F1000Research最新文献

{"title":"Market intelligence for exporting agricultural products to foreign markets: A PRISMA-based bibliometric and systematic review.","authors":"Antony Altamirano-Gonzales, Rogger Orlando Morán-Santamaría","doi":"10.12688/f1000research.175062.2","DOIUrl":"10.12688/f1000research.175062.2","url":null,"abstract":"<p><strong>Background: </strong>International trade in agri-food products faces growing challenges linked to price volatility, trade barriers and information asymmetries, factors that reduce the competitiveness of exporting companies. In this scenario, market intelligence (MI) is positioned as a fundamental tool for strengthening international marketing processes, as it enables the systematic collection and analysis of information to support strategic decision-making.</p><p><strong>Methods: </strong>This study employs a cross-sectional, descriptive, and non-experimental design based on a bibliometric and systematic analysis of the literature. A mixed methodology was used, integrating qualitative content synthesis with bibliometric indicators.</p><p><strong>Results: </strong>The results show that scientific production related to market intelligence has experienced particularly notable growth since 2018, with a predominant participation of countries such as the United States, China and the United Kingdom. The analysis identified a three-part structure consisting of the conceptual foundations of MI, its strategic applications in the field of agro-exports, and its documented effects on export performance. The evidence reviewed confirms that MI contributes to strengthening international competitiveness by reducing uncertainty and guiding strategic decision-making within companies.</p><p><strong>Conclusions: </strong>Despite the benefits associated with the use of market intelligence in the agro-export environment, its adoption remains limited, especially in Latin America, where technological and institutional gaps persist that hinder its full implementation. The available evidence suggests that MI is a strategic resource for improving export performance, although significant efforts are still required to expand its use and consolidate its contribution to the competitive development of the sector.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"15 ","pages":"316"},"PeriodicalIF":0.0,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13579032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148988828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression status transition of  <i>NOTCH1</i> accompanies chromatin remodeling in human early retinal progenitor cells.","authors":"Yoshitoku Watabe, Sakurako Kobayashi, Takahiro Nakayama, Satoru Takahashi, Masaharu Yoshihara","doi":"10.12688/f1000research.159630.5","DOIUrl":"10.12688/f1000research.159630.5","url":null,"abstract":"<p><strong>Background: </strong>Notch signaling, especially via the Notch1 receptor, is involved in normal eye development by maintaining retinal progenitor cell state before their differentiation, although the regulatory mechanism of fine-tuned Notch1 expression is unclear.</p><p><strong>Methods: </strong>We re-analyzed publicly available human fetal retina single-cell RNA/ATAC-seq data at days 59, 74, and 78, using Seurat/Signac pipelines.</p><p><strong>Results: </strong>We observed <i>NOTCH1</i> expression in retinal progenitor cells, which diminished at later stages of differentiation. Integration of single-cell RNA-seq and ATAC-seq revealed a decrease in chromatin accessibility at the <i>NOTCH1</i> locus, accompanied by a decrease in its mRNA expression during differentiation into bipolar cells, horizontal cells, or retinal ganglion cells. Importantly, those chromatin remodeling regions contained the binding motifs of the <i>RAX</i> transcription factor, which is essential for retinal progenitor cells, Muller glia, and cones. This result suggested that the regulation of <i>NOTCH1</i> expression might be achieved by chromatin remodeling at the <i>NOTCH1</i> locus, although single-cell RNA-seq analysis suggested that <i>RAX</i> expression regulation might also contribute to <i>NOTCH1</i> expression.</p><p><strong>Conclusions: </strong>By analyzing retinal cell differentiation, this study identified a putative <i>RAX</i> binding site in the <i>NOTCH1</i> locus and raised the possibility that <i>NOTCH1</i> expression could be regulated by chromatin remodeling.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"31"},"PeriodicalIF":0.0,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13637476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Influencing Customer Satisfaction and Behavioral Intention in Local Food Tourism: A Structural Equation Modeling Approach.","authors":"Warach Madhyamapurush","doi":"10.12688/f1000research.179249.5","DOIUrl":"10.12688/f1000research.179249.5","url":null,"abstract":"<p><p>Local food tourism (LFT) significantly impacts destination experiences by shaping tourists' perceptions, satisfaction, and post-visit behavior. Despite the growing importance of local food tourism, there remains limited empirical understanding of how experiential attributes influence customer satisfaction and behavioral intention (BI). This research uses a thorough Structural Equation Modeling (SEM) framework to examine the variables affecting customer satisfaction (CS) and behavioral intention (BI) in LFT. A total of 380 valid responses were obtained from a quantitative cross-sectional survey of visitors who sampled local cuisine at particular Thai culinary sites. A structured questionnaire measured six exogenous constructs: food quality (FQ), Authenticity (AU), service quality (SQ), physical environment (PE), cultural experience (CE), and perceived value (PV) along with CS as a mediator and BI (revisit intention and Consumer referral behavior) as the endogenous outcome. Cronbach's alpha, composite reliability (CR), average variance extracted (AVE), and discriminant validity using the Fornell-Larcker criterion were used to evaluate reliability and validity. Utilizing confirmatory factor analysis (CFA), the measurement model was validated. The findings suggest that CS is strongly and favorably influenced by FQ, AU, CE, and PV. The association between experience qualities and loyalty outcomes is partially mediated by CS, which also strongly predicts BI. A well-fitting measurement model is indicated by the model's acceptable goodness-of-fit indices, which include a Comparative Fit Index (CFI) of 0.952, Tucker-Lewis Index (TLI) of 0.945, Root Mean Square Error of Approximation (RMSEA) of 0.056, and Standardized Root Mean Square Residual (SRMR) of 0.048. The findings provide practical insights for enhancing tourist loyalty through authentic and high-quality culinary experiences.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"15 ","pages":"596"},"PeriodicalIF":0.0,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13560856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148955304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancement of Tribological and Mechanical Properties via Soda-Lime Silica Glass Reinforced Al-Mg-Zn Matrix Composite.","authors":"Babuli Chandra Kar, Sambit Kumar Mohapatra, Pushkar Jha","doi":"10.12688/f1000research.183177.2","DOIUrl":"10.12688/f1000research.183177.2","url":null,"abstract":"<p><strong>Background: </strong>A large volume of waste Soda-Lime Silica (SLS) glass has become a major environmental concern due to improper disposal and limited recycling utilization. At the same time, the increasing industrial demand for high-strength-to-weight ratio materials has opened opportunities for incorporating SLS glass as reinforcement in aluminium matrix composites.</p><p><strong>Methods: </strong>In this study, a novel aluminium, magnesium, zinc and SLS glass hybrid metal matrix composite (MMC) was developed, using an ultrasonic vibration-supported stir-squeeze casting process. Glass reinforcements of 1, 2, 4, and 5 wt.% were incorporated to investigate their influence on the microstructural, mechanical, and tribological properties of the composite. The Scanning Electron Microscopy (SEM), Strain Rate Jump (SRJ) Gleeble compression test, micro-hardness, impact, pin-on-disc dry sliding wear test, wear morphology were conducted for comprehensive characterization of the cast specimen.</p><p><strong>Results: </strong>SEM pictures revealed the uniform dispersion and strong matrix-reinforcement bonding. The hardness of the fabricated composite increased by ~ 23% as the reinforcement content increased from 1 to 5 wt.%, whereas the toughness reduced by ~ 46%. The SRJ test conducted using a Gleeble thermo-mechanical simulator clearly illustrates lower compressive strength for the composites reinforced with 4 wt.% and 5 wt.% SLS glass, whereas the sample having 2 wt.% reinforcement exhibited the highest strain-rate sensitivity. The 2 wt.% composite exhibited the lowest wear during the pin-on-disc dry sliding wear test, which can be attributed to the synergistic effects of Zn and Mg, along with the strengthening imparted by the well-dispersed glass particles. At higher reinforcement percentages, micro-fracturing and wear damage became more pronounced.</p><p><strong>Conclusions: </strong>Overall, the composite reinforced with 2 wt.% SLS glass offered the best balance of strength, toughness, and wear resistance. By valorising waste SLS glasses, these hybrid composites can be utilized for lightweight, structural and wear-critical applications, thereby advancing sustainable manufacturing.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"15 ","pages":"1181"},"PeriodicalIF":0.0,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13560067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148955203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cataloguing and Theorising Open Research Practices in the Arts, Humanities and Social Sciences: Problematising and Diversifying 'Open Science'.","authors":"Jenni Adams, Miranda Barnes, Samuel Moore, Stephen Pinfield","doi":"10.12688/f1000research.178353.2","DOIUrl":"10.12688/f1000research.178353.2","url":null,"abstract":"<p><strong>Background: </strong>Discourses of 'Open Science' have been criticised for privileging the quantitative and positivist methodologies of science, technology, engineering and mathematics (STEM) research at the expense of qualitative, interpretive, critical-theoretical, practice-based, and other forms of research more common in the arts, humanities and social sciences (AHSS).</p><p><strong>Methods: </strong>In this article, which emerged from a work component of the MORPHSS (Materialising Open Research Practices in the Humanities and Social Sciences) project, we document the process, outcomes and practical implications of work to develop a catalogue of open research practices in these disciplines, which proceeded via a wide-ranging literature review followed by targeted desk research and a conceptual mapping exercise.</p><p><strong>Results: </strong>Key findings include the fact that open research practices in AHSS are diverse, extending beyond the suite of practices emphasised within dominant accounts of Open Science. We identify among these practices a range of forms of openness including those focused on mobilising the involvement and expert knowledge of diverse participants and communities.</p><p><strong>Conclusions: </strong>Presenting a typology of forms of openness in AHSS that is consistent with the epistemic logics of these disciplines, we conclude that openness in AHSS is highly situated and context-dependent, as well as resisting quantification and binary measurement. Drawing on these conclusions, we offer a series of recommendations for institutions, open research monitoring initiatives, funders, publishers, learned societies and researchers to enhance the inclusivity of their policy and practice around openness.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"15 ","pages":"515"},"PeriodicalIF":0.0,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13287985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148316472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coexistence Analysis of 5G C-Band Indoor Deployments and Fixed Satellite Service (FSS) in Malaysia.","authors":"Abdulmajeed Al-Jumaily, Qasim Khalaf, Mohammed Abbas, Yaseein Hussein, Víctor Jiménez, Aduwati Sali, Saba Aljumaili, Dhiya Al-Jumeily","doi":"10.12688/f1000research.175496.2","DOIUrl":"10.12688/f1000research.175496.2","url":null,"abstract":"<p><p>Several satellite services, including the Fixed Satellite Service (FSS), rely on the C-Band (3. 4 - 4. 2 GHz), which provides wide coverage and high availability despite weather effects. As a mid-band spectrum ideal for 5G, its allocation to cellular networks raises interference concerns, potentially disrupting satellite services and causing a significant economic impact. This study presents an empirical, measurement-based 5G propagation assessment and an interference investigation with 5G cellular networks operating below the 6 GHz band in the optimization of exclusion zones for 5G and FSS scenarios, with the aim of fine-tuning the exclusion zone and identifying better coexistence conditions between the two systems. We provide an extensive 5G-cellular downlink analysis that discusses, as part of the coexistence context, the potential for Low-Noise Block (LNB) saturation at the FSS Earth station receiver. Moreover, we deployed a real indoor 5G cellular network for measurement, in which high-gain receiving antennas were positioned at various indoor and outdoor locations to capture the downlink signal radiated by the 5G base-station transmitter within the proposed site. Additionally, a spectrum analyzer was used to examine the power signal received in contrast to the data signal acquired for the proposed projects. Across the indoor measurement points, the received power decreased with distance, reaching approximately -74.02 dBm at 40 m, and no measurable elevation of the FSS signal was observed at the MEASAT earth station located 3 km away. The results of this research indicate that spectrum regulators and other relevant parties will be affected by the potential implementation of 5G cellular networks in C-band operational FSS Earth station receivers. The research additionally proposes and evaluates methods that could facilitate the harmonious coexistence of both systems, like disabling significant emitters or diminishing their transmission capacity.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"15 ","pages":"916"},"PeriodicalIF":0.0,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13562934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148955011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Teachers' Perceptions of the PIL-SMART Model: A Semlj Analysis of its Influence on Science and Environmental Literacy in Early Childhood Education.","authors":"Nita Priyanti, Chandra Apriyansyah, Tedy Andrian","doi":"10.12688/f1000research.181997.2","DOIUrl":"10.12688/f1000research.181997.2","url":null,"abstract":"<p><strong>Background: </strong>Science and environmental literacy are foundations for children's scientific thinking and ecological awareness. However, integrated learning approaches connecting these competencies remain limited in early childhood education. This study examined associations among teachers' perceptions of Project-Inquiry Learning integrating Science, Mathematics, Art, Religion, and Technology (PIL-SMART), teacher-rated science literacy, and teacher-rated environmental literacy.</p><p><strong>Methods: </strong>A cross-sectional survey involved 200 teachers from 125 early childhood education institutions in Bekasi City, West Java, Indonesia. Participants were selected through purposive sampling. Data were collected using a five-point Likert-scale questionnaire measuring three constructs. Reliability analysis, Confirmatory Factor Analysis, and Structural Equation Modeling were conducted using Jamovi with the SEMLj module. Following measurement-model evaluation, 28 indicators were retained: ten for PIL-SMART, nine for science literacy, and nine for environmental literacy.</p><p><strong>Results: </strong>The model demonstrated fit, χ ² (347) = 408, p = 0.014, CFI = 0.980, TLI = 0.978, RMSEA = 0.030 (95% CI: 0.014-0.041), and SRMR = 0.049. PIL-SMART perceptions were positively associated with science literacy (β = 0.744, p < 0.001) and environmental literacy (β = 0.266, p = 0.006). Science literacy was positively associated with environmental literacy (β = 0.517, p < 0.001). The indirect association through science literacy was significant (β = 0.384, p < 0.001), indicating partial mediation.</p><p><strong>Conclusion: </strong>Favourable perceptions of PIL-SMART were associated with higher teacher ratings of children's science and environmental literacy. Because this cross-sectional study used teacher-reported measures, the findings indicate associations rather than causal effects. Future studies should use child assessments, classroom observations, and longitudinal or experimental designs.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"15 ","pages":"1034"},"PeriodicalIF":0.0,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13560012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148955079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation and Clinical Relevance of Plan Quality Indices in Intracavitary Brachytherapy for Cervical Cancer.","authors":"Abhishek Krishna, Juvie Leona Lobo, Pooja Ms, Bharat Sai Makkapati, Athiyamaan Ms, Challapalli Srinivas, Sourjya Banerjee, Johan Sunny, Paul Simon, Dilson Lobo","doi":"10.12688/f1000research.166604.2","DOIUrl":"10.12688/f1000research.166604.2","url":null,"abstract":"<p><strong>Background: </strong>Cervical cancer remains to be a significant health concern globally, with India contributing to nearly one-quarter of cases worldwide. Intracavitary brachytherapy (ICBT) combined with external beam radiotherapy (EBRT) is the standard of care, optimizing tumour dose while sparing normal tissues. Plan quality indices such as Dose Homogeneity Index (DHI), Overdose Index (OI), Dose Non-uniformity Ratio (DNR), and Conformity Index (COIN) are crucial in evaluating treatment plans, yet their predictive clinical relevance remains underexplored.</p><p><strong>Methodology: </strong>In this Retrospective study, 84 patients with histologically confirmed cervical cancer undergoing definitive chemoradiation followed by CT-based HDR ICBT (Co-60) were evaluated. Plan indices were calculated per ICRU 89 and GEC-ESTRO guidelines. Correlation with tumour response (RECIST v1.1), toxicity (≥ grade 2 bladder/rectal), and clinical factors (FIGO stage, HRCTV volume, EQD2, BED, treatment duration) was assessed using t-tests, regression analyses, and Pearson's correlation.</p><p><strong>Results: </strong>Mean DHI was 0.403; OI 0.358; DNR 0.594; COIN 0.636. Higher DHI (p=0.019) and lower OI (p=0.004) were associated with tumour response; DNR and COIN were not significant. No plan index predicted ≥ grade 2 bladder or rectal toxicity. COIN correlated poorly with other indices. Multiple regression showed no consistent predictors of dosimetric indices. Logistic regression did not establish any index as a definitive predictor of 3-month response.</p><p><strong>Conclusion: </strong>Plan quality indices provide useful quantitative insights into dose distribution in High dose rate intracavitary brachytherapy for cervical cancer. In this study, DHI and OI showed an association with early tumour response, while no significant correlation was observed between plan indices and treatment-related toxicity.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"14 ","pages":"882"},"PeriodicalIF":0.0,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13560041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148955261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baseline Extracellular HMGB-1 Levels Associated with Induction Chemotherapy Response in Adult Acute Myeloid Leukemia.","authors":"Resti Mulya Sari, Lyana Setiawan, Damai Santosa, Syarifah Dewi, Melva Louisa, Ikhwan Rinaldi, Noorwati Sutandyo","doi":"10.12688/f1000research.183970.2","DOIUrl":"10.12688/f1000research.183970.2","url":null,"abstract":"<p><strong>Background: </strong>Treatment response in acute myeloid leukemia (AML) is influenced by multiple biological and molecular mechanisms. High-mobility group box 1 (HMGB-1) is involved in inflammation, autophagy, apoptosis, and immunogenic cell death. This study evaluated associations of baseline circulating miR-181a-3p, miR-181b-5p, ATM, ATR, and HMGB-1 with successful induction response in adults with newly diagnosed AML.</p><p><strong>Methods: </strong>This prospective cohort study was conducted at two referral hospitals in Jakarta, Indonesia. Adults with newly diagnosed AML receiving standard D3A7 induction chemotherapy were enrolled consecutively. Baseline miR-181a-3p and miR-181b-5p were quantified using digital polymerase chain reaction, whereas ATM, ATR, and HMGB-1 were measured using enzyme-linked immunosorbent assays before chemotherapy. Successful induction response was assessed by clinical and bone marrow evaluation after induction. Receiver operating characteristic analysis determined an exploratory HMGB-1 cut-off. Associations were evaluated using relative risks (RRs) with 95% confidence intervals (CIs).</p><p><strong>Results: </strong>Among 102 patients initiating induction chemotherapy, 25 died during induction or early post-induction care. The biomarker-evaluable cohort comprised 71 patients, of whom 40 (56.3%) achieved a successful response. Baseline miR-181a-3p, miR-181b-5p, ATM, and ATR were not significantly associated with response. HMGB-1 yielded an area under the curve of 0.615 (95% CI, 0.480-0.749). The exploratory cut-off was 28.59 pg/mL, with 65.0% sensitivity and 61.3% specificity. Low HMGB-1 was associated with a lower probability of successful response (RR, 0.620; 95% CI, 0.394-0.975; p = 0.038). In the final clinical-biomolecular model, high HMGB-1 remained associated with successful response after adjustment for platelet count and ATR (adjusted RR, 1.666; 95% CI, 1.092-2.541; p = 0.018).</p><p><strong>Conclusion: </strong>Low baseline circulating HMGB-1 was associated with a lower probability of successful induction response in the biomarker-evaluable adult AML cohort. Given its modest discriminatory performance and internally derived cut-off, HMGB-1 should be considered an exploratory complementary biomarker requiring external validation and serial evaluation.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"15 ","pages":"1143"},"PeriodicalIF":0.0,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13562947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148955316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Mediating Role of Knowledge Sharing in the Relationship Between Transformational Leadership, Organizational Culture, and Nursing Innovation in the Makkah Health Cluster.","authors":"Khadija Lafi Aljarary, Hafizah Che Hassan","doi":"10.12688/f1000research.186053.2","DOIUrl":"10.12688/f1000research.186053.2","url":null,"abstract":"<p><strong>Background: </strong>Nursing innovation is essential for improving healthcare quality, patient safety, and organizational performance. Although transformational leadership and organizational culture have been associated with innovation, the mechanisms linking these organizational factors with nursing innovation remain insufficiently understood, particularly within integrated healthcare systems in Saudi Arabia. This study examined the relationships of transformational leadership and organizational culture with nursing innovation and investigated the mediating role of knowledge sharing among registered nurses in the Makkah Health Cluster, Saudi Arabia.</p><p><strong>Methods: </strong>A quantitative analytical cross-sectional study was conducted among 531 registered nurses recruited using proportionate stratified random sampling from six hospitals within the Makkah Health Cluster. Data were collected using standardized self-administered questionnaires assessing transformational leadership, organizational culture, knowledge sharing, and nursing innovation. Partial Least Squares Structural Equation Modelling (PLS-SEM) was used to evaluate the measurement and structural models and examine direct and indirect relationships among the study constructs.</p><p><strong>Results: </strong>Transformational leadership was positively associated with nursing innovation (β = 0.313, <i>p</i> < 0.001) and knowledge sharing (β = 0.573, <i>p</i> < 0.001). Organizational culture was also positively associated with nursing innovation (β = 0.249, <i>p</i> < 0.001) and knowledge sharing (β = 0.340, <i>p</i> < 0.001). Knowledge sharing was positively associated with nursing innovation (β = 0.345, <i>p</i> < 0.001). Knowledge sharing demonstrated complementary partial mediation in the relationships between transformational leadership and nursing innovation (indirect β = 0.198, <i>p</i> < 0.001) and between organizational culture and nursing innovation (indirect β = 0.117, <i>p</i> < 0.001). The model explained 63.1% of the variance in knowledge sharing and 62.0% of the variance in nursing innovation.</p><p><strong>Conclusions: </strong>Transformational leadership, organizational culture, and knowledge sharing were significantly associated with nursing innovation, with knowledge sharing representing a complementary pathway linking leadership and organizational culture with innovative nursing behaviour. Healthcare organizations may benefit from integrating leadership development, supportive organizational cultures, and knowledge-sharing strategies to create conditions conducive to nursing innovation and continuous quality improvement within the context of Saudi healthcare transformation.</p>","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"15 ","pages":"1173"},"PeriodicalIF":0.0,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13560043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148955060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}