F1000Research最新文献

{"title":"Assessment of treatment expectations in people with suspected endometriosis: A psychometric analysis.","authors":"Ann-Katrin Meyrose, Lukas A Basedow, Nina Hirsing, Olaf Buchweitz, Winfried Rief, Yvonne Nestoriuc","doi":"10.12688/f1000research.145377.2","DOIUrl":"10.12688/f1000research.145377.2","url":null,"abstract":"<p><strong>Background: </strong>Treatment expectations influence clinical outcomes in various physical and psychological conditions; however, no studies have explored their role in endometriosis treatment. It is necessary to understand how these expectations can be measured to study treatment expectations and their effects in clinical practice. This study aimed to psychometrically analyze and compare different treatment expectation measurements and describe treatment expectations in women with suspected endometriosis.</p><p><strong>Method: </strong>Analysis of cross-sectional baseline data of a mixed-method clinical observational study of <i>N</i>=699 patients undergoing laparoscopy in Germany. Descriptives, bivariate associations, convergent and discriminant validity of four expectation measurements (Treatment Expectation Questionnaire (TEX-Q); Generic rating scale for previous treatment experiences, treatment expectations, and treatment effects (GEEE); numerical rating scales (NRS) assessing improvement and worsening of endometriosis symptoms, expected Pain Disability Index (PDI); range: 0 to 10) were estimated. A cluster analysis was performed on the three GEEE items.</p><p><strong>Results: </strong>Most participants expected high improvement ( <i>M</i>=6.68 to 7.20, <i>SD</i>=1.90 to 2.09) and low worsening ( <i>M</i>=1.09 to 2.52, <i>SD</i>=1.80 to 2.25) of disability from laparoscopy. Participants who expected greater worsening expected more side effects ( <i>r</i>=.31 to .60, <i>p</i><.001). Associations between the positive and negative expectation dimensions, including side effects, were small to non-significant ( <i>r</i> =|.24| to .00, <i>p</i><.001 to.978). Four distinct clusters, described as'positive', 'no pain, no gain', 'diminished', and 'uniform' were found, with a total PVE of 62.2%.</p><p><strong>Conclusions: </strong>Women with suspected endometriosis reported positive expectations concerning laparoscopy, but wide ranges indicated interindividual differences. Treatment expectations seem to be a multidimensional construct in this patient group. The investigated measurements did not correlate to the extent that they measured exactly the same construct. The selection of measurements should be carefully considered and adapted for the study purposes. Clusters provide initial indications for individualized interventions that target expectation manipulation.</p><p><strong>Trial registration number: </strong>ID NCT05019612 ( ClinicalTrials.gov).</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"174"},"PeriodicalIF":0.0,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11425038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analytical approach to piezoelectric model synthesis with the use of Cauer's method for system design.","authors":"Jacek Harazin, Andrzej Wróbel","doi":"10.12688/f1000research.140943.2","DOIUrl":"https://doi.org/10.12688/f1000research.140943.2","url":null,"abstract":"<p><strong>Background: </strong>Piezoceramic materials have unique property which enables direct and bilateral conversion between mechanical and electrical energy. This ability facilitates significant miniaturisation of technology and opens many opportunities in design of new actuators and energy harvesters. Mathematical modelling of piezoelectric modules is notoriously hard due to complex constitutive equations defining mechanical and electrical energy conversion.</p><p><strong>Methods: </strong>The article presents research on a new synthesis method based on the Cauer's method. Mechanical damping is introduced with the use of Rayleigh's approximation. A discrete electromechanical model is formed based on the Mason's piezoelectric model. The proposed approach allows modelling of piezoelectric systems based on a set of characteristic frequencies. The method allows a more general approach to the problem of modelling new systems, as opposed to application-oriented methods seen in literature. A non-standard model analysis method using edge graphs and structural numbers is also verified as a potential alternative for matrix-based method. The authors compare their precision and computation requirements.</p><p><strong>Results: </strong>The structural method of mechanical model analysis gave identical results as the reference matrix method. However, the non-classical algorithm took much longer to calculate and was using more memory. The electromechanical model analysis has shown an error of 5% in comparison to resonance frequencies taken from a reference plate specification. The calculated magnitude of displacement was well above the capability of a 3.5mm thick piezoelectric plate.</p><p><strong>Conclusions: </strong>The synthesis method presented in this paper allows synthesizing piezoelectric cascade models based on limited information in form of characteristic frequencies. Currently this method allows a coarse approximation of the real piezoelectric parameters with limited number of inputs. The additional method of analysis based on structural numbers offers a promising alternative to matrix calculations but requires a more thorough investigation of the computational power required to determine whether it can compete with existing algorithms.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"12 ","pages":"1273"},"PeriodicalIF":0.0,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11384192/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insomnia in teachers at the time of resumption of in-person instruction at schools amidst the COVID-19 pandemic: A cross-sectional study.","authors":"Sowmini Padmanabh Kamath, Prasanna Mithra, Padmanabh Kamath, Bhaskaran Unnikrishnan","doi":"10.12688/f1000research.141274.2","DOIUrl":"https://doi.org/10.12688/f1000research.141274.2","url":null,"abstract":"<p><strong>Background: </strong>The coronavirus (COVID-19) pandemic has affected people's economies, lifestyles, and physical, emotional, and sleep health. This research aimed to estimate the prevalence of insomnia and symptoms of stress, anxiety, and depression among teachers with the resumption of in-person instruction at schools following a hiatus after COVID-19 lockdowns in India. We also studied the association of teachers' insomnia with psychological symptoms and demographic variables.</p><p><strong>Methods: </strong>We conducted a cross-sectional survey between October -November 2021 after schools had reopened during the COVID-19 pandemic. Data was collected using standard questionnaires online among schoolteachers. We explored the association of insomnia with teachers' symptoms of stress, anxiety, depression, sex, school boards, and age groups.</p><p><strong>Results: </strong>Of 124 schoolteachers surveyed, the prevalence of insomnia was 37.9% (subthreshold in 25% and clinical in 12.9%). The prevalence of stress, depression, and anxiety was 20.2%, 30.6%, and 45.2%, respectively. There was a significant association (p<0.001) of insomnia with symptoms of anxiety, stress, and depression in univariate analysis. On multivariate analysis, we found that those feeling stressed had a 6.4 times higher risk of insomnia (95% CI: 1.5-28.3, p - 0.01). There was no association of insomnia with age, sex, school educational boards, and type of institution.</p><p><strong>Conclusions: </strong>Over one-third (37.9%) of teachers reported having trouble sleeping when they returned to the school's typical face-to-face instruction modalities through COVID-19 times, and insomnia was more prevalent in those with stress.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"12 ","pages":"1217"},"PeriodicalIF":0.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11425037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of high-performing antibodies for SPARC-related modular calcium-binding protein 1 (SMOC-1) for use in Western Blot and immunoprecipitation.","authors":"Riham Ayoubi, Sara González Bolívar, Michael Nicouleau, Kathleen Southern, Carl Laflamme","doi":"10.12688/f1000research.141800.2","DOIUrl":"https://doi.org/10.12688/f1000research.141800.2","url":null,"abstract":"<p><p>SPARC-related modular calcium-binding protein 1, otherwise known as SMOC-1, is a secreted glycoprotein involved in various cell biological processes including cell-matrix interactions, osteoblast differentiation, embryonic development, and homeostasis. SMOC-1 was found to be elevated in asymptomatic Alzheimer's disease (AD) patient cortex as well as being enriched in amyloid plaques and in AD patientcerebrospinal fluid, arguing for SMOC-1 as a promising biomarker for AD. Having access to high-quality SMOC-1 antibodies is crucial for the scientific community. It can ensure the consistency and reliability of SMOC-1 research, and further the exploration of its potential as both a therapeutic target or diagnostic marker.. In this study, we characterized seven SMOC-1 commercial antibodies for Western blot and immunoprecipitation, using a standardized experimental protocol based on comparing read-outs in knockout cell lines and isogenic parental controls. We identified successful antibodies in the tested applications and encourage readers to use this report as a guide to select the most appropriate antibody for their specific needs.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"12 ","pages":"1279"},"PeriodicalIF":0.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11406118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A guide to selecting high-performing antibodies for CSNK2A1 (UniProt ID: P68400) for use in western blot, immunoprecipitation and immunofluorescence.","authors":"Riham Ayoubi, Maryam Fotouhi, Charles Alende, Vera Ruíz Moleón, Kathleen Southern, Carl Laflamme","doi":"10.12688/f1000research.153243.2","DOIUrl":"https://doi.org/10.12688/f1000research.153243.2","url":null,"abstract":"<p><p>Casein kinase II subunit alpha (CSNK2A1), a serine/threonine kinase, phosphorylates multiple protein substrates and is involved in diverse cellular and biological processes. Implicated in various human diseases, high-performing antibodies would help evaluate its potential as a therapeutic target and benefit the scientific community. In this study, we have characterized ten CSNK2A1 commercial antibodies for western blot, immunoprecipitation, and immunofluorescence using a standardized experimental protocol based on comparing read-outs in knockout cell lines and isogenic parental controls. These studies are part of a larger, collaborative initiative seeking to address antibody reproducibility issues by characterizing commercially available antibodies for human proteins and publishing the results openly as a resource for the scientific community. While use of antibodies and protocols vary between laboratories, we encourage readers to use this report as a guide to select the most appropriate antibodies for their specific needs.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"781"},"PeriodicalIF":0.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11472280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In Vitro</i> Alpha-Glucosidase Inhibitory Effect of <i>Etlingera Elatior</i> Ethanol Extract Growing in Gayo Highland, Aceh Province, Indonesia.","authors":"Zumaidar Zumaidar, Nuzul Asmilia, Saudah Saudah, Milda Husnah","doi":"10.12688/f1000research.149029.2","DOIUrl":"10.12688/f1000research.149029.2","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of diabetes mellitus (DM) is increasing overtime, potentially leading to various severe health complications and mortality. Despite therapeutic agents have currently been developed, unexpected adverse effects are inevitable. Hence, safe and effective medications such as those of plant origin are critical to prevent unexpected complication in DM sufferers. <i>Etlingera elatior</i> has been widely used as spice and traditional medicine to treat diabetes in Aceh Province, Indonesia. However, study regarding α-glucosidase inhibitory effect of <i>E. elatior</i> growing in Gayo highlands, Aceh, Indonesia, is completely lacking. The aim of this study was to evaluate <i>in vitro</i> α-glucosidase inhibitory effect of <i>E. elatior</i> ethanol extracts (EEEE) growing in Gayo highlands, Aceh Province, Indonesia.</p><p><strong>Methods: </strong>Antioxidant activity was determined using DPPH procedure, whereas α-glucosidase inhibition assay was carried out using spectrophotometric method. Data analysis was performed using One-Way Analysis of Variance (ANOVA), followed by Duncan's multiple range test at α=0.05.</p><p><strong>Results: </strong>Phytochemical analysis revealed the presence of total phenolic (TPC), total flavonoid (TFC), and total tannin (TTC) content in all <i>E. elatior</i> plant parts, in which the highest TPC was found in the stem (158.38 GAE/g), whereas the highest TFC and TTC was obtained in the rhizome extracts. The extract of fruit showed the strongest antioxidant activities, followed by the stem and leaf, with IC ₅₀ of 2.381 μg/mL, 6.966 μg/mL, and 19.365 μg/mL, respectively. All <i>E. elatior</i> extracts revealed a significant inhibitory activity against α-glucosidase at the concentration of 500 μg/mL, in which the stem extract showed the most effective α-glucosidase inhibitory effect with IC ₅₀ value of 5.15 μg/mL, suggesting its promising potential as antidiabetic agent.</p><p><strong>Conclusions: </strong>This study highlights <i>E. elatior</i> potency as a novel source of antioxidant and natural antidiabetic compounds that are useful for the prevention and treatment of diabetes.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"489"},"PeriodicalIF":0.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The rise of pathogen genomics in Africa.","authors":"Gerald Mboowa, Francis Kakooza, Moses Egesa, Stephen Tukwasibwe, Stephen Kanyerezi, Ivan Sserwadda, Benson R Kidenya, Jupiter Marina Kabahita, Maria Magdalene Namaganda, Mike Nsubuga, Patricia Nabisubi, Alisen Ayitewala, Grace Kebirungi, Esther Nakafu, Natasha Patience Akwii","doi":"10.12688/f1000research.147114.2","DOIUrl":"10.12688/f1000research.147114.2","url":null,"abstract":"<p><p>The routine genomic surveillance of pathogens in diverse geographical settings and equitable data sharing are critical to inform effective infection control and therapeutic development. The coronavirus disease 2019 (COVID-19) pandemic highlighted the importance of routine genomic surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to detect emerging variants of concern. However, the majority of high-income countries sequenced >0.5% of their COVID-19 cases, unlike low- and middle-income countries. By the end of 2022, many countries around the world had managed to establish capacity for pathogen genomic surveillance. Notably, Beta and Omicron; 2 of the 5 current SARS-CoV-2 variants of concern were first discovered in Africa through an aggressive sequencing campaign led by African scientists. To sustain such infrastructure and expertise beyond this pandemic, other endemic pathogens should leverage this investment. Therefore, countries are establishing multi-pathogen genomic surveillance strategies. Here we provide a catalog of the current landscape of sequenced and publicly shared pathogens in different countries in Africa. Drawing upon our collective knowledge and expertise, we review the ever-evolving challenges and propose innovative recommendations.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"468"},"PeriodicalIF":0.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11512136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility Study of Community-Based Training for Musculoskeletal Health Promotion.","authors":"Rizky Suganda Prawiradilaga, Magnus Bendtsen, Simon Esrup, Niklas Rye Jørgensen, Fajar Awalia Yulianto, Eva Wulff Helge","doi":"10.12688/f1000research.73698.3","DOIUrl":"https://doi.org/10.12688/f1000research.73698.3","url":null,"abstract":"<p><p><b>Background:</b> To minimize fracture risk, multimodal training regimens are recommended. However, their effectiveness in community settings remains uncertain. This study evaluated the feasibility of 19-weeks of multimodal training in a local community center with emphasis on musculoskeletal health in postmenopausal women. <b>Methods:</b> In a controlled trial, 28 postmenopausal women (53-68-years-old) were assigned to a multimodal training group (MMT, n=15) or a control group (CON, n=13). The training consisted of high- and odd-impact, resistance and balance-coordination training 1-2 hours weekly. The outcomes were attendance rate, regional and total bone mineral density (BMD), bone mineral content (BMC), bone turnover markers (BTM), body composition, functional muscle strength and power, and dynamic balance. All were determined at baseline and after 19 weeks of training. BTM was assessed after three weeks. <b>Results:</b> Overall, 22(79%) participants (MMT, n=9; CON, n=13) completed the study, and the mean attendance rate for MMT was 65.5% of the maximum sessions (2) offered. Only right trochanter BMD increased (p<0.05) by 1.0±1.1% in MMT, which was higher(p<0.05) than CON. While whole-body BMC was not changed at 19 weeks from baseline in MMT, it decreased (p<0.05) in CON resulting in a significant difference (p<0.05) in whole-body BMC delta values between the two groups. Compared to baseline, body fat percentage(%BF), fat mass(FM), and visceral adipose tissue (VAT)-mass and -volume were decreased (p<0.01) in MMT, and were larger (p<0.05) than CON. No significant changes were observed in BTM, muscle strength and power, and dynamic balance after 19 weeks. <b>Conclusions:</b> Nineteen weeks of multimodal training 1-2 hours per week in a local community had a health-enhancing effect on %BF, FM, and VAT, whereas the musculoskeletal health impact was modest. We hypothesize that the reason might be too low training volume and frequency and supposedly too low musculoskeletal training intensity for some participants. <b>Registration:</b> ClinicalTrials.gov NCT05164679 (21/12/2021).</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"11 ","pages":"51"},"PeriodicalIF":0.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11387933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Teaching critical thinking about health information and choices in secondary schools: human-centred design of digital resources.","authors":"Sarah Rosenbaum, Jenny Moberg, Faith Chesire, Michael Mugisha, Ronald Ssenyonga, Marlyn A Ochieng, Clarisse Marie Claudine Simbi, Esther Nakyejwe, Benson Ngatia, Gabriel Rada, Juan Vásquez-Laval, José Damián Garrido, Grace Baguma, Sam Kuloba, Edward Sebukyu, Richard Kabanda, Irene Mwenyango, Tonny Muzaale, Pamela Nandi, Jane Njue, Cyril Oyuga, Florian Rutiyomba, Felecien Rugengamanzi, Joan Murungi, Allen Nsangi, Daniel Semakula, Margaret Kaseje, Nelson Sewankambo, Laetitia Nyirazinyoye, Simon Lewin, Andrew D Oxman, Matt Oxman","doi":"10.12688/f1000research.132580.3","DOIUrl":"10.12688/f1000research.132580.3","url":null,"abstract":"<p><strong>Background: </strong>Learning to thinking critically about health information and choices can protect people from unnecessary suffering, harm, and resource waste. Earlier work revealed that children can learn these skills, but printing costs and curricula compatibility remain important barriers to school implementation. We aimed to develop a set of digital learning resources for students to think critically about health that were suitable for use in Kenyan, Rwandan, and Ugandan secondary schools.</p><p><strong>Methods: </strong>We conducted work in two phases collaborating with teachers, students, schools, and national curriculum development offices using a human-centred design approach. First, we conducted context analyses and an overview of teaching strategies, prioritised content and collected examples. Next, we developed lessons and guidance iteratively, informed by data from user-testing, individual and group interviews, and school pilots.</p><p><strong>Results: </strong>Final resources include online lesson plans, teachers' guide, and extra resources, with lesson plans in two modes, for use in a classroom equipped with a blackboard/flip-chart and a projector. The resources are accessible offline for use when electricity or Internet is lacking. Teachers preferred the projector mode, as it provided structure and a focal point for class attention. Feedback was largely positive, with teachers and students appreciating the learning and experiencing it as relevant. Four main challenges included time to teach lessons; incorrect comprehension; identifying suitable examples; and technical, logistical, and behavioural challenges with a student-computer mode that we piloted. We resolved challenges by simplifying and combining lessons; increasing opportunities for review and assessment; developing teacher training materials, creating a searchable set of examples; and deactivating the student-computer mode.</p><p><strong>Conclusion: </strong>Using a human-centred design approach, we created digital resources for teaching secondary school students to think critically about health actions and for training teachers. Be smart about your health resources are open access and can be translated or adapted to other settings.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"12 ","pages":"481"},"PeriodicalIF":0.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142153542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring antioxidant potential of agricultural by-products: a systematic review.","authors":"Imam Santoso, Suprayogi Suprayogi, Akhmad Adi Sulianto, Endrika Widyastuti, Annisa'U Choirun, Khairunnisa Lestari, Syairil A'yuniah, Octavia Widyastuti Kusumaningtyas","doi":"10.12688/f1000research.145702.1","DOIUrl":"https://doi.org/10.12688/f1000research.145702.1","url":null,"abstract":"<p><strong>Background: </strong>Agricultural waste sourced from various activities that occur along the agricultural supply chain including post-harvest, processing, and consumption processes, can pose a threat to ecosystem balance and community welfare. Data shows that agricultural by-products have the potential to be utilized because they contain antioxidant compounds. This systematic review study aims to identify and assess the antioxidant activity of agricultural by-products through various extraction methods.</p><p><strong>Methods: </strong>This systematic review collected literature in the last 10 years (2013-2023) from Google Scholar, Semantic, and Scopus-indexed articles with the help of Publish or Perish. Using the help of boolean operators (AND) and (OR) in searching using keywords. The steps applied adapt the PRISMA method (Preferred Reporting Items for Systematic Reviews and Meta-Analyses), including identification, screening, eligibility, and inclusion.</p><p><strong>Results: </strong>Literature collection data shows that the dominant processing method used is the solvent extraction method to determine the antioxidant value of various agricultural waste by-products. Followed by microwave-assisted extraction (MAE) and ultrasound-assisted extraction (UAE) methods. A wide range of antioxidant activity values were found depending on the type of agricultural waste and processing technique. One potential utilization of agricultural wastes rich in antioxidant content is as additives in formulations in the cosmetic industry.</p><p><strong>Conclusion: </strong>Agricultural waste by-products have high potential of antioxidant content, depending on the type of waste and extraction method. The dominant agricultural waste used is by-products from the fruit group. The utilization of agricultural waste that is rich in antioxidants has the potential to be utilized in the cosmetic industry.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1008"},"PeriodicalIF":0.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11474157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}