Experimental Aging Research最新文献

{"title":"Time-Varying Effect Models for Examining Age-Dynamic Associations in Gerontological Research.","authors":"Darcé M Costello, Terrence E Murphy","doi":"10.1080/0361073X.2022.2095606","DOIUrl":"10.1080/0361073X.2022.2095606","url":null,"abstract":"<p><strong>Objectives: </strong>Dynamic processes unfolding over later adulthood are of prime interest to gerontological researchers. Time-varying effect modeling (TVEM) accommodates dynamic change trajectories, but its use in gerontological research is limited. We introduce and demonstrate TVEM with an empirical example based on the National Health and Aging Trends Study (NHATS).</p><p><strong>Methods: </strong>We examined (a) age-varying prevalence of past month elevated symptoms of depression and anxiety and (b) age-varying associations between older adults' elevated symptoms of depression and anxiety and needing help with basic activities of daily living and educational attainment.</p><p><strong>Results: </strong>The proportion of participants reporting elevated symptoms of depression and anxiety in the past month increased gradually from 23-29% across the ages 70-92. Individuals needing help with ADLs had higher odds of reporting elevated symptoms of depression and anxiety, however the association was strongest for those in their 60s versus 80s. Across all ages, adults with lower education levels had higher odds of reporting elevated symptoms of depression and anxiety, an association that also varied by age.</p><p><strong>Conclusion: </strong>We demonstrated TVEM's value for studying dynamic associations that vary across chronological age. With the recent availability of free, user-friendly software for implementing TVEM, gerontological researchers have a new tool for exploring complex change processes that characterize older adults' development.</p>","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9249601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Observed Strategies on Naturalistic Associative Memory Tasks in Healthy Older Adults and Amnestic Mild Cognitive Impairment.","authors":"Kerryn E Pike,&nbsp;Bradley J Wright,&nbsp;Glynda J Kinsella","doi":"10.1080/0361073X.2022.2068327","DOIUrl":"https://doi.org/10.1080/0361073X.2022.2068327","url":null,"abstract":"<p><strong>Background: </strong>Understanding the strategies people with amnestic mild cognitive impairment (aMCI) spontaneously use can inform targeted memory training.</p><p><strong>Method: </strong>Strategy use was observed for 99 people with aMCI and 100 healthy older adults (HOA) on two memory tasks.</p><p><strong>Results: </strong>No differences were found between aMCI and HOA in the amount or types of strategies used, but strategy use varied with task. Association was more effective for one task, whereas on the other task, use of written notes or multiple strategies were detrimental to performance and related to poorer performance than active (spaced) retrieval, for aMCI.</p><p><strong>Conclusion: </strong>Our findings suggest the importance of identifying ineffective habits, in addition to instruction in more beneficial approaches.</p>","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9242244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amelioration of Cholesterol Rich diet-induced Impaired Cognition in AD Transgenic Mice by an LXR Agonist TO901317 Is Associated with the Activation of the LXR-β-RXR-α-ABCA1 Transmembrane Transport System and Improving the Composition of Lipid Raft.","authors":"Yang Na, Lin Ke, Zhang Jie, Wang Jinping, Meng Tao, Zhu Jie, Yang Liu, Zhou Yueqin","doi":"10.1080/0361073X.2022.2095605","DOIUrl":"10.1080/0361073X.2022.2095605","url":null,"abstract":"<p><strong>Background: </strong>It has been reported that LXR agonist can inhibit Aβ generation and alleviate Aβ-induced various adverse reactions in vivo and in vitro experiments, but the mechanisms have not been clarified. The study aimed to observe the effect of LXR agonist TO901317 on the cognitive function of AD transgenic mice fed with cholesterol-rich diet (CRD), and to explore the possible mechanism. Methods: 32 male 6-month-old double transgenic AD mice were enrolled and randomly divided into 4 groups: control (normal diet) group, CRD treatment group, TO901317 treatment group and GSK2033 treatment group. After 3 month, Morris water maze was for the changes of spatial exploration and memory ability; ELISA was for detecting the production of Aβ42 in the brain; the concentration of total cholesterol (TC), low density lipoprotein (LDL) and high density lipoprotein (HDL) in serum were detected by cholesterol enzyme colorimetry; Finally, the expression of LXR-β, RXR-α, ABCA1, caveolin-1, BACE1 and APP at protein level in the brains was measured by Western blotting.</p><p><strong>Results: </strong>Compared with the control group, the learning, memory ability and spatial exploration ability of the mice were more significantly serious in the CRD group (P<0.05); The contents of TC and LDL in the serum and the production of Aβ42 in the brains were significantly increased (P<0.05), but HDL was remarkably decreased (P<0.05); The protein levels of LXR-β, RXR-α and ABCA1 were also significantly decreased (P<0.05); The expression of caveolin-1, APP and BACE1 were evidently increased (P<0.05). However, after treatment with TO901317, the impaired learning and memory and spatial exploration ability of the mice were significantly improved (P<0.05); The contents of TC and LDL in serum and the production of Aβ42 in the brains were significantly decreased (P<0.05), but HLD was increased (P<0.05); The protein levels of LXR-β, RXR-α, ABCA1were all significantly increased (P<0.05), while, the expression of caveolin-1, APP and BACE1 were all significantly decreased (P<0.05). All the changes were reversed by GSK2033 (P<0.05).</p><p><strong>Conclusions: </strong>TO901317 attenuated the more serious impairment of spatial exploration, learning and memory in transgenic AD mice induced by CRD, and the mechanism may be that TO901317 could activate the LXR-β/RXR-α/ABCA1 transmembrane transport system, promote the cholesterol efflux, and decreased caveolin-1, APP and BACE1, further reduce Aβ42 in the brains.</p>","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9255178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No Common Factor Underlying Decline of Visual Abilities in Mild Cognitive Impairment.","authors":"Simona Garobbio,&nbsp;Karin S Pilz,&nbsp;Marina Kunchulia,&nbsp;Michael H Herzog","doi":"10.1080/0361073X.2022.2094660","DOIUrl":"https://doi.org/10.1080/0361073X.2022.2094660","url":null,"abstract":"<p><strong>Introduction: </strong>Recent work has shown an association between cognitive and visual impairments and two main theories were advanced, namely the sensory deprivation and the common cause theories. Most studies considered only basic visual functions such as visual acuity or visual field size and evaluated the association with dementia.</p><p><strong>Objectives: </strong>To reconcile between these theories and to test the link between visual and cognitive decline in mildly cognitive impaired people.</p><p><strong>Methods: </strong>We employed a battery of 19 visual tasks on 39 older adults with mild cognitive impairment and 91 without any evidence of cognitive decline, as measured by the Montreal Cognitive Assessment.</p><p><strong>Results: </strong>Our results show a strong association between visual impairment and mild cognitive impairment. In agreement with previous results with younger and healthy older adults, we found also only weak correlations between most tests in older adults with mild cognitive impairment.</p><p><strong>Conclusion: </strong>Our results suggest that visual and cognitive abilities decline simultaneously, but they do so independently across visual and cognitive functions and across participants.</p>","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9255174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Pain Intensity, Pain Belief, and Coping Strategies in Older Adults.","authors":"Şule Şimşek,&nbsp;Ayşe Nur Oymak Soysal,&nbsp;Atiye Kaş Özdemir","doi":"10.1080/0361073X.2022.2101304","DOIUrl":"https://doi.org/10.1080/0361073X.2022.2101304","url":null,"abstract":"<p><p>This study aimed to determine the relation between pain, pain belief, and coping strategies and the interaction effect of pain belief and coping stretegies on pain intensity in older adults living in Denizli. 601 older adults (68.32 ± 8.28 years) with good cognitive function participated in current study. Pain intensity, pain beliefs and coping strategies were assessed with Geriartric Pain Measure (GPM), Pain Beliefs Scale (PBS) and Pain Coping Inventory (PCI), respectively. Mean pain intensity of older adults was 53.6 ± 21 (0-99.96). There was a statistically significant difference in passive coping strategies between older adults with mild, moderate, and severe pain (p < .001). As organic pain belief and active coping strategies increase, the pain intensity decreases in older adults living in Denizli.</p>","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9618393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Same Goals, but Different Outcomes: Present-Focused versus Future-Focused Memory Beliefs Differentially Predict Young and Older Adults' Everyday Use of Memory Strategies.","authors":"Tara T Lineweaver,&nbsp;Abbey N Collins,&nbsp;Stephanie C Smith,&nbsp;Michelle Horhota,&nbsp;Jessica Crumley-Branyon","doi":"10.1080/0361073X.2022.2079926","DOIUrl":"https://doi.org/10.1080/0361073X.2022.2079926","url":null,"abstract":"ABSTRACT Objective We investigated whether beliefs about the current versus future effectiveness of memory strategies predict young and older adults’ everyday strategy use. Method 103 young and 91 older adults reported their memory goals, beliefs about the current and future effectiveness of various strategies, and frequency of use of each strategy type. Results The two age groups equally valued current and future memory. Young adults’ strategy selection related only to their beliefs about the strategies’ current effectiveness; older adults utilized approaches they perceived as effective for improving both future and current memory. Implications Findings highlight the importance of the temporal nature of memory strategy beliefs.","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9255173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specification for community management of osteoporosis","authors":"None Chinese Society of Gerontology and Geriatrics","doi":"10.26599/agr.2023.9340003","DOIUrl":"https://doi.org/10.26599/agr.2023.9340003","url":null,"abstract":"","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135673458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elderly disability prevention service specification","authors":"None Chinese Society of Gerontology and Geriatrics","doi":"10.26599/agr.2023.9340002","DOIUrl":"https://doi.org/10.26599/agr.2023.9340002","url":null,"abstract":"","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135673463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Technical guidelines for prevention and intervention of cognitive impairment in the elderly","authors":"None Chinese Society of Gerontology and Geriatrics","doi":"10.26599/agr.2023.9340004","DOIUrl":"https://doi.org/10.26599/agr.2023.9340004","url":null,"abstract":"","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135673464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guidelines for the construction of supporting environment for healthy aging","authors":"None Chinese Society of Gerontology and Geriatrics","doi":"10.26599/agr.2023.9340006","DOIUrl":"https://doi.org/10.26599/agr.2023.9340006","url":null,"abstract":"","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135673459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}