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Unsteady MHD flow of tangent hyperbolic ternary hybrid nanofluid in a darcy-forchheimer porous medium over a permeable stretching sheet with variable thermal conductivity. 切向双曲型三元杂化纳米流体在达西-福尔海默多孔介质中通过可变导热系数的可渗透拉伸片的非定常MHD流动。
F1000Research Pub Date : 2025-03-10 eCollection Date: 2025-01-01 DOI: 10.12688/f1000research.158629.2
Asfaw Tsegaye Moltot, Eshetu Haile Gorfie, Gurju Awgichew Zergaw, Hunegnaw Dessie
{"title":"Unsteady MHD flow of tangent hyperbolic ternary hybrid nanofluid in a darcy-forchheimer porous medium over a permeable stretching sheet with variable thermal conductivity.","authors":"Asfaw Tsegaye Moltot, Eshetu Haile Gorfie, Gurju Awgichew Zergaw, Hunegnaw Dessie","doi":"10.12688/f1000research.158629.2","DOIUrl":"10.12688/f1000research.158629.2","url":null,"abstract":"<p><strong>Background: </strong>This research investigates the unsteady magnetohydrodynamic (MHD) flow, heat, and mass transfer of tangent hyperbolic ternary hybrid nanofluids over a permeable stretching sheet. The study considers three types of nanoparticles-aluminum oxide (Al₂O₃), copper (Cu), and titanium oxide (TiO₂)-dispersed in a base fluid of ethylene glycol (C₂H₆O₂). This ternary hybrid nanofluid (Al₂O₃-Cu-TiO₂/C₂H₆O₂) has potential applications in cooling systems, biomedical uses for targeted drug delivery and hyperthermia treatments, heat exchangers, and polymer processing techniques like extrusion and casting.</p><p><strong>Methods: </strong>This study will examine the combined effects of Weissenberg number, power law index, nanoparticle volume fraction, viscous dissipation, magnetic field, heat generation, nonlinear thermal radiation, temperature ratio, Joule heating, Brownian motion, thermophoresis, porous permeability, variable thermal conductivity, Eckert number, Prandtl number, Schmidt number, chemical reaction, velocity ratio, and Forchheimer number on the electrical conductivity of unsteady flow in tangent hyperbolic ternary hybrid nanofluids. The governing equations are transformed into similarity equations using appropriate transformations and solved numerically with the MATLAB BVP5C package. The results are validated against data from published articles to ensure reproducibility.</p><p><strong>Results: </strong>The findings reveal that an increase in the Weissenberg and Forchheimer numbers reduces the velocity profile, while the temperature distribution increases. The variable thermal conductivity parameter (Γ) leads to a higher temperature profile, indicating improved heat transfer. Higher nanoparticle concentrations in the nanofluids and hybrid nanofluids result in enhanced skin friction, Nusselt number, and Sherwood number. Ternary hybrid nanofluids show the most significant improvement in heat transfer and thermal conductivity.</p><p><strong>Conclusions: </strong>Ternary hybrid nanofluids significantly enhance heat and mass transfer, showing potential for applications in cooling systems, drug delivery, and polymer processing. The numerical results are consistent with previous research, confirming the reliability and reproducibility of the findings.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"152"},"PeriodicalIF":0.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case Report: Total intragastric mesh migration six years after diaphragmatic rupture and hiatal hernia surgery. 病例报告:膈破裂和裂孔疝手术后6年的全胃内补片移位。
F1000Research Pub Date : 2025-03-07 eCollection Date: 2023-01-01 DOI: 10.12688/f1000research.139090.2
Asma Sghaier, Mohamed Amine Elghali, Abdelrahmen Daadoucha, Amal Letaief, Itimed Gharbi, Fehmi Hamila, Sabri Youssef
{"title":"Case Report: Total intragastric mesh migration six years after diaphragmatic rupture and hiatal hernia surgery.","authors":"Asma Sghaier, Mohamed Amine Elghali, Abdelrahmen Daadoucha, Amal Letaief, Itimed Gharbi, Fehmi Hamila, Sabri Youssef","doi":"10.12688/f1000research.139090.2","DOIUrl":"10.12688/f1000research.139090.2","url":null,"abstract":"<p><strong>Background: </strong>Mesh implementation to repair the hiatal space is already justified. Nevertheless, the use of this procedure is debated in regard of complications that may occur. Mesh erosion and migration are considered the most serious complications of mesh repairs.</p><p><strong>Case presentation: </strong>It has not yet been well described in the literature. We describe a case of mesh erosion of stomach, many years later after a prosthetic repair of a diaphragmatic rupture associated to hiatal hernia, is presented here because of its rarity.</p><p><strong>Conclusion: </strong>Few explanations have been put forward to explain this incident. Could it be due to inflammatory processes, or to the composition of the Meshes? As yet, there is no definitive explanation.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"12 ","pages":"871"},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11904395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment to determine the accuracy of Chaillet and Demirjian method of dental age estimation using Orthopantomographs, Eastern Province, Saudi Arabia. 沙特阿拉伯东部省,用骨层析成像法评估Chaillet和Demirjian牙龄的准确性。
F1000Research Pub Date : 2025-03-06 eCollection Date: 2024-01-01 DOI: 10.12688/f1000research.157275.2
Faraz Mohammed, Arishiya Thapasum Fairozekhan, Intisar Ahmad Siddiqui, Saud AlMoumen, Turki Ali AlShehri, Maria Hassan AlRssasi, Abdullah Amer AlJami, Doha Mohsen AlRamadan, Ashwin C Shetty, Majed Mohammed Alfarea, Omar Suhaym, Nasser S AlShahrani
{"title":"Assessment to determine the accuracy of Chaillet and Demirjian method of dental age estimation using Orthopantomographs, Eastern Province, Saudi Arabia.","authors":"Faraz Mohammed, Arishiya Thapasum Fairozekhan, Intisar Ahmad Siddiqui, Saud AlMoumen, Turki Ali AlShehri, Maria Hassan AlRssasi, Abdullah Amer AlJami, Doha Mohsen AlRamadan, Ashwin C Shetty, Majed Mohammed Alfarea, Omar Suhaym, Nasser S AlShahrani","doi":"10.12688/f1000research.157275.2","DOIUrl":"10.12688/f1000research.157275.2","url":null,"abstract":"<p><strong>Background: </strong>The approach to estimating mandibular age has been widely used, although it has shown age estimation disparities in diverse populations, including Indians.</p><p><strong>Objective: </strong>Our goal was to test the Demirjian 8-teeth approach utilizing orthopantomogram to estimate age reliably after incorporating the third molar. We also used Chaillet and Demirjian's regression equations to estimate age estimation accuracy in the Eastern Province of Saudi Arabia.</p><p><strong>Methods: </strong>The retrospective study included 196 people. Individuals were 8-24 years old. The left mandibular teeth were staged using an orthopantomographs utilizing the Demirjian 8-teeth approach. The Chaillet and Demirjian's regression models determined dental age, and statistical methods compared dental age to chronological age.</p><p><strong>Results: </strong>The gender breakdown was 49.5% male and 50.5% female. Gender did not significantly affect chronological mean age or estimated mean age (13.39±3.77 vs. 13.10±3.51, p = 0.583; 11.75±2.92 vs. 11.58±2.70, p = 0.674). Statistically substantial differences in chronological and estimated mean ages between male and female individuals (p<0.001). Out of the total participants, 31.6% had a difference in age of ±1 year, 30.6% had a difference of 1-2 years, and 37.8% had a difference of more than 2 years. Compared to chronological and estimated ages, these variations in age between males and females were not statistically significant (p=0.557).</p><p><strong>Conclusions: </strong>The findings of this study support the use of Demirjian's 8-teeth approach in the Saudi population residing in the Eastern Province of the Kingdom of Saudi Arabia, employing Chaillet and Demirjian's regression equations.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1554"},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11890266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vancomycin Population Pharmacokinetic Models in Non- Critically Ill Adults Patients: a scoping review. 成人非危重病人万古霉素群体药代动力学模型:范围综述。
F1000Research Pub Date : 2025-03-06 eCollection Date: 2022-01-01 DOI: 10.12688/f1000research.128260.2
Diego Nivia, Juan-David Vivas, Wilson Briceño, Daniel Parra, Manuel Mena, Diego Jaimes, Juan-Francisco Guevara, Rosa Helena Bustos
{"title":"Vancomycin Population Pharmacokinetic Models in Non- Critically Ill Adults Patients: a scoping review.","authors":"Diego Nivia, Juan-David Vivas, Wilson Briceño, Daniel Parra, Manuel Mena, Diego Jaimes, Juan-Francisco Guevara, Rosa Helena Bustos","doi":"10.12688/f1000research.128260.2","DOIUrl":"10.12688/f1000research.128260.2","url":null,"abstract":"<p><strong>Background: </strong>Vancomycin is an effective first-line therapy primarily in methicillin-resistant Staphylococcus aureus (MRSA) infection and Clostridium difficile, however, it has been shown that its effectiveness and the reduction of nephrotoxicity depend on maintaining adequate therapeutic levels. Population pharmacokinetic (PopPk) models attempt to parameterize the behavior of plasma concentrations in different target populations and scenarios such as renal replacement therapy, to successful therapeutic outcome and avoid these side effects.</p><p><strong>Methods: </strong>A scoping review was conducted following the guidelines of Preferred Reporting Items for Systematic reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR), through a search in PubMed, LILACS, OVID Medline, Scopus, Web of Science, SAGE Journals, Google Scholar and previous known registers of PopPk models in non-critically ill adult patients, published between 1998 and 2024.</p><p><strong>Results: </strong>A total of 190 papers were fully screened, of which were included 36 studies conducted in different populations; 12 in general population, 23 in special populations (surgical, with impaired renal function, obese, elderly, with cancer and cystic fibrosis), and 1 in mixed population (general and with cancer). The main parameters in the models were renal clearance and volume of distribution. The principal covariables that affected the models were creatinine clearance and weight. All studies used internal evaluation and 4 of them used an external group.</p><p><strong>Discussion: </strong>The technology for the development and implementation of PopPk models requires experts in clinical pharmacology and is limited to university and research centers. The software is mostly expensive and, in most cases, the pharmacokinetic models and the heterogeneity in the parameters and evaluation methods depend on which compartmental model, parameters, covariates and software have been used.</p><p><strong>Conclusions: </strong>These models require validation in the clinical context and conducting experiments to adapt them for precision dosing in different subpopulations.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"11 ","pages":"1513"},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complications following miniplate insertion in maxillofacial fractures: a systematic review. 颌面部骨折微型钢板置入后的并发症:系统回顾。
F1000Research Pub Date : 2025-03-06 eCollection Date: 2024-01-01 DOI: 10.12688/f1000research.159017.2
Bramasto Purbo Sejati, Ahmad Kusumaatmaja, Maria Goreti Widiastuti, Tetiana Haniastuti
{"title":"Complications following miniplate insertion in maxillofacial fractures: a systematic review.","authors":"Bramasto Purbo Sejati, Ahmad Kusumaatmaja, Maria Goreti Widiastuti, Tetiana Haniastuti","doi":"10.12688/f1000research.159017.2","DOIUrl":"10.12688/f1000research.159017.2","url":null,"abstract":"<p><strong>Background: </strong>Maxillofacial fractures, frequently arising from road traffic incidents, falls, and acts of interpersonal aggression, are a considerable public health issue, exhibiting diverse epidemiological patterns according to demographic factors. The application of miniplates for fracture stabilization is a recognized technique, with innovative methods such as 3D plate systems emerging. Nonetheless, consequences including infections and hardware malfunctions persist. This systematic review seeks to present current evidence regarding the complications linked to miniplate placement in maxillofacial fractures over the last ten years.</p><p><strong>Methods: </strong>A systematic review was performed in accordance with PRISMA principles. Databases such as the Cochrane Library, PubMed, and Scopus were examined from September 2014 to September 2024. Studies documenting problems related to miniplate placement were included, without language constraints. The ROBINS-I tool was utilized for non-randomized studies, whereas the Cochrane risk of bias tool was applied to randomized controlled trials.</p><p><strong>Results: </strong>From 2,289 initially found studies, 56 satisfied the inclusion criteria. Among these, 28 employed interventional designs, whilst the remaining 28 were observational research. The predominant problems documented in several investigations encompassed infection, wound dehiscence, malocclusion, paraesthesia, malunion/non-union, segment movement, hardware failure, and palpable hardware. Advanced methodologies such as 3D plate systems and locking mechanisms were linked to diminished complication rates.</p><p><strong>Conclusion: </strong>This systematic analysis presents a decade of updated research about problems associated with miniplate placement in maxillofacial fractures. Novel methodologies such as 3D plate systems and locking mechanisms demonstrate promise in mitigating problems relative to conventional techniques. These findings can facilitate informed decision-making in clinical practice. Additional study utilizing standardized outcomes and prospective designs is essential to enhance comprehension of the long-term effects of miniplate utilization.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1507"},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role, function, and expectations of research funding committees: Perspectives from committee members. 研究资助委员会的角色、功能和期望:委员会成员的观点。
F1000Research Pub Date : 2025-03-06 eCollection Date: 2024-01-01 DOI: 10.12688/f1000research.154665.2
Amanda Blatch-Jones, Cherish Boxall, Katie Meadmore
{"title":"Role, function, and expectations of research funding committees: Perspectives from committee members.","authors":"Amanda Blatch-Jones, Cherish Boxall, Katie Meadmore","doi":"10.12688/f1000research.154665.2","DOIUrl":"10.12688/f1000research.154665.2","url":null,"abstract":"<p><p>Research funding committees play an integral role in the research funding process, consisting of a range of skills, knowledge, and expertise (e.g., professional, and public contributors). Although there is some evidence that has explored the efficiency and effectiveness of funding committees in terms of the funding process, there is a lack of published evidence about the purpose, role, and function of funding committees, from the perspective of committee members. A subset of survey data from a cohort of six National Institute for Health and Care Research (NIHR) research programmes, exploring the purpose of a funding committee, and the expectations and role of a funding committee member between October 2020 to December 2021. All committee members were eligible to participate in the survey. Using an inductive approach, 50 completed responses (22.5% response rate) were analysed, focusing on the role of a funding committee member and the functions of a funding committee. Participants highlighted seven key areas for the purpose of a funding committee: prioritising and recommending what research to fund (n=36) and assessment of quality (n=24) being the most common responses. Four areas were considered important to the expectations and role of funding committee members, with reviewing, critically appraising, and discussing applications (n=44); and being fair, objective, and unbiased (n=27) being the most common responses. The findings offer a unique insight into committee members' expectations about the role, purpose and function of a funding committee and their contribution to the funding recommendation process. There was high agreement that the purpose and role of committees and their members was to offer expert advice to make fair, impartial decisions on which research should be prioritised. Exploring the purpose, role, and function of funding committees has relevance and importance for funding organisations seeking to enhance and optimise the decision-making practice of funding committees.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1066"},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11826072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Measuring life satisfaction of self-help groups: Role of perceived social support and social empowerment. 自助群体生活满意度的测量:感知社会支持与社会赋权的作用。
F1000Research Pub Date : 2025-03-06 eCollection Date: 2025-01-01 DOI: 10.12688/f1000research.148209.2
Suraksha Suvarna, Satish Kumar, Navin Kumar Koodamara
{"title":"Measuring life satisfaction of self-help groups: Role of perceived social support and social empowerment.","authors":"Suraksha Suvarna, Satish Kumar, Navin Kumar Koodamara","doi":"10.12688/f1000research.148209.2","DOIUrl":"10.12688/f1000research.148209.2","url":null,"abstract":"<p><strong>Background: </strong>This study was designed to investigate the mediation effects of social empowerment (SE) in the relationship between perceived social support (PSS) and life satisfaction (LS) in women self-help group members. Also, this research attempted to understand the moderating effect of decision making (DM) and external communication (EC) on the relationship between the constructs.</p><p><strong>Methods: </strong>To achieve the above objective, the primary data were collected from the self-help group women members by using an existing scale. In this survey, 333 participants who are members of self-help group completed the questionnaire and considered for the study. The study is non-experimental and survey-based, with no interventions or manipulations involved. In line with ethical guidelines, we obtained informed consent directly from each respondent before their participation.</p><p><strong>Conclusion: </strong>The path coefficient values, t-statistics and P-Values confirmed the positive relationship between PSS->LS; PSS->SE & SE->LS in women self-group members. PLS structural equation modelling estimated by the bootstrap method revealed that SE partially mediates the relationship between PSS & LS. With regard to the interaction effect, the slope analysis and f <sup>2</sup> effect size confirmed the moderating effect of EC in the relationship between PSS -> LS & SE -> LS.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"101"},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11947657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Morphological and Molecular Characterization of Trichoderma Isolates from Vegetable Crop Rhizospheres in Nepal. 尼泊尔蔬菜作物根际分离木霉的形态和分子特征。
F1000Research Pub Date : 2025-03-05 eCollection Date: 2024-01-01 DOI: 10.12688/f1000research.153701.2
Puja Jaiswal, Ram B Khadka, Aashaq Hussain Bhat, Suraj Baidya, Arvind Kumar Keshari
{"title":"Morphological and Molecular Characterization of <i>Trichoderma</i> Isolates from Vegetable Crop Rhizospheres in Nepal.","authors":"Puja Jaiswal, Ram B Khadka, Aashaq Hussain Bhat, Suraj Baidya, Arvind Kumar Keshari","doi":"10.12688/f1000research.153701.2","DOIUrl":"10.12688/f1000research.153701.2","url":null,"abstract":"<p><strong>Background: </strong><i>Trichoderma</i> spp. hold significant potential as biocontrol agents in agriculture due to their antagonistic properties against plant pathogens. The study aimed to characterize and identify <i>Trichoderma</i> isolates from rhizospheric regions of vegetable crops.</p><p><strong>Methods: </strong>In this study, <i>Trichoderma</i> isolates were collected from rhizospheric soil samples of vegetable crops from different ecological zones and were selected for comprehensive morphological and molecular characterization. The isolates were visually assessed for colony color, growth pattern, aerial mycelium presence, phialide and conidial morphology, and chlamydospore presence. Molecular analysis was employed based on ITS and tef-1α sequences. Diversity indices were also computed for different ecological zones.</p><p><strong>Results: </strong>The morphological characteristics and phylogenetic trees for both regions provided a clear species resolution, with four main clades: <i>Harzianum, Viride, Brevicompactum</i> and <i>Longibrachiatum</i> with 12 species <i>T. harzinaum</i>, <i>T. afroharzianum, T. lentiforme, T. inhamatum, T. camerunense, T. azevedoi</i>, <i>T. atroviride, T. asperellum, T. asperelloides, T. koningii, T. longibrachiatum</i> and <i>T. brevicompactum</i> and nine species as a new country record. Diversity indices indicated that high mountain regions displayed the highest species diversity and evenness (H = 1.724 [0.28], J = 0.84, D = 0.28), followed by hilly regions (H = 1.563 [0.28], J = 0.72, D = 0.28). Plains, on the other hand, exhibited lower species diversity (H = 1.515, J = 0.66, D = 0.33). The calculated species abundance values showed that plains (E = 2.11), mid-hills (E = 1.95), and high mountains (E = 1.99) each had their unique diversity profiles. Notably, <i>T. afroharzianum</i> and <i>T. asperellum</i> were predominant.</p><p><strong>Conclusions: </strong>Overall, the study unveiled a rich diversity of <i>Trichoderma</i> species in different agricultural zones of Nepal. These findings shed light on the ecological distribution and diversity of <i>Trichoderma</i> spp., which could have significant implications for sustainable agriculture and biological control strategies.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1088"},"PeriodicalIF":0.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analyzing Molecular Traits of H9N2 Avian Influenza Virus Isolated from a Same Poultry Farm in West Java Province, Indonesia, in 2017 and 2023. 2017年和2023年印度尼西亚西爪哇省同一家禽养殖场分离H9N2禽流感病毒分子特征分析
F1000Research Pub Date : 2025-03-05 eCollection Date: 2024-01-01 DOI: 10.12688/f1000research.150975.2
Muhammad Ade Putra, Amin Soebandrio, I Wayan Teguh Wibawan, Christian Marco Hadi Nugroho Nugroho, Ryan Septa Kurnia, Otto Sahat Martua Silaen, Rifky Rizkiantino, Agustin Indrawati, Okti Nadia Poetri, Desak Gede Budi Krisnamurti
{"title":"Analyzing Molecular Traits of H9N2 Avian Influenza Virus Isolated from a Same Poultry Farm in West Java Province, Indonesia, in 2017 and 2023.","authors":"Muhammad Ade Putra, Amin Soebandrio, I Wayan Teguh Wibawan, Christian Marco Hadi Nugroho Nugroho, Ryan Septa Kurnia, Otto Sahat Martua Silaen, Rifky Rizkiantino, Agustin Indrawati, Okti Nadia Poetri, Desak Gede Budi Krisnamurti","doi":"10.12688/f1000research.150975.2","DOIUrl":"10.12688/f1000research.150975.2","url":null,"abstract":"<p><strong>Background: </strong>Indonesia is one of the countries that is endemic to avian influenza virus subtype H9N2. This study aims to compare the molecular characteristics of avian influenza virus (AIV) subtype H9N2 from West Java.</p><p><strong>Methods: </strong>Specific pathogen-free (SPF) embryonated chicken eggs were used to inoculate samples. RNA extraction and RT-qPCR confirmed the presence of H9 and N2 genes in the samples. RT-PCR was employed to amplify the H9N2-positive sample. Nucleotide sequences were obtained through Sanger sequencing and analyzed using MEGA 7. Homology comparison and phylogenetic tree analysis, utilizing the neighbor-joining tree method, assessed the recent isolate's similarity to reference isolates from GenBank. Molecular docking analysis was performed on the HA1 protein of the recent isolate and the A/Layer/Indonesia/WestJava-04/2017 isolate, comparing their interactions with the sialic acids Neu5Ac2-3Gal and Neu5Ac2-6Gal.</p><p><strong>Results: </strong>RT-qPCR confirmed the isolate samples as AIV subtype H9N2. The recent virus exhibited 11 amino acid residue differences compared to the A/Layer/Indonesia/WestJava-04/2017 isolate. Phylogenetically, the recent virus remains within the h9.4.2.5 subclade. Notably, at antigenic site II, the recent isolate featured an amino acid N at position 183, unlike A/Layer/Indonesia/WestJava-04/2017. Molecular docking analysis revealed a preference of HA1 from the 2017 virus for Neu5Ac2-3Gal, while the 2023 virus displayed a tendency to predominantly bind with Neu5Ac2-6Gal.</p><p><strong>Conclusion: </strong>In summary, the recent isolate displayed multiple mutations and a strong affinity for Neu5Ac2-6Gal, commonly found in mammals.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"571"},"PeriodicalIF":0.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11602698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Teaching Self-efficacy and Teaching Methods in the Aquatic Environment. 水生环境教学自我效能感与教学方法。
F1000Research Pub Date : 2025-03-04 eCollection Date: 2024-01-01 DOI: 10.12688/f1000research.150535.2
Rita Fonseca-Pinto, Juan Antonio Moreno-Murcia
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