F1000Research最新文献

{"title":"Influencing factors of health-related quality-of-life perceived by both children/adolescents patients with type-1 diabetes mellitus and their parents: A North-African study.","authors":"Imen Ben Abdesselem, Raoudha Kebeili, Khansa Derbel, Hichem Ben Said, Lamia Boughamoura, Jihene Bouguila, Helmi Ben Saad","doi":"10.12688/f1000research.148074.1","DOIUrl":"10.12688/f1000research.148074.1","url":null,"abstract":"<p><strong>Aim: </strong>To determine the influencing factors of health-related quality-of-life (HRQoL) perceived by North-African children/adolescents with type-1 diabetes-mellitus (T1DM) and their parents.</p><p><strong>Methods: </strong>It was a cross sectional study conducted in Tunisia. A total of 116 patients ( <b><i>ie</i></b> ; 43 children and 73 adolescents) and their parents were included. The Arabic validated version of the Pediatric Generic Core Quality-of-Life Inventory 4.0-Scale (PedsQL4.0) was used to evaluate the HRQoL of children/adolescents as perceived by patients and parents. The dependent data were the patients' self-report and the parents' proxy-report of the PedsQL4.0 total scores, and the independent data were the patients and parents characteristics.</p><p><strong>Results: </strong>Patients' PedsQL4.0 total score was influenced significantly by siblings in the family > 2; lipodystrophy, and glycosylated hemoglobin (HbA1C). The combination of these factors explained 34.84% of the PedsQL4.0 total score variability. Parents' PedsQL4.0 total score was influenced significantly by lipodystrophy, siblings; body mass index (BMI), hypoglycemia episodes, and HbA1C. The combination of these factors explained 56.92% of the PedsQL4.0 total score variability.</p><p><strong>Conclusion: </strong>T1DM patients self-reported HRQoL was influenced by siblings in the family > 2; lipodystrophy, and HbA1C. The parents' proxy-report HRQoL was influenced by lipodystrophy, siblings, BMI, hypoglycemia episodes, and HbA1C.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"429"},"PeriodicalIF":0.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic and Prognostic Values of miRNAs in High-Grade Gliomas: A Systematic Review.","authors":"Renindra Ananda Aman, Mohammad Galih Pratama, Ricky Rusydi Satriawan, Irfani Ryan Ardiansyah, I Ketut Agus Suanjaya","doi":"10.12688/f1000research.151350.2","DOIUrl":"10.12688/f1000research.151350.2","url":null,"abstract":"<p><strong>Background: </strong>Gliomas, particularly glioblastomas, have grim prognoses, necessitating early diagnostic and prognostic indicators. MicroRNAs (miRNAs), influential in cancer research, show potential as glioma biomarkers. This systematic review aimed to examine the efficacy of miRNAs in the diagnosis and prognosis of high-grade glioma.</p><p><strong>Methods: </strong>A comprehensive search was conducted of PubMed, EMBASE, Cochrane Library, and Web of Science for studies published from 2013 to 2023. The eligibility criteria included high-grade glioma, histopathological confirmation, miRNA samples from cerebrospinal fluid or plasma, and relevant outcome data. Studies were excluded if they were experimental or reviews and not in English.</p><p><strong>Results: </strong>Of the 1120 initial results, 8 studies involving 660 subjects met the inclusion criteria. Several studies have assessed miRNA expression and its association with diagnosis and prognosis of high-grade gliomas. Overexpression of miR-221, miR-222, miR-210, miR-21, miR-125b, and miR-223 and under-expression of miR-15b and miR-124-3p showed significant potential in differentiating high-grade glioma patients from controls. Additionally, miRNAs are associated with distinct tumorigenic pathways.</p><p><strong>Conclusion: </strong>Elevated or depressed expression levels of specific circulating miRNAs hold significant promise as noninvasive biomarkers for the diagnosis and prognosis of high-grade glioma. These miRNAs offer valuable insights into disease progression and patient outcome. Further validation through extensive clinical trials and in-depth mechanistic studies is essential to realize their full clinical utility.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"796"},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11826073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CYP2C19 polymorphism and coronary in-stent restenosis: A systematic review and meta-analysis.","authors":"Yusra Pintaningrum, Vitriyaturrida, Ivana Purnama Dewi, Hendy Bhaskara Perdana Putra, Idar Mappangara, Muzakkir Amir, Irawan Yusuf, Agussalim Bukhari","doi":"10.12688/f1000research.109321.2","DOIUrl":"10.12688/f1000research.109321.2","url":null,"abstract":"<p><strong>Background: </strong>In-stent restenosis (ISR) remains a major drawback in coronary stenting. The association between the CYP2C19 loss of function (LOF) gene and the prevalence of ISR after coronary stenting remains controversial. Previous studies have produced conflicting results and have been limited by their small population sizes. We conducted this systematic review and meta-analysis to determine the association between the presence of the CYP2C19 LOF gene and the prevalence of ISR.</p><p><strong>Methods: </strong>A systematic online database search was performed until April 2021. The primary outcome was ISR and assessed using OR with 95% CI. Quality of the study was assessed using the Newcastle Ottawa Scale. <i>I ²</i> was applied to examine heterogeneities among the studies.</p><p><strong>Results: </strong>A total of 284 patients (four non-randomized controlled trial studies) were included in this study. Two hundred and six patients had wild-type genotypes, while 78 patients had the LOF genotype. Among the 78 patients with the LOF gene, 38 patients had an ISR. Meanwhile, of the 206 patients with a wild-type gene, 69 patients had an ISR. LOF gene was associated with a higher risk of ISR (OR 95% CI = 2.71 [1.42-5.16], P = 0.003). However, study-specific variability should be considered when applying these findings clinically.</p><p><strong>Conclusions: </strong>Patients with LOF genes, regardless of the allele variation, treated with clopidogrel, had a higher likelihood of ISR after coronary stenting.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"11 ","pages":"346"},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11078198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140893179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of hydrolyzed red worm ( <i>Eisenia foétida</i>) on production parameters in red tilapia ( <i>Oreochromis sp.</i>).","authors":"Fabian Gerardo Muñoz García, Nelson Vivas Quila, Luis Fernando Londoño Franco, Crispulo Perea Roman, José Luis Hoyos Concha","doi":"10.12688/f1000research.154622.1","DOIUrl":"10.12688/f1000research.154622.1","url":null,"abstract":"<p><strong>Background: </strong>Conventional fish feed based on fish meal, meat, and soy cake presents procurement difficulties and high costs, affecting the profitability and sustainability of the aquaculture industry.</p><p><strong>Objective: </strong>To evaluate the effect of hydrolyzed red worm (HRW- <i>Eisenia foétida</i>) in red tilapia ( <i>Oreochromis sp.</i>) diet on production parameters.</p><p><strong>Methods: </strong>The study was conducted at the aquaculture farm of the Politécnico Colombiano Jaime Isaza Cadavid (PCJIC) at 780 m.a.s.l.,with an average temperature of 28 °C. Ninety red tilapia fingerlings, averaging 7,5±0,5 g, were distributed in nine aquariums containing 75 liters of water. Fish underwentweight and size measurements at the beginning and end of the trial. They were fed experimental diets to apparent satiation three times daily. Water quality parameters and productive rates of growth and nutrient utilization were measured. The experimental design included three treatments with three replicates each: T1 (control diet, 0% hydrolysate inclusion), T2 (10% hydrolysate inclusion), and T3 (20% hydrolysate inclusion). ANOVA (p<0,05) was applied to growth and nutrient utilization variables, with mean comparisons using α<0,05 in SPSS version 25.</p><p><strong>Results: </strong>Significant differences (p<0,04) were found between the control diet T1 (0% inclusion) and T2 (10% inclusion) in favor of weight gain (31,87 g). There were no statistical differences in size increase (p<0,217). As HRWinclusion increased, feed consumption decreased, likely due to higher hydrolyzed protein availability. Feed conversion rates showed significant differences (p<0,001) between T2 and T3 compared to T1, indicating better assimilation of the hydrolyzed protein. T2 and T3 also showed better protein and energy efficiency (p<0,001), demonstrating the hydrolyzed protein's nutritional quality and assimilation. Diet cost decreased with higher hydrolyzed inclusion (p<0,034).</p><p><strong>Conclusion: </strong>Inclusion 10% and 20% hydrolyzed red worms significantly improved production parameters and reduced costs, making it a viable alternative for feeding red tilapia for small and medium-scale producers.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"90"},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alternative dispute resolution: Mediation as a model.","authors":"Naser Sherman, Bashar Talal Momani","doi":"10.12688/f1000research.152362.2","DOIUrl":"https://doi.org/10.12688/f1000research.152362.2","url":null,"abstract":"<p><strong>Background: </strong>The topic of Alternative Dispute Resolution (ADR) in civil and commercial contexts presents a contemporary legal challenge aimed at fostering equitable solutions. Among ADR methods, mediation stands out for its ability to reduce time, costs, and litigation duration. This study explores the conceptual framework, essential conditions, and procedural aspects of mediation. It evaluates the sufficiency, regulation, and effectiveness of mediation principles in conflict resolution and risk mitigation.</p><p><strong>Methods: </strong>This study is conducted through a comprehensive review of current literature on Alternative Dispute Resolution methods, with a particular focus on mediation as an alternative to dispute settlement. The study utilizes qualitative analysis techniques to examine the effectiveness of mediation principles and their application in resolving civil and commercial disputes. Comparative analyses are also conducted to extract useful insights from various legal systems and authorities.</p><p><strong>Results: </strong>The study provides an analysis that illustrates the effectiveness of mediation in resolving disputes, emphasizing its potential benefits in terms of time and cost savings, as well as its srole in facilitating amicable resolutions. The results of this study shall contribute to the current body of knowledge on mediation and provide practical recommendations for its application in diverse legal contexts.</p><p><strong>Conclusion: </strong>In conclusion, the study proposes strategies to enhance mediation practices, promote a culture of its adoption, and integrate it more closely into the judicial system. Additionally, it anticipates the future effectiveness of mediation in jurisdictions lacking comprehensive legislation, drawing from successful Western experiences to guide potential developments in Arab legal frameworks.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"778"},"PeriodicalIF":0.0,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11806251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melatonin: The potential avenues in dentistry.","authors":"Dr Sanidhya S, Deepa Kamath, Aradhya Sinha, Diya Kamath","doi":"10.12688/f1000research.159942.1","DOIUrl":"10.12688/f1000research.159942.1","url":null,"abstract":"<p><p>Melatonin, the \"sleep hormone,\" shows significant promise in dentistry owing to its antioxidant, anti-inflammatory, and immunomodulatory properties. It is beneficial for treating periodontal disorders and aiding osseointegration of dental implants. Additionally, melatonin helps to manage dental anxiety, offering an alternative to traditional sedatives. Periodontal disease is orchestrated by bacterial plaques along with an exaggerated immune-inflammatory host response. Treatment of periodontitis not only involves the removal of plaque, but also aims to minimize the cytokine load and control the reactive oxygen species burden in the tissues, which would re-establish a healthy periodontium and a balanced bone metabolism. Melatonin is known to exert beneficial effects, such as regulation of circadian rhythm, bone remodeling, and antimicrobial effects. Recent studies have demonstrated the successful use of melatonin as an adjunct to mechanical debridement for the treatment of periodontal disease. Its various uses include systemic administration of melatonin after one-stage full-mouth Non-Surgical Periodontal Therapy in healthy subjects as well as patients. This article provides a summary of the various clinical applications of melatonin, describing its mechanism of action, uses, and potential avenues for future research in dentistry.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"77"},"PeriodicalIF":0.0,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuronal subset-specific <i>Pten</i>-deficient mice do not exhibit deficits in sensorimotor gating processes.","authors":"Matthew S Binder, Suzanne O Nolan, Joaquin N Lugo","doi":"10.12688/f1000research.20604.3","DOIUrl":"10.12688/f1000research.20604.3","url":null,"abstract":"<p><strong>Background: </strong>Deficits in sensorimotor gating have been reported in individuals with autism spectrum disorder (ASD), as well as in ASD murine models. However, this behavior has not been examined in the neuronal subset-specific (NS)- <i>Pten</i> knockout (KO) model of ASD. <i>NS-Pten</i> KO mice exhibit hyperactivity of the PI3K/AKT/mTOR signaling pathway which is implicated in the onset of autistic deficits. This study investigates the potential relationship between PI3K/AKT/mTOR signaling and deficits in sensorimotor gating.</p><p><strong>Methods: </strong>To assess sensorimotor gating in NS- <i>Pten</i> KO mice we utilized a three-day paradigm. On day 1 (habituation) the mice were administered 80 repetitions of a 120-dB startle stimulus. On day 2, prepulse inhibition was measured with 90 trials of the startle stimulus that was paired with a smaller (2, 7, or 12 dB) prepulse stimulus. Day 3 was assessed one week later, consisting of randomized startle trials and trials with no stimulus and was used to determine the startle response.</p><p><strong>Results: </strong>No significant difference between NS- <i>Pten</i> KO or wildtype (WT) mice was found for habituation ( <i>p</i> > 0.05). No significant differences were found between groups when assessing the percentage of prepulse inhibition at 2, 7, and 12 dB ( <i>p</i> > 0.05). There was also no difference in startle response between groups ( <i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>Our study found that the NS- <i>Pten</i> KO model does not display significant deficits in sensorimotor gating processes. The present findings help to elucidate the relationship between PI3K/AKT/mTOR hyperactivation and sensory reactivity.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"8 ","pages":"1727"},"PeriodicalIF":0.0,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conditioning factors for the scientific productivity of undergraduate students of health sciences at a private Peruvian University: A cross-sectional analytical study.","authors":"César Antonio Bonilla-Asalde, Isabel Cristina Rivera-Lozada, Oriana Rivera-Lozada","doi":"10.12688/f1000research.143021.2","DOIUrl":"10.12688/f1000research.143021.2","url":null,"abstract":"<p><strong>Background: </strong>The objective of this study was to determine the conditioning factors for scientific research productivity in university students of health sciences.Scientific productivity, in addition to making visible the generation of new knowledge, contributes to the well-being of the population and provides feedback to the scientific community in terms of methodologies, perspectives and results that help to break down barriers that delimit productivity in scientific research.</p><p><strong>Methods: </strong>A cross-sectional analytical observational study was conducted. The study population was 4104 students enrolled during the 2021-I semester in the Faculty of Health Sciences of a private Peruvian university. A sample size of 400 students was determined and a stratified probability sampling was used. The variables were measured through surveys. The dependent variable was scientific research productivity, and the independent variables were institutional culture, knowledge management and technological capital. Summary measures are reported according to the type of variable. The chi-square test with a significance level of p<0.05 was applied to assess the association between the variables of interest. A multiple logistic regression analysis was performed using the Stepwise method. Prevalence ratios (PR) with their respective 95% confidence intervals (95%CI) were calculated.</p><p><strong>Results: </strong>From the total of 400 students, 74.5% were male, 57.25% were aged between 18 and 27 years, 17% belonged to the school of human medicine and 72% were in their sixth year of studies. Scientific research productivity was associated with management commitment (PR=1.493; 95%CI: 1.077-2.068, p=0.015), sense of personal growth (PR=1.632; 95%CI: 1.041-2.558; p=0.024), recognition by the university (PR=1.385; 95%CI: 1.012-1.896; p=0.043), strategic alliances (PR=1.422; 95%CI: 1.032-1.959; p=0. 03), having research proposals (PR=1.522; 95%CI: 1.114-2.08; p=0.009), dissemination of results obtained (PR=1.542; 95%CI: 1.12-2.122; p=0.01), availability of human resources (PR=1.591; 95%CI: 1.165-2.173; p=0.004), access to equipment and software (PR=1.482; 95%CI: 1.061-2.069; p=0.018) and to laboratories (PR=1.438; 95%CI: 1.047-1.974; p=0.024).</p><p><strong>Conclusion: </strong>It is concluded that the research productivity of undergraduate students of health sciences is low. It is imperative to strengthen the university research culture that empowers students as agents of change and strengthens faculty participation in scientific networks and communities.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"5"},"PeriodicalIF":0.0,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of auditory-based cognitive training on auditory resolution, executive function, and working memory skills in individuals with mild cognitive impairment - a pilot randomized controlled study.","authors":"Priya G, Kishan Mm, VaniLakshmi R, Gopee Krishnan","doi":"10.12688/f1000research.152775.2","DOIUrl":"10.12688/f1000research.152775.2","url":null,"abstract":"<p><strong>Background: </strong>Age-related central auditory processing disorder and mild cognitive impairment (MCI) can be concomitant in older adults, making it difficult to communicate, especially in challenging listening conditions. This preliminary study investigated the efficacy of auditory-based cognitive training on the auditory processing abilities and cognitive functions of older adults with MCI.</p><p><strong>Methods: </strong>In this randomized controlled trial twenty-two older adults with mild cognitive impairment (MCI) were randomly assigned to either an experimental (n=11) or a control group (n=11). The experimental group received 15 cognitive training sessions through tasks involving the auditory domain. The outcome measures of this study included auditory resolution (Temporal gap detection, frequency discrimination, and modulation detection) and cognitive measures (Trail making tests and digit recall), which were administered at three-time points (before training, post-training, and follow-up). The linear mixed model computed the effects of training on the outcome measures.</p><p><strong>Results: </strong>A significant improvement was observed in the modulation detection threshold between baseline and follow-up and between post-training and follow-up sessions. However, GDT and FD thresholds did not reveal any statistically significant difference. In the trail making test, Part B showed consistent significance across the time points, whereas Part A and the delayed recall task showed no significant difference.</p><p><strong>Conclusion: </strong>Auditory-based cognitive training may improve auditory processing and executive function in older adults with mild cognitive impairment (MCI).</p><p><strong>Trial registration: </strong>CTRI/2019/01/017073, registered on 14.01.2019.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1022"},"PeriodicalIF":0.0,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social pain: A systematic review on interventions.","authors":"Brandon M Brooks, Francisco J Cordero, Stephen L Alchermes, Bradley M Brooks","doi":"10.12688/f1000research.159561.1","DOIUrl":"10.12688/f1000research.159561.1","url":null,"abstract":"<p><p>Social pain is emotional distress caused by harm or threat to social connections that results in social exclusion, rejection, or loss. Social Pain is also a potentiator of physical pain. Supportive social relationships are widely recognized for their impact on maintaining health and well-being. The Passion of Jesus Christ serves as a quintessential example of social pain (i.e., desertion, betrayal, denial) potentiating physical pain (i.e., beatings, Crown of Thorns, crucifixion). Christ opts to forgive. Although forgiveness is one solution to reduce social pain, other interventions exist. This review seeks to identify and summarize interventions associated with reducing social pain. We conducted a systematic review using Medline (PubMed), Google Scholar, and Cochrane CENTRAL to identify relevant articles. Results: The database searches produced 548 articles. Fourteen randomized controlled trials (RCTs) were included in this systematic review. Acetaminophen, both deceptive and open-label placebos, mindfulness training, and psilocybin were found to reduce social pain. Of note, the combination of acetaminophen and forgiveness yielded superior results compared to either acetaminophen or forgiveness alone. Pharmacological interventions operate on the premise that the neural pathways responsible for physical pain also play a role in social pain. Both pharmacological and non-pharmacological interventions are available for reducing social pain.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"58"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}