F1000Research最新文献

{"title":"Exploring needs, perceptions, and preferences towards exercise video among overweight individuals - a qualitative study.","authors":"Shishira K B, K Vaishali, Rajagopal Kadavigere, Suresh Sukumar, Tulasiram Bommasamudram, Praveen Hoogar","doi":"10.12688/f1000research.150772.3","DOIUrl":"https://doi.org/10.12688/f1000research.150772.3","url":null,"abstract":"<p><strong>Background: </strong>The number of overweight people (BMI 25-29.9kg.m ^-2) in the world is increasing, which increases the risk of health problems and psychological difficulties. To reduce these risks, it is imperative to address unhealthy habits including food and exercise. This qualitative study aimed to explore the needs, perceptions, and preferences of overweight individuals on tailored exercise programs that incorporate educational videos.</p><p><strong>Methodology: </strong>Forty Individuals between the age of 18-30 years with a BMI of 25-29.9kg.m ^-2 were included in the study using Purposive sampling from October 2023 to November 2023. Semi-structured in-depth interview was conducted for 45-60 minutes approximately among both active and inactive overweight individuals by a researcher trained in qualitative research. These interviews were audio-recorded and transcribed verbatim. Thematic analysis was performed using inductive and deductive approaches to identify the recurrent patterns, themes, and insights in the transcribed interviews.</p><p><strong>Results: </strong>8 themes, such as lifestyle factors, exercise explorations, holistic wellbeing and 44 subthemes emerged from the analysis, helping to shed light on the needs, perceptions, and preferences that overweight individuals experience when it comes to their preference for a customized exercise program provided through educational video. The participants wanted personalized regimens that catered to their requirements and levels of fitness.</p><p><strong>Conclusion: </strong>In summary, the findings emphasize the value of educational videos that are easy to use, visually appealing, and supported by science. These videos should emphasize technique, varying levels of difficulty, and brief sessions.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"998"},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantized Convolutional Neural Networks Robustness under Perturbation.","authors":"Jack Langille, Issam Hammad, Guy Kember","doi":"10.12688/f1000research.163144.1","DOIUrl":"https://doi.org/10.12688/f1000research.163144.1","url":null,"abstract":"<p><p>Contemporary machine learning models are increasingly becoming restricted by size and subsequent operations per forward pass, demanding increasing compute requirements. Quantization has emerged as a convenient approach to addressing this, in which weights and activations are mapped from their conventionally used floating-point 32-bit numeric representations to lower precision integers. This process introduces significant reductions in inference time and simplifies the hardware requirements. It is a well-studied result that the performance of such reduced precision models is congruent with their floating-point counterparts. However, there is a lack of literature that addresses the performance of quantized models in a perturbed input space, as is common when stress testing regular full-precision models, particularly for real-world deployments. We focus on addressing this gap in the context of 8-bit quantized convolutional neural networks (CNNs). We study three state-of-the-art CNNs: ResNet-18, VGG-16, and SqueezeNet1_1, and subject their floating point and fixed point forms to various noise regimes with varying intensities. We characterize performance in terms of traditional metrics, including top-1 and top-5 accuracy, as well as the F1 score. We also introduce a new metric, the Kullback-Liebler divergence of the two output distributions for a given floating-point/fixed-point model pair, as a means to examine how the model's output distribution has changed as a result of quantization, which, we contend, can be interpreted as a proxy for model similarity in decision making. We find that across all three models and under each perturbation scheme, the relative error between the quantized and full-precision model was consistently low. We also find that Kullback-Liebler divergence was on the same order of magnitude as the unperturbed tests across all perturbation regimes except Brownian noise, where significant divergences were observed for VGG-16 and SqueezeNet1_1.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"419"},"PeriodicalIF":0.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of sub-maximal aerobic capacity in North African patients with chronic hepatitis B: a pilot case-control study.","authors":"Jihene Bergaoui, Imed Latiri, Sawssen Mrad, Houda Chaouch, Salma Amous, Jihene Ben Abdallah, Samia Ernez Hajri, Helmi Ben Saad","doi":"10.12688/f1000research.160390.1","DOIUrl":"https://doi.org/10.12688/f1000research.160390.1","url":null,"abstract":"<p><strong>Background: </strong>Studies assessing sub-maximal aerobic capacity in non-cirrhotic chronic hepatitis B (CHB) patients are scarce. This study aimed to evaluate sub-maximal aerobic capacity in CHB patients compared to apparently healthy participants (control-group (CG)).</p><p><strong>Methods: </strong>A 6-min walk test (6MWT) was performed. The 6-min walk distance (6MWD) was recorded, along with heart-rate (HR), oxy-hemoglobin saturation (SpO ₂), blood-pressure, and dyspnea ( <b><i>ie</i></b> ; visual analogue scale) at rest (Rest) and at the end (End) of the 6MWT. Additionally, the 6-min walk work (6MWW), and estimated cardiorespiratory and muscular chain age were calculated. Signs of physical intolerance were determined including abnormal 6MWD ( <b><i>ie</i></b> ; 6MWD < lower limit of normal), chronotropic insufficiency (ie ; HREnd < 60% of maximal predicted HR (MPHR)), high dyspnea ( <b><i>ie</i></b> ; dyspneaEnd > 5), and desaturation ( <b><i>ie</i></b> ; drop in SpO ₂ > 5 points).</p><p><strong>Results: </strong>Compared to the CG (n=28), the CHB-group (n=26) exhibited significantly lower 6MWD by 61 meters (8%), lower 6MWW by 10%, and lower HR _End by 21% (when expressed in bpm) and 17% (when expressed in %MPHR). The CHB-group, compared to the CG, included higher percentages of participants with chronotropic insufficiency and abnormal 6MWD (23.08% vs. 3.57%, and 34.61% vs. 3.57%, respectively). The CHB-group was 8.1 and 14.3 times more likely to have chronotropic insufficiency and abnormal 6MWD than the CG, respectively. CHB accelerated the aging of the cardiorespiratory and muscular chain by 11 years.</p><p><strong>Conclusion: </strong>Non-cirrhotic CHB may contribute to reduced submaximal aerobic capacity and acceleration of cardiorespiratory and muscular chain aging.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"98"},"PeriodicalIF":0.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First Report of <i>Ganoderma ryvardenii</i> causing Basal Stem Rot (BSR) disease on oil palm ( <i>Elaeis guineensis</i> Jacq.) in Ghana.","authors":"Emmanuellah Lekete-Lawson, Grace C van der Puije, Enoch A Osekre, Frank K Ackah","doi":"10.12688/f1000research.161972.1","DOIUrl":"10.12688/f1000research.161972.1","url":null,"abstract":"<p><strong>Backgrounds: </strong>Oil palm ( <i>Elaeis guineensis</i> Jacq.), is the most significant and highest-yielding crop among oil-producing crops worldwide. In 2020/2022, Basal stem rot (BSR) disease was observed in six oil palm growing Districts in Ghana.</p><p><strong>Methods: </strong>Field study and laboratory analysis were conducted. A random sampling technique was used to select five plantation blocks from each District. Single-point disease assessments were done using Standard Operating Procedure (SOP) with a severity scale of 0-4. Molecular assays were performed on each sample using nucleic acid as a template. ITS and GanET sequence analysis were performed along with the formation of a phylogenetic tree using the FASTA algorithm with the Fungus database from EBI and NCBI GenBank. Koch's postulate was followed to confirm the disease.</p><p><strong>Results: </strong>The disease incidence was 11.3 % with the highest severity score of 4. BSR is characterised by stem decay large-perennial, woody brackets basidiocarps of average measurement of 2-65 cm in diameter on infected palms. Culture colonies were white, striated, undulating, woolly-cottony, and creamish pigment on the reverse depicting attributes of <i>Ganoderma</i> fungus. Molecular confirmation was done by combining ITS sequence of top matches of >97% to members of the genus <i>Ganoderma</i>, >98% and 99.3% identity to three sequences of <i>Ganoderma</i> sp. (HM138671; HM138670 and HM138672) generated from strains assigned to <i>Ganoderma ryvardenii</i> and compared with 132 published sequences of <i>Ganoderma</i> isolates.</p><p><strong>Conclusion: </strong>This is the first report of <i>Ganoderma ryvardenii</i> causing BSR disease on oil palm in Ghana and possibly the second report in Africa. However, the pathogen was first reported to cause similar diseases in oil palm in Cameroon.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"413"},"PeriodicalIF":0.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diversity, Distribution, and Phenotypic Characterization of Cultivable Wild Yeasts Isolated from Natural Forest.","authors":"Teshome Tadesse, Degife Dese, Anbessa Dabassa, Ketema Bacha","doi":"10.12688/f1000research.160250.3","DOIUrl":"https://doi.org/10.12688/f1000research.160250.3","url":null,"abstract":"<p><strong>Background: </strong>Yeasts are unicellular fungi that inhabit a variety of environments including plant surfaces, water, soil, and animal hosts. However, limited research has been conducted on soil and plant associated yeasts in Africa, with most studies originating from developed regions.</p><p><strong>Methods: </strong>This study explored the diversity, distribution, and phenotypic characterization of cultivable wild yeast in samples from rhizosphere soil, leaves, litter, and tree bark collected from South West Ethiopia. Yeast isolates were characterized using morphological, physiological and biochemical methods, Stress-tolerant yeast species were identified using Matrix-Assisted Laser Desorption Ionization-Time of Flight (MALDI-TOF).</p><p><strong>Results: </strong>Based on morphological, physiological, and biochemical analyses, a total of 15 yeast genera were identified from 23 plant species. Predominant yeast species included <i>Candida</i> spp., <i>Saccharomyces</i> spp., <i>Meyerozyma</i> spp., <i>Pichia</i> spp., <i>Geotrichum</i> spp., and <i>Hanseniaspora</i> spp. Plant species with the highest yeast diversity were <i>Ficus vasta</i>, <i>Ficus exasperata</i>, <i>Ficus sycomorus</i>, <i>Cordia africana</i>, and <i>Ritchiea albersii.</i> Bark samples yielded more yeast isolates than rhizosphere soil, litter, and leaves. Stress-tolerant species such as <i>Saccharomyces cerevisiae</i>, <i>Candida pelliculosa</i>, <i>Meyerozyma guilliermondii</i>, <i>Pichia kluyveri</i>, and <i>Trichosporon asahii</i> were identified using MALDI-TOF. Correlation analysis revealed no significant relationship between yeast populations in bark and leaf samples or between rhizosphere soil and leaves, though a weak positive correlation was found between rhizosphere soil and bark or litter. Seasonal analysis showed a strong positive correlation between yeast abundance in spring and summer, but no association between autumn and spring.</p><p><strong>Conclusion: </strong>Ethiopian forests are home for various yeast species including the stress-tolerant wild yeasts. This study highlights the significant yeast diversity in Ethiopian forests, with potential applications in improving industrial fermentation processes that operate under stressful conditions.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"105"},"PeriodicalIF":0.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the relationship between macroeconomic indicators and sectoral indices of Indian stock market.","authors":"Sanjay Singh Chauhan, Pradeep Suri, Bhekisipho Twala, Neeraj Priyadarshi, Farman Ali","doi":"10.12688/f1000research.160668.2","DOIUrl":"https://doi.org/10.12688/f1000research.160668.2","url":null,"abstract":"<p><strong>Background of the study: </strong>The influence of macroeconomic indicators makes it important to study the relationship between macroeconomic indicators and stock market return. On further analysis it can be observed that different sectors respond differently to change in the macroeconomic indicator that is important for investors, researchers and policy makers.</p><p><strong>Methods: </strong>The autoregressive distributed lag (ARDL) model is applied to study influence of macroeconomic indicators on sectoral return of NSE from April 2012 to August 2024.</p><p><strong>Results: </strong>Findings of the study show that macroeconomic indicators influence sectoral return in the short run as well as long run and the influence is differential. The analysis of long run relationship shows that Foreign Institutional Investment (FII) significantly affects all the sectoral indices except IT. Index of industrial production (IIP) have significant relationship with Auto, IT, Media, Metal and Pharma. Money supply (MS) significantly affects Bank, FMCG and IT in the long run. Wholesale Price Index (WPI) has significant relationship with Auto, FMCG and Media in the long run. Economic Policy Uncertainty Index (EPU) affects Auto, FMCG and Pharma in the long run. Crude oil price (COP) has significant effect only on Media in the long run. Exchange rate (ER) does not have significant effect on any of the sectoral index.</p><p><strong>Conclusion: </strong>In the long run FII, IIP, EPU, MS and WIP are major determinants of stock market return. In the short run FII, ER and COP are major determinants of stock market return.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"180"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lived experiences of women who survived from pre-eclampsia and eclampsia in public hospitals of Shashemene Town, Oromia Region, Ethiopia: a qualitative study.","authors":"Negeso Gebeyehu, Aman Urgessa, Daniel Yohannes, Aster Yalew, Muluneh Ahmed, Meron Admasu","doi":"10.12688/f1000research.129648.3","DOIUrl":"https://doi.org/10.12688/f1000research.129648.3","url":null,"abstract":"<p><strong>Objective: </strong>The main purpose of this study was to explore experiences of women who survived pre-eclampsia and eclampsia in Shashemene referral hospital and Melka Oda general hospital, 2021.</p><p><strong>Design: </strong>An institution-based exploratory qualitative study with a descriptive phenomenological study design.</p><p><strong>Setting: </strong>The present study was conducted in Shashemene referral hospital and Melka Oda general hospital from March 03 to May 18, 2021.</p><p><strong>Participants: </strong>A total of 17 individual in-depth interviews (IDIs) were conducted with women who experienced and survived pre-eclampsia and eclampsia. Data were analyzed through thematic analysis using Atlas-ti software.</p><p><strong>Result: </strong>The present study revealed that women's level of awareness on raised blood pressure and or convulsion occurring during pregnancy was poor. Barriers that limit pregnant women from getting treatment at the earliest point included misconception, lack of insight, failure to accept counseling from health care providers, low income, and influence from husbands. Discussions with the women in this study showed that these mothers were not counseled on danger signs during antenatal care check-ups. Almost all of the women were very concerned and frustrated due to their diagnosis.</p><p><strong>Conclusions: </strong>Women's awareness of pre-eclampsia and eclampsia was poor. Improving awareness of hypertensive disorders in pregnancy and enhancing the quality of antenatal care is essential.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"12 ","pages":"1464"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The quantified method for blood clot detection in the extraction socket.","authors":"Suwat Tanya, Piyachat Patcharanuchat, Sajee Sattayut","doi":"10.12688/f1000research.155330.1","DOIUrl":"10.12688/f1000research.155330.1","url":null,"abstract":"<p><strong>Background: </strong>Currently, there is no objective and quantified measurement for detecting blood clots during extraction socket hemostasis. It has relied solely on clinical observation, even when conducting clinical research by using extraction sockets as samples. This study aimed to assess the in vitro reliability and clinical-relevant validity of a new objective measurement providing quantified data called blood clot detection (BCD) using a standard capillary tube.</p><p><strong>Methods: </strong>The in vitro part of the study was conducted using surplus blood samples from ten healthy participants. Two identical sets of blood samples in simulation reservoirs mimicking bleeding sockets were prepared for reliability tests. Then, the capillary tubes were concurrently placed in the reservoirs. The blood-filled distances were measured. The part of clinical-relevant validity study was conducted in sixteen extraction sockets from each healthy participant. Clinical observation and BCD measurement were evaluated by two calibrated assessors. The total duration of the assessment was a 30-minute.</p><p><strong>Results: </strong>The distances of the blood-filled capillary tube were decreased by time. Test and retest reliability analysis of the BCD measurement showed an excellent intraclass correlation coefficient of 0.980 (0.968 to 0.988). The medians of blood-filled distance categorized by clinical observation into active bleeding, sluggish oozing, and clot formation were 13.0 mm (Q1 = 11.7, Q3 = 13.8), 5.6 mm (Q1 = 4.3, Q3 = 7.0), and 0.9 mm (Q1 = 0.5, Q3 = 1.3), respectively. The blood-filled distance of the clot formation group was significantly less than the active bleeding and sluggish oozing (p<0.001). Therefore, the BCD measurement also significantly indicated the completion of extraction socket hemostasis.</p><p><strong>Conclusions: </strong>A distance of blood-filled in capillary tube of 0.9 mm from the BCD measurement significantly ensured complete clot formation. The BCD measurement proved to be a quantified tool for objectively measuring hemostasis of bleeding socket.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1043"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11914871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Methimazole-Induced Parotitis - An Unusual Presentation.","authors":"Ricky Rana, Emily Krier, Abubakar Tauseef, Jalal Dufani","doi":"10.12688/f1000research.149569.3","DOIUrl":"https://doi.org/10.12688/f1000research.149569.3","url":null,"abstract":"<p><p>A 56-year-old female with a medical history of unspecified hyperthyroidism and a recent thyroid storm presented to the ED with tachycardia, hypertension, and bilateral enlarged parotid glands. During a previous hospitalization, she was diagnosed with unspecified hyperthyroidism and started on methimazole. During hospitalization, laboratory findings suggested Graves' disease with an acute thyroid storm. The patient also complained of enlarged parotid glands bilaterally. CT tomography of the neck revealed no calculi of the parotid glands but showed extensive fatty replacement, possibly related to methimazole use. Treatment with propranolol and IV hydrocortisone improved thyroid function. Due to the suspicion of methimazole-induced parotitis, she was transitioned to a reduced methimazole dosage for treatment of Graves' disease, which subsequently improved her parotitis. Methimazole, the standard initial treatment for Graves' disease, is generally well-tolerated. It can cause adverse reactions; however, parotitis is very rare and has been documented in only a few case reports. Owing to the limited number of reports, its incidence is currently unknown. Here, we present a case of methimazole-induced parotitis as an unusual presentation of thyroid storm. Drug-induced reactions can only be considered once common causes of parotitis such as viral infection, obstruction, and autoimmune diseases are ruled out. Treatment involves dosage adjustments and supportive care. Methimazole-induced parotitis is often misdiagnosed and overlooked because of the lack of reported cases. This necessitates future research into the reaction mechanisms and optimal treatment.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"447"},"PeriodicalIF":0.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12032518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fostering healthcare system sustainability through efficient practices: Can adopting biosimilars ease the financial burden of rheumatoid arthritis?","authors":"Christos Ntais, Nikolaos Kontodimopoulos, John Fanourgiakis, Michael A Talias","doi":"10.12688/f1000research.156983.2","DOIUrl":"https://doi.org/10.12688/f1000research.156983.2","url":null,"abstract":"<p><p>Immune-mediated inflammatory diseases like rheumatoid arthritis (RA) have been successfully treated using biologic disease-modifying antirheumatic drugs. These medications are not utilized as first-line treatment, in part because of their high cost, but they are frequently seen to be cost-effective for RA patient populations that do not respond adequately to conventional disease-modifying antirheumatic drugs. Moreover, not all RA patients who meet clinical eligibility criteria can access biologics, not even as second-line therapy. Recently, there has been an increasing interest in biosimilars that are highly comparable to their originator biologics in terms of efficacy and safety but generally come at a lower price. This review summarizes the potential role of biosimilars in reducing RA expenditure and increasing RA patient access to biologic therapies. As the global landscape for biosimilars continues to evolve, it is essential to consider the unique challenges and opportunities in different healthcare systems. By leveraging the potential of biosimilars, healthcare systems can improve RA management, ease its economic burden and ensure that patients have access to effective and affordable treatments. The future of RA treatment lies in the integration of biosimilars into clinical practice, offering hope for more sustainable and equitable healthcare systems.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1128"},"PeriodicalIF":0.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11983381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}