F1000Research最新文献

{"title":"Eye-gesture control of computer systems via artificial intelligence.","authors":"Nachaat Mohamed","doi":"10.12688/f1000research.144962.3","DOIUrl":"10.12688/f1000research.144962.3","url":null,"abstract":"<p><strong>Background: </strong>Artificial Intelligence (AI) offers transformative potential for human-computer interaction, particularly through eye-gesture recognition, enabling intuitive control for users and accessibility for individuals with physical impairments.</p><p><strong>Methods: </strong>We developed an AI-driven eye-gesture recognition system using tools like OpenCV, MediaPipe, and PyAutoGUI to translate eye movements into commands. The system was trained on a dataset of 20,000 gestures from 100 diverse volunteers, representing various demographics, and tested under different conditions, including varying lighting and eyewear.</p><p><strong>Results: </strong>The system achieved 99.63% accuracy in recognizing gestures, with slight reductions to 98.9% under reflective glasses. These results demonstrate its robustness and adaptability across scenarios, confirming its generalizability.</p><p><strong>Conclusions: </strong>This system advances AI-driven interaction by enhancing accessibility and unlocking applications in critical fields like military and rescue operations. Future work will validate the system using publicly available datasets to further strengthen its impact and usability.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"109"},"PeriodicalIF":0.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11876798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A long tail of truth and beauty: A zigzag pattern of feather formation determines the symmetry, complexity, and beauty of the peacock's tail.","authors":"Rama Singh, Santosh Jagadeeshan","doi":"10.12688/f1000research.149948.2","DOIUrl":"https://doi.org/10.12688/f1000research.149948.2","url":null,"abstract":"<p><strong>Background: </strong>Darwin assumed that the peacock's long train was maladaptive and was the indirect effect of selection by female mate choice based on the train's beauty. While a relationship between the feathers' elaborate features and mating success has been shown in some studies, what features of the train females are attracted to remains controversial.</p><p><strong>Methods: </strong>We used museum specimens to examine the anatomical plan underlying feather development responsible for the train's symmetry. We developed a model based on an alternate arrangement of primordial feather buds during development and locations of concentric circles of eyespot distribution using the pattern on the train as a template.</p><p><strong>Results: </strong>We observed a zigzag pattern of feather follicles that determined both the number and the arrangement of eyespots on the train. Our model explains the bilateral symmetry of train feathers, the hexagonal arrangement of eyespots on the train, and the concentric color rings of the eyespots. While the zigzag pattern explains the symmetry, complexity, and (structural) beauty of the peacock's train, it also precludes variation in eyespot number except by annual addition of new feathers as a function of age.</p><p><strong>Conclusions: </strong>We propose a multimodal model of mate choice which holds that (1) eyespot number and feather length are developmentally correlated and females see them not as separate traits but as one complex trait combining both, (2) females may not always choose males with the largest number of eyespots, as old males may lack vigor, and (3) females may choose mates on the basis of train size, vigor, and beauty. The maladaptation of the long tail is a byproduct of the adaptation of the tall train. Who would have thought that zigzag arrangement, the densest form of spherical packing, when applied to the living world would produce such profound effects on phenotypic diversity.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"520"},"PeriodicalIF":0.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A streamlined workflow for long-read DNA methylation analysis with NanoMethViz and Bioconductor.","authors":"Shian Su, Lucinda Xiao, James Lancaster, Tamara Cameron, Kelsey Breslin, Peter F Hickey, Marnie E Blewitt, Quentin Gouil, Matthew E Ritchie","doi":"10.12688/f1000research.155204.2","DOIUrl":"10.12688/f1000research.155204.2","url":null,"abstract":"<p><p>Long-read sequencing technologies have transformed the field of epigenetics by enabling direct, single-base resolution detection of DNA modifications, such as methylation. This produces novel opportunities for studying the role of DNA methylation in gene regulation, imprinting, and disease. However, the unique characteristics of long-read data, including the modBAM format and extended read lengths, necessitate the development of specialised software tools for effective analysis. The NanoMethViz package provides a suite of tools for loading in long-read methylation data, visualising data at various data resolutions. It can convert the data for use with other Bioconductor software such as bsseq, DSS, dmrseq and edgeR to discover differentially methylated regions (DMRs). In this workflow article, we demonstrate the process of converting modBAM files into formats suitable for comprehensive downstream analysis. We leverage NanoMethViz to conduct an exploratory analysis, visually summarizing differences between samples, examining aggregate methylation profiles across gene and CpG islands, and investigating methylation patterns within specific regions at the single-read level. Additionally, we illustrate the use of dmrseq for identifying DMRs and show how to integrate these findings into gene-level visualization plots. Our analysis is applied to a triplicate dataset of haplotyped long-read methylation data from mouse neural stem cells, allowing us to visualize and compare the characteristics of the parental alleles on chromosome 7. By applying DMR analysis, we recover DMRs associated with known imprinted genes and visualise the methylation patterns of these genes summarised at single-read resolution. Through DMR analysis, we identify DMRs associated with known imprinted genes and visualize their methylation patterns at single-read resolution. This streamlined workflow is adaptable to common experimental designs and offers flexibility in the choice of upstream data sources and downstream statistical analysis tools.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1243"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"All-cause mortality according to COVID-19 vaccination status: An analysis of the UK office for National statistics public data.","authors":"Marco Alessandria, Giovanni Malatesta, Giovanni Di Palmo, Marco Cosentino, Alberto Donzelli","doi":"10.12688/f1000research.154058.2","DOIUrl":"10.12688/f1000research.154058.2","url":null,"abstract":"<p><strong>Background: </strong>The mass vaccination campaign against COVID-19 has been commonly considered the best response to the global COVID-19 pandemic crisis. However, assessment of its real-world effect can be performed by analysis of all-cause mortality by vaccination status. The UK is perhaps the only country which has made publicly available all-cause mortality data by vaccination status.</p><p><strong>Methods: </strong>Data from April 2021 to May 2023 published by the UK Office for National Statistics (ONS) were retrospectively analyzed by age groups and vaccination status; the standardized mortality ratio (SMR) for all-cause and non-COVID-19 mortality was calculated against the corresponding unvaccinated groups.</p><p><strong>Results: </strong>We found that across all age groups, all-cause mortality SMRs increased from a certain date, dependent on the age group. Across all age groups, all-cause mortality SMRs were initially much lower than 1. However, due to their increase, by a certain date for the 18-39, 80-89 and 90+ age groups they exceeded the reference value. For the other age groups, the date at which the SMR would reach 1 can be predicted, provided the trend is maintained. Non-COVID-19 SMRs' trends were very similar. Their initial values much lower than 1 are suggestive of significant biases in the ONS dataset, leading to underestimate the risks for the vaccinated people, as it is implausible that COVID-19 vaccines protect against non-COVID-19 deaths.</p><p><strong>Conclusions: </strong>The increase over time in all-cause death SMRs in vaccinated people compared to unvaccinated, and their excess from the reference values for certain age groups, should be carefully considered to understand the underlying factors. Furthermore, since the initial values of the SMRs are much lower than 1, we assume the presence of significant biases in the ONS dataset, leading to understimate the risks for the vaccinated people, as it is implausible that COVID-19 vaccines protect against non-COVID-19 deaths. It would be desirable for other major countries to systematically collect all-cause mortality by vaccination status and, in the meantime, a pending indepth investigations, much greater caution should be exercised in promoting mass vaccination campaigns.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"886"},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Community preparedness for earthquake disasters: A preliminary assessment of awareness and disaster infrastructure response in Cianjur, West Java-Indonesia.","authors":"Dewayany Sutrisno, Yatin Suwarno, Ati Rahadiati, Muhammad Iqbal Habibie, Prabu Kresna Putra, Hari Prayogi, Amien Widodo, Fathia Zulfati Sabrina, Ahmad Kosasih","doi":"10.12688/f1000research.143577.3","DOIUrl":"10.12688/f1000research.143577.3","url":null,"abstract":"<p><strong>Background: </strong>The danger of earthquakes poses a serious threat to people worldwide. One of the most significant challenges is preparing communities to cope effectively with this disaster. Therefore, understanding earthquake hazards is critically important for preparedness, mitigation, and an effective response to this threat. This report aims to observe and conduct a preliminary assessment of the degree to which community preparedness for earthquake disasters has been implemented.</p><p><strong>Methods: </strong>Empirical data were obtained from survey respondents and interviews. The respondents were members of a community affected by the Cianjur earthquake, which occurred on November 21, 2022. The data were analysed using the mean range approach, based on Likert scales. Additionally, the Spearman correlation method was employed to indicate the relationship between community awareness and infrastructure readiness.</p><p><strong>Result: </strong>Based on empirical evidence and preliminary analysis, it is evident that the preparedness of the community to respond effectively to earthquake catastrophes is inadequate. An apparent lack of readiness is observed in the inadequate construction of housing that fails to meet disaster standards, and the absence of disaster response facilities is notable.</p><p><strong>Conclusions: </strong>Based on our initial assumption, it appears that knowledge related to disaster resilience in this area has not been adequately disseminated or socialized. However, this premise requires further investigation.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"256"},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: <i>Hymenolepis diminuta</i> in an asymptomatic Ecuadorian child.","authors":"Zulbey Rivero de Rodriguez, Ader Ponce, Anthony Vera, Angela Bracho, Anita Murillo","doi":"10.12688/f1000research.155856.2","DOIUrl":"10.12688/f1000research.155856.2","url":null,"abstract":"<p><strong>Background: </strong>The cestode <i>Hymenolepis diminuta</i> is a cosmopolitan parasite, which in the adult stage is usually found in the small intestine of rats and accidentally in humans.</p><p><strong>Case report: </strong>We describe the finding of eggs of this parasite in an asymptomatic 3-year-old child. The child had extremely high IgE values of 1,376 IU/ml. After receiving treatment with Albendazole suspension 400mg/20mL, on the 10th day post-treatment, he showed no <i>H. diminuta</i> eggs in his fecal matter.</p><p><strong>Conclusions: </strong>Detailed morphological review of <i>Hymenolepis nana</i>-like eggs is recommended to distinguish them from <i>H. diminuta</i> eggs.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1119"},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11822246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Through restful waters and deep commotion: A study on burnout and health impairment of Italian seafarers from the JD-R model perspective.","authors":"Francesco Buscema, Lorenzo Cena, Clarissa Cricenti, Margherita Zito, Lara Bertola, Lara Colombo","doi":"10.12688/f1000research.159198.1","DOIUrl":"10.12688/f1000research.159198.1","url":null,"abstract":"<p><strong>Background: </strong>The work experience of seafarers differs significantly from other land-based occupations due to several factors, particularly remoteness and the restricted work environment. This study seeks to examine the impact of burnout and health impairment in the maritime industry, using the Job Demand-Resources theory as a framework.</p><p><strong>Methods: </strong>To investigate these phenomena, an online questionnaire was sent to 629 Italian seafarers and we conducted analysis on a valid sample of 239 respondents (94.6% men, Mage = 39.44, SD = 12.8). We tested a mediated Structural Equation Model (SEM) aimed at predicting negative health outcomes.</p><p><strong>Results: </strong>The results show that burnout plays a mediating role between job demands (such as workload and cognitive strain) and health impairment (such as sleep quality and physical well-being) (Total Indirect Effect = 0.443, <i>p</i> < .0001) as well as between job resources (such as social support and transformational leadership) and health impairment (Total Indirect Effect = -0.249, <i>p</i> < .0001). Furthermore, the findings highlight the direct influence of occupational resources on seafarers' health.</p><p><strong>Conclusions: </strong>The discussion highlights the urgent need for more research in the field of organisational psychology in the maritime industry and the discrepancies between these findings, which are consistent with the existing maritime literature, and other studies that do not include seafarers in their sample groups.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"19"},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11751612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnitude and Factors Associated with Research Misconduct at a Public University in Ethiopia: A Cross-Sectional Survey.","authors":"Habtamu Belay Hailu, Telahun Teka Wolde, Betselot Yirsaw Wubete, Joseph Ali, Sintayehu Tsegaye Bitew","doi":"10.12688/f1000research.159997.2","DOIUrl":"10.12688/f1000research.159997.2","url":null,"abstract":"<p><strong>Background: </strong>Research integrity, essential for ethical scientific research, has been inadequately addressed in Ethiopia, resulting in gaps in addressing misconduct like plagiarism, falsification and fabrication. The aim of this study was to assess the magnitude and factors associated with research misconduct at a public university in Ethiopia.</p><p><strong>Methods: </strong>An institutional-based cross-sectional study was conducted on a random sample of researchers. Data were collected via a self-administered, structured questionnaire, which was adapted from a similar study. The collected data were analysed using descriptive, bivariate, and multivariable logistic regression.</p><p><strong>Result: </strong>A total of 244 researchers participated in the study, resulting in an 82% response rate. In our study, 37.7% of participants reported engaging in at least one form of misconduct, 95% CI [31.6%, 44.1%]. Authorship misconduct was the most common form of self-reported misconduct (47.5%), 95% CI [41.1%, 54.0%], followed by fabrication and falsification (40.6%), 95% CI [34.4%, 47.0%]. Publication pressure was significantly associated with research misconduct (AOR = 3.18; 95% CI: [1.02, 9.95]).</p><p><strong>Conclusion: </strong>This study highlights the prevalence of research misconduct and questionable research practices among academic researchers, with authorship misconduct, fabrication, falsification, and plagiarism being the most commonly reported types. Attitudes toward research misconduct and self-reported involvement were influenced by academic position, research experience, and publication pressure, with junior researchers being more likely to report engaging in misbehavior. While ethics training has occasionally been associated with reduced rates of research misconduct, its effectiveness remains uncertain, as institutional culture, supervision, and mentorship may play a more significant role. Addressing research misconduct requires a comprehensive approach that extends beyond ethical instruction, incorporating targeted support for early-career researchers, open dialogue, and institutional policy reforms.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"111"},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Value of Applying Big Data Analytics in Health Supply Chain Management.","authors":"Dina Al Nuaimi, Niyi Awofeso","doi":"10.12688/f1000research.156525.4","DOIUrl":"10.12688/f1000research.156525.4","url":null,"abstract":"<p><p>This study aims to evaluate the impact of big data analytics (BDA) on the performance of healthcare supply chain management (HCSCMP) by examining both overall efficiency improvements and identifying critical success factors for effective implementation. Through a systematic literature review, the research investigates how BDA enhances real-time decision-making within healthcare supply chains (HCSCs) and identifies the key enablers required for successful BDA adoption. A comprehensive search strategy was employed to analyze 65 papers, resulting in the inclusion of 39 studies published between 2016 and 2023. The review revealed a preference for literature reviews and questionnaires as the primary research methods. The findings indicate that BDA significantly improves HCSCs' efficiency, particularly in real-time decision-making and operational management. However, successful BDA implementation depends on addressing critical enablers and overcoming associated challenges.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1237"},"PeriodicalIF":0.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11842960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Emergency endovascular management of a ruptured giant abdominal aortic aneurysm with severely angulated and conical shaped neck using novel multiple stiff wire technique.","authors":"Taofan Taofan, Iwan Dakota, Suko Adiarto, Suci Indriani, Ruth Grace Aurora, Rendra Mahardhika Putra, Bagas Adhimurda Marsudi, Jonathan Edbert Afandy, Melani Limenco Benly, Kanya Paramastri, Macmilliac Lam, Muhammad Rafli Iqbal, Keviano Bobby Saputro, Sung Gwon Kang, Bambang Widyantoro","doi":"10.12688/f1000research.152300.2","DOIUrl":"https://doi.org/10.12688/f1000research.152300.2","url":null,"abstract":"<p><strong>Background: </strong>Ruptured abdominal aortic aneurysm (rAAA) is commonly fatal, with an overall mortality rate of nearly 90%, and the risk of subsequent rupture remains high, especially in large aneurysm diameters or progressive disease. Unfavorable neck anatomy in EVAR is linked to early graft failure and long-term complications. Recently, a novel multiple stiff wire (MSW) technique has been developed to overcome the challenges of hostile neck anatomy without introducing additional devices and procedural complexity. It has also been feasible in a series of elective cases. In this case, we report the first-ever utilization of the MSW technique in an emergency case of an acute contained rAAA with a conical-shaped, severely angulated neck who underwent Endovascular Aortic Repair (EVAR).</p><p><strong>Case presentation: </strong>A 61-year-old man came with intermittent sharp stomach pain radiating to his back since three weeks ago. Physical examination showed elevated blood pressure and anemic conjunctiva. Laboratory examinations showed anemia, leukocytosis, elevated D-dimer level, high creatinine level, and low eGFR. CT-Scan Angiography (CTA) revealed severely hostile anatomy, a conical-shaped abdominal aorta aneurysm with a length of 13.2 cm and a maximum diameter of 9.3 cm with angulation of 90.1°. The patient was diagnosed with Ruptured AAA with a conical-shaped, severely angulated neck. Endovascular Aortic Repair (EVAR) management with MSW technique was planned for him. After four days, The patient was discharged in a clinically stable condition with optimal medical treatment and education.</p><p><strong>Conclusion: </strong>The endovascular approach could be performed in emergency settings and has been proven to reduce length of stay, mortality, and morbidity rates. In this case, the endovascular approach with the MSW technique showed promising results for the patient.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1074"},"PeriodicalIF":0.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12000802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}