Dengue infection during pregnancy and the occurrence of pathological neonatal outcome: a systematic review and meta-analysis.

Q2 Pharmacology, Toxicology and Pharmaceutics

F1000Research Pub Date : 2025-08-26 eCollection Date: 2024-01-01 DOI:10.12688/f1000research.158890.3

Evelyn Del Socorro Goicochea-Ríos, Nelida Milly Otiniano, Lola Del Carmen Rojas-Infantas, Víctor Raú Ocaña-Gutiérrez, Néstor Iván Gómez-Goicochea

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引用次数: 0

Abstract

Background: Dengue infection during pregnancy increases the risk of maternal and neonatal complications; therefore, the objective of this research is to determine these outcomes and describe the clinical manifestations of the infection.

Methods: A systematic review of studies published in PubMed, MEDLINE, LILACS, Web of Science, Scopus and thesis repositories published between 2013 and October 2023 was performed. DeCS and MeSH dengue and maternal-neonatal outcome were used. Thirteen studies were selected and the New Castle-Ottawa scale was used to assess their quality. Mantel-Haenszel hazard ratios were calculated to report the overall effect size using random-effects models. All analyses were performed in Rev Man 5.4.1.

Results: The 13 studies involved a population of 18,724 pregnant women, with cohorts ranging from 25 to 17,673 pregnant women. The most frequent outcomes in the pregnant women were cesarean section and postpartum hemorrhage, and in the newborns, preterm delivery and low birth weight. According to the New Castle-Ottawa scale, six studies were considered low risk and seven studies moderate risk. Dengue is a risk factor for postpartum hemorrhage (OR: 2.23 IC 0.24 - 20.38), premature rupture of membranes (OR: 1.04 IC 0.55-1.97) and cesarean section (OR: 1.39 IC 0.80 - 2.41). It could not be concluded that dengue is a risk factor for the neonatal outcomes studied. The clinical picture of pregnant women with dengue was predominantly fever, abdominal pain, vomiting and nausea, anemia, dyspnea and myalgia.

Conclusions: Pregnancy-related changes in the immune, cardiovascular and coagulation systems, among others, increase the probability of adverse maternal and neonatal outcomes in case of DENV infection, such as postpartum hemorrhage, premature rupture of membranes, cesarean section, low birth weight and preterm delivery. Pregnant women should be considered a population at risk and should be included in dengue control, diagnosis and treatment policies.

查看原文本刊更多论文

妊娠期登革热感染与新生儿病理性结局的发生：一项系统回顾和荟萃分析。

背景：孕期感染登革热会增加孕产妇和新生儿并发症的风险；因此，本研究的目的是确定这些结果并描述感染的临床表现。方法：系统回顾2013年至2023年10月在PubMed、MEDLINE、LILACS、Web of Science、Scopus和论文库中发表的研究。采用DeCS和MeSH进行登革热和母婴预后分析。我们选择了13项研究，并使用New Castle-Ottawa量表来评估它们的质量。使用随机效应模型计算Mantel-Haenszel风险比以报告总体效应大小。所有分析均在Rev Man 5.4.1中进行。结果：13项研究涉及18,724名孕妇，队列从25到17,673名孕妇。孕妇最常见的结局是剖宫产和产后出血，新生儿最常见的结局是早产和低出生体重。根据纽卡斯尔-渥太华量表，6项研究被认为是低风险，7项研究被认为是中度风险。登革热是产后出血（OR: 2.23 IC 0.24 - 20.38）、胎膜早破（OR: 1.04 IC 0.55-1.97）和剖宫产（OR: 1.39 IC 0.80 - 2.41）的危险因素。不能断定登革热是所研究新生儿结局的一个危险因素。孕妇登革热的临床表现主要为发热、腹痛、呕吐和恶心、贫血、呼吸困难和肌痛。结论：妊娠相关的免疫、心血管和凝血系统等改变，增加了DENV感染后发生产后出血、胎膜早破、剖宫产、低出生体重和早产等孕产妇和新生儿不良结局的可能性。应将孕妇视为高危人群，并将其纳入登革热控制、诊断和治疗政策。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

F1000Research Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

5.00

自引率

0.00%

发文量

1646

审稿时长

1 weeks

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