F1000Research最新文献

{"title":"Hypoglycemic effect of the aqueous extract from <i>Acalypha argomuelleri</i> Briq. (Euphorbiaceae) 'Sweet stick' leaves in <i>Rattus rattus</i> var. <i>albinus</i>.","authors":"Jorge Guillermo Morales Ramos, Berta Loja Herrera, Néstor Manuel Rodríguez Alayo, Doyle Isabel Benel Fernández, Luis Felipe Pérez Medina, Carolina Susana Loayza Estrada, María Ema Soledad Mocarro Willis, César Sánchez Marín","doi":"10.12688/f1000research.164673.3","DOIUrl":"10.12688/f1000research.164673.3","url":null,"abstract":"<p><strong>Introduction: </strong>Diabetes mellitus (DM) is a chronic metabolic disease representing a global public health concern and is associated with severe complications such as cardiovascular and renal diseases. Although several species of the genus <i>Acalypha</i> have demonstrated biological activity, no prior studies have evaluated the hypoglycemic effect of <i>Acalypha argomuelleri</i> Briq., making this study relevant.</p><p><strong>Method: </strong>The hypoglycemic effect of the aqueous leaf extract of <i>A. argomuelleri</i> Briq. (AAAE) was evaluated in an experimental model using <i>Rattus r</i>attus var. albinus (males). A randomized, prospective design was employed, consisting of a control group and three treatment groups receiving doses of 100, 150, and 300 mg/kg of the extract, respectively. Hyperglycemia was induced via oral glucose administration.</p><p><strong>Results: </strong>The qualitative phytochemical analysis of AAAE revealed the presence of flavonoids, phenols, cardiotonic glycosides, and diterpenes, with no reducing sugars. The 300 mg/kg dose produced a significant and sustained reduction in blood glucose levels, reaching near-normal values at 90 minutes, demonstrating a dose- and time-dependent hypoglycemic effect.</p><p><strong>Discussion: </strong>The study confirmed that AAAE has a dose-dependent hypoglycemic effect, with optimal efficacy at 300 mg/kg. This dose showed a faster and more sustained reduction in glucose levels compared to 100 and 150 mg/kg, suggesting higher efficacy at elevated concentrations. The identified flavonoids and phenols, associated with glucose metabolism modulation and pancreatic β-cell protection, likely explain the observed effect. The absence of reducing sugars indicates the hypoglycemic effect is linked to secondary metabolites.</p><p><strong>Conclusions: </strong>The AAAE exhibited a significant dose- and time-dependent hypoglycemic effect, with optimal efficacy at 300 mg/kg after 90 minutes. These findings support the potential of <i>A. argomuelleri</i> Briq. as a natural alternative for blood glucose control, though further studies are needed to assess its safety and efficacy in clinical models.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"800"},"PeriodicalIF":0.0,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12461185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"General anaesthetics reduce acute lymphoblastic leukaemia malignancies <i>in vitro</i> and <i>in vivo</i> <i>via</i> CXCR4 and osteopontin mediated mechanisms.","authors":"Cui Jiang, Sara Gonzalez-Anton, Xiaomeng Li, Emma Mi, Lingzhi Wu, Hailin Zhao, Ge Zhang, Aiping Lu, Cristina Lo Celso, Daqing Ma","doi":"10.12688/f1000research.125877.3","DOIUrl":"https://doi.org/10.12688/f1000research.125877.3","url":null,"abstract":"<p><strong>Background: </strong>Acute lymphoblastic leukaemia (ALL) is a common type of cancer in children. General anaesthetics are often used on patients undergoing painful procedures during ALL treatments but their effects on ALL malignancy remain unknown. Herein, we aim to study the effect of propofol and sevoflurane on the migration, homing and chemoresistance of ALL cells.</p><p><strong>Methods: </strong>NALM-6 and Reh cells were treated with propofol (5 and 10 μg/ml) or sevoflurane (3.6%) <i>in vitro</i> for six hours. Then, cells were harvested for adhesion assay and migration assay <i>in vitro</i>. In <i>in vivo</i> experiments, GFP-NALM-6 cells were pre-treated with propofol (10 μg/ml) or sevoflurane (3.6%) for six hours. Then, cells were injected intravenously to C57BL/6 female mice followed by intravital microscopy. For chemoresistance study, cells were treated with rising concentrations of Ara-c (0.05-50 nM) plus 10μg/ml of propofol or Ara-C plus 3.6% of sevoflurane for 4 hours, followed by the assessment of cell viability via CCK-8 assay and detection of autophagy via flow cytometry.</p><p><strong>Results: </strong>Both anaesthetics reduced <i>in vivo</i> migration and <i>in vivo</i> homing as exemplified by 1) the reduction in the number of cells entering the bone marrow and 2) the disturbance in homing location in relation to endosteal surface. Our results indicated that general anaesthetics reduced the surface CXCR4 expression and the adhesion of leukaemia cells to thrombin cleaved osteopontin (OPN) was reduced. Those changes might result in the alterations in migration and homing. In addition, both anaesthetics sensitised ALL cells to Ara-c possibly through CXCR4 mediated mechanisms. Propofol but not sevoflurane enhanced chemo-related cell death via inducing cytotoxic autophagy.</p><p><strong>Conclusion: </strong>Together, our data suggest that both propofol and sevoflurane could reduce ALL migration, and homing <i>in vivo</i> and <i>in vitro</i> via CXCR4 and OPN mediated mechanisms. Both anaesthetics could sensitise ALL cells to chemotherapy possibly via CXCR4 mediated mechanisms.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"11 ","pages":"1491"},"PeriodicalIF":0.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11128051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145279260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renewable energy: A way out for South Sudan's electricity crisis.","authors":"Aban Ayik, Nelson Ijumba","doi":"10.12688/f1000research.157192.3","DOIUrl":"https://doi.org/10.12688/f1000research.157192.3","url":null,"abstract":"<p><p>South Sudan is one of the least electrified countries in the world, despite having abundant renewable energy resources that could be exploited to generate electricity. The country relies on imported diesel for electricity generation, besides having limited focus on renewable energy development. This policy brief sheds light on the potential of renewable energy as a solution to South Sudan's ongoing electricity crisis. It examines the key factors hindering the development of renewable energy resources for electricity generation in the country. The brief also provides recommendations to the Government of South Sudan, policymakers, experts, and funding institutions on how to improve electricity access in the country. It is stressing on the importance of prioritising the development of diverse renewable energy resources, such as solar, wind, and small hydropower, as an immediate solution to the electricity access challenges in the country.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1267"},"PeriodicalIF":0.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12511852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145279396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health worker delivered Contact and Safety Planning (CASP) for suicide prevention in Chhattisgarh, India: Protocol for a non-randomized, controlled pilot study.","authors":"Sonali Kumar, Sapna Negi, Snehasish Tripathy, Derek deBeurs, Deepa Pandit, Dr Ben Wijnen, Dr Lakshmi Vijayakumar, Laura Shields Zeeman, Soumitra Pathare","doi":"10.12688/f1000research.159494.2","DOIUrl":"10.12688/f1000research.159494.2","url":null,"abstract":"<p><strong>Background: </strong>India records the highest number of suicide deaths globally, but suicide prevention efforts are hindered by a lack of trained personnel within the public health system. Given that an index suicide attempt is a strong predictor of future suicide, intervening with individuals who have recently attempted suicide is a targeted prevention approach that can be delivered within the public health system and has potential to be scaled up across low-resource settings.</p><p><strong>Aim: </strong>To test the implementation and preliminary effectiveness of Contact and Safety Planning (CASP) in reducing suicidal behaviour and symptoms of depression among adults with a recent suicide attempt in Chhattisgarh.</p><p><strong>Methods: </strong>We will carry out a non-randomized, controlled pilot study to evaluate the feasibility, acceptability, adoption, reach, implementation (including cost) and preliminary effectiveness of CASP when delivered by health workers - emergency nurses and Community Health Officers - in two districts of Chhattisgarh (n=250). The control group will receive Enhanced Usual Care, consisting of telephonic counselling by trained District Mental Health (n=250) program staff. Data will be collected at baseline and at 6- and 12-month follow- up.</p><p><strong>Conclusion: </strong>This study will shed light on the feasibility of CASP and inform its further refinement to address suicide at scale in India.</p><p><strong>Trial registration: </strong>Clinical Trials Registry India (CTRI/2022/12/048087) dated 1 October 2022. Link here.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"279"},"PeriodicalIF":0.0,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12508733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145279402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of the season and prevalence of intestinal parasitosis at the Notre Dame de l'Espérance University Hospital Center, Democratic Republic of the Congo.","authors":"Lufuluabu Mpemba Alphonse, Tshishimbi Kalala Jean Hubert, Tshodi Bulanda Arsène","doi":"10.12688/f1000research.160135.3","DOIUrl":"10.12688/f1000research.160135.3","url":null,"abstract":"<p><strong>Background: </strong>Intestinal parasitosis are one of the main causes of morbidity and mortality in Africa. The tropical climate in the D.R. Congo provides parasites with an environment conducive to their proliferation. The prevalence rates of intestinal parasitosis remain poorly understood in the D.R. Congo.</p><p><strong>Objective: </strong>This study aims to estimate the overall and specific prevalence of intestinal parasitosis and to determine an association between intestinal parasitosis and the season at CHUNDE.</p><p><strong>Methods: </strong>From January 1, 2020, to December 31, 2021, patients for whom a direct stool examination was requested at the Notre Dame de l'Espérance University Hospital Center were included in this study. Stool samples were collected and examined under an optical microscope.</p><p><strong>Results: </strong>During the period of the study, we recorded 187 patients aged 2 to 77 years. The prevalence of intestinal parasitosis was 75.40%. The specific prevalence rates for parasites were as follows: <i>E. histolytica/dispar</i>, the most common, with a prevalence of 55.08%, followed by <i>P. hominis</i> and <i>G. lamblia</i> with respective prevalence rates of 9.09% and 6.24%. <i>A. lumbricoide</i> had a prevalence of 27.81%, followed by <i>S. mansoni</i>, <i>A. duodenalis</i>, and <i>E. vermicularis</i> with respective prevalence rates of 3.74%, 1.60%, and 1.07%. There was no association between the season and the overall prevalence of intestinal parasitosis.</p><p><strong>Conclusion: </strong>The prevalence of intestinal parasitosis was higher amang symptomatic patients at CHUNDE. There is no statistically valid association between the season and the prevalence of intestinal parasitosis.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"50"},"PeriodicalIF":0.0,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12511850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145279405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Horizons in Higher Education: Examining the Mental Well-Being of Medical & Health Sciences Students Through the Use of Artificial Intelligence Based Chatbot Platforms in the United Arab Emirates - A Cross-Sectional Comparative Study.","authors":"Eman Abdelaziz Rashad Dabou, Fatma Magdi Ibrahim, Mustafa Faisal Haimour, Aya Saleh, Richard Mottershead","doi":"10.12688/f1000research.166372.2","DOIUrl":"10.12688/f1000research.166372.2","url":null,"abstract":"<p><strong>Background: </strong>Barriers to mental-health care include limited resources and workforce, access constraints, and stigma. Artificial-intelligence (AI)-enabled chatbots may offer low-threshold support.</p><p><strong>Methods: </strong>Cross-sectional correlational (comparative) study in one private health-sciences university in the UAE. Proportional stratified random sampling across four colleges yielded <i>n</i> = 298 undergraduates. Instruments: (i) Socio-Demographic Questionnaire; (ii) researcher-developed AI Chatbot Usability questionnaire (content validated by a bilingual specialist); and (iii) Depression Anxiety Stress Scale-21 (DASS-21; established reliability/validity). Questionnaires were administered face-to-face with standardized instructions.</p><p><strong>Results: </strong>206/298 (69.1%) had ever used an AI chatbot; most used Snapchat AI (76.9%), followed by ChatGPT/Bard (23.4% each). Overall, 57.0% had moderate-to-extremely-severe depression, 68.5% anxiety, and 33.6% stress. Users had higher odds of moderate-to-extremely-severe anxiety and depression than non-users. In multivariable models, higher depression (OR = 1.022; 95% CI 1.01-1.085; <i>p</i><0.001) and anxiety (OR = 1.05; 95% CI 1.01-1.21; <i>p</i><0.001) independently predicted chatbot use; stress did not.</p><p><strong>Conclusion: </strong>Among UAE health-sciences students, AI-chatbot use is common and associated with higher depression/anxiety severity; this likely reflects help-seeking rather than causation. Universities should integrate early, stigma-sensitive supports, potentially including regulated, evidence-based chatbot tools-within stepped-care services.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"665"},"PeriodicalIF":0.0,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Swedish abdominal massage against warm water therapy on postoperative orthopaedic surgery constipation: a comparison quasi-experimental study.","authors":"Enny Selawaty Boangmanalu, Masfuri Masfuri, Muhamad Adam, Sri Nining, Triani Banna, Indira Mastura Pulungan","doi":"10.12688/f1000research.159217.3","DOIUrl":"10.12688/f1000research.159217.3","url":null,"abstract":"<p><strong>Background: </strong>Postoperative immobilization in patients with lower extremity fractures frequently leads to constipation, affecting approximately 50-70% of patients. Non-pharmacological nursing interventions such as Swedish abdominal massage and warm water drinking therapy are potential approaches to alleviate this problem.</p><p><strong>Objective: </strong>The objective of this study was to compare the effectiveness of Swedish abdominal massage and warm water drinking therapy in reducing constipation scores among patients with postoperative lower extremity fractures.</p><p><strong>Methods: </strong>A quasi-experimental pre-posttest design without a control group was conducted with 30 respondents selected using a simple random sampling technique. Constipation was assessed using the Constipation Assessment Scale (CAS) before and after intervention. Data were analyzed using independent <i>t</i>-tests, and results were interpreted with attention to baseline differences between groups.</p><p><strong>Results: </strong>Both interventions significantly reduced constipation scores. The mean post-intervention CAS score was 4.60 in the warm water group and 3.56 in the Swedish abdominal massage group ( <i>p</i> < 0.001). Although Swedish abdominal massage showed a greater within-group reduction, baseline imbalances in constipation scores may have influenced the observed differences.</p><p><strong>Conclusion: </strong>Swedish abdominal massage and warm water therapy are effective nurse-led, non-pharmacological interventions for reducing postoperative constipation. The findings should be interpreted cautiously due to baseline differences and small sample size. Future research with larger samples, controlled designs, and statistical adjustments is recommended to confirm these preliminary findings.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1531"},"PeriodicalIF":0.0,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12340488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the Intellectual Landscape of Employee Performance Research: A Bibliometric and Mapping Analysis (2020-2025).","authors":"Maryadi Maryadi, Hamidah Nayati Utami, Arik Prasetya, Benny Hutahayan","doi":"10.12688/f1000research.165774.2","DOIUrl":"10.12688/f1000research.165774.2","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to identify research trends and map the academic structure in the field of employee performance over the past five years. Given the increasing complexity of organizations and post-pandemic work dynamics, bibliometric mapping is necessary to understand the evolution of themes, the contributions of key literature, and the future directions of knowledge development.</p><p><strong>Design/methodology/approach: </strong>A total of 2,044 articles published between 2020 and 2025 are collected from the Scopus database. The article selection process adheres to the PRISMA 2020 guidelines to ensure transparency and methodological rigor. Analysis is conducted using Bibliometrix R and VOSviewer, employing performance analysis and science mapping techniques. Visualization results include trending topics, a word cloud, the most globally cited documents, and network visualizations identifying the primary thematic clusters within the literature.</p><p><strong>Findings: </strong>The findings indicate that research topics are shifting from general issues toward contemporary themes such as digital leadership, work well-being, and organizational adaptation to global changes. Seven primary clusters are identified, reflecting a multidisciplinary approach encompassing structural, psychological, and contextual dimensions. Additionally, articles with high normalized citation scores demonstrate that significant contributions come from practical and cross-sectoral studies.</p><p><strong>Originality/value: </strong>The novelty of this study lies in mapping the intellectual structure and research trends of employee performance using Bibliometrix R and VOSviewer, focusing on the post-pandemic period (2020-2025). It uniquely employs trending topics and normalized citation analysis to identify emerging themes and influential publications in contemporary research.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"633"},"PeriodicalIF":0.0,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12508735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145279383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors predicting outcome in cervical lymph node tuberculosis: insights from a Tunisian case series.","authors":"Maissa Lajhouri, Selima Jouini, Yosra Ammar Mnejja, Azza Mediouni, Rihab Lahmar, Houda Chahed","doi":"10.12688/f1000research.164097.2","DOIUrl":"10.12688/f1000research.164097.2","url":null,"abstract":"<p><strong>Background: </strong>Tuberculosis remains a significant public health issue in Tunisia. This study aimed to describe the epidemiological, clinical, and therapeutic characteristics of cervical lymph node tuberculosis and identify factors influencing outcomes.</p><p><strong>Methods: </strong>A retrospective study was conducted over a 3-year period in the ENT department at La Rabta Hospital, Tunis. Diagnosis was based on histopathological evidence, and disease progression was categorized as favorable (treatment <9 months, no additional surgery) or unfavorable (treatment >9 months and/or supplementary surgery).The study population was divided into two groups based on the outcome nature, and analytical analysis was performed to assess factors influencing outcomes.</p><p><strong>Results: </strong>The study included 102 patients (32 men and 70 women), with a median age of 34.5 years (range: 8-83 years). Most patients (78.4%) had no significant medical history or known HIV infection. Thirty-nine patients (38.2%) had a history of consuming raw milk. In 65 cases (63.7%), lymph node size exceeded 3 cm. Hypoechogenicity (53.9%) and necrosis (40.1%) were the most common findings on ultrasound and CT scan, respectively. The initial diagnostic approach included adenectomy (56.8%), lymph node dissection (8.9%), and drainage of cold abscesses (34.3%). All patients received an initial four-drug antituberculosis regimen. Ethambutol treatment was extended beyond 2 months in 65 cases (63.7%). Fifty-six patients (54.9%) had a favorable outcome.Factors associated with a favorable outcome included intact skin, complete initial lymph node dissection, favorable progress at 2 months, and prolonged ethambutol therapy.</p><p><strong>Conclusions: </strong>The management of lymph node tuberculosis remains challenging, especially with insufficient bacteriological confirmation. Regional epidemiological factors should be considered. The role of surgery is crucial; however, further standardization is needed to optimize patient outcomes.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"511"},"PeriodicalIF":0.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12498516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sentiment analysis of internet posts on vaccination using ChatGPT and comparison with actual vaccination rates in South Korea.","authors":"Sunyoung Park","doi":"10.12688/f1000research.145845.4","DOIUrl":"10.12688/f1000research.145845.4","url":null,"abstract":"<p><strong>Background: </strong>This study used ChatGPT for sentiment analysis to investigate the possible links between online sentiments and COVID-19 vaccination rates. It also examines Internet posts to understand the attitudes and reasons associated with vaccine-related opinions.</p><p><strong>Methods: </strong>We collected 500,558 posts over 60 weeks from the Blind platform, mainly used by working individuals, and 854 relevant posts were analyzed. After excluding duplicates and irrelevant content, attitudes toward and reasons for vaccine opinions were studied through sentiment analysis. The study further correlated these categorized attitudes with the actual vaccination data.</p><p><strong>Results: </strong>The proportions of posts expressing positive, negative, and neutral attitudes toward COVID-19 vaccines were 5%, 83%, and 12%, respectively. The total post count showed a positive correlation with the vaccination rate, indicating a high correlation between the number of negative posts about the vaccine and the vaccination rate. Negative attitudes were predominantly associated with societal distrust and perceived oppression.</p><p><strong>Conclusions: </strong>This study demonstrates the interplay between public perceptions of COVID-19 vaccines as expressed through social media and vaccination behavior. These correlations can serve as useful clues for devising effective vaccination strategies.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"96"},"PeriodicalIF":0.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12179586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}