Experimental Aging Research最新文献_第5页

IF 1.4 4区医学

Experimental Aging Research Pub Date : 2024-10-01 Epub Date: 2023-11-09 DOI: 10.1080/0361073X.2023.2278985

Kazuyuki Sato, Kazunobu Fukuhara, Takahiro Higuchi

{"title":"Age-Related Changes in the Utilization of Visual Information for Collision Prediction: A Study Using an Affordance-Based Model.","authors":"Kazuyuki Sato, Kazunobu Fukuhara, Takahiro Higuchi","doi":"10.1080/0361073X.2023.2278985","DOIUrl":"10.1080/0361073X.2023.2278985","url":null,"abstract":"The ability to predict collisions with moving objects deteriorates with aging. We followed the affordance-based model to identify optical variables that older adults had difficulty using for collision prediction. We reproduced a modified version of the interception task used in Steinmetz (Steinmetz, Layton, Powell, & Fajen, 2020, \"Affordance-based versus current - future accounts of choosing whether to pursue or abandon the chase of a moving target,\" Journal of Vision, 20(3), 8) in a virtual reality (VR) environment and newly introduced perturbation for each of three optical variables (vertical and horizontal expansions of a moving object and the bearing angle produced between participants and a moving object). We expected that perturbation would negatively affect the performance only for those who rely on the optical variable to perform the interception task effectively. We tested 18 older and 15 younger adults and showed that older participants were not negatively affected by the perturbation for the vertical and horizontal expansion of a moving object, while they showed decreased performance when the perturbation was introduced with a bearing angle. These findings suggest that predicting collisions with moving objects deteriorates with aging because the perception of object expansion is impaired with aging.","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":" ","pages":"800-816"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71520984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Diffusion Model Account of Cognitive Variability in Healthy Aging and Mild Cognitive Impairment. 健康老龄化和轻度认知障碍中认知变异性的扩散模型解释。

IF 1.4 4区医学

Experimental Aging Research Pub Date : 2024-09-29 DOI: 10.1080/0361073X.2024.2409588

Andrew J Aschenbrenner, Joshua J Jackson

引用次数: 0

Examination of the Relationship Between Sensory Processing Skills, Kinesiophobia and Fear of Falling in Older Adults with Hypertension and Normotension. 研究高血压和正常血压老年人的感觉处理能力、运动恐怖症和跌倒恐惧之间的关系。

IF 1.4 4区医学

Experimental Aging Research Pub Date : 2024-09-02 DOI: 10.1080/0361073X.2024.2397323

Mustafa Cemali, Mustafa Sarı, Demet Öztürk, Özgün Elmas, A Ayşe Karaduman

{"title":"Examination of the Relationship Between Sensory Processing Skills, Kinesiophobia and Fear of Falling in Older Adults with Hypertension and Normotension.","authors":"Mustafa Cemali, Mustafa Sarı, Demet Öztürk, Özgün Elmas, A Ayşe Karaduman","doi":"10.1080/0361073X.2024.2397323","DOIUrl":"https://doi.org/10.1080/0361073X.2024.2397323","url":null,"abstract":"Objectives: The aim of the study was to investigate fear of falling, kinesiophobia, and sensory processing in older adults with hypertension and normotension.Methods: Older adults, 62 with hypertension and 62 with normotension, aged 65-84 years were included in the study. The assessment of fear of falling was conducted using the Tinetti Falls Efficacy Scale, kinesiophobia was evaluated with the Tampa Kinesiophobia Scale, and sensory processing skills were analyzed with the Adolescent/Adult Sensory Profile.Results: Significant differences were found between the groups in terms of vestibular processing, visual processing and activity level, fear of falling and kinesiophobia (p < .05). No significant differences were found between the groups with respect to taste/smell, tactile, and auditory processing skills. The findings revealed that older adults with hypertension exhibited diminished vestibular and visual processing abilities, reduced activity levels, and heightened concerns about falling and a tendency to experience kinesiophobia. Fear of falling and kinesiophobia were found to increase with decreasing vestibular processing skills and activity levels in both groups (p < .05). Regression analysis revealed that age, kinesiophobia, vestibular processing, and activity levels were significant determinants of fear of falling (p < .05).Conclusion: It is recommended that older adults with hypertension be assessed in terms of sensory, functional, and mental health, with the objective of planning appropriate intervention approaches.","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AMPA Receptors Endocytosis Inhibition Attenuates Cognition Deficit Via c-Fos/BDNF Signaling in Amyloid β Neurotoxicity. 抑制AMPA受体的内吞作用可通过淀粉样β神经毒性中的c-Fos/BDNF信号转导减轻认知缺陷

IF 1.4 4区医学

Experimental Aging Research Pub Date : 2024-07-30 DOI: 10.1080/0361073X.2024.2377440

Kimia Eyvani, Negin Letafatkar, Parvin Babaei

{"title":"AMPA Receptors Endocytosis Inhibition Attenuates Cognition Deficit Via c-Fos/BDNF Signaling in Amyloid β Neurotoxicity.","authors":"Kimia Eyvani, Negin Letafatkar, Parvin Babaei","doi":"10.1080/0361073X.2024.2377440","DOIUrl":"https://doi.org/10.1080/0361073X.2024.2377440","url":null,"abstract":"Glutamatergic imbalance, particularly downregulation of α-amino-3-hydroxy-5-methyl-4- isoxazole propionic acid receptor (AMPARs) endocytosis, has been addressed as a possible reason for cognitive dysfunctions in Alzheimer's disease (AD). We hypothesized that inhibition of AMPAR endocytosis may ameliorate memory impairment in AD model of rats. To approach this, twenty-four adults male Wistar rats were divided into three groups: saline + saline (control group), Aβ + saline, and Aβ + Tat-GluR23Y (AMPA endocytosis inhibitor). Animals received an intracerebroventricular (i.c.v) injection of Aβ (1-42) to induce neuro-toxicity, followed by chronic administration of GluR23Y, and further behavioral assessments by MWM. Afterward, the hippocampal level of Brain Derived Neurotrophic Factor (BDNF) and c-Fos was measured via Western blotting. The results of our study revealed that chronic administration of GluR23Y improved both working and reference memories evidenced by shorter latency time and longer total time spent in the target zone in MWM. Additionally, this improvement was paralleled by an increase in BDNF, but a decrease in c-Fos. In conclusion, GluR23Y improves spatial memory impairment at least partly via elevating neuroprotective factor of BDNF and reducing apoptotic protein of c-Fos.","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.4,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Combined Effect of Tribulus terrestris Hydroalcoholic Extract and Swimming Exercise on Memory and Oxidative Stress in Old Male Rats. 刺蒺藜水醇提取物和游泳运动对老年雄性大鼠记忆力和氧化应激的联合影响

IF 1.4 4区医学

Experimental Aging Research Pub Date : 2024-07-29 DOI: 10.1080/0361073X.2024.2377432

Zinat Heydarnia Kalati, Hossein Harati, Seyed-Hosein Abtahi-Eivary, Mohammad Javad Dehestany Zarch, Younes Karami, Maryam Moghimian, Masoumeh Fani

{"title":"The Combined Effect of Tribulus terrestris Hydroalcoholic Extract and Swimming Exercise on Memory and Oxidative Stress in Old Male Rats.","authors":"Zinat Heydarnia Kalati, Hossein Harati, Seyed-Hosein Abtahi-Eivary, Mohammad Javad Dehestany Zarch, Younes Karami, Maryam Moghimian, Masoumeh Fani","doi":"10.1080/0361073X.2024.2377432","DOIUrl":"https://doi.org/10.1080/0361073X.2024.2377432","url":null,"abstract":"Background and objective: This study aims to assess the effect of swim exercise along with consumption of bindii hydroalcoholic extract on memory and the oxidative stress markers in old male rats.Materials and methods: This study was conducted on 32 old (400-500 g) and eight young male Wistar rats. The groups included young, old, old bindii (200 mg/kg), old exercise, and old bindii exercise (concurrent swimming training). All interventions were performed within 14 days. The animals' spatial memory was evaluated by the Y maze, radial maze, and shuttle box, Oxidative stress factors were also measured.Results: Compared to the old control group, the bindii extract along with swimming exercise significantly increased the periodic behavior percentage in the Y maze and the delay time in entry into the dark chamber in the shuttle box but no significant difference was seen in the reference memory error in the radial maze. Also, a significant increase in the amount of catalase (CAT) and antioxidant capacity (TAC) and a significant decrease in the amount of malondialdehyde (MDA) were observed in all treatment groups.Conclusion: These results show that exercise, along with the bindii extract consumption, can improve spatial and avoidance memory in old rats probably through the reduction of oxidative stress effects.","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":" ","pages":"1-15"},"PeriodicalIF":1.4,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mediating Role of Psychological Status in the Association Between Resiliency and Quality of Life Among Older Malaysians Living with Knee Osteoarthritis. 心理状态在患有膝关节骨关节炎的马来西亚老年人的复原力与生活质量之间的关联中的中介作用。

IF 1.4 4区医学

Experimental Aging Research Pub Date : 2024-07-18 DOI: 10.1080/0361073X.2024.2377436

Siti Sarah Norman, Sumaiyah Mat, Siti Salwana Kamsan, Sawal Hamid Md Ali, Nor Hamdan Mohamad Yahaya, Caryn Chan Mei Hsien, Dayang Balkis Md Ramli, Noorlaili Mohd Tohit, Norhayati Ibrahim, Suzana Shahar

{"title":"Mediating Role of Psychological Status in the Association Between Resiliency and Quality of Life Among Older Malaysians Living with Knee Osteoarthritis.","authors":"Siti Sarah Norman, Sumaiyah Mat, Siti Salwana Kamsan, Sawal Hamid Md Ali, Nor Hamdan Mohamad Yahaya, Caryn Chan Mei Hsien, Dayang Balkis Md Ramli, Noorlaili Mohd Tohit, Norhayati Ibrahim, Suzana Shahar","doi":"10.1080/0361073X.2024.2377436","DOIUrl":"https://doi.org/10.1080/0361073X.2024.2377436","url":null,"abstract":"Resilience increases the ability of an individual to overcome adversity. It has not yet been determined how resilience is linked to quality of life among individuals experiencing knee osteoarthritis symptoms. To explore the inter-relationships of psychological distress, resilience and quality of life among older individuals with knee osteoarthritis. The study examined older adults in Kuala Lumpur and Selangor, identifying osteoarthritis through verified physician diagnosis. Various factors, including resilience, psychological status, and quality of life, were measured. In the study with 338 older adults, 50.9% had knee osteoarthritis. Higher resilience was linked to lower depression, anxiety, and stress, and better quality of life in both groups with and without knee osteoarthritis. Psychological factors consistently mediated the link between resilience and quality of life even after controlling potential confounders. Analysis showed that depression, anxiety, and stress mediate the relationship between resilience and quality of life, indicating a significant influence even when considering various factors. Resilience appears to influence psychological well-being and quality of life among older adult with knee osteoarthritis.","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.4,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141633107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the Effect of Tai Chi Training on Depressive Symptoms in Perimenopausal Women on the Basis of Serum Kynurenine Metabolites. 基于血清犬尿氨酸代谢物研究太极拳训练对围绝经期妇女抑郁症状的影响

IF 1.4 4区医学

Experimental Aging Research Pub Date : 2024-07-18 DOI: 10.1080/0361073X.2024.2377427

Jing Liu, Jingmei Si, Weiwei Zhao

{"title":"Investigation of the Effect of Tai Chi Training on Depressive Symptoms in Perimenopausal Women on the Basis of Serum Kynurenine Metabolites.","authors":"Jing Liu, Jingmei Si, Weiwei Zhao","doi":"10.1080/0361073X.2024.2377427","DOIUrl":"https://doi.org/10.1080/0361073X.2024.2377427","url":null,"abstract":"Objective: To observe the effects of Tai Chi training on depression symptoms and serum kynurenine metabolites in perimenopausal women and explore the mechanism of Tai Chi training in anti-depression.Methods: A total of 72 perimenopausal women with depression were randomly selected from Lishi District and divided into a Tai Chi training group (36 cases) and a control group (36 cases). At the same time, 36 perimenopausal healthy women were randomly selected as the normal group. The Tai Chi training group was intervened with 24 simplified Tai Chi exercises, and the depression self-rating scale was used to evaluate the depression status. The levels of tryptophan (Trp) and kynurenine (KYN) metabolites in serum were determined by high-performance liquid chromatography-ultraviolet detection.Results: Before the experiment, compared with the normal healthy group, the depression self-rating scale scores, serum KYN and quinolinic acid (QUIN) levels, and KYN/Trp ratio of the control group and Tai Chi group were significantly increased (p < .01), and the serum kynurenic acid (KYNA) level was significantly decreased (p < .01). After the experiment, compared with the normal healthy group, the depression self-rating scale scores of the Tai Chi group were significantly decreased (p < .01), the serum KYNA content was increased (p < .01), the serum KYN and QUIN contents were significantly decreased (p < .01), and the KYN/Trp ratio was significantly decreased (p < .01).Conclusion: Tai Chi training can significantly improve depression symptoms in perimenopausal women. The mechanism of Tai Chi training in improving depression symptoms in perimenopausal women may be achieved by regulating abnormal kynurenine metabolism.","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":" ","pages":"1-19"},"PeriodicalIF":1.4,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141633106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Association Between Social Support and the Quality of Life of Older Adults in China: The Mediating Effect of Loneliness. 中国老年人的社会支持与生活质量之间的关系：孤独的中介效应

IF 1.4 4区医学

Experimental Aging Research Pub Date : 2024-07-16 DOI: 10.1080/0361073X.2024.2376966

Nannan Jiang, Hong Ye, Xinran Zhao, Yanli Zhang

{"title":"The Association Between Social Support and the Quality of Life of Older Adults in China: The Mediating Effect of Loneliness.","authors":"Nannan Jiang, Hong Ye, Xinran Zhao, Yanli Zhang","doi":"10.1080/0361073X.2024.2376966","DOIUrl":"https://doi.org/10.1080/0361073X.2024.2376966","url":null,"abstract":"Background: Quality of life, social support, and loneliness are common problems among older adults in China , but the relationships among these issues have not been clearly identified.Objectives: The present study aimed to determine the relationships among Quality of life, social support, and loneliness.Methods: A total of 560 older adults were randomly selected , the social support rating scale (SSRS), University of California at Los Angeles (UCLA) loneliness scale, and Short-Form 12 (SF-12) were employed to measure their degree of social support, level of loneliness, and quality of life.Results: The average physical component summary (PCS) score was 49.97±16.33, and the average mental component summary (MCS) score was 47.26±11.49. Loneliness plays a partial mediating role between social support and quality of life.Conclusion: Loneliness and a lack of social support will affect the quality of life of the older adults. Thus, we need to urgently strengthen the care and support for the older adults and alleviate the loneliness of the older adults in the community.","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":" ","pages":"1-15"},"PeriodicalIF":1.4,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Attentional Bias in Older Adults with Non-Clinical Depression: An Eye-Tracking Study. 非临床抑郁症老年人的注意偏差：眼动追踪研究

IF 1.4 4区医学

Experimental Aging Research Pub Date : 2024-07-14 DOI: 10.1080/0361073X.2024.2377430

Jing Yuan, Yina Chen, Xinyi Yuan, Yuchen Zhang, Yan Wang, Zejun Liu

{"title":"Attentional Bias in Older Adults with Non-Clinical Depression: An Eye-Tracking Study.","authors":"Jing Yuan, Yina Chen, Xinyi Yuan, Yuchen Zhang, Yan Wang, Zejun Liu","doi":"10.1080/0361073X.2024.2377430","DOIUrl":"https://doi.org/10.1080/0361073X.2024.2377430","url":null,"abstract":"Background: Cognitive models of depression assert that attentional biases play an important role in the maintenance of depression. However, few studies have explored attentional bias in depressed older adults, and no consistent conclusions have been reached.Methods: In the current study, we investigated attentional bias in older adults with non-clinical depression. Older adults aged over 60 with non-clinical depression and without depression were instructed to perform a free viewing task while their eye movements were tracked.Results: The results showed that, compared to older adults without depression, non-clinically depressed older adults had longer total fixation durations and a greater number of fixations on sad stimuli. Moreover, non-depressed older adults exhibited a preference for pleasant images, whereas this effect was not observed in older adults with non-clinical depression.Conclusion: This study suggested that non-clinically depressed older adults have attentional bias, which is manifested as increased attention to sad stimuli and decreased attention to pleasant stimuli.The current study has functional and potential functional implications.","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":" ","pages":"1-12"},"PeriodicalIF":1.4,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141616141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Cognitive Intervention and Rehabilitation Training on the Expression of miR-134-5p in Elderly Patients with Diabetes Mellitus and Cognitive Impairment. 认知干预和康复训练对糖尿病合并认知障碍老年患者 miR-134-5p 表达的影响

IF 1.4 4区医学

Experimental Aging Research Pub Date : 2024-07-14 DOI: 10.1080/0361073X.2024.2377431

Wenqiang Sun, Jihai Zhao, Weiwei Wang, Wei Zhang, Xiumei Feng, Jing Feng, Lisi Li

{"title":"Effects of Cognitive Intervention and Rehabilitation Training on the Expression of miR-134-5p in Elderly Patients with Diabetes Mellitus and Cognitive Impairment.","authors":"Wenqiang Sun, Jihai Zhao, Weiwei Wang, Wei Zhang, Xiumei Feng, Jing Feng, Lisi Li","doi":"10.1080/0361073X.2024.2377431","DOIUrl":"https://doi.org/10.1080/0361073X.2024.2377431","url":null,"abstract":"Objective: This study aimed to analyze the effect and potential mechanism of cognitive intervention and rehabilitation training in elderly patients with diabetes mellitus complicated with mild cognitive impairment.Methods: In this study, 128 elderly patients with diabetes mellitus complicated with mild cognitive impairment were randomly divided into the control group and the training group. The effects of the two groups were compared before and after the cognitive intervention. The expression of miR-134-5p was assessed by qRT-PCR. The relationships between miR-134-5p and Mini-Mental State Examination Scale and Montreal Cognitive Assessment Scale were evaluated.Results: After 3-month management, the Mini-Mental State Examination Scale, Montreal Cognitive Assessment Scale, the Chinese version of the diabetes self-efficacy rating scale, and WHO quality of life brief were improved in both control group and training group, and the training group showed better improvement. Cognitive intervention and rehabilitation training restricted the expression of miR-134-5p. The levels of miR-134-5p were pertinent to cognitive function.Conclusion: Cognitive intervention and rehabilitation training might prevent the development of diabetes mellitus complicated with mild cognitive impairment by inhibiting miR-134-5p.","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.4,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141616142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0