Expert Review of Clinical Immunology最新文献_第3页

Potential future biologic therapies for the treatment of vitiligo: focus on phase 2 and 3. 未来治疗白癜风的潜在靶向疗法：重点是2期和3期。

IF 3.9 3区医学

Expert Review of Clinical Immunology Pub Date : 2025-06-01 Epub Date: 2025-05-27 DOI: 10.1080/1744666X.2025.2512452

Vincenzo Picone, Luigi Coronella, Massimiliano Scalvenzi, Cataldo Patruno, Ludovica Lizzi, Marianna Cimmino, Maddalena Napolitano

{"title":"Potential future biologic therapies for the treatment of vitiligo: focus on phase 2 and 3.","authors":"Vincenzo Picone, Luigi Coronella, Massimiliano Scalvenzi, Cataldo Patruno, Ludovica Lizzi, Marianna Cimmino, Maddalena Napolitano","doi":"10.1080/1744666X.2025.2512452","DOIUrl":"10.1080/1744666X.2025.2512452","url":null,"abstract":"Introduction: Vitiligo is a chronic autoimmune skin disorder characterized by the loss of melanocytes, leading to depigmented patches on the skin and mucous membranes. Its increasing prevalence and impact on patients' quality of life highlight the need for updated therapeutic strategies.Areas covered: This review discusses recent advances in the understanding of vitiligo pathogenesis, focusing on genetic predisposition, environmental triggers, and immune dysregulation-particularly the role of autoreactive CD8+ T cells and inflammatory cytokines such as IFN-γ. The literature search included recent clinical trials and emerging therapies. Novel approaches, including JAK inhibitors (e.g. povorcitinib, upadacitinib) and monoclonal antibodies (e.g. anifrolumab), are evaluated for their efficacy and safety based on phase II and III clinical trial data.Expert opinion: Targeted therapies that address immune mechanisms and oxidative stress represent promising advances in vitiligo management and may substantially improve patient outcomes in the near future.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"711-721"},"PeriodicalIF":3.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vascular endothelial dysfunction in pediatric rheumatic diseases: a systematic review and meta-analysis. 儿童风湿病的血管内皮功能障碍：系统回顾和荟萃分析。

IF 3.9 3区医学

Expert Review of Clinical Immunology Pub Date : 2025-06-01 Epub Date: 2025-05-31 DOI: 10.1080/1744666X.2025.2510490

Marieta P Theodorakopoulou, Vasiliki Sgouropoulou, Fotini Iatridi, Artemios G Karagiannidis, Antonios Karpetas, Erasmia Sampani, Panagiota Anyfanti, Theodoros Dimitroulas, Pantelis Sarafidis

{"title":"Vascular endothelial dysfunction in pediatric rheumatic diseases: a systematic review and meta-analysis.","authors":"Marieta P Theodorakopoulou, Vasiliki Sgouropoulou, Fotini Iatridi, Artemios G Karagiannidis, Antonios Karpetas, Erasmia Sampani, Panagiota Anyfanti, Theodoros Dimitroulas, Pantelis Sarafidis","doi":"10.1080/1744666X.2025.2510490","DOIUrl":"10.1080/1744666X.2025.2510490","url":null,"abstract":"Objectives: Endothelial dysfunction is associated with increased cardiovascular risk in individuals with autoimmune diseases. This systematic review and meta-analysis included studies assessing endothelial function with functional methods in children with rheumatic diseases versus controls.Methods: Literature search involved PubMed and Scopus databases (from inception to February 2024) and manual reference screening. Studies assessing endothelial function by all available functional methods were eligible. Study quality was evaluated via Newcastle-Ottawa scale.Results: Twenty-four studies (880 children with rheumatic diseases, 784 controls) were included in meta-analysis. Pooled analysis showed significantly impaired endothelial function in patients versus controls (SMD: -0.74, 95%CI -1.10 to -0.39) but with high heterogeneity (I2 = 91%, p < 0.001); sensitivity analysis including only high-quality studies confirmed this finding (SMD: -0.83, 95%CI -1.20 to -0.46). In subgroup analyses according to type of rheumatic disease, significantly impaired endothelial function was showed for patients with juvenile idiopathic arthritis (SMD: -1.05, 95%CI -1.84 to -0.25), vasculitis (SMD: -0.74, 95%CI -1.11 to -0.37) and juvenile systemic sclerosis (SMD -2.48, 95%CI -4.34 to -0.61).Conclusions: Children with rheumatic diseases show impaired endothelial function. Future studies are needed to elucidate whether endothelial dysfunction is involved in high cardiovascular risk of these patients.Prospero registration number: CRD42023413799.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"775-785"},"PeriodicalIF":3.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Host immune response to respiratory syncytial virus infection and its contribution to protection and susceptibility in adults: a systematic literature review. 成人呼吸道合胞病毒感染的宿主免疫反应及其对保护和易感性的贡献：系统的文献综述。

IF 3.9 3区医学

Expert Review of Clinical Immunology Pub Date : 2025-06-01 Epub Date: 2025-05-02 DOI: 10.1080/1744666X.2025.2494658

Agnes Chaumont, Alison Martin, Johan Flamaing, Dexter J Wiseman, Corinne Vandermeulen, Erik Jongert, Timothy Mark Doherty, Philippe Buchy, Steven M Varga, Lucile Warter

{"title":"Host immune response to respiratory syncytial virus infection and its contribution to protection and susceptibility in adults: a systematic literature review.","authors":"Agnes Chaumont, Alison Martin, Johan Flamaing, Dexter J Wiseman, Corinne Vandermeulen, Erik Jongert, Timothy Mark Doherty, Philippe Buchy, Steven M Varga, Lucile Warter","doi":"10.1080/1744666X.2025.2494658","DOIUrl":"10.1080/1744666X.2025.2494658","url":null,"abstract":"Introduction: Respiratory syncytial virus (RSV) is an important pathogen in infants, children, older adults, and those with comorbidities. Mechanisms involving viral proteins appear to underlie the ability of RSV to evade and modulate host immunity. We aimed to understand virus- and host-dependent factors regulating the development and severity of RSV infection, as related to the prevention and treatment of RSV-associated disease in adults, through a systematic literature review (SLR).Methods: An SLR was conducted to identify immune mechanisms involved in the protective response to RSV infection in adults, and responses that may contribute to the development of severe disease. Concurrent searches (MEDLINE/Embase) using embase.com identified relevant papers published between 1990 and 19 April 2023.Results: Of 1813 records identified, 113 were selected for review. Inclusion criteria were based on relevant patient populations, outcomes, and study methodologies. RSV is common, recurrent, and associated with high morbidity and mortality in older adults and people with underlying chronic diseases. Immune responses differ between younger and older adults. The approval of effective vaccines may protect older individuals from symptomatic RSV infection.Conclusions: We established the complexities of RSV immune response, but further research is required to fully understand anti-RSV immunology.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"745-760"},"PeriodicalIF":3.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Full consideration of the pollen exposure effect in clinical trial design for pollen-induced allergic rhinitis. 花粉性变应性鼻炎临床试验设计应充分考虑花粉暴露效应。

IF 3.9 3区医学

Expert Review of Clinical Immunology Pub Date : 2025-06-01 Epub Date: 2025-05-14 DOI: 10.1080/1744666X.2025.2504987

Dandan Fang, Xu Zhang, Jingyun Li, Luo Zhang, Yuan Zhang

{"title":"Full consideration of the pollen exposure effect in clinical trial design for pollen-induced allergic rhinitis.","authors":"Dandan Fang, Xu Zhang, Jingyun Li, Luo Zhang, Yuan Zhang","doi":"10.1080/1744666X.2025.2504987","DOIUrl":"10.1080/1744666X.2025.2504987","url":null,"abstract":"Introduction: Allergic rhinitis (AR) is global health concern with an increasing prevalence. Among them, pollen-induced AR (PIAR) exhibits more severe and intense symptoms, decreased quality of life, prominent local inflammation, and is thus more challenging to control. Due to the difficulties in disease control, in recent years, an increasing number of treatment methods, including pharmacotherapy, allergen-specific immunotherapy, and newly developed biologics, have focused on PIAR. It has been shown that the pollen exposure has a significant impact on the symptoms of PIAR and the efficacy of intervention. From this perspective, clinical trials for PIAR need to take full account of pollen exposure, especially when assessing efficacy.Areas covered: This review summarized the effect of pollen exposure on PIAR, including immune responses, symptoms and clinic visits. Current definitions for the pollen season (PS) and the peak pollen season (PPS) are discussed. Based on the previous PIAR-related clinical studies and the available recommendations for clinical trial design, a detailed account of trial protocols which fully considered pollen exposure is provided.Expert opinion: Pollen exposure has a significant impact on PIAR. With fully considering the pollen exposure in the clinical trial design for PIAR, future protocols for PIAR-related studies may be more objective and better harmonized and, therefore, comparable.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"731-743"},"PeriodicalIF":3.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dysautonomia in systemic lupus erythematosus: when to suspect and how to investigate. 系统性红斑狼疮的自主神经异常：何时怀疑及如何调查。

IF 3.9 3区医学

Expert Review of Clinical Immunology Pub Date : 2025-06-01 Epub Date: 2025-06-09 DOI: 10.1080/1744666X.2025.2511265

Caio Francisco C Frazatto, Alberto Rolim Muro Martinez, Simone Appenzeller

{"title":"Dysautonomia in systemic lupus erythematosus: when to suspect and how to investigate.","authors":"Caio Francisco C Frazatto, Alberto Rolim Muro Martinez, Simone Appenzeller","doi":"10.1080/1744666X.2025.2511265","DOIUrl":"10.1080/1744666X.2025.2511265","url":null,"abstract":"Introduction: Among the neuropsychiatric manifestations of Systemic lupus erythematosus (SLE), there are manifestations related to the peripheral nervous system (PNS). The autonomic nervous system, a subdivision of the PNS, is poorly studied in patients with SLE, and most often not recognized in clinical practice. However, it's possible that autonomic impairment is more common than we thought and many manifestations without a clear pathophysiology may be explained by autonomic impairment.Areas covered: This review is based on selected articles from the PUBMED database that evaluated autonomic dysfunction in SLE. Also explored some common symptoms in SLE without a clearly explanation, that can be due to autonomic impairment. Finally, we propose a clinical approach to autonomic evaluation in SLE.Expert opinion: A wide range of clinical manifestations in SLE can be attributed to autonomic dysfunction, therefore it is important to search for this diagnosis to correctly treat patients and promote a better quality of life. The long-term impact of autonomic impairment is unknown, and yet there is no biomarker that can help in the diagnosis.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"701-710"},"PeriodicalIF":3.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meta-analysis for alterations of IFN-γ, TNF-α and granzyme B levels in vitiligo patients. 白癜风患者IFN-γ、TNF-α和颗粒酶B水平变化的meta分析。

IF 3.9 3区医学

Expert Review of Clinical Immunology Pub Date : 2025-06-01 Epub Date: 2025-05-26 DOI: 10.1080/1744666X.2025.2510491

Prashant S Giri, Shivani Patel, Foram Thakor, Mitesh Dwivedi

{"title":"Meta-analysis for alterations of IFN-γ, TNF-α and granzyme B levels in vitiligo patients.","authors":"Prashant S Giri, Shivani Patel, Foram Thakor, Mitesh Dwivedi","doi":"10.1080/1744666X.2025.2510491","DOIUrl":"10.1080/1744666X.2025.2510491","url":null,"abstract":"Background: Vitiligo is a chronic autoimmune skin depigmenting condition. IFN-γ, TNF-α and granzyme B play key roles in vitiligo pathogenesis, some findings suggest their roles may be contradictory.Objective: We aimed to assess IFN-γ, TNF-α and granzyme B levels in blood and skin of vitiligo patients using a meta-analysis approach. Additionally, we evaluated their association with disease activity.Methods: A Meta-analysis was conducted using Review Manager 5.4 software. A total of 55 studies including 3,023 vitiligo patients and 2,534 controls were included in the study.Results: Pooled results from our meta-analysis indicated significantly elevated IFN-γ protein and transcript levels in blood and skin of vitiligo patients (p < 0.05). TNF-α protein levels were also significantly increased in blood and skin of vitiligo patients (p < 0.05). IFN-γ and TNF-α levels were significantly higher in the lesional skin as compared to non-lesional skin (p < 0.05). Furthermore, elevated levels of IFN-γ and TNF-α were observed in patients with active vitiligo (p < 0.05). Additionally, our study suggested a significant increase in granzyme B levels in vitiligo patients (p < 0.05).Conclusion: Overall, the meta-analysis suggests that IFN-γ, TNF-α and granzyme B play a crucial role in vitiligo pathogenesis and progression and may serve as potential therapeutic targets for managing the disease. The PROSPERO registration no. for meta-analysis is CRD42024620274.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"761-774"},"PeriodicalIF":3.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thyroid eye disease in the biologic era: a 40-year paradigm shift in nonsurgical therapeutic strategies. 生物时代的甲状腺眼病：40年来非手术治疗策略的范式转变

IF 3.9 3区医学

Expert Review of Clinical Immunology Pub Date : 2025-06-01 Epub Date: 2025-05-25 DOI: 10.1080/1744666X.2025.2509582

Erqian Wang, Zuyi Yang, Zhixuan Xie, Dianzhe Tian, Haiyan Xu, Hui Li, Youxin Chen

{"title":"Thyroid eye disease in the biologic era: a 40-year paradigm shift in nonsurgical therapeutic strategies.","authors":"Erqian Wang, Zuyi Yang, Zhixuan Xie, Dianzhe Tian, Haiyan Xu, Hui Li, Youxin Chen","doi":"10.1080/1744666X.2025.2509582","DOIUrl":"10.1080/1744666X.2025.2509582","url":null,"abstract":"Background: Over the last four decades, there has been a progressive increase in the number of publications and citations on research related to thyroid-associated ophthalmopathy (TAO) nonsurgical treatment across many countries/regions, institutions, and authors, with a special focus on biological immunotherapy.Research design and methods: Examing 1600 publications collected from the Web of Science Core Collection database on TAO research from 1983 to 2023, our bibliometric analysis evaluated various bibliometric indicators, among which some important subtopics were identified and further discussed and reviewed.Results: The study showed that novel insights into the pathogenesis of TAO and new immunological targets for nonsurgical treatments were the major research focus over the past 40 years. Especially, targeted biological immunotherapies were on the rise, promoting treatments efficacy and patients' quality of life.Conclusions: Our study provided a thorough overview and visual presentation of the evolutionary landscape and emerging frontiers for nonsurgical treatment of TAO surrounding its immunological mechanism and therapeutic strategy. It also shed light on its global collaboration patterns, current trends and research hotspots, hopefully to facilitate collaborative initiatives and guiding future research.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"787-802"},"PeriodicalIF":3.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation of serum Helios, CD226, TIGIT, and Foxp3 with tear film osmotic pressure and dry eye disease in patients with rheumatoid arthritis. 类风湿性关节炎患者血清Helios、CD226、tigit和Foxp3与泪膜渗透压和干眼症的相关性

IF 3.9 3区医学

Expert Review of Clinical Immunology Pub Date : 2025-06-01 Epub Date: 2025-06-16 DOI: 10.1080/1744666X.2025.2512451

Lijing Huang, Peilin Cheng, Zheli Niu, Liping Zang, Zicong Chen, Chunchun Yang, Wenhua Ma, Wenjia Nie

{"title":"Correlation of serum Helios, CD226, TIGIT, and Foxp3 with tear film osmotic pressure and dry eye disease in patients with rheumatoid arthritis.","authors":"Lijing Huang, Peilin Cheng, Zheli Niu, Liping Zang, Zicong Chen, Chunchun Yang, Wenhua Ma, Wenjia Nie","doi":"10.1080/1744666X.2025.2512451","DOIUrl":"10.1080/1744666X.2025.2512451","url":null,"abstract":"Objective: This study investigated the correlation between serum Helios, CD226, TIGIT, and Foxp3 levels and tear film osmotic pressure in individuals with rheumatoid arthritis (RA) and dry eye disease.Methods: This case-control study enrolled 100 RA patients with dry eye and 100 healthy controls from May 2021 to June 2022. mRNA expression of target genes was quantified using quantitative real-time PCR (qRT-PCR). Tear film osmolality was measured with a commercial osmometer. Statistical analyses included Pearson correlation and multivariate logistic regression.Results: Compared with controls, RA patients exhibited significantly higher mRNA levels of Helios, CD226, TIGIT, and Foxp3 (p < 0.05), along with elevated mean tear osmolarity (312.5 ± 12.3 vs. 295.4 ± 10.8 milliosmoles per liter (mOsm/L), p < 0.05). Notably, 68% of RA patients exceeded the 308 mOsm/L diagnostic threshold versus 22% controls (p < 0.05). Helios (r = 0.62) and Foxp3 (r = 0.58) correlated positively with osmotic pressure, while TIGIT showed a negative correlation (r = -0.49, p < 0.05). Logistic regression revealed that elevated levels of Helios (OR = 2.1, 95% CI: 1.4-3.2), CD226 (OR = 1.8, 95% CI: 1.2-2.7), and Foxp3 (OR = 1.9, 95% CI: 1.3-2.8) were associated with increased dry eye risk (p < 0.05).Conclusion: These immune markers demonstrate significant associations with tear film instability in RA, serving as potential biomarkers for ocular comorbidity monitoring.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"815-823"},"PeriodicalIF":3.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AQP9 weakens the cytotoxicity of CD8⁺ T cells in colon adenocarcinoma by boosting M2 polarization of macrophages under hypoxia conditions. 在缺氧条件下，AQP9通过促进巨噬细胞M2极化，减弱CD8+ T细胞在结肠腺癌中的细胞毒性。

IF 3.9 3区医学

Expert Review of Clinical Immunology Pub Date : 2025-06-01 Epub Date: 2025-05-08 DOI: 10.1080/1744666X.2025.2501718

Jinping Chen, Zongda Cai, Shurong Huang, Yangqiang Wang, Shiyang Zhan, Wei Zheng, Pan Chi

{"title":"AQP9 weakens the cytotoxicity of CD8+ T cells in colon adenocarcinoma by boosting M2 polarization of macrophages under hypoxia conditions.","authors":"Jinping Chen, Zongda Cai, Shurong Huang, Yangqiang Wang, Shiyang Zhan, Wei Zheng, Pan Chi","doi":"10.1080/1744666X.2025.2501718","DOIUrl":"10.1080/1744666X.2025.2501718","url":null,"abstract":"Background: Colon adenocarcinoma (COAD) is a leading cause of cancer mortality, with Aquaporin 9 (AQP9) implicated in its progression. M2 macrophages in the tumor microenvironment (TME) promote cancer metastasis, but the role of AQP9 on M2 macrophages remains unelucidated.Research design and methods: Using COAD cell lines, AQP9 expression was analyzed via RT-qPCR and Western blot (WB). Hypoxic conditions were simulated to assess HIF-1α and AQP9 interactions through ChIP and dual-luciferase assays. AQP9 knockdown effects on proliferation/migration were tested via colony formation and wound healing. M2 macrophage polarization and CD8+ T cell cytotoxicity were evaluated using flow cytometry, ELISA, and IHC in co-culture systems.Results: AQP9 was upregulated in COAD and correlated with poor prognosis. After AQP9 in COAD cells was knocked down, the abilities of tumor cells to migrate and proliferate were dampened. Hypoxia upregulated HIF-1α, which transcriptionally activated AQP9. Knocking down AQP9 repressed the M2 polarization of macrophages, thereby reinforcing the cytotoxicity of CD8+ T cells. No adverse events were reported in vitro.Conclusion: AQP9 promotes COAD progression by driving HIF-1α-mediated M2 polarization, impairing CD8+ T cell function. Key limitations include the lack of in vivo validation and clinical cohort analysis.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"803-814"},"PeriodicalIF":3.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucocorticoid in systemic lupus erythematosus: the art beyond science. 系统性红斑狼疮的糖皮质激素：超越科学的艺术。

IF 3.9 3区医学

Expert Review of Clinical Immunology Pub Date : 2025-05-01 Epub Date: 2025-04-18 DOI: 10.1080/1744666X.2025.2494654

Tsz Ching Mok, Chi Chiu Mok

{"title":"Glucocorticoid in systemic lupus erythematosus: the art beyond science.","authors":"Tsz Ching Mok, Chi Chiu Mok","doi":"10.1080/1744666X.2025.2494654","DOIUrl":"10.1080/1744666X.2025.2494654","url":null,"abstract":"Introduction: Glucocorticoid (GC) remains the main stay of treatment for systemic lupus erythematosus (SLE) but is associated with a myriad of untoward effects. On the other hand, withdrawal of maintenance immunosuppression, including low-dose GCs, carries a risk of SLE flare.Areas covered: The molecular mechanisms of GCs and their implications for dosing strategies in clinical practice are discussed. Evidence regarding withdrawal of maintenance immunosuppression in SLE is reviewed.Expert opinions: The initial GC regimens for different manifestations of SLE are heterogeneous, with no major randomized controlled trials (RCTs) on their efficacy and toxicities available. RCTs on withdrawal of immunosuppressive drugs in quiescent SLE are inconsistent but appear to show an increase in disease flares, with risk factors being younger age, renal disease, cessation of hydroxychloroquine, shorter duration of remission, serological activity, and an abrupt tapering regime. The lowest effective doses of GC and immunosuppressive drugs should be adopted, and the decision to withdraw immunosuppression should be individualized. Newer strategies for GC sparing, including combination therapy of immunosuppressive and biological/targeted agents, and the use of methylprednisolone pulses for initial therapy of less serious manifestations of SLE, could ameliorate the toxicities of immunosuppression and help advance to the ultimate target of drug-free remission.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"543-553"},"PeriodicalIF":3.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0