F1000ResearchPub Date : 2025-02-04eCollection Date: 2023-01-01DOI: 10.12688/f1000research.138866.2
Buthaina Alkhatib, Huda Al Hourani, Islam K Al-Shami, Ayoub Al-Jawaldeh
{"title":"Food consumption and adherence to dietary guidelines among Jordanian children and adolescents.","authors":"Buthaina Alkhatib, Huda Al Hourani, Islam K Al-Shami, Ayoub Al-Jawaldeh","doi":"10.12688/f1000research.138866.2","DOIUrl":"10.12688/f1000research.138866.2","url":null,"abstract":"<p><strong>Background: </strong>Early-life food consumption patterns may affect children's health by increasing susceptibility to developing non-communicable chronic diseases (NCDs) in adulthood.</p><p><strong>Aims: </strong>To evaluate Jordanian children and adolescents' energy and macronutrient intake and how closely they adhere to dietary recommendations.</p><p><strong>Methods: </strong>This cross-sectional study used data from Jordan's Population-based Food Consumption Survey, a household population-based study conducted in Jordan between 2021 and 2022 (561 children and adolescents 8-19 years). Dietary intake was assessed using the two non-consecutive 24-hour dietary recall methods (24-h DR). The estimated food group and nutrient intakes were compared to nutritional recommendations, including MyPlate dietary guidelines.</p><p><strong>Results: </strong>The prevalence of overweight/obese individuals based on body mass index (BMI) was 44%, and the average waist-to-height ratio (WHtR) was 24.7%. Compared to MyPlate dietary guidelines, children and adolescents had a higher added sugar intake (57g/day). Also, consuming vegetables, fruits, and dairy fell short of MyPlate dietary guidelines. The total discretionary calorie intake in children and adolescents was approximately one-third of the total energy intake.</p><p><strong>Conclusion: </strong>The food consumption of Jordanian children and adolescents includes high intakes of discretionary calories, with a low intake of fruits, vegetables, and dairy products. The prevalence of overweight/obesity was elevated compared to international norms.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"12 ","pages":"1094"},"PeriodicalIF":0.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11409655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F1000ResearchPub Date : 2025-02-04eCollection Date: 2025-01-01DOI: 10.12688/f1000research.161261.1
Edgar López-López, Ana Margarita Hernández-Segura, Carlos Lara-Cuellar, Carolina Barrientos-Salcedo, Carlos M Cerda-García-Rojas, José L Medina-Franco
{"title":"Nat-UV DB: A Natural Products Database Underlying of Veracruz-Mexico.","authors":"Edgar López-López, Ana Margarita Hernández-Segura, Carlos Lara-Cuellar, Carolina Barrientos-Salcedo, Carlos M Cerda-García-Rojas, José L Medina-Franco","doi":"10.12688/f1000research.161261.1","DOIUrl":"10.12688/f1000research.161261.1","url":null,"abstract":"<p><strong>Background: </strong>Natural products databases are well-structured data sources that offer new molecular development opportunities in drug discovery, agrochemistry, food, cosmetics, and several other research disciplines or chemical industries. The crescent world's interest in the development of these databases is related to the exploration of chemical diversity in geographical regions with rich biodiversity.</p><p><strong>Methods: </strong>In this work, we introduce and discuss Nat-UV DB, the first natural products database from a coastal zone of Mexico. We discuss its construction, curation, and chemoinformatic characterization of their content, and chemical space coverage compared with other compound databases, like approved drugs, and other Mexican (BIOFACQUIM and UNIIQUIM databases) and the Latin American natural products database (LaNAPDB).</p><p><strong>Results: </strong>Nat-UV DB comprises 227 compounds that contain 112 scaffolds, of which 52 are not present in previous natural product databases. The compounds present in Nat-UV DB have a similar size, flexibility, and polarity to previously reported natural products and approved drug datasets.</p><p><strong>Conclusions: </strong>Nat-UV DB compounds have a higher structural and scaffold diversity than the approved drugs, but they have low structural and scaffold diversity in contrast with other natural products in the reference datasets. This database serves as a valuable addition to the global natural products landscape, bridging gaps in exploring biodiversity-rich regions.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F1000ResearchPub Date : 2025-02-04eCollection Date: 2025-01-01DOI: 10.12688/f1000research.161433.1
{"title":"RETRACTED: Efficacy and risk of sexual orientation change efforts: retrospective analysis of 125 exposed men.","authors":"","doi":"10.12688/f1000research.161433.1","DOIUrl":"https://doi.org/10.12688/f1000research.161433.1","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.12688/f1000research.51209.2.].</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"151"},"PeriodicalIF":0.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluating the Efficacy of the Newborn Communication, Health, Feeding, and Swallowing Education Program (N-CHFSEP) for First-Time Mothers in Mangalore taluk, Dakshina Kannada district, Karnataka, India: A Preliminary Study.","authors":"Deepthi Ouseph, Jayashree Kanthila, Sunil Baliga, Shraddha Shetty, Sudhin Karuppali","doi":"10.12688/f1000research.152320.2","DOIUrl":"10.12688/f1000research.152320.2","url":null,"abstract":"<p><strong>Background: </strong>Primiparous mothers face diverse challenges during pregnancy and post-childbirth. There is limited data on the effectiveness of postnatal educational programs for new mothers (Subramanian et al., 2020). This study aimed to assess the efficacy of an educational program designed to improve primiparous mothers' attitudes toward newborn communication, general health, feeding, and swallowing. The objectives were (1) to develop an attitude questionnaire (AQ), a parent education program [Newborn Communication, Health, Feeding and Swallowing Education Program (N-CHFSEP)], and a feedback questionnaire (FQ); and (2) to estimate the efficacy of N-CHFSEP pre- and post-delivery. The research, conducted between August 2023 and February 2024, involved 98 primiparous mothers who gave birth to healthy newborns through any delivery method. Participants were proficient in English or Kannada. The study excluded mothers delivering multiples, those with significant medical or psychological issues, and health professionals.</p><p><strong>Methods: </strong>The study had two phases: Phase 1 developed and validated the AQ, N-CHFSEP, and FQ. N-CHFSEP covered key topics, including milestones in communication, feeding, and general health from birth to 6 months. Phase 2 administered these tools to participants. The data was analyzed using descriptive statistics, paired t-tests, and chi-square tests.</p><p><strong>Results: </strong>93% of mothers reported increased confidence in recognizing communication, feeding, and health-related signs in their infants after completing the program. This change was statistically significant (p < 0.05). Sociodemographic factors like maternal age, education, occupation, and family type significantly influenced confidence levels. Feedback from participants highlighted the program's effectiveness in enhancing knowledge, with suggestions for improvements.</p><p><strong>Conclusions: </strong>N-CHFSEP significantly boosted mothers' confidence in newborn care, contributing to better maternal and infant health. However, the study lacked a control group, and the effectiveness was evaluated only immediately after the program. Future research could incorporate practical demonstrations and hands-on training to further enhance the program's impact.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"777"},"PeriodicalIF":0.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11862371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F1000ResearchPub Date : 2025-01-31eCollection Date: 2024-01-01DOI: 10.12688/f1000research.154408.2
Jeremy Y Ng, Henry Liu, Mehvish Masood, Rubaina Farin, Mireille Messih, Amaya Perez, IJsbrand Jan Aalbersberg, Juan Alperin, Gregory L Bryson, Qiuxia Chen, Alan Ehrlich, Alfonso Iorio, Wim J N Meester, John Willinsky, Agnes Grudniewicz, Erik Cobo, Imogen Cranston, Phaedra Eve Cress, Julia Gunn, R Brian Haynes, Bibi Sumera Keenoo, Ana Marušić, Eleanor-Rose Papas, Alan Purvis, João de Deus Barreto Segundo, Pathiyil Ravi Shankar, Pavel Stoev, Josephine Weisflog, Margaret Winker, Kelly D Cobey, David Moher
{"title":"Publisher preferences for a journal transparency tool: A modified three-round Delphi study.","authors":"Jeremy Y Ng, Henry Liu, Mehvish Masood, Rubaina Farin, Mireille Messih, Amaya Perez, IJsbrand Jan Aalbersberg, Juan Alperin, Gregory L Bryson, Qiuxia Chen, Alan Ehrlich, Alfonso Iorio, Wim J N Meester, John Willinsky, Agnes Grudniewicz, Erik Cobo, Imogen Cranston, Phaedra Eve Cress, Julia Gunn, R Brian Haynes, Bibi Sumera Keenoo, Ana Marušić, Eleanor-Rose Papas, Alan Purvis, João de Deus Barreto Segundo, Pathiyil Ravi Shankar, Pavel Stoev, Josephine Weisflog, Margaret Winker, Kelly D Cobey, David Moher","doi":"10.12688/f1000research.154408.2","DOIUrl":"10.12688/f1000research.154408.2","url":null,"abstract":"<p><strong>Background: </strong>We propose the creation of a journal transparency tool (JTT), which will allow users to obtain information about a given scholarly journal's operations and policies. We are obtaining preferences from different stakeholders to inform the development of this tool. This study aimed to identify the publishing community's preferences for the JTT.</p><p><strong>Methods: </strong>We conducted a modified three-round Delphi survey. Representatives from publishing houses and journal publishers were recruited through purposeful and snowball sampling. The first two Delphi rounds involved an online survey with items about JTT metrics and user features. During the third round, participants discussed and voted on JTT metric items that did not reach consensus after round 2 within a virtual consensus meeting. We defined consensus as 80% agreement to include or exclude an item in the JTT.</p><p><strong>Results: </strong>Eighty-six participants completed the round 1 survey, and 43 participants (50% of round 1) completed the round 2 survey. In both rounds, respondents voted on JTT user feature and JTT metric item preferences and answered open-ended survey questions regarding the JTT. In round 3, a total of 21 participants discussed and voted on JTT metric items that did not reach consensus after round 2 during an online consensus group meeting. Fifteen out of 30 JTT metric items and none of the four JTT user feature items reached the 80% consensus threshold after all rounds of voting. Analysis of the round 3 online consensus group transcript resulted in two themes: 'factors impacting support for JTT metrics' and 'suggestions for user clarity.'</p><p><strong>Conclusions: </strong>Participants suggested that the publishing community's primary concerns for a JTT are to ensure that the tool is relevant, user-friendly, accessible, and equitable. The outcomes of this research will contribute to developing and refining the tool in accordance with publishing preferences.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"915"},"PeriodicalIF":0.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F1000ResearchPub Date : 2025-01-30eCollection Date: 2024-01-01DOI: 10.12688/f1000research.157194.2
Javier Andrés Soto, Andrea Catalina Gómez, Maryeli Vásquez, Andrea Natalia Barreto, Karen Shirley Molina, C A Zuniga-Gonzalez
{"title":"Biological properties of <i>Moringa oleifera</i>: A systematic review of the last decade.","authors":"Javier Andrés Soto, Andrea Catalina Gómez, Maryeli Vásquez, Andrea Natalia Barreto, Karen Shirley Molina, C A Zuniga-Gonzalez","doi":"10.12688/f1000research.157194.2","DOIUrl":"10.12688/f1000research.157194.2","url":null,"abstract":"<p><strong>Background: </strong>The growing incidence of chronic diseases such as cancer and the emergence of drug-resistant microorganisms constitute one of the greatest health challenges of the 21st century. Therefore, it is critical to search for new therapeutic alternatives. <i>Moringa oleifera</i> is a plant well known for the properties of its phytocomponents and its role has been analyzed in a variety of fields, from medicine to biotechnology.</p><p><strong>Methods: </strong>In this work, the biological activity of <i>Moringa oleifera</i> in human health was explored through a review of 129 original articles published between 2010 and 2021 related to antitumor activity and its potential uses against chronic and infectious diseases.</p><p><strong>Results: </strong><i>Moringa oleifera</i> extracts showed antioxidant, hypoglycemic, antihypertensive and cytoprotective properties at neuronal, hepatic, renal and cardiac levels. Besides, cytotoxic effects, apoptotic and antiploriferative activity against several cancer cell lines has been demonstrated. On the other hand, the antimicrobial potential of <i>M. oleifera</i> was also evidenced, especially against multidrug-resistant strains.</p><p><strong>Conclusions: </strong>Hence, it is supported that there is a wide range of clinical entities in which <i>Moringa oleifera</i> exhibits significant biological activity that could contribute to counteracting metabolic, infectious and chronic diseases in a similar or improved way to the drugs traditionally used.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1390"},"PeriodicalIF":0.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11782934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unveiling the Group A Streptococcus Vaccine-Based L-Rhamnose from Backbone of Group A Carbohydrate: Current Insight Against Acute Rheumatic Fever to Reduce the Global Burden of Rheumatic Heart Disease.","authors":"Ade Meidian Ambari, Faqrizal Ria Qhabibi, Dwita Rian Desandri, Bambang Dwiputra, Pirel Aulia Baravia, Indira Kalyana Makes, Basuni Radi","doi":"10.12688/f1000research.144903.3","DOIUrl":"10.12688/f1000research.144903.3","url":null,"abstract":"<p><p>Group A Streptococcus (GAS) is a widely distributed bacterium that is Gram-positive and serves as the primary cause of acute rheumatic fever (ARF) episodes. Rheumatic heart disease (RHD) is a sequela resulting from repeated ARF attacks which are also caused by repeated GAS infections. ARF/RHD morbidity and mortality rates are incredibly high in low- and middle-income countries. This is closely related to poor levels of sanitation which causes the enhanced incidence of GAS infections. Management of carditis in RHD cases is quite challenging, particularly in developing countries, considering that medical treatment is only palliative, while definitive treatment often requires more invasive procedures with high costs. Preventive action through vaccination against GAS infection is one of the most effective steps as a solution in reducing RHD morbidity and mortality due to curative treatments are expensive. Various developments of M-protein-based GAS vaccines have been carried out over the last few decades and have recently begun to enter the clinical stage. Nevertheless, this vaccination generates cross-reactive antibodies that might trigger ARF assaults as a result of the resemblance between the M-protein structure and proteins found in many human tissues. Consequently, the development of a vaccine utilizing <sub>L</sub>-Rhamnose derived from the poly-rhamnose backbone of Group A Carbohydrate (GAC) commenced. The <sub>L</sub>-Rhamnose-based vaccine was chosen due to the absence of the Rhamnose biosynthesis pathway in mammalian cells including humans thus this molecule is not found in any body tissue. Recent pre-clinical studies reveal that <sub>L</sub>-Rhamnose-based vaccines provide a protective effect by increasing IgG antibody titers without causing cross-reactive antibodies in test animal tissue. These findings demonstrate that the <sub>L</sub>-Rhamnose-based vaccine possesses strong immunogenicity, which effectively protects against GAS infection while maintaining a significantly higher degree of safety.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"132"},"PeriodicalIF":0.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11829149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluating the Efficacy of Gelatin-Chitosan-Tetraethyl Orthosilicate Calcium Hydroxide Composite as a Dental Pulp Medicament on COX-2, PGP 9.5, TNF-α Expression and Neutrophil number.","authors":"Al-Qatta Ghadah Abdulrahman, Endytiastuti Endytiastuti, Retno Ardhani, Iwa Sutardjo Rus Sudarso, Bidhari Pidhatika, Mh Busra Fauzi, Heni Susilowati, Yulita Kristanti, Juni Handajani","doi":"10.12688/f1000research.156336.2","DOIUrl":"10.12688/f1000research.156336.2","url":null,"abstract":"<p><strong>Introduction: </strong>Calcium hydroxide (Ca(OH) <sub>2</sub>) is the material of choice for pulp therapy. However, Ca(OH) <sub>2</sub> has drawbacks such as toxicity, poor sealing, and tunnel defect formation. Alternative materials have been developed to provide more biocompatible materials with better dentin formation ability. The objective of this study was to evaluate the effect of composites containing gelatin (G), chitosan (CH), tetraethyl orthosilicate (TEOS), and Ca(OH) <sub>2</sub>, namely G-CH-TEOS-Ca (OH) <sub>2</sub> (Extended data) on inflammation of the dental pulp (expression of COX-2, PGP 9.5, TNF-α, and neutrophil number).</p><p><strong>Materials and methods: </strong>A total of 16 Wistar rat models of acute pulp injury were prepared and divided into two groups, treatment and control, 8 with each. In the treatment group, we applied a pulp-capping material using G-CH-TEOS-Ca (OH) <sub>2</sub> and Ca(OH) <sub>2</sub>. On the 1 <sup>st</sup> and 3 <sup>rd</sup> days, rats were sacrificed. Tissue samples from 4 rats in each group were processed for histological preparation. COX-2, PGP 9.5, and TNF-α were observed using immunohistochemical (IHC) staining, and neutrophil numbers were observed using hematoxylin-eosin staining. Image analysis of COX-2, PGP 9.5, and TNF-α expression was performed using ImageJ software.</p><p><strong>Results: </strong>The results showed a decrease in COX-2 expression, but not significantly while PGP 9.5 and TNF-α expression were significantly higher than those in the control group. Neutrophil numbers were lower in the treatment group than in the control group, but the difference was not statistically significant.</p><p><strong>Conclusion: </strong>The G-CH-TEOS-Ca (OH) <sub>2</sub> composite material may have potential as an exposed pulp medicament by reducing inflammation (COX-2 expression and number of neutrophils) and increasing the regeneration factor (TNF-α expression) and nerve (PGP 9.5 expression).</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1258"},"PeriodicalIF":0.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11862375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F1000ResearchPub Date : 2025-01-30eCollection Date: 2025-01-01DOI: 10.12688/f1000research.160479.1
Divya Mishra, Arun S Urala, Ashwath S Nayak, Divya S, Rajay Kamath, Lakshmi Narayan Bairy, Gargi S
{"title":"A Randomized Controlled Trial Evaluating the Effect of Local Application of Sodium Alendronate Gel and Low-Level Laser Therapy (LLLT) On Peri-Implant Tissue Healing in Wistar Rats.","authors":"Divya Mishra, Arun S Urala, Ashwath S Nayak, Divya S, Rajay Kamath, Lakshmi Narayan Bairy, Gargi S","doi":"10.12688/f1000research.160479.1","DOIUrl":"https://doi.org/10.12688/f1000research.160479.1","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effect of local application of Sodium Alendronate incorporated in Carbapol gel together with LLLT on peri-implant tissue healing in Wistar rat femurs.</p><p><strong>Methods: </strong>Twenty-four male Wistar rats were randomly divided into 4 groups: Group 1 (the control group), Group 2 (the Sodium Alendronate group), Group 3 (the Sodium Alendronate and LLLT group), and Group 4 (the LLLT group). Mini implants were placed in right and left femur bones in all the four groups. Implants of groups 2 and 3 were coated in 1mg Carbapol gel incorporated with 1 mg Sodium alendronate. Groups 3 and 4 were exposed to LLLT (CO <sub>2</sub> laser, wavelength 830nm; 2.1J/cm <sup>2</sup>) on 1 <sup>st,</sup> 7 <sup>th</sup>, 14 <sup>th</sup> and 21 <sup>st</sup> day. Animals were sacrificed on the 28th day, following which the femurs were dissected out and stored in 10% buffered formaldehyde for histopathological analysis.</p><p><strong>Results: </strong>Groups 3 and 4 showed bony union and formation of reorganized spongiosa whereas Groups 1 and 2 showed fibrous union. The bone marrow from Group 3 had an adult-type fatty marrow, while that from Group 2 and 4 was occupied by red blood cells. Group 1 showed initial stages of bone healing in which the defect occupied more than half of the bone marrow.</p><p><strong>Conclusion: </strong>LLLT given using CO <sub>2</sub> laser therapy, together with a one-time application of Sodium Alendronate in Carbapol gel at the time of implant placement optimally enhances healing of peri-implant tissues.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"147"},"PeriodicalIF":0.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Understanding the Dynamics of consumer behaviour and purchase intentions for Green Cosmetic Products in North India: A Gender-Neutral Approach.","authors":"Neha Singh, Babita Rawat, Dhani Shanker Chaubey, Ambica Prakash Mani, Aditi Singh","doi":"10.12688/f1000research.151629.2","DOIUrl":"10.12688/f1000research.151629.2","url":null,"abstract":"<p><strong>Background: </strong>The increasing popularity of green cosmetic products among consumers who prioritize skin health, quality, and beauty has driven the production of these products. Growing awareness of harmful toxins in traditional cosmetics is leading consumers to prefer natural alternatives. This study aimed to identify the factors influencing Indian consumers' buying behaviour and purchase intentions toward green cosmetics, focusing on both male and female consumers.</p><p><strong>Methods: </strong>To achieve this, a thorough evaluation of the literature from Scopus-indexed journals was conducted, employing the theory of planned behavior as the theoretical framework. The study used Smart PLS 3.0's structural equation modeling to analyze data and performed a multi-group analysis to explore variations in purchasing intentions and actions between male and female consumers.</p><p><strong>Results: </strong>The research indicated an increasing demand for green cosmetics among males in North India. Findings revealed that subjective norms significantly influenced both purchase behaviour and purchase intention. Additionally, perceived behavioural control and subjective norms positively impacted purchase intention, which in turn indirectly affected purchase behaviour. Interestingly, environmental concerns did not influence consumers' actual purchasing intentions or behaviour. The analysis also demonstrated no significant differences between male and female consumers regarding the impact of various factors on their purchase intentions and behaviours.</p><p><strong>Conclusion: </strong>These findings provide valuable insights for policymakers and marketing managers aiming to promote green cosmetic product purchase behaviour. Recognizing that subjective norms and perceived behavioural control are crucial drivers of purchase intention and behaviour can help in devising effective marketing strategies. Despite the absence of significant gender differences in the factors influencing purchase behaviour, the increasing interest in green cosmetics, especially among males, highlights a broader market potential for these products. This research underscores the importance of focusing on social and behavioural influences to encourage the adoption of green cosmetics.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"611"},"PeriodicalIF":0.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11799759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}