Expert Review of Clinical Immunology最新文献

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Immunopathogenesis of IgG4-related disease in the era of single-cell RNA sequencing and highly multiplex immunofluorescence. 单细胞RNA测序和高度多重免疫荧光时代igg4相关疾病的免疫发病机制
IF 3.7 3区 医学
Expert Review of Clinical Immunology Pub Date : 2025-09-29 DOI: 10.1080/1744666X.2025.2567589
Satoshi Hara
{"title":"Immunopathogenesis of IgG4-related disease in the era of single-cell RNA sequencing and highly multiplex immunofluorescence.","authors":"Satoshi Hara","doi":"10.1080/1744666X.2025.2567589","DOIUrl":"10.1080/1744666X.2025.2567589","url":null,"abstract":"<p><strong>Introduction: </strong>IgG4-related disease (IgG4-RD) is a chronic immune-mediated fibroinflammatory disorder characterized by dense lymphoplasmacytic infiltration and storiform fibrosis, often resulting in organ dysfunction. Although glucocorticoids provide initial clinical improvement, relapse is common, underscoring the need for targeted therapies. B-cell depletion therapy has emerged as a promising approach, shedding light on the roles of plasmablasts and cytotoxic T lymphocytes in disease pathogenesis.</p><p><strong>Areas covered: </strong>This review summarizes recent advances in immunological mechanisms of IgG4-RD, focusing on plasmablasts, activated B cells, cytotoxic T lymphocytes, T follicular helper (Tfh) cells, macrophages, dendritic cells, other immune cells, and fibroblasts. We highlight how single-cell RNA sequencing and highly multiplex immunofluorescence have uncovered novel immune subsets and their interactions. These technologies have identified previously unrecognized populations, including GZMK<sup>+</sup> cytotoxic Tfh cells, MKI67<sup>+</sup> B cells, and double-negative type 3 B cells, offering unprecedented resolution into disease mechanisms.</p><p><strong>Expert opinion: </strong>Single-cell technologies have revolutionized our understanding of IgG4-RD immunopathogenesis and potentially revealed disease heterogeneity across clinical phenotypes. These insights hold promise for biomarker development and precision therapeutic strategies. Future directions should include spatial transcriptomics and proteomics, improved animal models, and translational efforts to bridge mechanistic discoveries with targeted treatment for this complex multi-organ disease.</p>","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"1-19"},"PeriodicalIF":3.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Personalization of therapy for patients with eosinophilic esophagitis. 嗜酸性粒细胞性食管炎患者的个性化治疗。
IF 3.7 3区 医学
Expert Review of Clinical Immunology Pub Date : 2025-09-29 DOI: 10.1080/1744666X.2025.2565663
Martina Ottoni, Francesca Nicoletta, Andrea Pederzani, Alessandro Barone, Erminia Ridolo
{"title":"Personalization of therapy for patients with eosinophilic esophagitis.","authors":"Martina Ottoni, Francesca Nicoletta, Andrea Pederzani, Alessandro Barone, Erminia Ridolo","doi":"10.1080/1744666X.2025.2565663","DOIUrl":"10.1080/1744666X.2025.2565663","url":null,"abstract":"<p><strong>Introduction: </strong>The rising global prevalence of eosinophilic esophagitis (EoE) has made it a major topic of interest in both Clinical Immunology and Gastroenterology. Despite advances in understanding its physiopathology, optimal long-term management remains challenging due to disease heterogeneity and variable treatment responses. An integrated, patient-centered approach can be valuable in clinical practice, improving outcomes by tailoring treatment strategies to individual patient needs.</p><p><strong>Areas covered: </strong>This review explores the current therapeutic options of EoE, including proton pump inhibitors (PPIs), topical corticosteroids, elimination diets, and biologic agents, focusing on treatment efficacy, limitations, and patient-centered factors such as quality of life, treatment adherence, and comorbid atopic conditions. The article also examines recent guidelines and the rationale behind personalized therapy approaches. A comprehensive review of the current literature on personalized therapy for EoE has been conducted, highlighting recent developments in treatment strategies and individualized patient care approaches.</p><p><strong>Expert opinion: </strong>There is no one-size-fits-all therapeutic strategy for EoE. Given the complexity of patient profiles, including immunologic phenotypes, psychological attitudes, and socioeconomic factors, therapeutic choices must be personalized. Shared decision-making is essential to align treatment plans with patient values and improve both clinical outcomes and long-term adherence.</p>","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"1-11"},"PeriodicalIF":3.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Periostin as a biomarker of severity and mortality in COVID-19 patients. 骨膜蛋白作为COVID-19患者严重程度和死亡率的生物标志物
IF 3.7 3区 医学
Expert Review of Clinical Immunology Pub Date : 2025-09-25 DOI: 10.1080/1744666X.2025.2566841
Ismail Yigitdol, Erdinc Gulumsek, Kubilay Akbal, Okan Pirinci, Ibrahim Erdem, Huseyin Ali Ozturk, Hilmi Erdem Sumbul
{"title":"Periostin as a biomarker of severity and mortality in COVID-19 patients.","authors":"Ismail Yigitdol, Erdinc Gulumsek, Kubilay Akbal, Okan Pirinci, Ibrahim Erdem, Huseyin Ali Ozturk, Hilmi Erdem Sumbul","doi":"10.1080/1744666X.2025.2566841","DOIUrl":"10.1080/1744666X.2025.2566841","url":null,"abstract":"<p><strong>Background: </strong>Periostin is a novel biomarker associated with a range of inflammatory conditions, particularly those involving pulmonary inflammation and fibrotic processes. This research aimed to investigate the association between periostin concentrations, severity of COVID-19, and patient mortality.</p><p><strong>Research design and methods: </strong>Our study comprised 127 participants: 36 healthy controls (Group-1), 37 COVID-19 patients with uncomplicated disease (Group-2), 28 with mild pneumonia (Group-3), and 26 with severe pneumonia (Group-4). Periostin levels in all participants were measured using the ELISA method.</p><p><strong>Results: </strong>Periostin concentrations were significantly elevated in COVID-19 patients compared to healthy controls (<i>p</i> < 0.001). Periostin concentrations were significantly elevated in patients with severe COVID-19 pneumonia compared to those with mild pneumonia or uncomplicated disease (<i>p</i> < 0.05). According to our study analysis, periostin level independently predicted severe pneumonia in COVID-19 (Odds Ratio: 1.085; 95% CI: 1.035-1.137; <i>p</i> = 0.001). Serum periostin threshold of 67.5 ng/mL predicted severe pneumonia with 69.2% sensitivity and 66.2% specificity. Lastly, every 1 ng/mL increase in periostin was linked to 1.21-fold higher mortality risk in COVID-19 patients with severe pneumonia (Hazard Ratio: 1.216; 95% CI: 1.006-1.471; <i>p</i> = 0.044).</p><p><strong>Conclusion: </strong>Our findings suggest that periostin level may help assessing disease severity and predicting mortality in COVID-19. Additional studies with expanded patient groups are needed.</p>","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"1-7"},"PeriodicalIF":3.7,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rational test request in autoimmune rheumatological disease diagnosis evaluation of immunoblot requests with anti-nuclear antibody indirect immunofluorescence test requests. 自身免疫性风湿病诊断中的合理检测要求免疫印迹评价要求与抗核抗体间接免疫荧光检测要求。
IF 3.7 3区 医学
Expert Review of Clinical Immunology Pub Date : 2025-09-25 DOI: 10.1080/1744666X.2025.2565667
Mehmet Akif Durmuş, Beyza Öncel
{"title":"Rational test request in autoimmune rheumatological disease diagnosis evaluation of immunoblot requests with anti-nuclear antibody indirect immunofluorescence test requests.","authors":"Mehmet Akif Durmuş, Beyza Öncel","doi":"10.1080/1744666X.2025.2565667","DOIUrl":"10.1080/1744666X.2025.2565667","url":null,"abstract":"<p><strong>Background: </strong>This study evaluated clinician adherence to unrestricted antinuclear antibody (ANA) and subserology test requests, comparing rheumatologists and other specialists, and assessed the financial impact of inappropriate orders.</p><p><strong>Research design and methods: </strong>We analyzed 43,691 patients tested for ANA IIF from January 2022 to June 2024. ENA profile immunoblot requests without appropriate ANA IIF positivity were categorized by specialty.</p><p><strong>Results: </strong>Rheumatologists ordered 11,581 ANA IIF tests (26.51%), while non-rheumatology physicians ordered 32,110 (73.49%). Of ANA IIF-negative results, 55.82% had ENA immunoblots, with rheumatologists (73.97%) and non-rheumatologists (50.42%) contributing to unnecessary requests. After implementing reflex testing, specialist training, and ELISA, the ENA immunoblot claim rate decreased from 58.44% to 20% within one year, resulting in an annual savings of €121,000.</p><p><strong>Conclusions: </strong>Reflex testing and laboratory-guided algorithms reduce unnecessary orders, maintain diagnostic accuracy, and achieve significant cost savings through enhanced collaboration between clinicians and laboratories.</p>","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"1-6"},"PeriodicalIF":3.7,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Langerhans Cell Histiocytosis in the central nervous system, cranial and spinal bones: imaging features. 朗格汉斯细胞组织细胞增多症在中枢神经系统,颅和脊柱骨:影像学特征。
IF 3.7 3区 医学
Expert Review of Clinical Immunology Pub Date : 2025-09-23 DOI: 10.1080/1744666X.2025.2564827
Lara Hemerly De Mori, Gabriela Amaral Ribas, Luciane Dos Santos Oliveira, Waldir Heringer Maymone, Luiz Celso Hygino da Cruz Júnior, Tomás de Andrade Lourenção Freddi, Simone Rachid de Souza, Nina Ventura, Diogo Goulart Corrêa
{"title":"Langerhans Cell Histiocytosis in the central nervous system, cranial and spinal bones: imaging features.","authors":"Lara Hemerly De Mori, Gabriela Amaral Ribas, Luciane Dos Santos Oliveira, Waldir Heringer Maymone, Luiz Celso Hygino da Cruz Júnior, Tomás de Andrade Lourenção Freddi, Simone Rachid de Souza, Nina Ventura, Diogo Goulart Corrêa","doi":"10.1080/1744666X.2025.2564827","DOIUrl":"10.1080/1744666X.2025.2564827","url":null,"abstract":"<p><strong>Introduction: </strong>Langerhans Cell Histiocytosis (LCH) is a rare neoplastic disorder characterized by monoclonal proliferation and tissue infiltration by pathological dendritic cells, often associated with abnormal activation of the MAPK signaling pathway and BRAF V600E mutation. The diagnosis is established through clinical, radiological, and histopathological evaluation. It can manifest in various organs, notably bones, skin, and the hypothalamic-pituitary axis. The assessment of central nervous system (CNS) involvement in LCH includes both parenchymal and non-parenchymal structures, including craniofacial bones, hypothalamic-pituitary axis, and meninges.</p><p><strong>Areas covered: </strong>We used the PubMed database and reviewed relevant English-language literature published from 1989 to 2024. The sources included original researches, reviews and case reports, excluding editorials and letters to the editor. This review focuses on the existing evidence regarding the imaging, clinical, and pathological aspects of CNS, cranial and spinal bones involvement in LCH and its differential diagnosis.</p><p><strong>Expert opinion: </strong>Imaging plays an essential role in properly diagnosing, guiding biopsy and monitoring treatment. Computed tomography (CT) is particularly helpful for evaluating bone involvement, while magnetic resonance imaging (MRI) is preferred for assessing parenchymal brain and meningeal lesions. The disease can present in either tumoral or neurodegenerative forms, manifesting with varied symptoms depending on the affected region.</p>","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"1-23"},"PeriodicalIF":3.7,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction. 修正。
IF 3.7 3区 医学
Expert Review of Clinical Immunology Pub Date : 2025-09-21 DOI: 10.1080/1744666X.2025.2563950
{"title":"Correction.","authors":"","doi":"10.1080/1744666X.2025.2563950","DOIUrl":"https://doi.org/10.1080/1744666X.2025.2563950","url":null,"abstract":"","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"1"},"PeriodicalIF":3.7,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cross-reactive IgE responses to cockroach, house dust mite, and seafood allergens in patients with allergic rhinitis. 变应性鼻炎患者对蟑螂、屋尘螨和海鲜过敏原的交叉反应性IgE反应。
IF 3.7 3区 医学
Expert Review of Clinical Immunology Pub Date : 2025-09-01 Epub Date: 2025-09-09 DOI: 10.1080/1744666X.2025.2558060
Sakinah Mohamad, V Sha Kri Eh Dam, Asma Abdullah Nurul, Fook Tim Chew, Baharudin Abdullah
{"title":"Cross-reactive IgE responses to cockroach, house dust mite, and seafood allergens in patients with allergic rhinitis.","authors":"Sakinah Mohamad, V Sha Kri Eh Dam, Asma Abdullah Nurul, Fook Tim Chew, Baharudin Abdullah","doi":"10.1080/1744666X.2025.2558060","DOIUrl":"10.1080/1744666X.2025.2558060","url":null,"abstract":"<p><strong>Background: </strong>Cockroach allergens remain underrecognized in allergic diseases, despite growing evidence of their clinical impact. This study investigated cockroach sensitization prevalence in allergic rhinitis (AR) patients and its cross-reactivity with house dust mite (HDM) and seafood allergens.</p><p><strong>Methods: </strong>110 AR patients sensitized to at least one of eight allergens: <i>Periplaneta americana</i> (PA), <i>Blattella germanica</i> (BG), <i>Dermatophagoides pteronyssinus</i> (DP), <i>Dermatophagoides farinae</i> (DF), <i>Blomia tropicalis</i> (BT), shrimp, crab and squid were enrolled. Sensitization was assessed using skin prick testing (SPT) and sIgE assays and cross-reactivity by direct and inhibition enzyme-linked immunosorbent assays (ELISA).</p><p><strong>Results: </strong>HDM allergens were the most sensitized (BT: 90%, DP: 50.9%, DF: 49.1%), followed by cockroach allergens (PA/BG: 39.1%) and seafood allergens (shrimp: 30.9%, crab: 25.5%, squid: 24.5%). sIgE testing yielded comparable results. BT demonstrated the highest prevalence. Cross-reactivity was pronounced between cockroach and HDM allergens, followed by intra-cockroach species. DP had the highest frequency of cross-reactivity among HDM allergens, while BG had a higher cross-reactivity with HDM (44.5%) than PA (40.9%). Cockroach allergens exhibited minimal cross-reactivity with seafood allergens.</p><p><strong>Conclusions: </strong>SPT and direct ELISA performed equally, demonstrating their usefulness for assessing sensitization. Cockroach allergens interact strongly with HDM but have limited cross-reactivity with seafood.</p>","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"1307-1314"},"PeriodicalIF":3.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eradicating measurable residual disease via immunotherapy to cure acute lymphoblastic leukemia: current status and future directions. 免疫治疗急性淋巴细胞白血病根除可测量的残留疾病:现状与未来方向。
IF 3.7 3区 医学
Expert Review of Clinical Immunology Pub Date : 2025-09-01 Epub Date: 2025-08-23 DOI: 10.1080/1744666X.2025.2550646
Xiao-Su Zhao, Yu-Lun Chen, Si-Qi Li, Mi Deng, Ying-Jun Chang
{"title":"Eradicating measurable residual disease via immunotherapy to cure acute lymphoblastic leukemia: current status and future directions.","authors":"Xiao-Su Zhao, Yu-Lun Chen, Si-Qi Li, Mi Deng, Ying-Jun Chang","doi":"10.1080/1744666X.2025.2550646","DOIUrl":"10.1080/1744666X.2025.2550646","url":null,"abstract":"<p><strong>Introduction: </strong>Eradicating measurable residual disease (MRD) may represent the final hurdle in curing ALL. The introduction of immunotherapies alone or in combination with other agents to therapies, including induction therapy, consolidation therapy, maintenance therapy, preemptive therapy and salvage therapy, was superior to chemotherapy alone in eradicating MRD during the course of treatment, leading to improved survival.</p><p><strong>Areas covered: </strong>We provide a concise overview of the techniques used for MRD detection. We focus on the application of immunotherapies for MRD eradication at different treatment timepoints, and the factors associated with poor outcomes in patients receiving immunotherapies. We also discuss the underlying mechanisms of immunotherapy resistance in leukemia. Additionally, we highlight the importance of characterizing residual disease and designing prospective clinical trials, as these efforts may contribute to the development of novel immunotherapies and help determine which currently available immunotherapies are most effective.</p><p><strong>Expert opinion: </strong>Immunotherapies represent a breakthrough and are currently changing the status quo of ALL therapy. Future research should focus on biomarker-directed individual immunotherapy, mechanism-driven development of new therapies, and clinical trials to identify the best immunotherapy.</p>","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"1215-1228"},"PeriodicalIF":3.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetic landscape of IL-10 in Graves' disease: site-specific DNA methylation alterations and their associations with immune dysregulation. 格雷夫斯病中IL-10的表观遗传景观:位点特异性DNA甲基化改变及其与免疫失调的关联
IF 3.7 3区 医学
Expert Review of Clinical Immunology Pub Date : 2025-09-01 Epub Date: 2025-09-02 DOI: 10.1080/1744666X.2025.2554656
Wenyu Xu, Yalin Wang, Guangxin Li, Yanping Yang, Jing Zhang, Kaidai Mu, Na Li, Jinan Zhang
{"title":"Epigenetic landscape of IL-10 in Graves' disease: site-specific DNA methylation alterations and their associations with immune dysregulation.","authors":"Wenyu Xu, Yalin Wang, Guangxin Li, Yanping Yang, Jing Zhang, Kaidai Mu, Na Li, Jinan Zhang","doi":"10.1080/1744666X.2025.2554656","DOIUrl":"10.1080/1744666X.2025.2554656","url":null,"abstract":"<p><strong>Objective: </strong>Epigenetic modifications, particularly deoxyribonucleic acid (DNA) methylation, regulate the expression of immune-mediated factors. This study aimed to investigate the methylation landscape of the interleukin-10 (IL10) gene in Graves' disease (GD).</p><p><strong>Methods: </strong>This study quantitatively profiled DNA methylation levels within the IL-10 gene using peripheral blood samples from GD patients and healthy controls. Machine learning models were constructed based on CpG methylation features to classify disease status. Furthermore, correlation between specific CpG sites methylation and clinical indicators were analyzed.</p><p><strong>Results: </strong>This study enrolled 60 patients diagnosed with GD and 51 healthy controls. Methylation analysis revealed significantly elevated methylation at multiple IL-10 CpG sites in the GD group compared to the healthy controls (<i>p</i> < 0.01), forming a hypermethylated cluster. Interestingly, the newly-diagnosed GD (NGD) group also showed higher methylation at specific sites compared to the recurrent GD (RGD) group. Correlation analysis showed that methylation at chr1_206947188_R and chr1_206947135_R were positively correlated with FT3 and TRAb levels, indicating that site-specific methylation changes were associated with disease severity and immune activity in GD.</p><p><strong>Conclusions: </strong>Our findings highlight distinct methylation patterns of the IL-10 gene in GD, with specific CpG sites carrying potential implications for disease diagnosis, stratification, and monitoring.</p>","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"1297-1305"},"PeriodicalIF":3.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-infectious pulmonary and gastrointestinal manifestations in primary antibody deficiencies: lessons for the clinic. 一抗缺乏的非感染性肺部和胃肠道表现:对临床的启示。
IF 3.7 3区 医学
Expert Review of Clinical Immunology Pub Date : 2025-09-01 Epub Date: 2025-09-18 DOI: 10.1080/1744666X.2025.2556435
Marianna Franco, Helena Buso, Francesca Carfora, Giulia Anna Maria Luigia Costanzo, Carla Felice, Marcello Rattazzi, Francesco Cinetto, Cinzia Milito, Davide Firinu
{"title":"Non-infectious pulmonary and gastrointestinal manifestations in primary antibody deficiencies: lessons for the clinic.","authors":"Marianna Franco, Helena Buso, Francesca Carfora, Giulia Anna Maria Luigia Costanzo, Carla Felice, Marcello Rattazzi, Francesco Cinetto, Cinzia Milito, Davide Firinu","doi":"10.1080/1744666X.2025.2556435","DOIUrl":"10.1080/1744666X.2025.2556435","url":null,"abstract":"<p><strong>Introduction: </strong>Primary antibody deficiencies (PADs), especially common variable immunodeficiency (CVID), are clinically significant inborn errors of immunity due to complex phenotypes and long-term complications. This review provides an updated overview of pulmonary and gastrointestinal manifestations in PADs, focusing on CVID.</p><p><strong>Areas covered: </strong>We conducted a structured literature review of original articles, reviews, and guidelines from the last 10 years, using databases such as PubMed and Scopus. The focus was on immunopathogenesis, clinical features, and treatment of noninfectious pulmonary and gastrointestinal complications in CVID. Key shared immunological pathways include B- and T-cell dysregulation, cytokine-driven inflammation, and microbiota alterations.</p><p><strong>Expert opinion: </strong>Early recognition of noninfectious complications in CVID is vital to prevent organ damage and improve outcomes. A multidisciplinary, personalized approach involving genetic, immunologic, and microbiologic assessments and specialists including pathologists, pulmonologists, and gastroenterologists is essential, considering the pulmonary-gastrointestinal axis's role in mucosal immune dysfunction and systemic immune dysregulation.</p>","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"1229-1249"},"PeriodicalIF":3.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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