Experimental hematology最新文献

{"title":"FAM210B Regulates Iron Homeostasis and Sex-Specific Responses in Stress Erythropoiesis.","authors":"Mark Perfetto, Muhammad Ishfaq, Aiden Mohideen, Catherine M Rondelli, Samantha Gillis, Jesus Tejero, Amber N Stratman, Rebecca Riggins, Yvette Y Yien","doi":"10.1016/j.exphem.2025.104797","DOIUrl":"https://doi.org/10.1016/j.exphem.2025.104797","url":null,"abstract":"<p><p>Iron is required for redox homeostasis but poses toxicity risks due to its redox activity. Erythropoiesis hence requires tight regulation of iron utilization for hemoglobin synthesis. The requirement for iron in erythropoiesis has necessitated the evolution of mechanisms to handle the iron required for hemoglobinization. FAM210B was identified as a regulator of mitochondrial iron import and heme synthesis in erythroid cell culture and zebrafish models. Here, we demonstrate that while FAM210B is required for erythroid differentiation and heme synthesis under standard cell culture conditions, holotransferrin supplementation was sufficient to chemically complement the iron-deficient phenotype. To investigate the role of FAM210B in erythropoiesis, we used knockout mice. While Fam210b^-/- mice were viable and did not exhibit overt erythropoietic defects in the bone marrow, the male mice exhibited an increase in serum transferrin suggesting sex-specific alterations in systemic iron sensing. Upon phlebotomy-induced stress erythropoiesis, Fam210b^-/- mice exhibited differences in serum transferrin levels, and more starkly, had markedly smaller spleens indicating defects in stress response. Fam210b^-/- males had defects in neutrophil and monocyte numbers, as well as decreased erythroid progenitor numbers during erythropoietic stress. Together, our findings show that Fam210b plays a key role in splenic response to erythropoietic stress. Our findings reveal a critical role for FAM210B in mediating splenic stress erythropoiesis and suggest it may act as a sex-specific regulator potentially linked to androgen signaling.</p>","PeriodicalId":12202,"journal":{"name":"Experimental hematology","volume":" ","pages":"104797"},"PeriodicalIF":2.5,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of peri-transplant measurable residual disease clearance in patients with myelodysplastic neoplasm; a referral center experience: Effect of peri-HSCT MRD Clearance in MDS.","authors":"Kittika Poonsombudlert, Sarah Mott, Ratdanai Yodsuwan, Andrew Vegel, Aditya Ravindra, Prajwal Dhakal, Grerk Sutamtewagul, Margarida Magalhaes-Silverman","doi":"10.1016/j.exphem.2025.104799","DOIUrl":"https://doi.org/10.1016/j.exphem.2025.104799","url":null,"abstract":"<p><p>Peri-allogeneic stem cell transplant (peri-HSCT) measurable residual disease (MRD) is increasingly recognized as a prognostic marker. However, the MRD status in myelodysplastic neoplasm (MDS) or myelodysplastic/myeloproliferative neoplasm (MDS/MPN), are less well-established compared to B-Acute Lymphoblastic Leukemia. We reviewed the charts of adults who underwent HSCT for MDS or MDS/MPN between 2012-2023 and evaluated the effect of pre-HSCT MRD status on relapse-free and overall survival (RFS and OS). A conditional analysis of outcomes based on day+90 post-HSCT MRD status was also performed. There were 38 and 55 patients in MRD- and MRD+ cohorts respectively. Baseline patient characteristics, including age, Revised and Molecular International Prognostic Scores (IPSS-R & IPSS-M), and HSCT-related factors were similar between MRD+ and MRD- cohort. The MRD+ cohort had inferior RFS (HR: 1.84, 95% CI: 1.09-3.12, p=0.02) but a statistically significant difference in OS was not evidenced (HR: 1.52, 95% CI: 0.88-2.61, p=0.14). After adjusting for % blasts at diagnosis, and conditioning intensity, MRD+ patients were found to be at 1.92 times increased risk of relapse or death (95% CI: 1.12-3.28, p=0.02). Additionally, increasing IPSS-M score was associated with poorer RFS (HR: 1.27, 95% CI: 1.01-1.59, p=0.04) and OS (HR: 1.52, 95% CI: 1.20-1.91, p<0.01). Among patients who were alive and in remission until day +90 post-HSCT, the pre-HSCT MRD status did not confer a statistically significant difference in RFS and OS if they became MRD- by day +90 post-HSCT. Pre- and peri-HSCT MRD testing could offer valuable prognostic information in patients with MDS and MDS/MPN. Teaser Abstract: Not overall survival (OS) but relapse free survival (RFS) can be affected by pre-allogeneic stem cell transplant (pre-HSCT) measurable residual disease (MRD) clearance in patients with myelodysplastic neoplasm (MDS) but more importantly, there is no significant difference in OS and RFS in patients who achieve MRD negative complete remission by day+90 post-HSCT. Graft-versus-tumor effect may exert its effect later in the HSCT course, and clearance of MRD pre-HSCT alone may not reliably predict HSCT outcomes. Post-HSCT MRD surveillance should be performed routinely in MDS patients.</p>","PeriodicalId":12202,"journal":{"name":"Experimental hematology","volume":" ","pages":"104799"},"PeriodicalIF":2.5,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vesicle-Mediated Information Transfer in Cardiovascular Cell Differentiation.","authors":"Jun K Yamashita","doi":"10.1016/j.exphem.2025.104800","DOIUrl":"https://doi.org/10.1016/j.exphem.2025.104800","url":null,"abstract":"<p><p>Extracellular vesicles (EVs)-including exosomes, microvesicles, and apoptotic bodies-are membrane-bound carriers of diverse molecular cargo such as nucleic acids, proteins, and lipids. They are increasingly recognized as critical mediators of information transfer during cardiovascular cell differentiation, development, diseases, and regeneration. Emerging evidence highlights the capacity of EV-encapsulated miRNAs to drive cardiomyocyte differentiation and support angiogenesis. We recently discovered a novel EV-mediated mechanism termed \"Phenotypic Synchronization of Cells\" (PSyC). When Protein Kinase A (PKA) is activated in pluripotent stem cells, the speed of mesodermal differentiation increases, partly through elevated EV-encapsulated miR-132. miR-132, transferred to neighboring cells with EVs, reactivates PKA signaling in recipient cells, synchronizing differentiation stages. Additionally, ex vivo assays reveal that EVs derived from PKA-activated cells can induce cardiomyocyte differentiation in early-stage embryos, underscoring the potency of EV-based signaling in shaping cardiovascular phenotypes. We recently uncovered a novel modality of vesicle-mediated intercellular communication, named Direct Intercellular Vesicle Exchange (DIVE), a distinct pathway enabling rapid and direct vesicle transfer between adjacent cells. By facilitating direct traverse of nucleic acid-laden vesicles across the plasma membrane, DIVE may reinforce conventional EV-based signaling in cardiovascular differentiation. Together, these findings underscore the fundamental role of vesicle-mediated information exchange in orchestrating cardiac and vascular cell fates. Exploiting vesicle-mediated communication may open new avenues in regenerative medicine, disease modeling, and therapeutic interventions aimed at modulating cardiovascular cell function. We recently uncovered a novel modality of vesicle-mediated intercellular communication, named Direct Intercellular Vesicle Exchange (DIVE), a distinct pathway enabling rapid and direct vesicle transfer between adjacent cells. By facilitating direct traverse of nucleic acid-laden vesicles across the plasma membrane, DIVE may reinforce conventional EV-based signaling in cardiovascular differentiation.</p>","PeriodicalId":12202,"journal":{"name":"Experimental hematology","volume":" ","pages":"104800"},"PeriodicalIF":2.5,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NAMPT-mediated deacetylation of HCLS1 protein promotes clonogenic growth of pediatric CML cells.","authors":"Bardia Samareh, Olga Klimenkova, Narges Aghaallaei, Lijuan Cheng, Andrew Zikic, Houra Loghmani, Patrick Müller, Meinolf Suttorp, Karl Welte, Julia Skokowa, Tatsuya Morishima","doi":"10.1016/j.exphem.2025.104801","DOIUrl":"https://doi.org/10.1016/j.exphem.2025.104801","url":null,"abstract":"<p><p>Pediatric chronic myeloid leukemia (CML) is a rare hematological malignancy with biological features that differ from that of adult patients. In pediatric CML patients the burden of tumor cells is higher resulting in a delayed achievement of deep molecular response (DMR) upon treatment with tyrosine kinase inhibitors (TKIs, e.g. imatinib) than what has been reported in adults. Therefore, the probability to develop resistance to TKIs in children with CML is higher than in adults due to much longer exposure to TKIs. Moreover, in children with CML, long-term treatment with imatinib causes hematologic and non-hematologic toxicities. Improvements of CML therapy in pediatric patients based on the targeting of hematopoiesis-specific BCR::ABL1 downstream effectors are needed. Here, we report elevated levels of the Nicotinamide phosphoribosyltransferase (NAMPT) in mononuclear cells of chronic phase CML (CP-CML) pediatric patients and in blastic phase CML cell lines. NAMPT inhibition abrogated in vitro clonogenic capacity and proliferation of CML cells. NAMPT deacetylates and activates the hematopoietic-specific lyn-substrate 1 (HCLS1) protein, which is essential for the proliferation of CML cells. Moreover, IL1RAP - a marker of myeloid leukemia initiating cells - and LEF-1 - a transcription factor of Wnt signaling - are downstream targets of NAMPT/HCLS1 pathway. Together, our results reveal new treatment avenues of pediatric CML patients by targeting NAMPT-mediated deacetylation of the hematopoietic-specific HCLS1 protein. Teaser Abstract Pediatric chronic myeloid leukemia (CML) patients need long-term tyrosine kinase inhibitor treatment which causes toxicities. Therefore, improvements of CML therapy in pediatric patients are needed. Here, we report elevated levels of the Nicotinamide phosphoribosyltransferase (NAMPT) in chronic phase pediatric CML cells. NAMPT inhibition abrogated in vitro clonogenic capacity and proliferation of CML cells. NAMPT deacetylates and activates the hematopoietic-specific lyn-substrate 1 (HCLS1) protein. Moreover, IL1RAP - a marker of myeloid leukemia initiating cells - is a downstream target of NAMPT/HCLS1 pathway. Together, our results reveal new treatment avenues of pediatric CML patients.</p>","PeriodicalId":12202,"journal":{"name":"Experimental hematology","volume":" ","pages":"104801"},"PeriodicalIF":2.5,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ontogeny, dynamics, and characteristics of neutrophils during the perinatal period.","authors":"Ryo Ishiwata","doi":"10.1016/j.exphem.2025.104798","DOIUrl":"https://doi.org/10.1016/j.exphem.2025.104798","url":null,"abstract":"<p><p>This review examines the dynamic development and unique characteristics of neutrophils during the perinatal period, a critical window when the immune system undergoes rapid reprogramming, based on the mouse studies. In the mouse fetal liver-the primary hematopoietic niche before birth-hematopoietic stem cells and progenitor cells expand in parallel, with granulocyte-monocyte progenitors preferentially differentiating into neutrophils during late gestation. This process, partly driven by granulocyte colony-stimulating factor (G-CSF), substantially increases the number of neutrophils, preparing the neonates for microbial challenges after birth. After birth, there is a surge in circulating neutrophils, likely due to the mobilization of neutrophils from the liver, followed by a microbiota-dependent activation of granulopoiesis in the bone marrow. In addition to their antimicrobial functions, neonatal neutrophils exhibit immunomodulatory characteristics, such as reduced pro-inflammatory signaling and diminished neutrophil extracellular trap formation. These traits may contribute to tolerance to the microbes and help mitigate excessive inflammation. Finally, unresolved issues related to the phenotypic diversity and precise physiological roles of neutrophils during the perinatal period are addressed, highlighting the need for further research. Teaser abstract This review examines the dynamic development of neutrophils during the perinatal period, mainly based on the mouse studies. In the mouse fetal liver, hematopoietic stem and progenitor cells expand in parallel, and neutrophils massively accumulate, preparing neonates for postnatal microbial challenges. After birth, neutrophil numbers surge due to liver mobilization and subsequent microbiota-driven bone marrow granulopoiesis. In addition to their antimicrobial role, neonatal neutrophils display immunomodulatory features that may help control excessive inflammation. Unresolved issues regarding their diversity and functions are addressed.</p>","PeriodicalId":12202,"journal":{"name":"Experimental hematology","volume":" ","pages":"104798"},"PeriodicalIF":2.5,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Notch1 activation and inhibition in T cell acute lymphoblastic leukemia subtypes.","authors":"Jiawen Lu, Xiuhua Xue, Haitao Wang, Ying Hao, Qiong Yang","doi":"10.1016/j.exphem.2025.104771","DOIUrl":"https://doi.org/10.1016/j.exphem.2025.104771","url":null,"abstract":"<p><p>T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy caused by the accumulation of genomic lesions that affect the development of T cells. Notch1 signaling controls the expression of numerous T-lineage genes, thus playing essential parts in T cell differentiation. T-ALL can be classified into two subtypes according to the immunophenotypic and genetic makeup: early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) and non-ETP ALL. The relationship between constitutive activation of Notch1 signaling and non-ETP ALL has been thoroughly studied, while how Notch1 signaling influences ETP ALL still remains unclear. Targeting Notch1 signaling is a promising treatment in T-ALL, and γ-secretase inhibitors (GSIs), which prevents Notch1 signaling from being activated, shows a degree of antineoplastic activity in previous clinical development. But these agents just have satisfactory effects in non-ETP ALL, further study should be carried out to investigate fitting targeting drugs.</p>","PeriodicalId":12202,"journal":{"name":"Experimental hematology","volume":" ","pages":"104771"},"PeriodicalIF":2.5,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A distinct alternative mRNA splicing profile identifies the oncogenic CD44 transcript variant 3 in KMT2A-rearranged pediatric T-cell acute lymphoblastic leukemia cells","authors":"Amanda Ramilo Amor ,&nbsp;Sabina Enlund ,&nbsp;Indranil Sinha ,&nbsp;Qingfei Jiang ,&nbsp;Ola Hermanson ,&nbsp;Anna Nilsson ,&nbsp;Shahrzad Shirazi Fard ,&nbsp;Frida Holm","doi":"10.1016/j.exphem.2025.104712","DOIUrl":"10.1016/j.exphem.2025.104712","url":null,"abstract":"<div><div>T-cell acute lymphoblastic leukemia (T-ALL), which constitutes of 10–15% of all pediatric acute lymphoblastic leukemia (ALL) cases, is known for its complex pathology due to pervasive genetic and chromosomal abnormalities. Although most children are successfully cured, chromosomal rearrangements involving the KMT2A gene is considered a poor prognostic factor. In a cohort of 171 pediatric T-ALL samples, we have studied differences in gene and splice variant patterns in KMT2A-rearranged (KMT2A-r) T-ALL compared with KMT2A-negative (KMT2A-wt) T-ALL samples. Our results have identified a distinct gene expression and splice variant expression pattern in pediatric KMT2A-r patient samples including significant expression of splicing regulatory markers ESRP1 and MBNL3. Additionally, the prosurvival long transcript variant of BCL2 were upregulated in KMT2A-r compared with KMT2A-wt T-ALL samples. Lastly, increased levels of activating methylation in the promoter region of CD44 were identified followed by an upregulation of the oncogenic transcript variant CD44v3 in KMT2A-r T-ALL. Together, this suggests that CD44v3 could play a potential role as gene expression–based risk stratification of KMT2A-r T-ALL and could possibly serve as a therapeutic target using splicing modulators.</div></div>","PeriodicalId":12202,"journal":{"name":"Experimental hematology","volume":"145 ","pages":"Article 104712"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142964310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advantages and challenges of ex vivo generation and expansion of human hematopoietic stem cells from pluripotent stem cells","authors":"Min Ding ,&nbsp;Yu Lu ,&nbsp;Quan-Kai Lei ,&nbsp;Yun-Wen Zheng","doi":"10.1016/j.exphem.2025.104752","DOIUrl":"10.1016/j.exphem.2025.104752","url":null,"abstract":"<div><div>Hematopoietic stem cell transplantation (HSCT) is an essential and increasing therapeutic approach for treating conditions such as leukemia, lymphoma, and other blood cancers. However, its widespread use faces significant challenges, including limited donor availability, pathogens, and the risk of immune rejection. The emergence of pluripotent stem cells (PSCs) offers a potential solution to these challenges. By enabling the generation of hematopoietic stem cells (HSCs) and blood cells in vitro, PSCs open pathways to address the limitations of traditional HSC sources. Self-induced or gene-edited PSCs from patients may provide an accessible and personalized option for clinical applications. In this review, we examine the current protocols for differentiating PSCs into HSCs and blood cells, highlighting their benefits and shortcomings. Despite advancements in this field, two primary challenges persist: low differentiation efficiency and difficulties in isolating and enriching functional HSCs. These problems make it difficult to obtain HSCs for long-term survival. Thus, we propose innovative strategies and potential improvements including induction scheme optimization, reprogramming, and cell fate tracking. Future research should prioritize the development of efficient and reliable differentiation protocols for PSCs to obtain more functional HSCs. Additionally, establishing effective methods for enriching functional HSCs and blood cells will be critical for optimizing their use in clinical applications. These efforts hold the promise of overcoming current limitations and advancing the therapeutic potential of PSC-derived blood cells.</div></div>","PeriodicalId":12202,"journal":{"name":"Experimental hematology","volume":"145 ","pages":"Article 104752"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences alter primitive progenitors in the C57BL/6 Tet2 knockout mouse model","authors":"Samantha M. Holmes ,&nbsp;Christopher J. Wells ,&nbsp;Christine Hall ,&nbsp;Amy J.M. McNaughton ,&nbsp;Michael J. Rauh ,&nbsp;Sheela A. Abraham","doi":"10.1016/j.exphem.2025.104747","DOIUrl":"10.1016/j.exphem.2025.104747","url":null,"abstract":"<div><div>The precancerous expansion of hematopoietic cells, termed clonal hematopoiesis (CH), has been correlated to disease development and all-cause mortality. Despite multiple observations that hematopoietic stem cell and progenitors (HSPCs) are significantly affected by both sex and age, there remain few studies quantifying male and female HSPC populations in wild-type and transgenic <em>Tet2</em> models over time. Here, we determine that male mice (with a hematopoietic deficiency of <em>Tet2</em> and control) have more Lin⁻Sca-1⁺c-kit⁺ (LSK) cells, that include multipotent progenitor cells (MPPs; LSK CD48⁻CD150⁻) and long-term hematopoietic stem cells (LT-HSC; LSK CD48⁻CD150⁺) compared with females. LT-HSC, MPP, and progenitor populations were observed to possess equal male/female ratios in mice at 6 weeks of age; however, the LSK compartment was found most susceptible to sex-based effects in transgenic mice between 6 weeks and 4 months. In contrast, all differentiated progenitor populations analyzed in mice were observed to be unaffected by sex between 6 weeks to 4 months. This study provides a comprehensive analysis of bone-sourced HSPCs in <em>Tet2</em>-deficient mouse models and reveals important sex and age considerations that must be taken into account when using C57BL/6 mice for transgenic studies.</div></div>","PeriodicalId":12202,"journal":{"name":"Experimental hematology","volume":"145 ","pages":"Article 104747"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IFC Editorial Board","authors":"","doi":"10.1016/S0301-472X(25)00064-5","DOIUrl":"10.1016/S0301-472X(25)00064-5","url":null,"abstract":"","PeriodicalId":12202,"journal":{"name":"Experimental hematology","volume":"145 ","pages":"Article 104773"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143886340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}