Expert Review of Clinical Immunology最新文献_第2页

Should esophageal string test be used to monitor inflammation in EoE? 食管弦试验是否可以用于监测EoE的炎症？

IF 3.7 3区医学

Expert Review of Clinical Immunology Pub Date : 2026-04-17 DOI: 10.1080/1744666X.2026.2659683

Anita M Husain, Colby Sharlin, Shauna Schroeder

引用次数: 0

Interleukin-33/ST2 axis in Kawasaki disease: biology, vascular pathology, and future therapeutic strategies. 白介素-33/ST2轴在川崎病中的作用：生物学、血管病理学和未来治疗策略

IF 3.7 3区医学

Expert Review of Clinical Immunology Pub Date : 2026-04-13 DOI: 10.1080/1744666X.2026.2655165

Seigo Okada, Pui Y Lee, Hiroki Yasudo, Yuji Ohnishi, Mary Beth F Son, Jane W Newburger, Shunji Hasegawa

{"title":"Interleukin-33/ST2 axis in Kawasaki disease: biology, vascular pathology, and future therapeutic strategies.","authors":"Seigo Okada, Pui Y Lee, Hiroki Yasudo, Yuji Ohnishi, Mary Beth F Son, Jane W Newburger, Shunji Hasegawa","doi":"10.1080/1744666X.2026.2655165","DOIUrl":"10.1080/1744666X.2026.2655165","url":null,"abstract":"Introduction: Kawasaki disease (KD) is an acute systemic vasculitis of childhood and the leading cause of acquired heart disease in developed countries. Coronary artery abnormalities (CAAs), the major clinical sequelae of KD, remain major clinical challenges, which highlights the need for deeper mechanistic insights.Areas covered: This review summarizes current knowledge of the interleukin-33 (IL-33)/suppression of tumorigenicity 2 (ST2) axis in the context of KD. We discuss the molecular biology of IL-33 and its receptors, downstream signaling pathways, and cell-type-specific immunological and vascular effects. Evidence from clinical studies, biomarker analyses, and experimental KD models is integrated to delineate the potential contribution of IL-33/ST2 signaling to coronary arteritis. Relevant literature was identified through comprehensive searches of major biomedical databases focusing on KD, vasculitis, IL-33, ST2, and related therapeutic strategies. Literature was identified via PubMed and ClinicalTrials.gov.Expert opinion: Current evidence supports the IL-33/ST2 axis as a plausible, context-dependent modulatory pathway linking tissue injury, innate immune activation, and vascular inflammation in KD. Soluble ST2 shows particular promise as a biomarker reflecting disease activity and cardiac stress. Targeted modulation of IL-33/ST2 signaling, guided by disease phase and biomarker profiles, could represent a next-generation therapeutic approach to prevent CAAs in KD.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"1-19"},"PeriodicalIF":3.7,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing response to biological therapies in severe asthma. 评估严重哮喘患者对生物疗法的反应。

IF 3.7 3区医学

Expert Review of Clinical Immunology Pub Date : 2026-04-03 DOI: 10.1080/1744666X.2026.2655162

Angelantonio Maglio, Carolina Vitale, Luisa Oriana D'Auria, Valeria Longobardi, Antonio Franzese, Corrado Pelaia, Girolamo Pelaia, Alessandro Vatrella

{"title":"Assessing response to biological therapies in severe asthma.","authors":"Angelantonio Maglio, Carolina Vitale, Luisa Oriana D'Auria, Valeria Longobardi, Antonio Franzese, Corrado Pelaia, Girolamo Pelaia, Alessandro Vatrella","doi":"10.1080/1744666X.2026.2655162","DOIUrl":"https://doi.org/10.1080/1744666X.2026.2655162","url":null,"abstract":"Introduction: The management of severe asthma has shifted toward precision medicine, with clinical remission emerging as the ultimate therapeutic goal. This review evaluates the transition from predicting treatment response to achieving sustained remission through biologics.Areas covered: A comprehensive literature search was conducted in PubMed and Embase for articles published between January 2015 and February 2026. Keywords included 'severe asthma,' 'biologic therapies,' 'clinical remission,' and 'T2 biomarkers.' We analyze the predictive value of blood eosinophils (BEC), FeNO, and emerging indicators like CT-based mucus plugs. The review synthesizes data on 'super-responders' and the integration of real-world evidence into clinical practice.Expert opinion: Achieving clinical remission requires a multidimensional assessment beyond symptom control, including lung function stability and OCS elimination. Future management will likely focus on 'disease modification' and early biologic intervention. The identification of specific phenotypes, such as those with high mucus-plug burdens, will allow for more tailored therapy. However, standardized criteria for 'remission off-treatment' remain the primary challenge for the next decade of respiratory research.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"1-12"},"PeriodicalIF":3.7,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147616092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in the pathogenesis of neuropsychiatric systemic lupus erythematosus. 神经精神系统红斑狼疮发病机制研究进展。

IF 3.7 3区医学

Expert Review of Clinical Immunology Pub Date : 2026-03-26 DOI: 10.1080/1744666X.2026.2650332

Kohei Karino, Michihito Kono

{"title":"Recent advances in the pathogenesis of neuropsychiatric systemic lupus erythematosus.","authors":"Kohei Karino, Michihito Kono","doi":"10.1080/1744666X.2026.2650332","DOIUrl":"10.1080/1744666X.2026.2650332","url":null,"abstract":"Introduction: Neuropsychiatric systemic lupus erythematosus (NPSLE) is a highly heterogeneous and clinically challenging manifestation of systemic lupus erythematosus, encompassing a broad spectrum of diffuse and focal neuropsychiatric symptoms. Conventional models have emphasized vascular injury and blood-brain barrier (BBB) dysfunction; however, these frameworks alone do not fully account for phenotypic diversity, frequent absence of overt structural lesions, or variable associations with systemic disease activity.Areas covered: This review summarizes recent advances in the understanding of immune cell infiltration, resident central nervous system (CNS) cell responses, cytokine and chemokine networks, autoantibody-mediated effects, and CNS barrier-related mechanisms in NPSLE. We discuss how interactions among barrier systems, microglial activation, astrocytic reactivity, neuronal vulnerability, and context-dependent autoantibody effects collectively shape CNS pathology. Relevant literature was identified through searches of the PubMed database for studies published up to January 2026 focusing on neuroimmune mechanisms, cytokine networks, CNS barrier dysfunction, and autoantibody-mediated neuronal injury in NPSLE.Expert opinion: Integrating these processes within a neuroimmune framework highlights the importance of barrier-associated mechanisms in linking systemic autoimmunity to CNS-specific disease. This perspective supports mechanism-informed stratification and may inform future diagnostic approaches and targeted therapeutic strategies in NPSLE.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"1-10"},"PeriodicalIF":3.7,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147503653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbiome and EGFR-mutant non-small cell lung cancer: a complex interplay. 微生物组和egfr突变的非小细胞肺癌：复杂的相互作用。

IF 3.7 3区医学

Expert Review of Clinical Immunology Pub Date : 2026-03-16 DOI: 10.1080/1744666X.2026.2645844

Serena Eccher, Marco Sposito, Ilaria Mariangela Scaglione, Luca Pasqualin, Michele Rota, Adele Bonato, Lucia Longo, Alice Avancini, Ilaria Trestini, Daniela Tregnago, Jessica Insolda, Michele Milella, Sara Pilotto, Lorenzo Belluomini

{"title":"Microbiome and EGFR-mutant non-small cell lung cancer: a complex interplay.","authors":"Serena Eccher, Marco Sposito, Ilaria Mariangela Scaglione, Luca Pasqualin, Michele Rota, Adele Bonato, Lucia Longo, Alice Avancini, Ilaria Trestini, Daniela Tregnago, Jessica Insolda, Michele Milella, Sara Pilotto, Lorenzo Belluomini","doi":"10.1080/1744666X.2026.2645844","DOIUrl":"10.1080/1744666X.2026.2645844","url":null,"abstract":"Introduction: Epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) exhibits unique biological and therapeutic characteristics. Although EGFR tyrosine kinase inhibitors (EGFR-TKIs) offer substantial clinical benefits, resistance development and treatment-related toxicities remain major challenges. Emerging evidence indicates that the host microbiome may significantly influence the efficacy and tolerability of EGFR-targeted therapies.Areas covered: This review summarizes the main microbiome characteristics of EGFR-mutant NSCLC and discusses the interplay between gut, respiratory and intratumoral microbiome, and EGFR-TKI therapy in NSCLC, highlighting differential microbiome shifts associated with different TKIs and comparing the role of microbiome in modulating responses to EGFR-TKIs. The review also explores preclinical and early clinical strategies aimed at enhancing TKI efficacy and at, potentially, improving sensitivity of EGFR-mutant NSCLC to immunotherapy.Expert opinion: Despite its emerging role, microbiome research in EGFR-mutant NSCLC holds substantial potential to refine therapeutic outcomes. Microbiota-targeted interventions may improve TKIs efficacy, mitigate toxicity, and potentially expand immunotherapeutic options in this molecularly and immunologically 'cold' subgroup. Future integrative studies combining microbiome, metabolome, and immune profiling are essential to translate these insights into personalized clinical strategies.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"1-12"},"PeriodicalIF":3.7,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond the binary: understanding inflammatory bowel disease in the context of HIV-induced immunodeficiency. 超越二元：在hiv诱导免疫缺陷的背景下理解炎症性肠病。

IF 3.7 3区医学

Expert Review of Clinical Immunology Pub Date : 2026-03-13 DOI: 10.1080/1744666X.2026.2642832

Harsh Srivastava, Tanisha Sehgal, Vishal Sharma, Himanshu Narang, Jeffrey Berinstein, Ajit Sood, Shrinivas Bishu, Manjeet Kumar Goyal

{"title":"Beyond the binary: understanding inflammatory bowel disease in the context of HIV-induced immunodeficiency.","authors":"Harsh Srivastava, Tanisha Sehgal, Vishal Sharma, Himanshu Narang, Jeffrey Berinstein, Ajit Sood, Shrinivas Bishu, Manjeet Kumar Goyal","doi":"10.1080/1744666X.2026.2642832","DOIUrl":"10.1080/1744666X.2026.2642832","url":null,"abstract":"Introduction: The coexistence of inflammatory bowel disease (IBD) and human immunodeficiency virus (HIV) represents a clinical paradox in which immune hyperactivity coexists with persistent immunodeficiency. Improved survival with antiretroviral therapy (ART) has led to increasing co-diagnoses, creating complex diagnostic and therapeutic challenges.Areas covered: A comprehensive literature search of PubMed/MEDLINE, Embase, Scopus, and the Cochrane Library from inception through December 2024 was conducted, supplemented by major gastroenterology and infectious disease conference proceedings through April 2025. This review synthesizes contemporary evidence on epidemiology, immunopathogenesis, clinical presentation, and management of IBD in people living with HIV. Key themes include immune reconstitution and Th17-cell depletion, diagnostic differentiation from infectious and noninfectious mimickers, underutilization of advanced IBD therapies despite emerging safety data, bidirectional interactions between intestinal inflammation and HIV viral dynamics, and clinically relevant ART - IBD interactions requiring multidisciplinary care.Expert opinion: Accumulating evidence supports the safe and appropriate use of immune-modulating therapies in virologically suppressed HIV-positive patients with IBD, challenging historical risk-averse approaches. Optimal management requires precision-based strategy incorporating CD4+ cell thresholds, mucosal and inflammatory biomarkers, and individualized risk stratification. Future priorities include standardized diagnostic algorithms, longitudinal registries integrating immunological and virological parameters, and improved access to advanced therapies, moving beyond the traditional autoimmunity - immunodeficiency binary.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"1-15"},"PeriodicalIF":3.7,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147369499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The spectrum of autoimmune disorders in chronic immune-mediated neuropathies. 慢性免疫介导的神经病变的自身免疫性疾病谱。

IF 3.7 3区医学

Expert Review of Clinical Immunology Pub Date : 2026-03-10 DOI: 10.1080/1744666X.2026.2641535

Joumana Freiha, Young Gi Min, Yusuf A Rajabally, Chinar Osman

{"title":"The spectrum of autoimmune disorders in chronic immune-mediated neuropathies.","authors":"Joumana Freiha, Young Gi Min, Yusuf A Rajabally, Chinar Osman","doi":"10.1080/1744666X.2026.2641535","DOIUrl":"10.1080/1744666X.2026.2641535","url":null,"abstract":"Introduction: Autoimmune disorders frequently cluster within individuals, a phenomenon known as polyautoimmunity, yet its scope and implications in chronic immune-mediated neuropathies remain underexplored.Areas covered: This review examines the association between chronic immune-mediated neuropathies and broader systemic autoimmunity to highlight the immunopathological mechanisms driving these associations, and clinical implications for diagnosis, prognosis, and treatment. A comprehensive literature search was conducted using PubMed and Embase databases for studies published up to October 2025 employing terms related to autoimmune neuropathies, polyautoimmunity, and associated systemic autoimmune diseases.Expert opinion: While autoimmune comorbidities in CIN are often viewed as confounding conditions for diagnosis, they may indicate a broader, systemic immune dysregulation. Adopting this perspective has direct clinical relevance. Proactive screening for associated autoimmune disorders is essential, as their presence can shape disease trajectory and modify treatment responsiveness. Furthermore, uncovering shared pathological pathways between CIN and these coexisting conditions may open avenues for therapeutic strategies that simultaneously target both neuropathic and systemic manifestations. To advance this field, future research may allow discovery of biomarkers that could stratify patients based on their distinct underlying immune drivers, which may pave the way for a precision medicine approach in this clinically heterogeneous population.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"1-14"},"PeriodicalIF":3.7,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147376468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 修正。

IF 3.7 3区医学

Expert Review of Clinical Immunology Pub Date : 2026-02-01 Epub Date: 2025-12-25 DOI: 10.1080/1744666X.2025.2610047

引用次数: 0

Malignancies in the context of Inborn errors of immunity: an immunologist's view. 恶性肿瘤在先天性免疫错误的背景下：免疫学家的观点。

IF 3.7 3区医学

Expert Review of Clinical Immunology Pub Date : 2026-02-01 Epub Date: 2026-02-22 DOI: 10.1080/1744666X.2026.2633137

Zehra Genc Ozbay, Elif Soyak Aytekin, Saliha Esenboga, Deniz Cagdas

{"title":"Malignancies in the context of Inborn errors of immunity: an immunologist's view.","authors":"Zehra Genc Ozbay, Elif Soyak Aytekin, Saliha Esenboga, Deniz Cagdas","doi":"10.1080/1744666X.2026.2633137","DOIUrl":"10.1080/1744666X.2026.2633137","url":null,"abstract":"Introduction: Inborn errors of immunity (IEIs), also known as primary immunodeficiency diseases (PIDs) since 2017 Inborn Errors of Immunity Committee classification, comprise a heterogeneous group of genetic disorders resulting in impaired immune development and function. Malignancy is a major challenge in IEIs, particularly in those with defects in DNA repair, tumor suppression, immune surveillance, or chronic inflammatory control, highlighting the close interplay between immune dysfunction and oncogenesis.Areas covered: Hematologic malignancies, especially non-Hodgkin lymphomas, predominate in IEIs, though epithelial tumors also occur and present at younger ages with poorer outcomes. Both intrinsic factors - such as genomic instability and defective lymphocyte maturation - and extrinsic factors, including chronic inflammation, oncogenic viral infections, and iatrogenic exposures, contribute to cancer development. Subtypes such as ataxia-telangiectasia, Nijmegen breakage syndrome, Wiskott - Aldrich syndrome, and common variable immunodeficiency show particularly high malignancy rates. Defects in specific immune pathways, may predispose to organ-specific or virus-driven cancers.Expert opinion: Although hematopoietic stem cell transplantation remains curative for selective IEIs, post-transplant malignancy risk persists. A deeper understanding of shared molecular pathways linking immunodeficiency and cancer is essential to refine early diagnosis, risk stratification, and targeted management in this vulnerable population.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"223-231"},"PeriodicalIF":3.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146200597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation of a rapid fluorescence immunoassay for soluble interleukin-2 receptor α in a pediatric population. 儿童可溶性白细胞介素-2受体α的快速荧光免疫分析验证。

IF 3.7 3区医学

Expert Review of Clinical Immunology Pub Date : 2026-02-01 Epub Date: 2026-02-27 DOI: 10.1080/1744666X.2026.2637765

Samantha M Logan, Tina Henderson, Mehdi Hooshmandi, Luke Y C Chen, Kristi L Smiley, Rebecca Marsh, Lusia Sepiashvili

{"title":"Validation of a rapid fluorescence immunoassay for soluble interleukin-2 receptor α in a pediatric population.","authors":"Samantha M Logan, Tina Henderson, Mehdi Hooshmandi, Luke Y C Chen, Kristi L Smiley, Rebecca Marsh, Lusia Sepiashvili","doi":"10.1080/1744666X.2026.2637765","DOIUrl":"10.1080/1744666X.2026.2637765","url":null,"abstract":"Introduction: The objective of this study was to assess the analytical performance of an automated fluorescence immunoassay (FIA) on the ProteinSimple Ella for rapid measurement of sIL-2 Rα in pediatrics.Research design and methods: Analytical performance evaluation included imprecision, linearity, accuracy, and reference interval establishment. Accuracy was evaluated via method comparison with a chemiluminescent immunoassay (CMIA) through split sampling of EDTA plasma (n = 28). Reference intervals were established per CLSI guidelines (EP28-A3) using plasma from 222 metabolically stable outpatients aged 0 to 19 years.Results: Imprecision at quality control concentrations of 34 and 1943 pg/mL was 5.0% and 6.9%, respectively. The method was linear across the analytical measuring range. A strong linear correlation between FIA and CMIA (slope: 0.99, bias: -10%, R = 0.99) was found. It was determined that the 2400 U/mL clinical cutoff is equivalent to 10,320 pg/mL. sIL-2 r concentrations were inversely correlated with age. Age-specific reference ranges were established: (1) 0 to <6 years: 1377 - 5022, (2) 6 to <14 years: 851 - 3288, and (3) 565-2499 pg/mL.Conclusions: Characterization of the analytical performance of the automated FIA for sIL-2 Rα measurement and establishment of age-specific reference ranges is expected to facilitate future investigations of this biomarker in children and adolescents.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"243-248"},"PeriodicalIF":3.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147283165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0