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Community preparedness for earthquake disasters: A preliminary assessment of awareness and disaster infrastructure response in Cianjur, West Java-Indonesia.
F1000Research Pub Date : 2025-02-20 eCollection Date: 2024-01-01 DOI: 10.12688/f1000research.143577.3
Dewayany Sutrisno, Yatin Suwarno, Ati Rahadiati, Muhammad Iqbal Habibie, Prabu Kresna Putra, Hari Prayogi, Amien Widodo, Fathia Zulfati Sabrina, Ahmad Kosasih
{"title":"Community preparedness for earthquake disasters: A preliminary assessment of awareness and disaster infrastructure response in Cianjur, West Java-Indonesia.","authors":"Dewayany Sutrisno, Yatin Suwarno, Ati Rahadiati, Muhammad Iqbal Habibie, Prabu Kresna Putra, Hari Prayogi, Amien Widodo, Fathia Zulfati Sabrina, Ahmad Kosasih","doi":"10.12688/f1000research.143577.3","DOIUrl":"10.12688/f1000research.143577.3","url":null,"abstract":"<p><strong>Background: </strong>The danger of earthquakes poses a serious threat to people worldwide. One of the most significant challenges is preparing communities to cope effectively with this disaster. Therefore, understanding earthquake hazards is critically important for preparedness, mitigation, and an effective response to this threat. This report aims to observe and conduct a preliminary assessment of the degree to which community preparedness for earthquake disasters has been implemented.</p><p><strong>Methods: </strong>Empirical data were obtained from survey respondents and interviews. The respondents were members of a community affected by the Cianjur earthquake, which occurred on November 21, 2022. The data were analysed using the mean range approach, based on Likert scales. Additionally, the Spearman correlation method was employed to indicate the relationship between community awareness and infrastructure readiness.</p><p><strong>Result: </strong>Based on empirical evidence and preliminary analysis, it is evident that the preparedness of the community to respond effectively to earthquake catastrophes is inadequate. An apparent lack of readiness is observed in the inadequate construction of housing that fails to meet disaster standards, and the absence of disaster response facilities is notable.</p><p><strong>Conclusions: </strong>Based on our initial assumption, it appears that knowledge related to disaster resilience in this area has not been adequately disseminated or socialized. However, this premise requires further investigation.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"256"},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Through restful waters and deep commotion: A study on burnout and health impairment of Italian seafarers from the JD-R model perspective.
F1000Research Pub Date : 2025-02-20 eCollection Date: 2025-01-01 DOI: 10.12688/f1000research.159198.1
Francesco Buscema, Lorenzo Cena, Clarissa Cricenti, Margherita Zito, Lara Bertola, Lara Colombo
{"title":"Through restful waters and deep commotion: A study on burnout and health impairment of Italian seafarers from the JD-R model perspective.","authors":"Francesco Buscema, Lorenzo Cena, Clarissa Cricenti, Margherita Zito, Lara Bertola, Lara Colombo","doi":"10.12688/f1000research.159198.1","DOIUrl":"10.12688/f1000research.159198.1","url":null,"abstract":"<p><strong>Background: </strong>The work experience of seafarers differs significantly from other land-based occupations due to several factors, particularly remoteness and the restricted work environment. This study seeks to examine the impact of burnout and health impairment in the maritime industry, using the Job Demand-Resources theory as a framework.</p><p><strong>Methods: </strong>To investigate these phenomena, an online questionnaire was sent to 629 Italian seafarers and we conducted analysis on a valid sample of 239 respondents (94.6% men, Mage = 39.44, SD = 12.8). We tested a mediated Structural Equation Model (SEM) aimed at predicting negative health outcomes.</p><p><strong>Results: </strong>The results show that burnout plays a mediating role between job demands (such as workload and cognitive strain) and health impairment (such as sleep quality and physical well-being) (Total Indirect Effect = 0.443, <i>p</i> < .0001) as well as between job resources (such as social support and transformational leadership) and health impairment (Total Indirect Effect = -0.249, <i>p</i> < .0001). Furthermore, the findings highlight the direct influence of occupational resources on seafarers' health.</p><p><strong>Conclusions: </strong>The discussion highlights the urgent need for more research in the field of organisational psychology in the maritime industry and the discrepancies between these findings, which are consistent with the existing maritime literature, and other studies that do not include seafarers in their sample groups.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"19"},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11751612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Magnitude and Factors Associated with Research Misconduct at a Public University in Ethiopia: A Cross-Sectional Survey.
F1000Research Pub Date : 2025-02-20 eCollection Date: 2025-01-01 DOI: 10.12688/f1000research.159997.2
Habtamu Belay Hailu, Telahun Teka Wolde, Betselot Yirsaw Wubete, Joseph Ali, Sintayehu Tsegaye Bitew
{"title":"Magnitude and Factors Associated with Research Misconduct at a Public University in Ethiopia: A Cross-Sectional Survey.","authors":"Habtamu Belay Hailu, Telahun Teka Wolde, Betselot Yirsaw Wubete, Joseph Ali, Sintayehu Tsegaye Bitew","doi":"10.12688/f1000research.159997.2","DOIUrl":"10.12688/f1000research.159997.2","url":null,"abstract":"<p><strong>Background: </strong>Research integrity, essential for ethical scientific research, has been inadequately addressed in Ethiopia, resulting in gaps in addressing misconduct like plagiarism, falsification and fabrication. The aim of this study was to assess the magnitude and factors associated with research misconduct at a public university in Ethiopia.</p><p><strong>Methods: </strong>An institutional-based cross-sectional study was conducted on a random sample of researchers. Data were collected via a self-administered, structured questionnaire, which was adapted from a similar study. The collected data were analysed using descriptive, bivariate, and multivariable logistic regression.</p><p><strong>Result: </strong>A total of 244 researchers participated in the study, resulting in an 82% response rate. In our study, 37.7% of participants reported engaging in at least one form of misconduct, 95% CI [31.6%, 44.1%]. Authorship misconduct was the most common form of self-reported misconduct (47.5%), 95% CI [41.1%, 54.0%], followed by fabrication and falsification (40.6%), 95% CI [34.4%, 47.0%]. Publication pressure was significantly associated with research misconduct (AOR = 3.18; 95% CI: [1.02, 9.95]).</p><p><strong>Conclusion: </strong>This study highlights the prevalence of research misconduct and questionable research practices among academic researchers, with authorship misconduct, fabrication, falsification, and plagiarism being the most commonly reported types. Attitudes toward research misconduct and self-reported involvement were influenced by academic position, research experience, and publication pressure, with junior researchers being more likely to report engaging in misbehavior. While ethics training has occasionally been associated with reduced rates of research misconduct, its effectiveness remains uncertain, as institutional culture, supervision, and mentorship may play a more significant role. Addressing research misconduct requires a comprehensive approach that extends beyond ethical instruction, incorporating targeted support for early-career researchers, open dialogue, and institutional policy reforms.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"111"},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Value of Applying Big Data Analytics in Health Supply Chain Management.
F1000Research Pub Date : 2025-02-19 eCollection Date: 2024-01-01 DOI: 10.12688/f1000research.156525.4
Dina Al Nuaimi, Niyi Awofeso
{"title":"The Value of Applying Big Data Analytics in Health Supply Chain Management.","authors":"Dina Al Nuaimi, Niyi Awofeso","doi":"10.12688/f1000research.156525.4","DOIUrl":"10.12688/f1000research.156525.4","url":null,"abstract":"<p><p>This study aims to evaluate the impact of big data analytics (BDA) on the performance of healthcare supply chain management (HCSCMP) by examining both overall efficiency improvements and identifying critical success factors for effective implementation. Through a systematic literature review, the research investigates how BDA enhances real-time decision-making within healthcare supply chains (HCSCs) and identifies the key enablers required for successful BDA adoption. A comprehensive search strategy was employed to analyze 65 papers, resulting in the inclusion of 39 studies published between 2016 and 2023. The review revealed a preference for literature reviews and questionnaires as the primary research methods. The findings indicate that BDA significantly improves HCSCs' efficiency, particularly in real-time decision-making and operational management. However, successful BDA implementation depends on addressing critical enablers and overcoming associated challenges.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1237"},"PeriodicalIF":0.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11842960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Examining the effects of anxiety and education level on mental health: The role of spiritual intelligence as an intervening variable in post COVID-19 patients in Indonesia.
F1000Research Pub Date : 2025-02-18 eCollection Date: 2024-01-01 DOI: 10.12688/f1000research.154599.3
Anis Ansyori, Ahmad Yunus, Sentot Imam, Yuly Peristiowati
{"title":"Examining the effects of anxiety and education level on mental health: The role of spiritual intelligence as an intervening variable in post COVID-19 patients in Indonesia.","authors":"Anis Ansyori, Ahmad Yunus, Sentot Imam, Yuly Peristiowati","doi":"10.12688/f1000research.154599.3","DOIUrl":"10.12688/f1000research.154599.3","url":null,"abstract":"<p><strong>Background: </strong>The COVID-19 pandemic has profoundly affected global health systems and daily life, exacerbating vulnerabilities, particularly in Indonesia. This study investigates the impact of anxiety and education level on mental health, with spiritual intelligence as an intervening variable among post-COVID-19 patients in Indonesia.</p><p><strong>Methods: </strong>Utilizing a cross-sectional design, data were collected from 390 post-COVID-19 patients in Indonesia. Structured questionnaires assessed anxiety, education level, spiritual intelligence, and mental health. Structural Equation Modeling (SEM) was used to analyze the relationships among these variables.</p><p><strong>Results: </strong>The findings indicate that anxiety significantly affects both spiritual intelligence and mental health, with spiritual intelligence acting as a mediating factor. Additionally, higher educational attainment is positively associated with enhanced spiritual intelligence and improved mental health outcomes.</p><p><strong>Conclusions: </strong>The study underscores the importance of incorporating spiritual development practices into mental health interventions and educational programs to boost resilience and overall well-being in the post-pandemic era. While these findings are promising, the cross-sectional design limits causal inferences, and future research should consider longitudinal studies to examine these relationships over time. These practices can help mitigate the adverse effects of anxiety and educational disparities on mental health.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"916"},"PeriodicalIF":0.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11826076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The macroeconomic determinants of trade openness in Latin American countries: A panel data analysis. 拉丁美洲国家贸易开放的宏观经济决定因素:面板数据分析
F1000Research Pub Date : 2025-02-17 eCollection Date: 2024-01-01 DOI: 10.12688/f1000research.153690.3
Rogger Orlando Morán Santamaría, Yefferson Llonto Caicedo, Francisco Eduardo Cúneo Fernández, Lizana Guevara Nikolays Pedro, Castro Mejía Percy Junior, Milagros Judith Pérez Pérez, Lindon Vela Meléndez, Moises Elias Montenegro López
{"title":"The macroeconomic determinants of trade openness in Latin American countries: A panel data analysis.","authors":"Rogger Orlando Morán Santamaría, Yefferson Llonto Caicedo, Francisco Eduardo Cúneo Fernández, Lizana Guevara Nikolays Pedro, Castro Mejía Percy Junior, Milagros Judith Pérez Pérez, Lindon Vela Meléndez, Moises Elias Montenegro López","doi":"10.12688/f1000research.153690.3","DOIUrl":"10.12688/f1000research.153690.3","url":null,"abstract":"<p><strong>Background: </strong>Trade openness shows a positive impact on economic growth, supported by economic theory, and export diversification and economic complexity show a positive dynamic in trade openness in the world; however, a specificity is generated in South American countries. Therefore, the objective of the research is to analyse the macroeconomic determinants of trade openness in Latin American countries.</p><p><strong>Methods: </strong>The research approach was quantitative and explanatory using panel data methodology from the databases of the World Bank, Harvard University and the Economic Commission for Latin America and the Caribbean for the period 2000-2020.</p><p><strong>Results: </strong>The fixed effects panel data model showed that the variables that had a negative impact on trade openness were GDP, the economic complexity index and the logistic performance index, while the variables that had a positive impact were exports of high-tech products (a proxy for innovation), exports, imports, research and development expenditure and interregional trade in goods.</p><p><strong>Conclusions: </strong>Therefore, during the analysis period of 2000-2020 in South America, based on the panel data analysis under fixed effects, a total of 8 countries had a negative impact on trade openness, and only the economies of Chile, French Guiana, and Brazil had a positive impact on trade openness; these economies are characterized by their better performance in the economic complexity index, their higher percentage of budget for research and development expenses, and their trade policies oriented towards the industrialization of their value-added products.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"958"},"PeriodicalIF":0.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11842959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiological, Gross Morphological, And Histopathological Analysis Of Postmortem Cases Of Hanging - An Observational Study.
F1000Research Pub Date : 2025-02-17 eCollection Date: 2024-01-01 DOI: 10.12688/f1000research.159606.2
Alana Chacko, Chandni Gupta, Vikram Palimar, Deepak Nayak M
{"title":"Epidemiological, Gross Morphological, And Histopathological Analysis Of Postmortem Cases Of Hanging - An Observational Study.","authors":"Alana Chacko, Chandni Gupta, Vikram Palimar, Deepak Nayak M","doi":"10.12688/f1000research.159606.2","DOIUrl":"10.12688/f1000research.159606.2","url":null,"abstract":"<p><strong>Background: </strong>Death due to hanging is commonly seen. Sometime the ligature mark will be very prominent and in some cases it might not. In those cases, the post-mortem examination with its gross morphological findings and histopathological analysis, becomes significantly important. Objective: The objective of this study was to identify the patterns of epidemiological, gross morphological, and histopathological features in hanging cases.</p><p><strong>Methods: </strong>The study was conducted on 46 cases of hanging and was carried out from February 2023 to June 2024. Their sociodemographic features were collected. Gross morphological analysis of the ligature mark and various measurements were taken. Later tissue from the ligature mark was sent for histopathological analysis. Statistical analysis was performed on the collected parameters.</p><p><strong>Results: </strong>Significant male preponderance was observed in hanging cases. The maximum number of cases of hanging were observed in the fourth decade of life. Daily wage workers were the most significantly affected population. Depression was cited as the cause of suicide in most cases. Carotid intimal tears and injuries to bony and cartilaginous structures were present in smaller numbers. Vital reaction was observed in all 46 cases. Classification of wound vitality showed a correlation to known time since injury.</p><p><strong>Conclusion: </strong>The results of the present study showed that socio-demographic factors play a significant role in the circumstances leading to suicidal deaths. Therefore, in reducing the burden of suicidal deaths, these factors must be addressed. To identify the cause of death as hanging analysis of various gross features and histopathology are very important and should be conducted carefully.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1556"},"PeriodicalIF":0.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Obtaining a PhD in Portugal. Determinants of Success and Subsequent Career Paths.
F1000Research Pub Date : 2025-02-17 eCollection Date: 2024-01-01 DOI: 10.12688/f1000research.150552.2
Ana Ramos, Daniel Ferreira
{"title":"Obtaining a PhD in Portugal. Determinants of Success and Subsequent Career Paths.","authors":"Ana Ramos, Daniel Ferreira","doi":"10.12688/f1000research.150552.2","DOIUrl":"10.12688/f1000research.150552.2","url":null,"abstract":"<p><strong>Background: </strong>Over the past three decades, Portugal has invested significantly in doctoral training. However, there is a lack of up-to-date information on the success of scholarship holders in obtaining the degree or on their subsequent career paths.</p><p><strong>Methods: </strong>This study analysed four cohorts of scholarship holders funded by the Foundation for Science and Technology between 1995 and 2012. The professional situation at different points in time after the Ph.D. (5, 10, 15 and 20 years) was studied.</p><p><strong>Results: </strong>The success rate for obtaining the degree was 88%, which is comparable to other European countries for doctorates completed with funding over a period of 3-4 years. The average time to obtain the degree was 5.06 years. The time to degree was influenced by the scientific field, the nationality of the scholarship holder, and the location of the institution awarding the degree (in Portugal or abroad). The gender or age range of the scholarship recipients did not influence the time required for graduation.The analysis of the career and sector of activity of these graduates at different points in time after obtaining the Ph.D. revealed that approximately 60% percent of the graduates were engaged in R&D activities at some point in their career paths, but this percentage diminished from the oldest to the most recent cohorts. In 2020, 63% of the graduates were engaged in R&D activities, and almost half were employed in higher education as teachers, researchers, or scholarship holders.</p><p><strong>Conclusions: </strong>This study showed that there are still challenges to address concerning the integration of doctoral graduates into non-academic research positions. On the other hand, it has demonstrated an efficient use of public funds, with high success rates and a time to degree that is within the average of other European countries.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1101"},"PeriodicalIF":0.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11914870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cicada minimum age tree: Cryptic speciation and exponentially increasing base substitution rates in recent geologic time. 蝉的最小年龄树:最近地质年代的隐性物种和指数级增长的碱基替换率。
F1000Research Pub Date : 2025-02-14 eCollection Date: 2022-01-01 DOI: 10.12688/f1000research.76068.4
Soichi Osozawa, John Wakabayashi
{"title":"Cicada minimum age tree: Cryptic speciation and exponentially increasing base substitution rates in recent geologic time.","authors":"Soichi Osozawa, John Wakabayashi","doi":"10.12688/f1000research.76068.4","DOIUrl":"10.12688/f1000research.76068.4","url":null,"abstract":"<p><p>We developed a new time-calibrated phylogenetic tree incorporating primarily endemic Ryukyu Islands cicada data, along with some cryptic species, following the recent global cicada studies by Marshall <i>et al.</i> (2018), Łukasik <i>et al.</i> (2018), Simon <i>et al.</i> (2019), Price <i>et al.</i> (2019), and Hill <i>et al.</i> (2021). A total of 352 specimens were analyzed using BEAST v1.10.4 software with a relaxed clock model. Fossil calibrations dating as far back as the Triassic were adopted, largely following Johnson <i>et al.</i> (2018) and Moulds (2018), with a Quaternary geological event calibration based on Osozawa <i>et al.</i> (2012, 2021b), which was input into BEAST v1.10.4. In the COI tree, the crown age of Cicadoidea was estimated at 200.63 Ma. Tettigarctidae was found to be the oldest lineage, sister to all remaining cicadas. Derotettiginae, at 99.2 Ma, is the next oldest lineage, sister to all other monophyletic cicadas. The Tibicininae clade branched at 66.15 Ma, with the subfamilies Tettigomyiinae, Cicadettinae, and Cicadidae diverging at a crown age of 40.57 Ma. The Cicadinae clade consists of many tribe and genus-specific clades, with numerous cryptic species emerging due to vicariance and adaptive radiation. We estimated the base substitution rate as a function of age, and the results strongly indicate an exponential increase in substitution rates during recent geological time. This increase in cicada biodiversity, including the generation of cryptic species in the Ryukyu Islands and surrounding regions, may have been driven by the spread of C4 grasses and concurrent Quaternary climate changes.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"11 ","pages":"308"},"PeriodicalIF":0.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11564946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combined exosome of adipose-derived mesenchymal stem cell and hyaluronic acid delays early osteoarthritis progression of ovine sheep model: Clinical, radiographic, macroscopic and microscopic evaluation.
F1000Research Pub Date : 2025-02-13 eCollection Date: 2024-01-01 DOI: 10.12688/f1000research.147309.2
Ludwig Andribert Powantia Pontoh, Jessica Fiolin, Ismail Hadisoebroto Dilogo, Marcel Prasetyo, Radiana Dhewayani Antarianto, Alida Harahap, Angela Jennifer Tantry, Trevino Aristakus Pakasi, Bambang Pontjo Priosoeryanto, Tri Isyani Tungga Dewi
{"title":"Combined exosome of adipose-derived mesenchymal stem cell and hyaluronic acid delays early osteoarthritis progression of ovine sheep model: Clinical, radiographic, macroscopic and microscopic evaluation.","authors":"Ludwig Andribert Powantia Pontoh, Jessica Fiolin, Ismail Hadisoebroto Dilogo, Marcel Prasetyo, Radiana Dhewayani Antarianto, Alida Harahap, Angela Jennifer Tantry, Trevino Aristakus Pakasi, Bambang Pontjo Priosoeryanto, Tri Isyani Tungga Dewi","doi":"10.12688/f1000research.147309.2","DOIUrl":"10.12688/f1000research.147309.2","url":null,"abstract":"<p><strong>Background: </strong>Current treatment of osteoarthritis (OA) mainly focused on treating symptoms. Exosome from Adipose-derived Mesenchymal Stem Cell (Ad-MSC) have been shown to delay degenerative process. This study aimed to investigate the clinical, radiological and histological impact of combined intra-articular (IA) hyaluronic acid (HA) and exosome Ad-MSCs in-vivo using a larger animal model with low-grade OA.</p><p><strong>Methods: </strong>Eighteen male <i>Ovies aries</i> sheep underwent total lateral meniscectomy and conventional radiography was performed to confirm low-grade OA after 6 weeks. The sheep were divided into three groups, Group 1 (G1; n=6) received thrice exosome injections, G2 (n=6) received twice HA injection, and G3 (n=6) received both treatments with a 1-week interval after 10 days of meniscectomy. Clinical evaluations were conducted using the Clinical Lameness Score (CLS), radiographic with X-ray using OA score by Innes et al, while macroscopic evaluation by Osteoarthritis Research Society International (OARSI) scores.</p><p><strong>Results: </strong>Lameness parameter scored lowest in G3 significantly (2.0±0.0 VS 2.7±0.52 VS 2.7±0.52; p=0.024) at the second month although the overall CLS score did not significantly differ at the 3 <sup>rd</sup> month. The best improvement of conventional total OA radiographic score at the 3 <sup>rd</sup> month compared to all groups (5.2±1.17 vs 6.3±0.82 vs 6.7±1.03; p=0.053). Macroscopic OARSI evaluation showed no difference (p=0.711).</p><p><strong>Conclusions: </strong>Combined repeated exosome Ad-MSC and HA IA injection proven to delay OA progression, however longer duration of follow up is required to evaluate its long-term effect.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"494"},"PeriodicalIF":0.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11842963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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