F1000Research最新文献

{"title":"Novel gastrointestinal tools (GI Tools) for evaluating gut functional capacity in adults with environmental enteropathy in Zambia and Zimbabwe: A cross-sectional study protocol.","authors":"Tracy N Phiri, James W Weatherill, Elena Monford-Sanchez, Jose-Ivan Serrano-Contreras, Callum Melvin, Mirriam Kunaka, Ian Chisenga, Perpetual Ngalande, Monica N Mweetwa, Ellen Besa, Tafhima Haider, Nilanjan Mandal, Alex J Thompson, Christine A Edwards, Claire D Bourke, Ruairi C Robertson, Joram M Posma, Rosemary Banda, Mulima Mwiinga, Lydia Kazhila, Leolin Katsidzira, Mutsa Bwakura-Dangarembizi, Beatrice Amadi, Isabel Garcia-Perez, Kathryn Maitland, Julian R Marchesi, Douglas J Morrison, Gary Frost, Paul Kelly","doi":"10.12688/f1000research.154471.2","DOIUrl":"10.12688/f1000research.154471.2","url":null,"abstract":"<p><strong>Background: </strong>Environmental enteropathy (EE) is a highly prevalent subclinical inflammatory intestinal disorder associated with growth failure, impaired neurocognitive development, poor response to oral vaccines, and micronutrient deficiencies. However, EE research and clinical trials are hampered by the lack of non-invasive tools for measuring intestinal function in detail. This study aims to develop new tools for the measurement of multiple domains of gut functional capacity.</p><p><strong>Methods: </strong>The GI TOOLS project is a cross-sectional study that will recruit adults aged 18-65 years with EE in Lusaka, Zambia. Each participant will undergo assessment of gut functional capacity using novel near-point-of-care tools and provide multiple samples for detailed laboratory analyses. Participants will also undergo endoscopy for collection of duodenal biopsies. Novel techniques include stable isotopes approaches to measuring digestion, absorption, and bidirectional transmucosal amino acid flux, a non-invasive fluorescence tool for real-time evaluation of gut permeability, and assessment of reverse permeation of intravenous antibiotics to be carried out separately in Zimbabwe. Stool and duodenal microbiome sequencing using MinION sequencing, metabolome analysis applied to plasma and intestinal fluids, blood immune cell phenotyping, <i>in vitro</i> epithelial barrier models, and duodenal immunohistochemistry will also be used to explore EE in depth. These will all be integrated with gold standard histology and mucosal morphometry, alongside lactulose permeation data, and stool and plasma biomarker analysis. The protocol has been approved by ethics committees and regulators in Zambia, Zimbabwe, and the UK. Participants will give informed consent before they can participate.</p><p><strong>Anticipated outcomes: </strong>Based on this extensive phenotyping, tests will be developed which can be simplified and refined for use in adults and children with EE, and for clinical trials. Findings from this project will be disseminated through in-person meetings with caregivers and regulatory bodies, presentations at conferences and in peer-reviewed journals.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"956"},"PeriodicalIF":0.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with death in patients admitted with Ebola virus disease to Ebola Treatment Units in Guinea, Sierra Leone, and Liberia - December 2013 to March 2016.","authors":"Trokon Omarley Yeabah, Ibrahima Kaba, Gomathi Ramaswamy, Prabin Dahal, Alexandre Delamou, Benjamin T Vonhm, Ralph W Jetoh, Laura Merson, Adam C Levine, Pryanka Relan, Anthony D Harries, Ajay M V Kumar","doi":"10.12688/f1000research.149612.2","DOIUrl":"10.12688/f1000research.149612.2","url":null,"abstract":"<p><strong>Background: </strong>The 2013-2016 West African Ebola Virus Disease (EVD) outbreak resulted in 28,600 cases and 11,300 deaths officially reported to the World Health Organization. Previous studies investigating factors associated with death had conflicting findings, interventions showing promising outcomes had small sample sizes, studies were often single- or dual-country based and most focused on laboratory-confirmed EVD and not on clinically-suspected EVD. We used the Ebola data platform of the Infectious Disease Data Observatory (IDDO) to review individual patient records to assess factors associated with death, and particularly whether there were differences between laboratory-confirmed and clinically-suspected cases.</p><p><strong>Methods: </strong>This was a cohort study involving analysis of secondary data in the IDDO database. The study population included all patients classified as having either clinically-suspected or laboratory-confirmed EVD, admitted to 22 Ebola Treatment Units (ETU) in Guinea, Liberia and Sierra Leone between December 2013 and March 2016. Baseline characteristics and treatments were documented along with ETU exit outcomes. Factors associated with death were investigated by multivariable modified Poisson regression.</p><p><strong>Results: </strong>There were 14,163 patients, of whom 6,208 (43.8%) were laboratory-confirmed and 7,955 (56.2%) were clinically-suspected. Outcomes were not recorded in 2,889 (20.4%) patients. Of the 11,274 patients with known outcomes, 4,090 (36.3%) died: 2,956 (43.6%) with laboratory-confirmed EVD and 1,134 (18.8%) with clinically-suspected EVD. The strongest risk factor for death was confirmed disease status. Patients with laboratory-confirmed disease had 2.9 times higher risk of death compared to clinically-suspected patients, after adjusting for other co-variables. Other factors significantly associated with death included a higher risk for patients aged ≥60 years and a lower risk for patients in Sierra Leone.</p><p><strong>Conclusions: </strong>Although laboratory-confirmed patients admitted to ETUs fared worse than clinically-suspected patients, the latter still had a substantial risk of death and more attention needs to be paid to this group in future EVD outbreaks.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"672"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Predictive Power of Self-Care and Psychological Flow on Occupational Stress in Nurses.","authors":"Abdallah Salem Almahaireh, Baha' Suhail Shawaqfeh","doi":"10.12688/f1000research.152259.2","DOIUrl":"10.12688/f1000research.152259.2","url":null,"abstract":"<p><strong>Background: </strong>The nursing workforce is crucial in healthcare systems worldwide and contributes to community well-being. also, Nurses experience numerous psychological, social, emotional, and behavioral shocks and challenges in their work. In Jordan, 43% of doctors and nurses suffer from high levels of burnout, around 55% experience high levels of emotional exhaustion, and 33% of doctors and nurses suffer from high levels of psychological pressure and job stress. Others found that 70% of nurses experience stress. these issues can be reduced by practicing self-care and psychological flow which impact in work-related tasks which are important in effectively addressing occupational stress healthily and soundly. This study aims to determine assessing the predictive power of self-care and psychological flow in occupational stress among nurses.</p><p><strong>Methods: </strong>This study follows the quantitative technique. sample consisting of 476 nurses in Amman Jordan was chosen. Three scales were adapted to meet the study objectives: Occupational stress scale, Self-care scale, and psychological flow scale. There validity and reliability were checked.</p><p><strong>Results: </strong>The study results indicate that self-care and psychological flow levels were low with means of 2.32 and 2.13, while the occupational stress level was high with a mean of 3.91. Also, there are a predictive power of self-care and psychological flow in occupational stress among nurses.</p><p><strong>Conclusions: </strong>This study shows that of self-care and psychological flow predict occupational stress among nurses, which helps us to manage the occupational stress among them by giving them self-care and psychological flow practices and healing time during work by group counseling and lectures.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"641"},"PeriodicalIF":0.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11962362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eye-gesture control of computer systems via artificial intelligence.","authors":"Nachaat Mohamed","doi":"10.12688/f1000research.144962.3","DOIUrl":"10.12688/f1000research.144962.3","url":null,"abstract":"<p><strong>Background: </strong>Artificial Intelligence (AI) offers transformative potential for human-computer interaction, particularly through eye-gesture recognition, enabling intuitive control for users and accessibility for individuals with physical impairments.</p><p><strong>Methods: </strong>We developed an AI-driven eye-gesture recognition system using tools like OpenCV, MediaPipe, and PyAutoGUI to translate eye movements into commands. The system was trained on a dataset of 20,000 gestures from 100 diverse volunteers, representing various demographics, and tested under different conditions, including varying lighting and eyewear.</p><p><strong>Results: </strong>The system achieved 99.63% accuracy in recognizing gestures, with slight reductions to 98.9% under reflective glasses. These results demonstrate its robustness and adaptability across scenarios, confirming its generalizability.</p><p><strong>Conclusions: </strong>This system advances AI-driven interaction by enhancing accessibility and unlocking applications in critical fields like military and rescue operations. Future work will validate the system using publicly available datasets to further strengthen its impact and usability.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"109"},"PeriodicalIF":0.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11876798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A streamlined workflow for long-read DNA methylation analysis with NanoMethViz and Bioconductor.","authors":"Shian Su, Lucinda Xiao, James Lancaster, Tamara Cameron, Kelsey Breslin, Peter F Hickey, Marnie E Blewitt, Quentin Gouil, Matthew E Ritchie","doi":"10.12688/f1000research.155204.2","DOIUrl":"https://doi.org/10.12688/f1000research.155204.2","url":null,"abstract":"<p><p>Long-read sequencing technologies have transformed the field of epigenetics by enabling direct, single-base resolution detection of DNA modifications, such as methylation. This produces novel opportunities for studying the role of DNA methylation in gene regulation, imprinting, and disease. However, the unique characteristics of long-read data, including the modBAM format and extended read lengths, necessitate the development of specialised software tools for effective analysis. The NanoMethViz package provides a suite of tools for loading in long-read methylation data, visualising data at various data resolutions. It can convert the data for use with other Bioconductor software such as bsseq, DSS, dmrseq and edgeR to discover differentially methylated regions (DMRs). In this workflow article, we demonstrate the process of converting modBAM files into formats suitable for comprehensive downstream analysis. We leverage NanoMethViz to conduct an exploratory analysis, visually summarizing differences between samples, examining aggregate methylation profiles across gene and CpG islands, and investigating methylation patterns within specific regions at the single-read level. Additionally, we illustrate the use of dmrseq for identifying DMRs and show how to integrate these findings into gene-level visualization plots. Our analysis is applied to a triplicate dataset of haplotyped long-read methylation data from mouse neural stem cells, allowing us to visualize and compare the characteristics of the parental alleles on chromosome 7. By applying DMR analysis, we recover DMRs associated with known imprinted genes and visualise the methylation patterns of these genes summarised at single-read resolution. Through DMR analysis, we identify DMRs associated with known imprinted genes and visualize their methylation patterns at single-read resolution. This streamlined workflow is adaptable to common experimental designs and offers flexibility in the choice of upstream data sources and downstream statistical analysis tools.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1243"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"All-cause mortality according to COVID-19 vaccination status: An analysis of the UK office for National statistics public data.","authors":"Marco Alessandria, Giovanni Malatesta, Giovanni Di Palmo, Marco Cosentino, Alberto Donzelli","doi":"10.12688/f1000research.154058.2","DOIUrl":"https://doi.org/10.12688/f1000research.154058.2","url":null,"abstract":"<p><strong>Background: </strong>The mass vaccination campaign against COVID-19 has been commonly considered the best response to the global COVID-19 pandemic crisis. However, assessment of its real-world effect can be performed by analysis of all-cause mortality by vaccination status. The UK is perhaps the only country which has made publicly available all-cause mortality data by vaccination status.</p><p><strong>Methods: </strong>Data from April 2021 to May 2023 published by the UK Office for National Statistics (ONS) were retrospectively analyzed by age groups and vaccination status; the standardized mortality ratio (SMR) for all-cause and non-COVID-19 mortality was calculated against the corresponding unvaccinated groups.</p><p><strong>Results: </strong>We found that across all age groups, all-cause mortality SMRs increased from a certain date, dependent on the age group. Across all age groups, all-cause mortality SMRs were initially much lower than 1. However, due to their increase, by a certain date for the 18-39, 80-89 and 90+ age groups they exceeded the reference value. For the other age groups, the date at which the SMR would reach 1 can be predicted, provided the trend is maintained. Non-COVID-19 SMRs' trends were very similar. Their initial values much lower than 1 are suggestive of significant biases in the ONS dataset, leading to underestimate the risks for the vaccinated people, as it is implausible that COVID-19 vaccines protect against non-COVID-19 deaths.</p><p><strong>Conclusions: </strong>The increase over time in all-cause death SMRs in vaccinated people compared to unvaccinated, and their excess from the reference values for certain age groups, should be carefully considered to understand the underlying factors. Furthermore, since the initial values of the SMRs are much lower than 1, we assume the presence of significant biases in the ONS dataset, leading to understimate the risks for the vaccinated people, as it is implausible that COVID-19 vaccines protect against non-COVID-19 deaths. It would be desirable for other major countries to systematically collect all-cause mortality by vaccination status and, in the meantime, a pending indepth investigations, much greater caution should be exercised in promoting mass vaccination campaigns.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"886"},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Community preparedness for earthquake disasters: A preliminary assessment of awareness and disaster infrastructure response in Cianjur, West Java-Indonesia.","authors":"Dewayany Sutrisno, Yatin Suwarno, Ati Rahadiati, Muhammad Iqbal Habibie, Prabu Kresna Putra, Hari Prayogi, Amien Widodo, Fathia Zulfati Sabrina, Ahmad Kosasih","doi":"10.12688/f1000research.143577.3","DOIUrl":"10.12688/f1000research.143577.3","url":null,"abstract":"<p><strong>Background: </strong>The danger of earthquakes poses a serious threat to people worldwide. One of the most significant challenges is preparing communities to cope effectively with this disaster. Therefore, understanding earthquake hazards is critically important for preparedness, mitigation, and an effective response to this threat. This report aims to observe and conduct a preliminary assessment of the degree to which community preparedness for earthquake disasters has been implemented.</p><p><strong>Methods: </strong>Empirical data were obtained from survey respondents and interviews. The respondents were members of a community affected by the Cianjur earthquake, which occurred on November 21, 2022. The data were analysed using the mean range approach, based on Likert scales. Additionally, the Spearman correlation method was employed to indicate the relationship between community awareness and infrastructure readiness.</p><p><strong>Result: </strong>Based on empirical evidence and preliminary analysis, it is evident that the preparedness of the community to respond effectively to earthquake catastrophes is inadequate. An apparent lack of readiness is observed in the inadequate construction of housing that fails to meet disaster standards, and the absence of disaster response facilities is notable.</p><p><strong>Conclusions: </strong>Based on our initial assumption, it appears that knowledge related to disaster resilience in this area has not been adequately disseminated or socialized. However, this premise requires further investigation.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"256"},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: <i>Hymenolepis diminuta</i> in an asymptomatic Ecuadorian child.","authors":"Zulbey Rivero de Rodriguez, Ader Ponce, Anthony Vera, Angela Bracho, Anita Murillo","doi":"10.12688/f1000research.155856.2","DOIUrl":"10.12688/f1000research.155856.2","url":null,"abstract":"<p><strong>Background: </strong>The cestode <i>Hymenolepis diminuta</i> is a cosmopolitan parasite, which in the adult stage is usually found in the small intestine of rats and accidentally in humans.</p><p><strong>Case report: </strong>We describe the finding of eggs of this parasite in an asymptomatic 3-year-old child. The child had extremely high IgE values of 1,376 IU/ml. After receiving treatment with Albendazole suspension 400mg/20mL, on the 10th day post-treatment, he showed no <i>H. diminuta</i> eggs in his fecal matter.</p><p><strong>Conclusions: </strong>Detailed morphological review of <i>Hymenolepis nana</i>-like eggs is recommended to distinguish them from <i>H. diminuta</i> eggs.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1119"},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11822246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Through restful waters and deep commotion: A study on burnout and health impairment of Italian seafarers from the JD-R model perspective.","authors":"Francesco Buscema, Lorenzo Cena, Clarissa Cricenti, Margherita Zito, Lara Bertola, Lara Colombo","doi":"10.12688/f1000research.159198.1","DOIUrl":"10.12688/f1000research.159198.1","url":null,"abstract":"<p><strong>Background: </strong>The work experience of seafarers differs significantly from other land-based occupations due to several factors, particularly remoteness and the restricted work environment. This study seeks to examine the impact of burnout and health impairment in the maritime industry, using the Job Demand-Resources theory as a framework.</p><p><strong>Methods: </strong>To investigate these phenomena, an online questionnaire was sent to 629 Italian seafarers and we conducted analysis on a valid sample of 239 respondents (94.6% men, Mage = 39.44, SD = 12.8). We tested a mediated Structural Equation Model (SEM) aimed at predicting negative health outcomes.</p><p><strong>Results: </strong>The results show that burnout plays a mediating role between job demands (such as workload and cognitive strain) and health impairment (such as sleep quality and physical well-being) (Total Indirect Effect = 0.443, <i>p</i> < .0001) as well as between job resources (such as social support and transformational leadership) and health impairment (Total Indirect Effect = -0.249, <i>p</i> < .0001). Furthermore, the findings highlight the direct influence of occupational resources on seafarers' health.</p><p><strong>Conclusions: </strong>The discussion highlights the urgent need for more research in the field of organisational psychology in the maritime industry and the discrepancies between these findings, which are consistent with the existing maritime literature, and other studies that do not include seafarers in their sample groups.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"19"},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11751612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnitude and Factors Associated with Research Misconduct at a Public University in Ethiopia: A Cross-Sectional Survey.","authors":"Habtamu Belay Hailu, Telahun Teka Wolde, Betselot Yirsaw Wubete, Joseph Ali, Sintayehu Tsegaye Bitew","doi":"10.12688/f1000research.159997.2","DOIUrl":"10.12688/f1000research.159997.2","url":null,"abstract":"<p><strong>Background: </strong>Research integrity, essential for ethical scientific research, has been inadequately addressed in Ethiopia, resulting in gaps in addressing misconduct like plagiarism, falsification and fabrication. The aim of this study was to assess the magnitude and factors associated with research misconduct at a public university in Ethiopia.</p><p><strong>Methods: </strong>An institutional-based cross-sectional study was conducted on a random sample of researchers. Data were collected via a self-administered, structured questionnaire, which was adapted from a similar study. The collected data were analysed using descriptive, bivariate, and multivariable logistic regression.</p><p><strong>Result: </strong>A total of 244 researchers participated in the study, resulting in an 82% response rate. In our study, 37.7% of participants reported engaging in at least one form of misconduct, 95% CI [31.6%, 44.1%]. Authorship misconduct was the most common form of self-reported misconduct (47.5%), 95% CI [41.1%, 54.0%], followed by fabrication and falsification (40.6%), 95% CI [34.4%, 47.0%]. Publication pressure was significantly associated with research misconduct (AOR = 3.18; 95% CI: [1.02, 9.95]).</p><p><strong>Conclusion: </strong>This study highlights the prevalence of research misconduct and questionable research practices among academic researchers, with authorship misconduct, fabrication, falsification, and plagiarism being the most commonly reported types. Attitudes toward research misconduct and self-reported involvement were influenced by academic position, research experience, and publication pressure, with junior researchers being more likely to report engaging in misbehavior. While ethics training has occasionally been associated with reduced rates of research misconduct, its effectiveness remains uncertain, as institutional culture, supervision, and mentorship may play a more significant role. Addressing research misconduct requires a comprehensive approach that extends beyond ethical instruction, incorporating targeted support for early-career researchers, open dialogue, and institutional policy reforms.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"111"},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}