F1000Research最新文献

{"title":"Molecular docking studies and molecular dynamic simulation analysis: To identify novel ATP-competitive inhibition of Glycogen synthase kinase-3β for Alzheimer’s disease","authors":"Suggala Ramya Shri, Yogendra Nayak, Sreedhara Ranganath Pai","doi":"10.12688/f1000research.145391.1","DOIUrl":"https://doi.org/10.12688/f1000research.145391.1","url":null,"abstract":"Background The discovery of an ideal and effective therapy is urgently required for the treatment of Alzheimer’s disease. The main pathological hallmarks of Alzheimer’s disease that appear before the clinical symptoms are neurofibrillary tangles, amyloid plaques, brain inflammation, and neuronal atrophy throughout the cerebral cortex and hippocampus. GSK-3β (Glycogen Synthase Kinase-3β) is regarded as the most important and promising target for therapeutic use because GSK-3β expression levels increase with age and are the most abundant and hyperactive in the brains of patients with Alzheimer’s disease. Methods We used Maestro, which is Schrodinger, for our computational simulation studies. In the present work, we have used different modules that were used in previous studies with a little modification, the modules such as Protein Preparation with the help of Protein Preparation Wizard, Ligand Preparation with the help of LigPrep, for ADME (Absorption, Distribution, Metabolism and Excretion) prediction we used Qikprop, Docking studies we used Glide module, Binding energy prediction we used Prime and Molecular dynamic simulation studies by Desmond Results Our focus is mainly on an in-silico approach, focusing on library generation; we first drew an imidazo [1,5-a]pyridine-3-carboxamide (IMID 2) scaffold structure at Enamine and subjected it to a substructure search to target the receptor grid region (ATP-competitive site) of 6Y9R. They were then subjected to various screening processes. Finally, we selected nine compounds and subjected them to molecular dynamic simulation studies. Conclusions Nine compounds showed good results with the most stable interactions. Further experiments and studies are required to confirm these results.","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141670241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital well-being in children and youth: Protocol for a comprehensive systematic review of reviews on interventions of problematic digital technology use","authors":"Jing Shi, Jerome Jie Ming Tan, Hwee En Ong, Dahlia Aljuboori, S. Alomairah, Michelle Colder Carras, Johannes Thrul","doi":"10.12688/f1000research.149317.1","DOIUrl":"https://doi.org/10.12688/f1000research.149317.1","url":null,"abstract":"Background Digital technologies proliferate in many people’s lives around the world with over 65% of these technology users being online. Children and youth are among the most prominent adopters of digital technologies in forms such as video gaming, social media, and online shopping. Problematic use of digital technologies can lead to poorer school/work performance, neglect of self-care skills, and comorbidities with other mental health issues. However, when used non-problematically, digital technology can also contribute to improving health and well-being. With the abundance of literature published, many reviews have sought to collate literature on treatment and interventions for children and youth with varying results. Thus, our proposed systematic review aims to synthesize current systematic reviews and meta-analyses on interventions and treatment of problematic digital technology use in children and youth (up to 25 years old). Methods As part of a three-paper series, a systematic search was completed in PsycINFO, Web of Science, and PubMed databases. Grey literature databases of the World Health Organization (IRIS database) and ClinicalTrials.gov were also searched. Furthermore, hand-searching of reference lists was also conducted. Title and abstract screening, followed by full-text screening, were completed by at least two independent reviewers. For this review, the extractions and the quality of selected reviews will be assessed using AMSTAR 2.0 by two authors independently and reviewed by two additional authors. Results Results will be presented in narrative and tabular form. The results of this study are expected to offer insights into the populations of children and youth studied, treatments/interventions provided, outcomes, results, limitations, and conclusions of literature from the past five years. Feasibility and generalizability of the reviews will also be discussed. Conclusions Methodological strengths and weaknesses of reviewed studies will point to gaps in knowledge and can be used to inform future areas of policy and research.","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141668758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Photobiomodulation improves shoulder functionality after acute traumatic anterior dislocation associated with Hill-Sachs bone lesion’","authors":"Rosani Teresa de Siqueira, Luiz Claudio de Freitas, Thomas Stravinskas Durigon, L. Motta, S. Bussadori, A. Horliana, R. Mesquita‐Ferrari, Aldo Brugnera Júnior, K. Fernandes, Cinthya Cosme Gutierrez Duran","doi":"10.12688/f1000research.152487.1","DOIUrl":"https://doi.org/10.12688/f1000research.152487.1","url":null,"abstract":"Photobiomodulation (PBM) has demonstrated positive effects on bone healing after fracture. This case report describes a skateboard-related shoulder anterior dislocation with Bankart and Hill-Sachs lesions. After a non-invasive reduction, the patient received conservative treatment with PBM. PBM was started on the accident day and continued daily for 30 days, followed by bi-weekly irradiation for 33 months. In the initial 30 days, the patient’s pain decreased, and the shoulder function was recovered with no pain, swelling, or bruising. On day 28, there was a reduction in edema compared to the initial injury and a full shoulder recovery for daily and sports activities. Physical examinations confirmed shoulder joint stability and the images at 33 months demonstrated Hill-Sachs lesion healing and significant Bankart lesion repair. In conclusion, PBM can induce recovery, alleviate pain, and facilitate functional rehabilitation. Additional clinical trials are required to validate the efficacy of this complementary therapy.","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141667013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis and Molecular Characterization of Dermatophytosis: An Observational Study","authors":"Aditi Warghade, G. Mudey","doi":"10.12688/f1000research.141657.2","DOIUrl":"https://doi.org/10.12688/f1000research.141657.2","url":null,"abstract":"Dermatophytes are the keratinophilic fungi which infect humans and is the most recurring type of disease. The high level of transmissibility creates an epidemiological risk and emphasises the significance of these illnesses. However, a growing number of reports describing dermatophytes can cause deep infections in diabetic and immunocompromised patients, by invading deep layers like the dermis and hypodermis. Despite the prevalence and significance of dermatophytes in clinical mycology, it is not always possible to accurately diagnose this specific infection due to its overlapping structures among species of dermatophytes. Since it is difficult to identify species that exhibit weak characteristics in the morphological highlights, identification of the dermatophyte is often relied on its morphological analysis, which is a laborious process and demands skill. The massive shift in genetic variation, the source of infection, and epidemiological research can be discovered using molecular approaches. Therefore, the development of an accurate laboratory test for dermatophyte species identification is essential for the prevention and efficient management of dermatophytoses. One such methodology allows use of PCR technology which has many methods for molecular level characterization which is rapid, efficient, and capable of producing DNA polymorphisms specific to various dermatophyte species based on distinctive band patterns seen by agarose gel electrophoresis. The RAPD-PCR approach will be used in this study protocol to molecularly characterize the dermatophytes for precise speciation of the sample. In addition to improving knowledge of fungal biology and pathology with a focus on adaptive mechanisms to combat difficult conditions from host counteractions, there is a need to improve awareness of the importance of these diseases through accurate epidemiological data. The advantages of molecular approaches for characterizing objects over traditional methods are their sensitivity and specificity.","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141667299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristic min-polynomial of a triangular and diagonal strictly double R-astic matrices","authors":"Siswanto Siswanto, Sahmura Maula Al Maghribi","doi":"10.12688/f1000research.147931.1","DOIUrl":"https://doi.org/10.12688/f1000research.147931.1","url":null,"abstract":"Background Determinant and characteristic polynomials are important concepts related to square matrices. Due to the absence of additive inverse in max-plus algebra, the determinant of a matrix over max-plus algebra can be represented by a permanent. In addition, there are several types of square matrices over max-plus algebra, including triangular and diagonal strictly double ℝ -astic matrices. A special formula has been devised to determine the permanent and characteristic max-polynomial of those matrices. Another algebraic structure that is isomorphic with max-plus algebra is min-plus algebra. Methods Min-plus algebra is the algebraic structure of triple ( ℝ ε ′ , ⊕ ′ , ⊗ ) . Furthermore, square matrices over min plus algebra are defined by the set of matrices sized n × n , the entries of which are the elements of ℝ ε ′ . Because these two algebraic structures are isomorphic, the permanent and characteristic min-polynomial can also be determined for each square matrix over min-plus algebra, as well as the types of matrices. Results In this paper, we find out the special formulas for determining the permanent and characteristic min-polynomial of the triangular matrix and the diagonal strictly double ℝ -astic matrix. Conclusions We show that the formula for determining the characteristic min-polynomial of the two matrices is the same, for each triangular matrix and strictly double ℝ -astic matrix A , χ A ( x ) = ⨁ r = 0 , 1 , … , n ′ δ n − r ⊗ n r .","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141667046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated Management of Hazardous Solid Waste in Dental Offices of Talara (Peru) and Machala (Ecuador): A Policy Brief Comparing Two Latin American Countries","authors":"María Elizabet Cruz Ramos, Jeiner Javier Salvatierra Chuquimarca, L. A. Orrego-Ferreyros","doi":"10.12688/f1000research.152652.1","DOIUrl":"https://doi.org/10.12688/f1000research.152652.1","url":null,"abstract":"Background The improper management of hazardous solid waste in dental care offices poses significant risks to public health and the environment. Dental offices generate hazardous waste, including biological and chemical contaminants, which can lead to infections, pollution, and harm if not managed properly. Effective waste management practices are crucial, yet compliance varies significantly across regions, especially in Latin America, due to limited resources, inadequate training, and insufficient infrastructure. This study compares hazardous waste management practices in dental offices in Talara, Peru, and Machala, Ecuador, to provide actionable recommendations for improvement. Policy and Implications In Peru, hazardous waste management involves critical steps such as conditioning, segregation, transport, storage, treatment, and disposal. Compliance minimizes exposure risks and environmental contamination. Ecuador emphasizes administrative and operational aspects, including policies, records, training, and procedures. Improving practices in both countries can model enhanced waste management across Latin America. Recommendations To address challenges in Talara and similar Latin American cities, it is essential to strengthen administrative systems, increase budget allocations for waste management, and develop comprehensive training programs. Waste management should be prioritized within public policy agendas with clear guidelines and accountability measures. Both cities need improved resource allocation, modern waste treatment facilities, and centralized storage solutions. Continuous education and certification programs are crucial. Implementing integrated policies, regular reviews, and robust compliance mechanisms based on Machala’s practices can benefit other regions. Public awareness campaigns and regional collaboration through workshops and research initiatives are also recommended. Conclusions Significant disparities in hazardous waste management exist between Talara and Machala. Talara requires strengthened systems and improved infrastructure, while Machala’s practices serve as a model. Tailored interventions can enhance public health and environmental outcomes across Latin America. Regular monitoring, evaluation, and collaboration are essential for sustained improvements.","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141668267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proposing an Effective Waqf Model for Ensuring Poverty Reduction among Refugees in Malaysia","authors":"Adnan Opeyemi Salaudeen","doi":"10.12688/f1000research.149944.1","DOIUrl":"https://doi.org/10.12688/f1000research.149944.1","url":null,"abstract":"Background COVID-19 has heavily impacted the financial and economic well-being of the world’s population. Various national relief programs and initiatives have been carried out to address society’s financial difficulties, especially the issue of poverty among the vulnerable, like refugees and immigrants. Consequently, being one of the main elements in Islamic social finance, waqf has been emphasised and proven throughout Islamic history as one of the practical tools for poverty reduction. However, recent waqf initiatives towards poverty reduction focused more on aiding the micro and small entrepreneurs, whilst limited waqf initiatives were available to help low-income households, refugees, and immigrants during this critical time in Malaysia. Methods This study introduces a novel waqf model, specifically designed to contribute to poverty reduction in society. It is tailored for low-income households, refugees, and immigrants, aiming to sustain their financial independence. By combining the elements of waqf and crowdfunding, this model proposes an innovative agriculture-based microfinance programme. It utilizes undeveloped waqf lands and equity-based crowdfunding to reach its objective of poverty reduction. This study has adopted a secondary research approach using the existing scholarly literature. Results This paper also discusses the potential of the proposed model to deliver more than its primary objective, as the framework illustrates that waqf institutions will have a continuous inflow of funds that will allow them to initiate other waqf-based projects, job creation through the microfinance programmes, and financial return for the investor of equity-based crowdfunding projects. Conclusion This study not only underscores the sustainability of the proposed model, but also its alignment with the increasing awareness of value-based and social impact objectives. It further explores the potential of waqf to be integrated with other financing instruments during the pandemic to help the vulnerable, specifically refugees and immigrants. This research thus contributes to the true purpose of Islamic social finance, highlighting the significance of its findings.","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141669415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tuberculosis Case Finding Using Self-Assessment Paradigm Through the E-TIBI Application in HIV Patients","authors":"E. Triyono, Merita Arini, Feriawan Tan, Lilis Masyfufah","doi":"10.12688/f1000research.152632.1","DOIUrl":"https://doi.org/10.12688/f1000research.152632.1","url":null,"abstract":"Background The goal of eliminating tuberculosis has not yet shown a bright spot. Specifically for HIV patients (PLHIV), WHO has made it a special category as a pillar for eliminating tuberculosis. The tuberculosis screening has not yet reached the national target because it is carried out manually by health workers, requiring optimization following technological developments. This study aims to determine the effectiveness of tuberculosis case finding using a self-assessment paradigm in HIV patients. Methods This research was cross-sectional. The data obtained from HIV patients before and after using the E-TIBI application for 3 months each was analyzed using the compare mean independent t-test. Then the Chi-squared test was carried out on the E-TIBI screening characteristic variables. Result In total, there were 921 respondents with 148 (16%) presumptive TB. It was found that there was a significant difference (p<0.05) in the number of presumptive TB cases found in HIV patients before and after using the E-TIBI application. The person with presumptive TB showed 20 of 24 characteristic variables that were statistically significant (p<0.05). Conclusion E-TIBI can increase the tuberculosis case finding in HIV patients so it has the potential to be implemented as a screening tool in the PLHIV community.","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141673457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Planet activeness: a new concept to enhance the accuracy of Astromet weather forecast.","authors":"Dheebakaran Ga, K. S, Santosh Ganapati Patil, S. T, Rathika K, Arul Prasath S, Balamurali B, Sathyamoorthy N.K.","doi":"10.12688/f1000research.149941.1","DOIUrl":"https://doi.org/10.12688/f1000research.149941.1","url":null,"abstract":"Background Astrometeorology is an ancient science, that deals the relationship between planet position and weather events. Several Indian studies proved that Astrometeorology could be a complementary method to improve numerical weather forecast accuracy. Since 2011, Tamil Nadu Agricultural University is conducting astrometeorological research and devised a novel concept “Planet Activeness Chart”. The principle is that “planets’ influence on a location’s weather varies throughout the day and may be negative, inactive, active, highly active and rule depending on their angle to that location”. Most existing astromet studies used planetary position to predict the occurrence of weather events (yes/no) but failed to capture intensity of the event. The “Planet Activeness Concept” could address this limitation and enhance forecast usability. Methods A study was carried out from 2018 to 2021 with six years data (2011-16) to verify the “Planet activeness” on hourly rainfall and windspeed events in Tamil Nadu. The frequency of planet activeness for a weather event was calculated by dividing the number of times a planet was in the selected activeness during a specific event category by the total number of events. Results The results indicated that negative state of the Sun, active status of the Saturn, Uranus, Venus and Moon were positively associated with rainfall intensity. The windy planet Mercury and Neptune at active state, the Sun and Saturn at rule state, Venus and Uranus at negative state, Jupiter at highly active state had significant influence on the increased wind speed. Conclusion Applying the planet activeness concept with azimuth could enhance the accuracy and usability of Astrometeorological forecasts. This study establishes a mathematical relationship between planet activeness and weather as a first step to understand the science behind this relationship. It is suggested to study different combination of planet activeness during a weather event for more insights.","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141675841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural agents that are neuroprotective against mitochondria: a bibliometric-based research mapping 1998–2024, from cells to mitochondria","authors":"Arman YURISALDI SALEH, Dwi Arwandi Yogi Saputra","doi":"10.12688/f1000research.151380.1","DOIUrl":"https://doi.org/10.12688/f1000research.151380.1","url":null,"abstract":"Introduction Mitochondria are cell organelles that function as the cell’s main power plant, producing ATP, the main energy molecule in cells. Mitochondria play an important role in the context of neuroprotection, and mitochondrial function has been implicated in various neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and amyotrophic lateral sclerosis (ALS). Recent research in the field of neuroprotection has focused on the development of therapies that target mitochondria. Natural ingredients have long been used in traditional medicine and show potential as neuroprotective agents. Methods In this work, a literature review methodology is employed to gather data from the Scopus database using the keywords natural agents, herb*, neuroprotective, and mitochondria. The data were analyzed using Biblioshiny and VOSviewer software to produce visualizations and bibliometric maps. We conducted quantitative and qualitative analyses. Results The research trend found are documents by year, most global cited document, most relevant sources, A factorial map illustrating the leading contributors of papers, documents by author, documents by country or territory, documents by subject area, network visualization, overlay visualization of scopus database using vosviewer, density visualization, thematic map, thematic evolution, cluster analysis, qualitative analysis, and word cloud. Conclusions Natural Agent Neurotropik is a natural substance that influences the brain’s nervous system and peripheral nervous system, enhancing cognition, mood, and brain function. Derived from herbs, spices, and herbal products, it has advantages over other natural agents in energy production, brain biogenesis, and neuroprotection.","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141674163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}