F1000Research最新文献

{"title":"Hybrid optimization technique for matrix chain multiplication using Strassen's algorithm.","authors":"Srinivasarao Thota, Thulasi Bikku, Rakshitha T","doi":"10.12688/f1000research.162848.1","DOIUrl":"10.12688/f1000research.162848.1","url":null,"abstract":"<p><strong>Background: </strong>Matrix Chain Multiplication (MCM) is a fundamental problem in computational mathematics and computer science, often encountered in scientific computing, graphics, and machine learning. Traditional MCM optimization techniques use Dynamic Programming (DP) with Memoization to determine the optimal parenthesization for minimizing the number of scalar multiplications. However, standard matrix multiplication still operates in O(n ³) time complexity, leading to inefficiencies for large matrices.</p><p><strong>Methods: </strong>In this paper, we propose a hybrid optimization technique that integrates Strassen's algorithm into MCM to further accelerate matrix multiplication. Our approach consists of two key phases: (i) matrix chain order optimization, using a top-down memoized DP approach, we compute the best multiplication sequence, and (ii) hybrid multiplication strategy, we selectively apply Strassen's algorithm for large matrices (n ≥ 128), reducing the complexity from O(n ³) to O(n ^2.81), while using standard multiplication for smaller matrices to avoid recursive overhead. We evaluate the performance of our hybrid method through computational experiments comparing execution time, memory usage, and numerical accuracy against traditional MCM and Strassen's standalone multiplication.</p><p><strong>Results: </strong>Our results demonstrate that the proposed hybrid method achieves significant speedup (4x-8x improvement) and reduces memory consumption, making it well-suited for large-scale applications. This research opens pathways for further optimizations in parallel computing and GPU-accelerated matrix operations.</p><p><strong>Conclusion: </strong>This study presents a hybrid approach to Matrix Chain Multiplication by integrating Strassen's algorithm, reducing execution time and memory usage. By selectively applying Strassen's method for large matrices, the proposed technique improves efficiency while preserving accuracy. Future work can focus on parallel computing and GPU acceleration for further optimization.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"341"},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12000801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In vitro</i> antitumor capacity of extracts obtained from the plants <i>Plukenetia volubilis</i> (Sacha inchi) and <i>Moringa oleifera</i> in gastric cancer.","authors":"Jose Vargas, Natalia Arbelaez, Denny Cardenas, Javier Murillo, Victoria Ospina, Sara Robledo, Javier Soto","doi":"10.12688/f1000research.158563.2","DOIUrl":"https://doi.org/10.12688/f1000research.158563.2","url":null,"abstract":"<p><strong>Background: </strong>Gastric cancer is the fifth most common cancer and the third leading cause of cancer deaths worldwide. Perioperative or adjuvant chemotherapy improves survival in patients with stage 1B or higher cancers. <i>Moringa oleifera</i> and <i>Plukenetia volubilis</i> (Sacha inchi) have been reported to enhance various biological functions, including antitumor and antiproliferative activity.</p><p><strong>Methods: </strong>In order to evaluate this potential present in crude extracts of the leaves of these plants, as well as the seed oil of <i>P.volubilis</i>, the antitumor activity was determined according to the effect of these derivatives on different biological parameters such as cytotoxicity, proliferation, cell cycle, apoptosis (among others), in AGS cells (CRL-1739).</p><p><strong>Results: </strong>All extracts tested were cytotoxic at 90 and 160 μg/ml concentrations <i>. P. volubilis</i> seed oil showed 95% mortality at 1% concentration (CC ₅₀ = 46.7%). Cell proliferation was inhibited, and all extracts affected the cell cycle, but the <i>P. volubilis</i> oil significantly induced an accumulation of AGS cells in the sub G1 phase, inducing DNA fragmentation as a mechanism of cell death. The ethanolic <i>M. oleifera</i> leaf extract also inhibited cell migration.</p><p><strong>Conclusion: </strong><i>M. oleifera</i>, <i>P. volubilis</i> leaf extracts and <i>P. volubilis</i> seed oil can potentially be antitumor products. Further validation in a murine model of gastric cancer is needed to investigate the antitumor potential of these extracts further and to continue the development of herbal products that can help in the management of this type of tumor.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"194"},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of Surface Damage on Miniplates: A Study of Bacterial Attachment Across Various Strains.","authors":"Bramasto Purbo Sejati, Tetiana Haniastuti, Ahmad Kusumaatmaja, Maria Goreti Widyastuti","doi":"10.12688/f1000research.159954.1","DOIUrl":"10.12688/f1000research.159954.1","url":null,"abstract":"<p><strong>Background: </strong>Postoperative infection and rejection of miniplates in maxillofacial surgery are linked to surface irregularities and bacterial adhesion. This study investigated the physical and microbiological characteristics of patient-rejected miniplates to elucidate factors contributing to implant failure.</p><p><strong>Methods: </strong>Forty miniplates, including straight-type BSSO and L-shaped designs, were collected from patients. Macro photography documented surface deformities. Contact angle measurements assessed surface wettability. Bacterial adhesion for Staphylococcus aureus, Streptococcus mutans, Pseudomonas aeruginosa, and Enterococcus faecalis was quantified via the crystal violet assay. Scanning electron microscopy (SEM) was used to visualize microbial colonization.</p><p><strong>Results: </strong>Macro images showed visible deformations, especially in the bridge areas of straight-type BSSO plates. Contact angle analysis revealed significantly greater hydrophobicity in rejected plates than controls (mean: 89.6° vs. 72.3°, p < 0.01). Rejected plates demonstrated significantly increased adhesion of S. aureus and S. mutans (p < 0.001), particularly on mandibular plates. P. aeruginosa adhered more to control plates (p < 0.05), while E. faecalis showed no significant difference between groups. SEM confirmed dense bacterial clusters, with S. aureus forming cocci aggregates and S. mutans forming chains, particularly in regions of surface distortion.</p><p><strong>Conclusion: </strong>Rejected miniplates exhibit increased surface roughness and hydrophobicity, correlating with elevated bacterial adhesion. These findings highlight the need for improved surface design or coating technologies to reduce biofilm formation and enhance clinical outcomes in maxillofacial surgery.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"158"},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral congenital muscular torticollis in infants, report of two cases.","authors":"Anna Öhman","doi":"10.12688/f1000research.143499.3","DOIUrl":"https://doi.org/10.12688/f1000research.143499.3","url":null,"abstract":"<p><strong>Background: </strong>Congenital muscular torticollis (CMT) is a well-known diagnosis among physiotherapists specializing in pediatric care, especially when working with infants. However, knowledge of bilateral torticollis is limited. The purpose of this article was to describe how bilateral torticollis may present itself clinically.</p><p><strong>Case: </strong>Case I describes an infant with CMT with a sternocleidomastoid tumor (SMT) on the right side, with some limitation in rotation towards the right side and in lateral flexion towards the left side, the muscle on the right side was shortened. While sitting with support, he tilted his head to the left and was stronger in the lateral flexors on the left side which fits well with postural left-sided torticollis. The other infant had bilateral muscular torticollis, the sternocleidomastoid muscle had thickened bilaterally, and both active and passive rotations were affected. The head was held in flexion, and active rotation was severely limited on both sides. For both cases the therapeutic interventions were to gain a normal range of motion (ROM) and a good head position.</p><p><strong>Conclusions: </strong>CMT can appear in different ways and may be bilateral. Both infants gained good ROM and better head position, however case I still needs some training. To gain more knowledge about bilateral CMT, we should follow these cases over a longer period of time. It is important to communicate and discuss our experiences with each other to understand rare cases of CMT.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"211"},"PeriodicalIF":0.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological And Morphometric analysis of Human External Ear with Its Implications in Sex and Stature Estimation -- A Preliminary Observational Study.","authors":"Shwetha Acharya, Chandni Gupta, Vikram Palimar, Sneha Guruprasad Kalthur, Purnima Adhikari","doi":"10.12688/f1000research.160629.2","DOIUrl":"10.12688/f1000research.160629.2","url":null,"abstract":"<p><strong>Background: </strong>The human ear is unique to individuals, and ear prints, like fingerprints, are discrete enough to distinguish identical twins. Thus, this study aimed to estimate the stature and sex using various morphometric parameters and morphological features of the external ear for forensic identification.</p><p><strong>Methods: </strong>This was a cross-sectional observational study involving 40 participants recruited using simple random sampling technique. Eighteen measurements were taken, and various morphological features were noted for both the right and left ears. A digital Vernier caliper was used to measure all linear parameters. The angles were measured using a goniometer. Normal distribution was verified using the Shapiro-Wilk test. For normally distributed parameters, an independent t-test was used, and for non-normally distributed parameters, the Mann-Whitney U test was used to compare sexes. To compare the right and left parameters, independent t-tests (for normally distributed data) and Mann-Whitney U tests (for non-normally distributed data) were applied. Sex determination and stature estimation were performed using logistic regression analysis.</p><p><strong>Results: </strong>In males and females, the most common shape was oval (47.5%), and the ear lobe was free (45%). When comparing the parameters of males on the right and left sides, it was noticed that only the ear inclination angle and concha mastoid angle showed significant differences (p < 0.05). It was seen that the right lobe width showed perfect separation, indicating its potential as an extremely reliable predictor of sex. It was noted that in females, the strongest correlation with height was with the ear inclination angle on both sides.</p><p><strong>Conclusion: </strong>We can conclude from the results of this study that the right lobe width of external ear can be a reliable predictor of sex. Ear inclination angle on both sides showed strongest correlation with height. The results of this study can help forensic anthropologists identify the sex and stature of a person from various ear measurements in young South Indian adults.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"119"},"PeriodicalIF":0.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12032520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An integrated data pipeline for semantic data representation of the flame spray pyrolysis process.","authors":"Manuel Vollbrecht, Keno Krieger, Jannis Grundmann, Henk Birkholz, Norbert Riefler, Lutz Mädler","doi":"10.12688/f1000research.161252.2","DOIUrl":"https://doi.org/10.12688/f1000research.161252.2","url":null,"abstract":"<p><p>Ongoing digitalization and data-driven developments in materials science and engineering (MSE) emphasize the growing importance of reusing research data and enabling machine accessibility, which requires robust data management and consistent semantic data representation. Ontologies have emerged as powerful tools for establishing interoperable and reusable data structures from inconsistent data structures. Despite advancements in semantic data representation for specific applications, integrating application ontologies with primary data repositories, such as electronic lab notebooks (ELNs), to feed world data remains an open task. As a use case in the MSE domain, this work presents a system based on semantic technologies from the point of view of engineers, developed with the help of information scientists, and unraveled on a small scale. The development of an application ontology (AO) was elaborated for flame spray pyrolysis (FSP) processes with the implementation of a data pipeline. The proposed FSP application ontology emerges from experimental in-house best-practice procedures and is adapted to the mid-level Project Material Digital core ontology (PMDco) to allow interoperability within the MSE domain. The pipeline retrieves manually acquired experimental data from an ELN, translates it into a machine-actionable format, and converts it into a Resource Description Framework (RDF) format to support semantic interoperability. The latter was stored in a triple store with a SPARQL interface, enabling findable and accessible datasets that are searchable and traceable. By creating semantically linked data structures in line with FAIR principles, this approach allows traceable and findable experimental results between stakeholders through both human-readable and machine-actionable formats. Seamless integration of the modular microservices of the data pipeline within established lab practices minimizes disruption while maintaining the software framework. The present work demonstrates the practical implementation of a FAIR data pipeline within a laboratory setting, paving the way for future data-centric science.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"173"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A phenomenological analysis of the emotional experiences of graduate preservice student teachers in Indonesia.","authors":"Sunardi Sunardi, Famala Eka Sanhadi Rahayu, Desy Rusmawaty, Istanti Hermagustiana, Dyah Sunggingwati","doi":"10.12688/f1000research.132112.3","DOIUrl":"10.12688/f1000research.132112.3","url":null,"abstract":"<p><strong>Background: </strong>Addressing preservice teachers' emotions can help them develop the emotional connections necessary for successful teaching practicums and professional learning experiences. To understand preservice teachers' emotions towards their surroundings, the researchers used an emotional geography framework to map out the source of their negative and positive emotions and how those feelings affect their beliefs, teaching style, and paradigms. Emotional geographies were divided into two categories (i.e., emotional distance and emotional closeness), which were further mapped into five major themes (i.e., sociocultural, moral, professional, physical, and political). This study aims to investigate the emotional geographies of graduate preservice teachers during their teaching practicums in Indonesia by adapting Hargreaves' (2001) theoretical model, thereby identifying key dimensions and validating the adapted framework.</p><p><strong>Methods: </strong>This study examined emotional geographies of 15 graduate preservice student teachers of Teacher Training and Education Faculty of Mulawarman University during their teaching practicums. Moreover, this study used a qualitative design involving semi-structured interviews with 15 graduate students who completed their teaching practicums.</p><p><strong>Results: </strong>The participants experienced all emotional geographies (sociocultural, moral, professional, physical, and political) that reshaped their beliefs and teaching styles, especially related to teaching undergraduate students. These emotions are generally experienced when the participants deal with the students and cooperating teachers.</p><p><strong>Conclusions: </strong>It was found that teachers needed to be strict when instilling discipline in their students, develop friendships with their students to maintain classroom control, and require comprehensive preparation to create teacher's confidence and answer their students' questions. In effect, the theoretical framework of emotional geography when teaching undergraduates during practicums gave student teachers valuable experience to cope with all common teaching challenges and professional growth.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"12 ","pages":"505"},"PeriodicalIF":0.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of brain death in wistar rats at different levels of death induction.","authors":"Nayara Maria Gil Mazzante, Fernanda Zuliani, Rogerio Antonio de Oliveira, Júlia Soares Bodaneze, Giovanna Farina Panebianco, Natália Freitas de Souza, Fernando Carmona Dinau, Paola Alejandra Montenegro Cuellar, Nadia Yumi Yamamo Dos Santos, Ana Beatriz de Souza da Silva, Fernanda de Freitas Alves Vieira, Natália Camargo Faraldo, Gabriela Abreu Botelho, Fernanda Barthelson Carvalho de Moura, Noeme Sousa Rocha","doi":"10.12688/f1000research.157233.2","DOIUrl":"10.12688/f1000research.157233.2","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate hematologic, biochemical, and gasometric parameters in Wistar rats to better understand brain death parameters and reduce early misdiagnoses.</p><p><strong>Methods: </strong>Fifteen adult male Wistar rats (Rattus norvergicus; HanUnib: WH) were randomly distributed into three groups of five animals: the control group (G0) with evaluation performed before brain death, and two groups (G1 and G2) with brain death induced at different times: immediately after induction (G1) and one hour after induction (G2). Venous and arterial blood samples were taken to perform complete blood count, biochemical, and blood gas assays. Samples were taken at specific times based on the group each rat belonged to.</p><p><strong>Results: </strong>Statistically significant mean values were observed (P<0,05) for segmented cells (G1>G2 and G0>G2), monocytes (G2>G1 and G0>G1), creatinine (G2>G0), aspartate aminotransferase (G1>G0), potassium (G2>G0), and bicarbonate (G0>G1).</p><p><strong>Discussion: </strong>Furthermore, brain death showed a unique response in each organism, complicating its precise determination even more.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1490"},"PeriodicalIF":0.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting gene expression changes upon epigenomic drug treatment.","authors":"Piyush Agrawal, Vishaka Gopalan, Monjura Afrin Rumi, Sridhar Hannenhalli","doi":"10.12688/f1000research.140273.3","DOIUrl":"10.12688/f1000research.140273.3","url":null,"abstract":"<p><strong>Background: </strong>Tumors are characterized by global changes in epigenetic modifications such as DNA methylation and histone modifications that are functionally linked to tumor progression. Accordingly, several drugs targeting the epigenome have been proposed for cancer therapy, notably, histone deacetylase inhibitors (HDACi) such as vorinostat and DNA methyltransferase inhibitors (DNMTi) such as zebularine. However, a fundamental challenge with such approaches is the lack of genomic specificity, <i>i.e.</i>, the transcriptional changes at different genomic loci can be highly variable, thus making it difficult to predict the consequences on the global transcriptome and drug response. For instance, treatment with DNMTi may upregulate the expression of not only a tumor suppressor but also an oncogene, leading to unintended adverse effect.</p><p><strong>Methods: </strong>Given the pre-treatment transcriptome and epigenomic profile of a sample, we assessed the extent of predictability of locus-specific changes in gene expression upon treatment with HDACi using machine learning.</p><p><strong>Results: </strong>We found that in two cell lines (HCT116 treated with Largazole at eight doses and RH4 treated with Entinostat at 1µM) where the appropriate data (pre-treatment transcriptome and epigenome as well as post-treatment transcriptome) is available, our model distinguished the post-treatment up <i>versus</i> downregulated genes with high accuracy (up to ROC of 0.89). Furthermore, a model trained on one cell line is applicable to another cell line suggesting generalizability of the model.</p><p><strong>Conclusions: </strong>Here we present a first assessment of the predictability of genome-wide transcriptomic changes upon treatment with HDACi. Lack of appropriate omics data from clinical trials of epigenetic drugs currently hampers the assessment of applicability of our approach in clinical setting.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"12 ","pages":"1089"},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding Investor Sentiments in the Indian Stock Market: A Structural Equation Modelling Approach.","authors":"Arvind Nain, N S Borha, Farman Ali, Anu Sayal, Pradeep Suri, Sanjay Singh Chauhan, Vasim Ahmad","doi":"10.12688/f1000research.156635.2","DOIUrl":"10.12688/f1000research.156635.2","url":null,"abstract":"<p><strong>Background of the study: </strong>This research examines how psychological and social biases affect individual investors' investing decisions. Investor sentiment significantly influences financial markets, frequently causing stock prices to deviate from their intrinsic values. In rising economies such as India, where retail investors are significantly affected by psychological factors, comprehending these attitudes is crucial.</p><p><strong>Methods: </strong>This study analyses data from a comprehensive questionnaire that was conducted throughout the nation and included 552 retail investors. The investigation employed structural equation modelling (SEM) to identify the elements that influence the decision-making of individuals who invest in the Indian stock market.</p><p><strong>Findings: </strong>The research offers insight on the influence that investor attitude has on investment decision-making as well as the factors that precede it. The study demonstrates that investors make financial decisions based on sentiment. In addition to assessing the efficacy of the Indian financial market, this study sought to ascertain the rationality of investors' choices by exploring the factors that influence their decision-making process.</p><p><strong>Conclusion: </strong>The outcome of the study shows that information seeking, anchoring, herding, representativeness, and overconfidence all have a big impact on investors. Moreover, the study has proven investors' irrationality and stock market inefficiency. The findings may be employed to further examine the trading practices of international investors and encourage further study in the field of behavioural finance.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1378"},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12107233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}