An Investigation of Affective Personality Traits in Alzheimer's Disease: SEEKING as a Possible Predictor for Early-Stage Alzheimer's Dementia.

IF 1.4 4区医学 Q4 GERIATRICS & GERONTOLOGY

Experimental Aging Research Pub Date : 2024-10-01 Epub Date: 2023-09-11 DOI:10.1080/0361073X.2023.2256629

Ezgi Soncu Buyukiscan, Elif Yildirim, Asli Demirtas-Tatlidede, Basar Bilgic, Hakan Gurvit

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引用次数: 0

Abstract

Objective: The aim of the current study was to investigate affective personality traits in Alzheimer's disease, a neurodegenerative condition mainly characterized by episodic memory impairment.

Method: The sample included 69 participants from 3 diagnostic categories. Twenty-five participants were diagnosed with subjective cognitive impairment (SCI), 26 participants were diagnosed with mild cognitive impairment of the amnestic type (aMCI), and the remaining 18 participants were diagnosed with early-stage Alzheimer's dementia (ADD). Diagnostic labels were given as a result of detailed neurological, neuropsychological, and neuroradiological assessment. Affective personality traits were assessed via Affective Neuroscience Personality Scales (ANPS).

Results: The only significant intergroup difference was obtained for the SEEKING subscale of ANPS. Here, ADD group scored significantly lower compared to the SCI group. The results of logistic regression analysis also indicated that SEEKING score successfully predicted early-stage ADD diagnosis.

Conclusion: The results suggest that a specific personality constellation characterized by reduced investment in the outside world might be associated with Alzheimer's disease, either as a risk factor or a byproduct of the neurodegenerative process initiated by AD pathology.

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阿尔茨海默氏症患者的情感人格特质调查：SEEKING 作为早期阿尔茨海默氏症痴呆症的可能预测因子。

研究目的阿尔茨海默氏症是一种神经退行性疾病，主要表现为外显记忆障碍，本研究旨在调查阿尔茨海默氏症患者的情感人格特质：样本包括来自 3 个诊断类别的 69 名参与者。25名参与者被诊断为主观认知障碍（SCI），26名参与者被诊断为轻度失忆型认知障碍（aMCI），其余18名参与者被诊断为早期阿尔茨海默氏症痴呆（ADD）。诊断结果是通过详细的神经学、神经心理学和神经放射学评估得出的。情感人格特征通过情感神经科学人格量表（ANPS）进行评估：结果：ANPS的 "寻求 "分量表显示出了唯一明显的组间差异。与 SCI 组相比，ADD 组的得分明显较低。逻辑回归分析的结果也表明，SEEKING得分可成功预测早期ADD诊断：结果表明，以对外界投资减少为特征的特定人格组合可能与阿尔茨海默氏症有关，它可能是阿尔茨海默氏症病理引发的神经退行性过程的风险因素或副产品。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental Aging Research 医学-老年医学

CiteScore

3.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Experimental Aging Research is a life span developmental and aging journal dealing with research on the aging process from a psychological and psychobiological perspective. It meets the need for a scholarly journal with refereed scientific papers dealing with age differences and age changes at any point in the adult life span. Areas of major focus include experimental psychology, neuropsychology, psychobiology, work research, ergonomics, and behavioral medicine. Original research, book reviews, monographs, and papers covering special topics are published.