Fertility and sterility最新文献

{"title":"In defense of in vitro fertilization: time to get involved in state-level advocacy!","authors":"Albert L Hsu, Elizabeth J Carr, Jessie Losch, Susan Crockin, J Preston Parry","doi":"10.1016/j.fertnstert.2024.10.018","DOIUrl":"10.1016/j.fertnstert.2024.10.018","url":null,"abstract":"<p><p>We share experiences in advocating to defend in vitro fertilization (IVF) in Virginia, Missouri, and Mississippi; provide historical context on the \"Personhood\" anti-IVF movement; and discuss why \"embryo donation\" is a more accurate term than \"embryo adoption.\" Some individuals and communities have a deeply held belief that a fertilized oocyte is a very early human life, and we will likely never change their minds. In the fertility community, most providers consider embryos to be an important part of the continuum between gametes (sperm and eggs) to live birth. Embryos are neither life nor property but rather a special class of \"potential life\" deserving of particular respect. The premise of the \"Personhood\" movement is that each fertilized oocyte is already an individual living being, subject to child custody and similar legal protections. Both in nature and in the laboratory, however, only a minority of fertilized eggs result in live birth. Not all IVF embryos are of adequate quality for transfer, and most transferred embryos result in negative pregnancy test results or miscarriages and, rarely, ectopic pregnancies. \"Personhood\" bills would also criminalize the life-saving, appropriate standard-of-care management of ectopic pregnancies, the most common cause of first-trimester maternal mortality. Efforts to apply a religious and moral lens to regulate and interfere with the practice of IVF on the basis of a mistaken perception that all fertilized eggs are early human beings, would make standard-of-care IVF practice impossible. By equating all fertilized eggs with live-born children, the broadly worded measures in \"Personhood\" bills would consign fertility patients to less effective treatments. As a practical matter, \"Personhood\" bills simply cannot coexist with legislation to protect the practice of IVF, without inordinate risks to physicians, their practices, and their patients. In response to recent events, the investigators encourage all readers to consider participating in state-level advocacy. Sharing IVF experiences and clinical expertise with state legislators (and other officials) can help protect patients, their providers, and the families that they strive to create. Efforts to inappropriately regulate and restrict IVF will decrease access to care to essential family-building treatments and services.</p>","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":"977-982"},"PeriodicalIF":6.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addition of operative hysteroscopy to vacuum aspiration for the management of early pregnancy loss after in vitro fertilization.","authors":"Kai-Lun Hu, Jie Zhao, Mingmei Lin, Xiaoye Wang, Linjing Qi, Huan Liu, Dan Mo, Zhonghong Zeng, Ben W Mol, Rong Li","doi":"10.1016/j.fertnstert.2024.07.027","DOIUrl":"10.1016/j.fertnstert.2024.07.027","url":null,"abstract":"<p><strong>Objective: </strong>To investigate whether operative hysteroscopy in addition to vacuum aspiration for the management of early pregnancy loss effectively increases the success rate of subsequent frozen embryo transfer.</p><p><strong>Design: </strong>Propensity score-matched cohort study.</p><p><strong>Setting: </strong>Academic hospital.</p><p><strong>Patient(s): </strong>Women with a miscarriage at 5-16 gestational weeks during an in vitro fertilization cycle in Peking University Third Hospital from 2015 to 2022.</p><p><strong>Intervention(s): </strong>Hysteroscopy plus vacuum aspiration vs. conventional vacuum aspiration.</p><p><strong>Main outcome measure(s): </strong>Live birth rate in the subsequent frozen embryo transfer.</p><p><strong>Result(s): </strong>A total of 347 women who underwent vacuum aspiration plus hysteroscopy and 2,562 women who underwent conventional vacuum aspiration were included in the analysis. After propensity score matching (1:1 ratio), 325 women were included in each group. Compared with women who underwent vacuum aspiration, those who underwent vacuum aspiration plus hysteroscopy were associated with a lower rate of live birth in the propensity score-based matched cohort (22% vs. 30%; adjusted odds ratio, 0.68 [0.47-0.97]). Biochemical, clinical, and multiple pregnancy rates were not significantly different, as was the miscarriage rate. In the overall cohort, 11 women experienced surgery reintervention in the vacuum aspiration group (0.4%), whereas none required surgery reintervention in the vacuum aspiration plus hysteroscopy group.</p><p><strong>Conclusion(s): </strong>Women who underwent vacuum aspiration plus hysteroscopy may be associated with lower rates of live birth than those who underwent vacuum aspiration. Further studies are necessary to establish this relationship definitively.</p>","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":"1134-1143"},"PeriodicalIF":6.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is the rarity of recurrent implantation failure real or a mirage?","authors":"Ryszard J Chetkowski","doi":"10.1016/j.fertnstert.2024.07.039","DOIUrl":"10.1016/j.fertnstert.2024.07.039","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":"1162"},"PeriodicalIF":6.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141878561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply of the authors: no association between celiac disease and female infertility: evidence from Mendelian randomization analysis.","authors":"Shuai Yuan, Jonas F Ludvigsson","doi":"10.1016/j.fertnstert.2024.08.320","DOIUrl":"10.1016/j.fertnstert.2024.08.320","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":"1166"},"PeriodicalIF":6.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"It takes a team to achieve success with neovagina creation.","authors":"Beth W Rackow","doi":"10.1016/j.fertnstert.2024.09.049","DOIUrl":"10.1016/j.fertnstert.2024.09.049","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":"1024-1025"},"PeriodicalIF":6.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to 'Prevention of moderate and severe ovarian hyperstimulation syndrome: a guideline.\" Fertil Steril 2024;121:230-245.","authors":"","doi":"10.1016/j.fertnstert.2024.10.012","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2024.10.012","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal cell-free DNA screening for chromosomal aneuploidies after euploid embryo transfer shows high concordance with preimplantation genetic testing for aneuploidy results and low positive predictive values.","authors":"Mitko Madjunkov, Prati Sharma, Ari Baratz, Karen Glass, Rina Abramov, Nicole Logan, Svetlana Madjunkova, Clifford Librach","doi":"10.1016/j.fertnstert.2024.07.029","DOIUrl":"10.1016/j.fertnstert.2024.07.029","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To evaluate the positive predictive value (PPV) of prenatal cell-free DNA (cfDNA) screening for chromosomal aneuploidies in pregnancies achieved either after single euploid transfer in in vitro fertilization or Preimplantation Genetic Testing for Aneuploidy (PGT-A) cycles or transfer of single untested embryo, and to assess the concordance of prenatal-cfDNA-screening and PGT-A results.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Design: &lt;/strong&gt;Single center retrospective cohort study.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Setting: &lt;/strong&gt;Fertility clinic.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Patient(s): &lt;/strong&gt;A total of 2,973 prenatal-cfDNA-screening results for the most common trisomies (T13, T18, T21, X, and Y) and microdeletions (1p36, 4p16.3, 5p15.2, 15q11.2, and 22q11.2) from singleton pregnancies allocated into two groups: PGT-A group (n = 1,204) pregnant after single euploid transfer and non-PGT-A group (n = 1769) pregnant after transfer of single untested embryo, between 2016 and 2023.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Intervention(s): &lt;/strong&gt;Not applicable.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Main outcome measure(s): &lt;/strong&gt;The primary outcome measure was the accuracy of prenatal-cfDNA screening. Positive and negative prenatal-cfDNA-screening results and subsequent prenatal or postnatal diagnostic testing were used to classify each positive prenatal-cfDNA-screening result as a true or a false positive. Secondary endpoints were to evaluate the concordance of PGT-A and prenatal-cfDNA-screening results and to assess the differences in the fetal fraction of cfDNA used for prenatal-cfDNA-screening reports between the study groups.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Result(s): &lt;/strong&gt;Prenatal-cfDNA screening was performed at a mean 11.3 ± 1.8 weeks gestational age, and yielded results in 99.9% of the patients (0.1% cancellation rate). There was no difference in the fetal fraction between PGT-A tested and not tested pregnancies (9.5% ± 4% vs. 10.3% ± 4%). 13 positive prenatal-cfDNA-screening results (two T21, two X0, four XXX, one XYY, one indeterminate sex, two 22q11 del/dup, and one 15q11.2del) were received for PGT-A group. Only one (22q11 dup) was confirmed with amniocentesis and fetal autopsy, giving a PPV for an abnormal prenatal-cfDNA screening of 7.7%, the rest had results concordant with PGT-A. Sex chromosomes were 100% concordant between prenatal-cfDNA-screening and PGT-A results, giving a 100% PPV for PGT-A for sex chromosomes and 100% negative predictive value for aneuploidies. Positive prenatal-cfDNA-screening results were received for 27 pregnancies from untested embryos (1.5%), follow-up testing was electively performed for 21, and 8 had confirmed the prenatal-cfDNA-screening result, giving a PPV for the non-PGT-A group of 38%.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion(s): &lt;/strong&gt;This study demonstrates that patients undergoing in vitro fertilization/PGT-A and single euploid embryo transfer can reliably do prenatal-cfDNA screening during their first trimester. Fetal fraction in singleton pregnancies after PGT-A tested embryos is not diffe","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":"1105-1113"},"PeriodicalIF":6.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing women's health management for predicting miscarriage risk: a call for broader inclusivity and holistic approaches.","authors":"Luyang Su, Weilan Liu, Cuiqiao Meng","doi":"10.1016/j.fertnstert.2024.07.038","DOIUrl":"10.1016/j.fertnstert.2024.07.038","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":"1160"},"PeriodicalIF":6.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141878560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refining insights on celiac disease and female infertility.","authors":"Qing Zhou","doi":"10.1016/j.fertnstert.2024.08.310","DOIUrl":"10.1016/j.fertnstert.2024.08.310","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":"1165"},"PeriodicalIF":6.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply of the authors: Assessing the impact of PCOS on pregnancy complications in FET cycles: unexplored factors and clinical implications.","authors":"Reweiguli Aihaiti, Zhihong Niu","doi":"10.1016/j.fertnstert.2024.08.343","DOIUrl":"10.1016/j.fertnstert.2024.08.343","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":"1168"},"PeriodicalIF":6.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}