Experimental Aging Research最新文献

{"title":"The Association Between Pain and Physical Frailty Among Older Adults in India: Depression and Insomnia as Mediators.","authors":"T Muhammad, Manacy Pai, Waad Ali","doi":"10.1080/0361073X.2024.2429314","DOIUrl":"10.1080/0361073X.2024.2429314","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the association between body pain and physical frailty among older adults in India and to examine whether this association is mediated by symptoms of depression and insomnia.</p><p><strong>Methods: </strong>Data were obtained from the Longitudinal Aging Study in India, comprising 31,464 adults aged 60 and older. Physical frailty was assessed using a modified version of the frailty phenotype developed by Fried and colleagues. Multivariable logistic regression was used to analyze associations, and the Karlson-Holm-Breen method was employed to evaluate mediation effects.</p><p><strong>Results: </strong>The prevalence of frailty was 30.65%, with women showing a higher prevalence than men (33.16% vs. 27.85%). Older adults experiencing body pain had increased odds of frailty (adjusted odds ratio [aOR]: 1.17, 95% CI: 1.06-1.35). Depression (aOR: 1.70, 95% CI: 1.44-2.01) and insomnia symptoms (aOR: 1.58, 95% CI: 1.38-1.81) were independently associated with higher odds of frailty. Mediation analysis showed that depression mediated 8.4% of the association between pain and frailty in men and 6.11% in women. Insomnia symptoms mediated 11.47% of the association in men and 14.54% in women.</p><p><strong>Conclusion: </strong>Body pain was significantly associated with a higher likelihood of frailty among older adults in India. Symptoms of depression and insomnia partially mediated this association, with a stronger mediating effect observed for insomnia in women. Inclusive health care strategies addressing pain, depression, and insomnia could help mitigate the risk of frailty in this population.</p>","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":" ","pages":"393-411"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Musculoskeletal Pain is Associated With Depressive Symptoms in Community-Dwelling Older Adults Independent of Physical Activity.","authors":"Eleonora Esposito, Italo Ribeiro Lemes, Paola Sinibaldi Salimei, Priscila Kalil Morelhão, Larissa Bragança Falcão Marques, Michael Douglas Silva Martins, Gobbi Cynthia, Marcia Rodrigues Franco, Rafael Zambelli Pinto","doi":"10.1080/0361073X.2024.2397322","DOIUrl":"10.1080/0361073X.2024.2397322","url":null,"abstract":"<p><strong>Background: </strong>Prevalence of chronic musculoskeletal pain and depressive symptoms in adults is high; however, whether there is an association between these conditions in older adults is unknown.</p><p><strong>Objective: </strong>The aim of this study was to investigate the association of depressive symptoms with chronic musculoskeletal pain, and specifically with chronic LBP and knee osteoarthritis (OA), in community-dwelling older adults. In addition, we explored whether physical activity can mitigate these associations.</p><p><strong>Methods: </strong>A cross-sectional study design. A cross-sectional study design. Participants recruited were older adults (age ≥60 years) living in the community. Chronic musculoskeletal pain was assessed by specific questions regarding the presence of chronic LBP and knee OA. Depressive symptoms were assessed with the Center for Epidemiologic Studies Depression Scale. Multivariable regression model adjusted for potential confounders (i.e., age, sex, economic status, body composition, and physical activity) was used to investigate the association between chronic musculoskeletal pain and depressive symptoms. Separate analyses were also conducted for older adults with LBP and with knee OA.</p><p><strong>Results: </strong>A total of 509 (69% women) older adults were recruited. The regression analysis showed that musculoskeletal pain was associated with higher depressive symptoms (<math><mi>β</mi></math> = 2.52, 95% CI: 0.50 to 4.54; p-value < .05) compared with older adults without chronic musculoskeletal pain. Similarly, in the fully adjusted model, which included physical activity, LBP was associated with higher depressive symptoms (<math><mi>β</mi></math> = 2.80, 95% CI: 0.82 to 4.79; p-value < .01). The association between knee OA and depressive symptoms was not statistically significant after adjusting for physical activity (<math><mi>β</mi></math> = 2.00, 95% CI: -0.13 to 4.13; p-value = .06).</p><p><strong>Conclusion: </strong>Older adults with chronic musculoskeletal pain have higher depressive symptoms scores, when compared to those without musculoskeletal pain. Physical activity does not seem to influence this association.</p>","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":" ","pages":"492-504"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling Cognitive Health Disparities: A Gender Perspective on Aging in India.","authors":"C V Irshad, Deepak Kumar Behera, Umakant Dash","doi":"10.1080/0361073X.2024.2448099","DOIUrl":"https://doi.org/10.1080/0361073X.2024.2448099","url":null,"abstract":"<p><strong>Objective: </strong>The study examined the association of various socioeconomic, demographic, health risk behavior, and social capital factors with the cognitive health status of older adults in India.</p><p><strong>Methods: </strong>Data from the Longitudinal Ageing Study in India (LASI, 2017-18), wave-1 was used. Binary logistic regression was applied to explore the significant predictor variables of poor cognitive health status. Further, decomposition analysis was employed to explore the gender differences in cognitive health status.</p><p><strong>Results: </strong>The results revealed that female older adults had a higher odds of poor cognitive health status than male older adults (aOR: 2.37; 99% CI: 1.97-2.85). Increasing years of age, not being in a marital union, lower levels of social capital, and the presence of health risk behavior increased the odds of poor cognitive health. Education had a protective effect against the decline in cognitive health. The decomposition analysis results indicated that the gender difference in educational attainment contributed largely to the gender inequality in poor cognitive health status.</p><p><strong>Conclusions: </strong>The results suggest that gender equality in educational attainment could reduce the gender difference in cognitive health among male and female older adults to a large extent.</p>","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":"51 4","pages":"552-567"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Metabolic Disorders and Cognitive Domains in Community-Dwelling Older Adults.","authors":"Lys Gil Rodrigues Pedroso Anibal, Carolina Neves Freiria, Graziele Maria da Silva, Flávia Silva Arbex Borim, Tábatta Renata Pereira de Brito, Andréia de Oliveira Pain, Ivan Aprahamian, Marciane Milanski Ferreira, Ligiana Pires Corona","doi":"10.1080/0361073X.2024.2425236","DOIUrl":"10.1080/0361073X.2024.2425236","url":null,"abstract":"<p><strong>Objectives: </strong>evaluate the association between Metabolic Syndrome (MetS) and cognitive performance (global and in each domain) in community-dwelling older adults.</p><p><strong>Methods: </strong>cross-sectional study with 544 participants (≥60 years). Cognition was assessed using the Cognitive Abilities Screening Instrument - Short (CASI-S), evaluating four domains: memory, orientation, executive function, recall. MetS was identified considering five components: abdominal obesity, diabetes, hypertriglyceridemia, low HDL, and hypertension. Mann-Whitney test and Poisson regression models adjusted for age and education were used to assess the differences in cognition scores.</p><p><strong>Results: </strong>Hypertensive participants had lower global cognition, and those with hypertriglyceridemia had lower memory scores; obese individuals reached lower executive function and higher recall scores. Diabetes was associated with worse recall in men, and low HDL to lower memory scores; hypertensive women had worse recall. In adjusted models, association between abdominal obesity, executive function and recall (total sample) remained significant (<i>p</i> = .003 and <i>p</i> = .048, respectively).</p><p><strong>Conclusions: </strong>Global cognition was not associated to metabolic disorders, but obesity was associated to lower executive function and higher recall.</p><p><strong>Clinical implications: </strong>Assessing each cognitive domain may be more sensitive in subjects with MetS components, and interaction between components, sex and education also must be considered to establish adequate care strategies for the older adults.</p>","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":" ","pages":"412-429"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Investigation of Non-Auditory Lexical Language Skills in Relation to Hearing Ability and Second Language Use in Older Adults.","authors":"Margreet Vogelzang","doi":"10.1080/0361073X.2024.2432238","DOIUrl":"10.1080/0361073X.2024.2432238","url":null,"abstract":"<p><p>This study explored how age-related hearing loss and second language use relate to non-auditory lexical language abilities in 74 older adults (mean age 63; range 50-73). Participants completed a cognitive task (backwards digit span) and two lexical tasks: a verbal fluency task, which has a stronger cognitive component, and a vocabulary task, which has a lesser cognitive component. Our findings suggest that fundamental language skills are distinct from perceptual difficulties - at least in a lexical task with a lesser cognitive component. In the lexical task with a stronger cognitive component, we found evidence for a complex relation between age-related hearing loss and the frequency of second language use.</p>","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":" ","pages":"430-443"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity and Reliability of the Turkish Version of General Practitioner Assessment of Cognition.","authors":"Ebru Akbuğa Koç, Elif Tuğçe Çil, Şükriye Çakır, Aber Ahmetoğlu, Hager Yahya, Nilgün Çınar","doi":"10.1080/0361073X.2024.2435780","DOIUrl":"10.1080/0361073X.2024.2435780","url":null,"abstract":"<p><p>The General Practitioner Assessment of Cognition (GPCOG) was explicitly developed as a brief cognitive screening tool for general practitioners. It consists of a patient section testing cognition and an informant section asking historical questions. This study aimed to test the validity and reliability of the Turkish version of GPCOG-Tr on older Turkish adults. The study included two hundred thirty (<i>n</i> = 230) community-dwelling individuals aged at least 55. The GPCOG was translated, back-translated, and revised to determine the final GPCOG-Tr. The sample was divided into the patient group (with memory complaints) and the control group (without memory complaints). The GPCOG-Tr was compared against standard criteria for diagnosis of dementia (Diagnostic and Statistical Manual of Mental Disorders - 5th edition), the Clinical Dementia Rating scale, the Mini-mental State Examination, The Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) subscale, and the Geriatric Depression Scale (GDS). The reliability test was done on 30 participants after two weeks. The two-stage method of administering the GPCOG-Tr had a sensitivity of 85%, a specificity of 92%, a misclassification rate of 11.3%, and a positive predictive value of 92%. The test-retest correlation coefficients ranged from 0.86 to 0.98. The GPCOG-Tr total was at least equivalent to the MMSE and ADAS-Cog in detecting dementia. The GPCOG-Tr displayed solid psychometric properties, offering the general practitioners an efficient cognitive instrument for older Turkish people.</p>","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":" ","pages":"444-457"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142754922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Spouses' Sensory Loss with Depressive Symptoms, Self-Reported Health, and Functional Disability Among Middle-Aged and Older Adults in China: A Cross-Sectional Study.","authors":"Xiaoyang Li, Weiping Huang, Hui Feng, Yinan Zhao, Jiahui Nan, Yunzhu Duan","doi":"10.1080/0361073X.2024.2418781","DOIUrl":"10.1080/0361073X.2024.2418781","url":null,"abstract":"<p><strong>Objective: </strong>To investigate cross-sectional associations between spouses' sensory loss and depressive symptoms, self-rated health, and functional disability.</p><p><strong>Methods: </strong>We included 10,410 individuals from the China Health and Retirement Longitudinal Study. We used the cross-sectional design and determined hearing loss, vision loss, and dual sensory loss by self-reports. We assessed depressive symptoms using the Center for Epidemiological Studies Depression Scale. We assessed self-reported health status using one item. Functional disability was defined as having difficulties in activities of daily living (ADL) and instrumental activities of daily living (IADL).</p><p><strong>Results: </strong>Individuals with spouses' dual sensory loss had a higher prevalence of depressive symptoms (45.19%), ADL (17.31%), and IADL impairments (21.97%) and a lower rate of self-rated good health (20.78%) than those with no or single loss. Spouse's sensory loss was associated with depressive symptoms, self-rated health, ADL, and IADL impairments (<i>p</i> < .05). Husbands' ADL impairments were associated with wives' vision loss (<i>p</i> < .05). Wives' IADL impairments were associated with husbands' hearing loss (<i>p</i> < .05).</p><p><strong>Conclusions: </strong>Spouses' sensory loss was related to depressive symptoms, self-rated health, ADL, and IADL impairments. There was a gender specificity in the effect of spousal vision loss or hearing loss on ADL and IADL impairments.</p>","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":" ","pages":"458-476"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of the Nocturnal Sleep on Learning of a Complex Motor Skill in Young and Older Adults.","authors":"Marina Gonçalves Leal, José Eduardo Dos Martírios Luz, Yara Lucy Fidelix, Eric Roig-Hierro, Giordano Marcio Gatinho Bonuzzi","doi":"10.1080/0361073X.2024.2439741","DOIUrl":"10.1080/0361073X.2024.2439741","url":null,"abstract":"<p><strong>Background/study context: </strong>Research on older adults has shown impairments in nocturnal sleep, impacting motor memory consolidation and learning. However, previous studies primarily focus on simple tasks, limiting generalization to complex motor activities. Moreover, no evidence exists on how sleep influences adaptability and relearning in older adults.</p><p><strong>Methods: </strong>Sixty older adults and 60 young adults practiced an underarm dart-throwing task. The participants were divided into 2 sub-groups: SLEEP, which practiced in the evening and was retested on the morning of the following day, and CONTROL, which practiced in the morning and was retested in the evening on the same day. The practice and retention phases were spaced 12 hours. We analyzed motor learning through persistence, adaptability and relearning rate.</p><p><strong>Results: </strong>Sleep did not enhance motor learning for any group. While young adults exhibited retention, older adults did not, especially after nocturnal sleep. There was no difference between sub-groups in adaptability. Older adults demonstrated inferior relearning compared to young adults, independently of sleep.</p><p><strong>Conclusion: </strong>Nocturnal sleep did not influence memory consolidation in any group. On the contrary, our findings suggest that nocturnal sleep harms retention in older adults. Age-related characteristics induce a worse relearning rate regardless of sleep occurrence.</p>","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":" ","pages":"538-551"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Cardiovascular Risk in Associations of Brain-Derived Neurotrophic Factor with Longitudinal Brain and Cognitive Trajectories in Older Adults.","authors":"Jennifer Shearon, Joshua Jackson, Denise Head","doi":"10.1080/0361073X.2024.2423593","DOIUrl":"10.1080/0361073X.2024.2423593","url":null,"abstract":"<p><strong>Background: </strong>Higher levels of brain-derived neurotrophic factor (BDNF) have been associated with better neurocognitive outcomes. BDNF is present in cardiovascular tissue, and some evidence suggests it may benefit cardiovascular function. The current study assessed whether there is a mediating and/or moderating role of cardiovascular health in the relationship between BDNF and brain and cognitive outcomes.</p><p><strong>Method: </strong>We examined longitudinal data from 397 older adults (aged 54-89;164 females, 233 males) enrolled in the Alzheimer's Disease Neuroimaging Initiative with available plasma BDNF, medical, neuroimaging, and cognitive assessments. We used path analysis and linear regression to estimate the mediating and moderating roles of two measures of cardiovascular health, the Framingham Risk Score (FRS) and pulse pressure, in the relationships between BDNF and longitudinal changes in brain structure (white matter hyperintensity volume, hippocampal volume, and primary visual cortex volume) and cognitive function (executive function, episodic memory, and language).</p><p><strong>Results: </strong>There was no significant association of plasma BDNF with FRS or pulse pressure (ps > 0.31), precluding mediation. There were no robust associations between BDNF and longitudinal change in any brain structural or cognitive measures (ps > .12). Higher FRS was significantly associated with greater increases in WMH volume (ps < .01). FRS and pulse pressure were not associated with any other brain structural or cognitive outcomes (ps > .07).</p><p><strong>Conclusion: </strong>These results suggest that cardiovascular health may not play an important role in the influence of BDNF on neurocognitive health in older adults.</p>","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":" ","pages":"505-525"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between Age, Chronic Pain, Cognitive Function, and Pain Sensitivity: A Comparison of Older and Younger Adults.","authors":"Fatma Kübra Çekok, Pınar Müge Altınkaya, Ayşenur Gökşen, Arda Aktaş, Turhan Kahraman","doi":"10.1080/0361073X.2025.2518041","DOIUrl":"https://doi.org/10.1080/0361073X.2025.2518041","url":null,"abstract":"<p><p>The aim of this study was to examine the associations between age, chronic pain, cognitive function, and pain sensitivity by comparing older and younger adults. The study included 30 older adults with chronic pain, 31 older adults without pain, 26 young adults with chronic pain, and 31 young adults without pain. Cognitive functions were assessed using the Mini-Mental State Examination, Stroop Test, and Clock Drawing Test. Pressure pain thresholds (PPT) were measured in the trapezius, deltoid, and tibialis anterior regions using an algometer. Significant differences were observed in most cognitive functions and PPTs between the groups, particularly between older adults with and without chronic pain, and young adults with and without chronic pain. Generally, moderate to strong negative correlations were found between pain sensitivity and cognitive performance in older adults with chronic pain. In contrast, young adults with chronic pain showed weaker and fewer correlations between pain sensitivity and cognitive function. Chronic pain has a more significant negative impact on cognitive function in older adults, who also exhibit stronger associations between pain sensitivity and cognitive decline. In contrast, younger adults with chronic pain demonstrate weaker correlations, potentially due to adaptive coping mechanisms. These findings highlight the need for age-specific interventions targeting both pain and cognitive decline in older populations.</p>","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":" ","pages":"1-15"},"PeriodicalIF":1.4,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}