轻度认知障碍患者的工作记忆精确度和联想结合力。

IF 1.4 4区 医学 Q4 GERIATRICS & GERONTOLOGY
Experimental Aging Research Pub Date : 2024-03-01 Epub Date: 2023-02-08 DOI:10.1080/0361073X.2023.2172949
Yajun Jia, Steven Woltering, Nicolaas E P Deutz, Mariëlle P K J Engelen, Kimberly S Coyle, Maria R Maio, Masud Husain, Zhong-Xu Liu
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引用次数: 0

摘要

为了更好地了解轻度认知障碍(MCI)患者的工作记忆(WM)缺陷,我们采用项目定位延迟再现任务,对 21 名 MCI 患者和 16 名健康对照者的工作记忆信息精确度和联想结合进行了研究。在小睡 2 小时之前和之后,我们测量了 WM 以及其他执行功能(即追踪任务 (Trail Making Task, TMT) 和 Stroop 任务)。与健康参与者相比,患有 MCI 的参与者不仅在识别编码 WM 项目方面表现较差,而且在项目-位置联想结合和位置精确度方面也表现较差,即使只涉及一个项目也是如此。我们还发现 MCI 患者在 TMT 和 Stroop 任务上的变化,这反映出他们的注意力和抑制控制能力较差。我们的研究表明,联想结合和WM精确度可以可靠地将MCI患者与健康人区分开来。我们的研究表明,联想结合和 WM 精确度能可靠地将 MCI 患者与健康人区分开来。此外,大多数测量结果显示,抢救前后的组别没有不同的影响。这些发现可能有助于更好地理解MCI患者的认知缺陷,从而改进对MCI的诊断。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Working Memory Precision and Associative Binding in Mild Cognitive Impairment.

To better understand working memory (WM) deficits in Mild Cognitive Impairment (MCI), we examined information precision and associative binding in WM in 21 participants with MCI, compared to 16 healthy controls, using an item-location delayed reproduction task. WM, along with other executive functions (i.e. Trail Making Task (TMT) and Stroop task), were measured before and after a 2-h nap. The napping manipulation was intended as an exploratory element to this study exploring potential impacts of napping on executive functions.Compared to healthy participants, participants with MCI exhibited inferior performance not only in identifying encoded WM items but also on item-location associative binding and location precision even when only one item was involved. We also found changes on TMT and Stroop tasks in MCI, reflecting inferior attention and inhibitory control. Post-napping performance improved in most of these WM and other executive measures, both in MCI and their healthy peers.Our study shows that associative binding and WM precision can reliably differentiate MCIs from their healthy peers. Additionally, most measures showed no differential effect of group pre- and post-napping. These findings may contribute to better understanding cognitive deficits in MCI therefore improving the diagnosis of MCI.

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来源期刊
Experimental Aging Research
Experimental Aging Research 医学-老年医学
CiteScore
3.60
自引率
0.00%
发文量
68
审稿时长
>12 weeks
期刊介绍: Experimental Aging Research is a life span developmental and aging journal dealing with research on the aging process from a psychological and psychobiological perspective. It meets the need for a scholarly journal with refereed scientific papers dealing with age differences and age changes at any point in the adult life span. Areas of major focus include experimental psychology, neuropsychology, psychobiology, work research, ergonomics, and behavioral medicine. Original research, book reviews, monographs, and papers covering special topics are published.
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