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Involvement of CREB3L1 in erythropoiesis induced by JAK2 exon 12 mutation CREB3L1参与了JAK2第12外显子突变诱导的红细胞生成。
IF 2.5 4区 医学
Experimental hematology Pub Date : 2024-09-04 DOI: 10.1016/j.exphem.2024.104636
Maho Okuda , Marito Araki , Federico De Marchi , Soji Morishita , Misa Imai , Hanaka Fukada , Miki Ando , Norio Komatsu
{"title":"Involvement of CREB3L1 in erythropoiesis induced by JAK2 exon 12 mutation","authors":"Maho Okuda ,&nbsp;Marito Araki ,&nbsp;Federico De Marchi ,&nbsp;Soji Morishita ,&nbsp;Misa Imai ,&nbsp;Hanaka Fukada ,&nbsp;Miki Ando ,&nbsp;Norio Komatsu","doi":"10.1016/j.exphem.2024.104636","DOIUrl":"10.1016/j.exphem.2024.104636","url":null,"abstract":"<div><div><em>CREB3L1</em>, a gene encoding the endoplasmic reticulum stress transducer, is specifically overexpressed in platelet RNA from patients with myeloproliferative neoplasms (MPNs). However, the pathophysiological roles of <em>CREB3L1</em> overexpression remain unclear. In the present study, we aimed to study <em>CREB3L1</em> messenger RNA (mRNA) expression in the red blood cells (RBCs) of patients with MPN and its role in erythrocytosis. Elevated expression of <em>CREB3L1</em> was exclusively observed in the RBCs of patients with polycythemia vera (PV) harboring <em>JAK2</em> exon 12 mutations, but not in those harboring <em>JAK2</em> V617F mutation or control subjects. In erythropoiesis, <em>CREB3L1</em> expression was sharply induced in erythroblasts of bone marrow cells collected from patients with <em>JAK2</em> exon 12 mutation. This was also evident when erythropoiesis was induced in vitro using hematopoietic stem and progenitor cells (HSPCs) with <em>JAK2</em> exon 12 mutation. Interestingly, overexpression of <em>CREB3L1</em> in RBCs was observed in patients with reactive erythrocytosis whose serum erythropoietin (EPO) levels exceeded 100 mIU/mL. Elevated <em>CREB3L1</em> expression was also observed in the erythroblasts of a patient with acute erythroid leukemia. EPO-dependent induction of <em>CREB3L1</em> was evident in erythroblasts differentiated from HSPCs in vitro, regardless of driver mutation status or MPN pathogenesis. These data strongly suggest that <em>CREB3L1</em> overexpression in RBCs is associated with hyperactivation of the EPO receptor and its downstream molecule, JAK2. Short hairpin RNA (shRNA) knockdown of <em>CREB3L1</em> expression in HSPCs blocked erythroblast formation in vitro. These results suggest that <em>CREB3L1</em> is required for erythropoiesis in the presence of <em>JAK2</em> exon 12 mutation or high level of EPO, possibly by antagonizing cellular stress.</div></div>","PeriodicalId":12202,"journal":{"name":"Experimental hematology","volume":"139 ","pages":"Article 104636"},"PeriodicalIF":2.5,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IFC Editorial Board 国际金融公司编辑委员会
IF 2.5 4区 医学
Experimental hematology Pub Date : 2024-09-01 DOI: 10.1016/S0301-472X(24)00493-4
{"title":"IFC Editorial Board","authors":"","doi":"10.1016/S0301-472X(24)00493-4","DOIUrl":"10.1016/S0301-472X(24)00493-4","url":null,"abstract":"","PeriodicalId":12202,"journal":{"name":"Experimental hematology","volume":"137 ","pages":"Article 104628"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0301472X24004934/pdfft?md5=f60c3049f86fe120f913654750c64c4f&pid=1-s2.0-S0301472X24004934-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142147950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3216 – FORMATION OF PRE-LEUKEMIC STEM CELLS IN A KMT2A::AFF1 MURINE MODEL REQUIRES AN EMBRYONIC TARGET CELL 3216 - 在 kmt2a::aff1 小鼠模型中形成前白血病干细胞需要胚胎靶细胞
IF 2.6 4区 医学
Experimental hematology Pub Date : 2024-08-29 DOI: 10.1016/j.exphem.2024.104536
Charlotta Böiers, Ariana Calderón, Roshanak Ghazanfari, Shabnam Khazari, Stefan Lang, Mohamed Eldeeb, Sara Palo, Shamit Soneji, David Bryder, Charlotta Böiers
{"title":"3216 – FORMATION OF PRE-LEUKEMIC STEM CELLS IN A KMT2A::AFF1 MURINE MODEL REQUIRES AN EMBRYONIC TARGET CELL","authors":"Charlotta Böiers, Ariana Calderón, Roshanak Ghazanfari, Shabnam Khazari, Stefan Lang, Mohamed Eldeeb, Sara Palo, Shamit Soneji, David Bryder, Charlotta Böiers","doi":"10.1016/j.exphem.2024.104536","DOIUrl":"https://doi.org/10.1016/j.exphem.2024.104536","url":null,"abstract":"","PeriodicalId":12202,"journal":{"name":"Experimental hematology","volume":"10 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142197255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3203 – PROTEIN TYROSINE PHOSPHATASE PRL2 PROMOTES MLL-AF9 DRIVEN LEUKEMOGENESIS VIA INHIBITING THE P53 PATHWAY 3203 - 蛋白酪氨酸磷酸酶 prl2 通过抑制 p53 通路促进 mll-af9 驱动的白血病发生
IF 2.6 4区 医学
Experimental hematology Pub Date : 2024-08-29 DOI: 10.1016/j.exphem.2024.104523
Shiyu Xiao, Hongxia Chen, Michihiro Kobayashi, Sergio Barajas, Wenjie Cai, Yunpeng Bai, Zhong-Yin Zhang, Yan Liu
{"title":"3203 – PROTEIN TYROSINE PHOSPHATASE PRL2 PROMOTES MLL-AF9 DRIVEN LEUKEMOGENESIS VIA INHIBITING THE P53 PATHWAY","authors":"Shiyu Xiao, Hongxia Chen, Michihiro Kobayashi, Sergio Barajas, Wenjie Cai, Yunpeng Bai, Zhong-Yin Zhang, Yan Liu","doi":"10.1016/j.exphem.2024.104523","DOIUrl":"https://doi.org/10.1016/j.exphem.2024.104523","url":null,"abstract":"","PeriodicalId":12202,"journal":{"name":"Experimental hematology","volume":"27 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142197261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3194 – CLONAL HEMATOPOIESIS-ASSOCIATED DNMT3A MUTATIONS CAUSE INCREASED T CELL ACTIVATION AND DECREASED LEUKEMIC TUMOR BURDEN 3194 - 克隆造血相关的 dnmt3a 突变导致 t 细胞活化增加和白血病肿瘤负荷减少
IF 2.6 4区 医学
Experimental hematology Pub Date : 2024-08-29 DOI: 10.1016/j.exphem.2024.104514
LaShanale Wallace, Mark Engelken, Amina Metidji, Jacquelyn Myers, Heather Sheppard, Jeremy Crawford, John Harper, David Cullins, Paul Thomas, Esther Obeng
{"title":"3194 – CLONAL HEMATOPOIESIS-ASSOCIATED DNMT3A MUTATIONS CAUSE INCREASED T CELL ACTIVATION AND DECREASED LEUKEMIC TUMOR BURDEN","authors":"LaShanale Wallace, Mark Engelken, Amina Metidji, Jacquelyn Myers, Heather Sheppard, Jeremy Crawford, John Harper, David Cullins, Paul Thomas, Esther Obeng","doi":"10.1016/j.exphem.2024.104514","DOIUrl":"https://doi.org/10.1016/j.exphem.2024.104514","url":null,"abstract":"","PeriodicalId":12202,"journal":{"name":"Experimental hematology","volume":"28 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142197269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3207 – PLCL1 REGULATES HSC QUIESCENCE VIA INTRACELLULAR CA2+ ALTERATIONS 3207 - plcl1 通过细胞内 ca2+ 的变化调节 HSC 的静止状态
IF 2.6 4区 医学
Experimental hematology Pub Date : 2024-08-29 DOI: 10.1016/j.exphem.2024.104527
Tomohiro Yabushita, Yosuke Tanaka, Toshio Suda
{"title":"3207 – PLCL1 REGULATES HSC QUIESCENCE VIA INTRACELLULAR CA2+ ALTERATIONS","authors":"Tomohiro Yabushita, Yosuke Tanaka, Toshio Suda","doi":"10.1016/j.exphem.2024.104527","DOIUrl":"https://doi.org/10.1016/j.exphem.2024.104527","url":null,"abstract":"","PeriodicalId":12202,"journal":{"name":"Experimental hematology","volume":"11 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142197258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3202 – 6-O HEPARAN SULFATION REGULATES ACUTE MYELOID LEUKEMIA CHEMOTHERAPY RESISTANCE 3202 - 6-o 天冬酰胺硫酸化调节急性髓性白血病的化疗耐药性
IF 2.6 4区 医学
Experimental hematology Pub Date : 2024-08-29 DOI: 10.1016/j.exphem.2024.104522
Kelsey Woodruff, Nicollette Setiawan, Cyd McKay, Christina Root, Soheil Meshinchi, Christina Termini
{"title":"3202 – 6-O HEPARAN SULFATION REGULATES ACUTE MYELOID LEUKEMIA CHEMOTHERAPY RESISTANCE","authors":"Kelsey Woodruff, Nicollette Setiawan, Cyd McKay, Christina Root, Soheil Meshinchi, Christina Termini","doi":"10.1016/j.exphem.2024.104522","DOIUrl":"https://doi.org/10.1016/j.exphem.2024.104522","url":null,"abstract":"","PeriodicalId":12202,"journal":{"name":"Experimental hematology","volume":"68 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142197263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3198 – IGH TRANSLOCATIONS IN CHINESE PATIENTS WITH CHRONIC LYMPHOCYTICLEUKEMIA: CLINICOPATHOLOGIC CHARACTERISTICS AND GENETIC PROFILE 3198 - 中国慢性淋巴细胞白血病患者的高易位：临床病理特征和遗传特征
IF 2.6 4区 医学
Experimental hematology Pub Date : 2024-08-29 DOI: 10.1016/j.exphem.2024.104518
Ying Wang, Qinlu Li, Shugang Xing, Heng Zhang
{"title":"3198 – IGH TRANSLOCATIONS IN CHINESE PATIENTS WITH CHRONIC LYMPHOCYTICLEUKEMIA: CLINICOPATHOLOGIC CHARACTERISTICS AND GENETIC PROFILE","authors":"Ying Wang, Qinlu Li, Shugang Xing, Heng Zhang","doi":"10.1016/j.exphem.2024.104518","DOIUrl":"https://doi.org/10.1016/j.exphem.2024.104518","url":null,"abstract":"","PeriodicalId":12202,"journal":{"name":"Experimental hematology","volume":"7 46 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142197267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3197 – NMEMK COLONY-FORMING CELLS IN HUMAN UMBILICAL CORD BLOOD 3197 - 人类脐带血中的 nmemk 群体形成细胞
IF 2.6 4区 医学
Experimental hematology Pub Date : 2024-08-29 DOI: 10.1016/j.exphem.2024.104517
Lisha Wang, Qingyun Zhang, Fang Dong, Hideo Ema
{"title":"3197 – NMEMK COLONY-FORMING CELLS IN HUMAN UMBILICAL CORD BLOOD","authors":"Lisha Wang, Qingyun Zhang, Fang Dong, Hideo Ema","doi":"10.1016/j.exphem.2024.104517","DOIUrl":"https://doi.org/10.1016/j.exphem.2024.104517","url":null,"abstract":"","PeriodicalId":12202,"journal":{"name":"Experimental hematology","volume":"79 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142197271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3219 – VASCULAR ENDOTHELIAL GROWTH FACTOR-INDUCED VASCULAR PERMEABILITY RESULTS IN DRASTIC AND REVERSIBLE HEMATOPOIETIC STEM CELL MOBILIZATION 3219 - 血管内皮生长因子诱导的血管通透性导致造血干细胞的急剧和可逆动员
IF 2.6 4区 医学
Experimental hematology Pub Date : 2024-08-29 DOI: 10.1016/j.exphem.2024.104539
Stephanie Smith-Berdan, Mark Landon, Bryan Petkus, Leah Kramer, Alyssa Bercassio, Tobin Berger-Cahn, E Forsberg
{"title":"3219 – VASCULAR ENDOTHELIAL GROWTH FACTOR-INDUCED VASCULAR PERMEABILITY RESULTS IN DRASTIC AND REVERSIBLE HEMATOPOIETIC STEM CELL MOBILIZATION","authors":"Stephanie Smith-Berdan, Mark Landon, Bryan Petkus, Leah Kramer, Alyssa Bercassio, Tobin Berger-Cahn, E Forsberg","doi":"10.1016/j.exphem.2024.104539","DOIUrl":"https://doi.org/10.1016/j.exphem.2024.104539","url":null,"abstract":"","PeriodicalId":12202,"journal":{"name":"Experimental hematology","volume":"79 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142197249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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