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Prayers for Sickness: What do people pray for and how do they deal with unanswered prayer? 为疾病祷告:人们为什么祷告,他们如何处理未蒙应允的祷告?
F1000Research Pub Date : 2024-09-02 eCollection Date: 2024-01-01 DOI: 10.12688/f1000research.145194.2
Simon Dein, Candy Gunther Brown
{"title":"Prayers for Sickness: What do people pray for and how do they deal with unanswered prayer?","authors":"Simon Dein, Candy Gunther Brown","doi":"10.12688/f1000research.145194.2","DOIUrl":"10.12688/f1000research.145194.2","url":null,"abstract":"<p><strong>Background: </strong>This paper focuses upon prayer for sickness. What do individuals suffering from illness, their families and the wider community pray for? How do they deal with unanswered prayer? Do they pray for cure, to guide medical professionals or to cope with their sickness? What rationalisations do they proffer for unanswered prayer?</p><p><strong>Methods: </strong>Based on a critical literature review and deploying secondary data from the Twenty First Century Evangelical research programme, the data suggest that prayers for guiding medical professionals and coping are more common than for cure, at least in Global North countries such as the UK and US. But why do those who believe in miracles not ask God for divine healing? Furthermore, unanswered prayer can conflict with Christian views of God as omnipotent and all loving.</p><p><strong>Results: </strong>Respondents use a number of theodical rationalisations to resolve this conflict.</p><p><strong>Conclusions: </strong>The results are discussed in relation to cognitive dissonance theory, learned helplessness, the need to conserve a relationship with the Divine, and desire to manage risk of disappointment and reduce consequent emotional pain.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11456154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case Report: Acute large bowel obstruction with actinomycosis of the sigmoid colon mimicking neoplasm. 病例报告:急性大肠梗阻伴乙状结肠放线菌病(模仿肿瘤)。
F1000Research Pub Date : 2024-08-29 eCollection Date: 2024-01-01 DOI: 10.12688/f1000research.151907.2
Mohamed Hajri, Rami Zouari, Ines Mallek, Dhouha Bacha, Rached Bayar, Sana Ben Slama
{"title":"Case Report: Acute large bowel obstruction with actinomycosis of the sigmoid colon mimicking neoplasm.","authors":"Mohamed Hajri, Rami Zouari, Ines Mallek, Dhouha Bacha, Rached Bayar, Sana Ben Slama","doi":"10.12688/f1000research.151907.2","DOIUrl":"https://doi.org/10.12688/f1000research.151907.2","url":null,"abstract":"<p><strong>Introduction: </strong>Actinomycosis is an uncommon inflammatory bacterial disease caused by Actinomyces species, especially Actinomyces Israeli. Abdominopelvic forms are relatively rare and may involve the colon as a solid mass, mimicking a malignant tumor.</p><p><strong>Case presentation: </strong>A 68-year-old Tunisian man, with a history of diabetes, hypertension, penicillin allergy, and renal failure, presented to the emergency department with abdominal pain, vomiting, and bowel obstruction. CT scan showed an acute intestinal obstruction upstream with obstructive tissular mass at the sigmoid colon. Emergency surgery revealed a sigmoid mass and a pre-perforative cecum. Total colectomy was performed, with ileostomy and distal end closure. Histological examination confirmed Actinomyces infection. The patient was then placed on long-term doxycycline and Bactrim, with no recurrence over a 9-month follow-up period.</p><p><strong>Conclusion: </strong>Abdominal actinomycosis, though rare, presents diagnostic challenges. It can be mistaken for malignancy, leading to unnecessary surgery in non-complicated cases, since it is effectively treated by antibiotics. In complicated cases, a combined approach involving both surgery and antibiotic therapy is necessary until the infection is completely eradicated.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11393526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the Potential for Tuition-Free Higher Education in South Africa: A Scoping Review. 探索南非高等教育免学费的潜力:A Scoping Review.
F1000Research Pub Date : 2024-08-29 eCollection Date: 2024-01-01 DOI: 10.12688/f1000research.150265.2
Tlotlo Ramasu, Grace Kanakana-Katumba
{"title":"Exploring the Potential for Tuition-Free Higher Education in South Africa: A Scoping Review.","authors":"Tlotlo Ramasu, Grace Kanakana-Katumba","doi":"10.12688/f1000research.150265.2","DOIUrl":"https://doi.org/10.12688/f1000research.150265.2","url":null,"abstract":"<p><p>The debate on tuition-free higher education has raged in South Africa since the #FeesMustFall protests at South African universities in 2015 and 2016. The government responded with a tuition-free education policy targeting students from households earning less than R350 000. However, the question remains can South Africa sustain a tuition-free education policy given its developing nation status and the levels of its GDP? This article sought to assess the feasibility of tuition-free higher education for all in South Africa. A scoping review was used, and fifteen articles about tuition-free higher education feasibility in South Africa were reviewed. The choice of the scoping review was due to the need for an understanding of the current state of play in research on the feasibility of tuition-free higher education in South Africa. The results suggest that tuition-free higher education for all is not feasible in South Africa. There seems to be a consensus that South Africa lacks the resources to finance tuition-free higher education for all. Tuition-free higher education is also viewed as a regressive tax on the poor given that the majority of students in higher education institutions come from middle and upper-income households. However, it is important to note that a distinction is drawn between tuition-free higher education for all and tuition-free higher education for the poor and academically deserving. The latter seems to receive support with some viewing it as a moral imperative in an unequal society such as South Africa's. It is recommended that future studies approach the issue from an empirical standpoint whereby the GDP levels are assessed against higher education funding.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11459122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142389171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors affecting community ambulation post-stroke: a mapping review protocol. 影响中风后社区行走的因素:绘图审查协议。
F1000Research Pub Date : 2024-08-29 eCollection Date: 2024-01-01 DOI: 10.12688/f1000research.144582.2
Kanika Bansal, Jane Morgan-Daniel, Sudeshna A Chatterjee, Dorian K Rose
{"title":"Factors affecting community ambulation post-stroke: a mapping review protocol.","authors":"Kanika Bansal, Jane Morgan-Daniel, Sudeshna A Chatterjee, Dorian K Rose","doi":"10.12688/f1000research.144582.2","DOIUrl":"10.12688/f1000research.144582.2","url":null,"abstract":"<p><strong>Background: </strong>Most stroke survivors consider community ambulation an essential but unmet goal of their recovery. Historically, interventions to enhance community ambulation have focused on improving biomechanical impairments of gait; however, recent evidence suggests that biopsychosocial and environmental factors may impact community ambulation, even beyond more obvious physical impairments. The identification of factors that pose as significant facilitators or barriers to community ambulation may serve to guide stakeholders in designing relevant and evidence-based interventions for improving community ambulation post-stroke.</p><p><strong>Objective: </strong>This review aims to map the type and extent of existing evidence on the physical, biopsychosocial, and environmental factors affecting community ambulation post-stroke. Additionally, this review will describe the various methods used to examine the extent to which stroke survivors are restricted to community ambulation.</p><p><strong>Methods: </strong>Nine databases will be searched including CINAHL, PubMed, and Web of Science. We will include studies published in English during or after 2001. Studies that examine physical, biopsychosocial, and/or environmental factors affecting community ambulation in ambulatory adults at least six months post-stroke will be considered for inclusion. Studies that assess general physical activity or community mobility through transportation modes other than walking will be excluded. All identified records will be collated in citation management software, followed by steps of deduplication, title/abstract screening, and full-text reviews by at least two independent reviewers. The bibliographies of the extracted studies will also be reviewed for relevant articles. The extracted studies will be analyzed, critically appraised, and presented in tabular, narrative, and evidence map formats.</p><p><strong>Discussion: </strong>The evidence gained will be used to build a framework for community ambulation, informing stakeholders to develop meaningful interventions to improve community ambulation. The mapped evidence will motivate future studies to develop holistic approaches that specifically focus on the most vital factors that influence post-stroke community ambulation.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11364963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Poweromin X Ten, a polyherbal formulation improves male sexual function: In vivo and network pharmacology study. Poweromin X Ten,一种改善男性性功能的多草药配方:体内和网络药理学研究。
F1000Research Pub Date : 2024-08-28 eCollection Date: 2024-01-01 DOI: 10.12688/f1000research.145889.2
Sree Lalitha Bojja, Kiran Kumar Kolathur, Bhim Bahadur Chaudhari, Gangadhar Hari, Bharath Harohalli Byregowda, Sai Teja Meka, Esekia Raja Selvan, Sudheer Moorkoth, Nitesh Kumar, Anoop Austin, C Mallikarjuna Rao
{"title":"Poweromin X Ten, a polyherbal formulation improves male sexual function: <i>In vivo</i> and network pharmacology study.","authors":"Sree Lalitha Bojja, Kiran Kumar Kolathur, Bhim Bahadur Chaudhari, Gangadhar Hari, Bharath Harohalli Byregowda, Sai Teja Meka, Esekia Raja Selvan, Sudheer Moorkoth, Nitesh Kumar, Anoop Austin, C Mallikarjuna Rao","doi":"10.12688/f1000research.145889.2","DOIUrl":"10.12688/f1000research.145889.2","url":null,"abstract":"<p><strong>Introduction: </strong>Poweromin X Ten (PXT) is a polyherbal formulation, traditionally used to enhance male sexual function. However, the safety and benefits of PXT have not been scientifically evaluated. Therefore, the present study investigated the toxicity and aphrodisiac potential of PXT in male rats and explored its principal mechanisms of action.</p><p><strong>Methods: </strong>Male Wistar rats were orally administered PXT (50 or 100 mg/kg) for 28 days, and sexual activity parameters, including latency and frequency of mounting and intromissions, were studied. The reproductive toxicity and spermatogenic potential were also examined. Furthermore, dopamine and serotonin levels in brain regions associated with sexual activity were assessed. Network analysis was used to identify the key bioactive compounds and their core targets involved in their beneficial actions.</p><p><strong>Results: </strong>Treatment with PXT improved sexual activity in male rats, as evidenced by reduced mounting and intromission latency and a significant increase in mount frequency. Moreover, PXT exhibited spermatogenic potential and did not induce reproductive toxicity. Notably, treatment with 50 mg/kg PXT elevated dopamine levels in median preoptic area and hypothalamus. Pathway analysis indicated that PXT primarily modulated the PI3K-Akt, calcium, and MAPK signalling pathways to enhance male sexual function. Network analysis identified macelignan, β-estradiol, testosterone, and paniculatine as key bioactive components of PXT, which likely act through core targets, such as androgen receptor (AR), Mitogen-activated protein kinase 3 (MAPK3), epidermal growth factor receptor (EGFR), estrogen receptor 1 (ESR1), and vascular endothelial growth factor (VEGF) to facilitate the improvement of male sexual function.</p><p><strong>Conclusion: </strong>Study results suggest that PXT is a safer alternative with aphrodisiac and spermatogenic potential. These effects are partly attributed to the enhanced dopamine levels in the brain. Furthermore, this study provides insights into the specific signalling pathways and bioactive compounds that underlie the improvements in male sexual function associated with PXT.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11362716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of centralised and decentralised models of care during the 2020 Ebola Virus Disease outbreak in Equateur Province, Democratic Republic of the Congo: A brief report. 对 2020 年刚果民主共和国赤道省爆发埃博拉病毒疾病期间集中和分散护理模式的评估:简要报告。
F1000Research Pub Date : 2024-08-28 eCollection Date: 2024-01-01 DOI: 10.12688/f1000research.150755.2
Emmanuel Lampaert, Justus Nsio Mbeta, Divya Nair, Maria Mashako, Anja De Weggheleire, Armand Sprecher, Rebecca M Coulborn, Steve Ahuka-Mundeke
{"title":"Evaluation of centralised and decentralised models of care during the 2020 Ebola Virus Disease outbreak in Equateur Province, Democratic Republic of the Congo: A brief report.","authors":"Emmanuel Lampaert, Justus Nsio Mbeta, Divya Nair, Maria Mashako, Anja De Weggheleire, Armand Sprecher, Rebecca M Coulborn, Steve Ahuka-Mundeke","doi":"10.12688/f1000research.150755.2","DOIUrl":"https://doi.org/10.12688/f1000research.150755.2","url":null,"abstract":"<p><strong>Background: </strong>Traditionally in the Democratic Republic of the Congo (DRC), centralised Ebola treatment centres (ETCs) have been set exclusively for Ebola virus disease (EVD) case management during outbreaks. During the 2020 EVD outbreak in DRC's Equateur Province, existing health centres were equipped as decentralised treatment centres (DTC) to improve access for patients with suspected EVD. Between ETCs and DTCs, we compared the time from symptom onset to admission and diagnosis among patients with suspected EVD.</p><p><strong>Methods: </strong>This was a cohort study based on analysis of a line-list containing demographic and clinical information of patients with suspected EVD admitted to any EVD health facility during the outbreak.</p><p><strong>Results: </strong>Of 2359 patients with suspected EVD, 363 (15%) were first admitted to a DTC. Of 1996 EVD-suspected patients initially admitted to an ETC, 72 (4%) were confirmed as EVD-positive. Of 363 EVD-suspected patients initially admitted to a DTC, 6 (2%) were confirmed and managed as EVD-positive in the DTC. Among all EVD-suspected patients, the median (interquartile range) duration between symptom onset and admission was 2 (1-4) days in a DTC compared to 4 (2-7) days in an ETC (p<0.001). Similarly, time from symptom onset to admission was significantly shorter among EVD-suspected patients ultimately diagnosed as EVD-negative.</p><p><strong>Conclusions: </strong>Since <5% of the EVD-suspected patients admitted were eventually diagnosed with EVD, there is a need for better screening to optimise resource utilization and outbreak control. Only one in seven EVD-suspected patients were admitted to a DTC first, as the DTCs were piloted in a limited and phased manner. However, there is a case to be made for considering decentralized care especially in remote and hard-to-reach areas in places like the DRC to facilitate early access to care, contain viral shedding by patients with EVD and ensure no disrupted provision of non-EVD services.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11406140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Association between Early-Onset Pancreatic Ductal Adenocarcinoma and Patients Survival: A Systematic Review and Meta-Analysis. 早期发病的胰腺导管腺癌与患者生存率之间的关系:系统回顾与元分析
F1000Research Pub Date : 2024-08-28 eCollection Date: 2024-01-01 DOI: 10.12688/f1000research.153743.1
Kaka Renaldi, Andy William
{"title":"The Association between Early-Onset Pancreatic Ductal Adenocarcinoma and Patients Survival: A Systematic Review and Meta-Analysis.","authors":"Kaka Renaldi, Andy William","doi":"10.12688/f1000research.153743.1","DOIUrl":"10.12688/f1000research.153743.1","url":null,"abstract":"<p><strong>Background: </strong>In recent years, the incidence of early-onset pancreatic cancer (EOPC) has increased. Several studies comparing the survival of patients with EOPC to those with average-onset pancreatic cancer (AOPC) have reported mixed results. We aimed, therefore, to perform a meta-analysis summarizing the current evidence.</p><p><strong>Methods: </strong>We searched the MEDLINE and EMBASE databases for relevant articles published through March 2024. Articles comparing the survival of patients with EOPC - defined as pancreatic ductal adenocarcinoma (PDAC) diagnosed at ≤ 50 years of age - and AOPC were included in the present meta-analysis. The primary outcome was the pooled adjusted hazard ratio (aHR), and the risk of bias analysis was performed using the Quality in Prognostic Factor Studies tool. The meta-analysis was performed using a random-effects model.</p><p><strong>Results: </strong>A total of 17 studies were eligible for the primary analysis, the results of which indicated that patients with EOPC had a longer overall survival than those with AOPC (aHR = 0.80; 95% confidence interval [CI], 0.74-0.86; <i>P</i> < 0.001). The rate of distant metastasis was higher in EOPC than AOPC; however, patients with EOPC also received more treatments than those with AOPC.</p><p><strong>Conclusions: </strong>Patients with EOPC had a better prognosis than those with AOPC. Clinicians must ensure that patients with PDAC receive early and appropriate treatment to improve their survival.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11443187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142361383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Zoom fatigue related to online learning among medical students in Thailand:  Prevalence, predictors, and association with depression. 泰国医科学生与在线学习有关的变焦疲劳: 患病率、预测因素以及与抑郁症的关联。
F1000Research Pub Date : 2024-08-27 eCollection Date: 2024-01-01 DOI: 10.12688/f1000research.146084.2
Veevarin Charoenporn, Sirashat Hanvivattanakul, Kanathip Jongmekwamsuk, Rinradee Lenavat, Korravit Hanvivattanakul, Thammanard Charernboon
{"title":"Zoom fatigue related to online learning among medical students in Thailand:  Prevalence, predictors, and association with depression.","authors":"Veevarin Charoenporn, Sirashat Hanvivattanakul, Kanathip Jongmekwamsuk, Rinradee Lenavat, Korravit Hanvivattanakul, Thammanard Charernboon","doi":"10.12688/f1000research.146084.2","DOIUrl":"10.12688/f1000research.146084.2","url":null,"abstract":"<p><strong>Background: </strong>Amidst the COVID-19 pandemic, the learning pattern of medical students shifted from onsite to online. This transition may contribute to what has been called \"Zoom fatigue.\" This study aimed to evaluate the prevalence of Zoom fatigue related to online learning, identify associated factors of Zoom fatigue, and explore its correlation with depression among medical students during the COVID-19 pandemic.</p><p><strong>Methods: </strong>This cross-sectional study was conducted among 1st to 6th-year Thai medical students. The online survey was administered using a demographic and health behavior questionnaire, the Patient Health Questionnaire-9 (PHQ-9), and the Thai version of the Zoom Exhaustion & Fatigue Scale (ZEF-T).</p><p><strong>Results: </strong>Among the 386 participating students, 221 (57%) were female, with a mean age of 20.6 years. The prevalence of high Zoom fatigue was 9.6%. In the multivariable regression analysis, a lower academic year and a higher number of online learning sessions were significant predictors of Zoom fatigue (p < 0.001), while regular exercise emerged as a protective factor (p = 0.009). The prevalence of depressive disorder was 61.9%, and a significant correlation was found between having a depressive disorder and experiencing Zoom fatigue (p = 0.004).</p><p><strong>Conclusion: </strong>Zoom fatigue among medical students was correlated with depression. Consequently, medical students experiencing Zoom fatigue should undergo further assessment for depression. It is crucial to closely monitor medical students in lower academic years with a high number of online sessions for signs of Zoom fatigue. Additionally, implementing strategies, such as reducing the frequency of online sessions and promoting regular exercise, may help alleviate the symptoms.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11364962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A reference genome, mitochondrial genome and associated transcriptomes for the critically endangered swift parrot ( Lathamus discolor). 极度濒危燕鹦鹉(Lathamus discolor)的参考基因组、线粒体基因组和相关转录组。
F1000Research Pub Date : 2024-08-27 eCollection Date: 2024-01-01 DOI: 10.12688/f1000research.144352.2
Luke W Silver, Dejan Stojanovic, Katherine A Farquharson, Lauren Alexander, Emma Peel, Katherine Belov, Carolyn J Hogg
{"title":"A reference genome, mitochondrial genome and associated transcriptomes for the critically endangered swift parrot ( <i>Lathamus discolor</i>).","authors":"Luke W Silver, Dejan Stojanovic, Katherine A Farquharson, Lauren Alexander, Emma Peel, Katherine Belov, Carolyn J Hogg","doi":"10.12688/f1000research.144352.2","DOIUrl":"https://doi.org/10.12688/f1000research.144352.2","url":null,"abstract":"<p><p>The swift parrot ( <i>Lathamus discolor</i>) is a Critically Endangered migratory parrot that breeds in Tasmania and winters on the Australian mainland. Here we provide a reference genome assembly for the swift parrot. We sequence PacBio HiFi reads to create a high-quality reference assembly and identify a complete mitochondrial sequence. We also generate a reference transcriptome from five organs to inform genome annotation. The genome was 1.24 Gb in length and consisted of 847 contigs with a contig N50 of 18.97 Gb and L50 of 20 contigs. This study provides an annotated reference assembly and transcriptomic resources for the swift parrot to assist in future conservation genomic research.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11411239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Views and practices on medical cannabis of unlicensed providers in Thailand: a qualitative study. 泰国无证提供者对医用大麻的看法和做法:一项定性研究。
F1000Research Pub Date : 2024-08-27 eCollection Date: 2022-01-01 DOI: 10.12688/f1000research.110367.3
Sawitri Assanangkornchai, Darika Saingam, Kanittha Thaikla, Muhammadfahmee Talek
{"title":"Views and practices on medical cannabis of unlicensed providers in Thailand: a qualitative study.","authors":"Sawitri Assanangkornchai, Darika Saingam, Kanittha Thaikla, Muhammadfahmee Talek","doi":"10.12688/f1000research.110367.3","DOIUrl":"10.12688/f1000research.110367.3","url":null,"abstract":"<p><strong>Background: </strong>Despite the legalization of cannabis use for medical purposes in Thailand in February 2019, illicit providers are still widespread and accessible. This study aimed to understand why people still chose to receive medical cannabis treatment or products from unlicensed or illegal providers. The practices of unlicensed or illegal providers in provision of medical cannabis products or treatment services were also examined.</p><p><strong>Methods: </strong>Qualitative in-depth interviews were conducted among medical cannabis providers and users, including 36 unlicensed and 7 licensed providers and 25 users in 2019-2021. Snowball sampling was used to recruit participants until saturation of data was achieved. Interviews included open-ended questions about the providers' practices and attitudes towards medical cannabis. Interviews were recorded and transcribed, and thematic analysis was performed.</p><p><strong>Results: </strong>Overall, six reasons were identified to answer why unlicensed/illicit providers were still popular, including: 1) easy accessibility; 2) familiarity with the unlicensed providers before the legal scheme became available; 3) favorable characters (kind, supportive, non-judgmental) of unlicensed providers; 4) affordable treatment fees; 5) trust in the quality of the medicines; and 6) lack of knowledge and negative attitudes towards cannabis from healthcare professionals. Most providers started their career as medical cannabis providers by using it themselves or with their relatives and being satisfied with the results. They used cannabis products to treat all diseases, including skin, eyes, HIV/AIDS, non-communicable diseases and all kinds of cancers. Additionally, they believed that it was effective, with no or minimal adverse effects.</p><p><strong>Conclusions: </strong>This study suggests that some patients will continue receiving medical cannabis treatment and products from unlicensed or illegal providers. More attention should be paid on increasing the capacity of medical cannabis service systems within public health hospitals, and the certification of unlicensed providers, so as to integrate them into a regulated system.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11362744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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