F1000ResearchPub Date : 2025-05-01eCollection Date: 2025-01-01DOI: 10.12688/f1000research.160297.2
Arvind Nain, N S Bohra, Archana Singh, Rekha Verma, Rakesh Kumar, Rajesh Kumar
{"title":"Mapping the landscape: A bibliometric analysis of AI and teacher collaboration in educational research.","authors":"Arvind Nain, N S Bohra, Archana Singh, Rekha Verma, Rakesh Kumar, Rajesh Kumar","doi":"10.12688/f1000research.160297.2","DOIUrl":"10.12688/f1000research.160297.2","url":null,"abstract":"<p><strong>Background: </strong>This study intends to investigate the relationship between artificial intelligence and teachers' collaboration in educational research in response to the growing use of technologies and the current status of the field.</p><p><strong>Methods: </strong>A total of 62 publications were looked at through a systematic review that included data mining, analytics, and bibliometric methods.</p><p><strong>Result: </strong>The study shows a steady increase in the field of artificial intelligence and teacher collaboration in educational research, especially in the last few years with the involvement of the USA, China, and India. Education and information technology are the main contributors to this field of study, followed by an international review of open and distance learning research. The Scopus database was chosen for this study because of its extensive coverage of high-quality, peer-reviewed literature and robust indexing system, making it a dependable source for conducting bibliometric analyses. Scopus offers substantial information, citations tracking, and multidisciplinary coverage, which are critical for spotting publication trends, significant articles, major themes, and keywords in the area. The findings show that education and information technology make the most significant contributions to this sector, followed by international studies on open and distance learning.</p><p><strong>Conclusions: </strong>Over a three-year period, the average citation value is 12.44%. The education system, learning, e-learning, sustainability, COVID-19 issues, team challenges, organizational conflicts, and digital transformation are just a few of the topics it significantly contributes to. The study acknowledges its limitations and considers potential avenues for additional research. The results also emphasize important gaps in the literature, highlighting the necessity for more research. This information can help develop strategic approaches to address issues and take advantage of opportunities relating to artificial intelligence and teacher collaboration in higher education and research. The study's ultimate goal is to offer guidance for tactics that promote teachers' cooperation in educational research and the development of artificial intelligence.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"201"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F1000ResearchPub Date : 2025-04-28eCollection Date: 2025-01-01DOI: 10.12688/f1000research.163914.1
Layal Rabih, Elie Yammine
{"title":"E-learning success evaluation in Lebanon during wartime: An extension of Delone and McLean IS success model.","authors":"Layal Rabih, Elie Yammine","doi":"10.12688/f1000research.163914.1","DOIUrl":"10.12688/f1000research.163914.1","url":null,"abstract":"<p><strong>Background: </strong>In the fast-paced digital world, e-learning has become the most convenient medium for higher education institutions to provide scalable education. It is used to provide a flexible educational process through the employment of new technologies. Due to the impact of the war on education in Lebanon during fall 2024-2025 and the suspension of traditional learning, e-learning adoption was the answer to the ministry of education and higher education call for learning continuity. Despite extensive research on e-learning systems, limited empirical evidence exists on factors affecting its success during wartime. This study aims to assesses this success in achieving learning outcomes within the context of higher education under war risks based on the Delone and McLean IS model [1].</p><p><strong>Methods: </strong>A quantitative approach was employed using a structured questionnaire distributed to 429 students and academic staff within higher education institutions in Lebanon. Sampling and data analysis were conducted through structural equation modelling to test hypothesized relationships of the proposed model in SPSS 27.0 using the path analysis.</p><p><strong>Results: </strong>The goodness-of-fit measurement of the model represent the desirability and good fit of the model (SRMR = 0. 048). The Cronbach's α values varying between 0.765 and 0.944, and CR values varying between 0.753, and 0.954, were considered sufficiently error-free and demonstrated the model's internal consistency and the constructs' good reliability. The AVE values ranging from 0.509 to 0.808 were all valid, and their convergent validity was fulfilled. The HTMT and the confidence interval empirical criterions are met and constructs discriminant validity is certain. The R <sup>2</sup>, β, and Q <sup>2</sup> measures showed which constructs have strong or weak relationships strength, and large or small predictive relevance.</p><p><strong>Conclusions: </strong>According to empirical results, findings reveal that war-perceived risk directly and indirectly affects all model dimensions. Service quality does not significantly affect the intention to use/use, or user satisfaction. Moreover, intention to use/use had no significant impact on the success of e-learning in terms of satisfying its users and attaining their expected learning outcomes. Thus, the war risks imposes the e-learning usage to achieve its outcomes as the only available solution for learning in such circumstances.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"468"},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F1000ResearchPub Date : 2025-04-28eCollection Date: 2024-01-01DOI: 10.12688/f1000research.157435.2
Zulfikar Bagus Pambuko, Jaka Sriyana, Akhsyim Affandi, Abdul Hakim
{"title":"Influence of spin-off decision on financing risk: Empirical insight from Indonesian Islamic banks.","authors":"Zulfikar Bagus Pambuko, Jaka Sriyana, Akhsyim Affandi, Abdul Hakim","doi":"10.12688/f1000research.157435.2","DOIUrl":"https://doi.org/10.12688/f1000research.157435.2","url":null,"abstract":"<p><strong>Background: </strong>Spin-offs play a significant role in organizational development strategies, particularly in Islamic banking, by fostering entrepreneurship, innovation, and Shariah-compliant management practices. Indonesia stands as a pioneer in implementing the dual banking system and has established a spin-off policy to foster the growth of Islamic banking. This study investigates whether the spin-off decision has a significant impact on financing risk in Indonesian Islamic banks.</p><p><strong>Methods: </strong>Financing risk is measured by the non-performing financing ratio, while the spin-off decision is represented by a dummy variable equal to 1 for the post-spin-off period and 0 for the pre-spin-off period. This study utilizes data from semi-annual reports of 35 Indonesian Islamic banks and analyzes it using a dynamic panel model with the Generalized Method of Moments (GMM) to overcome potential endogeneity issues that might bias the results.</p><p><strong>Results: </strong>The findings reveal that spin-offs significantly reduce financing risk, thereby enhancing the financial resilience and boosting investor appeal. Notably, this implies that Islamic banks operating as Islamic windows exhibit a higher level of financing risk compared to fully-fledged Islamic banks. Furthermore, a noteworthy pattern emerges that spin-off Islamic banks with substantial assets demonstrate greater risk in comparison to their counterparts with more modest assets. System GMM also confirmed the result.</p><p><strong>Conclusions: </strong>Islamic banks can significantly reduce their financing risks by establishing independent Islamic banks, or spin-offs. Unlike Islamic windows, which are typically integrated within conventional banks and face higher risk levels, standalone Islamic banks offer greater flexibility and control over their operations. Therefore, spin-off policies for Islamic banks appear to be a viable strategy, as independence fosters enhanced risk sensitivity.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1251"},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11993850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Associations Between Factors Affecting Itching and Quality of Life in Thai Patients with Psoriasis: A Cross-Sectional Study.","authors":"Phurichaya Teyateeti, Chanita Autchayawat, Wiriya Mahikul, Rithee Smithrithee","doi":"10.12688/f1000research.156703.2","DOIUrl":"10.12688/f1000research.156703.2","url":null,"abstract":"<p><strong>Introduction: </strong>Psoriasis is a chronic skin disease affecting quality of life and causing pruritus. The factors influencing itch and its impact on the quality of life in Thai psoriasis patients are unknown. We aimed to identify these factors and their effect on quality of life.</p><p><strong>Methods: </strong>In this questionnaire-based cross-sectional study, we included patients with psoriasis who received treatment at Chulabhorn Hospital in Thailand from January 2019 to July 2021. Interviewer is the non-dermatologist practician. The patient's information was collected, including demographic data, Itch Numeric Rating Scale (Itch NRS) score, factors affecting itch, and score on the Thai version of the Dermatology Life Quality Index (DLQI). We performed descriptive statistics and logistic regression analysis.</p><p><strong>Results: </strong>Of 100 participants, most (99%) experienced itching, with a moderate degree of pruritus (mean Itch NRS score 6.5 ± 2.6) and a moderate effect on quality of life (mean DLQI score 9.4 ± 6.2). Factors associated with itch aggravation were dry skin (p-value = 0.003) and heat and humidity (p-value = 0.042). The results of binary logistic regression revealed that factors associated with moderate-to-extremely large DLQI scores were itch intensity (no-to-mild vs. moderate-to-severe itch: odds ratio [OR] = 13.33; 95% confidence interval [CI] = 2.72-65.32, <i>p</i> < 0.001; and adjusted odds ratio [AOR] = 31.17; 95% CI = 4.55-213.36; <i>p</i> < 0.001.</p><p><strong>Conclusions: </strong>Our findings revealed that the quality of life among patients with psoriasis is their greatest concern. Eliminating the itch intensity that affects their quality of life is crucial but remains challenging in Thailand.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1242"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Case Report: A new modification of Loma Linda pouch technique.","authors":"Hazem Redwan, Munir Harfouch, Abdulkarim Sheikh Ibrahim, Ali Silan, Issam Alkhouri","doi":"10.12688/f1000research.160451.2","DOIUrl":"10.12688/f1000research.160451.2","url":null,"abstract":"<p><p>Dental implants provide a reliable treatment option for completely or partially edentulous patients. In case of a membrane perforation, the gap can be closed using a piece of resorbable collagen membrane or by suturing the Schneiderian membrane using a resorbable suture. The present study shows a new development in this technique, which involves modifying the design of the absorbable membrane and using pins to fix the membrane. This study concluded that the novel design of the collagen membrane and its fixation with the pins led to greater stability of the bone graft and led to subsequent bone gain that enables dental implantation. Still, this technique requires a histological study to determine the nature of the bone formed.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"383"},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F1000ResearchPub Date : 2025-04-24eCollection Date: 2025-01-01DOI: 10.12688/f1000research.161261.1
Edgar López-López, Ana Margarita Hernández-Segura, Carlos Lara-Cuellar, Carolina Barrientos-Salcedo, Carlos M Cerda-García-Rojas, José L Medina-Franco
{"title":"Nat-UV DB: A Natural Products Database Underlying of Veracruz-Mexico.","authors":"Edgar López-López, Ana Margarita Hernández-Segura, Carlos Lara-Cuellar, Carolina Barrientos-Salcedo, Carlos M Cerda-García-Rojas, José L Medina-Franco","doi":"10.12688/f1000research.161261.1","DOIUrl":"10.12688/f1000research.161261.1","url":null,"abstract":"<p><strong>Background: </strong>Natural products databases are well-structured data sources that offer new molecular development opportunities in drug discovery, agrochemistry, food, cosmetics, and several other research disciplines or chemical industries. The crescent world's interest in the development of these databases is related to the exploration of chemical diversity in geographical regions with rich biodiversity.</p><p><strong>Methods: </strong>In this work, we introduce and discuss Nat-UV DB, the first natural products database from a coastal zone of Mexico. We discuss its construction, curation, and chemoinformatic characterization of their content, and chemical space coverage compared with other compound databases, like approved drugs, and other Mexican (BIOFACQUIM and UNIIQUIM databases) and the Latin American natural products database (LaNAPDB).</p><p><strong>Results: </strong>Nat-UV DB comprises 227 compounds that contain 112 scaffolds, of which 52 are not present in previous natural product databases. The compounds present in Nat-UV DB have a similar size, flexibility, and polarity to previously reported natural products and approved drug datasets.</p><p><strong>Conclusions: </strong>Nat-UV DB compounds have a higher structural and scaffold diversity than the approved drugs, but they have low structural and scaffold diversity in contrast with other natural products in the reference datasets. This database serves as a valuable addition to the global natural products landscape, bridging gaps in exploring biodiversity-rich regions.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F1000ResearchPub Date : 2025-04-23eCollection Date: 2022-01-01DOI: 10.12688/f1000research.109236.2
Mauro Petrillo, Maddalena Querci, Carlo Brogna, Jessica Ponti, Simone Cristoni, Peter V Markov, Andrea Valsesia, Gabriele Leoni, Alessandro Benedetti, Thierry Wiss, Guy Van den Eede
{"title":"Evidence of SARS-CoV-2 bacteriophage potential in human gut microbiota.","authors":"Mauro Petrillo, Maddalena Querci, Carlo Brogna, Jessica Ponti, Simone Cristoni, Peter V Markov, Andrea Valsesia, Gabriele Leoni, Alessandro Benedetti, Thierry Wiss, Guy Van den Eede","doi":"10.12688/f1000research.109236.2","DOIUrl":"10.12688/f1000research.109236.2","url":null,"abstract":"<p><strong>Background: </strong>In previous studies we have shown that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates <i>in vitro</i> in bacterial growth medium, that the viral replication follows bacterial growth, and it is influenced by the administration of specific antibiotics. These observations are compatible with a 'bacteriophage-like' behaviour of SARS-CoV-2.</p><p><strong>Methods: </strong>We have further elaborated on these unusual findings and here we present the results of three different supplementary experiments: (1) an electron-microscope analysis of samples of bacteria obtained from a faecal sample of a subject positive to SARS-CoV-2; (2) mass spectrometric analysis of these cultures to assess the eventual de novo synthesis of SARS-CoV-2 spike protein; (3) sequencing of SARS-CoV-2 collected from plaques obtained from two different gut microbial bacteria inoculated with supernatant from faecal microbiota of an individual positive to SARS-CoV-2.</p><p><strong>Results: </strong>Immuno-labelling with Anti-SARS-CoV-2 nucleocapsid protein antibody confirmed presence of SARS-CoV-2 both outside and inside bacteria. <i>De novo</i> synthesis of SARS-CoV-2 spike protein was observed, as evidence that SARS-CoV-2 RNA is translated in the bacterial cultures. In addition, phage-like plaques were spotted on faecal bacteria cultures after inoculation with supernatant from faecal microbiota of an individual positive to SARS-CoV-2. Bioinformatic analyses on the reads obtained by sequencing RNA extracted from the plaques revealed nucleic acid polymorphisms, suggesting different replication environment in the two bacterial cultures.</p><p><strong>Conclusions: </strong>Based on these results we conclude that, in addition to its well-documented interactions with eukaryotic cells, SARS-CoV-2 may act as a bacteriophage when interacting with at least two bacterial species known to be present in the human microbiota. If the hypothesis proposed, i.e., that under certain conditions SARS-CoV-2 may multiply at the expense of human gut bacteria, is further substantiated, it would drastically change the model of acting and infecting of SARS-CoV-2, and most likely that of other human pathogenic viruses.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"11 ","pages":"292"},"PeriodicalIF":0.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F1000ResearchPub Date : 2025-04-22eCollection Date: 2021-01-01DOI: 10.12688/f1000research.52288.3
Ek-Uma Imkome
{"title":"Psychometric Evaluation of the Thai Version of the Burdened Caregiver Scale for Schizophrenia and Co-occurring Methamphetamine Use: A Pilot Study.","authors":"Ek-Uma Imkome","doi":"10.12688/f1000research.52288.3","DOIUrl":"10.12688/f1000research.52288.3","url":null,"abstract":"<p><strong>Objective: </strong>To develop and test the psychometric properties of the Thai version of the Impact and Burden of Care Scale for Caregivers of Persons with Schizophrenia and Co-occurring Methamphetamine Use (TIBSCSM).</p><p><strong>Methods: </strong>This pilot study involved 142 caregivers of individuals with schizophrenia and methamphetamine use. Sample adequacy was assessed using the Kaiser-Meyer-Olkin (KMO) method, while Bartlett's test evaluated the item correlation matrix. Exploratory factor analysis (EFA) was conducted to identify underlying factors.</p><p><strong>Results: </strong>The 32-item TIBSCSM showed convergent validity correlations with two quality-of-life measures. The KMO value was 0.90, and Bartlett's Test of Sphericity yielded χ <sup>2</sup> = 5248.5, df = 496, p < 0.001. The Content Validity Index (CVI) was 1, indicating high internal consistency reliability (α = 0.90). EFA identified four constructs: physical function, self-esteem, role and social enjoyment, and relationship satisfaction. The model exhibited strong reliability and validity, with an average variance extracted (AVE) of 0.948 and composite reliability (CR) of 0.987, accounting for 64.90% of the variance.</p><p><strong>Conclusion: </strong>The TIBSCSM scale provides valuable insights for psychiatric nurses and mental health teams to measure the impact and burden experienced by caregivers of individuals with schizophrenia and methamphetamine use. It is particularly useful for nursing, research, education, and clinical practice, especially in addressing the caregiver burdens exacerbated during the COVID-19 pandemic.</p><p><strong>Implication for nursing and research: </strong>The TIBSCSM, developed in the Thai context, can facilitate studies evaluating variations in caregiver impact across different settings.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"10 ","pages":"484"},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F1000ResearchPub Date : 2025-04-22eCollection Date: 2025-01-01DOI: 10.12688/f1000research.163722.1
Deenadayal Devarajan, Manjusha Rajagopala
{"title":"Neuroprotective Activity of Rasayana Formulation and Effect of Shigru Pallava Eye Drops on Intraocular Pressure as an Add-on Therapy Compared to the Standard of Care in Primary Open-Angle Glaucoma: Protocol for an Exploratory, Open-label, Two-arm Randomized Controlled Trial.","authors":"Deenadayal Devarajan, Manjusha Rajagopala","doi":"10.12688/f1000research.163722.1","DOIUrl":"10.12688/f1000research.163722.1","url":null,"abstract":"<p><strong>Background: </strong>Primary open-angle glaucoma (POAG) is a major cause of irreversible blindness worldwide, characterized by progressive optic neuropathy and loss of retinal ganglion cells (RGCs). Although lowering intraocular pressure (IOP) remains the mainstay of glaucoma management, many patients continue to experience vision loss, underscoring the need for adjunctive neuroprotective approaches. In Ayurveda, <i>Rasayana</i> therapies are believed to slow degenerative processes. One such intervention is a Rasayana Formulation (RF) comprising three oral preparations; Rasayana Churna (RC), Saptamrita Lauha (SL), and Yashada Bhasma (YB). Additionally, topical Arka (distilled extract) of Shigru Pallava (SP) has been used traditionally for glaucoma and may have an IOP-lowering effect.</p><p><strong>Methods: </strong>This is an open-label, two-arm, parallel-group randomized controlled trial with a 2:3 (control: intervention) allocation ratio. A total of 50 previously or newly diagnosed POAG patients (IOP < 30 mmHg) are planned for enrollment. The control group receives the conventional standard of care alone, whereas the intervention group receives standard care plus RF (2.5 g, taken orally twice daily) and SP eye drops (1 drop, four times daily), administered for 90 days with a further 90-day follow-up. Primary outcomes include changes in optic nerve function measured by visual field indices (mean deviation (MD), pattern standard deviation (PSD), visual field index (VFI)) and retinal nerve fiber layer (RNFL) thickness, while secondary outcomes include IOP changes.</p><p><strong>Results: </strong>Participant recruitment and data collection are ongoing. Final outcomes will be disseminated in peer-reviewed journals.</p><p><strong>Conclusions: </strong>If shown to be effective, the combined RF and SP eye drops could enhance neuroprotection and further control IOP in POAG, thereby addressing a significant need in current glaucoma therapy. This trial may provide a foundation for larger-scale investigations into integrative treatments for glaucoma management.</p><p><strong>Trial registration: </strong>Clinical Trial Registry of India (CTRI) no. CTRI/2023/06/053681, dated 08.06.2023.Available from: https://trialsearch.who.int/Trial2.aspx?TrialID=CTRI/2023/06/053681 <b>Protocol Version:</b> 3.0, dated 05.01.2023.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"454"},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F1000ResearchPub Date : 2025-04-22eCollection Date: 2022-01-01DOI: 10.12688/f1000research.122560.2
Farapti Farapti, Putri Hersya Maulia, Chusnul Fadilla, Niwanda Yogiswara, Purwo Sri Rejeki, Muhammad Miftahussurur, Hazreen Abdul Majid
{"title":"Community-level dietary intake of sodium, potassium, and sodium-to-potassium ratio as a global public health problem: a systematic review and meta-analysis.","authors":"Farapti Farapti, Putri Hersya Maulia, Chusnul Fadilla, Niwanda Yogiswara, Purwo Sri Rejeki, Muhammad Miftahussurur, Hazreen Abdul Majid","doi":"10.12688/f1000research.122560.2","DOIUrl":"10.12688/f1000research.122560.2","url":null,"abstract":"<p><strong>Background: </strong>Widespread adoption of a westernized diet represents a major lifestyle change characterized by substantially higher sodium consumption and lower potassium intake, which is related to cardiovascular morbidity.</p><p><strong>Methods: </strong>We performed a systematic review and meta-analysis over published studies in accordance with quantifying the dietary intake of sodium and potassium of the universal population across the world. The PubMed, EMBASE, Cochrane Library, and Google Scholar databases were used to find research that pronounced 24-hour urinary sodium or potassium excretion (reference period: 2014-2021). The effect size was estimated using the fixed-effect model; sub-group analysis become accomplished to determine urinary sodium and potassium excretion disaggregated by geographical location. Publication bias became evaluated the usage of graphical funnel plot. Data analysis was performed using STATA 16.</p><p><strong>Results: </strong>Forty-three studies (n= 62,940) qualified the selection criteria. The mean urinary excretion of sodium and potassium was 156.73 mmol/24h [95% confidence interval (CI), 148.98-164.47] and 48.89 mmol/24 h (95% CI, 43.61-54.17), respectively; the mean urinary sodium/potassium ratio was 3.68 (95% CI, 2.96-4.40).</p><p><strong>Conclusions: </strong>This updated systematic review highlights excessively high dietary intake of sodium and low intake of potassium at the community level in most parts of the world. The urinary Na/K ratio exceeded the level recommended by the WHO guidelines.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"11 ","pages":"953"},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}