F1000Research最新文献

{"title":"Exploring needs, perceptions, and preferences towards exercise video among overweight individuals - a qualitative study.","authors":"Shishira K B, K Vaishali, Rajagopal Kadavigere, Suresh Sukumar, Shivashankara K N, Samuel A Pullinger, Tulasiram Bommasamudram, Praveen Hoogar","doi":"10.12688/f1000research.150772.3","DOIUrl":"10.12688/f1000research.150772.3","url":null,"abstract":"<p><strong>Background: </strong>The number of overweight people (BMI 25-29.9kg.m ^-2) in the world is increasing, which increases the risk of health problems and psychological difficulties. To reduce these risks, it is imperative to address unhealthy habits including food and exercise. This qualitative study aimed to explore the needs, perceptions, and preferences of overweight individuals on tailored exercise programs that incorporate educational videos.</p><p><strong>Methodology: </strong>Forty Individuals between the age of 18-30 years with a BMI of 25-29.9kg.m ^-2 were included in the study using Purposive sampling from October 2023 to November 2023. Semi-structured in-depth interview was conducted for 45-60 minutes approximately among both active and inactive overweight individuals by a researcher trained in qualitative research. These interviews were audio-recorded and transcribed verbatim. Thematic analysis was performed using inductive and deductive approaches to identify the recurrent patterns, themes, and insights in the transcribed interviews.</p><p><strong>Results: </strong>8 themes, such as lifestyle factors, exercise explorations, holistic wellbeing and 44 subthemes emerged from the analysis, helping to shed light on the needs, perceptions, and preferences that overweight individuals experience when it comes to their preference for a customized exercise program provided through educational video. The participants wanted personalized regimens that catered to their requirements and levels of fitness.</p><p><strong>Conclusion: </strong>In summary, the findings emphasize the value of educational videos that are easy to use, visually appealing, and supported by science. These videos should emphasize technique, varying levels of difficulty, and brief sessions.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"998"},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological characteristics and hospital outcomes of hospitalized Lassa fever cases during the 2022-2023 outbreak in Liberia.","authors":"Emmanuel Dwalu, Hannock Tweya, Mher Beglaryan, Chukwuma D Umeokonkwo, Ralph W Jetoh, Bode I Shobayo, Fahn Tarweh, Philip Owiti, Pryanka Relan, Shermarke Hassan, George W Goteh, Darius B Lehyen, Louis Ako-Egbe, Ibrahim Franklyn Kamara, Godwin E Akpan, Peter Adewuyi, Patrick N Kpanyen, Benjamin T Vonhm, Julius S M Gilayeneh","doi":"10.12688/f1000research.150743.2","DOIUrl":"10.12688/f1000research.150743.2","url":null,"abstract":"<p><strong>Background: </strong>Lassa fever (LF) is an endemic and immediately notifiable disease in Liberia, and one laboratory confirmed case constitutes an outbreak. We described the epidemiological characteristics and hospital outcomes of LF cases hospitalized during the 2022-2023 outbreak in Liberia.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted using routine LF surveillance data from the 2022-2023 outbreak in Liberia. Descriptive statistics were used to summarize the data and log binomial regression to assess the association between epidemiological characteristics and mortality.</p><p><strong>Results: </strong>A total of 439 suspected LF cases were reported. The median age was 22 (interquartile range (IQR): 10-33) years and 233 (53%) were females. The median number of days between symptom onset and admission was 4 (IQR 2-7). Of the 439 cases, 416 (95%) were tested for LF and 138 were confirmed with 33% positivity rate. The majority, 95 (69%), of confirmed cases were <30 years, 78 (57%) were females, and 81 (59%) were reported during the dry season (October - March). Contact with rodents, 95 (69%), was the commonest mode of exposure. Fever, 128 (93%), malaise, 121 (88%), headache, 114 (83%) and myalgia, 114 (83%) were the most common clinical presentations. There were 83 (19%) deaths among hospitalized suspected LF cases - 42 deaths (15%) among 278 individuals who tested negative and 41 among confirmed cases with 30% case fatality rate (CFR). Presenting CFR per age group, age 40-49 years accounted for 8/12 (67%) and those aged≥50 reported 5/8 (63%) of the deaths among the confirmed cases. There was no significant association between epidemiological characteristics and LF mortality.</p><p><strong>Conclusions: </strong>The outbreak highlighted a high disease burden of LF with young adults disproportionately infected, and mortality, even among those who tested negative for the virus. This underscores the urgent need for preventive measures like vaccines and health education campaigns.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"661"},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12150276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential effects of cranberry extract on indomethacin-induced gastric ulcer in rats.","authors":"Zaid Abdul-Majeed, Mohammed Qasim Yahya Malallah A Al-Atrakji","doi":"10.12688/f1000research.158944.1","DOIUrl":"10.12688/f1000research.158944.1","url":null,"abstract":"<p><strong>Background: </strong>Indomethacin belongs to nonsteroidal anti-inflammatory drugs (NSAIDs) prescribed for treatment of rheumatoid diseases and linked to the development of gastric ulcers in many people. Cranberry is a rich source of polyphenols and flavonoids, which have powerful antioxidant and anti-inflammatory properties.</p><p><strong>Methods: </strong>This study aimed to evaluate the activity of cranberry aqueous extract on indomethacin-induced gastric ulcers in albino rats. 20 adult male rats were sequentially assigned to four groups of 5 each. The control group consumes distilled water (DW) orally for 15 days. The induction group received a single oral dosage (60 mg/kg) of IND. The omeprazole group got 60 mg/kg of indomethacin as a single oral dose and then 20 mg/kg/day of omeprazole for 15 days. The cranberry group was given a single dose of indomethacin 60 mg/kg orally and subsequently 200 mg/kg/day of cranberry aqueous extract for 15 days. Rats were euthanized on day 15, and gastric tissues were removed for biochemical and histopathological evaluations.</p><p><strong>Results: </strong>Cranberry extract considerably ameliorated the severity of indomethacin-induced gastric ulcerations and fixed histological deteriorations. Furthermore, indomethacin-exposed rats treated with cranberry extract exhibited dramatically lower serum levels of inflammatory biomarkers like TNF-α and IL-6, but higher levels of anti-oxidative biomarkers like SOD and GPx. The bioactive flavonoids and polyphenols content of cranberry extract could possibly account for its profound gastroprotective effects. The anti-oxidative and anti-inflammatory properties of cranberry extract could be a promising strategy for ameliorating the indomethacin-aggravated gastrotoxicity.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"257"},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing vehicle performance through the application of airfoils as spoilers with movable trailing edge.","authors":"Ahmad Karaki, Mohammad Abu Sirreya, Majdi Zalloum, Husein Amro","doi":"10.12688/f1000research.160307.2","DOIUrl":"10.12688/f1000research.160307.2","url":null,"abstract":"<p><strong>Background: </strong>Vehicle safety and stability are critical in the automotive industry, with aerodynamics playing a key role in enhancing these attributes. Spoilers, when effectively designed, can significantly influence airflow, downforce, and lift. This study investigates the aerodynamic performance of spoilers modeled as airfoils with adjustable trailing edges, aiming to dynamically control aerodynamic forces and improve vehicle stability and performance.</p><p><strong>Methods: </strong>Computational Fluid Dynamics (CFD) simulations were conducted using ANSYS Fluent® to analyze the impact of varying trailing edge angles (AOTE) on aerodynamic forces. A detailed Tesla vehicle model was created in CATIA™, and simulations were performed across a speed range of 120-350 km/h. The Shear Stress Transport (SST) <i>k-ω</i> turbulence model was employed to ensure accurate flow prediction. A wind tunnel domain and grid independence validation were used to ensure numerical reliability. Boundary conditions included velocity inlets, pressure outlets, and no-slip wall boundaries.</p><p><strong>Results: </strong>Adjusting the trailing edge angle produced significant variations in lift and downforce. At an angle of 30°, the negative lift (downforce) increased by up to 36%. At 0°, it increased by up to 17%. During acceleration phases, the controlled generation of positive lift improved aerodynamic efficiency, yielding a total lift increase of up to 15%. The simulated drag coefficient was 0.256, differing by 6% from Tesla's reported value of 0.24, primarily due to mesh refinement level and geometric simplifications.</p><p><strong>Conclusions: </strong>This study demonstrates that a spoiler with a movable trailing edge can significantly enhance vehicle handling, acceleration, and aerodynamic stability by actively modulating lift and downforce. The findings support the integration of active aerodynamic control systems in vehicle design. Future research will focus on control system development and experimental validation under real-world driving conditions.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"469"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A causality investigation into stock prices and macroeconomic indicators in the Indian stock market.","authors":"Sanjay Singh Chauhan, Pradeep Suri, Firoz Alam, Umme Hani, Amar Johri, Farman Ali","doi":"10.12688/f1000research.157041.3","DOIUrl":"https://doi.org/10.12688/f1000research.157041.3","url":null,"abstract":"<p><strong>Background of the study: </strong>The systematic impact of macroeconomic variables on stock market returns makes it crucial to comprehend the link between macroeconomic variables and the stock market. Stock prices are closely linked to macroeconomic indicators, a crucial aspect for investors, policymakers, and researchers in emerging markets like India, influencing investment decisions and policy formulation.</p><p><strong>Methods: </strong>The autoregressive distributed lag (ARDL) model was used in this study to examine the causal links between specific macroeconomic factors and Indian stock prices from April 2009 to March 2023.</p><p><strong>Results: </strong>The outcomes of the research suggest that macroeconomic variables exert influence on the Indian stock market, across the short and long term. Moreover, the results of the paired Granger causality test suggest that the domestic macroeconomic variables possess predictive significance for stock prices in the Indian stock market.</p><p><strong>Conclusion: </strong>The study reveals that macroeconomic variables significantly impact the Indian stock market, highlighting the need for investors and portfolio managers to monitor these conditions to optimize returns and mitigate risks. The Reserve Bank of India should maintain an optimal money supply to prevent inflation and exchange rate fluctuations, while bolstering the export sector and facilitating imports through initiatives like Atma-nirbhar Bharat Abhiyan and Make in India. Policies focusing on productivity, infrastructure, and a favourable business environment are also crucial. Therefore, it is crucial for investors and portfolio managers to consistently analyse the current macroeconomic conditions in order to maximize their profits and minimize risks. This research has extensive significance for comprehending the intricate connections between the stock market and macroeconomic issues.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1299"},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric Evaluation of the Thai Version of the Burdened Caregiver Scale for Schizophrenia and Co-occurring Methamphetamine Use: A Pilot Study.","authors":"Ek-Uma Imkome","doi":"10.12688/f1000research.52288.3","DOIUrl":"10.12688/f1000research.52288.3","url":null,"abstract":"<p><strong>Objective: </strong>To develop and test the psychometric properties of the Thai version of the Impact and Burden of Care Scale for Caregivers of Persons with Schizophrenia and Co-occurring Methamphetamine Use (TIBSCSM).</p><p><strong>Methods: </strong>This pilot study involved 142 caregivers of individuals with schizophrenia and methamphetamine use. Sample adequacy was assessed using the Kaiser-Meyer-Olkin (KMO) method, while Bartlett's test evaluated the item correlation matrix. Exploratory factor analysis (EFA) was conducted to identify underlying factors.</p><p><strong>Results: </strong>The 32-item TIBSCSM showed convergent validity correlations with two quality-of-life measures. The KMO value was 0.90, and Bartlett's Test of Sphericity yielded χ ² = 5248.5, df = 496, p < 0.001. The Content Validity Index (CVI) was 1, indicating high internal consistency reliability (α = 0.90). EFA identified four constructs: physical function, self-esteem, role and social enjoyment, and relationship satisfaction. The model exhibited strong reliability and validity, with an average variance extracted (AVE) of 0.948 and composite reliability (CR) of 0.987, accounting for 64.90% of the variance.</p><p><strong>Conclusion: </strong>The TIBSCSM scale provides valuable insights for psychiatric nurses and mental health teams to measure the impact and burden experienced by caregivers of individuals with schizophrenia and methamphetamine use. It is particularly useful for nursing, research, education, and clinical practice, especially in addressing the caregiver burdens exacerbated during the COVID-19 pandemic.</p><p><strong>Implication for nursing and research: </strong>The TIBSCSM, developed in the Thai context, can facilitate studies evaluating variations in caregiver impact across different settings.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"10 ","pages":"484"},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Influencing Organisational Politics and their Relationship with Emotional Intelligence and Employee Behavior: A PLS-SEM Modelling.","authors":"Sonakshi Bhatia, Babita Rawat, Dhani Shanker Chaubey, Farman Ali","doi":"10.12688/f1000research.151721.2","DOIUrl":"10.12688/f1000research.151721.2","url":null,"abstract":"<p><strong>Background: </strong>This study explores the complex relationship between organizational politics, emotional intelligence and employee behavior in contemporary settings. Organizational politics, which is widespread in organizational settings, has a substantial impact on different aspects of employee behavior. Emotional Intelligence has become a vital factor in individuals' capacity to successfully traverse the complexities of an organization. This study consolidates current material to offer insights into the impact of organizational politics on employee behavior and the mediating role of emotional intelligence in this connection.</p><p><strong>Methods: </strong>A survey was undertaken with a sample size of 500 employees hailing from several Information Technology (IT) and Information Technology Enabled Services (ITES) firms in the Dehradun (Uttarakhand) region. The study employed quantitative methodologies to investigate the correlations between Emotional Intelligence, Perceived Organizational Politics and Employee Behavior. The data were evaluated using Partial Least Squares Structural Equation Modelling (PLS-SEM) to examine the hypothesized correlations and mediation effects.</p><p><strong>Results: </strong>The study identified substantial correlations between Emotional Intelligence, Perceived Organizational Politics, and Employee Behavior. Emotional Intelligence was discovered to have a positive impact on Behavioral Dynamics. Perceived Organizational Politics had a substantial influence on both Emotional Intelligence and Behavioral Dynamics. Factors such as Need for Power, Relationship Conflict, Resource Constraints, Role Conflict, and Workforce Diversity were discovered to have an impact on Perceived Organizational Politics.</p><p><strong>Conclusions: </strong>The results confirm strong connections between organizational politics, emotional intelligence, and employee behavior, highlighting the significance of these concepts in comprehending employee behavior in organizational environments. The study proposes that enhancing employees' emotional intelligence can alleviate the adverse effects of organizational politics, resulting in enhanced behavioral dynamics. The study also addresses the limits, outlines potential areas for further research, and highlights the managerial implications. It suggests that firms should prioritize the development of emotional intelligence to cultivate a favorable work environment.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"996"},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: A giant ruptured splenic hydatic cyst in a patient with a complete situs inversus: Diagnostic challenge and intra-operative difficulties.","authors":"Amina Chaka, Wael Boujelbène, Amin Chaabouni, Mohamed Ali Bahloul, Nizar Kardoun, Salah Boujelben","doi":"10.12688/f1000research.159480.2","DOIUrl":"10.12688/f1000research.159480.2","url":null,"abstract":"<p><p>The splenic localization of hydatid cysts is extremely rare. A 50-year-old obese female who consults with a painful and febrile syndrome of the right hypochondrium. Abdominal ultrasound and a CT scan computed tomography revealed a complete situs inversus, a mass of the right hypochondrium measuring 152 mm with membrane detachment, and infiltration of the surrounding fat, evoking a type II complicated splenic hydatic cyst. The patient was operated on in an emergency via midline laparotomy. Exploration revealed situs inversus, an angiant cyst of the spleen. Exposition of the splenic pedicle is difficult. The samples were then infected. Total splenectomy was performed. The postoperative period was unproblematic, and the patient was discharged with antibiotic and antiparasitic treatment and habitual vaccination.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1480"},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hybrid optimization technique for matrix chain multiplication using Strassen's algorithm.","authors":"Srinivasarao Thota, Thulasi Bikku, Rakshitha T","doi":"10.12688/f1000research.162848.1","DOIUrl":"10.12688/f1000research.162848.1","url":null,"abstract":"<p><strong>Background: </strong>Matrix Chain Multiplication (MCM) is a fundamental problem in computational mathematics and computer science, often encountered in scientific computing, graphics, and machine learning. Traditional MCM optimization techniques use Dynamic Programming (DP) with Memoization to determine the optimal parenthesization for minimizing the number of scalar multiplications. However, standard matrix multiplication still operates in O(n ³) time complexity, leading to inefficiencies for large matrices.</p><p><strong>Methods: </strong>In this paper, we propose a hybrid optimization technique that integrates Strassen's algorithm into MCM to further accelerate matrix multiplication. Our approach consists of two key phases: (i) matrix chain order optimization, using a top-down memoized DP approach, we compute the best multiplication sequence, and (ii) hybrid multiplication strategy, we selectively apply Strassen's algorithm for large matrices (n ≥ 128), reducing the complexity from O(n ³) to O(n ^2.81), while using standard multiplication for smaller matrices to avoid recursive overhead. We evaluate the performance of our hybrid method through computational experiments comparing execution time, memory usage, and numerical accuracy against traditional MCM and Strassen's standalone multiplication.</p><p><strong>Results: </strong>Our results demonstrate that the proposed hybrid method achieves significant speedup (4x-8x improvement) and reduces memory consumption, making it well-suited for large-scale applications. This research opens pathways for further optimizations in parallel computing and GPU-accelerated matrix operations.</p><p><strong>Conclusion: </strong>This study presents a hybrid approach to Matrix Chain Multiplication by integrating Strassen's algorithm, reducing execution time and memory usage. By selectively applying Strassen's method for large matrices, the proposed technique improves efficiency while preserving accuracy. Future work can focus on parallel computing and GPU acceleration for further optimization.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"341"},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12000801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In vitro</i> antitumor capacity of extracts obtained from the plants <i>Plukenetia volubilis</i> (Sacha inchi) and <i>Moringa oleifera</i> in gastric cancer.","authors":"Jose Vargas, Natalia Arbelaez, Denny Cardenas, Javier Murillo, Victoria Ospina, Sara Robledo, Javier Soto","doi":"10.12688/f1000research.158563.2","DOIUrl":"10.12688/f1000research.158563.2","url":null,"abstract":"<p><strong>Background: </strong>Gastric cancer is the fifth most common cancer and the third leading cause of cancer deaths worldwide. Perioperative or adjuvant chemotherapy improves survival in patients with stage 1B or higher cancers. <i>Moringa oleifera</i> and <i>Plukenetia volubilis</i> (Sacha inchi) have been reported to enhance various biological functions, including antitumor and antiproliferative activity.</p><p><strong>Methods: </strong>In order to evaluate this potential present in crude extracts of the leaves of these plants, as well as the seed oil of <i>P.volubilis</i>, the antitumor activity was determined according to the effect of these derivatives on different biological parameters such as cytotoxicity, proliferation, cell cycle, apoptosis (among others), in AGS cells (CRL-1739).</p><p><strong>Results: </strong>All extracts tested were cytotoxic at 90 and 160 μg/ml concentrations <i>. P. volubilis</i> seed oil showed 95% mortality at 1% concentration (CC ₅₀ = 46.7%). Cell proliferation was inhibited, and all extracts affected the cell cycle, but the <i>P. volubilis</i> oil significantly induced an accumulation of AGS cells in the sub G1 phase, inducing DNA fragmentation as a mechanism of cell death. The ethanolic <i>M. oleifera</i> leaf extract also inhibited cell migration.</p><p><strong>Conclusion: </strong><i>M. oleifera</i>, <i>P. volubilis</i> leaf extracts and <i>P. volubilis</i> seed oil can potentially be antitumor products. Further validation in a murine model of gastric cancer is needed to investigate the antitumor potential of these extracts further and to continue the development of herbal products that can help in the management of this type of tumor.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"194"},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}