Fertility and sterility最新文献

{"title":"Perinatal outcomes of women with recurrent pregnancy loss undergoing frozen embryo transfer from the Society of Assisted Reproductive Technology database","authors":"Virginia-Arlene Go M.D. , Martin Goros M.S. , Byeong Yeob Choi Ph.D. , Leslie V. Farland Sc.D. , Randal D. Robinson M.D. , Winifred Mak M.D., Ph.D.","doi":"10.1016/j.fertnstert.2024.10.016","DOIUrl":"10.1016/j.fertnstert.2024.10.016","url":null,"abstract":"<div><h3>Objective</h3><div>To assess whether infants born to women with a history of recurrent pregnancy loss (RPL) have an increased risk of adverse perinatal outcomes after frozen embryo transfer (FET) compared with women without a history of infertility or RPL.</div></div><div><h3>Design</h3><div>Retrospective cohort study utilizing the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System database between 2014 and 2020.</div></div><div><h3>Subjects</h3><div>Patients in the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System database who underwent their first FET resulting in live birth either with a diagnosis of RPL (cases n = 3,299) or without a history of RPL or infertility, the comparison population being tubal ligation (TL) only (n = 1,408).</div></div><div><h3>Exposure</h3><div>Recurrent pregnancy loss.</div></div><div><h3>Main Outcome Measures</h3><div>Low birthweight (<2,500 g), additional outcomes included gestational age (continuous), birthweight (continuous), preterm delivery (<37 weeks), mode of delivery, and neonatal death, defined as death before the completion of the 28th day of life.</div></div><div><h3>Results</h3><div>We observed no statistically significant difference in low birthweight, birthweight overall, mode of delivery, or risk of neonatal death between patients with RPL compared with women with TL who underwent their first FET, resulting in live birth. Patients with history of RPL compared with TL utilizing FET were more likely to have a later gestational age at delivery. Patients with RPL were also less likely to have a preterm delivery (imputed adjusted odds ratio, 0.75; 0.64–0.89) than the patients with TL. Furthermore, performing preimplantation genetic testing for aneuploidy (PGT-A) in both patients with RPL or TL did not impact perinatal outcomes compared with patients who did not undergo PGT-A.</div></div><div><h3>Conclusion</h3><div>Patients with history of recurrent pregnancy loss do not have an increased risk of adverse perinatal outcomes when they undergo FET compared with patients without infertility or RPL. In addition, performing in vitro fertilization/PGT-A in patients with RPL does not adversely impact birth outcomes of their infants.</div></div><div><div>Resultados perinatales de mujeres con aborto de repetición sometidas a transferencia de embrión congelado según la base de datos de la Sociedad de Tecnología de Reproducción Asistida.</div></div><div><h3>Objetivo</h3><div>Evaluar si los niños nacidos de mujeres con antecedentes de pérdida recurrente del embarazo (RPL), tienen un mayor riesgo de resultados perinatales adversos tras transferencia de embriones congelados (FET) en comparación con mujeres sin antecedente de infertilidad o RPL.</div></div><div><h3>Diseño</h3><div>Estudio retrospectivo de cohorte utilizando la base de datos del Sistema de Informe de Resultados Clínicos de la Sociedad de Tecnología de Reproducción Asistida (SART) entre ","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 4","pages":"Pages 644-652"},"PeriodicalIF":6.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “The role of assisted hatching in in vitro fertilization: a guideline” [Fertil Steri 2022;117:1177-82]","authors":"Practice Committee of the American Society for Reproductive Medicine","doi":"10.1016/j.fertnstert.2024.10.034","DOIUrl":"10.1016/j.fertnstert.2024.10.034","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 4","pages":"Page 743"},"PeriodicalIF":6.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How do health professionals react to clinical guidelines? Grit to cope with unpredictable situations and limitations not addressed by guidelines","authors":"Sean Sokteang M.D. ,&nbsp;Richard S. Legro M.D. ,&nbsp;Dominique de Ziegler M.D.","doi":"10.1016/j.fertnstert.2025.01.013","DOIUrl":"10.1016/j.fertnstert.2025.01.013","url":null,"abstract":"<div><div>Assisted reproductive technology has become the primary treatment of infertility. As such, assisted reproductive technology has been regulated by certain authorities and primarily, structured by various scientific organisms through recommendations and guidelines. Yet, these have limits—the topic addressed here—and may at times need to rely on grit for managing the totally unexpected. Doctors should also cope with what is not addressed by these guidelines, including the couple’s desire for final family size.</div></div>","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 4","pages":"Pages 569-572"},"PeriodicalIF":6.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Puberty progression in girls with Turner syndrome after ovarian tissue cryopreservation","authors":"Sanne van der Coelen M.D. ,&nbsp;Sapthami Nadesapillai M.D. ,&nbsp;Ronald Peek Ph.D. ,&nbsp;Didi Braat M.D., Ph.D. ,&nbsp;Gianni Bocca M.D., Ph.D. ,&nbsp;Martijn Finken M.D., Ph.D. ,&nbsp;Sabine Hannema M.D., Ph.D. ,&nbsp;Sandra de Kort M.D., Ph.D. ,&nbsp;Theo Sas M.D., Ph.D. ,&nbsp;Saartje Straetemans M.D., Ph.D. ,&nbsp;Vera van Tellingen M.D. ,&nbsp;Annemarie Verrijn Stuart M.D., Ph.D. ,&nbsp;Kathrin Fleischer M.D., Ph.D. ,&nbsp;Janielle van der Velden M.D., Ph.D.","doi":"10.1016/j.fertnstert.2024.10.025","DOIUrl":"10.1016/j.fertnstert.2024.10.025","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;To study the impact of unilateral ovariectomy for ovarian tissue cryopreservation (OTC) on the function of the remaining ovary in girls with Turner syndrome.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Design&lt;/h3&gt;&lt;div&gt;A prospective cohort study as a follow-up of OTC in a research setting (the TurnerFertility trial, NCT03381300).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Subjects&lt;/h3&gt;&lt;div&gt;A total of 28 girls with Turner syndrome with follicles in their cryopreserved ovarian cortex tissue, aged 5–19 years. Of the 28 girls, 21 had a 45,X/46,XX mosaic karyotype; 5 had structural aberrations of the X chromosome; 1 had a 45,X monosomy; and 1 had a 45,X/47,XXX karyotype.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Interventions&lt;/h3&gt;&lt;div&gt;Girls were monitored annually after OTC for pubertal development and levels of antimüllerian hormone (AMH), follicle-stimulating hormone, luteinizing hormone, estradiol, and inhibin B.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Main Outcome Measures&lt;/h3&gt;&lt;div&gt;Thelarche, menarche, and onset of premature ovarian insufficiency.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;The girls were monitored for a median duration of 3.4 years (maximum 6.6 years). The pubertal development of five prepubertal girls is still unknown; all were aged &lt;10 years and had low gonadotropin and estradiol levels at the end of the follow-up. Seven of the eight girls of approximately pubertal age (10–12 years) experienced spontaneous thelarche, although one received medication to induce puberty. Eleven of the 14 girls between the ages of 14–17 years experienced spontaneous menarche; three other girls with thelarche still had ongoing puberty at the end of follow-up with normal gonadotropins and AMH levels above the detection limit. Approximately 6–12 months after OTC, a decline in AMH concentration was observed in 57% (16/28) of girls, followed by an increase in AMH concentration in the following years. Six of the total 28 girls started hormone replacement therapy because of symptoms of premature ovarian insufficiency, and all had AMH levels &lt;0.50 μg/L before OTC.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Pubertal development progressed after unilateral ovariectomy for OTC in most girls with Turner syndrome. Hormone replacement therapy was required within a few years for girls with unfavorable parameters before OTC, such as AMH levels &lt;0.50 μg/L. Decisions regarding OTC should be personalized, considering the girl’s preferences and specific characteristics.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Clinical Trial Registration Number&lt;/h3&gt;&lt;div&gt;NCT03381300&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;div&gt;Progresión de la pubertad en niñas con síndrome de Turner después de la criopreservación del tejido ovárico.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objetivo&lt;/h3&gt;&lt;div&gt;Estudiar el impacto de la ovariectomía unilateral para criopreservación del tejido ovárico (OTC) sobre la función del ovario remanente en niñas con síndrome de Turner.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Diseño&lt;/h3&gt;&lt;div&gt;Estudio de cohortes prospectivo como seguimiento de OTC en un entorno de investigación (ensayo TurnerFertility, NCT0338130","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 4","pages":"Pages 583-592"},"PeriodicalIF":6.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply of the Authors: “Maternal stress in pregnancy and pubertal timing in girls and boys: a cohort study”","authors":"Anne Gaml-Sørensen Ph.D. ,&nbsp;Nis Brix Ph.D. ,&nbsp;Tine Brink Henriksen Ph.D. ,&nbsp;Cecilia Høst Ramlau-Hansen Ph.D.","doi":"10.1016/j.fertnstert.2024.10.041","DOIUrl":"10.1016/j.fertnstert.2024.10.041","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 4","pages":"Page 740"},"PeriodicalIF":6.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142563657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic-assisted excision of an accessory cavitated uterine malformation with indocyanine green assessment of the uterine cavity","authors":"Kyle Fleischer M.R.C.O.G. ,&nbsp;Florence Britton M.R.C.O.G. ,&nbsp;Averyl Bachi M.R.C.O.G. ,&nbsp;Benedetto Mondelli M.R.C.O.G. ,&nbsp;Michael Adamczyk M.R.C.O.G. ,&nbsp;Priya Narayanan F.R.C.R. ,&nbsp;Shaheen Khazali M.R.C.O.G.","doi":"10.1016/j.fertnstert.2024.12.033","DOIUrl":"10.1016/j.fertnstert.2024.12.033","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;To highlight the presentation and management of a patient with dysmenorrhea caused by an accessory cavitated uterine malformation (ACUM) while also summarizing the current evidence regarding this pathology.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Design&lt;/h3&gt;&lt;div&gt;Video article demonstrating the presentation, investigations, and surgical management of patient with an ACUM.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Subjects&lt;/h3&gt;&lt;div&gt;A 22-year-old patient presenting with severe cyclical pain that was refractory to medical treatment was managed at a tertiary minimally invasive gynecology and endometriosis center. Ultrasound and magnetic resonance imaging showed radiological features consistent with ACUM. After appropriate counseling, the patient decided to proceed with surgical management.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Intervention&lt;/h3&gt;&lt;div&gt;Robotic-assisted laparoscopic excision of an ACUM. The aim was to completely excise the malformation with specific steps taken to minimize blood loss, including infiltration with vasopressin and placement of temporary vascular clips, as well as prevent entry into the uterine cavity/fallopian tube. There was an incidental finding of endometriosis, which was also excised during the procedure.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Main Outcome Measures&lt;/h3&gt;&lt;div&gt;Perioperative data, including complications, histology, and symptom change.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Complete excision of malformation with uncomplicated procedure and recovery. Histology confirmed ACUM. At follow-up, the patient had complete resolution of presenting symptoms.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;This video article highlights the presentation of patient with typical features for ACUM, as well as a reproducible technique for the surgical management of this malformation. The information can be used by other clinicians managing individuals with this rare presentation.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;div&gt;Escisión asistida por robot de una malformación uterina cavitada accesoria con evaluación de la cavidad uterina usando verde de indocianina&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objetivo&lt;/h3&gt;&lt;div&gt;Resaltar la presentación y tratamiento de una paciente con dismenorrea causada por una malformación uterina cavitada accesoria (ACUM), y al mismo tiempo, resumir la evidencia actual sobre esta patología.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Diseño&lt;/h3&gt;&lt;div&gt;Articulo en video que muestra la presentación, investigación y tratamiento quirúrgico de una paciente con ACUM.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Sujeto&lt;/h3&gt;&lt;div&gt;Una paciente de 22 años que presentaba dolor cíclico severo que era refractario a tratamiento médico fue atendida en un centro terciario de ginecología y endometriosis mínimamente invasiva. La ecografía y resonancia magnética mostraron imágenes radiológicas compatibles con ACUM. Luego de un adecuado asesoramiento, la paciente decidió proceder con el tratamiento quirúrgico.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Intervención&lt;/h3&gt;&lt;div&gt;Escisión laparoscópica de una ACUM por asistida por robot. El objetivo era extirpar por completo la malformación con pasos","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 4","pages":"Pages 730-732"},"PeriodicalIF":6.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142947154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-guided hysteroscopic uterine evacuation in cases of missed abortion","authors":"Jean Paul Rouleau M.D. ,&nbsp;Jairo Hernández Ph.D. ,&nbsp;Pablo Martín-Vasallo M.D., Ph.D. ,&nbsp;Angela Palumbo M.D., Ph.D.","doi":"10.1016/j.fertnstert.2025.01.005","DOIUrl":"10.1016/j.fertnstert.2025.01.005","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;To describe the hysteroscopic, ultrasound-guided removal of missed abortion products of conception, emphasizing identification and resection of the different layers, visualization of the embryo and yolk sac, and maternal contamination-free direct sampling of the embryo and trophoblast.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Design&lt;/h3&gt;&lt;div&gt;Illustration of a step-by-step innovative ultrasound-guided surgical technique for uterine evacuation during optically directed embryo and trophoblast biopsy.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Subjects&lt;/h3&gt;&lt;div&gt;Women with missed abortion, with or without a history of infertility or recurrent pregnancy loss. The 7 patients included in this video gave consent for publication of the video and posting of the video online including social media, the journal website, and scientific literature websites.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Exposure&lt;/h3&gt;&lt;div&gt;Missed abortion was diagnosed by transvaginal ultrasound confirming loss of fetal heartbeat. After informed consent, the patient was brought to the operating room. Under deep sedation, a 5-mm hysteroscope was inserted transcervically, and the uterine cavity was distended with normal saline (80–100 mm Hg). The implantation site was identified by direct visualization and transabdominal ultrasound. The gestational sac was opened with hysteroscopic scissors, and the extracoelomic cavity was entered. The yolk sac and embryo were visualized and evaluated. Embryo and chorionic villi sampling were performed with hysteroscopic forceps. After removal of the embryo, resection of the gestational sac was accomplished with hysteroscopic forceps and scissors.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Main Outcome Measures&lt;/h3&gt;&lt;div&gt;Step-by-step educational video.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Optically identified embryonic and trophoblastic tissue and the corresponding cytogenetic result were obtained in all cases, without maternal cell contamination. There were no intraoperative complications. Patients’ follow-up revealed no cases of retained products of conception or intrauterine adhesions. All patients who attempted pregnancy were successful, without complications.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Ultrasound-guided hysteroscopic removal of a missed abortion is noninvasive and potentially safer than conventional surgical techniques. It allows comparison of trophoblastic vs. embryo biopsy and resolution of, for example, mosaicism in placental pole preimplantation embryo biopsies. A potential disadvantage is the relative complexity of the procedure compared with routine dilation and curettage (1–5).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;div&gt;Evacuación uterina histeroscópica guiada por ultrasonido en casos de aborto no deseado.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objetivo&lt;/h3&gt;&lt;div&gt;Describir la extracción histeroscópica, guiada por ultrasonido de los productos de aborto, haciendo hincapié en la identificación y resección de las diferentes capas, la visualización del embrión y el saco vitelino y la toma de muestras directas del embrión y el trofobla","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 4","pages":"Pages 733-735"},"PeriodicalIF":6.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142988746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to monitor the efficacy of ovarian stimulation for assisted reproductive technology?","authors":"Paul Pirtea M.D. ,&nbsp;Jean Marc Ayoubi M.D. ,&nbsp;Baris Ata M.D.","doi":"10.1016/j.fertnstert.2025.01.027","DOIUrl":"10.1016/j.fertnstert.2025.01.027","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"123 4","pages":"Pages 596-597"},"PeriodicalIF":6.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic and genomic insights into male reproductive tract development.","authors":"Madison Held, Helen Castillo-Madeen, Katinka A Vigh-Conrad, Kenneth I Aston, Donald F Conrad","doi":"10.1016/j.fertnstert.2025.03.024","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.03.024","url":null,"abstract":"<p><p>Genetic and genomic analysis continues to drive important insights into male reproductive tract (MRT) development. Here, we briefly review normal MRT development, highlighting recent discoveries of cell types and cellular processes delivered by single-cell sequencing. We report a systematic review of phenotype terms and genes linked to MRT development, identifying 35 terms from the Human Phenotype Ontology associated with 269 unique genes. A parallel review of mouse data revealed differences in the phenotype terms available and the number and identity of genes linked to MRT defects, indicating opportunities for harmonization of knowledge. We used a published single-cell atlas of the developing testis to characterize the regulation of MRT genes across cell types and stages of fetal testis development. scRNA-seq data supports the conclusion that Leydig cells and Sertoli cells are the primary testicular cell types expressing MRT genes. Furthermore, we find post-conception weeks 6, 8, and 16 to be key points of upregulation of testicular MRT genes. New advances, especially in imaging and spatially resolved molecular measurements, provide exciting prospects for MRT research and diagnosis, and we expect rapid progress in coming years. Continued investigation in this space is essential to understand the genetic basis of MRT development, and how MRT defects are related to medical outcomes in adult life.</p>","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perinatal outcome risks following ART: small, but to be carefully considered.","authors":"Ettore Caroppo","doi":"10.1016/j.fertnstert.2025.03.028","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2025.03.028","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}