis, fibromas y síndrome de ovario pol","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 4","pages":"Pages 677-691"},"PeriodicalIF":6.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}