F1000Research最新文献

{"title":"Geographic distribution of conversion therapy prevalence in Canada. Findings from a national cross-sectional survey, 2020.","authors":"Amrit Tiwana, Travis Salway, Julia Schillaci-Ventura, Sarah Watt","doi":"10.12688/f1000research.134292.1","DOIUrl":"10.12688/f1000research.134292.1","url":null,"abstract":"<p><strong>Background: </strong>Conversion therapy practices (CTPs) are discredited efforts that target lesbian, gay, bisexual, trans, queer, Two-Spirit, or other (LGBTQ2S+) people and seek to change, deny, or discourage their sexual orientation, gender identity, and/or gender expression. This study aims to investigate the prevalence of CTPs across Canadian provinces and territories and identify whether CTP bans reduce the prevalence of CTPs.</p><p><strong>Methods: </strong>We collected 119 CTPs from 31 adults (18+) in Canada who have direct experience with CTPs, know people who have gone to CTPs, or know of conversion therapy practitioners using a 2020 anonymous online survey. Mapping analysis was conducted using ArcGIS Online. CTP prevalence was compared between provinces/territories with and without bans using chi-square tests.</p><p><strong>Results: </strong>Three provinces and eleven municipalities had CTP bans. The prevalence of CTPs in provinces/territories with bans was 2.34 per 1,000,000 population (95% CI 1.65, 3.31). The prevalence of CTPs in provinces/territories without bans was 4.13 per 1,000,000 population (95% CI 3.32, 5.14). Accounting for the underlying population, provinces/territories with the highest prevalence of CTPs per 1,000,000 population were New Brunswick (6.69), Nova Scotia (6.50), and Saskatchewan (6.37).</p><p><strong>Conclusions: </strong>Findings suggest only 55% of Canadians were protected under CTP bans. The prevalence of CTPs in provinces/territories without bans was 1.76 times greater than provinces/territories with bans. CTPs are occurring in most provinces/territories, with higher prevalence in the west and the Atlantic. These findings and continued efforts to monitor CTP prevalence can help inform policymakers and legislators as society is increasingly acknowledging CTPs as a threat to the health and well-being of LGBTQ2S+ people.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10905130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140021298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Talent management of library and information science professionals: A review of research and future directions.","authors":"Bijayalaxmi Rautaray, Dillip K Swain, Chandrakant Swain","doi":"10.12688/f1000research.151301.2","DOIUrl":"10.12688/f1000research.151301.2","url":null,"abstract":"<p><strong>Background: </strong>This study aims to review the extant literature on talent management with the objective of influencing library and information management by addressing the key facets of talent management, such as talent management strategies, importance of career development, evaluation of talented employees, and organizational resilience.</p><p><strong>Methodology: </strong>Literature on the development of talent and career management was retrieved from various scholarly papers indexed in Scopus and Web of Science to have a meticulous literature review serving as the platform of the present study. In light of the authors' observations, two models were developed. The literature provides precise information that talent management plays a decisive role in promoting organizational excellence invariably in all kinds of organizations in general and libraries in particular.</p><p><strong>Results: </strong>This study provides constructive recommendations for the implementation of effective talent management and retention policies for library and information professionals. Moreover, this study adds immense value to the corpus of existing literature to set a platform for the augmentation of library management in futuristic vision.</p><p><strong>Conclusion: </strong>This study provides constructive recommendations to policy makers and library administrators to foster talented employees for excelling library and information services for the next several decades.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11344875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A guide to selecting high-performing antibodies for Huntingtin (UniProt ID: P42858) for use in western blot, immunoprecipitation, and immunofluorescence.","authors":"Rebeka Fanti, Riham Ayoubi, Charles Alende, Maryam Fotouhi, Sara González Bolívar, Renu Chandrasekaran, Kathleen Southern, Aled M Edwards, Rachel J Harding, Carl Laflamme","doi":"10.12688/f1000research.153670.1","DOIUrl":"10.12688/f1000research.153670.1","url":null,"abstract":"<p><p>Huntingtin encodes a 3144 amino acid protein, with a polyglutamine repeat tract at the N-terminus. Expansion of this repeat tract above a pathogenic threshold of 36 repeats is the causative mutation of Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. Here we have characterized twenty Huntingtin commercial antibodies for western blot, immunoprecipitation, and immunofluorescence using a standardized experimental protocol based on comparing read-outs in knockout cell lines and isogenic parental controls. These studies are part of a larger, collaborative initiative seeking to address antibody reproducibility issues by characterizing commercially available antibodies for human proteins and publishing the results openly as a resource for the scientific community. While use of antibodies and protocols vary between laboratories, we encourage readers to use this report as a guide to select the most appropriate antibodies for their specific needs.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11384196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cointegration and causality relationship of Indian stock market with selected world markets.","authors":"Farman Ali, Pradeep Suri, Tarunpreet Kaur, Deepa Bisht","doi":"10.12688/f1000research.123849.4","DOIUrl":"10.12688/f1000research.123849.4","url":null,"abstract":"<p><p><b>Background:</b> The purpose of this study is to explore the trends and causes of established and emerging nations' stock market integration with India. The National Stock Exchange (NSE) indices act as a counterweight to international market indices. This study investigates the sustained interest of foreign investors in the Indian stock market in the wake of capital market reforms, as well as whether it moves in tandem with other markets in Asia and the United States. <b>Methods:</b> Our study examined the possibility of cross-country cointegration between the largest economies and indices around the world using multiple financial econometric models, such as Augmented Dickey-Fuller, Unit Root, Correlation, and Johansen Cointegration. <b>Results:</b> The findings of this study significantly support the notion that Indian and international financial markets are highly integrated. Vector error correction model indicates that the Indian market (NSE) is highly cointegrated with the US market (National Association of Securities Dealers Automated Quotations) and increased volatility signifies global contagion. <b>Conclusion:</b> A cursory examination of the data reveals distinct investment and portfolio diversification options for global investors. This could assist regulators in formulating more effective rules regarding price discovery processes.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11339595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of pumice stone and silica fume as precursor material for the design of a geopolymer.","authors":"Alexis Iván Andrade Valle, Tito Oswaldo Castillo Campoverde, Cristian Andrés Marcillo Zapata, María Gabriela Zúñiga Rodríguez, Andrea Natalí Zárate Villacrés, Marcelo David Guerra Valladares, Mayte Lisbeth Mieles Mariño, Jefferson Javier Castillo Cevallos","doi":"10.12688/f1000research.147701.2","DOIUrl":"https://doi.org/10.12688/f1000research.147701.2","url":null,"abstract":"<p><strong>Background: </strong>Geopolymers are alternative materials to cement because they require less energy in their production process; hence, they contribute to the reduction in CO ₂ emissions. This study aims to evaluate the possibility of using industrial residues such as silica fume (SF) to improve the physical and mechanical properties of a pumice stone (PS)-based geopolymer.</p><p><strong>Methods: </strong>Through an experimental methodology, the process starts with the extraction, grinding, and sieving of the raw material to carry out the physical and chemical characterization of the resulting material, followed by the dosage of the geopolymer mixture considering the factors that influence the resistance mechanical strength. Finally, the physical and mechanical properties of the geopolymer were characterized. This research was carried out in four stages: characterization of the pumice stone, design of the geopolymer through laboratory tests, application according to the dosage of the concrete, and analysis of the data through a multi-criteria analysis.</p><p><strong>Results: </strong>It was determined that the optimal percentage of SF replacement is 10%, which to improves the properties of the geopolymer allowing to reach a maximum resistance to compression and flexion of 14.10 MPa and 4.78 MPa respectively, showing that there is a direct relationship between the percentage of SF and the resistance.</p><p><strong>Conclusions: </strong>Geopolymer preparation involves the use of PS powder with a composition rich in silicon and aluminum. The factors influencing strength include the ratio of sodium silicate to sodium hydroxide, water content, temperature, curing time, molarity of sodium hydroxide, and binder ratio. The results showed an increase in the compression and flexural strength with 10% SF replacement. The geopolymer's maximum compressive strength indicates its non-structural use, but it can be improved by reducing the PS powder size.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11362735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of efficacy of <i>Trayodashang Guggul</i> versus <i>Rasona Pinda</i> as an adjuvant with <i>Katibasti</i> in the management of <i>Grudhrasi</i> (Sciatica):  A randomized controlled trial.","authors":"Mayank Rai, Sadhana Misar, Reeya Gamne","doi":"10.12688/f1000research.139568.3","DOIUrl":"10.12688/f1000research.139568.3","url":null,"abstract":"<p><strong>Background: </strong>In ayurveda, sciatica can be correlated to ' <i>Grudhrasi'</i> under <i>Vata Nanatmaja-Vyadhi</i> (neurological disorders caused by <i>Vata</i>, one of the bodily humour). In this mainly bodily humours <i>vata</i> and <i>kapha</i> are vitiating producing symptoms like piercing pain, stiffness, twitching, numbness and pain radiating from lumbosacral region to lower limb up to the foot. Therapeutic plan includes stabilizing and bringing back the vitiated vata and kapha humours to equilibrium. The prevalence of sciatica varies considerably ranging from 3.8% in the working population to 7.9% in the nonworking population.</p><p><strong>Aim: </strong>Comparative evaluation of efficacy of <i>Rasonapinda</i> and <i>Trayodashang guggul</i> as an adjuvant to <i>katibasti</i> (oil pooling therapy) in the management of <i>Grudhrasi</i> (Sciatica).</p><p><strong>Objectives: </strong>To assess the efficacy of <i>Rasonapinda</i> as an adjuvant to <i>katibasti</i> in subjective and objective parameters of <i>Grudhrasi</i> (Sciatica). To assess the efficacy of <i>Trayodashang guggul</i> as an adjuvant to <i>katibasti</i> in subjective and objective parameters of <i>Grudhrasi</i> (Sciatica). To compare the efficacy of <i>Rasonapinda</i> and <i>Trayodashang guggul</i> as an adjuvant to <i>katibasti</i> in subjective and objective parameters. Standardisation of <i>Rasonapinda</i> (modified formvati).</p><p><strong>Methods: </strong>In this study, a total of 60 patients will be enrolled and divided equally into two groups. In group A, <i>Trayodashang Guggul</i> 500 mg twice a day after meal with warm water for 30 days adjuvant with katibasti for the initial 7 days will be given. In group B, <i>Rasonapinda</i> 500 mg twice a day after meal with warm water adjuvant with katibasti for the initial 7 days will be given for 30 days.</p><p><strong>Result: </strong>The result will be assessed on baseline of subjective and objective parameters and data will be compared after treatment.</p><p><strong>Conclusions: </strong>It will be based on observations and results obtained.</p><p><strong>Trial registration: </strong>CTRI No. - CTRI/2022/12/048534 Dated - 27/12/2022.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors contributing to online child sexual abuse in Bangladesh: A qualitative inquiry.","authors":"Md Redwanul Islam, Muhammad Ibrahim Ibne Towhid, Merium Salwa, Anika Tasnim, Wai Wai Mroy, Md Maruf Haque Khan, Md Atiqul Haque","doi":"10.12688/f1000research.141568.2","DOIUrl":"10.12688/f1000research.141568.2","url":null,"abstract":"<p><strong>Background: </strong>Children globally, including in Bangladesh, are facing various forms of online sexual abuse including sextortion, exploitation, body shaming, and blackmail. They are also coerced into engaging in intimate activities, harassed through the sending of sexual content, among other forms of abuse. We aimed to explore the root cause of online child sexual abuse (OCSA) in Bangladesh.</p><p><strong>Methods: </strong>This qualitative research design utilized in-depth interviews (IDIs) and key informant interviews (KIIs) between February and April 2022. The study sample comprised 21 school-going children aged 13-17 years, selected from two different geographical settings (10 from rural areas and 11 from urban areas) in Bangladesh using purposive sampling techniques. They participated in in-depth interviews (IDIs) while additional data was obtained through key informant interviews (KIIs) with 11 multidisciplinary stakeholders.</p><p><strong>Results: </strong>Children from both rural and urban areas reported facing abuse in various ways, such as being asked to send naked photos, being invited to be naked in video calls, and being invited to have virtual sex, among others, over the internet.</p><p><strong>Conclusions: </strong>The government should consider integrating OCSA education into secondary levels. Additionally, there should be efforts to ensure a safe online environment through content scrutiny, promotion of outdoor activities, and community campaigns. An anonymous reporting system must be implemented, and strict measures under the Children's Act must be enforced against perpetrators. Further intervention studies are needed to ensure effective child protection measures in Bangladesh.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11143399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141199434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tourette syndrome research highlights from 2023.","authors":"Andreas Hartmann, Per Andrén, Cyril Atkinson-Clement, Virginie Czernecki, Cécile Delorme, Nanette Mol Debes, Simon Morand-Beaulieu, Kirsten Müller-Vahl, Peristera Paschou, Natalia Szejko, Apostolia Topaloudi, Kevin J Black","doi":"10.12688/f1000research.150931.2","DOIUrl":"https://doi.org/10.12688/f1000research.150931.2","url":null,"abstract":"<p><p>In this, the tenth annual update for the F1000Research Tics collection, we summarize research reports from 2023 on Gilles de la Tourette syndrome and other tic disorders. The authors welcome article suggestions and thoughtful feedback from readers.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11409664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparison of Pain Before and After Transfusion in Adult transfusion-dependent thalassemia (TDT) Using BPI-SF.","authors":"Uni Gamayani, Shenny Dianathasari Santoso, Asep Nugraha Hermawan, Pandji Irani Fianza, Ramdan Panigoro","doi":"10.12688/f1000research.75952.2","DOIUrl":"10.12688/f1000research.75952.2","url":null,"abstract":"<p><p>Background <i>Pain</i> is a complication in patients with transfusion-dependent thalassemia (TDT). There are several mechanisms underlying pain in people with thalassemia and low hemoglobin at the end of the transfusion cycle was the most etiology. Pain can develop into chronic pain and interfere with the quality of life. The Brief Pain Inventory Short Form (BPI-SF) can help identify pain in people with TDT. The present study aimed to compare pain before and after transfusion in adult TDT patients. Methods It was an analytical observational study using a cross-sectional design on adult TDT patients with pain who came to the Haemato-Oncology Clinic of Dr. Hasan Sadikin Hospital Bandung. This study was conducted from December 2020 to July 2021. All subjects were assisted in filling out the Indonesian version of the BPI-SF questionnaire hemoglobin levels were examined and before and after transfusion, then paired test analysis was performed using the Wilcoxon Test. Results This study is conducted on 60 adult TDT patients with symptoms of pain. The median value of pain intensity and pain interferes with life obtained from the Indonesian version of the BPI-SF score after transfusion decreased significantly compared to before transfusion (NRS 5 vs. 0 and 2.8 vs. 0; p=0.0001). Conclusion There is a significant difference in pain intensity and pain interfere with life in adults with TDT before and after transfusion. It is necessary to carry out pain assessments for thalassemia patients.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11421607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142336360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A study of association between early menarche and anxiety in undergraduate  students.","authors":"Poorva Bakshi, Sharanya B Shetty, Abira Sharma, Vasudha K G, Keshava Pai, Radhika K, Priyanka Renita D'Souza, Reshma N S","doi":"10.12688/f1000research.149757.2","DOIUrl":"10.12688/f1000research.149757.2","url":null,"abstract":"<p><strong>Background: </strong>Anxiety has been reported to be one of the most common epidemics in recent years. The present study focused on understanding the association between early menarche and the prevalence of anxiety and anxiety symptoms among adult undergraduate students.</p><p><strong>Methods: </strong>This was an observational, case-control study. The sample included 146 young female adults aged more than or equal to 18 years pursuing the Bachelor of Medicine and Bachelor of Surgery (MBBS) and Bachelor of Dental Sciences (BDS). Using an online questionnaire, participants were asked to recall and enter the age at which they attained menarche. We used the Generalized Anxiety Disorder 7- Item Questionnaire (GAD-7) to measure the severity of their present anxiety symptoms.</p><p><strong>Results: </strong>The results showed a significant increase in anxiety symptoms in participants who had early menarche compared to those who did not have early menarche. The mean score on the GAD-7 Questionnaire for the cases was 9.93 and the control group was 6.89. The GAD-7 scores among the cases group were significantly higher in the GAD-7 scores than in the control group.</p><p><strong>Conclusions: </strong>This study concluded that early menarche is associated with higher anxiety levels in young adults.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11336558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142016872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}