Expert Review of Clinical Immunology最新文献

Real-life preliminary evidence for Basophils as predictors of tezepelumab response in severe asthma. 嗜碱性粒细胞作为严重哮喘患者tezepelumab反应预测因子的现实初步证据。

IF 3.9 3区医学

Expert Review of Clinical Immunology Pub Date : 2025-06-05 DOI: 10.1080/1744666X.2025.2517157

Vitaliano Nicola Quaranta, Andrea Portacci, Ernesto Lulaj, Silvano Dragonieri, Santina Ferrulli, Flogerta Sana, Enrico Buonamico, Emanuela Resta, Giovanna Elisiana Carpagnano

{"title":"Real-life preliminary evidence for Basophils as predictors of tezepelumab response in severe asthma.","authors":"Vitaliano Nicola Quaranta, Andrea Portacci, Ernesto Lulaj, Silvano Dragonieri, Santina Ferrulli, Flogerta Sana, Enrico Buonamico, Emanuela Resta, Giovanna Elisiana Carpagnano","doi":"10.1080/1744666X.2025.2517157","DOIUrl":"https://doi.org/10.1080/1744666X.2025.2517157","url":null,"abstract":"Background: Severe asthma is a complex disease with persistent symptoms despite high-dose inhaled therapy. Tezepelumab, a monoclonal antibody targeting thymic stromal lymphopoietin (TSLP), has shown efficacy across asthma phenotypes. However, identifying early responders remains a challenge. Basophils, key players in type 2 inflammation, may serve as predictive biomarkers.Objective: We evaluated the presence of super-responder status after six months of Tezepelumab therapy and explored the predictive role of blood basophil levels.Methods: A real-life, prospective study was conducted on 16 severe asthma patients. Super-responders were defined per Upham et al.'s criteria, adapted for a six-month assessment. Clinical, functional, and inflammatory parameters, including blood basophil counts, were analyzed.Results: After six months, 62.5% of patients achieved super-responder status, with complete exacerbation elimination, reduced oral corticosteroid use, and improved asthma control. A significant logarithmic association (p = 0.019) was found between baseline basophil levels and super-responder status, indicating that higher basophil counts were associated with an increased likelihood of super-response. This finding was supported by a trend toward significance in ROC curve analysis (AUC = 0.800, p = 0.050), suggesting potential predictive value.Conclusion: Tezepelumab demonstrates early efficacy in severe asthma, and baseline blood basophil levels may represent a promising biomarker for response prediction.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic polymorphisms and cytokine levels in ischemic stroke: associations with subtypes and prognosis. 缺血性卒中的遗传多态性和细胞因子水平：与亚型和预后的关系。

IF 3.9 3区医学

Expert Review of Clinical Immunology Pub Date : 2025-06-05 DOI: 10.1080/1744666X.2025.2517164

Gaetano Pacinella, Anna Maria Ciaccio, Alessandra Casuccio, Mario Daidone, Rosaria Pecoraro, Danilo Di Bona, Alessandro Del Cuore, Maria Grazia Puleo, Domenico Di Raimondo, Tiziana Di Chiara, Giuseppe Miceli, Vittoriano Della Corte, Valentina Arnao, Antonino Tuttolomondo

{"title":"Genetic polymorphisms and cytokine levels in ischemic stroke: associations with subtypes and prognosis.","authors":"Gaetano Pacinella, Anna Maria Ciaccio, Alessandra Casuccio, Mario Daidone, Rosaria Pecoraro, Danilo Di Bona, Alessandro Del Cuore, Maria Grazia Puleo, Domenico Di Raimondo, Tiziana Di Chiara, Giuseppe Miceli, Vittoriano Della Corte, Valentina Arnao, Antonino Tuttolomondo","doi":"10.1080/1744666X.2025.2517164","DOIUrl":"https://doi.org/10.1080/1744666X.2025.2517164","url":null,"abstract":"Introduction: Some genetic polymorphisms are associated with the risk of stroke, although the individual contribution of such polymorphisms is considered modest.Aims: To evaluate the frequency of single nucleotide polymorphisms (SNPs) in genes encoding proinflammatory cytokines and coagulation factors in stroke patients, the relationships between the serum levels of the cytokines analyzed with stroke subtypes and prognosis.Material and methods: A retrospective, cross-sectional, observational, analytical, case-control study. We performed genetic analysis to evaluate various genetic polymorphisms and analyzed cytokine levels at admission.Results: 429 patients with ischemic stroke and 195 control subjects without ischemic stroke. Patients with CEI subtype showed significantly higher levels of all the cytokines analyzed, namely, IL-10, TNF-alpha, and IL-6. Logistic regression analysis revealed that higher TNF-α (alpha), IL-6, and IL-1 β levels were significantly associated with the LAAS and CEI subtypes. TNF-α, IL-1, and IL-6 levels were significantly higher in patients with recurrent stroke at follow-up.Of the three polymorphisms in the gene encoding PTSG2, the haplotypes rs6275 and rs20417 showed a different distribution between patients and controls.Discussion: The reported association between ischemic stroke and immunoinflammatory variables agrees with previously reported associations between some proinflammatory and prothrombotic polymorphisms and the risk of ischemic stroke.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms and therapeutic potential of epithelial-immune crosstalk in airway inflammation. 气道炎症中上皮免疫串扰的机制和治疗潜力。

IF 3.9 3区医学

Expert Review of Clinical Immunology Pub Date : 2025-06-04 DOI: 10.1080/1744666X.2025.2514604

Ying Chen, Yujuan Yang, Huifang Liu, Yan Hao, Xinjun Xu, Yu Zhang, Hongfei Zhao, Ting Zuo, Hang Yu, Jiali Yin, Xicheng Song

{"title":"Mechanisms and therapeutic potential of epithelial-immune crosstalk in airway inflammation.","authors":"Ying Chen, Yujuan Yang, Huifang Liu, Yan Hao, Xinjun Xu, Yu Zhang, Hongfei Zhao, Ting Zuo, Hang Yu, Jiali Yin, Xicheng Song","doi":"10.1080/1744666X.2025.2514604","DOIUrl":"10.1080/1744666X.2025.2514604","url":null,"abstract":"Introduction: Chronic airway inflammatory diseases mainly comprise chronic rhinosinusitis (CRS), allergic rhinitis (AR), asthma, cystic fibrosis (CF), and chronic obstructive pulmonary disease (COPD). Epithelial cells fulfill a protective role as a barrier; however, when stimulated, these cells also release a variety of cytokines that attract and activate immune cells, including macrophages, neutrophils, and T-lymphocytes. Excessive activation and aggregation of immune cells disrupts the balance of the cellular microenvironment, and leads to impaired immune defense of the airway mucosa, which can further exacerbate an inflammatory response.Areas covered: In this article, we discuss the key cytokines and immune pathways involved in epithelial-immune cell interactions, and we detail discoveries in the emerging field of single-cell sequencing and summarize monoclonal antibody-targeted therapies. A comprehensive search was conducted using the search terms 'epithelial cell,' 'immune,' 'interaction,' 'cytokines,' 'asthma,' 'chronic sinusitis,' 'allergic rhinitis,' 'monoclonal antibodies,' and 'single-cell sequencing' by querying Google Scholar and PubMed.Expert opinion: The intricate pathophysiology of airway inflammation remains to be fully elucidated. Emerging technologies, such as single-cell sequencing, have led to a more comprehensive characterization of the immune mechanisms underlying the pathophysiology of airway inflammatory diseases, which points the way to further precision medicine in the future.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"1-15"},"PeriodicalIF":3.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dysautonomia in systemic lupus erythematosus: when to suspect and how to investigate. 系统性红斑狼疮的自主神经异常：何时怀疑及如何调查。

IF 3.9 3区医学

Expert Review of Clinical Immunology Pub Date : 2025-06-04 DOI: 10.1080/1744666X.2025.2511265

Caio Francisco C Frazatto, Alberto Rolim Muro Martinez, Simone Appenzeller

{"title":"Dysautonomia in systemic lupus erythematosus: when to suspect and how to investigate.","authors":"Caio Francisco C Frazatto, Alberto Rolim Muro Martinez, Simone Appenzeller","doi":"10.1080/1744666X.2025.2511265","DOIUrl":"https://doi.org/10.1080/1744666X.2025.2511265","url":null,"abstract":"Introduction: Among the neuropsychiatric manifestations of Systemic lupus erythematosus (SLE), there are manifestations related to the peripheral nervous system (PNS). The autonomic nervous system, a subdivision of the PNS, is poorly studied in patients with SLE, and most often not recognized in clinical practice. However, it's possible that autonomic impairment is more common than we thought and many manifestations without a clear pathophysiology may be explained by autonomic impairment.Areas covered: This review is based on selected articles from the PUBMED database that evaluated autonomic dysfunction in SLE. Also explored some common symptoms in SLE without a clearly explanation, that can be due to autonomic impairment. Finally we proposed a clinical approach to autonomic evaluation in SLE.Expert opinion: A wide range of clinical manifestations in SLE can be attributed to autonomic dysfunction, therefore it is important to search for this diagnosis to correctly treat patients and promote a better quality of life. The long-term impact of autonomic impairment is unknown and yet there is no biomarker that can help in the diagnosis.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psoriasis, pregnancy, and lactation: clinical implications and treatments. 牛皮癣，妊娠和哺乳期：临床意义和治疗。

IF 3.9 3区医学

Expert Review of Clinical Immunology Pub Date : 2025-06-02 DOI: 10.1080/1744666X.2025.2514606

Michela D'Agostino, Luca Potestio, Matteo Megna

引用次数: 0

The interplay between asthma and type 2 diabetes mellitus: mutual interactions and therapeutic implications. 哮喘和2型糖尿病的相互作用：相互作用和治疗意义。

IF 3.9 3区医学

Expert Review of Clinical Immunology Pub Date : 2025-06-01 DOI: 10.1080/1744666X.2025.2514607

Mario Cazzola, Nicola A Hanania, Clive P Page, Luigino Calzetta, Maria Gabriella Matera, Paola Rogliani

{"title":"The interplay between asthma and type 2 diabetes mellitus: mutual interactions and therapeutic implications.","authors":"Mario Cazzola, Nicola A Hanania, Clive P Page, Luigino Calzetta, Maria Gabriella Matera, Paola Rogliani","doi":"10.1080/1744666X.2025.2514607","DOIUrl":"https://doi.org/10.1080/1744666X.2025.2514607","url":null,"abstract":"Introduction: Asthma and type 2 diabetes mellitus (T2DM) are chronic diseases with a significant global health burden. Recent studies have highlighted the complex relationship between these two diseases, particularly regarding their pharmacological management.Areas covered: This review discusses the mechanisms linking asthma and T2DM and the interactions between asthma and T2DM therapies, highlighting the potential clinical implications. We examine the effects of asthma medications on glycemic control and diabetes management and review the effects of commonly used T2DM medications on outcomes in patients with asthma.Expert opinion: The effective management of asthma and T2DM requires a comprehensive appreciation of the beneficial and adverse pharmacological effects of drugs used in the treatment of asthma on glucose metabolism. It is also essential to consider the potential benefits of diabetes treatments on respiratory health and the impact of obesity on both diseases. Such knowledge can facilitate the optimization of drug plans and the minimization of adverse effects, while exploiting potential synergies between treatments for these diseases. However, to improve understanding of the complex mechanisms underlying the interaction between these chronic diseases, further research using a comprehensive approach that includes inflammatory pathways, metabolic factors, therapeutic interventions, gender differences, and lifestyle influences is needed.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vascular endothelial dysfunction in pediatric rheumatic diseases: a systematic review and meta-analysis. 儿童风湿病的血管内皮功能障碍：系统回顾和荟萃分析。

IF 3.9 3区医学

Expert Review of Clinical Immunology Pub Date : 2025-05-31 DOI: 10.1080/1744666X.2025.2510490

Marieta P Theodorakopoulou, Vasiliki Sgouropoulou, Fotini Iatridi, Artemios G Karagiannidis, Antonios Karpetas, Erasmia Sampani, Panagiota Anyfanti, Theodoros Dimitroulas, Pantelis Sarafidis

{"title":"Vascular endothelial dysfunction in pediatric rheumatic diseases: a systematic review and meta-analysis.","authors":"Marieta P Theodorakopoulou, Vasiliki Sgouropoulou, Fotini Iatridi, Artemios G Karagiannidis, Antonios Karpetas, Erasmia Sampani, Panagiota Anyfanti, Theodoros Dimitroulas, Pantelis Sarafidis","doi":"10.1080/1744666X.2025.2510490","DOIUrl":"10.1080/1744666X.2025.2510490","url":null,"abstract":"Objectives: Endothelial dysfunction is associated with increased cardiovascular risk in individuals with autoimmune diseases. This systematic review and meta-analysis included studies assessing endothelial function with functional methods in children with rheumatic diseases versus controls.Methods: Literature search involved PubMed and Scopus databases (from inception to February 2024) and manual reference screening. Studies assessing endothelial function by all available functional methods were eligible. Study quality was evaluated via Newcastle-Ottawa scale.Results: Twenty-four studies (880 children with rheumatic diseases, 784 controls) were included in meta-analysis. Pooled analysis showed significantly impaired endothelial function in patients versus controls (SMD: -0.74, 95%CI -1.10 to -0.39) but with high heterogeneity (I2 = 91%, p < 0.001); sensitivity analysis including only high-quality studies confirmed this finding (SMD: -0.83, 95%CI -1.20 to -0.46). In subgroup analyses according to type of rheumatic disease, significantly impaired endothelial function was showed for patients with juvenile idiopathic arthritis (SMD: -1.05, 95%CI -1.84 to -0.25), vasculitis (SMD: -0.74, 95%CI -1.11 to -0.37) and juvenile systemic sclerosis (SMD -2.48, 95%CI -4.34 to -0.61).Conclusions: Children with rheumatic diseases show impaired endothelial function. Future studies are needed to elucidate whether endothelial dysfunction is involved in high cardiovascular risk of these patients.Prospero registration number: CRD42023413799.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"1-11"},"PeriodicalIF":3.9,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic dysfunction-associated steatotic liver disease in inflammatory bowel disease: prevalence, risk factors, pathophysiological pathways and clinical consequences. 炎症性肠病中代谢功能障碍相关的脂肪变性肝病：患病率、危险因素、病理生理途径和临床后果

IF 3.9 3区医学

Expert Review of Clinical Immunology Pub Date : 2025-05-30 DOI: 10.1080/1744666X.2025.2514605

Elena Grueso Navarro, Alfredo J Lucendo

{"title":"Metabolic dysfunction-associated steatotic liver disease in inflammatory bowel disease: prevalence, risk factors, pathophysiological pathways and clinical consequences.","authors":"Elena Grueso Navarro, Alfredo J Lucendo","doi":"10.1080/1744666X.2025.2514605","DOIUrl":"https://doi.org/10.1080/1744666X.2025.2514605","url":null,"abstract":"Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common liver comorbidity in patients with inflammatory bowel disease (IBD).Areas covered: This paper outlines common pathophysiological aspects related to MASLD and IBD; describes the epidemiological clues associated with both diseases; analyzes risk factors contributing to MASLD appearance and progression in IBD patients; reviews data on clinical consequences for this population; and provides advice on the management of patients with both conditions.Expert opinion: IBD itself, especially Crohns' disease, is a risk factor for MASLD and its progression to liver cirrhosis, independent of other cardiometabolic risk factors. Intestine-dependent mechanisms which contribute to MASLD in IBD and interplay with classic metabolic factors include sarcopenia, disease phenotype, duration and activity. Changes in microbiota also contribute to deregulating the gut-liver-axis in these conditions. By contrast, IBD therapies do not seem to play a relevant role in the risk of developing MASLD; and the potential of biologics and novel small molecules on liver changes requires further investigation. MASLD increases comorbidities, impairs clinical outcomes and increases mortality in IBD patients; therefore, early detection of MASLD is a priority in IBD populations. Individualized and integrative management of both MASLD and IBD is required to improve results.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation of serum Helios, CD226, tigit, and Foxp3 with tear film osmotic pressure and dry eye disease in patients with rheumatoid arthritis. 类风湿性关节炎患者血清Helios、CD226、tigit和Foxp3与泪膜渗透压和干眼症的相关性

IF 3.9 3区医学

Expert Review of Clinical Immunology Pub Date : 2025-05-29 DOI: 10.1080/1744666X.2025.2512451

Lijing Huang, Peilin Cheng, Zheli Niu, Liping Zang, Zicong Chen, Chunchun Yang, Wenhua Ma, Wenjia Nie

{"title":"Correlation of serum Helios, CD226, tigit, and Foxp3 with tear film osmotic pressure and dry eye disease in patients with rheumatoid arthritis.","authors":"Lijing Huang, Peilin Cheng, Zheli Niu, Liping Zang, Zicong Chen, Chunchun Yang, Wenhua Ma, Wenjia Nie","doi":"10.1080/1744666X.2025.2512451","DOIUrl":"https://doi.org/10.1080/1744666X.2025.2512451","url":null,"abstract":"Objective: This study investigated the correlation between serum Helios, CD226, TIGIT, and Foxp3 levels and tear film osmotic pressure in individuals with rheumatoid arthritis (RA) and dry eye disease.Methods: This case-control study enrolled 100 RA patients with dry eye and 100 healthy controls from May 2021 to June 2022. mRNA expression of target genes was quantified using quantitative real-time PCR (qRT-PCR). Tear film osmolality was measured with a commercial osmometer. Statistical analyses included Pearson correlation and multivariate logistic regression.Results: Compared with controls, RA patients exhibited significantly higher mRNA levels of Helios, CD226, TIGIT, and Foxp3 (P<0.05), along with elevated mean tear osmolarity (312.5±12.3 vs. 295.4±10.8 milliosmoles per liter (mOsm/L), P<0.05). Notably, 68% of RA patients exceeded the 308 mOsm/L diagnostic threshold versus 22% controls (P<0.05). Helios (r=0.62) and Foxp3 (r=0.58) correlated positively with osmotic pressure, while TIGIT showed a negative correlation (r=-0.49, P<0.05). Logistic regression revealed that elevated levels of Helios (OR=2.1, 95% CI: 1.4-3.2), CD226 (OR=1.8, 95% CI: 1.2-2.7), and Foxp3 (OR=1.9, 95% CI: 1.3-2.8) were associated with increased dry eye risk (P<0.05).Conclusion: These immune markers demonstrate significant associations with tear film instability in RA, serving as potential biomarkers for ocular comorbidity monitoring.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential future biologic therapies for the treatment of vitiligo: focus on phase 2 and 3. 未来治疗白癜风的潜在靶向疗法：重点是2期和3期。

IF 3.9 3区医学

Expert Review of Clinical Immunology Pub Date : 2025-05-27 DOI: 10.1080/1744666X.2025.2512452

Vincenzo Picone, Luigi Coronella, Massimiliano Scalvenzi, Cataldo Patruno, Ludovica Lizzi, Marianna Cimmino, Maddalena Napolitano

{"title":"Potential future biologic therapies for the treatment of vitiligo: focus on phase 2 and 3.","authors":"Vincenzo Picone, Luigi Coronella, Massimiliano Scalvenzi, Cataldo Patruno, Ludovica Lizzi, Marianna Cimmino, Maddalena Napolitano","doi":"10.1080/1744666X.2025.2512452","DOIUrl":"10.1080/1744666X.2025.2512452","url":null,"abstract":"Introduction: Vitiligo is a chronic autoimmune skin disorder characterized by the loss of melanocytes, leading to depigmented patches on the skin and mucous membranes. Its increasing prevalence and impact on patients' quality of life highlight the need for updated therapeutic strategies.Areas covered: This review discusses recent advances in the understanding of vitiligo pathogenesis, focusing on genetic predisposition, environmental triggers, and immune dysregulation-particularly the role of autoreactive CD8+ T cells and inflammatory cytokines such as IFN-γ. The literature search included recent clinical trials and emerging therapies. Novel approaches, including JAK inhibitors (e.g. povorcitinib, upadacitinib) and monoclonal antibodies (e.g. anifrolumab), are evaluated for their efficacy and safety based on phase II and III clinical trial data.Expert opinion: Targeted therapies that address immune mechanisms and oxidative stress represent promising advances in vitiligo management and may substantially improve patient outcomes in the near future.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"1-11"},"PeriodicalIF":3.9,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0