F1000Research最新文献

{"title":"Predicting stunting status among under-5 children in Rwanda using neural network model: Evidence from 2020 Rwanda demographic and health survey.","authors":"Similien Ndagijimana, Ignace Kabano, Emmanuel Masabo, Jean Marie Ntaganda","doi":"10.12688/f1000research.141458.2","DOIUrl":"10.12688/f1000research.141458.2","url":null,"abstract":"<p><strong>Background: </strong>Stunting is a serious public health concern in Rwanda, affecting around 33.3% of children under five in 2020. The researchers have employed machine learning algorithms to predict stunting in Rwanda; however, few studies used ANNs, despite their strong capacity to predict stunting. The purpose of this study was to predict stunting in Rwanda using ANNs and the most recent DHS data from 2020.</p><p><strong>Methods: </strong>DHS 2020 dataset was used to train and test an ANN model for predicting stunting in children. The dataset, which included various child, parental, and socio-demographic characteristics, was split into 80% training data and 20% testing and validation data. The model utilised a multilayer perceptron (MLP). Model performance was assessed using accuracy, precision, recall, and AUC-ROC. Feature importances were determined and highlighted the most critical predictors of stunting.</p><p><strong>Results: </strong>An overall accuracy of 72.0% on the test set was observed, with an AUC-ROC of 0.84, indicating the model's good performance. Factors appear to contribute to stunting among the negative value aspects. First and foremost, the mother's height is important, as a lower height suggests an increased risk of stunting in children. Positive value characteristics, on the other hand, emphasise elements that reduce the likelihood of stunting. The timing of the initiation of breastfeeding stands out as a crucial factor, showing that early breastfeeding initiation has been linked with a decreased risk of stunting.</p><p><strong>Conclusions: </strong>These findings suggest that ANNs can be a useful tool for predicting stunting in Rwanda and identifying the most important associated factors for stunting. These insights can inform targeted interventions to reduce the burden of stunting in Rwanda and other low- and middle-income countries. Potential targeted interventions include nutritional support programs for pregnant and lactating mothers, and providing educational programs for parents on nutrition and hygiene.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"128"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11840296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the dynamics of fee-free higher education in South Africa: a causal loop diagram approach .","authors":"Tlotlo Ramasu, Grace Kanakana-Katumba","doi":"10.12688/f1000research.152478.3","DOIUrl":"https://doi.org/10.12688/f1000research.152478.3","url":null,"abstract":"<p><strong>Background: </strong>This research investigated the dynamics of fee-free higher education in South Africa, analysing the interplay of socioeconomic, political, and institutional factors to elucidate the complexities surrounding its implementation and impact. Using a causal loop diagram approach (CLD), the study aims to identify key factors to effective implementation, how they interact to shape the outcome of the policy, and actionable strategies to address the challenges hindering the policy sustainability.</p><p><strong>Method: </strong>A participatory approach was used to developing the CLD, integrating insights from an extensive literature review and stakeholder opinion. The initial CLD was constructed based on evidence from prior research contextualizing fee-free higher education within South Africa's unique socio-political sector. Discussions with stakeholders and experts provided critical feedback to refine the model, ensuring its relevance and accuracy. The CLD methodology was selected for its ability to illustrate complex interdependencies and systemic challenges.</p><p><strong>Results: </strong>Key findings highlight the impact of funding constraints, which create reinforcing feedback loops limiting access and infrastructure improvements. Also, administrative inefficiencies within the National Student Financial Aid Scheme (NSFAS) result in delays and inconsistencies, reducing policy inclusivity, and decentralized implementation across institutions perpetuates disparities in quality and access.</p><p><strong>Conclusion: </strong>The study concludes the urgent need for systemic reforms, including digitising financial aid processes, centralising NSFAS operations, and improving resource allocation to under-resourced institutions. Furthermore, the study aligns with global goals, particularly Sustainable Development Goals (SDGs) 4 (Quality Education), 8 (Decent Work and Economic Growth), and 10 (Reduced Inequalities), as well as the African Agenda 2063's focus on human capital development. While the findings offer valuable recommendations for policymakers, further research is needed to explore longitudinal impacts of these reforms and expand comparative analyses with other nations implementing similar policies.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"780"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11775444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flexible modular dwelling for rural environments; specific case: Cebadas - Ecuador.","authors":"Karina Elizabeth Cajamarca Dacto, Jean Carlos Montero Riofrio, Erick Fabricio Nieto Páez, Dany Marcelo Tasan Cruz, Maikol Josueé González Espinosa","doi":"10.12688/f1000research.154417.2","DOIUrl":"10.12688/f1000research.154417.2","url":null,"abstract":"<p><strong>Background: </strong>Sustainable modular dwelling design for rural areas should focus on creating healthy and economically accessible spaces, sensitive to local needs and integrating environmental, functional, sociological and technological aspects. Flexibility is essential to reduce the initial investment and allow future transformations, optimizing the recovery and reuse of materials. These houses must be adaptable, safe and have basic services, satisfying the needs and stages of families' development. In Ecuador, poverty and energy inefficiency worsen the quality of life in rural areas. This project in the Cebadas parish proposes modular dwelling that applies bioclimatic and sustainable criteria, using local materials to improve habitability and promote the social and economic development of the community.</p><p><strong>Method: </strong>The research approach is qualitative-quantitative. Qualitative, since it is necessary to identify the qualities of the sector, bibliographic exploration of guidelines and sustainable strategies. Quantitative, to evaluate the degree of affectation through a diagnosis of the study site and to provide efficient solutions that respond to the context and social reality.</p><p><strong>Results: </strong>The spaces presented in the proposal respond to the spatial need for growth and expansion of the users of the sector, through 6 basic guidelines that this type of dwelling should have: Environment, Visual, Form, Function, Bioclimatic and Materials.</p><p><strong>Conclusions: </strong>The flexible modular dwelling project for rural environments addresses complex housing needs, highlighting the flexibility and adaptability of an expandable module. It includes income generation with a duplex apartment, fosters communal and cultural life with public and commercial spaces, promotes tourism and rural development with landscape design and crops. In addition, it ensures sustainability through bioclimatic strategies and responsible use of resources.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"845"},"PeriodicalIF":0.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11751609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genotoxic effects in island populations of Cartagena de Indias, Colombia due to environmental exposure to mercury and cadmium.","authors":"Eder Cano-Pérez, Doris Gómez-Camargo, Dacia Malambo-García","doi":"10.12688/f1000research.154617.3","DOIUrl":"10.12688/f1000research.154617.3","url":null,"abstract":"<p><strong>Background: </strong>Contamination of Cartagena Bay, Colombia with heavy metals such as mercury (Hg) and cadmium (Cd) presents a major environmental and public health concern, particularly for human communities residing on nearby islands and coastal areas. These populations face enhanced exposure risks owing to their traditional fishing practices and continuous interactions with polluted marine environments. This study aimed to evaluate the genotoxic effects of environmental exposure to Hg and Cd in populations from the island zone of the Cartagena district, Bolívar.</p><p><strong>Methods: </strong>Ninety-four individuals from the four island communities (study group) and 30 individuals from the urban area of Cartagena (control group) participated in this study. The blood samples were collected to measure total mercury (T-Hg) and Cd concentrations, and a Buccal Micronucleus Cytome (BMCyt) assay was used to evaluate exposure effects.</p><p><strong>Results: </strong>Cadmiun levels in the blood of the study group were within the normal range and comparable to those of the control group (p > 0.05). However, the study group exhibited significantly higher T-Hg levels (7.34 μg/L) compared to the control group (2.01 μg/L), surpassing the accepted limit. Moreover, the study group showed a higher incidence of DNA damage and cell death biomarkers (p < 0.05). Additionally, significant correlations were observed between total blood Hg levels and the frequencies of micronuclei, karyorrhexis, and karyolysis.</p><p><strong>Conclusion: </strong>These results suggest that island populations of Cartagena are exposed to high levels of Hg and exhibit genotoxic damage, indicating a problem that must be addressed.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"946"},"PeriodicalIF":0.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11747300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influencing factors of health-related quality-of-life perceived by both children/adolescents patients with type-1 diabetes mellitus and their parents: A North-African study.","authors":"Imen Ben Abdesselem, Raoudha Kebeili, Khansa Derbel, Hichem Ben Said, Lamia Boughamoura, Jihene Bouguila, Helmi Ben Saad","doi":"10.12688/f1000research.148074.1","DOIUrl":"10.12688/f1000research.148074.1","url":null,"abstract":"<p><strong>Aim: </strong>To determine the influencing factors of health-related quality-of-life (HRQoL) perceived by North-African children/adolescents with type-1 diabetes-mellitus (T1DM) and their parents.</p><p><strong>Methods: </strong>It was a cross sectional study conducted in Tunisia. A total of 116 patients ( <b><i>ie</i></b> ; 43 children and 73 adolescents) and their parents were included. The Arabic validated version of the Pediatric Generic Core Quality-of-Life Inventory 4.0-Scale (PedsQL4.0) was used to evaluate the HRQoL of children/adolescents as perceived by patients and parents. The dependent data were the patients' self-report and the parents' proxy-report of the PedsQL4.0 total scores, and the independent data were the patients and parents characteristics.</p><p><strong>Results: </strong>Patients' PedsQL4.0 total score was influenced significantly by siblings in the family > 2; lipodystrophy, and glycosylated hemoglobin (HbA1C). The combination of these factors explained 34.84% of the PedsQL4.0 total score variability. Parents' PedsQL4.0 total score was influenced significantly by lipodystrophy, siblings; body mass index (BMI), hypoglycemia episodes, and HbA1C. The combination of these factors explained 56.92% of the PedsQL4.0 total score variability.</p><p><strong>Conclusion: </strong>T1DM patients self-reported HRQoL was influenced by siblings in the family > 2; lipodystrophy, and HbA1C. The parents' proxy-report HRQoL was influenced by lipodystrophy, siblings, BMI, hypoglycemia episodes, and HbA1C.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"429"},"PeriodicalIF":0.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic and Prognostic Values of miRNAs in High-Grade Gliomas: A Systematic Review.","authors":"Renindra Ananda Aman, Mohammad Galih Pratama, Ricky Rusydi Satriawan, Irfani Ryan Ardiansyah, I Ketut Agus Suanjaya","doi":"10.12688/f1000research.151350.2","DOIUrl":"10.12688/f1000research.151350.2","url":null,"abstract":"<p><strong>Background: </strong>Gliomas, particularly glioblastomas, have grim prognoses, necessitating early diagnostic and prognostic indicators. MicroRNAs (miRNAs), influential in cancer research, show potential as glioma biomarkers. This systematic review aimed to examine the efficacy of miRNAs in the diagnosis and prognosis of high-grade glioma.</p><p><strong>Methods: </strong>A comprehensive search was conducted of PubMed, EMBASE, Cochrane Library, and Web of Science for studies published from 2013 to 2023. The eligibility criteria included high-grade glioma, histopathological confirmation, miRNA samples from cerebrospinal fluid or plasma, and relevant outcome data. Studies were excluded if they were experimental or reviews and not in English.</p><p><strong>Results: </strong>Of the 1120 initial results, 8 studies involving 660 subjects met the inclusion criteria. Several studies have assessed miRNA expression and its association with diagnosis and prognosis of high-grade gliomas. Overexpression of miR-221, miR-222, miR-210, miR-21, miR-125b, and miR-223 and under-expression of miR-15b and miR-124-3p showed significant potential in differentiating high-grade glioma patients from controls. Additionally, miRNAs are associated with distinct tumorigenic pathways.</p><p><strong>Conclusion: </strong>Elevated or depressed expression levels of specific circulating miRNAs hold significant promise as noninvasive biomarkers for the diagnosis and prognosis of high-grade glioma. These miRNAs offer valuable insights into disease progression and patient outcome. Further validation through extensive clinical trials and in-depth mechanistic studies is essential to realize their full clinical utility.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"796"},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11826073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CYP2C19 polymorphism and coronary in-stent restenosis: A systematic review and meta-analysis.","authors":"Yusra Pintaningrum, Vitriyaturrida, Ivana Purnama Dewi, Hendy Bhaskara Perdana Putra, Idar Mappangara, Muzakkir Amir, Irawan Yusuf, Agussalim Bukhari","doi":"10.12688/f1000research.109321.2","DOIUrl":"10.12688/f1000research.109321.2","url":null,"abstract":"<p><strong>Background: </strong>In-stent restenosis (ISR) remains a major drawback in coronary stenting. The association between the CYP2C19 loss of function (LOF) gene and the prevalence of ISR after coronary stenting remains controversial. Previous studies have produced conflicting results and have been limited by their small population sizes. We conducted this systematic review and meta-analysis to determine the association between the presence of the CYP2C19 LOF gene and the prevalence of ISR.</p><p><strong>Methods: </strong>A systematic online database search was performed until April 2021. The primary outcome was ISR and assessed using OR with 95% CI. Quality of the study was assessed using the Newcastle Ottawa Scale. <i>I ²</i> was applied to examine heterogeneities among the studies.</p><p><strong>Results: </strong>A total of 284 patients (four non-randomized controlled trial studies) were included in this study. Two hundred and six patients had wild-type genotypes, while 78 patients had the LOF genotype. Among the 78 patients with the LOF gene, 38 patients had an ISR. Meanwhile, of the 206 patients with a wild-type gene, 69 patients had an ISR. LOF gene was associated with a higher risk of ISR (OR 95% CI = 2.71 [1.42-5.16], P = 0.003). However, study-specific variability should be considered when applying these findings clinically.</p><p><strong>Conclusions: </strong>Patients with LOF genes, regardless of the allele variation, treated with clopidogrel, had a higher likelihood of ISR after coronary stenting.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"11 ","pages":"346"},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11078198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140893179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alternative dispute resolution: Mediation as a model.","authors":"Naser Sherman, Bashar Talal Momani","doi":"10.12688/f1000research.152362.2","DOIUrl":"https://doi.org/10.12688/f1000research.152362.2","url":null,"abstract":"<p><strong>Background: </strong>The topic of Alternative Dispute Resolution (ADR) in civil and commercial contexts presents a contemporary legal challenge aimed at fostering equitable solutions. Among ADR methods, mediation stands out for its ability to reduce time, costs, and litigation duration. This study explores the conceptual framework, essential conditions, and procedural aspects of mediation. It evaluates the sufficiency, regulation, and effectiveness of mediation principles in conflict resolution and risk mitigation.</p><p><strong>Methods: </strong>This study is conducted through a comprehensive review of current literature on Alternative Dispute Resolution methods, with a particular focus on mediation as an alternative to dispute settlement. The study utilizes qualitative analysis techniques to examine the effectiveness of mediation principles and their application in resolving civil and commercial disputes. Comparative analyses are also conducted to extract useful insights from various legal systems and authorities.</p><p><strong>Results: </strong>The study provides an analysis that illustrates the effectiveness of mediation in resolving disputes, emphasizing its potential benefits in terms of time and cost savings, as well as its srole in facilitating amicable resolutions. The results of this study shall contribute to the current body of knowledge on mediation and provide practical recommendations for its application in diverse legal contexts.</p><p><strong>Conclusion: </strong>In conclusion, the study proposes strategies to enhance mediation practices, promote a culture of its adoption, and integrate it more closely into the judicial system. Additionally, it anticipates the future effectiveness of mediation in jurisdictions lacking comprehensive legislation, drawing from successful Western experiences to guide potential developments in Arab legal frameworks.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"778"},"PeriodicalIF":0.0,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11806251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuronal subset-specific <i>Pten</i>-deficient mice do not exhibit deficits in sensorimotor gating processes.","authors":"Matthew S Binder, Suzanne O Nolan, Joaquin N Lugo","doi":"10.12688/f1000research.20604.3","DOIUrl":"10.12688/f1000research.20604.3","url":null,"abstract":"<p><strong>Background: </strong>Deficits in sensorimotor gating have been reported in individuals with autism spectrum disorder (ASD), as well as in ASD murine models. However, this behavior has not been examined in the neuronal subset-specific (NS)- <i>Pten</i> knockout (KO) model of ASD. <i>NS-Pten</i> KO mice exhibit hyperactivity of the PI3K/AKT/mTOR signaling pathway which is implicated in the onset of autistic deficits. This study investigates the potential relationship between PI3K/AKT/mTOR signaling and deficits in sensorimotor gating.</p><p><strong>Methods: </strong>To assess sensorimotor gating in NS- <i>Pten</i> KO mice we utilized a three-day paradigm. On day 1 (habituation) the mice were administered 80 repetitions of a 120-dB startle stimulus. On day 2, prepulse inhibition was measured with 90 trials of the startle stimulus that was paired with a smaller (2, 7, or 12 dB) prepulse stimulus. Day 3 was assessed one week later, consisting of randomized startle trials and trials with no stimulus and was used to determine the startle response.</p><p><strong>Results: </strong>No significant difference between NS- <i>Pten</i> KO or wildtype (WT) mice was found for habituation ( <i>p</i> > 0.05). No significant differences were found between groups when assessing the percentage of prepulse inhibition at 2, 7, and 12 dB ( <i>p</i> > 0.05). There was also no difference in startle response between groups ( <i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>Our study found that the NS- <i>Pten</i> KO model does not display significant deficits in sensorimotor gating processes. The present findings help to elucidate the relationship between PI3K/AKT/mTOR hyperactivation and sensory reactivity.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"8 ","pages":"1727"},"PeriodicalIF":0.0,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conditioning factors for the scientific productivity of undergraduate students of health sciences at a private Peruvian University: A cross-sectional analytical study.","authors":"César Antonio Bonilla-Asalde, Isabel Cristina Rivera-Lozada, Oriana Rivera-Lozada","doi":"10.12688/f1000research.143021.2","DOIUrl":"10.12688/f1000research.143021.2","url":null,"abstract":"<p><strong>Background: </strong>The objective of this study was to determine the conditioning factors for scientific research productivity in university students of health sciences.Scientific productivity, in addition to making visible the generation of new knowledge, contributes to the well-being of the population and provides feedback to the scientific community in terms of methodologies, perspectives and results that help to break down barriers that delimit productivity in scientific research.</p><p><strong>Methods: </strong>A cross-sectional analytical observational study was conducted. The study population was 4104 students enrolled during the 2021-I semester in the Faculty of Health Sciences of a private Peruvian university. A sample size of 400 students was determined and a stratified probability sampling was used. The variables were measured through surveys. The dependent variable was scientific research productivity, and the independent variables were institutional culture, knowledge management and technological capital. Summary measures are reported according to the type of variable. The chi-square test with a significance level of p<0.05 was applied to assess the association between the variables of interest. A multiple logistic regression analysis was performed using the Stepwise method. Prevalence ratios (PR) with their respective 95% confidence intervals (95%CI) were calculated.</p><p><strong>Results: </strong>From the total of 400 students, 74.5% were male, 57.25% were aged between 18 and 27 years, 17% belonged to the school of human medicine and 72% were in their sixth year of studies. Scientific research productivity was associated with management commitment (PR=1.493; 95%CI: 1.077-2.068, p=0.015), sense of personal growth (PR=1.632; 95%CI: 1.041-2.558; p=0.024), recognition by the university (PR=1.385; 95%CI: 1.012-1.896; p=0.043), strategic alliances (PR=1.422; 95%CI: 1.032-1.959; p=0. 03), having research proposals (PR=1.522; 95%CI: 1.114-2.08; p=0.009), dissemination of results obtained (PR=1.542; 95%CI: 1.12-2.122; p=0.01), availability of human resources (PR=1.591; 95%CI: 1.165-2.173; p=0.004), access to equipment and software (PR=1.482; 95%CI: 1.061-2.069; p=0.018) and to laboratories (PR=1.438; 95%CI: 1.047-1.974; p=0.024).</p><p><strong>Conclusion: </strong>It is concluded that the research productivity of undergraduate students of health sciences is low. It is imperative to strengthen the university research culture that empowers students as agents of change and strengthens faculty participation in scientific networks and communities.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"5"},"PeriodicalIF":0.0,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}