F1000Research最新文献

{"title":"Structuring data analysis projects in the Open Science era with Kerblam!","authors":"Luca Visentin, Luca Munaron, Federico Alessandro Ruffinatti","doi":"10.12688/f1000research.157325.1","DOIUrl":"10.12688/f1000research.157325.1","url":null,"abstract":"<p><strong>Background: </strong>Structuring data analysis projects, that is, defining the layout of files and folders needed to analyze data using existing tools and novel code, largely follows personal preferences. Open Science calls for more accessible, transparent and understandable research. We believe that Open Science principles can be applied to the way data analysis projects are structured.</p><p><strong>Methods: </strong>We examine the structure of several data analysis project templates by analyzing project template repositories present in GitHub. Through visualization of the resulting consensus structure, we draw observations regarding how the ecosystem of project structures is shaped, and what salient characteristics it has.</p><p><strong>Results: </strong>Project templates show little overlap, but many distinct practices can be highlighted. We take them into account with the wider Open Science philosophy to draw a few fundamental Design Principles to guide researchers when designing a project space. We present Kerblam!, a project management tool that can work with such a project structure to expedite data handling, execute workflow managers, and share the resulting workflow and analysis outputs with others.</p><p><strong>Conclusions: </strong>We hope that, by following these principles and using Kerblam!, the landscape of data analysis projects can become more transparent, understandable, and ultimately useful to the wider community.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"88"},"PeriodicalIF":0.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143565976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is relief the most common reaction to abortion? Self-assessed intensity of emotions attributed to abortion in a national sample of women aged 41 to 45.","authors":"David Reardon","doi":"10.12688/f1000research.162063.1","DOIUrl":"10.12688/f1000research.162063.1","url":null,"abstract":"<p><strong>Background: </strong>It is widely reported that the most prominent emotion following abortions is relief. This claim primarily rests on two studies of abortion clinic patients which had methodological and self-censure bias. Other studies have indicated that negative emotions are more common than positive emotions. The objective of this study is to obtain self-assessed data on the intensity of emotional responses to abortion and pregnancy loss in a random national sample.</p><p><strong>Methods: </strong>Using visual analog scales, a random sample of 1,925 women aged 41 to 45 completed a survey in which respondents rated the degree to which they experienced emotional responses to their first abortion or natural pregnancy loss. The emotions assessed included relief, grief, depression, anxiety, guilt, emptiness, anger, regret, shame, unforgiveness of self, uncontrollable weeping, frequent thoughts of the child they could have had, and difficulty completing the grief process. Women were categorized into five groups based on pregnancy outcomes, and four abortion decision types: Wanted, Inconsistent, Unwanted, or Coerced.</p><p><strong>Results: </strong>Among women with a history of abortion (n=409), negative emotions were reported more intensely than relief. Relief was the predominant emotion only among the 29.8% of women whose abortions were freely wanted and consistent with their own values and preferences. For all other groups, relief was low and negative emotions were more prominent. Emotions following natural pregnancy losses were similar to those following abortion, but less severe following wanted abortions and more severe following coerced abortions.</p><p><strong>Conclusions: </strong>Relief is only common after freely wanted abortions. Most abortions are inconsistent or contrary to women's own values. In these cases, strong negative emotions are far more dominant than relief. These results should inform pre-abortion screening, counseling supportive of women's own values and preferences, and mental health support post-abortion.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"240"},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11933783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodology used to develop the minimum common data elements for surveillance and Reporting of Musculoskeletal Injuries in the MILitary (ROMMIL) statement.","authors":"Garrett S Bullock, Joanne L Fallowfield, Sarah J de la Motte, Nigel Arden, Ben Fisher, Adam Dooley, Neil Forrest, John J Fraser, Alysia Gourlay, Ben R Hando, Katherine Harrison, Debra Hayhurst, Joseph M Molloy, Phillip M Newman, Eric Robitaille, Deydre S Teyhen, Jeffrey M Tiede, Emma Williams, Sandra Williams, Damien Van Tiggelen, Joshua J Van Wyngaarden, Richard B Westrick, Carolyn A Emery, Gary S Collins, Daniel I Rhon","doi":"10.12688/f1000research.152514.1","DOIUrl":"10.12688/f1000research.152514.1","url":null,"abstract":"<p><strong>Background: </strong>The objective was to summarize the methodology used to develop the international minimum data elements for surveillance and Reporting of Musculoskeletal Injuries in the MILitary (ROMMIL) statement. This is a recommended list of elements to be collected and reported when conducting injury surveillance research in military settings.</p><p><strong>Methods: </strong>A Delphi methodology was employed to reach consensus. Preliminary steps included conducting a literature review and surveying a convenience sample of military stakeholders to 1) identify barriers and facilitators of military musculoskeletal injury (MSKI) prevention programs, 2) identify relevant knowledge gaps, and 3) establish future research priorities. A sequential three-round Delphi consensus survey followed, including relevant stakeholders from militaries around the world, using results to conduct an asynchronous knowledge user meeting (mixture of in-person and live video conference and recording) to explore the level of agreement among subject matter experts. Knowledge users, including former and current military service members, civilian practitioners working in military health networks, and international subject matter experts having experience with policy, execution, or clinical investigation of MSKI mitigation programs, MSKI diagnoses, and MSKI risk factors in military settings. For each round, participants scored questions on a Likert scale of 1-5. Scores ranged from No Importance (1) to Strong Importance (5).</p><p><strong>Results: </strong>Literature review and surveys helped inform the scope of potential variables. Three rounds were necessary to reach minimum consensus. Ninety-five, 65, and 42 respondents participated in the first, second and third rounds, respectively.</p><p><strong>Conclusions: </strong>Achieving consensus across relevant knowledge users representing military organizations globally can be challenging. This paper details the methodology employed to reach consensus for a core minimum data elements checklist for conducting MSKI research in military settings and improve data harmonization and scalability efforts. These methods can be used as a resource to assist in future consensus endeavors of similar nature.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1044"},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11621606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Searching for non-English literature may be unnecessary for German HTA Reports.","authors":"Elke Hausner, Sibylle Sturtz, Sandra Molnar, Lisa Schell, Wiebke Sieben, Stefan Sauerland","doi":"10.12688/f1000research.151365.2","DOIUrl":"https://doi.org/10.12688/f1000research.151365.2","url":null,"abstract":"<p><strong>Background: </strong>Health technology assessment (HTA) reports are based on comprehensive information retrieval. Current standards discourage the use of search restrictions, such as publication date and language. Given limited resources, it was unclear whether the effort invested in screening and translating studies published in languages other than English provided relevant additional information compared with the inclusion of English-language publications alone. We therefore analysed the impact of non-English publications on the conclusions of HTA reports produced by the German HTA agency, the Institute for Quality and Efficiency in Health Care (IQWiG).</p><p><strong>Methods: </strong>We determined whether non-English publications were included in all German HTA reports on non-drug interventions (published by IQWiG between 06/2007 to 08/2018) and on selected drug interventions. If at least one non-English publication was included, we assessed for each endpoint whether or not the exclusion of non-English publications changed the conclusion. If a non-English publication did not contain information relevant to the HTA report, we classified the publication as \"not relevant\".</p><p><strong>Results: </strong>Of 70 HTA reports, 38 (54%) included 126 non-English publications. In 4 reports (6%) with 50 endpoints investigated in 39 PICO questions, the exclusion of a total of 10 non-English publications led to a change in the conclusions for 13 endpoints (8 PICO questions). This was largely due to the fact that in many cases, non-English publications were the predominant or only literature available, resulting in a lack of analysable data after their exclusion.</p><p><strong>Conclusions: </strong>In general, studies only published in non-English languages have little influence on the conclusions of German HTA reports. For the vast majority of topics, a language restriction to English seems justified. Studies published in non-English languages may be useful in exceptional cases, for example when an intervention is only available in certain countries.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1134"},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12012429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of surface treatments on the bond strength of polyetheretherketone posts: a systematic review protocol.","authors":"Hanen Boukhris, Aymen Ben Hadj Khalifa, Hayet Hajjami, Souha Boudegga Ben Youssef","doi":"10.12688/f1000research.154750.3","DOIUrl":"https://doi.org/10.12688/f1000research.154750.3","url":null,"abstract":"<p><strong>Background: </strong>Polyetheretherketone (PEEK) is widely used in the biomedical field due to its outstanding biological and mechanical properties. Originally employed as a temporary abutment in implantology, recent research has expanded its indications for more definitive applications, such as frameworks and dental post and core. However, PEEK's inert nature and low surface energy pose challenges for adhesion, necessitating surface modifications. Various physical and chemical modification techniques, including acid etching (e.g., 98% sulfuric acid), sandblasting with alumina oxide (Al₂O₃), plasma treatment, laser irradiation, silanization, and air abrasion with silica-coated particles, have been proposed to enhance PEEK's bonding performance. Despite numerous clinical investigations, standardized protocols for surface treatment remain lacking. This systematic review aims to assess the impact of surface treatments on the bonding performance of PEEK posts.</p><p><strong>Methods: </strong>A detailed search of the literature will be conducted across several databases including PubMed, Scopus and clinical trial registries. Additional databases such as Cochrane Central, EMBASE, Web of Science and EBSCO will also be included. The search strategy will target controlled randomized studies and non-randomized clinical trials evaluating the impact of surface treatments on PEEK post adhesion strength. The Newcastle-Ottawa Scale (NOS) will be used to assess bias in non-randomized studies, while the Cochrane Risk of Bias (ROB II) tool will be employed for evaluating randomized controlled trials. Data extraction will focus on study design, treatment methods, outcomes and results.This systematic review protocol will adhere to the guidelines for systematic reviews outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).</p><p><strong>Discussion: </strong>The discussion will explore the implications of findings on clinical practice, highlighting the importance of enhancing PEEK's bioactivity and surface energy to improve bonding efficacy in dental procedures. Moreover, it will suggest areas for future research to advance dental materials science, aiming to optimize the utilization of PEEK in dental applications.</p><p><strong>Systematic review registration: </strong>PROSPERO: CRD42024529783 (Registered on 08/04/2024).</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"951"},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12008716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report- Prevention strategies for permanent tracheostomy tube migration into the left main bronchus in tracheostomized patients.","authors":"Said Khallikane, Amine Bentahar, Monsif Salek, Ayoub Belhadj, Younès Aissaoui","doi":"10.12688/f1000research.163217.1","DOIUrl":"https://doi.org/10.12688/f1000research.163217.1","url":null,"abstract":"<p><p>Tracheostomy tube migration is a rare but potentially life-threatening complication. We present the case of a 66-year-old male with chronic obstructive pulmonary disease, dual-chamber pacemaker implantation for chronic ischemic cardiomyopathy, and supraglottic squamous cell carcinoma. The patient developed respiratory distress due to intrabronchial migration of the tracheostomy tube. Initial evaluation revealed significant respiratory effort, inspiratory stridor, and an absent tube at the stoma site. Imaging and bronchoscopy confirmed the tube's presence in the left main bronchus with associated mucosal inflammation. The patient underwent bronchoscopic-guided tube removal and successful repositioning of a cuffed tracheostomy tube under spontaneous ventilation anaesthesia. Following stabilization, he was discharged with plans for a permanent tracheostomy. Tracheostomy tube migration presents a significant diagnostic and therapeutic challenge, particularly given the scarcity of studies involving adults with this complication. This case highlights the importance of early recognition, prompt imaging-especially bronchoscopy-and tailored management strategies, while emphasizing the active involvement of the patient and family in the care pathway. It also underscores the necessity for vigilant monitoring to prevent severe, potentially fatal, complications.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"372"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing common inferential mistakes when failing to reject the null-hypothesis.","authors":"Amand Schmidt","doi":"10.12688/f1000research.158434.2","DOIUrl":"10.12688/f1000research.158434.2","url":null,"abstract":"<p><p>Failure to reject a null-hypothesis may lead to erroneous conclusions regarding the absence of an association or inadequate statistical power. Because an estimate (and its variance) can never be exactly zero, traditional statistical tests cannot conclusively demonstrate the absence of an association. Instead, estimates of accuracy should be used to identify settings in which an association and its variability are sufficiently small to be clinically acceptable, directly providing information on safety and efficacy. Post-hoc power calculations should be avoided, as they offer no additional information beyond statistical tests and p-values. Furthermore, post-hoc power calculations can be misleading because of an inability to distinguish between results based on insufficient sample size and results that reflect clinically irrelevant differences. Most multiple testing procedures unrealistically assume that all positive results are false positives. However, in applied settings, results typically represent a mix of true and false positives. This implies that multiplicity corrections do not effectively differentiate between true and false positives. Instead, considering the distributions of p-values and the proportion of significant results can help to identify bodies of evidence unlikely to be driven by false-positive results. In conclusion, rather than attempting to categorize results as true or false, medical research should embrace established statistical methods that focus on estimation accuracy, replication, and consistency.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1488"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of non-linear thermal radiation and Cattaneo-Christov heat and mass fluxes on the flow of Williamson hybrid nanofluid over a stretching porous sheet.","authors":"Asfaw Tsegaye, Eshetu Haile, Gurju Awgichew, Hunegnaw Dessie","doi":"10.12688/f1000research.160734.2","DOIUrl":"10.12688/f1000research.160734.2","url":null,"abstract":"<p><strong>Background: </strong>Hybrid nanofluids, consisting of two distinct nanoparticles dispersed in a base fluid, are widely used in industries requiring enhanced heat and mass transfer, such as cooling systems and heat exchangers. These fluids improve thermal conductivity and fluid dynamics, leading to better heat management and energy efficiency. This study investigates the combined effects of non-linear thermal radiation, Cattaneo-Christov heat and mass fluxes, and other factors on the three-dimensional flow, heat, and mass transfer of a Williamson hybrid nanofluid. The flow occurs over a stretching porous sheet subjected to an external magnetic field, Joule heating, chemical reactions, and heat generation.</p><p><strong>Methods: </strong>Copper (Cu) and aluminum oxide (Al₂O₃) nanoparticles are suspended in ethylene glycol (C₂C₆O₂) to form the hybrid nanofluid. The governing partial differential equations are transformed into ordinary differential equations using similarity transformations and solved numerically with MATLAB's bvp4c solver. The study examines various parameters, including stretching ratio, nanoparticle volume fraction, and relaxation times for concentration and thermal effects. Results are validated against existing literature.</p><p><strong>Results: </strong>The findings reveal that a higher stretching ratio reduces velocity, temperature, concentration profiles, and local Nusselt and Sherwood numbers, while also lowering skin friction and secondary velocity. Increasing nanoparticle volume fraction decreases velocity and temperature profiles but enhances skin friction, local Nusselt, and Sherwood numbers. Concentration profiles decline with higher concentration relaxation time, while temperature increases with longer thermal relaxation time.</p><p><strong>Conclusions: </strong>In conclusion, Cu-Al₂O₃/C₂C₆O₂ hybrid nanofluids demonstrate superior heat and mass transfer capabilities compared to mono-nanofluids. The performance is significantly influenced by parameters such as nanoparticle volume fraction, relaxation times, and the stretching ratio, providing valuable insights for heat and mass transfer applications.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"210"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coexisting nephrotic syndromes influences in st elevation myocardial infarction patient and chronic limb-threatening ischemia patient: is there any correlation?","authors":"Iwan Dakota, Taofan Taofan, Suci Indriani, Jonathan Edbert Afandy, Mikhael Asaf, Swastya Dwi Putra, Suko Adiarto, Renan Sukmawan","doi":"10.12688/f1000research.134021.2","DOIUrl":"10.12688/f1000research.134021.2","url":null,"abstract":"<p><strong>Background: </strong>ST-elevation myocardial infarction (STEMI) and chronic limb-threatening ischemia (CLTI) are severe cardiovascular emergencies requiring urgent intervention. Nephrotic syndrome (NS) increases the risk of arterial thromboembolism (ATE), but its exact contribution remains underrecognized.</p><p><strong>Case illustration: </strong>We present three cases of young adults with NS who developed ATE. The first patient had anterior STEMI with high thrombus burden but no significant atherosclerosis, suggesting a thromboembolic event. The second patient, diagnosed with CLTI, had extensive thrombotic occlusions from the infrarenal aorta to the bilateral superficial femoral arteries without atherosclerotic plaques, reinforcing a thromboembolic mechanism. He declined revascularization and was treated with medical therapy, achieving symptom relief. The third patient had CLTI with occlusions in the external iliac and superficial femoral arteries, accompanied by prominent plaque calcification, suggesting an atherosclerotic contribution. He underwent percutaneous transluminal angioplasty with favorable outcomes.</p><p><strong>Conclusion: </strong>NS predisposes patients to ATE via hypercoagulability and, in some cases, atherosclerosis. Cardiovascular screening should be prioritized in high-risk patients, and preventive measures, including thromboprophylaxis and lipid management, should be considered. Treatment should be individualized based on the predominant mechanism, with deferred stenting in high thrombus burden STEMI and a multidisciplinary approach for CLTI. Long-term follow-up is essential to prevent recurrence.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"12 ","pages":"538"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphology of the obturator nerve, an anatomical study with emphasis on its clinical implications.","authors":"Latha V Prabhu, Rajanigandha Vadgaonkar, Ashwin R Rai, Vandana Blossom, Mangala M Pai, B V Murlimanju","doi":"10.12688/f1000research.147000.2","DOIUrl":"https://doi.org/10.12688/f1000research.147000.2","url":null,"abstract":"<p><strong>Background: </strong>The goal of this cadaveric cross-sectional study was to analyse the branching pattern of the obturator nerve morphologically and to determine its dimensions in embalmed cadavers.</p><p><strong>Methods: </strong>In this cross-sectional study, we examined 50 embalmed adult cadaveric lower limbs. Gender was not taken into consideration in the analysis; however, a side-based comparison was performed. The measurements were performed using a digital Vernier caliper.</p><p><strong>Results: </strong>The branching of obturator nerve was observed at the pelvic cavity in 28 specimens (56%) and inside the obturator canal in 12 specimens (24%). The division of obturator nerve wasn't observed in 10 specimens (20%). The length, width and thickness of the trunk of obturator nerve was 108.26 ± 9.53 mm, 2.84 ± 0.88 mm and 1.11 ± 0.35 mm. The width and thickness of the anterior and posterior divisions of obturator nerve measured 2.19 ± 0.82 mm, 0.9 ± 0.1 mm, 0.99 ± 0.6 mm and 0.71 ± 0.26 mm. The topography of branching of obturator nerve from the superior and inferior border of the obturator foramen was located at 1.48 ± 0.58 mm and 3.07 ± 1.1 mm away. The length of anterior division of the obturator nerve measured 110.88 ± 12.02 mm over the right side and 107.13 ± 7.81 mm over the left side. The width of the main trunk of obturator nerve was 2.87 ± 0.64 mm over the right side and 2.82 ± 0.64 mm over the left side.</p><p><strong>Conclusions: </strong>We believe that morphometric data of the obturator nerve will be enlightening to the operating surgeon during its procedures like nerve block, transplantation, and repairs as few of them are conducted laparoscopically, the prior knowledge of morphological dimensions and branching pattern will assist the surgeons in easy access of the obturator nerve. In this context, the dimensions of the obturator nerve observed in the present study can be utilized as a morphological database for our sample population.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"329"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}