F1000Research最新文献

{"title":"Prevalence of <i>Candida albicans</i> in the oral cavity of Beta Thalassemia Major and Thalassemia Minor Patients.","authors":"Saba Sami Abd Al Wahab, Maha Adel Mahmood","doi":"10.12688/f1000research.162460.2","DOIUrl":"10.12688/f1000research.162460.2","url":null,"abstract":"<p><strong>Aims: </strong>To examine the correlation between iron, ferritin concentrations, and <i>C. albicans</i> infection in individuals with beta-thalassemia major and beta-thalassemia minor compared with healthy subjects.</p><p><strong>Materials and methods: </strong>It involved 90 participants, thirty patients with thalassemia major and thirty patients with thalassemia minor compared with thirty healthy controls. Saliva samples were obtained and cultivated to isolate, identify, and calculate the viable colony count of <i>C. albicans</i> in (cfu/ml). In contrast, serum levels of iron and ferritin were quantified using chemical analyzers.</p><p><strong>Result: </strong>Showed that 73.33% of thalassemia major group exhibited oral <i>C. albicans</i> colonization, which is significantly higher than that of thalassemia minor group 40% and control group 6.67%. Biochemical analyses revealed significantly higher iron 278.82 μg/dl and ferritin 2783.80 ng/ml levels in major group p<0.001 when compared with both thalassemia minor group 122.652 μg/dl, 74.723 ng/ml and control groups 127.438 μg/dl and 63.150 ng/ml respectively. <i>C. albicans</i> colony count in saliva was significantly elevated in beta-thalassemia major, as compared with beta-thalassemia minor group and control group.</p><p><strong>Conclusion: </strong>Findings suggest that iron overload, which results from recurrent blood transfusions and causes immune dysfunction, contributes to higher risk of oral fungal infections in Beta-thalassemia patients compared with controls.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"555"},"PeriodicalIF":0.0,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144872125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The distribution of groundwater uranium in Chintamani village, Karnataka, India.","authors":"Sadashiva Rampur, Mahesh Kumar V K, Pavan R Pelli, Senjuti Sarkar, Samayeta Pramanik, Upama Majumder, Shravanthi S, Bhavana Meenakshi T, Srinidhi G Santhanakrishnan, Rushi Pendem, Tanushree Ghosh, Deepesh Nagarajan","doi":"10.12688/f1000research.162525.3","DOIUrl":"10.12688/f1000research.162525.3","url":null,"abstract":"<p><strong>Background: </strong>Chintamani village, Chikkaballapura district, Karnataka, India was found to possess high aquifer uranium concentrations. Geologically, Chintamani village is located on bedrock that is rich in elements like potassium (K) that naturally contain high levels of radioactive elements, such as uranium and thorium, due to the presence of alkali-feldspar granites and gneisses. Aquifer depletion has caused the concentration of these elements in groundwater to increase over time, posing a potential health hazard to the residents of Chintamani village.</p><p><strong>Methods: </strong>Here, we report the sampling of groundwater from 12 borewells located in Chintamani village in between the period of August 2024 to December 2024. We observed groundwater uranium concentrations of 0.018 ppm to 8.64 ppm. Data for borewell depth, the quantity of total dissolved solids (TDS), and the elemental composition of TDS is also reported. We observed a statistically significant spatial distribution of uranium concentrations in Chintamani village. Borewells possessing the highest observed concentrations of uranium were clustered towards the northwestern region of the village.</p><p><strong>Conclusions: </strong>This dataset is expected to serve as a resource for guiding potential remediation efforts in these locations.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"321"},"PeriodicalIF":0.0,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145014169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in sleep dentistry research in Asia: A bibliometric analysis.","authors":"Faizul Hasan, Mokh Sujarwadi, Lia Taurussia Yuliana, Ervina Restiwulan Winoto, An'nisaa Chusida, Hendrik Setia Budi","doi":"10.12688/f1000research.164414.2","DOIUrl":"10.12688/f1000research.164414.2","url":null,"abstract":"<p><strong>Background: </strong>Sleep-related conditions such as obstructive sleep apnea and bruxism significantly affect both oral and systemic health, posing substantial public health challenges. Growing scholarly interest in sleep dentistry reflects an emerging effort to address these conditions through multidisciplinary research. This study employs bibliometric analysis to examine emerging themes, collaborative patterns, influential authors, and research trajectories related to sleep dentistry in Asia.</p><p><strong>Methods: </strong>A comprehensive search was conducted using the Scopus database to identify relevant publications from inception through April 2025. Bibliometric techniques were applied to analyze co-authorship networks, annual publication trends, institutional and international collaborations, keyword co-occurrence, and citation metrics. VOSviewer and the Bibliometrix package in R were utilized for data visualization and network mapping.</p><p><strong>Results: </strong>The analysis included 1,237 publications. China was the leading contributor, followed by the United States and India. The United Kingdom exhibited the highest ratio of Multiple Country Publications, followed by Australia and Canada. Tehran University of Medical Sciences emerged as the most productive institution, followed by the All India Institute of Medical Sciences and Shahid Beheshti University of Medical Sciences. Co-authorship analysis revealed six distinct collaborative clusters, with a total of 5,828 scholars contributing to the field.</p><p><strong>Conclusion: </strong>A substantial and growing body of research on sleep dentistry has emerged in Asia. The bibliometric findings highlight influential contributors, international cooperation, and key research themes particularly obstructive sleep apnea and bruxism underscoring the value of bibliometric methods in shaping responses to this pressing regional public health concern.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"489"},"PeriodicalIF":0.0,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12355164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144872126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research trends in mobile payment adoption: Research trends and agenda.","authors":"Alejandro Valencia-Arias, Jesus Alberto Jimenez Garcia, Gustavo Moreno-López, Aaron José Alberto Oré León, Lucia Palacios-Moya, Jackeline Valencia, Martha Benjumea-Arias","doi":"10.12688/f1000research.159551.2","DOIUrl":"10.12688/f1000research.159551.2","url":null,"abstract":"<p><p>This study explores the adoption of mobile payments as a research field to understand the technological, socioeconomic, and cultural factors that influence the understanding of the users' experience and satisfaction and attract more users. It is vital to examine the research trends in the adoption of mobile payments from a systematic literature review using PRISMA 2020 to select 63 documents from Scopus and WOS. Among the results, the most used models for this analysis are extended TAM and extended UTAUT. The most representative variables in the studies are social influence, security perception, risk perception, trust and perceived usefulness. It is concluded that the future research agenda should focus on topics such as biometric authentication, payment flexibility and contactless payments. In addition, from the business perspective, there is a focus on designing innovative interfaces that are more intuitive for users.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"358"},"PeriodicalIF":0.0,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12405856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review the role of oxygen-delivering nanobubbles in stroke therapy: A novel approach.","authors":"Hamzah Hamzah, Suryanti Suryanti, Idris Adewale Ahmed, Bambang Pujo Semedi, Abdullah Machin, Aditya Tri Hernowo","doi":"10.12688/f1000research.162742.3","DOIUrl":"10.12688/f1000research.162742.3","url":null,"abstract":"<p><p>Stroke remains a leading cause of mortality and long-term disability worldwide, necessitating innovative therapeutic strategies. The advent of nanotechnology, particularly oxygen-delivering nanobubbles (ODNBs), has introduced a promising avenue for enhancing stroke therapy. ODNBs have demonstrated the ability to improve oxygen delivery, enhance therapeutic efficacy, and provide diagnostic advantages through imaging contrast enhancement. However, challenges such as toxicity, off-target effects, and regulatory hurdles must be addressed before clinical translation. This review synthesizes the latest findings on ODNBs in stroke therapy, highlights their key benefits and challenges, and explores future applications, including gene therapy and brain tissue regeneration. By addressing these aspects, this review aims to provide a comprehensive understanding of the potential of ODNBs in revolutionizing stroke treatment.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"406"},"PeriodicalIF":0.0,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12405841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodology for generating chorioallantoic membrane patient-derived xenograft (CAM-PDX) models of pleural mesothelioma and performing preclinical imaging for the translation of cancer studies and drug screening.","authors":"Jan Schulze, Sarah Barnett, Liam Shaw, Anne Herrmann, Harish Poptani, Doris M Rassl, Alexander Haragan, Michael Shackcloth, Joseph J Sacco, Judy M Coulson","doi":"10.12688/f1000research.163596.2","DOIUrl":"10.12688/f1000research.163596.2","url":null,"abstract":"<p><strong>Background: </strong>Pleural mesothelioma is a cancer of the lung lining associated with asbestos exposure. Platinum/pemetrexed chemotherapy has been used for many years but provides little benefit and, despite recent immunotherapy advances, prognosis remains poor underpinning the need for development of novel therapeutics or drug repurposing. Fertilized hens' eggs provide a rapid and cost-effective alternative to murine models of pleural mesothelioma which are commonly used in preclinical studies, with chorioallantoic membrane (CAM) xenografts being a partial replacement for mouse flank xenografts. Here we describe methods to generate mesothelioma patient-derived xenografts on the CAM (CAM-PDX), and to subsequently assess these PDX nodules by preclinical imaging and histology.</p><p><strong>Methods: </strong>Fragments of surplus mesothelioma tissue obtained from patient biopsies were implanted onto the CAM on embryonic day 7 (E7), fresh or following cryopreservation, with the established PDX dissected on E14 and fixed for histological/immunohistochemical analysis. The optimal freezing method was determined by comparing tissue integrity and cellular content of cryopreserved tissue fragments with paired fresh samples via histological/immunohistochemical analyses. [ ¹⁸F]-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) was used to assess viability of PDXs <i>in ovo.</i></p><p><strong>Results: </strong>Methodologies for processing, cryopreservation, re-animation, and engraftment of mesothelioma tissue fragments were established. Cryopreservation of biopsy samples and parallel processing of contiguous sections allows for assessment of mesothelioma cellularity. CAM-PDXs, generated from fresh or slow-frozen tissue, were well vascularized whilst maintaining the architecture and cellular composition of the patient tissue. Furthermore, uptake of [ ¹⁸F]-FDG following intravenous injection could be visualized and quantified.</p><p><strong>Conclusions: </strong>The CAM is a rapid platform for engrafting patient-derived tissue, maintaining elements of the tumor microenvironment and recapitulating heterogeneity observed in mesothelioma. Combining the CAM-PDX model and FDG-PET/CT provides a quantitative <i>in vivo</i> platform for pre-screening of novel treatment strategies and drug combinations, with the potential for development of patient tumor avatars for predicting clinical response.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"481"},"PeriodicalIF":0.0,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144495434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of thermocycling on flexural strength of dental CAD/CAM ceramics of variable thicknesses and structures: an in vitro study.","authors":"Passent Ellakany, Yousif A Al-Dulaijan, Nourhan M Aly, Turki Alshehri, Shahad T Alameer, Sultan Akhtar, Laila Al Dehailan","doi":"10.12688/f1000research.157128.3","DOIUrl":"10.12688/f1000research.157128.3","url":null,"abstract":"<p><strong>Background: </strong>This study examined the effect of thermocycling on the flexural strength properties of four CAD/CAM ceramic materials at different thicknesses.</p><p><strong>Methods: </strong>Four CAD/CAM ceramics of different types: advanced lithium disilicate (ALD), zirconia-reinforced lithium silicate (ZLS) lithium disilicate (LD), and leucite reinforced (LE), and at three varying thicknesses 0.5, 1.0 and 1.5 mm were examined. After subjecting all specimens to 5000 thermal cycles, flexural strength was determined using a universal testing apparatus. Scanning electron microscopy (SEM) was employed for analysis. Two factorial ANOVA models assessed the association of different factors (ceramic type and thickness) with flexural strength and elastic modulus. The 95% confidence intervals (CIs) and adjusted means were computed. A p-value < 0.05 was designated significant.</p><p><strong>Results: </strong>ZLS exhibited the highest flexural strength at 1.5 mm thickness, while LD showed the highest Young's modulus of elasticity. The lowest flexural strength was observed in the 0.5 mm thickness group of all tested groups. There were notable variations in flexural strength across all ceramic materials, with the highest adjusted mean strength in the ZLS group, ALD, LD, and LE, respectively. Additionally, significant differences were noted in ceramic thickness, with 1.5 mm thickness showing the highest strength and 0.5 mm thickness the lowest.</p><p><strong>Conclusions: </strong>Ceramic material thickness significantly impacts flexural strength, with 1.5 mm thickness deemed suitable for posterior restorations. Ceramic materials with zirconia fillers or matrix demonstrated higher flexural strength than other ceramics.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1310"},"PeriodicalIF":0.0,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12322662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144788578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"It's messy and it's massive\": How has the open science debate developed in the post-COVID era?","authors":"Melanie T Benson Marshall, Stephen Pinfield, Pamela Abbott, Andrew Cox, Juan Pablo Alperin, Natascha Chtena, Alice Fleerackers","doi":"10.12688/f1000research.162577.2","DOIUrl":"10.12688/f1000research.162577.2","url":null,"abstract":"<p><p>The COVID-19 pandemic accelerated the global adoption of open science (OS) practices. However, as the pandemic subsides, the debate around OS continues to evolve. This study investigates how the pandemic has shaped the OS discourse and identifies key issues and challenges. Interviews were conducted with influential actors across the research and publishing communities. The findings show that while many areas of debate remained constant, the ways in which they were discussed exposed underlying systemic challenges, which must be addressed if OS is to progress. These issues included the scope and definition of OS; regional variations in its implementation; the relationship between OS and fundamental questions of the purpose and practice of science; and the need to reform incentives and reward structures within research systems. A more complex understanding of OS is required, which takes into account the importance of equity and diversity and the challenges of implementing OS in different cultural and geographical contexts. The study emphasises the importance of shifting scientific culture to prioritise values such as quality, integrity, and openness, and reforming rewards structures to incentivise open practices.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"500"},"PeriodicalIF":0.0,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional opal mining practice in Ethiopia, challenges and its economic impact on rural households: the case of wollo opal mining.","authors":"Tadesse Wudu Abate, Addise Zemelak Sisay","doi":"10.12688/f1000research.156436.3","DOIUrl":"10.12688/f1000research.156436.3","url":null,"abstract":"<p><strong>Background: </strong>The discovery spurred further exploration, leading to the expansion of opal mining into neighboring districts. Numerous cooperative groups, composed of small-scale miners, traditionally explore, develop, and extract significant amounts of rough opal gemstones. This study tries to investigate the challenges and economic impacts of traditional opal mining practice in wollo province of Ethiopia.</p><p><strong>Methods: </strong>The study used in this study is primary data collected from rural households, which are living in five districts of north wollo zone, in Amhara regional state. The data was collected using field observation, focus grouped discussion, interview, and questionnaire from sampled households. The study uses both descriptive and econometric methods of data analysis to achieve its objective.</p><p><strong>Results: </strong>Among the challenges of traditional opal mining, primitive way of exploring and extraction, limited access to market and low institutional support in terms of training and finance are identified. The probit model reveals that, increased education, access to training, and access to credit positively influence the likelihood of engaging in opal mining. The ESR model shows that, the average treatment effect on the treated (ATT) indicates that participating in Participation in opal mining is associated with higher monthly income by 31,380 ETB, while the average treatment effect on the untreated (ATU) shows a potential income increase of 31,625 ETB for non-miners if they engaged in mining.</p><p><strong>Conclusion: </strong>The study identifies three main categories of challenges faced by traditional opal miners: exploration and extraction issues, market limitations, and regulatory and institutional shortcomings. Exploration and extraction challenges include the lack of modern mining tools and knowledge, as well as difficult terrain, leading to inefficient and hazardous mining practices. Market-related challenges involve limited access to broader markets and lack of value addition, resulting in miners selling raw opals at significantly lower prices compared to polished ones.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1388"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12290443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144729063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ozone water or chloroxylenol: The comparison of disinfection effectiveness against the number of bacterial colonies in dental extraction instruments at the Universitas Sumatera Utara Dental and Oral Hospital.","authors":"Hendry Rusdy, Rahmi Syaflida Dalimunthe, Ahyar Riza, Ismahani Akilah D","doi":"10.12688/f1000research.132941.4","DOIUrl":"https://doi.org/10.12688/f1000research.132941.4","url":null,"abstract":"<p><strong>Background: </strong>The application of disinfectants on dental instruments is one way to prevent cross-infection. The urgency in this research is ozone water as a disinfectant is still limited and no research has been found on the use of ozone water on tooth extraction instruments. However, ozone has antibacterial properties so researchers are interested in studying the effectiveness of ozone water as a disinfectant when compared to the commonly used 4.8% chloroxylenol. This study aimed to determine the effectiveness of disinfection of ozone water and 4.8% chloroxylenol in reducing the number of bacterial colonies on dental extraction instruments at the Universitas Sumatera Utara Dental and Oral Hospital.</p><p><strong>Methods: </strong>The samples used were mandibular molar forceps have been used in tooth extraction procedures. This study was experimental and used 30 sample, where each group consisted of 10 tooth extraction instruments. The treatment group used ozone water and 4.8% chloroxylenol and the negative control group was cleaned with distilled water. The ozone water group was produced with an ozone generator with a concentration of 15 mg/L for 20 minutes. Then the active side of tooth extraction forceps was soaked for 30 minutes. In the 4.8% chloroxylenol (dettol®) group, the active side of the mandibular molar tooth extraction forceps was soaked in 250 mL for 60 minutes. In the control group, the mandibular molar tooth extraction forceps were rinsed with distilled water. After that, the sample was counted using a bactery colony counter.</p><p><strong>Results: </strong>The results of the data analysis showed a p-value ≤0.001, which means there was a significant difference in the disinfection using ozone water and 4.8% chloroxylenol on the number of bacterial colonies on dental extraction instruments.</p><p><strong>Conclusions: </strong>From this study it can be said that ozone water is more effective in disinfecting than 4.8% chloroxylenol.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"12 ","pages":"726"},"PeriodicalIF":0.0,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12374152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}