F1000Research最新文献

{"title":"Exploring the relationship between macroeconomic indicators and sectoral indices of Indian stock market.","authors":"Sanjay Singh Chauhan, Pradeep Suri, Bhekisipho Twala, Neeraj Priyadarshi, Farman Ali","doi":"10.12688/f1000research.160668.2","DOIUrl":"https://doi.org/10.12688/f1000research.160668.2","url":null,"abstract":"<p><strong>Background of the study: </strong>The influence of macroeconomic indicators makes it important to study the relationship between macroeconomic indicators and stock market return. On further analysis it can be observed that different sectors respond differently to change in the macroeconomic indicator that is important for investors, researchers and policy makers.</p><p><strong>Methods: </strong>The autoregressive distributed lag (ARDL) model is applied to study influence of macroeconomic indicators on sectoral return of NSE from April 2012 to August 2024.</p><p><strong>Results: </strong>Findings of the study show that macroeconomic indicators influence sectoral return in the short run as well as long run and the influence is differential. The analysis of long run relationship shows that Foreign Institutional Investment (FII) significantly affects all the sectoral indices except IT. Index of industrial production (IIP) have significant relationship with Auto, IT, Media, Metal and Pharma. Money supply (MS) significantly affects Bank, FMCG and IT in the long run. Wholesale Price Index (WPI) has significant relationship with Auto, FMCG and Media in the long run. Economic Policy Uncertainty Index (EPU) affects Auto, FMCG and Pharma in the long run. Crude oil price (COP) has significant effect only on Media in the long run. Exchange rate (ER) does not have significant effect on any of the sectoral index.</p><p><strong>Conclusion: </strong>In the long run FII, IIP, EPU, MS and WIP are major determinants of stock market return. In the short run FII, ER and COP are major determinants of stock market return.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"180"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lived experiences of women who survived from pre-eclampsia and eclampsia in public hospitals of Shashemene Town, Oromia Region, Ethiopia: a qualitative study.","authors":"Negeso Gebeyehu, Aman Urgessa, Daniel Yohannes, Aster Yalew, Muluneh Ahmed, Meron Admasu","doi":"10.12688/f1000research.129648.3","DOIUrl":"10.12688/f1000research.129648.3","url":null,"abstract":"<p><strong>Objective: </strong>The main purpose of this study was to explore experiences of women who survived pre-eclampsia and eclampsia in Shashemene referral hospital and Melka Oda general hospital, 2021.</p><p><strong>Design: </strong>An institution-based exploratory qualitative study with a descriptive phenomenological study design.</p><p><strong>Setting: </strong>The present study was conducted in Shashemene referral hospital and Melka Oda general hospital from March 03 to May 18, 2021.</p><p><strong>Participants: </strong>A total of 17 individual in-depth interviews (IDIs) were conducted with women who experienced and survived pre-eclampsia and eclampsia. Data were analyzed through thematic analysis using Atlas-ti software.</p><p><strong>Result: </strong>The present study revealed that women's level of awareness on raised blood pressure and or convulsion occurring during pregnancy was poor. Barriers that limit pregnant women from getting treatment at the earliest point included misconception, lack of insight, failure to accept counseling from health care providers, low income, and influence from husbands. Discussions with the women in this study showed that these mothers were not counseled on danger signs during antenatal care check-ups. Almost all of the women were very concerned and frustrated due to their diagnosis.</p><p><strong>Conclusions: </strong>Women's awareness of pre-eclampsia and eclampsia was poor. Improving awareness of hypertensive disorders in pregnancy and enhancing the quality of antenatal care is essential.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"12 ","pages":"1464"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The quantified method for blood clot detection in the extraction socket.","authors":"Suwat Tanya, Piyachat Patcharanuchat, Sajee Sattayut","doi":"10.12688/f1000research.155330.1","DOIUrl":"10.12688/f1000research.155330.1","url":null,"abstract":"<p><strong>Background: </strong>Currently, there is no objective and quantified measurement for detecting blood clots during extraction socket hemostasis. It has relied solely on clinical observation, even when conducting clinical research by using extraction sockets as samples. This study aimed to assess the in vitro reliability and clinical-relevant validity of a new objective measurement providing quantified data called blood clot detection (BCD) using a standard capillary tube.</p><p><strong>Methods: </strong>The in vitro part of the study was conducted using surplus blood samples from ten healthy participants. Two identical sets of blood samples in simulation reservoirs mimicking bleeding sockets were prepared for reliability tests. Then, the capillary tubes were concurrently placed in the reservoirs. The blood-filled distances were measured. The part of clinical-relevant validity study was conducted in sixteen extraction sockets from each healthy participant. Clinical observation and BCD measurement were evaluated by two calibrated assessors. The total duration of the assessment was a 30-minute.</p><p><strong>Results: </strong>The distances of the blood-filled capillary tube were decreased by time. Test and retest reliability analysis of the BCD measurement showed an excellent intraclass correlation coefficient of 0.980 (0.968 to 0.988). The medians of blood-filled distance categorized by clinical observation into active bleeding, sluggish oozing, and clot formation were 13.0 mm (Q1 = 11.7, Q3 = 13.8), 5.6 mm (Q1 = 4.3, Q3 = 7.0), and 0.9 mm (Q1 = 0.5, Q3 = 1.3), respectively. The blood-filled distance of the clot formation group was significantly less than the active bleeding and sluggish oozing (p<0.001). Therefore, the BCD measurement also significantly indicated the completion of extraction socket hemostasis.</p><p><strong>Conclusions: </strong>A distance of blood-filled in capillary tube of 0.9 mm from the BCD measurement significantly ensured complete clot formation. The BCD measurement proved to be a quantified tool for objectively measuring hemostasis of bleeding socket.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1043"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11914871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Methimazole-Induced Parotitis - An Unusual Presentation.","authors":"Ricky Rana, Emily Krier, Abubakar Tauseef, Jalal Dufani","doi":"10.12688/f1000research.149569.3","DOIUrl":"https://doi.org/10.12688/f1000research.149569.3","url":null,"abstract":"<p><p>A 56-year-old female with a medical history of unspecified hyperthyroidism and a recent thyroid storm presented to the ED with tachycardia, hypertension, and bilateral enlarged parotid glands. During a previous hospitalization, she was diagnosed with unspecified hyperthyroidism and started on methimazole. During hospitalization, laboratory findings suggested Graves' disease with an acute thyroid storm. The patient also complained of enlarged parotid glands bilaterally. CT tomography of the neck revealed no calculi of the parotid glands but showed extensive fatty replacement, possibly related to methimazole use. Treatment with propranolol and IV hydrocortisone improved thyroid function. Due to the suspicion of methimazole-induced parotitis, she was transitioned to a reduced methimazole dosage for treatment of Graves' disease, which subsequently improved her parotitis. Methimazole, the standard initial treatment for Graves' disease, is generally well-tolerated. It can cause adverse reactions; however, parotitis is very rare and has been documented in only a few case reports. Owing to the limited number of reports, its incidence is currently unknown. Here, we present a case of methimazole-induced parotitis as an unusual presentation of thyroid storm. Drug-induced reactions can only be considered once common causes of parotitis such as viral infection, obstruction, and autoimmune diseases are ruled out. Treatment involves dosage adjustments and supportive care. Methimazole-induced parotitis is often misdiagnosed and overlooked because of the lack of reported cases. This necessitates future research into the reaction mechanisms and optimal treatment.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"447"},"PeriodicalIF":0.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12032518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fostering healthcare system sustainability through efficient practices: Can adopting biosimilars ease the financial burden of rheumatoid arthritis?","authors":"Christos Ntais, Nikolaos Kontodimopoulos, John Fanourgiakis, Michael A Talias","doi":"10.12688/f1000research.156983.2","DOIUrl":"https://doi.org/10.12688/f1000research.156983.2","url":null,"abstract":"<p><p>Immune-mediated inflammatory diseases like rheumatoid arthritis (RA) have been successfully treated using biologic disease-modifying antirheumatic drugs. These medications are not utilized as first-line treatment, in part because of their high cost, but they are frequently seen to be cost-effective for RA patient populations that do not respond adequately to conventional disease-modifying antirheumatic drugs. Moreover, not all RA patients who meet clinical eligibility criteria can access biologics, not even as second-line therapy. Recently, there has been an increasing interest in biosimilars that are highly comparable to their originator biologics in terms of efficacy and safety but generally come at a lower price. This review summarizes the potential role of biosimilars in reducing RA expenditure and increasing RA patient access to biologic therapies. As the global landscape for biosimilars continues to evolve, it is essential to consider the unique challenges and opportunities in different healthcare systems. By leveraging the potential of biosimilars, healthcare systems can improve RA management, ease its economic burden and ensure that patients have access to effective and affordable treatments. The future of RA treatment lies in the integration of biosimilars into clinical practice, offering hope for more sustainable and equitable healthcare systems.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1128"},"PeriodicalIF":0.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11983381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structuring data analysis projects in the Open Science era with Kerblam!","authors":"Luca Visentin, Luca Munaron, Federico Alessandro Ruffinatti","doi":"10.12688/f1000research.157325.1","DOIUrl":"10.12688/f1000research.157325.1","url":null,"abstract":"<p><strong>Background: </strong>Structuring data analysis projects, that is, defining the layout of files and folders needed to analyze data using existing tools and novel code, largely follows personal preferences. Open Science calls for more accessible, transparent and understandable research. We believe that Open Science principles can be applied to the way data analysis projects are structured.</p><p><strong>Methods: </strong>We examine the structure of several data analysis project templates by analyzing project template repositories present in GitHub. Through visualization of the resulting consensus structure, we draw observations regarding how the ecosystem of project structures is shaped, and what salient characteristics it has.</p><p><strong>Results: </strong>Project templates show little overlap, but many distinct practices can be highlighted. We take them into account with the wider Open Science philosophy to draw a few fundamental Design Principles to guide researchers when designing a project space. We present Kerblam!, a project management tool that can work with such a project structure to expedite data handling, execute workflow managers, and share the resulting workflow and analysis outputs with others.</p><p><strong>Conclusions: </strong>We hope that, by following these principles and using Kerblam!, the landscape of data analysis projects can become more transparent, understandable, and ultimately useful to the wider community.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"88"},"PeriodicalIF":0.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143565976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is relief the most common reaction to abortion? Self-assessed intensity of emotions attributed to abortion in a national sample of women aged 41 to 45.","authors":"David Reardon","doi":"10.12688/f1000research.162063.1","DOIUrl":"10.12688/f1000research.162063.1","url":null,"abstract":"<p><strong>Background: </strong>It is widely reported that the most prominent emotion following abortions is relief. This claim primarily rests on two studies of abortion clinic patients which had methodological and self-censure bias. Other studies have indicated that negative emotions are more common than positive emotions. The objective of this study is to obtain self-assessed data on the intensity of emotional responses to abortion and pregnancy loss in a random national sample.</p><p><strong>Methods: </strong>Using visual analog scales, a random sample of 1,925 women aged 41 to 45 completed a survey in which respondents rated the degree to which they experienced emotional responses to their first abortion or natural pregnancy loss. The emotions assessed included relief, grief, depression, anxiety, guilt, emptiness, anger, regret, shame, unforgiveness of self, uncontrollable weeping, frequent thoughts of the child they could have had, and difficulty completing the grief process. Women were categorized into five groups based on pregnancy outcomes, and four abortion decision types: Wanted, Inconsistent, Unwanted, or Coerced.</p><p><strong>Results: </strong>Among women with a history of abortion (n=409), negative emotions were reported more intensely than relief. Relief was the predominant emotion only among the 29.8% of women whose abortions were freely wanted and consistent with their own values and preferences. For all other groups, relief was low and negative emotions were more prominent. Emotions following natural pregnancy losses were similar to those following abortion, but less severe following wanted abortions and more severe following coerced abortions.</p><p><strong>Conclusions: </strong>Relief is only common after freely wanted abortions. Most abortions are inconsistent or contrary to women's own values. In these cases, strong negative emotions are far more dominant than relief. These results should inform pre-abortion screening, counseling supportive of women's own values and preferences, and mental health support post-abortion.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"240"},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11933783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodology used to develop the minimum common data elements for surveillance and Reporting of Musculoskeletal Injuries in the MILitary (ROMMIL) statement.","authors":"Garrett S Bullock, Joanne L Fallowfield, Sarah J de la Motte, Nigel Arden, Ben Fisher, Adam Dooley, Neil Forrest, John J Fraser, Alysia Gourlay, Ben R Hando, Katherine Harrison, Debra Hayhurst, Joseph M Molloy, Phillip M Newman, Eric Robitaille, Deydre S Teyhen, Jeffrey M Tiede, Emma Williams, Sandra Williams, Damien Van Tiggelen, Joshua J Van Wyngaarden, Richard B Westrick, Carolyn A Emery, Gary S Collins, Daniel I Rhon","doi":"10.12688/f1000research.152514.1","DOIUrl":"10.12688/f1000research.152514.1","url":null,"abstract":"<p><strong>Background: </strong>The objective was to summarize the methodology used to develop the international minimum data elements for surveillance and Reporting of Musculoskeletal Injuries in the MILitary (ROMMIL) statement. This is a recommended list of elements to be collected and reported when conducting injury surveillance research in military settings.</p><p><strong>Methods: </strong>A Delphi methodology was employed to reach consensus. Preliminary steps included conducting a literature review and surveying a convenience sample of military stakeholders to 1) identify barriers and facilitators of military musculoskeletal injury (MSKI) prevention programs, 2) identify relevant knowledge gaps, and 3) establish future research priorities. A sequential three-round Delphi consensus survey followed, including relevant stakeholders from militaries around the world, using results to conduct an asynchronous knowledge user meeting (mixture of in-person and live video conference and recording) to explore the level of agreement among subject matter experts. Knowledge users, including former and current military service members, civilian practitioners working in military health networks, and international subject matter experts having experience with policy, execution, or clinical investigation of MSKI mitigation programs, MSKI diagnoses, and MSKI risk factors in military settings. For each round, participants scored questions on a Likert scale of 1-5. Scores ranged from No Importance (1) to Strong Importance (5).</p><p><strong>Results: </strong>Literature review and surveys helped inform the scope of potential variables. Three rounds were necessary to reach minimum consensus. Ninety-five, 65, and 42 respondents participated in the first, second and third rounds, respectively.</p><p><strong>Conclusions: </strong>Achieving consensus across relevant knowledge users representing military organizations globally can be challenging. This paper details the methodology employed to reach consensus for a core minimum data elements checklist for conducting MSKI research in military settings and improve data harmonization and scalability efforts. These methods can be used as a resource to assist in future consensus endeavors of similar nature.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1044"},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11621606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Searching for non-English literature may be unnecessary for German HTA Reports.","authors":"Elke Hausner, Sibylle Sturtz, Sandra Molnar, Lisa Schell, Wiebke Sieben, Stefan Sauerland","doi":"10.12688/f1000research.151365.2","DOIUrl":"https://doi.org/10.12688/f1000research.151365.2","url":null,"abstract":"<p><strong>Background: </strong>Health technology assessment (HTA) reports are based on comprehensive information retrieval. Current standards discourage the use of search restrictions, such as publication date and language. Given limited resources, it was unclear whether the effort invested in screening and translating studies published in languages other than English provided relevant additional information compared with the inclusion of English-language publications alone. We therefore analysed the impact of non-English publications on the conclusions of HTA reports produced by the German HTA agency, the Institute for Quality and Efficiency in Health Care (IQWiG).</p><p><strong>Methods: </strong>We determined whether non-English publications were included in all German HTA reports on non-drug interventions (published by IQWiG between 06/2007 to 08/2018) and on selected drug interventions. If at least one non-English publication was included, we assessed for each endpoint whether or not the exclusion of non-English publications changed the conclusion. If a non-English publication did not contain information relevant to the HTA report, we classified the publication as \"not relevant\".</p><p><strong>Results: </strong>Of 70 HTA reports, 38 (54%) included 126 non-English publications. In 4 reports (6%) with 50 endpoints investigated in 39 PICO questions, the exclusion of a total of 10 non-English publications led to a change in the conclusions for 13 endpoints (8 PICO questions). This was largely due to the fact that in many cases, non-English publications were the predominant or only literature available, resulting in a lack of analysable data after their exclusion.</p><p><strong>Conclusions: </strong>In general, studies only published in non-English languages have little influence on the conclusions of German HTA reports. For the vast majority of topics, a language restriction to English seems justified. Studies published in non-English languages may be useful in exceptional cases, for example when an intervention is only available in certain countries.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1134"},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12012429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of surface treatments on the bond strength of polyetheretherketone posts: a systematic review protocol.","authors":"Hanen Boukhris, Aymen Ben Hadj Khalifa, Hayet Hajjami, Souha Boudegga Ben Youssef","doi":"10.12688/f1000research.154750.3","DOIUrl":"https://doi.org/10.12688/f1000research.154750.3","url":null,"abstract":"<p><strong>Background: </strong>Polyetheretherketone (PEEK) is widely used in the biomedical field due to its outstanding biological and mechanical properties. Originally employed as a temporary abutment in implantology, recent research has expanded its indications for more definitive applications, such as frameworks and dental post and core. However, PEEK's inert nature and low surface energy pose challenges for adhesion, necessitating surface modifications. Various physical and chemical modification techniques, including acid etching (e.g., 98% sulfuric acid), sandblasting with alumina oxide (Al₂O₃), plasma treatment, laser irradiation, silanization, and air abrasion with silica-coated particles, have been proposed to enhance PEEK's bonding performance. Despite numerous clinical investigations, standardized protocols for surface treatment remain lacking. This systematic review aims to assess the impact of surface treatments on the bonding performance of PEEK posts.</p><p><strong>Methods: </strong>A detailed search of the literature will be conducted across several databases including PubMed, Scopus and clinical trial registries. Additional databases such as Cochrane Central, EMBASE, Web of Science and EBSCO will also be included. The search strategy will target controlled randomized studies and non-randomized clinical trials evaluating the impact of surface treatments on PEEK post adhesion strength. The Newcastle-Ottawa Scale (NOS) will be used to assess bias in non-randomized studies, while the Cochrane Risk of Bias (ROB II) tool will be employed for evaluating randomized controlled trials. Data extraction will focus on study design, treatment methods, outcomes and results.This systematic review protocol will adhere to the guidelines for systematic reviews outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).</p><p><strong>Discussion: </strong>The discussion will explore the implications of findings on clinical practice, highlighting the importance of enhancing PEEK's bioactivity and surface energy to improve bonding efficacy in dental procedures. Moreover, it will suggest areas for future research to advance dental materials science, aiming to optimize the utilization of PEEK in dental applications.</p><p><strong>Systematic review registration: </strong>PROSPERO: CRD42024529783 (Registered on 08/04/2024).</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"951"},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12008716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}