Genetic polymorphisms and cytokine levels in ischemic stroke: associations with subtypes and prognosis.

IF 3.9 3区 医学 Q2 IMMUNOLOGY
Gaetano Pacinella, Anna Maria Ciaccio, Alessandra Casuccio, Mario Daidone, Rosaria Pecoraro, Danilo Di Bona, Alessandro Del Cuore, Maria Grazia Puleo, Domenico Di Raimondo, Tiziana Di Chiara, Giuseppe Miceli, Vittoriano Della Corte, Valentina Arnao, Antonino Tuttolomondo
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Abstract

Introduction: Some genetic polymorphisms are associated with the risk of stroke, although the individual contribution of such polymorphisms is considered modest.

Aims: To evaluate the frequency of single nucleotide polymorphisms (SNPs) in genes encoding proinflammatory cytokines and coagulation factors in stroke patients, the relationships between the serum levels of the cytokines analyzed with stroke subtypes and prognosis.

Material and methods: A retrospective, cross-sectional, observational, analytical, case-control study. We performed genetic analysis to evaluate various genetic polymorphisms and analyzed cytokine levels at admission.

Results: 429 patients with ischemic stroke and 195 control subjects without ischemic stroke. Patients with CEI subtype showed significantly higher levels of all the cytokines analyzed, namely, IL-10, TNF-alpha, and IL-6. Logistic regression analysis revealed that higher TNF-α (alpha), IL-6, and IL-1 β levels were significantly associated with the LAAS and CEI subtypes. TNF-α, IL-1, and IL-6 levels were significantly higher in patients with recurrent stroke at follow-up.Of the three polymorphisms in the gene encoding PTSG2, the haplotypes rs6275 and rs20417 showed a different distribution between patients and controls.

Discussion: The reported association between ischemic stroke and immunoinflammatory variables agrees with previously reported associations between some proinflammatory and prothrombotic polymorphisms and the risk of ischemic stroke.

缺血性卒中的遗传多态性和细胞因子水平:与亚型和预后的关系。
一些遗传多态性与中风风险相关,尽管这种多态性的个体贡献被认为是适度的。目的:探讨脑卒中患者促炎因子和凝血因子编码基因的单核苷酸多态性(snp)频率,分析血清细胞因子水平与脑卒中亚型及预后的关系。材料和方法:回顾性、横断面、观察性、分析性、病例对照研究。我们进行了遗传分析来评估各种遗传多态性,并分析了入院时的细胞因子水平。结果:缺血性脑卒中患者429例,非缺血性脑卒中对照195例。CEI亚型患者的所有细胞因子水平均显著升高,即IL-10、tnf - α和IL-6。Logistic回归分析显示,较高的TNF-α (α)、IL-6和IL-1 β水平与LAAS和CEI亚型显著相关。随访时复发性脑卒中患者TNF-α、IL-1、IL-6水平明显升高。在编码PTSG2基因的3个多态性中,单倍型rs6275和rs20417在患者和对照组之间表现出不同的分布。讨论:报道的缺血性卒中和免疫炎症变量之间的关联与先前报道的一些促炎和血栓形成前多态性与缺血性卒中风险之间的关联一致。
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来源期刊
CiteScore
7.60
自引率
2.30%
发文量
221
审稿时长
6-12 weeks
期刊介绍: Expert Review of Clinical Immunology (ISSN 1744-666X) provides expert analysis and commentary regarding the performance of new therapeutic and diagnostic modalities in clinical immunology. Members of the International Editorial Advisory Panel of Expert Review of Clinical Immunology are the forefront of their area of expertise. This panel works with our dedicated editorial team to identify the most important and topical review themes and the corresponding expert(s) most appropriate to provide commentary and analysis. All articles are subject to rigorous peer-review, and the finished reviews provide an essential contribution to decision-making in clinical immunology. Articles focus on the following key areas: • Therapeutic overviews of specific immunologic disorders highlighting optimal therapy and prospects for new medicines • Performance and benefits of newly approved therapeutic agents • New diagnostic approaches • Screening and patient stratification • Pharmacoeconomic studies • New therapeutic indications for existing therapies • Adverse effects, occurrence and reduction • Prospects for medicines in late-stage trials approaching regulatory approval • Novel treatment strategies • Epidemiological studies • Commentary and comparison of treatment guidelines Topics include infection and immunity, inflammation, host defense mechanisms, congenital and acquired immunodeficiencies, anaphylaxis and allergy, systemic immune diseases, organ-specific inflammatory diseases, transplantation immunology, endocrinology and diabetes, cancer immunology, neuroimmunology and hematological diseases.
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