Experimental Aging Research最新文献_第6页

Hippocampal Subregions Volume and Texture for the Diagnosis of Mild Cognitive Impairment. 用于诊断轻度认知障碍的海马亚区体积和纹理。

IF 1.4 4区医学

Experimental Aging Research Pub Date : 2025-01-01 Epub Date: 2024-02-15 DOI: 10.1080/0361073X.2024.2313940

Tongpeng Chu, Yajun Liu, Bin Gui, Zhongsheng Zhang, Gang Zhang, Fanghui Dong, Jianli Dong, Shujuan Lin

{"title":"Hippocampal Subregions Volume and Texture for the Diagnosis of Mild Cognitive Impairment.","authors":"Tongpeng Chu, Yajun Liu, Bin Gui, Zhongsheng Zhang, Gang Zhang, Fanghui Dong, Jianli Dong, Shujuan Lin","doi":"10.1080/0361073X.2024.2313940","DOIUrl":"10.1080/0361073X.2024.2313940","url":null,"abstract":"The aim was to examine the diagnostic efficacy of hippocampal subregions volume and texture in differentiating amnestic mild cognitive impairment (MCI) from normal aging changes. Ninety MCI subjects and eighty-eight well-matched healthy controls (HCs) were selected. Twelve hippocampal subregions volume and texture features were extracted using Freesurfer and MaZda based on T1 weighted MRI. Then, two-sample t-test and Least Absolute Shrinkage and Selection Operator (LASSO) regression were developed to select a subset of the original features. Support vector machine (SVM) was used to perform the classification task and the area under the curve (AUC), sensitivity, specificity and accuracy were calculated to evaluate the diagnostic efficacy of the model. The volume features with high discriminative power were mainly located in the bilateral CA1 and CA4, while texture feature were gray-level non-uniformity, run length non-uniformity and fraction. Our model based on hippocampal subregions volume and texture features achieved better classification performance with an AUC of 0.90. The volume and texture of hippocampal subregions can be utilized for the diagnosis of MCI. Moreover, we found that the features that contributed most to the model were mainly textural features, followed by volume. These results may guide future studies using structural scans to classify patients with MCI.","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":" ","pages":"125-136"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139734803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examining the Utility of a Multiple Group Membership Intervention for Alleviating the Effects of Age-Based Stereotype Threat on Older adults' Memory Performance. 研究多重群体成员干预对减轻年龄刻板印象威胁对老年人记忆力影响的作用。

IF 1.4 4区医学

Experimental Aging Research Pub Date : 2025-01-01 Epub Date: 2024-01-26 DOI: 10.1080/0361073X.2024.2306457

Giverny J Parker, Catherine Haslam, Jaimee Stuart, David H K Shum, Tamara Ownsworth

{"title":"Examining the Utility of a Multiple Group Membership Intervention for Alleviating the Effects of Age-Based Stereotype Threat on Older adults' Memory Performance.","authors":"Giverny J Parker, Catherine Haslam, Jaimee Stuart, David H K Shum, Tamara Ownsworth","doi":"10.1080/0361073X.2024.2306457","DOIUrl":"10.1080/0361073X.2024.2306457","url":null,"abstract":"This study examined the effectiveness of a multiple group membership intervention for reducing the negative effects of age-based stereotype threat (ABST) on older adults' objective memory performance and subjective memory concerns. Healthy older adults (N = 68) were randomly allocated to an ABST + threat-removal (ABST+TR) or ABST + active-control (ABST+AC) condition. After activating ABST, the ABST+TR condition completed a group-listing task and the ABST+AC condition completed a meal-listing task. Participants then completed the Rey Auditory Verbal Learning Test (RAVLT) and Everyday Memory Questionnaire - Revised. One significant difference was found in memory performance between conditions; specifically, after controlling for age, gender, and number of items listed, those in the ABST+TR condition performed significantly better on the RAVLT memory interference trial. Further, listing a greater number of group memberships was associated with better memory performance in the ABST+TR condition. No significant difference was found in subjective memory concerns between the ABST+TR condition and the ABST+AC condition. Overall, the current findings indicated that raising the salience of multiple group memberships offered limited protection for older adults' cognitive test performance in the context of ABST.","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":" ","pages":"103-124"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139566943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COPD, Dietary Fiber Intake, and Cognitive Performance in Older Adults: A Cross-Sectional Study from NHANES 2011-2014. 慢性阻塞性肺病、膳食纤维摄入量和老年人认知能力:来自NHANES 2011-2014的横断面研究

IF 1.4 4区医学

Experimental Aging Research Pub Date : 2025-01-01 Epub Date: 2023-11-27 DOI: 10.1080/0361073X.2023.2286874

Songlan Liang, Xu Han, Shuang Diao, Hui Li

{"title":"COPD, Dietary Fiber Intake, and Cognitive Performance in Older Adults: A Cross-Sectional Study from NHANES 2011-2014.","authors":"Songlan Liang, Xu Han, Shuang Diao, Hui Li","doi":"10.1080/0361073X.2023.2286874","DOIUrl":"10.1080/0361073X.2023.2286874","url":null,"abstract":"Introduction: This study aimed to evaluate the modifying role of dietary fiber intake in the relationship between COPD and cognitive performance.Methods: Data of adults aged ≥60 years were extracted from the National Health and Nutrition Examination Survey (NHANES) 2011-2014. Participants with information on cognitive function measures were included. Dietary fiber intake, identified using participants' 24-h recall surveys, was grouped into high (>25 g/day) and low (≤25 g/day) levels. COPD was identified through self-reported physician diagnoses. Associations between dietary fiber intake, cognitive function and COPD were evaluated using the regression analysis.Results: Data of 2,189 participants were analyzed. Multivariate analysis revealed that COPD was significantly associated with lowered CERAD (adjusted beta [aBeta]: -0.17, 95% confidence interval [CI]: -0.33 to -0.002, p = .047) and DSST (aBeta: -2.23, 95% CI: -4.25 to -0.2, p = .032) scores in older adults. The analysis on the association between COPD and cognitive function stratified by dietary fiber intake revealed that COPD remained significantly associated with lowered CREAD among individuals with a high fiber intake (aBeta: -0.54, 95% CI: -1.00 to -0.08, p = .024).Conclusions: In US older adults, COPD is associated with reduced cognitive function. However, the findings do not support that high dietary fiber intake may modify the association between COPD and cognitive impairment.","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":" ","pages":"92-102"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138444418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Relationship Between Quality of Life and Depressive Symptoms Among Jordanian Community-Dwelling Older Adults. 约旦社区老年人生活质量与抑郁症状的关系

IF 1.4 4区医学

Experimental Aging Research Pub Date : 2025-01-01 Epub Date: 2023-11-22 DOI: 10.1080/0361073X.2023.2286873

Malakeh Z Malak, Anas H Khalifeh

{"title":"The Relationship Between Quality of Life and Depressive Symptoms Among Jordanian Community-Dwelling Older Adults.","authors":"Malakeh Z Malak, Anas H Khalifeh","doi":"10.1080/0361073X.2023.2286873","DOIUrl":"10.1080/0361073X.2023.2286873","url":null,"abstract":"Objective: The current study aimed to examine the relationship between depressive symptoms and quality of life among Jordanian community-dwelling older adults.Methods: A cross-sectional, descriptive correlational design was used. A convenience sample (N = 602) was selected to recruit the participants in the Amman governorate during the period from August to November 2021.Results: Findings demonstrated that the mean (SD) age of older adults was 67.5 (7.0) years and 51.5% of participants were females. Also, 54.1% of the participants experienced moderate to severe depressive symptoms with a total mean (SD) score was 8.57 on a scale of 0 to 15, while the mean (SD) for the quality of life scale was 12.12 (3.85) on a scale of 4 to 20. Significant differences existed in quality of life and depressive symptoms based on marital status (p < .001), educational level (p < .001), working status (p < .01), income (p < .001), and chronic disease (p < .01). Quality of life and its domains were negatively associated with depressive symptoms (B= - 0.596, p < .001). Also, marital status, working, educational level, income, and chronic disease were associated with depressive symptoms.Conclusion: Strategies to improve quality of life should be promoted to minimize depressive symptoms among older adults and consider significant demographic factors.","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":" ","pages":"19-34"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138290693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reactive Turning Behavior in Older Adults: Age-Related Decrease is Evident under Increased Task Demand. 老年人的反应性转向行为：在任务需求增加的情况下，与年龄有关的减少显而易见。

IF 1.4 4区医学

Experimental Aging Research Pub Date : 2024-12-13 DOI: 10.1080/0361073X.2024.2439743

Takahito Nakamura, Yuki Suda, Takahiro Higuchi

{"title":"Reactive Turning Behavior in Older Adults: Age-Related Decrease is Evident under Increased Task Demand.","authors":"Takahito Nakamura, Yuki Suda, Takahiro Higuchi","doi":"10.1080/0361073X.2024.2439743","DOIUrl":"https://doi.org/10.1080/0361073X.2024.2439743","url":null,"abstract":"A sudden turn initiated at an unpredictable moment is referred to as reactive turning. This study was designed to seek an age-related decrease in reactive turning when the task demand for turning was increased using a task-switching paradigm. Twenty healthy older adults and 14 younger adults were instructed to walk and execute a 90-degree turn under two conditions. In the \"reactive turning condition,\" participants were asked to turn abruptly when the initially presented travel direction (e.g. right) switched to the opposite direction (e.g. left) while walking. This switch occurred in only one-fifth of 40 trials. In the \"pre-planned turning condition,\" participants were informed of the direction beforehand. The onset of the center of mass (COM) shift in older participants failed to reach significance compared to younger participants. However, correlation analyses showed impaired turning performance in older participants, as those with delayed COM shift exhibited larger pelvic rotations over a short period during reactive turning. This suggests that, owing to increased task demand, older adults had difficulty quickly responding and sufficiently rotating their bodies in the new direction. We conclude that reactive turning with increased task demand, using a task-switching paradigm, is a key factor in detecting age-related performance decline.","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":" ","pages":"1-16"},"PeriodicalIF":1.4,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 修正。

IF 1.4 4区医学

Experimental Aging Research Pub Date : 2024-12-09 DOI: 10.1080/0361073X.2024.2436239

引用次数: 0

Therapeutic Effects Of Combined and Chronic Treatment of Tat-GluA23y and D-Serine on Cognitive Dysfunction in Postmenopausal Rats. Tat-GluA23y 和 D-丝氨酸联合慢性治疗对绝经后大鼠认知功能障碍的治疗作用

IF 1.4 4区医学

Experimental Aging Research Pub Date : 2024-10-01 Epub Date: 2023-09-03 DOI: 10.1080/0361073X.2023.2254660

Parvin Babaei, Shirin Javer, Mahmood Abedinzade

{"title":"Therapeutic Effects Of Combined and Chronic Treatment of Tat-GluA23y and D-Serine on Cognitive Dysfunction in Postmenopausal Rats.","authors":"Parvin Babaei, Shirin Javer, Mahmood Abedinzade","doi":"10.1080/0361073X.2023.2254660","DOIUrl":"10.1080/0361073X.2023.2254660","url":null,"abstract":"Background: The incidence of Alzheimer's disease (AD) in female gender compared with male has been addressed as a health concern, particularly in menopausal age. We here hypothesized that co-administration of NMDARs agonist (D-serine) and AMPARs endocytosis inhibitor (Tat-GluA23y) might be a potential target for alleviating memory impairment in sporadic Alzheimer model of rats.Methods: Forty-eight female Wistar rats weighing 200-220 randomly divided into six groups. One month later, ovariectomized rats underwent stereotaxic surgery and were cannulated into the brain lateral ventricles. Streptozotocin was injected (3 mg/kg), then animals received the related treatments until the day 51, which experienced acquisition of spatial memory in Morris Water Maze test. Finally, the level of phosphorylated cAMP response element binding protein (CREB) in the hippocampus was measured by Western blotting.Results: Co-administration of D-serine and GluA23y significantly enhanced the acquisition and retrieval of impaired spatial memory in ovariectomized rats with AD (p < .001). Compared to Glu-A 23, D-serine caused more improvement in the mentioned parameters above, however, these values for both groups were still significantly different from the control group (P < .05).Conclusion: Simultaneous treatment with D-serine and GluA23y synergistically improved STZ induced spatial memory impairment in OVX rat, probably partly via increase in phosphorylated CREB protein.","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":" ","pages":"633-651"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10143416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does the Sensory Experience of Words Boost Recollection in Aging? 词语的感官体验是否会促进老年人的回忆？

IF 1.4 4区医学

Experimental Aging Research Pub Date : 2024-10-01 Epub Date: 2023-11-10 DOI: 10.1080/0361073X.2023.2269800

Aurélia Bugaiska, Arnaud Witt, Patrick Bonin

{"title":"Does the Sensory Experience of Words Boost Recollection in Aging?","authors":"Aurélia Bugaiska, Arnaud Witt, Patrick Bonin","doi":"10.1080/0361073X.2023.2269800","DOIUrl":"10.1080/0361073X.2023.2269800","url":null,"abstract":"Objectives: We examine age-related differences in recollection and test the impact of words with high vs low sensory experience ratings (SER) in older and younger adults. We expected that the recollection of words with high SER would be similar in older and young adults, as they depend on knowledge, unlike recollection of words with a low SER, which would depend on executive functions.Methods: We manipulated the sensory experience of words (high vs. low) in encoding in young and older adults. The participants then took a word-recognition test using the Remember/Know paradigm (Gardiner, 1988). We also evaluated executive functions using several measures.Results: Results show that the age-related difference in recollective experience was eliminated under the high SER encoding condition. Moreover, Remember (R) responses in the low SER condition seem to be related to executive functioning, unlike R responses in the high SER condition and Know (K) responses in both low and high SER conditions.Discussion: Our study shows that the memory benefit of high-SER words is greater for older than younger adults. The study also supports the observation that older adults can compensate for their deficits by using sensory experience to consciously recollect information.","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":" ","pages":"705-717"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72013960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effects of Vitamin D on Movement and Cognitive Function in Senile Mice After Sevoflurane Anaesthesia. 维生素D对七氟醚麻醉后老年小鼠运动和认知功能的影响。

IF 1.4 4区医学

Experimental Aging Research Pub Date : 2024-10-01 Epub Date: 2023-11-22 DOI: 10.1080/0361073X.2023.2282350

Jialei Zhang, Xiaoling Zhang, Jun Zhao, Jie Wu

{"title":"The Effects of Vitamin D on Movement and Cognitive Function in Senile Mice After Sevoflurane Anaesthesia.","authors":"Jialei Zhang, Xiaoling Zhang, Jun Zhao, Jie Wu","doi":"10.1080/0361073X.2023.2282350","DOIUrl":"10.1080/0361073X.2023.2282350","url":null,"abstract":"Background: Vitamin D (VD) is a neuroactive steroid involved in many brain functions, such as neurotrophic, neuroimmune control and neurotransmission, which affects the growth and function of the brain. The purpose of this study is to explore the effect of VD on motor and cognitive function of aged mice after sevoflurane anesthesia.Method: We established sevoflurane anesthesia model and VD(-) and VD(+) mice model. The VD concentration of mice in each group was determined by enzyme-linked immunosorbent assay (ELISA). An open-field test was used to evaluate the mice's capacity for movement and exploration. A Y-maze test was used to gauge the mice's short-term memory. The primary purpose of the water-maze experiment was to examine mice's long-term spatial memory.Results: The ELISA results showed that the model was successfully constructed. In the open-field test, VD increased the exercise distance of mice (P < .05). In the Y-maze experiment, VD improved short-term memory impairment in mice (P < .05). In the water-maze test, VD increased the activity time and platform crossing number of mice in the target quadrant. (P < .05).Conclusion: Sevoflurane anesthesia caused cognitive dysfunction in aged mice, including reduced learning ability, memory loss, lower motor and exploratory abilities and depression, and VD deficiency aggravated these impairments. By supplementing with VD, learning ability and long-term memory were enhanced, motor and exploratory abilities were improved, and depression levels were reduced. Anxiety was also improved.","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":" ","pages":"817-831"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138290692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Autonomy and Physical Activity on Self-Rated Health of Older Adults in India: Gendered Analysis Using Structural Equation Models. 自主性和体力活动对印度老年人自评健康的影响:使用结构方程模型的性别分析

IF 1.4 4区医学

Experimental Aging Research Pub Date : 2024-10-01 Epub Date: 2023-11-12 DOI: 10.1080/0361073X.2023.2278982

Bevin Vijayan, Dipti Govil, Harihar Sahoo

{"title":"Effect of Autonomy and Physical Activity on Self-Rated Health of Older Adults in India: Gendered Analysis Using Structural Equation Models.","authors":"Bevin Vijayan, Dipti Govil, Harihar Sahoo","doi":"10.1080/0361073X.2023.2278982","DOIUrl":"10.1080/0361073X.2023.2278982","url":null,"abstract":"The gendered expectations and responsibilities placed upon women can impede their ability to participate in social activities and engage in physical leisure pursuits, ultimately having a negative impact on their health. Our study investigates the mechanisms through which gender influences individuals' engagement with physical activity during free time and how this relates to self-rated health outcomes among adults aged 45 years or older living in India. Using cross-sectional analysis and Structural Equation Modelling, we analyzed data stratified by gender and age from the Longitudinal Ageing Study of India to examine these conceptual pathways. We found that compared to men, women face greater limitations related to decision-making autonomy, experience more functional impairments, have weaker social networks that provide less support for engaging in leisure-time physical activity, leading them to report lower levels of overall wellbeing than men. Further analyses demonstrated distinct pathways through which each gender's level of social network connectivity shapes behavior - strong connections increase opportunities for women specifically to engage positively with both peers and physically active pursuits supporting overall wellness goals.","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":" ","pages":"767-784"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89717585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0