生物时代的甲状腺眼病:40年来非手术治疗策略的范式转变

IF 3.9 3区 医学 Q2 IMMUNOLOGY
Erqian Wang, Zuyi Yang, Zhixuan Xie, Dianzhe Tian, Haiyan Xu, Hui Li, Youxin Chen
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引用次数: 0

摘要

背景:在过去的四十年中,在许多国家/地区、机构和作者中,与甲状腺相关性眼病(TAO)非手术治疗相关的研究出版物和引用数量逐渐增加,特别关注生物免疫治疗。研究设计与方法:以1983 ~ 2023年Web of Science Core Collection数据库中收录的1600篇TAO研究论文为研究对象,进行文献计量学分析,评估各项文献计量学指标,找出其中一些重要的子主题,并对其进行进一步讨论和评述。结果:研究表明,对TAO发病机制的新认识和非手术治疗的新免疫靶点是过去40年来的主要研究热点。特别是靶向生物免疫疗法的兴起,提高了治疗效果和患者的生活质量。结论:我们的研究为TAO非手术治疗的发展前景和新兴领域提供了全面的概述和视觉展示,包括其免疫机制和治疗策略。它还揭示了其全球合作模式,当前趋势和研究热点,希望促进合作倡议和指导未来的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Thyroid eye disease in the biologic era: a 40-year paradigm shift in nonsurgical therapeutic strategies.

Background: Over the last four decades, there has been a progressive increase in the number of publications and citations on research related to thyroid-associated ophthalmopathy (TAO) nonsurgical treatment across many countries/regions, institutions, and authors, with a special focus on biological immunotherapy.

Research design and methods: Examing 1600 publications collected from the Web of Science Core Collection database on TAO research from 1983 to 2023, our bibliometric analysis evaluated various bibliometric indicators, among which some important subtopics were identified and further discussed and reviewed.

Results: The study showed that novel insights into the pathogenesis of TAO and new immunological targets for nonsurgical treatments were the major research focus over the past 40 years. Especially, targeted biological immunotherapies were on the rise, promoting treatments efficacy and patients' quality of life.

Conclusions: Our study provided a thorough overview and visual presentation of the evolutionary landscape and emerging frontiers for nonsurgical treatment of TAO surrounding its immunological mechanism and therapeutic strategy. It also shed light on its global collaboration patterns, current trends and research hotspots, hopefully to facilitate collaborative initiatives and guiding future research.

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来源期刊
CiteScore
7.60
自引率
2.30%
发文量
221
审稿时长
6-12 weeks
期刊介绍: Expert Review of Clinical Immunology (ISSN 1744-666X) provides expert analysis and commentary regarding the performance of new therapeutic and diagnostic modalities in clinical immunology. Members of the International Editorial Advisory Panel of Expert Review of Clinical Immunology are the forefront of their area of expertise. This panel works with our dedicated editorial team to identify the most important and topical review themes and the corresponding expert(s) most appropriate to provide commentary and analysis. All articles are subject to rigorous peer-review, and the finished reviews provide an essential contribution to decision-making in clinical immunology. Articles focus on the following key areas: • Therapeutic overviews of specific immunologic disorders highlighting optimal therapy and prospects for new medicines • Performance and benefits of newly approved therapeutic agents • New diagnostic approaches • Screening and patient stratification • Pharmacoeconomic studies • New therapeutic indications for existing therapies • Adverse effects, occurrence and reduction • Prospects for medicines in late-stage trials approaching regulatory approval • Novel treatment strategies • Epidemiological studies • Commentary and comparison of treatment guidelines Topics include infection and immunity, inflammation, host defense mechanisms, congenital and acquired immunodeficiencies, anaphylaxis and allergy, systemic immune diseases, organ-specific inflammatory diseases, transplantation immunology, endocrinology and diabetes, cancer immunology, neuroimmunology and hematological diseases.
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