Experimental hematology最新文献_第7页

3212 – MEGAKARYOCYTES SENSE INFECTION AND PRIME ADJACENT HEMATOPOIETIC STEM CELLS FOR INFLAMMATION 3212 - 巨核细胞能感知感染，并为邻近的造血干细胞提供炎症处理素材

IF 2.6 4区医学

Experimental hematology Pub Date : 2024-08-29 DOI: 10.1016/j.exphem.2024.104532

Yang Zhang, Timm Schroeder

引用次数: 0

3200 – DEVELOPMENTAL REGULATION OF ENDOTHELIAL-TO-HEMATOPOIETIC TRANSITION FROM INDUCED PLURIPOTENT STEM CELLS 3200 - 诱导多能干细胞从内皮细胞向造血细胞转化的发育调控

IF 2.6 4区医学

Experimental hematology Pub Date : 2024-08-29 DOI: 10.1016/j.exphem.2024.104520

Rachel Wellington, Xiaoyi Cheng, Clyde Campbell, Cole Trapnell, Raquel Espin-Palazon, Brandon Hadland, Sergei Doulatov

引用次数: 0

3215 – TWO NOVEL ENHANCERS OF CDKN1A ARE EPIGENETICALLY REGULATED BY THE CHROMATIN ASSEMBLY FACTOR 1 AND CEBPA IN ACUTE MYELOID LEUKEMIA 3215 - 急性髓性白血病中 CDKN1A 的两个新型增强子受染色质组装因子 1 和 cebpa 的表观遗传调控

IF 2.6 4区医学

Experimental hematology Pub Date : 2024-08-29 DOI: 10.1016/j.exphem.2024.104535

Xiaoqin Zhu, Sean Walulik, Sarai Dean, Andrew Volk

引用次数: 0

3213 – SINGLE-CELL COMPUTER VISION UNVEILS LATENT MORPHOLOGICAL CHANGES CAUSED BY MYELOID NEOPLASM MUTATIONS 3213 - 单细胞计算机视觉揭示骨髓肿瘤突变引起的潜伏形态变化

IF 2.6 4区医学

Experimental hematology Pub Date : 2024-08-29 DOI: 10.1016/j.exphem.2024.104533

Helong Gary Zhao, Sarmad Khan, Dominik Faerber, Michael Deininger, Florian Buettner

引用次数: 0

3204 – CD83 MARKS ACUTE INFLAMMATORY STRESS ACTIVATION IN HUMAN HEMATOPOIETIC STEM CELLS AND ITS DEPLETION RESTRAINS INFLAMMATION RESPONSE 3204 - cd83 标志着人类造血干细胞的急性炎症应激激活，消耗它可抑制炎症反应

IF 2.6 4区医学

Experimental hematology Pub Date : 2024-08-29 DOI: 10.1016/j.exphem.2024.104524

Stephanie Xie, Murtaza Nagree, Andy Zeng, Angelica Varesi, Sayyam Shah, MIchael Zhang, Isabel Lim, Hyerin Kim, Liqing Jin, Mason Boulanger, John Dick

引用次数: 0

3192 – ADAR1P150 PROTEIN, INDEPENDENT OF ITS A-TO-I RNA EDITING ACTIVITY, REGULATES PERIPHERAL T CELL HOMEOSTASIS AND HSC REPOPULATING CAPACITY 3192 - adar1p150 蛋白与其 a-to-i rna 编辑活性无关，可调节外周 t 细胞的稳态和 hsc 再填充能力

IF 2.6 4区医学

Experimental hematology Pub Date : 2024-08-29 DOI: 10.1016/j.exphem.2024.104512

Carl Walkley, Jacki Heraud-Farlow, Maddison Stewart, Monique Smeets, David Izon, Scott Taylor, Zhen Liang, Alistair Chalk, Ankita Goradia, Shi-Bin Hu, Jin Billy Li, Louise Purton

引用次数: 0

A-to-I RNA editing and hematopoiesis A 到 I RNA 编辑与造血。

IF 2.5 4区医学

Experimental hematology Pub Date : 2024-08-24 DOI: 10.1016/j.exphem.2024.104621

Zhen Liang , Carl R. Walkley , Jacki E. Heraud-Farlow

引用次数: 0

SI: new culture methods in experimental hematology SI：实验血液学的新培养方法。

IF 2.5 4区医学

Experimental hematology Pub Date : 2024-08-19 DOI: 10.1016/j.exphem.2024.104617

Kristina Kirschner

引用次数: 0

Biomarkers for aging of blood – how transferable are they between mice and humans? 血液老化的生物标志物--它们在小鼠和人类之间的可转移性如何？

IF 2.5 4区医学

Experimental hematology Pub Date : 2024-08-10 DOI: 10.1016/j.exphem.2024.104600

Vithurithra Tharmapalan , Wolfgang Wagner

{"title":"Biomarkers for aging of blood – how transferable are they between mice and humans?","authors":"Vithurithra Tharmapalan , Wolfgang Wagner","doi":"10.1016/j.exphem.2024.104600","DOIUrl":"10.1016/j.exphem.2024.104600","url":null,"abstract":"<div><div>Aging significantly impacts the hematopoietic system, reducing its regenerative capacity and ability to restore homeostasis after stress. Mouse models have been invaluable in studying this process due to their shorter lifespan and the ability to explore genetic, treatment, and environmental influences on aging. However, not all aspects of aging are mirrored between species. This review compares three key aging biomarkers in the hematopoietic systems of mice and humans: myeloid bias, telomere attrition, and epigenetic clocks. Myeloid bias, marked by an increased fraction of myeloid cells and decreased lymphoid cells, is a significant aging marker in mice but is scarcely observed in humans after childhood. Conversely, telomere length is a robust aging biomarker in humans, whereas mice exhibit significantly different telomere dynamics, making telomere length less reliable in the murine system. Epigenetic clocks, based on DNA methylation changes at specific genomic regions, provide precise estimates of chronologic age in both mice and humans. Notably, age-associated regions in mice and humans occur at homologous genomic locations. Epigenetic clocks, depending on the epigenetic signatures used, also capture aspects of biological aging, offering powerful tools to assess genetic and environmental impacts on aging. Taken together, not all blood aging biomarkers are transferable between mice and humans. When using murine models to extrapolate human aging, it may be advantageous to focus on aging phenomena observed in both species. In conclusion, although mouse models offer significant insights, selecting appropriate biomarkers is crucial for translating findings to human aging.</div></div>","PeriodicalId":12202,"journal":{"name":"Experimental hematology","volume":"140 ","pages":"Article 104600"},"PeriodicalIF":2.5,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimization of pre-enrichment strategies for mouse hematopoietic stem cell isolation and metabolomic analysis 优化小鼠造血干细胞分离和代谢组学分析的预富集策略。

IF 2.5 4区医学

Experimental hematology Pub Date : 2024-08-02 DOI: 10.1016/j.exphem.2024.104588

Célina Nielsen , Youzhong Liu , Fleur Leguay , Hernán A. Tirado , Nicolas Dauguet , Nick van Gastel

{"title":"Optimization of pre-enrichment strategies for mouse hematopoietic stem cell isolation and metabolomic analysis","authors":"Célina Nielsen , Youzhong Liu , Fleur Leguay , Hernán A. Tirado , Nicolas Dauguet , Nick van Gastel","doi":"10.1016/j.exphem.2024.104588","DOIUrl":"10.1016/j.exphem.2024.104588","url":null,"abstract":"<div><p>Blood cell production arises from the activity of hematopoietic stem cells (HSCs), defined by their self-renewal capacity and ability to give rise to all mature blood cell types. The mouse remains one of the most studied species in hematological research, and markers to define and isolate mouse HSCs are well-established. Given the very low frequency of HSCs in the bone marrow, stem cell pre-enrichment by red blood cell lysis and magnetic cell separation is often performed as part of the isolation process to reduce sorting times. Several pre-enrichment strategies are available, differing in their speed, degree of enrichment, final cell yield, and cost. In the current study, we performed a side-by-side comparison and provide a decision tree to help researchers select a pre-enrichment strategy for mouse HSC isolation depending on their downstream application. We then compared different pre-enrichment techniques in combination with metabolomics analysis of HSCs, where speed, yield and temperature during pre-enrichment are crucial factors, and found that the choice of pre-enrichment strategy significantly impacts the number of metabolites detected and levels of individual metabolites in HSCs.</p></div>","PeriodicalId":12202,"journal":{"name":"Experimental hematology","volume":"139 ","pages":"Article 104588"},"PeriodicalIF":2.5,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0301472X24004478/pdfft?md5=ff6edb64a7b6884a702ea1d4edb428e5&pid=1-s2.0-S0301472X24004478-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0