F1000Research最新文献

{"title":"Analyzing Molecular Traits of H9N2 Avian Influenza Virus Isolated from a Same Poultry Farm in West Java Province, Indonesia, in 2017 and 2023.","authors":"Muhammad Ade Putra, Amin Soebandrio, I Wayan Teguh Wibawan, Christian Marco Hadi Nugroho Nugroho, Ryan Septa Kurnia, Otto Sahat Martua Silaen, Rifky Rizkiantino, Agustin Indrawati, Okti Nadia Poetri, Desak Gede Budi Krisnamurti","doi":"10.12688/f1000research.150975.2","DOIUrl":"10.12688/f1000research.150975.2","url":null,"abstract":"<p><strong>Background: </strong>Indonesia is one of the countries that is endemic to avian influenza virus subtype H9N2. This study aims to compare the molecular characteristics of avian influenza virus (AIV) subtype H9N2 from West Java.</p><p><strong>Methods: </strong>Specific pathogen-free (SPF) embryonated chicken eggs were used to inoculate samples. RNA extraction and RT-qPCR confirmed the presence of H9 and N2 genes in the samples. RT-PCR was employed to amplify the H9N2-positive sample. Nucleotide sequences were obtained through Sanger sequencing and analyzed using MEGA 7. Homology comparison and phylogenetic tree analysis, utilizing the neighbor-joining tree method, assessed the recent isolate's similarity to reference isolates from GenBank. Molecular docking analysis was performed on the HA1 protein of the recent isolate and the A/Layer/Indonesia/WestJava-04/2017 isolate, comparing their interactions with the sialic acids Neu5Ac2-3Gal and Neu5Ac2-6Gal.</p><p><strong>Results: </strong>RT-qPCR confirmed the isolate samples as AIV subtype H9N2. The recent virus exhibited 11 amino acid residue differences compared to the A/Layer/Indonesia/WestJava-04/2017 isolate. Phylogenetically, the recent virus remains within the h9.4.2.5 subclade. Notably, at antigenic site II, the recent isolate featured an amino acid N at position 183, unlike A/Layer/Indonesia/WestJava-04/2017. Molecular docking analysis revealed a preference of HA1 from the 2017 virus for Neu5Ac2-3Gal, while the 2023 virus displayed a tendency to predominantly bind with Neu5Ac2-6Gal.</p><p><strong>Conclusion: </strong>In summary, the recent isolate displayed multiple mutations and a strong affinity for Neu5Ac2-6Gal, commonly found in mammals.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"571"},"PeriodicalIF":0.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11602698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Teaching Self-efficacy and Teaching Methods in the Aquatic Environment.","authors":"Rita Fonseca-Pinto, Juan Antonio Moreno-Murcia","doi":"10.12688/f1000research.150535.2","DOIUrl":"10.12688/f1000research.150535.2","url":null,"abstract":"<p><strong>Background: </strong>Studies have shown that perceived self-efficacy can influence teachers' emotional state, thoughts and behaviours, and students' learning. It's also an important referential of professional satisfaction. Teaching theories influence learning, human development, motivation levels and, consequently, continuity of practice in favour of healthy lifestyle. Research on aquatic educators and teaching theories is both limited and essential, as aquatic literacy is considered a vital component of physical literacy, enabling individuals to better interact with aquatic environments.</p><p><strong>Methods: </strong>For this study we used an online questionnaire, aimed at aquatic educators, which was answered voluntarily and anonymously to 1) assess the professionals' perception of self-efficacy; 2) which teaching theories are most used by aquatic educators and 3) identify the teaching theory used by professionals who perceive themselves as most effective. It has been deposited and can be consulted at https://doi.org/10.6084/m9.figshare.27316242.v1.</p><p><strong>Results: </strong>All teaching theories can generate a feeling of self-efficacy in teachers despite having different results, with the theories that involve students more actively (cognitivist and constructivist) being those that generate a greater feeling of self-efficacy in teachers. Comprehensive Aquatic Method (MAC) is a method that is more closely related to theories focused on active student participation and, consequently, it is a theory that generates a high perception of self-efficacy in teachers.</p><p><strong>Conclusions: </strong>Levels of self-efficacy influence aquatic educators satisfaction, educator physical, mental and emotional health, as well as student learning. Is recommended that aquatic educators give prevalence to the cognitivist and constructivist teaching theories being MAC a privileged methodology approach for promoting active lifestyle habits throughout life.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1363"},"PeriodicalIF":0.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11904400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel gastrointestinal tools (GI Tools) for evaluating gut functional capacity in adults with environmental enteropathy in Zambia and Zimbabwe: A cross-sectional study protocol.","authors":"Tracy N Phiri, James W Weatherill, Elena Monford-Sanchez, Jose-Ivan Serrano-Contreras, Callum Melvin, Mirriam Kunaka, Ian Chisenga, Perpetual Ngalande, Monica N Mweetwa, Ellen Besa, Tafhima Haider, Nilanjan Mandal, Alex J Thompson, Christine A Edwards, Claire D Bourke, Ruairi C Robertson, Joram M Posma, Rosemary Banda, Mulima Mwiinga, Lydia Kazhila, Leolin Katsidzira, Mutsa Bwakura-Dangarembizi, Beatrice Amadi, Isabel Garcia-Perez, Kathryn Maitland, Julian R Marchesi, Douglas J Morrison, Gary Frost, Paul Kelly","doi":"10.12688/f1000research.154471.2","DOIUrl":"10.12688/f1000research.154471.2","url":null,"abstract":"<p><strong>Background: </strong>Environmental enteropathy (EE) is a highly prevalent subclinical inflammatory intestinal disorder associated with growth failure, impaired neurocognitive development, poor response to oral vaccines, and micronutrient deficiencies. However, EE research and clinical trials are hampered by the lack of non-invasive tools for measuring intestinal function in detail. This study aims to develop new tools for the measurement of multiple domains of gut functional capacity.</p><p><strong>Methods: </strong>The GI TOOLS project is a cross-sectional study that will recruit adults aged 18-65 years with EE in Lusaka, Zambia. Each participant will undergo assessment of gut functional capacity using novel near-point-of-care tools and provide multiple samples for detailed laboratory analyses. Participants will also undergo endoscopy for collection of duodenal biopsies. Novel techniques include stable isotopes approaches to measuring digestion, absorption, and bidirectional transmucosal amino acid flux, a non-invasive fluorescence tool for real-time evaluation of gut permeability, and assessment of reverse permeation of intravenous antibiotics to be carried out separately in Zimbabwe. Stool and duodenal microbiome sequencing using MinION sequencing, metabolome analysis applied to plasma and intestinal fluids, blood immune cell phenotyping, <i>in vitro</i> epithelial barrier models, and duodenal immunohistochemistry will also be used to explore EE in depth. These will all be integrated with gold standard histology and mucosal morphometry, alongside lactulose permeation data, and stool and plasma biomarker analysis. The protocol has been approved by ethics committees and regulators in Zambia, Zimbabwe, and the UK. Participants will give informed consent before they can participate.</p><p><strong>Anticipated outcomes: </strong>Based on this extensive phenotyping, tests will be developed which can be simplified and refined for use in adults and children with EE, and for clinical trials. Findings from this project will be disseminated through in-person meetings with caregivers and regulatory bodies, presentations at conferences and in peer-reviewed journals.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"956"},"PeriodicalIF":0.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with death in patients admitted with Ebola virus disease to Ebola Treatment Units in Guinea, Sierra Leone, and Liberia - December 2013 to March 2016.","authors":"Trokon Omarley Yeabah, Ibrahima Kaba, Gomathi Ramaswamy, Prabin Dahal, Alexandre Delamou, Benjamin T Vonhm, Ralph W Jetoh, Laura Merson, Adam C Levine, Pryanka Relan, Anthony D Harries, Ajay M V Kumar","doi":"10.12688/f1000research.149612.2","DOIUrl":"10.12688/f1000research.149612.2","url":null,"abstract":"<p><strong>Background: </strong>The 2013-2016 West African Ebola Virus Disease (EVD) outbreak resulted in 28,600 cases and 11,300 deaths officially reported to the World Health Organization. Previous studies investigating factors associated with death had conflicting findings, interventions showing promising outcomes had small sample sizes, studies were often single- or dual-country based and most focused on laboratory-confirmed EVD and not on clinically-suspected EVD. We used the Ebola data platform of the Infectious Disease Data Observatory (IDDO) to review individual patient records to assess factors associated with death, and particularly whether there were differences between laboratory-confirmed and clinically-suspected cases.</p><p><strong>Methods: </strong>This was a cohort study involving analysis of secondary data in the IDDO database. The study population included all patients classified as having either clinically-suspected or laboratory-confirmed EVD, admitted to 22 Ebola Treatment Units (ETU) in Guinea, Liberia and Sierra Leone between December 2013 and March 2016. Baseline characteristics and treatments were documented along with ETU exit outcomes. Factors associated with death were investigated by multivariable modified Poisson regression.</p><p><strong>Results: </strong>There were 14,163 patients, of whom 6,208 (43.8%) were laboratory-confirmed and 7,955 (56.2%) were clinically-suspected. Outcomes were not recorded in 2,889 (20.4%) patients. Of the 11,274 patients with known outcomes, 4,090 (36.3%) died: 2,956 (43.6%) with laboratory-confirmed EVD and 1,134 (18.8%) with clinically-suspected EVD. The strongest risk factor for death was confirmed disease status. Patients with laboratory-confirmed disease had 2.9 times higher risk of death compared to clinically-suspected patients, after adjusting for other co-variables. Other factors significantly associated with death included a higher risk for patients aged ≥60 years and a lower risk for patients in Sierra Leone.</p><p><strong>Conclusions: </strong>Although laboratory-confirmed patients admitted to ETUs fared worse than clinically-suspected patients, the latter still had a substantial risk of death and more attention needs to be paid to this group in future EVD outbreaks.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"672"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is relief the most common reaction to abortion? Self-assessed intensity of emotions attributed to abortion in a national sample of women aged 41 to 45.","authors":"David Reardon","doi":"10.12688/f1000research.162063.1","DOIUrl":"10.12688/f1000research.162063.1","url":null,"abstract":"<p><strong>Background: </strong>It is widely reported that the most prominent emotion following abortions is relief. This claim primarily rests on two studies of abortion clinic patients which had methodological and self-censure bias. Other studies have indicated that negative emotions are more common than positive emotions. The objective of this study is to obtain self-assessed data on the intensity of emotional responses to abortion and pregnancy loss in a random national sample.</p><p><strong>Methods: </strong>Using visual analog scales, a random sample of 1,925 women aged 41 to 45 completed a survey in which respondents rated the degree to which they experienced emotional responses to their first abortion or natural pregnancy loss. The emotions assessed included relief, grief, depression, anxiety, guilt, emptiness, anger, regret, shame, unforgiveness of self, uncontrollable weeping, frequent thoughts of the child they could have had, and difficulty completing the grief process. Women were categorized into five groups based on pregnancy outcomes, and four abortion decision types: Wanted, Inconsistent, Unwanted, or Coerced.</p><p><strong>Results: </strong>Among women with a history of abortion (n=409), negative emotions were reported more intensely than relief. Relief was the predominant emotion only among the 29.8% of women whose abortions were freely wanted and consistent with their own values and preferences. For all other groups, relief was low and negative emotions were more prominent. Emotions following natural pregnancy losses were similar to those following abortion, but less severe following wanted abortions and more severe following coerced abortions.</p><p><strong>Conclusions: </strong>Relief is only common after freely wanted abortions. Most abortions are inconsistent or contrary to women's own values. In these cases, strong negative emotions are far more dominant than relief. These results should inform pre-abortion screening, counseling supportive of women's own values and preferences, and mental health support post-abortion.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"240"},"PeriodicalIF":0.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11933783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eye-gesture control of computer systems via artificial intelligence.","authors":"Nachaat Mohamed","doi":"10.12688/f1000research.144962.3","DOIUrl":"10.12688/f1000research.144962.3","url":null,"abstract":"<p><strong>Background: </strong>Artificial Intelligence (AI) offers transformative potential for human-computer interaction, particularly through eye-gesture recognition, enabling intuitive control for users and accessibility for individuals with physical impairments.</p><p><strong>Methods: </strong>We developed an AI-driven eye-gesture recognition system using tools like OpenCV, MediaPipe, and PyAutoGUI to translate eye movements into commands. The system was trained on a dataset of 20,000 gestures from 100 diverse volunteers, representing various demographics, and tested under different conditions, including varying lighting and eyewear.</p><p><strong>Results: </strong>The system achieved 99.63% accuracy in recognizing gestures, with slight reductions to 98.9% under reflective glasses. These results demonstrate its robustness and adaptability across scenarios, confirming its generalizability.</p><p><strong>Conclusions: </strong>This system advances AI-driven interaction by enhancing accessibility and unlocking applications in critical fields like military and rescue operations. Future work will validate the system using publicly available datasets to further strengthen its impact and usability.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"109"},"PeriodicalIF":0.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11876798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing common inferential mistakes when failing to reject the null-hypothesis.","authors":"Amand Schmidt","doi":"10.12688/f1000research.158434.2","DOIUrl":"10.12688/f1000research.158434.2","url":null,"abstract":"<p><p>Failure to reject a null-hypothesis may lead to erroneous conclusions regarding the absence of an association or inadequate statistical power. Because an estimate (and its variance) can never be exactly zero, traditional statistical tests cannot conclusively demonstrate the absence of an association. Instead, estimates of accuracy should be used to identify settings in which an association and its variability are sufficiently small to be clinically acceptable, directly providing information on safety and efficacy. Post-hoc power calculations should be avoided, as they offer no additional information beyond statistical tests and p-values. Furthermore, post-hoc power calculations can be misleading because of an inability to distinguish between results based on insufficient sample size and results that reflect clinically irrelevant differences. Most multiple testing procedures unrealistically assume that all positive results are false positives. However, in applied settings, results typically represent a mix of true and false positives. This implies that multiplicity corrections do not effectively differentiate between true and false positives. Instead, considering the distributions of p-values and the proportion of significant results can help to identify bodies of evidence unlikely to be driven by false-positive results. In conclusion, rather than attempting to categorize results as true or false, medical research should embrace established statistical methods that focus on estimation accuracy, replication, and consistency.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1488"},"PeriodicalIF":0.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A streamlined workflow for long-read DNA methylation analysis with NanoMethViz and Bioconductor.","authors":"Shian Su, Lucinda Xiao, James Lancaster, Tamara Cameron, Kelsey Breslin, Peter F Hickey, Marnie E Blewitt, Quentin Gouil, Matthew E Ritchie","doi":"10.12688/f1000research.155204.2","DOIUrl":"https://doi.org/10.12688/f1000research.155204.2","url":null,"abstract":"<p><p>Long-read sequencing technologies have transformed the field of epigenetics by enabling direct, single-base resolution detection of DNA modifications, such as methylation. This produces novel opportunities for studying the role of DNA methylation in gene regulation, imprinting, and disease. However, the unique characteristics of long-read data, including the modBAM format and extended read lengths, necessitate the development of specialised software tools for effective analysis. The NanoMethViz package provides a suite of tools for loading in long-read methylation data, visualising data at various data resolutions. It can convert the data for use with other Bioconductor software such as bsseq, DSS, dmrseq and edgeR to discover differentially methylated regions (DMRs). In this workflow article, we demonstrate the process of converting modBAM files into formats suitable for comprehensive downstream analysis. We leverage NanoMethViz to conduct an exploratory analysis, visually summarizing differences between samples, examining aggregate methylation profiles across gene and CpG islands, and investigating methylation patterns within specific regions at the single-read level. Additionally, we illustrate the use of dmrseq for identifying DMRs and show how to integrate these findings into gene-level visualization plots. Our analysis is applied to a triplicate dataset of haplotyped long-read methylation data from mouse neural stem cells, allowing us to visualize and compare the characteristics of the parental alleles on chromosome 7. By applying DMR analysis, we recover DMRs associated with known imprinted genes and visualise the methylation patterns of these genes summarised at single-read resolution. Through DMR analysis, we identify DMRs associated with known imprinted genes and visualize their methylation patterns at single-read resolution. This streamlined workflow is adaptable to common experimental designs and offers flexibility in the choice of upstream data sources and downstream statistical analysis tools.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1243"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"All-cause mortality according to COVID-19 vaccination status: An analysis of the UK office for National statistics public data.","authors":"Marco Alessandria, Giovanni Malatesta, Giovanni Di Palmo, Marco Cosentino, Alberto Donzelli","doi":"10.12688/f1000research.154058.2","DOIUrl":"https://doi.org/10.12688/f1000research.154058.2","url":null,"abstract":"<p><strong>Background: </strong>The mass vaccination campaign against COVID-19 has been commonly considered the best response to the global COVID-19 pandemic crisis. However, assessment of its real-world effect can be performed by analysis of all-cause mortality by vaccination status. The UK is perhaps the only country which has made publicly available all-cause mortality data by vaccination status.</p><p><strong>Methods: </strong>Data from April 2021 to May 2023 published by the UK Office for National Statistics (ONS) were retrospectively analyzed by age groups and vaccination status; the standardized mortality ratio (SMR) for all-cause and non-COVID-19 mortality was calculated against the corresponding unvaccinated groups.</p><p><strong>Results: </strong>We found that across all age groups, all-cause mortality SMRs increased from a certain date, dependent on the age group. Across all age groups, all-cause mortality SMRs were initially much lower than 1. However, due to their increase, by a certain date for the 18-39, 80-89 and 90+ age groups they exceeded the reference value. For the other age groups, the date at which the SMR would reach 1 can be predicted, provided the trend is maintained. Non-COVID-19 SMRs' trends were very similar. Their initial values much lower than 1 are suggestive of significant biases in the ONS dataset, leading to underestimate the risks for the vaccinated people, as it is implausible that COVID-19 vaccines protect against non-COVID-19 deaths.</p><p><strong>Conclusions: </strong>The increase over time in all-cause death SMRs in vaccinated people compared to unvaccinated, and their excess from the reference values for certain age groups, should be carefully considered to understand the underlying factors. Furthermore, since the initial values of the SMRs are much lower than 1, we assume the presence of significant biases in the ONS dataset, leading to understimate the risks for the vaccinated people, as it is implausible that COVID-19 vaccines protect against non-COVID-19 deaths. It would be desirable for other major countries to systematically collect all-cause mortality by vaccination status and, in the meantime, a pending indepth investigations, much greater caution should be exercised in promoting mass vaccination campaigns.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"886"},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: <i>Hymenolepis diminuta</i> in an asymptomatic Ecuadorian child.","authors":"Zulbey Rivero de Rodriguez, Ader Ponce, Anthony Vera, Angela Bracho, Anita Murillo","doi":"10.12688/f1000research.155856.2","DOIUrl":"10.12688/f1000research.155856.2","url":null,"abstract":"<p><strong>Background: </strong>The cestode <i>Hymenolepis diminuta</i> is a cosmopolitan parasite, which in the adult stage is usually found in the small intestine of rats and accidentally in humans.</p><p><strong>Case report: </strong>We describe the finding of eggs of this parasite in an asymptomatic 3-year-old child. The child had extremely high IgE values of 1,376 IU/ml. After receiving treatment with Albendazole suspension 400mg/20mL, on the 10th day post-treatment, he showed no <i>H. diminuta</i> eggs in his fecal matter.</p><p><strong>Conclusions: </strong>Detailed morphological review of <i>Hymenolepis nana</i>-like eggs is recommended to distinguish them from <i>H. diminuta</i> eggs.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1119"},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11822246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}