Expert Review of Clinical Immunology最新文献

Diagnostic accuracy of QuantiFERON-TB Gold Plus with Chemiluminescence Immunoassay: a systematic review and meta-analysis QuantiFERON-TB Gold Plus化学发光免疫测定的诊断准确性：系统综述和荟萃分析

IF 4.4 3区医学

Expert Review of Clinical Immunology Pub Date : 2024-09-19 DOI: 10.1080/1744666x.2024.2407550

Shima Mahmoudi, Seyed Mohammad Sajad Hosseini Sharif

引用次数: 0

Complement as a major mediator of ANCA vasculitis and a target for precision therapy 补体是 ANCA 血管炎的主要介质和精准治疗的靶点

IF 4.4 3区医学

Expert Review of Clinical Immunology Pub Date : 2024-09-18 DOI: 10.1080/1744666x.2024.2405170

Donna O. Bunch, Sarah E. Lewis, Hong Xiao, Peiqi Hu, J. Charles Jennette, Eveline Y. Wu

引用次数: 0

Innovative cell therapies for systemic sclerosis: available evidence and new perspectives 治疗系统性硬化症的创新细胞疗法：现有证据和新视角

IF 4.4 3区医学

Expert Review of Clinical Immunology Pub Date : 2024-09-16 DOI: 10.1080/1744666x.2024.2402494

Alain Lescoat, Monalisa Ghosh, Stephan Kadauke, Dinesh Khanna

引用次数: 0

Nociplastic pain in axial spondyloarthritis and psoriatic arthritis: role of JAK kinases in immunopathology and therapeutic impact of JAK inhibitors. 轴性脊柱关节炎和银屑病关节炎中的非关节痛：JAK 激酶在免疫病理学中的作用以及 JAK 抑制剂的治疗效果。

IF 3.9 3区医学

Expert Review of Clinical Immunology Pub Date : 2024-09-08 DOI: 10.1080/1744666X.2024.2400294

Natalya Horbal, Walter P Maksymowych

{"title":"Nociplastic pain in axial spondyloarthritis and psoriatic arthritis: role of JAK kinases in immunopathology and therapeutic impact of JAK inhibitors.","authors":"Natalya Horbal, Walter P Maksymowych","doi":"10.1080/1744666X.2024.2400294","DOIUrl":"10.1080/1744666X.2024.2400294","url":null,"abstract":"Introduction: Pain in both peripheral and axial joints is a major symptom in patients with psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA). Emerging evidence demonstrates pain mechanisms, beyond those related to inflammation or joint damage, based on aberrant processing of nociceptive stimuli peripherally as well as centrally. The Janus kinase/signal transducers and activators of transcription (JAK-STAT) signaling pathway has been implicated in the processing of pain beyond its role in mediating inflammation and inhibitors of this pathway approved for the treatment of axSpA and PsA have been shown to alleviate a broad array of pain outcomes in both axial and peripheral joints.Areas covered: We review recent definitions and standardization of the nomenclature for categorizing chronic pain according to causality, assessment tools to evaluate nociplastic pain, the pathophysiologic role of JAK-STAT signaling in nociplastic pain, evidence for the presence of nociplastic pain in axSpA and PsA, and the impact of JAK inhibitors (JAKi) on pain outcomes in clinical trials (PubMed: 01/01/2019-04/01-2024).Expert opinion: Nociplastic pain assessment has been confined almost entirely to the use of a limited number of questionnaires in cross-sectional studies of these diseases. Though effective for alleviating pain, it is unclear if JAKi specifically impact nociplastic pain.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolation and analysis of the exosomal membrane proteins in bullous pemphigoid. 牛皮癣外泌体膜蛋白的分离与分析。

IF 3.9 3区医学

Expert Review of Clinical Immunology Pub Date : 2024-09-04 DOI: 10.1080/1744666X.2024.2396155

Yangchun Liu, Jialing Zhang, Bingjie Zhang, Xuming Mao, Yiman Wang, Yanhong Wang, Meng Fan, Xuan Liu, Jin An, Hongzhong Jin, Li Li

{"title":"Isolation and analysis of the exosomal membrane proteins in bullous pemphigoid.","authors":"Yangchun Liu, Jialing Zhang, Bingjie Zhang, Xuming Mao, Yiman Wang, Yanhong Wang, Meng Fan, Xuan Liu, Jin An, Hongzhong Jin, Li Li","doi":"10.1080/1744666X.2024.2396155","DOIUrl":"https://doi.org/10.1080/1744666X.2024.2396155","url":null,"abstract":"Background: Bullous pemphigoid (BP) is a severe autoimmune sub-epidermal bullous disease. Exosomes are small extracellular vesicles secreted by most cell types. The exosomal membrane proteins are implicated in various biological and pathological pathways. This study aims to explore the potential roles of exosomes in BP pathomechanism.Research design: We collected plasma samples from 30 BP patients and 31 healthy controls. Nanoparticle tracking analysis (NTA) was used to analyze the size and concentration of exosomes. The immunogold labelling experiment and extracellular vesicle (EV) array were performed to detect the content and distribution of exosomes.Results: The exosomes from both the BP and control groups' plasma were successfully extracted. EV Array showed that CD63 and CD9 levels were significantly higher in the BP group than in the control group (p < 0.05). Expression levels of the BP180 NC16A and intracellular domain (ICD) were higher in the anti-BP180 positive group versus the controls (p < 0.05). The active BP group exhibits higher CD63 and BP180 ICD protein concentrations than the control or inactive BP groups (p < 0.05).Conclusion: BP180 autoantigen fragments were expressed on the exosomal membrane in BP patients. The BP180 ICD and CD63 on exosomes could potentially be novel biomarkers for monitoring disease activity.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive value analysis of albumin-related inflammatory markers for short-term outcomes in patients with In-hospital cardiac arrest. 白蛋白相关炎症指标对院内心脏骤停患者短期预后的预测价值分析。

IF 3.9 3区医学

Expert Review of Clinical Immunology Pub Date : 2024-09-04 DOI: 10.1080/1744666X.2024.2399700

Linlin Xiao, Feng Li, Yuanhui Sheng, Xueping Hou, Xixi Liao, Pengfei Zhou, Yuping Qin, Xiaoying Chen, Jinglun Liu, Yetao Luo, Dong Peng, Shan Xu, Dan Zhang

{"title":"Predictive value analysis of albumin-related inflammatory markers for short-term outcomes in patients with In-hospital cardiac arrest.","authors":"Linlin Xiao, Feng Li, Yuanhui Sheng, Xueping Hou, Xixi Liao, Pengfei Zhou, Yuping Qin, Xiaoying Chen, Jinglun Liu, Yetao Luo, Dong Peng, Shan Xu, Dan Zhang","doi":"10.1080/1744666X.2024.2399700","DOIUrl":"10.1080/1744666X.2024.2399700","url":null,"abstract":"Objective: This study investigated the predictive value of albumin-related inflammatory markers for short-term outcomes in in-hospital cardiac arrest (IHCA) patients.Methods: A linear mixed model investigated the dynamic changes of markers within 72 hours after return of spontaneous circulation (ROSC). Time-Dependent COX regression explored the predictive value. Mediation analysis quantified the association of markers with organ dysfunctions and adverse outcomes.Results: Prognostic Nutritional Index (PNI) and RDW-Albumin Ratio (RAR) slightly changed (p > 0.05). Procalcitonin-Albumin Ratio (PAR1) initially increased and then slowly decreased. Neutrophil-Albumin Ratio (NAR) and Platelet-Albumin Ratio (PAR2) decreased slightly during 24-48 hours (all p<0.05). PNI (HR = 1.646, 95%CI (1.033,2.623)), PAR1 (HR = 1.69, 95%CI (1.057,2.701)), RAR (HR = 1.752,95%CI (1.103,2.783)) and NAR (HR = 1.724,95%CI (1.078,2.759)) were independently associated with in-hospital mortality. PNI (PM = 45.64%, 95%CI (17.05%,87.02%)), RAR (PM = 45.07%,95%CI (14.59%,93.70%)) and NAR (PM = 46.23%,95%CI (14.59%,93.70%)) indirectly influenced in-hospital mortality by increasing SOFA (central) scores. PNI (PM = 21.75%, 95%CI(0.67%,67.75%)) may also indirectly influenced outcome by increasing SOFA (renal) scores (all p < 0.05).Conclusions: Within 72 hours after ROSC, albumin-related inflammatory markers (PNI, PAR1, RAR, and NAR) were identified as potential predictors of short-term prognosis in IHCA patients. They may mediate the adverse outcomes of patients by causing damages to the central nervous system and renal function.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cross-talk between immune cells and tumor cells in non-Hodgkin lymphomas arising in common variable immunodeficiency. 常见变异性免疫缺陷症患者非霍奇金淋巴瘤中免疫细胞与肿瘤细胞之间的交叉对话。

IF 3.9 3区医学

Expert Review of Clinical Immunology Pub Date : 2024-09-04 DOI: 10.1080/1744666X.2024.2398546

Saniya Sharma, Taru Goyal, Sanchi Chawla, Pallavi L Nadig, Arjun Bhodiakhera, Ankur Kumar Jindal, Rakesh Kumar Pilania, Manpreet Dhaliwal, Amit Rawat, Surjit Singh

{"title":"Cross-talk between immune cells and tumor cells in non-Hodgkin lymphomas arising in common variable immunodeficiency.","authors":"Saniya Sharma, Taru Goyal, Sanchi Chawla, Pallavi L Nadig, Arjun Bhodiakhera, Ankur Kumar Jindal, Rakesh Kumar Pilania, Manpreet Dhaliwal, Amit Rawat, Surjit Singh","doi":"10.1080/1744666X.2024.2398546","DOIUrl":"10.1080/1744666X.2024.2398546","url":null,"abstract":"Introduction: CVID is the commonest and most symptomatic primary immune deficiency of adulthood. NHLs are the most prevalent malignancies in CVID. The cross-talk between tumor cells and immune cells may be an important risk factor in lymphomagenesis.Areas covered: The present review highlights immune cell, genetic and histopathological alterations in the CVID-associated NHLs.Expert opinion: CVID patients exhibit some notable immune defects that may predispose to lymphomas. T/NK cell defects including reduced T cells, naïve CD4+T cells, T regs, and Th17 cells, increased CD8+T cells with reduced T cell proliferative and cytokine responses and reduced iNKT and NK cell count and cytotoxicity. B cell defects include increased transitional and CD21low B cells, clonal IgH gene rearrangements, and increased BCMA levels. Increase in IL-9, sCD30 levels, and upregulation of BAFF-BAFFR signaling are associated with lymphomas in CVID. Increased expression of PFTK1, duplication of ORC4L, germline defects in TACI, NFKB1, and PIK3CD, and somatic mutations in NOTCH2 and MYD88 are reported in CVID-associated lymphomas. Upregulation of PD-L1-PD-1 pathway may also promote lymphomagenesis in CVID. These abnormalities need to be explored as prognostic or predictive markers of CVID-associated NHLs by large multicentric studies.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-cell RNA sequencing: an emerging tool revealing dysregulated innate and adaptive immune response at single cell level in kawasaki disease. 单细胞 RNA 测序：揭示川崎病单细胞水平先天和适应性免疫反应失调的新兴工具。

IF 3.9 3区医学

Expert Review of Clinical Immunology Pub Date : 2024-09-04 DOI: 10.1080/1744666X.2024.2401105

Saniya Sharma, Sumit Goel, Taru Goyal, Rakesh Kumar Pilania, Ridhima Aggarwal, Taranpreet Kaur, Manpreet Dhaliwal, Amit Rawat, Surjit Singh

{"title":"Single-cell RNA sequencing: an emerging tool revealing dysregulated innate and adaptive immune response at single cell level in kawasaki disease.","authors":"Saniya Sharma, Sumit Goel, Taru Goyal, Rakesh Kumar Pilania, Ridhima Aggarwal, Taranpreet Kaur, Manpreet Dhaliwal, Amit Rawat, Surjit Singh","doi":"10.1080/1744666X.2024.2401105","DOIUrl":"https://doi.org/10.1080/1744666X.2024.2401105","url":null,"abstract":"Introduction: Kawasaki disease [KD] is a systemic disorder characterized by acute febrile illness due to widespread medium-vessel vasculitis, mainly affecting children. Despite the ongoing advanced research into the disease pathophysiology and molecular mechanisms, the exact etiopathogenesis of KD is still an enigma. Recently, single-cell RNA sequencing [scRNA-seq], has been utilized to elucidate the pathophysiology of KD at a resolution higher than that of previous methods.Area covered: In the present article, we re-emphasize the pivotal role of this high-resolution technique, scRNA-seq, in the characterization of immune cell transcriptomic profile and signaling/response pathways in KD and explore the diagnostic, prognostic, and therapeutic potential of this new technique in KD. Using combinations of the search phrases 'KD, scRNA-seq, CAA, childhood vasculitis' a literature search was carried out on Scopus, Google Scholar, PubMed until the beginning of 2024.Expert opinion: scRNA-seq presents a transformative tool for dissecting KD at the cellular level. By revealing rare cell populations, gene expression alterations, and disease-specific pathways, scRNA-seq aids in understanding the intricacies of KD pathogenesis. This review will provide new insights into pathogenesis of KD and the field of applications of single-cell RNA sequencing in personalized therapeutics for KD in the future.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resveratrol: immunological activity and possible application in children and adolescents with allergic rhinitis. 白藜芦醇：免疫活性及在儿童和青少年过敏性鼻炎患者中的可能应用。

IF 3.9 3区医学

Expert Review of Clinical Immunology Pub Date : 2024-09-02 DOI: 10.1080/1744666X.2024.2399705

Matteo Naso, Chiara Trincianti, Lorenzo Drago, Maria Daglia, Giulia Brindisi, Francesco Paolo Brunese, Giulio Dinardo, Alessandra Gori, Cristiana Indolfi, Enrico Tondina, Attilio Varricchio, Anna Maria Zicari, Giorgio Ciprandi

引用次数: 0

Updating on pregnancy in rheumatoid arthritis. 类风湿关节炎患者怀孕的最新情况。

IF 3.9 3区医学

Expert Review of Clinical Immunology Pub Date : 2024-09-01 Epub Date: 2024-05-20 DOI: 10.1080/1744666X.2024.2356164

Carlotta Schenone, Greta Pacini, Emanuele Gotelli, Elvis Hysa, Rosanna Campitiello, Silvia Sammorì, Sabrina Paolino, Alberto Sulli, Maurizio Cutolo

{"title":"Updating on pregnancy in rheumatoid arthritis.","authors":"Carlotta Schenone, Greta Pacini, Emanuele Gotelli, Elvis Hysa, Rosanna Campitiello, Silvia Sammorì, Sabrina Paolino, Alberto Sulli, Maurizio Cutolo","doi":"10.1080/1744666X.2024.2356164","DOIUrl":"10.1080/1744666X.2024.2356164","url":null,"abstract":"Introduction: Rheumatoid arthritis (RA), the most prevalent autoimmune disease in reproductive years, exhibits a higher incidence in females, suggesting involvement of estrogens, genetics and environmental factors in disease onset. Literature shows smaller families in RA patients, driving increased interest in Assisted Reproductive Techniques.Areas covered: This review elucidates how immunotolerance mechanisms contribute to favorable pregnancy outcomes in RA, emphasizing the need for a careful pregnancy planning to mitigate fetal complications and postnatal flares, which surpass those in the general population. A thorough medication evaluation, orchestrated by a multidisciplinary team, is imperative during pregnancy, weighing potential teratogenic effects against safer alternatives to balance medication safety with disease control. A systematic literature search on PubMed and MEDLINE, using specific terms, covered relevant academic journals up to the latest date.Expert opinion: This narrative review comprehensively addresses pregnancy-related considerations in RA patients, prioritizing meticulous disease management with pregnancy and breastfeeding-compatible drugs in line with the latest recommendations and registry data. The focus remains on evaluating glucocorticoids, conventional, and biological disease-modifying drugs for compatibility during pregnancy and breastfeeding. Additionally, the evolving landscape of targeted synthetic drugs during pregnancy is explored, providing insights into the latest developments in rheumatological care.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0