Nucleic acid metabolism: the key therapeutic target for myeloid tumors

IF 2.5 4区 医学 Q2 HEMATOLOGY
Tomohiro Yabushita , Susumu Goyama
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引用次数: 0

Abstract

Nucleic acid analogs, including cytarabine, decitabine, and azacitidine, have significantly advanced therapeutic approaches for myeloid tumors over the past five decades. Nucleic acid metabolism is a crucial pathway driving myeloid tumorigenesis, with emerging evidence indicating that myeloid tumors are particularly dependent on the de novo nucleotide synthesis pathway, underscoring its potential as a therapeutic target. This review provides a comprehensive overview of nucleic acid metabolism, focusing on de novo nucleotide synthesis. We then described the range of clinically utilized agents targeting nucleic acid metabolism and discussed our recent findings on the nonepigenetic actions of decitabine, as well as the therapeutic effects of inosine monophosphate dehydrogenase (IMPDH) inhibitors in the treatment of myeloid tumors.
核酸代谢:髓系肿瘤的关键治疗靶点。
核酸类似物,包括阿糖胞苷、地西他滨和阿扎胞苷,在过去的50年里显著地促进了髓系肿瘤的治疗方法。核酸代谢是驱动髓系肿瘤发生的关键途径,新出现的证据表明髓系肿瘤特别依赖于从头核苷酸合成途径,强调了其作为治疗靶点的潜力。这篇综述提供了一个全面的概述核酸代谢,特别侧重于从头核苷酸合成。然后,我们描述了临床使用的靶向核酸代谢的药物范围,并讨论了我们最近在地西他滨的非表观遗传作用方面的发现,以及IMPDH抑制剂在髓系肿瘤治疗中的治疗效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Experimental hematology
Experimental hematology 医学-血液学
CiteScore
5.30
自引率
0.00%
发文量
84
审稿时长
58 days
期刊介绍: Experimental Hematology publishes new findings, methodologies, reviews and perspectives in all areas of hematology and immune cell formation on a monthly basis that may include Special Issues on particular topics of current interest. The overall goal is to report new insights into how normal blood cells are produced, how their production is normally regulated, mechanisms that contribute to hematological diseases and new approaches to their treatment. Specific topics may include relevant developmental and aging processes, stem cell biology, analyses of intrinsic and extrinsic regulatory mechanisms, in vitro behavior of primary cells, clonal tracking, molecular and omics analyses, metabolism, epigenetics, bioengineering approaches, studies in model organisms, novel clinical observations, transplantation biology and new therapeutic avenues.
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