Experimental Aging Research最新文献

{"title":"Validity and Reliability of the Turkish Version of General Practitioner Assessment of Cognition.","authors":"Ebru Akbuğa Koç, Elif Tuğçe Çil, Şükriye Çakır, Aber Ahmetoğlu, Hager Yahya, Nilgün Çınar","doi":"10.1080/0361073X.2024.2435780","DOIUrl":"https://doi.org/10.1080/0361073X.2024.2435780","url":null,"abstract":"<p><p>The General Practitioner Assessment of Cognition (GPCOG) was explicitly developed as a brief cognitive screening tool for general practitioners. It consists of a patient section testing cognition and an informant section asking historical questions. This study aimed to test the validity and reliability of the Turkish version of GPCOG-Tr on older Turkish adults. The study included two hundred thirty (<i>n</i> = 230) community-dwelling individuals aged at least 55. The GPCOG was translated, back-translated, and revised to determine the final GPCOG-Tr. The sample was divided into the patient group (with memory complaints) and the control group (without memory complaints). The GPCOG-Tr was compared against standard criteria for diagnosis of dementia (Diagnostic and Statistical Manual of Mental Disorders - 5th edition), the Clinical Dementia Rating scale, the Mini-mental State Examination, The Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) subscale, and the Geriatric Depression Scale (GDS). The reliability test was done on 30 participants after two weeks. The two-stage method of administering the GPCOG-Tr had a sensitivity of 85%, a specificity of 92%, a misclassification rate of 11.3%, and a positive predictive value of 92%. The test-retest correlation coefficients ranged from 0.86 to 0.98. The GPCOG-Tr total was at least equivalent to the MMSE and ADAS-Cog in detecting dementia. The GPCOG-Tr displayed solid psychometric properties, offering the general practitioners an efficient cognitive instrument for older Turkish people.</p>","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.4,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142754922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Metabolic Disorders and Cognitive Domains in Community-Dwelling Older Adults.","authors":"Lys Gil Rodrigues Pedroso Anibal, Carolina Neves Freiria, Graziele Maria da Silva, Flávia Silva Arbex Borim, Tábatta Renata Pereira de Brito, Andréia de Oliveira Pain, Ivan Aprahamian, Marciane Milanski Ferreira, Ligiana Pires Corona","doi":"10.1080/0361073X.2024.2425236","DOIUrl":"https://doi.org/10.1080/0361073X.2024.2425236","url":null,"abstract":"<p><strong>Objectives: </strong>evaluate the association between Metabolic Syndrome (MetS) and cognitive performance (global and in each domain) in community-dwelling older adults.</p><p><strong>Methods: </strong>cross-sectional study with 544 participants (≥60 years). Cognition was assessed using the Cognitive Abilities Screening Instrument - Short (CASI-S), evaluating four domains: memory, orientation, executive function, recall. MetS was identified considering five components: abdominal obesity, diabetes, hypertriglyceridemia, low HDL, and hypertension. Mann-Whitney test and Poisson regression models adjusted for age and education were used to assess the differences in cognition scores.</p><p><strong>Results: </strong>Hypertensive participants had lower global cognition, and those with hypertriglyceridemia had lower memory scores; obese individuals reached lower executive function and higher recall scores. Diabetes was associated with worse recall in men, and low HDL to lower memory scores; hypertensive women had worse recall. In adjusted models, association between abdominal obesity, executive function and recall (total sample) remained significant (<i>p</i> = .003 and <i>p</i> = .048, respectively).</p><p><strong>Conclusions: </strong>Global cognition was not associated to metabolic disorders, but obesity was associated to lower executive function and higher recall.</p><p><strong>Clinical implications: </strong>Assessing each cognitive domain may be more sensitive in subjects with MetS components, and interaction between components, sex and education also must be considered to establish adequate care strategies for the older adults.</p>","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":" ","pages":"1-18"},"PeriodicalIF":1.4,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Cardiovascular Risk in Associations of Brain-Derived Neurotrophic Factor with Longitudinal Brain and Cognitive Trajectories in Older Adults.","authors":"Jennifer Shearon, Joshua Jackson, Denise Head","doi":"10.1080/0361073X.2024.2423593","DOIUrl":"10.1080/0361073X.2024.2423593","url":null,"abstract":"<p><strong>Background: </strong>Higher levels of brain-derived neurotrophic factor (BDNF) have been associated with better neurocognitive outcomes. BDNF is present in cardiovascular tissue, and some evidence suggests it may benefit cardiovascular function. The current study assessed whether there is a mediating and/or moderating role of cardiovascular health in the relationship between BDNF and brain and cognitive outcomes.</p><p><strong>Method: </strong>We examined longitudinal data from 397 older adults (aged 54-89;164 females, 233 males) enrolled in the Alzheimer's Disease Neuroimaging Initiative with available plasma BDNF, medical, neuroimaging, and cognitive assessments. We used path analysis and linear regression to estimate the mediating and moderating roles of two measures of cardiovascular health, the Framingham Risk Score (FRS) and pulse pressure, in the relationships between BDNF and longitudinal changes in brain structure (white matter hyperintensity volume, hippocampal volume, and primary visual cortex volume) and cognitive function (executive function, episodic memory, and language).</p><p><strong>Results: </strong>There was no significant association of plasma BDNF with FRS or pulse pressure (ps > 0.31), precluding mediation. There were no robust associations between BDNF and longitudinal change in any brain structural or cognitive measures (ps > .12). Higher FRS was significantly associated with greater increases in WMH volume (ps < .01). FRS and pulse pressure were not associated with any other brain structural or cognitive outcomes (ps > .07).</p><p><strong>Conclusion: </strong>These results suggest that cardiovascular health may not play an important role in the influence of BDNF on neurocognitive health in older adults.</p>","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":" ","pages":"1-21"},"PeriodicalIF":1.4,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Musculoskeletal Pain is Associated With Depressive Symptoms in Community-Dwelling Older Adults Independent of Physical Activity.","authors":"Eleonora Esposito, Italo Ribeiro Lemes, Paola Sinibaldi Salimei, Priscila Kalil Morelhão, Larissa Bragança Falcão Marques, Michael Douglas Silva Martins, Gobbi Cynthia, Marcia Rodrigues Franco, Rafael Zambelli Pinto","doi":"10.1080/0361073X.2024.2397322","DOIUrl":"10.1080/0361073X.2024.2397322","url":null,"abstract":"<p><strong>Background: </strong>Prevalence of chronic musculoskeletal pain and depressive symptoms in adults is high; however, whether there is an association between these conditions in older adults is unknown.</p><p><strong>Objective: </strong>The aim of this study was to investigate the association of depressive symptoms with chronic musculoskeletal pain, and specifically with chronic LBP and knee osteoarthritis (OA), in community-dwelling older adults. In addition, we explored whether physical activity can mitigate these associations.</p><p><strong>Methods: </strong>A cross-sectional study design. A cross-sectional study design. Participants recruited were older adults (age ≥60 years) living in the community. Chronic musculoskeletal pain was assessed by specific questions regarding the presence of chronic LBP and knee OA. Depressive symptoms were assessed with the Center for Epidemiologic Studies Depression Scale. Multivariable regression model adjusted for potential confounders (i.e., age, sex, economic status, body composition, and physical activity) was used to investigate the association between chronic musculoskeletal pain and depressive symptoms. Separate analyses were also conducted for older adults with LBP and with knee OA.</p><p><strong>Results: </strong>A total of 509 (69% women) older adults were recruited. The regression analysis showed that musculoskeletal pain was associated with higher depressive symptoms (<math><mi>β</mi></math> = 2.52, 95% CI: 0.50 to 4.54; p-value < .05) compared with older adults without chronic musculoskeletal pain. Similarly, in the fully adjusted model, which included physical activity, LBP was associated with higher depressive symptoms (<math><mi>β</mi></math> = 2.80, 95% CI: 0.82 to 4.79; p-value < .01). The association between knee OA and depressive symptoms was not statistically significant after adjusting for physical activity (<math><mi>β</mi></math> = 2.00, 95% CI: -0.13 to 4.13; p-value = .06).</p><p><strong>Conclusion: </strong>Older adults with chronic musculoskeletal pain have higher depressive symptoms scores, when compared to those without musculoskeletal pain. Physical activity does not seem to influence this association.</p>","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.4,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of the Disability in Activities of Daily Living in Nursing Home Residents: A Descriptive Study.","authors":"Ulku Kezban Sahin, Sevim Acaröz","doi":"10.1080/0361073X.2024.2421686","DOIUrl":"10.1080/0361073X.2024.2421686","url":null,"abstract":"<p><p><b>Background:</b> Disability in activities of daily living (ADL) is a common problem among nursing home residents. The purpose of this research was to evaluate the geriatric syndromes that contribute to disability in nursing home residents.<b>Method:</b> The cross-sectional study included 124 older adults from two nursing homes. ADL disability was assessed with the Barthel Index. The sociodemographic characteristics and geriatric syndromes, including malnutrition, sarcopenia risk, frailty, immobility, urinary incontinence, cognitive impairment, and balance dysfunction were evaluated.<b>Results:</b> The 124 residents had a mean age of 80.12 ± 9.20 years and included 55.67% males. Age, malnutrition, sarcopenia risk, frailty, immobility, urinary incontinence, cognitive impairment, and balance dysfunction were all significantly correlated with the Barthel Index. However, only malnutrition, immobility, and urinary incontinence were found to account for 84.9% of the variance in disability of nursing home residents in regression analysis. These geriatric syndromes are the best predictors of ADL disability in all models (<i>p</i> < .05).<b>Conclusion:</b> This study found that malnutrition, immobility, and urinary incontinence considerably contributed to the disability profile of nursing home residents. Health professionals need to develop multi-dimensional care and prevention strategies, especially for geriatric syndromes such as malnutrition, immobility, and urinary incontinence.</p>","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.4,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Age and Education on Discourse Cohesion.","authors":"Viktória Kevická, Jana Marková, Dana Buntová","doi":"10.1080/0361073X.2024.2409590","DOIUrl":"https://doi.org/10.1080/0361073X.2024.2409590","url":null,"abstract":"<p><strong>Background: </strong>Several studies have proven the presence of cohesion difficulties in neurogenic communication disorders. However, we still have very little information about discourse cohesion in the intact adult population and the factors that influence it. The aim of the present study is to provide additional information on this topic and to assess the effect of age and education on discourse cohesion.</p><p><strong>Methods: </strong>One hundred and eighty-two healthy Slovak-speaking adult participants were divided into three age groups and three education groups were asked to tell Cinderella's story. The cohesion of the obtained discourse samples was evaluated.</p><p><strong>Results: </strong>Our study indicates no significant effect of age. However, an increasing tendency of the occurrence of cohesive tie errors with increasing age was described. Education, on the other hand, turned out to be a statistically significant factor and had an impact on the overall use of cohesive ties as well as the use of referential pronouns.</p><p><strong>Conclusion: </strong>Our findings suggest that monitoring the influence of education when creating normative data for discourse cohesion is more important than monitoring the effect of age.</p>","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":" ","pages":"1-15"},"PeriodicalIF":1.4,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Spouses' Sensory Loss with Depressive Symptoms, Self-Reported Health, and Functional Disability Among Middle-Aged and Older Adults in China: A Cross-Sectional Study.","authors":"Xiaoyang Li, Weiping Huang, Hui Feng, Yinan Zhao, Jiahui Nan, Yunzhu Duan","doi":"10.1080/0361073X.2024.2418781","DOIUrl":"https://doi.org/10.1080/0361073X.2024.2418781","url":null,"abstract":"<p><strong>Objective: </strong>To investigate cross-sectional associations between spouses' sensory loss and depressive symptoms, self-rated health, and functional disability.</p><p><strong>Methods: </strong>We included 10,410 individuals from the China Health and Retirement Longitudinal Study. We used the cross-sectional design and determined hearing loss, vision loss, and dual sensory loss by self-reports. We assessed depressive symptoms using the Center for Epidemiological Studies Depression Scale. We assessed self-reported health status using one item. Functional disability was defined as having difficulties in activities of daily living (ADL) and instrumental activities of daily living (IADL).</p><p><strong>Results: </strong>Individuals with spouses' dual sensory loss had a higher prevalence of depressive symptoms (45.19%), ADL (17.31%), and IADL impairments (21.97%) and a lower rate of self-rated good health (20.78%) than those with no or single loss. Spouse's sensory loss was associated with depressive symptoms, self-rated health, ADL, and IADL impairments (<i>p</i> < .05). Husbands' ADL impairments were associated with wives' vision loss (<i>p</i> < .05). Wives' IADL impairments were associated with husbands' hearing loss (<i>p</i> < .05).</p><p><strong>Conclusions: </strong>Spouses' sensory loss was related to depressive symptoms, self-rated health, ADL, and IADL impairments. There was a gender specificity in the effect of spousal vision loss or hearing loss on ADL and IADL impairments.</p>","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":" ","pages":"1-19"},"PeriodicalIF":1.4,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Motor and Cognitive Dual-Task Demands on Ankle Dorsiflexor and Plantarflexor Force Control in Older Adults.","authors":"Riku Ishizaka, Ippei Nojima, Kazuto Ishida, Hideshi Sugiura, Aoki Takahashi, Kodai Minami, Tatsunori Watanabe","doi":"10.1080/0361073X.2024.2406172","DOIUrl":"https://doi.org/10.1080/0361073X.2024.2406172","url":null,"abstract":"<p><strong>Background: </strong>Force steadiness can be impaired under dual-task conditions in older adults. Since this impairment is attributed to their limited attentional resources, we hypothesized that the degree of cortical activity involved in muscle contraction would affect force steadiness under dual-task conditions. To test this hypothesis, based on the premise that dorsiflexion requires more cortical resources than plantarflexion, we compared the effects of additional motor and cognitive task demands on force steadiness between dorsiflexion and plantarflexion contractions in young and older adults.</p><p><strong>Method: </strong>Eighteen young and eighteen older adults performed a force tracking task by applying either isometric dorsiflexion or plantarflexion force concurrently with and without (control) secondary upper-limb motor or cognitive task.</p><p><strong>Results: </strong>Force steadiness was impaired by both secondary upper-limb motor and cognitive tasks for the dorsiflexors and plantarflexors in older adults. While force steadiness was impaired similarly by additional task demands regardless of the secondary task type for the dorsiflexors, the impairment effect was larger in the secondary cognitive than motor task for the plantarflexors.</p><p><strong>Conclusion: </strong>The effects of dual-task demand on force steadiness could depend on the degree of cortical activity involved in muscle contraction in older adults.</p>","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":" ","pages":"1-16"},"PeriodicalIF":1.4,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediating Effect of Cognitive Reserve in the Relationship Between Physical Activity and Cognitive Function in Community-Dwelling Older Adults.","authors":"Hao Ran Zhang, Jia Wei Wu, Lecong Wang, Ming Zhu Ye, Guo Hua Zheng","doi":"10.1080/0361073X.2024.2409587","DOIUrl":"10.1080/0361073X.2024.2409587","url":null,"abstract":"<p><p>The aim of this study was to investigate the mediating effect of cognitive reserve (CR) on the association between physical activity and cognitive function in community-dwelling older adults. A total of 495 community-dwelling older adults were included in this cross-sectional study. The CR, cognitive function, physical activity, and the potential confounders were assessed. Regression and bootstrap analyses were used to explore the mediating role of CR in physical activity and cognitive function. Compared to older adults with low to moderate physical activity, older adults with high physical activity had significantly better global cognitive function (βMoCA scores = 1.22, 95% CI 0.41 ~ 2.04) and visual spatial function (βCDT scores = 0.52, 95% CI 0.11 ~ 0.94) after adjustment for the confounders. CR mediated the association between physical activity and cognitive function with an indirect effect for global cognitive function (βMoCAscores = -0.29, 95% CI -0.56 ~ -0.09) and visual spatial function (βCDTscores = -0.14, 95% CI -0.28 ~ -0.05) after adjusting for the confounders, with 23.8% and 26.7% as percentage of mediation, respectively. These findings suggest that high physical activity could be effective in increasing cognitive reserve and preserving or improving cognitive function in community-dwelling older adults.</p>","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.4,"publicationDate":"2024-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Effects Of Combined and Chronic Treatment of Tat-GluA23y and D-Serine on Cognitive Dysfunction in Postmenopausal Rats.","authors":"Parvin Babaei, Shirin Javer, Mahmood Abedinzade","doi":"10.1080/0361073X.2023.2254660","DOIUrl":"10.1080/0361073X.2023.2254660","url":null,"abstract":"<p><strong>Background: </strong>The incidence of Alzheimer's disease (AD) in female gender compared with male has been addressed as a health concern, particularly in menopausal age. We here hypothesized that co-administration of NMDARs agonist (D-serine) and AMPARs endocytosis inhibitor (Tat-GluA23y) might be a potential target for alleviating memory impairment in sporadic Alzheimer model of rats.</p><p><strong>Methods: </strong>Forty-eight female Wistar rats weighing 200-220 randomly divided into six groups. One month later, ovariectomized rats underwent stereotaxic surgery and were cannulated into the brain lateral ventricles. Streptozotocin was injected (3 mg/kg), then animals received the related treatments until the day 51, which experienced acquisition of spatial memory in Morris Water Maze test. Finally, the level of phosphorylated cAMP response element binding protein (CREB) in the hippocampus was measured by Western blotting.</p><p><strong>Results: </strong>Co-administration of D-serine and GluA23y significantly enhanced the acquisition and retrieval of impaired spatial memory in ovariectomized rats with AD (<i>p</i> < .001). Compared to Glu-A 23, D-serine caused more improvement in the mentioned parameters above, however, these values for both groups were still significantly different from the control group (<i>P</i> < .05).</p><p><strong>Conclusion: </strong>Simultaneous treatment with D-serine and GluA23y synergistically improved STZ induced spatial memory impairment in OVX rat, probably partly via increase in phosphorylated CREB protein.</p>","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":" ","pages":"633-651"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10143416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}