Hamzah Hamzah, Suryanti Suryanti, Idris Adewale Ahmed, Bambang Pujo Semedi, Abdullah Machin, Aditya Tri Hernowo
{"title":"氧传递纳米泡在脑卒中治疗中的作用：一种新方法。","authors":"Hamzah Hamzah, Suryanti Suryanti, Idris Adewale Ahmed, Bambang Pujo Semedi, Abdullah Machin, Aditya Tri Hernowo","doi":"10.12688/f1000research.162742.3","DOIUrl":null,"url":null,"abstract":"<p><p>Stroke remains a leading cause of mortality and long-term disability worldwide, necessitating innovative therapeutic strategies. The advent of nanotechnology, particularly oxygen-delivering nanobubbles (ODNBs), has introduced a promising avenue for enhancing stroke therapy. ODNBs have demonstrated the ability to improve oxygen delivery, enhance therapeutic efficacy, and provide diagnostic advantages through imaging contrast enhancement. However, challenges such as toxicity, off-target effects, and regulatory hurdles must be addressed before clinical translation. This review synthesizes the latest findings on ODNBs in stroke therapy, highlights their key benefits and challenges, and explores future applications, including gene therapy and brain tissue regeneration. By addressing these aspects, this review aims to provide a comprehensive understanding of the potential of ODNBs in revolutionizing stroke treatment.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"406"},"PeriodicalIF":0.0000,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12405841/pdf/","citationCount":"0","resultStr":"{\"title\":\"Review the role of oxygen-delivering nanobubbles in stroke therapy: A novel approach.\",\"authors\":\"Hamzah Hamzah, Suryanti Suryanti, Idris Adewale Ahmed, Bambang Pujo Semedi, Abdullah Machin, Aditya Tri Hernowo\",\"doi\":\"10.12688/f1000research.162742.3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Stroke remains a leading cause of mortality and long-term disability worldwide, necessitating innovative therapeutic strategies. The advent of nanotechnology, particularly oxygen-delivering nanobubbles (ODNBs), has introduced a promising avenue for enhancing stroke therapy. ODNBs have demonstrated the ability to improve oxygen delivery, enhance therapeutic efficacy, and provide diagnostic advantages through imaging contrast enhancement. However, challenges such as toxicity, off-target effects, and regulatory hurdles must be addressed before clinical translation. This review synthesizes the latest findings on ODNBs in stroke therapy, highlights their key benefits and challenges, and explores future applications, including gene therapy and brain tissue regeneration. By addressing these aspects, this review aims to provide a comprehensive understanding of the potential of ODNBs in revolutionizing stroke treatment.</p>\",\"PeriodicalId\":12260,\"journal\":{\"name\":\"F1000Research\",\"volume\":\"14 \",\"pages\":\"406\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-08-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12405841/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"F1000Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.12688/f1000research.162742.3\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"Pharmacology, Toxicology and Pharmaceutics\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"F1000Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.12688/f1000research.162742.3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
Review the role of oxygen-delivering nanobubbles in stroke therapy: A novel approach.
Stroke remains a leading cause of mortality and long-term disability worldwide, necessitating innovative therapeutic strategies. The advent of nanotechnology, particularly oxygen-delivering nanobubbles (ODNBs), has introduced a promising avenue for enhancing stroke therapy. ODNBs have demonstrated the ability to improve oxygen delivery, enhance therapeutic efficacy, and provide diagnostic advantages through imaging contrast enhancement. However, challenges such as toxicity, off-target effects, and regulatory hurdles must be addressed before clinical translation. This review synthesizes the latest findings on ODNBs in stroke therapy, highlights their key benefits and challenges, and explores future applications, including gene therapy and brain tissue regeneration. By addressing these aspects, this review aims to provide a comprehensive understanding of the potential of ODNBs in revolutionizing stroke treatment.
F1000ResearchPharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
5.00
自引率
0.00%
发文量
1646
审稿时长
1 weeks
期刊介绍：
F1000Research publishes articles and other research outputs reporting basic scientific, scholarly, translational and clinical research across the physical and life sciences, engineering, medicine, social sciences and humanities. F1000Research is a scholarly publication platform set up for the scientific, scholarly and medical research community; each article has at least one author who is a qualified researcher, scholar or clinician actively working in their speciality and who has made a key contribution to the article. Articles must be original (not duplications). All research is suitable irrespective of the perceived level of interest or novelty; we welcome confirmatory and negative results, as well as null studies. F1000Research publishes different type of research, including clinical trials, systematic reviews, software tools, method articles, and many others. Reviews and Opinion articles providing a balanced and comprehensive overview of the latest discoveries in a particular field, or presenting a personal perspective on recent developments, are also welcome. See the full list of article types we accept for more information.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
