{"title":"Gene Regulatory Complexes: their role and regulation across normal and malignant haematopoiesis.","authors":"Gina Sangha, Brian Jp Huntly","doi":"10.1016/j.exphem.2025.104821","DOIUrl":null,"url":null,"abstract":"<p><p>Transcription is regulated in a multitude of ways to ensure lineage- and context-specific gene expression in a co-ordinated fashion. Haematopoiesis is an exemplar process for studying the mechanisms of tightly regulated activation and repression of gene expression programmes by transcription and gene regulatory complexes. These complexes act by post-translational modification of histones and non-histone proteins, epigenetic modifications of DNA, ATP-dependent chromatin remodelling, scaffolding and recruitment of combinatorial protein complexes and alteration of three-dimensional genome conformation to bring about lineage-specific gene expression. This review focusses on the function of these gene regulatory complexes in haematopoiesis and how they are hijacked in Acute Myeloid Leukaemia, highlighting therapeutic progress and opportunities.</p>","PeriodicalId":12202,"journal":{"name":"Experimental hematology","volume":" ","pages":"104821"},"PeriodicalIF":2.5000,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experimental hematology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.exphem.2025.104821","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"HEMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Transcription is regulated in a multitude of ways to ensure lineage- and context-specific gene expression in a co-ordinated fashion. Haematopoiesis is an exemplar process for studying the mechanisms of tightly regulated activation and repression of gene expression programmes by transcription and gene regulatory complexes. These complexes act by post-translational modification of histones and non-histone proteins, epigenetic modifications of DNA, ATP-dependent chromatin remodelling, scaffolding and recruitment of combinatorial protein complexes and alteration of three-dimensional genome conformation to bring about lineage-specific gene expression. This review focusses on the function of these gene regulatory complexes in haematopoiesis and how they are hijacked in Acute Myeloid Leukaemia, highlighting therapeutic progress and opportunities.
期刊介绍：
Experimental Hematology publishes new findings, methodologies, reviews and perspectives in all areas of hematology and immune cell formation on a monthly basis that may include Special Issues on particular topics of current interest. The overall goal is to report new insights into how normal blood cells are produced, how their production is normally regulated, mechanisms that contribute to hematological diseases and new approaches to their treatment. Specific topics may include relevant developmental and aging processes, stem cell biology, analyses of intrinsic and extrinsic regulatory mechanisms, in vitro behavior of primary cells, clonal tracking, molecular and omics analyses, metabolism, epigenetics, bioengineering approaches, studies in model organisms, novel clinical observations, transplantation biology and new therapeutic avenues.
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