基因调控复合体:它们在正常和恶性造血中的作用和调控。

IF 2.5 4区 医学 Q2 HEMATOLOGY
Gina Sangha , Brian J.P. Huntly
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引用次数: 0

摘要

转录以多种方式调节,以确保谱系和上下文特定的基因以协调的方式表达。造血是通过转录和基因调控复合物来研究基因表达程序受到严格调控的激活和抑制机制的典型过程。这些复合物通过组蛋白和非组蛋白的翻译后修饰、DNA的表观遗传修饰、atp依赖性染色质重塑、组合蛋白复合物的支架和募集以及三维基因组构象的改变来实现谱系特异性基因表达。本文综述了这些基因调控复合物在造血中的功能,以及它们在急性髓性白血病中是如何被劫持的,重点介绍了治疗进展和机会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Gene regulatory complexes: their role and regulation across normal and malignant hematopoiesis

Gene regulatory complexes: their role and regulation across normal and malignant hematopoiesis
Transcription is regulated in a multitude of ways to ensure lineage- and context-specific gene expression in a coordinated fashion. Hematopoiesis is an exemplary process for studying the mechanisms of tightly regulated activation and repression of gene expression programs through transcription and gene regulatory complexes. These complexes act by posttranslational modification of histones and nonhistone proteins, epigenetic modifications of DNA, ATP-dependent chromatin remodeling, scaffolding and recruitment of combinatorial protein complexes, and alteration of three-dimensional genome conformation to bring about lineage-specific gene expression. This review will focus on the function of these gene regulatory complexes in hematopoiesis and how they are hijacked in acute myeloid leukemia, highlighting therapeutic progress and opportunities.
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来源期刊
Experimental hematology
Experimental hematology 医学-血液学
CiteScore
5.30
自引率
0.00%
发文量
84
审稿时长
58 days
期刊介绍: Experimental Hematology publishes new findings, methodologies, reviews and perspectives in all areas of hematology and immune cell formation on a monthly basis that may include Special Issues on particular topics of current interest. The overall goal is to report new insights into how normal blood cells are produced, how their production is normally regulated, mechanisms that contribute to hematological diseases and new approaches to their treatment. Specific topics may include relevant developmental and aging processes, stem cell biology, analyses of intrinsic and extrinsic regulatory mechanisms, in vitro behavior of primary cells, clonal tracking, molecular and omics analyses, metabolism, epigenetics, bioengineering approaches, studies in model organisms, novel clinical observations, transplantation biology and new therapeutic avenues.
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