The Effects of Vitamin D on Movement and Cognitive Function in Senile Mice After Sevoflurane Anaesthesia.

IF 1.4 4区 医学 Q4 GERIATRICS & GERONTOLOGY
Experimental Aging Research Pub Date : 2024-10-01 Epub Date: 2023-11-22 DOI:10.1080/0361073X.2023.2282350
Jialei Zhang, Xiaoling Zhang, Jun Zhao, Jie Wu
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引用次数: 0

Abstract

Background: Vitamin D (VD) is a neuroactive steroid involved in many brain functions, such as neurotrophic, neuroimmune control and neurotransmission, which affects the growth and function of the brain. The purpose of this study is to explore the effect of VD on motor and cognitive function of aged mice after sevoflurane anesthesia.

Method: We established sevoflurane anesthesia model and VD(-) and VD(+) mice model. The VD concentration of mice in each group was determined by enzyme-linked immunosorbent assay (ELISA). An open-field test was used to evaluate the mice's capacity for movement and exploration. A Y-maze test was used to gauge the mice's short-term memory. The primary purpose of the water-maze experiment was to examine mice's long-term spatial memory.

Results: The ELISA results showed that the model was successfully constructed. In the open-field test, VD increased the exercise distance of mice (P < .05). In the Y-maze experiment, VD improved short-term memory impairment in mice (P < .05). In the water-maze test, VD increased the activity time and platform crossing number of mice in the target quadrant. (P < .05).

Conclusion: Sevoflurane anesthesia caused cognitive dysfunction in aged mice, including reduced learning ability, memory loss, lower motor and exploratory abilities and depression, and VD deficiency aggravated these impairments. By supplementing with VD, learning ability and long-term memory were enhanced, motor and exploratory abilities were improved, and depression levels were reduced. Anxiety was also improved.

维生素D对七氟醚麻醉后老年小鼠运动和认知功能的影响。
背景:维生素D (VD)是一种神经活性类固醇,参与许多脑功能,如神经营养、神经免疫控制和神经传递,影响大脑的生长和功能。本研究旨在探讨VD对七氟醚麻醉后老年小鼠运动和认知功能的影响。方法:建立七氟醚麻醉模型和VD(-)、VD(+)小鼠模型。采用酶联免疫吸附试验(ELISA)测定各组小鼠VD浓度。通过野外测试来评估小鼠的运动和探索能力。用y形迷宫测试来衡量老鼠的短期记忆。水迷宫实验的主要目的是考察小鼠的长期空间记忆。结果:ELISA结果显示模型构建成功。结论:七氟醚麻醉引起老年小鼠认知功能障碍,包括学习能力下降、记忆丧失、运动能力和探索能力下降以及抑郁,而VD缺乏加重了这些障碍。通过补充VD,学习能力和长期记忆得到增强,运动能力和探索能力得到改善,抑郁水平降低。焦虑也得到了改善。
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来源期刊
Experimental Aging Research
Experimental Aging Research 医学-老年医学
CiteScore
3.60
自引率
0.00%
发文量
68
审稿时长
>12 weeks
期刊介绍: Experimental Aging Research is a life span developmental and aging journal dealing with research on the aging process from a psychological and psychobiological perspective. It meets the need for a scholarly journal with refereed scientific papers dealing with age differences and age changes at any point in the adult life span. Areas of major focus include experimental psychology, neuropsychology, psychobiology, work research, ergonomics, and behavioral medicine. Original research, book reviews, monographs, and papers covering special topics are published.
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