F1000Research最新文献

{"title":"In silico molecular docking and molecular dynamic simulation of agarwood compounds with molecular targets of Alzheimer's disease .","authors":"Phaniendra Alugoju, Vishwambar Vishnu Bhandare, Vishal S Patil, Krishna Swamy V K D, Prem Kumar Borugadda, Tewin Tencomnao","doi":"10.12688/f1000research.130618.2","DOIUrl":"10.12688/f1000research.130618.2","url":null,"abstract":"<p><strong>Background: </strong>Alzheimer's disease (AD) is a neurological condition that primarily affects older people. Currently available AD drugs are associated with side effects and there is a need to develop natural drugs from plants. Aquilaria is as an endangered medicinal plant genus (commonly called agarwood plants) and various products of Aquilaria plant spp. including resinous heartwood, leaves, bark, and stem have been widely used in various traditional medicine systems. Research on agarwood plants is sparse and only a few previous studies demonstrated their neuroprotective properties <i>in vitro.</i> Owing to the presence of a plethora of secondary metabolites in agarwood plants, it is imperative not only to protect these plants but also evaluate the bioactivity of agarwood phytochemicals.</p><p><strong>Methods: </strong>This study used Molsoft tools to predict the physicochemical properties of agarwood ligands, including the number of H-bond donors and acceptors, polar surface area, lipophilicity, solubility, and the molecular polar surface area and volume of agarwood ligands. Additionally, ADMET (absorption, digestion, metabolism, excretion, and toxicity) properties were predicted using ADMETlab 2.0. Computational methods such as AutoDock Vina and molecular dynamic (MD) simulations were employed for the docking of 41 selected agarwood compounds with AD-related molecular targets.</p><p><strong>Results and conclusion: </strong>According to docking data, three compounds aquilarisin (ASN), aquilarisinin (ANN), aquilarixanthone (AXN) showed highest binding affinity to selected AD targets compared to their known inhibitors. MD simulation studies revealed that, selected agarwood compounds' protein-ligand complexes showed remarkable structural stability throughout 100ns simulation. The agarwood chemicals aquilarisin, aquilarisinin, aquilarixanthone, pillion (PLN), and agarotetrol (AGT) are consequently suggested as some of the found hits against AD targets, however, additional experimental validation is required to establish their effectiveness.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"12 ","pages":"230"},"PeriodicalIF":0.0,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11809694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expert Consensus Methods In The Humanities: An Exploration of their Potential.","authors":"Charlotte C S Rulkens, Rik Peels, Lidwine B Mokkink, Tamarinde Haven, Lex Bouter","doi":"10.12688/f1000research.148726.2","DOIUrl":"10.12688/f1000research.148726.2","url":null,"abstract":"<p><strong>Background: </strong>Despite the significant role of consensus and dissensus in knowledge production, formal approaches to consensus are notably less common in the humanities compared to their frequent application in natural, social, and life sciences. This article therefore explores the potential of expert consensus methods in humanities-related research.</p><p><strong>Methods: </strong>In order to do so, an interdisciplinary team of both sciences researchers experienced in consensus methods and researchers familiar with the domain of the humanities and epistemology, conducted a literary review and exchanged their expertise in multiple brainstorm sessions.</p><p><strong>Results: </strong>This resulted in the identification of six key elements of expert consensus methods. It also provided for an overview of different types of expert consensus methods that regularly used in the natural, social, and life sciences: Delphi studies, nominal groups, consensus conferences, and Glaser's state of the art method and illustrative examples from both sciences and humanities-related studies. An overview of possible purposes for applying these methods is provided to identify the research contexts in which these methods have proven their value, which can be extrapolated to humanities related issues for which these methods seem promising.</p><p><strong>Conclusions: </strong>The comparisons and categorisation show that, when focusing on the purposes, there seem to be humanities-related issues that may lend themselves better to structured expert consensus methods than their subject matter and research methods might suggest. When deliberately applied in context chosen by researchers with expertise in a specific humanities domain, expert consensus methods can accelerate epistemic process, enhance transparency, increase replicability, stimulate diversity, and encourage fair processes in humanities research and the application of its findings.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"710"},"PeriodicalIF":0.0,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11754948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring α-ψ-ϕ contractive mapping: novel fixed point theorems in complete b-metric spaces.","authors":"Tamene Raji, Nasir Ali, Maysoon Qousini, Gudeta Hanchalu, Fikadu Tesgera Tolasa, Berhanu Seboka","doi":"10.12688/f1000research.150979.2","DOIUrl":"10.12688/f1000research.150979.2","url":null,"abstract":"<p><p>This paper explores the concept of <math><mi>α</mi> <mo>-</mo> <mi>ψ</mi> <mo>-</mo> <mi>ϕ</mi></math> contractive mappings, contributing to the advancement of self-map extensions and fixed-point theorems within b-metric spaces. We introduce a new class of contractive mappings and demonstrate how they extend traditional contraction principles, offering a broader framework for analyzing fixed points in non-standard spaces. The main result of this study is a generalization of existing fixed-point theorems, supported by comprehensive corollaries, illustrative examples, and rigorous proofs. These findings provide deeper insights into the structure of b-metric spaces and open avenues for further applications in fields such as optimization and machine learning.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"566"},"PeriodicalIF":0.0,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breaking point: Case series of tendon ruptures in Hemodialysis patients.","authors":"Muhammed Ehsan Nazeer, Dr Askhar Haphiz, Dr Muhammed Nazeer, Dr Pradeep Moni, Dr Praveen Muraleedharan","doi":"10.12688/f1000research.155799.2","DOIUrl":"10.12688/f1000research.155799.2","url":null,"abstract":"<p><strong>Introduction: </strong>Spontaneous tendon ruptures in end stage kidney disease patients have the potential to cause long- term morbidity, and timely intervention is required to prevent complications that can severely affect the functional status of the patient.</p><p><strong>Case presentation: </strong>A series of six tendons (two triceps tendons and two bilateral patellar tendons) in three patients with ESKD undergoing hemodialysis is discussed in this case series. Patients were aged 61, 44 and 26 years, and on hemodialysis for 5, 10 and 5 years, respectively.</p><p><strong>Conclusion: </strong>End -stage kidney disease is associated with a multitude of physiological changes, and the musculoskeletal system is no exception to this. Spontaneous tendon rupture is a multifactorial complication of ESKD, with serious implications for mobility and quality of life. As a result, these patients require a multifaceted approach to ensure optimum results and an early return to activity. We report a series of 6 spontaneous tendon ruptures in 3 patients with ESKD at our institution. We would like to outline the methods of repair for each case and further attempt to assess biochemical parameters that may have contributed to the disease process.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1121"},"PeriodicalIF":0.0,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11809646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary Evidence of Human <i>Plasmodium</i> in Domestic Animals from a Malaria-Endemic Region in Indonesia.","authors":"Munirah Munirah, Sitti Wahyuni, Isra Wahid, Firdaus Hamid","doi":"10.12688/f1000research.53946.3","DOIUrl":"10.12688/f1000research.53946.3","url":null,"abstract":"<p><strong>Background: </strong>In Indonesia, malaria incidence is at a high rate despite maximum preventive efforts. Therefore, this study aims to determine the possibility of a <i>Plasmodium</i> reservoir among domestic animals in malaria-endemic areas.</p><p><strong>Methods: </strong>Animal blood was collected using EDTA tubes, then smeared and stained with Giemsa for <i>Plasmodium</i> microscopic identification. About 10 μl of blood was dropped on to a filter paper to capture <i>Plasmodium</i> DNA. Nested PCR was used for parasite molecular detection, while <i>Plasmodium</i> species were identified using the sequenced DNA.</p><p><strong>Results: </strong>A total of 208 and 62 animal blood samples were collected from Gaura village, West Sumba and Fakfak village, West Papua, Indonesia respectively. In total, 32 samples from Gaura contained <i>P. falciparum</i> or <i>P. vivax</i>, while the <i>Plasmodium</i> percentage in buffalo, horse, goat, and dogs were 20.7%, 14.3%, 5.8%, 16.7%, respectively. <i>P. knowlesi</i> was not found in any of the samples, and no other species were detected in 18 pig blood samples.</p><p><strong>Conclusion: </strong>The human <i>Plasmodium</i> DNA in domestic animals within malaria-endemic regions suggests a potential link to the persistence and high prevalence of malaria in these areas. While the findings suggest a potential role of domestic animals in malaria transmission, they remain preliminary and do not definitively establish domestic animals as reservoirs. Further research is necessary to confirm these findings and to better understand the contribution of domestic animals to the transmission dynamics of malaria.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"10 ","pages":"645"},"PeriodicalIF":0.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11809677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotypic and genetic extended spectrum beta lactamase profiles of bacterial isolates from ICU in tertiary level hospital in Kenya.","authors":"Job Mwale, Edwin O Magomere, Brian Maina, Leon Otieno, Frank G Onyambu, Ali Kassim, Lucy Muchiri","doi":"10.12688/f1000research.133298.2","DOIUrl":"10.12688/f1000research.133298.2","url":null,"abstract":"<p><strong>Background: </strong>Bacterial infections in the Intensive Care Units are a threat to the lives of critically ill patients. Their vulnerable immunity predisposes them to developing bacteria-associated sepsis, deteriorating their already fragile health. In the face of increasing antibiotics resistance, the problem of bacterial infection in ICU is worsening. Surveillance of bacterial infections in ICUs and drug resistance will help to understand the magnitude of the problem it poses and inform response strategies. We assessed bacterial infections in ICU setting by identifying prevalent Gram-negative bacterial species and characterized their antibiotic susceptibility patterns.</p><p><strong>Methods: </strong>Cross-sectional samples collected from Kenyatta National Hospital ICU between January and June 2021 were cultured and phenotypic identification of culture-positive samples performed using VITEK 2. Antibiotic susceptibility patterns were determined based on Antimicrobial Susceptibility Testing (AST) results. Cephalosporin-resistant Gram-negative bacteria were assessed by PCR to detect the presence of ESBL genes including ( <i>^bla</i> CTX-M, <i>^bla</i> SHV, <i>^bla</i> TEM, <i>^bla</i> OXA).</p><p><strong>Results and discussion: </strong>Out of the 168 Gram-negative isolates, <i>Acinetobacter baumanii</i> was the most abundant (35%). Other isolates that were present at frequencies more than 15% are <i>Klebsiella pneumoniae</i> and <i>Escherichia. coli. A. baumaniii</i> is known to be a notorious bacterium in ICU due to its multidrug resistance nature. Indeed, <i>A. baumanii</i> isolates from Kenyatta National Hospital showed significantly high level of phenotypic resistance. Concordant with the high level of phenotypic resistance, we found high carriage of the ESBL genes among the isolates analysed in this study. Moreover, majority of isolates harboured all the four ESBL genes.</p><p><strong>Conclusion: </strong>A high rate of phenotypic and genetic resistance was detected among the tested isolates. Resistance to cephalosporins was primarily driven by acquisition of the ESBL genes. The high prevalence rate of ESBL genes in ICU bacterial isolates shown in this study has a important implication for ICU patient management and general antibiotics use.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"12 ","pages":"469"},"PeriodicalIF":0.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11754949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxygen as obturation biomaterial in endodontic treatment: development of novel membranous dental restoration system.","authors":"Didi Wahyudi, Citra Kusumasari","doi":"10.12688/f1000research.132479.2","DOIUrl":"10.12688/f1000research.132479.2","url":null,"abstract":"<p><p>Complexities in obturation and difficulties in disinfection represent significant issues that render endodontic treatment notably time-consuming. A new perspective is essential to reduce both working time and address these two challenges. To date, none of the established techniques for root canal obturation can assure a perfect seal. Solid materials are not easily manipulated to hermetically fill the intricate branches of the root canal system. Concurrently, anaerobic and facultative anaerobic bacteria, particularly <i>Enterococcus faecalis</i>, are predominant in discussions surrounding endodontic infections. Numerous studies have demonstrated that achieving complete disinfection of <i>Enterococcus faecalis</i> is exceedingly difficult, even with the use of irrigating solutions that possess strong antibacterial properties. Under anaerobic conditions, the invasion efficiency of facultative anaerobes is heightened. If irrigation and disinfection fail to entirely eliminate anaerobes and facultative anaerobes, a novel strategy is required to address the bacteria that persist within the root canal. Oxygen can easily permeate the root canal system, eradicate anaerobes, and inhibit facultative anaerobes from becoming pathogenic. Therefore, employing oxygen as a biomaterial for obturation following appropriate cleaning and shaping procedures is anticipated to address the two primary endodontic issues. This article aims to explore a new potential concept for a dental restoration system that utilizes an oxygen-permeable membrane to reduce the time required for endodontic treatment. The membrane is positioned at the orifice of a duct designed to connect the entire root canal system with ambient air outside the restoration. The function of the membrane is somewhat analogous to the masks used during the COVID-19 pandemic, as it allows for the circulation of oxygen while preventing the passage of fluids, debris, and microorganisms. We hypothesize that the oxygen circulating within the root canal system will also function as a continuously renewing antimicrobial agent.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"12 ","pages":"380"},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11584453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurodiversity in Saudi Arabia: Towards quality education and reduced inequalities.","authors":"Ahmed Yahya Almakrob, Ahmed Alduais, Alex S M Mhone, Borey Be","doi":"10.12688/f1000research.155002.2","DOIUrl":"10.12688/f1000research.155002.2","url":null,"abstract":"<p><p>Traditional educational frameworks in Saudi Arabia have historically adopted a deficit-based approach to special education, potentially overlooking the benefits of neurodiversity. As global educational paradigms shift toward inclusive practices, examining the alignment of Saudi special education laws with neurodiversity principles becomes crucial. This content analysis study aimed to explore the existing literature on special education in Saudi Arabia to ascertain whether the laws and policies support or hinder the practice of neurodiversity, a concept that is gaining international recognition but remains nascent in Saudi Arabia. A systematic literature search was performed in Web of Science and Scopus, yielding 21 relevant studies after screening and application of inclusion criteria. A content analysis was conducted, focusing on the categorization of data relevant to special education laws and their implications for neurodiversity. The analysis identified seven key categories, including Implementation of Inclusive education and transition services, that reflect the current state of special education laws in relation to neurodiversity. A conceptual model was developed, illustrating the potential of special education laws to both support and impede neurodiversity in Saudi Arabia and potentially worldwide.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1062"},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors contributing to persistent shoulder pain after arthroscopic rotator cuff repair: Protocol for a scoping review.","authors":"Anupama Prabhu B, G Arun Maiya, Vivek Pandey, Kiran K V Acharya, Prabu Raja G, James Elliott M, Mira Meeus","doi":"10.12688/f1000research.156193.2","DOIUrl":"10.12688/f1000research.156193.2","url":null,"abstract":"<p><strong>Introduction: </strong>Rotator cuff (RC) tears are the most common and disabling musculoskeletal ailments among patients with shoulder pain. Although most individuals show improvement in function and pain following arthroscopic rotator cuff repair (ARCR), a subgroup of patients continue to suffer from persistent shoulder pain following the surgical procedure. Identifying these factors is important in planning preoperative management to improve patient outcomes.</p><p><strong>Objective: </strong>This scoping review aims to identify biological factors, psychological factors, and social determinants of health contributing to the development of persistent pain in individuals after the ARCR procedure.</p><p><strong>Inclusion criteria: </strong>All prospective and retrospective longitudinal studies reporting the risk factors contributing to persistent pain three months or longer after the ARCR surgery will be considered for this scoping review.</p><p><strong>Methods: </strong>Our review will adhere to the Joanna Briggs Institute (JBI) scoping review methodology. Four electronic databases PubMed, CINAHL, Embase, and Scopus will be searched for studies in the English language. Additional studies can be found by conducting a citation analysis of the included studies. Title and abstract screening will be performed by two independent reviewers following the inclusion criteria, a third reviewer will be consulted about any differences. Next, full-text screening will be conducted, and the remaining search results will be reviewed to extract data, as well as to synthesize findings from all research. An overview of findings will be depicted in tabular format accompanied by a narrative summary of various factors contributing to persistent pain.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"13 ","pages":"1236"},"PeriodicalIF":0.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11715645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of mortality for blunt trauma patients in intensive care: A retrospective cohort study.","authors":"Michael Jennings, James Booker, Amy Addison, Rebecca Egglestone, Ahilanandan Dushianthan","doi":"10.12688/f1000research.138364.1","DOIUrl":"10.12688/f1000research.138364.1","url":null,"abstract":"<p><strong>Background: </strong>Major trauma places substantial demand on critical care services, is a leading cause of death in under 40-year-olds and causes significant morbidity and mortality across all age groups. Various factors influence patient outcome and predefining these could allow prognostication. The aim of this study was to identify predictors of mortality from major trauma in intensive care.</p><p><strong>Methods: </strong>This was a retrospective study of adult trauma patients admitted to general intensive care between January 2018 and December 2019. We assessed the impact on mortality of patient demographics, patterns of injury, injury scores (Glasgow Coma Score (GCS), Charlson's comorbidity index (CCI), Acute Physiology and Health Evaluation II (APACHE II), Injury Severity Score (ISS) and Probability of Survival Score (Ps19)), number of surgeries and mechanism of injury using logistic regression.</p><p><strong>Results: </strong>A total of 414 patients were included with a median age of 54 years (IQR 34-72). Overall mortality was 18.6%. The most common mechanism of injury was traffic collision (46%). Non-survivors were older, had higher ISS scores with lower GCS on admission and lower probability of survival scores. Factors independently predictive of mortality were age 70-80 (OR 3.267, p = 0.029), age >80 (OR 27.043, p < 0.001) and GCS < 15 (OR 8.728, p < 0.001). Ps19 was the best predictor of mortality (p <0.001 for each score category), with an AUROC of 0.90.</p><p><strong>Conclusions: </strong>The significant mortality predictors were age, fall from <2 metres, injury of head or limbs, GCS <15 and Ps19. Contrary to previous studies, CCI and APACHE II did not significantly predict mortality. Although Ps19 was found to be the best current prognostic score, trauma prognostication would benefit from a single validated scoring system incorporating both physiological variables and injury patterns.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":" ","pages":"974"},"PeriodicalIF":0.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11628930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46027779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}